LIN7A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in generating and maintaining the asymmetric distribution of channels and receptors at the cell membrane. The encoded protein also is required for the localization of some specific channels and can be part of a protein complex that couples synaptic vesicle exocytosis to cell adhesion in the brain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.99064602
2synaptic vesicle exocytosis (GO:0016079)5.43110537
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.33210550
4G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.26740512
5nucleobase catabolic process (GO:0046113)5.25105717
6vocalization behavior (GO:0071625)5.16541285
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.85151115
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.79092002
9gamma-aminobutyric acid signaling pathway (GO:0007214)4.78451958
10response to pheromone (GO:0019236)4.75192160
11glutamate receptor signaling pathway (GO:0007215)4.74791491
12protein localization to synapse (GO:0035418)4.72811380
13glutamate secretion (GO:0014047)4.71492682
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.66877179
15regulation of synaptic vesicle exocytosis (GO:2000300)4.61687061
16neuron cell-cell adhesion (GO:0007158)4.55051129
17cerebellar granule cell differentiation (GO:0021707)4.49421158
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.41694851
19neurotransmitter-gated ion channel clustering (GO:0072578)4.40165716
20positive regulation of synapse maturation (GO:0090129)4.39834966
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.33871201
22synaptic vesicle maturation (GO:0016188)4.26695815
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.23017609
24regulation of glutamate receptor signaling pathway (GO:1900449)4.20765568
25* neurotransmitter secretion (GO:0007269)4.20350973
26neuron-neuron synaptic transmission (GO:0007270)4.18952675
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.16779418
28positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.13292504
29cellular potassium ion homeostasis (GO:0030007)4.10034138
30neuronal action potential propagation (GO:0019227)4.07809874
31synaptic transmission, glutamatergic (GO:0035249)4.07396937
32synaptic vesicle endocytosis (GO:0048488)4.06075004
33cerebellar Purkinje cell differentiation (GO:0021702)4.04453417
34central nervous system projection neuron axonogenesis (GO:0021952)4.02341017
35cell migration in hindbrain (GO:0021535)4.01932209
36regulation of synaptic vesicle transport (GO:1902803)3.97940258
37locomotory exploration behavior (GO:0035641)3.95278638
38sodium ion export (GO:0071436)3.79960895
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.75400109
40response to histamine (GO:0034776)3.72840196
41neuronal ion channel clustering (GO:0045161)3.67875129
42negative regulation of cytosolic calcium ion concentration (GO:0051481)3.67591565
43regulation of dendritic spine morphogenesis (GO:0061001)3.67210138
44presynaptic membrane assembly (GO:0097105)3.64344166
45gamma-aminobutyric acid transport (GO:0015812)3.62393758
46behavioral response to cocaine (GO:0048148)3.61775518
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.61572436
48* neurotransmitter transport (GO:0006836)3.59941999
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.57072829
50detection of light stimulus involved in sensory perception (GO:0050962)3.55990135
51detection of light stimulus involved in visual perception (GO:0050908)3.55990135
52regulation of synapse maturation (GO:0090128)3.54391227
53detection of molecule of bacterial origin (GO:0032490)3.53587936
54leukocyte migration involved in inflammatory response (GO:0002523)3.53495685
55regulation of postsynaptic membrane potential (GO:0060078)3.53264926
56membrane depolarization during action potential (GO:0086010)3.52753830
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.51937283
58innervation (GO:0060384)3.45637648
59long-term synaptic potentiation (GO:0060291)3.44546296
60presynaptic membrane organization (GO:0097090)3.44509485
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.42482485
62cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.42053197
63regulation of neurotransmitter secretion (GO:0046928)3.37150797
64exploration behavior (GO:0035640)3.34870105
65postsynaptic membrane organization (GO:0001941)3.34417213
66membrane hyperpolarization (GO:0060081)3.33283825
67L-amino acid import (GO:0043092)3.32712919
68long-term memory (GO:0007616)3.31360254
69cell differentiation in hindbrain (GO:0021533)3.31193857
70synapse assembly (GO:0007416)3.30005956
71regulation of long-term neuronal synaptic plasticity (GO:0048169)3.29179277
72neuron recognition (GO:0008038)3.25054964
73prepulse inhibition (GO:0060134)3.23499002
74regulation of synapse structural plasticity (GO:0051823)3.21609409
75adult walking behavior (GO:0007628)3.20954703
76positive regulation of membrane potential (GO:0045838)3.20282151
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.20111636
78* regulation of neurotransmitter levels (GO:0001505)3.19561474
79regulation of neuronal synaptic plasticity (GO:0048168)3.17775411
80dendrite morphogenesis (GO:0048813)3.16498225
81retinal rod cell development (GO:0046548)3.16497874
82membrane depolarization (GO:0051899)3.16324251
83regulation of voltage-gated calcium channel activity (GO:1901385)3.14724004
84regulation of neurotransmitter transport (GO:0051588)3.13761916
85negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.11640403
86striatum development (GO:0021756)3.11240228
87central nervous system neuron axonogenesis (GO:0021955)3.10904128
88mating behavior (GO:0007617)3.07594473
89neutrophil mediated immunity (GO:0002446)3.06713146
90establishment of mitochondrion localization (GO:0051654)3.06575337
91positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.04769537
92cell communication by electrical coupling (GO:0010644)3.04236210
93long term synaptic depression (GO:0060292)3.01567566
94layer formation in cerebral cortex (GO:0021819)3.01225894
95synaptic transmission (GO:0007268)2.99427694
96negative regulation of dendrite development (GO:2000171)2.97535164
97transmission of nerve impulse (GO:0019226)2.97217276
98positive regulation of neurotransmitter secretion (GO:0001956)2.97112461
99positive regulation of synapse assembly (GO:0051965)2.97057318
100disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.96174679
101killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.96174679
102potassium ion homeostasis (GO:0055075)2.95509080
103relaxation of smooth muscle (GO:0044557)2.94233650
104regulation of vesicle fusion (GO:0031338)2.93643846
105cellular sodium ion homeostasis (GO:0006883)2.93618702
106myeloid leukocyte mediated immunity (GO:0002444)2.93584589
107behavioral fear response (GO:0001662)2.91786384
108behavioral defense response (GO:0002209)2.91786384
109auditory behavior (GO:0031223)2.91034407
110regulation of synaptic plasticity (GO:0048167)2.90713976
111regulation of dendritic spine development (GO:0060998)2.89970601
112positive regulation of neurotransmitter transport (GO:0051590)2.86670065
113fear response (GO:0042596)2.86654937
114dendritic spine morphogenesis (GO:0060997)2.84851206
115* synaptic vesicle transport (GO:0048489)2.84830881
116* establishment of synaptic vesicle localization (GO:0097480)2.84830881
117regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.84666519
118negative regulation of B cell mediated immunity (GO:0002713)2.84551380
119negative regulation of immunoglobulin mediated immune response (GO:0002890)2.84551380
120learning (GO:0007612)2.84371527
121nerve growth factor signaling pathway (GO:0038180)2.83779392
122olfactory bulb development (GO:0021772)2.81869365
123mechanosensory behavior (GO:0007638)2.81160359
124negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.80410756
125negative regulation of translation, ncRNA-mediated (GO:0040033)2.80410756
126regulation of translation, ncRNA-mediated (GO:0045974)2.80410756
127axonal fasciculation (GO:0007413)2.79150605
128positive regulation of dendritic spine morphogenesis (GO:0061003)2.78886548
129negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.77702793
130amino acid import (GO:0043090)2.75844415
131positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.72612865
132neurofilament cytoskeleton organization (GO:0060052)2.67965742
133regulation of dendrite morphogenesis (GO:0048814)2.67931174
134modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.65459495
135positive regulation by organism of defense response of other organism involved in symbiotic interact2.65459495
136modulation by symbiont of host immune response (GO:0052553)2.65459495
137positive regulation by symbiont of host defense response (GO:0052509)2.65459495
138modulation by symbiont of host defense response (GO:0052031)2.65459495
139modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.65459495
140positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.64434027
141response to auditory stimulus (GO:0010996)2.62788638
142neural tube formation (GO:0001841)2.61778072
143retinal ganglion cell axon guidance (GO:0031290)2.58904244
144synapse organization (GO:0050808)2.58564548
145proline transport (GO:0015824)2.58527943

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.69211844
2GBX2_23144817_ChIP-Seq_PC3_Human4.12366395
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90908926
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.89790962
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88537840
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77218401
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.76763699
8REST_21632747_ChIP-Seq_MESCs_Mouse2.64217669
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41983578
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40695211
11TAF15_26573619_Chip-Seq_HEK293_Human2.38216325
12* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37524789
13* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37524789
14* EZH2_27304074_Chip-Seq_ESCs_Mouse2.37194630
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34324795
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30477507
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29258845
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.23204894
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18774215
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.16702286
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15250462
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14875775
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13779084
24DROSHA_22980978_ChIP-Seq_HELA_Human2.12298343
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06467526
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.05988617
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02932389
28* RNF2_27304074_Chip-Seq_ESCs_Mouse2.01283593
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99878177
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.88514105
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.87717021
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87302513
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86925398
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86736169
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.85638974
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84247080
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82076499
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72631102
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72200806
40P300_19829295_ChIP-Seq_ESCs_Human1.72121663
41AR_21572438_ChIP-Seq_LNCaP_Human1.69149452
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.67529219
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62725052
44* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53165734
45VDR_22108803_ChIP-Seq_LS180_Human1.46288578
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.45424635
47AR_25329375_ChIP-Seq_VCAP_Human1.42207316
48ZNF274_21170338_ChIP-Seq_K562_Hela1.39770206
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.39698838
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38840891
51RNF2_27304074_Chip-Seq_NSC_Mouse1.37736591
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37026093
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33981130
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33367130
55FUS_26573619_Chip-Seq_HEK293_Human1.32465147
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.30246994
57P53_22127205_ChIP-Seq_FIBROBLAST_Human1.28633549
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28297560
59STAT3_23295773_ChIP-Seq_U87_Human1.26372438
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.26147095
61IGF1R_20145208_ChIP-Seq_DFB_Human1.25496153
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24163177
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23702189
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23224341
65* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22579042
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22494674
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21316989
68EWS_26573619_Chip-Seq_HEK293_Human1.20439235
69* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19405238
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19114017
71TCF4_23295773_ChIP-Seq_U87_Human1.18226292
72TP53_16413492_ChIP-PET_HCT116_Human1.17844210
73ER_23166858_ChIP-Seq_MCF-7_Human1.17302658
74* AR_19668381_ChIP-Seq_PC3_Human1.16868997
75LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16034090
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.15908465
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14308432
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13987995
79* RING1B_27294783_Chip-Seq_ESCs_Mouse1.13507652
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12079532
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11829233
82GATA1_26923725_Chip-Seq_HPCs_Mouse1.10132632
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10027024
84* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09720326
85STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09494873
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.09279139
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08553447
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08142345
89* ARNT_22903824_ChIP-Seq_MCF-7_Human1.08109596
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.08071436
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08020518
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08020518
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.07814559
94RUNX2_22187159_ChIP-Seq_PCA_Human1.04446412
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04170210
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03779953
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03675184
98ISL1_27105846_Chip-Seq_CPCs_Mouse1.02809405
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01851960
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00986404
101* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00792451
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00662930
103KDM2B_26808549_Chip-Seq_REH_Human0.99195221
104P53_22387025_ChIP-Seq_ESCs_Mouse0.99170151
105BCAT_22108803_ChIP-Seq_LS180_Human0.98810957
106CBP_20019798_ChIP-Seq_JUKART_Human0.98472408
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98472408
108YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98285280
109* AHR_22903824_ChIP-Seq_MCF-7_Human0.95930677
110* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95402688
111* PRDM14_20953172_ChIP-Seq_ESCs_Human0.95204676
112ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94671721
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94106485
114RING1B_27294783_Chip-Seq_NPCs_Mouse0.93985799
115E2F1_18555785_Chip-Seq_ESCs_Mouse0.93562943
116* FLI1_21867929_ChIP-Seq_TH2_Mouse0.93243185
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93007066
118JUN_21703547_ChIP-Seq_K562_Human0.92295473
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91508182
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.91250361
121SMAD3_21741376_ChIP-Seq_ESCs_Human0.91196364

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.74725137
2MP0004859_abnormal_synaptic_plasticity4.63298210
3* MP0003635_abnormal_synaptic_transmissio3.65890044
4MP0009046_muscle_twitch3.45002519
5MP0000569_abnormal_digit_pigmentation3.24160332
6MP0009745_abnormal_behavioral_response3.16852796
7MP0001968_abnormal_touch/_nociception3.14084161
8MP0004270_analgesia3.05351970
9MP0002064_seizures3.01496463
10MP0002063_abnormal_learning/memory/cond2.96648279
11MP0005551_abnormal_eye_electrophysiolog2.80691597
12MP0002272_abnormal_nervous_system2.70707045
13MP0002572_abnormal_emotion/affect_behav2.66934510
14MP0002736_abnormal_nociception_after2.56756898
15MP0002734_abnormal_mechanical_nocicepti2.54704567
16MP0001486_abnormal_startle_reflex2.53991191
17MP0001984_abnormal_olfaction2.50395781
18MP0003121_genomic_imprinting2.41164722
19MP0005423_abnormal_somatic_nervous2.39110846
20MP0002735_abnormal_chemical_nociception2.32720858
21MP0002067_abnormal_sensory_capabilities2.29051480
22MP0001501_abnormal_sleep_pattern2.16504942
23MP0001440_abnormal_grooming_behavior2.12846471
24MP0006276_abnormal_autonomic_nervous2.10946880
25MP0003890_abnormal_embryonic-extraembry2.02154669
26MP0002184_abnormal_innervation2.01245614
27MP0001502_abnormal_circadian_rhythm1.91013269
28MP0002822_catalepsy1.85001994
29MP0008569_lethality_at_weaning1.83776789
30MP0005386_behavior/neurological_phenoty1.73989164
31MP0004924_abnormal_behavior1.73989164
32MP0003724_increased_susceptibility_to1.72557199
33MP0002090_abnormal_vision1.72026567
34MP0006072_abnormal_retinal_apoptosis1.70760581
35MP0001970_abnormal_pain_threshold1.69044495
36MP0003879_abnormal_hair_cell1.67574693
37MP0005646_abnormal_pituitary_gland1.67451320
38MP0002733_abnormal_thermal_nociception1.67295375
39MP0001188_hyperpigmentation1.66316957
40MP0002557_abnormal_social/conspecific_i1.65888605
41MP0003329_amyloid_beta_deposits1.59257265
42MP0000778_abnormal_nervous_system1.57390283
43MP0004145_abnormal_muscle_electrophysio1.55104720
44MP0001529_abnormal_vocalization1.53387983
45MP0003690_abnormal_glial_cell1.46344168
46MP0004142_abnormal_muscle_tone1.45082529
47MP0004811_abnormal_neuron_physiology1.38447588
48MP0000955_abnormal_spinal_cord1.38229703
49MP0002882_abnormal_neuron_morphology1.37594077
50MP0009780_abnormal_chondrocyte_physiolo1.37349334
51MP0002928_abnormal_bile_duct1.35774908
52MP0005253_abnormal_eye_physiology1.35319520
53MP0002066_abnormal_motor_capabilities/c1.32330293
54MP0002909_abnormal_adrenal_gland1.30391320
55MP0002229_neurodegeneration1.27108098
56MP0005187_abnormal_penis_morphology1.23418085
57MP0004742_abnormal_vestibular_system1.21848256
58MP0003633_abnormal_nervous_system1.16996721
59MP0008872_abnormal_physiological_respon1.16290921
60MP0008877_abnormal_DNA_methylation1.15930873
61MP0003221_abnormal_cardiomyocyte_apopto1.13694724
62MP0008875_abnormal_xenobiotic_pharmacok1.11343507
63MP0004885_abnormal_endolymph1.11308837
64MP0003122_maternal_imprinting1.11034656
65MP0002837_dystrophic_cardiac_calcinosis1.10586111
66MP0004233_abnormal_muscle_weight1.08331615
67MP0001905_abnormal_dopamine_level1.05485094
68MP0005645_abnormal_hypothalamus_physiol1.04732752
69MP0002752_abnormal_somatic_nervous1.04485714
70MP0004215_abnormal_myocardial_fiber1.04212783
71MP0004858_abnormal_nervous_system1.03175975
72MP0003861_abnormal_nervous_system1.01368588
73MP0003631_nervous_system_phenotype1.00671330
74MP0002876_abnormal_thyroid_physiology1.00114487
75MP0003787_abnormal_imprinting0.98580252
76MP0002152_abnormal_brain_morphology0.98481380
77MP0005195_abnormal_posterior_eye0.95954635
78MP0005409_darkened_coat_color0.95831212
79MP0005535_abnormal_body_temperature0.95691771
80MP0005360_urolithiasis0.95429556
81MP0005365_abnormal_bile_salt0.95182849
82MP0008260_abnormal_autophagy0.94824888
83MP0004085_abnormal_heartbeat0.94587681
84MP0010386_abnormal_urinary_bladder0.94077028
85MP0002069_abnormal_eating/drinking_beha0.93983143
86MP0006292_abnormal_olfactory_placode0.92198520
87MP0004130_abnormal_muscle_cell0.91830536
88MP0001963_abnormal_hearing_physiology0.90559403
89MP0000631_abnormal_neuroendocrine_gland0.88434683
90MP0002751_abnormal_autonomic_nervous0.87601821
91MP0003172_abnormal_lysosome_physiology0.86639516
92MP0001986_abnormal_taste_sensitivity0.86307086
93MP0000751_myopathy0.85334420
94MP0005394_taste/olfaction_phenotype0.83561097
95MP0005499_abnormal_olfactory_system0.83561097
96MP0003938_abnormal_ear_development0.83262844
97MP0005084_abnormal_gallbladder_morpholo0.82690232
98MP0008874_decreased_physiological_sensi0.81433956
99MP0002653_abnormal_ependyma_morphology0.80922561
100MP0002139_abnormal_hepatobiliary_system0.80148476
101MP0005410_abnormal_fertilization0.79886932
102MP0004883_abnormal_blood_vessel0.76757683
103MP0002638_abnormal_pupillary_reflex0.75954139
104MP0003183_abnormal_peptide_metabolism0.74358859
105MP0002332_abnormal_exercise_endurance0.74000448
106MP0005085_abnormal_gallbladder_physiolo0.73793139
107MP0003632_abnormal_nervous_system0.73582499
108MP0000604_amyloidosis0.73268295
109MP0000920_abnormal_myelination0.70822732
110MP0002009_preneoplasia0.70784911
111MP0003123_paternal_imprinting0.69933923
112MP0000534_abnormal_ureter_morphology0.69451392
113MP0003252_abnormal_bile_duct0.69267229
114MP0003011_delayed_dark_adaptation0.69044550
115MP0003942_abnormal_urinary_system0.68973939
116MP0010329_abnormal_lipoprotein_level0.68837967
117MP0004036_abnormal_muscle_relaxation0.68670967
118MP0006035_abnormal_mitochondrial_morpho0.68585843
119MP0001177_atelectasis0.68427382
120MP0003303_peritoneal_inflammation0.68262442
121* MP0002081_perinatal_lethality0.64925824
122MP0004043_abnormal_pH_regulation0.64694332
123MP0003137_abnormal_impulse_conducting0.64575440
124MP0004133_heterotaxia0.64108790
125MP0003119_abnormal_digestive_system0.63685746
126MP0005248_abnormal_Harderian_gland0.62828307
127MP0005595_abnormal_vascular_smooth0.62582973
128MP0003634_abnormal_glial_cell0.61977104
129MP0000026_abnormal_inner_ear0.60877317
130MP0000013_abnormal_adipose_tissue0.60813857
131MP0005174_abnormal_tail_pigmentation0.60648389
132MP0004484_altered_response_of0.59528382
133MP0001324_abnormal_eye_pigmentation0.58060541
134* MP0001943_abnormal_respiration0.57221976

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.74211482
2Congenital stationary night blindness (HP:0007642)6.14934441
3Epileptic encephalopathy (HP:0200134)5.76663138
4Febrile seizures (HP:0002373)5.47724831
5Atonic seizures (HP:0010819)5.07822992
6Focal seizures (HP:0007359)5.07085804
7Progressive cerebellar ataxia (HP:0002073)5.04782441
8Absence seizures (HP:0002121)4.86217159
9Visual hallucinations (HP:0002367)4.72474486
10Myokymia (HP:0002411)4.66086031
11Hyperventilation (HP:0002883)4.55117717
12Dialeptic seizures (HP:0011146)4.30277385
13Action tremor (HP:0002345)3.75512574
14Gaze-evoked nystagmus (HP:0000640)3.74046411
15Generalized tonic-clonic seizures (HP:0002069)3.71604086
16Papillary thyroid carcinoma (HP:0002895)3.49522888
17Broad-based gait (HP:0002136)3.47337606
18Dysdiadochokinesis (HP:0002075)3.44356436
19Abnormality of macular pigmentation (HP:0008002)3.41650167
20Central scotoma (HP:0000603)3.30285651
21Scanning speech (HP:0002168)3.27998098
22Truncal ataxia (HP:0002078)3.19513057
23Hemiparesis (HP:0001269)3.07503307
24Hepatoblastoma (HP:0002884)3.06611620
25Hypochromic microcytic anemia (HP:0004840)3.01374548
26Decreased central vision (HP:0007663)2.94625166
27Abnormality of the lower motor neuron (HP:0002366)2.93997355
28Dysmetric saccades (HP:0000641)2.92612544
29Genetic anticipation (HP:0003743)2.92049089
30Status epilepticus (HP:0002133)2.89309486
31Epileptiform EEG discharges (HP:0011182)2.88850101
32Drooling (HP:0002307)2.84047870
33Excessive salivation (HP:0003781)2.84047870
34Poor eye contact (HP:0000817)2.82101804
35Impaired smooth pursuit (HP:0007772)2.79080206
36Recurrent gram-negative bacterial infections (HP:0005420)2.78794273
37EEG with generalized epileptiform discharges (HP:0011198)2.74767140
38Amyotrophic lateral sclerosis (HP:0007354)2.72827983
39Dysmetria (HP:0001310)2.66393291
40Impaired social interactions (HP:0000735)2.60691906
41Abnormal social behavior (HP:0012433)2.60691906
42Abnormal eating behavior (HP:0100738)2.60657852
43Anxiety (HP:0000739)2.59417160
44Depression (HP:0000716)2.58633111
45Amblyopia (HP:0000646)2.58101605
46Cortical dysplasia (HP:0002539)2.53371732
47Abnormality of ocular smooth pursuit (HP:0000617)2.51854584
48Peritonitis (HP:0002586)2.50496197
49Aqueductal stenosis (HP:0002410)2.50417218
50Cholecystitis (HP:0001082)2.49778926
51Abnormal gallbladder physiology (HP:0012438)2.49778926
52Gait imbalance (HP:0002141)2.47772430
53Hypsarrhythmia (HP:0002521)2.41451302
54Polyphagia (HP:0002591)2.41414902
55Lower limb muscle weakness (HP:0007340)2.39768843
56Impaired vibration sensation in the lower limbs (HP:0002166)2.38570343
57Thyroid carcinoma (HP:0002890)2.36866954
58Absent speech (HP:0001344)2.34760124
59Severe visual impairment (HP:0001141)2.33940578
60Vitreoretinal degeneration (HP:0000655)2.33784802
61Urinary bladder sphincter dysfunction (HP:0002839)2.33614926
62Pheochromocytoma (HP:0002666)2.32058432
63Degeneration of the lateral corticospinal tracts (HP:0002314)2.31252689
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.31252689
65Mutism (HP:0002300)2.26422014
66Gastrointestinal infarctions (HP:0005244)2.25961470
67Abnormal rod and cone electroretinograms (HP:0008323)2.25495978
68Optic neuritis (HP:0100653)2.23029175
69Retrobulbar optic neuritis (HP:0100654)2.23029175
70Medial flaring of the eyebrow (HP:0010747)2.22094476
71Congenital primary aphakia (HP:0007707)2.22072364
72Choroideremia (HP:0001139)2.21966169
73Inability to walk (HP:0002540)2.21699895
74Progressive inability to walk (HP:0002505)2.19321738
75Scotoma (HP:0000575)2.19126099
76Protruding tongue (HP:0010808)2.18500918
77Supranuclear gaze palsy (HP:0000605)2.16134609
78Spastic gait (HP:0002064)2.11282433
79Lissencephaly (HP:0001339)2.11068582
80Lower limb asymmetry (HP:0100559)2.10618993
81Generalized hypotonia (HP:0001290)2.10245791
82Papilledema (HP:0001085)2.10029281
83Hemiplegia (HP:0002301)2.09848571
84Postural instability (HP:0002172)2.09640964
85Deep venous thrombosis (HP:0002625)2.06383513
86Intention tremor (HP:0002080)2.04750321
87Neuroendocrine neoplasm (HP:0100634)2.04601779
88Megalencephaly (HP:0001355)2.04499441
89Generalized myoclonic seizures (HP:0002123)2.03172821
90Fetal akinesia sequence (HP:0001989)2.02945895
91Diplopia (HP:0000651)2.02561677
92Abnormality of binocular vision (HP:0011514)2.02561677
93Nephrogenic diabetes insipidus (HP:0009806)2.01899765
94Shawl scrotum (HP:0000049)2.01559255
95Inappropriate behavior (HP:0000719)1.99893248
96Blue irides (HP:0000635)1.99775501
97Failure to thrive in infancy (HP:0001531)1.98624703
98Intellectual disability, moderate (HP:0002342)1.96693469
99Torticollis (HP:0000473)1.95729752
100Agitation (HP:0000713)1.95210577
101Impaired vibratory sensation (HP:0002495)1.94086027
102Abnormality of the corticospinal tract (HP:0002492)1.93983528
103Gait ataxia (HP:0002066)1.93907103
104Limb ataxia (HP:0002070)1.93608065
105Dynein arm defect of respiratory motile cilia (HP:0012255)1.93472302
106Absent/shortened dynein arms (HP:0200106)1.93472302
107Orchitis (HP:0100796)1.92331478
108Bony spicule pigmentary retinopathy (HP:0007737)1.91126562
109Ankle clonus (HP:0011448)1.90509249
110Bradykinesia (HP:0002067)1.89293754
111Heterochromia iridis (HP:0001100)1.89171215
112Specific learning disability (HP:0001328)1.88951360
113Limb dystonia (HP:0002451)1.88849873
114Genital tract atresia (HP:0001827)1.88652284
115Abnormality of saccadic eye movements (HP:0000570)1.87638408
116Vaginal atresia (HP:0000148)1.85263047
117Stereotypic behavior (HP:0000733)1.84969984
118Esotropia (HP:0000565)1.84634896
119Abnormality of the labia minora (HP:0012880)1.83110822
120Myelomeningocele (HP:0002475)1.82662894
121Fair hair (HP:0002286)1.81862733
122Focal dystonia (HP:0004373)1.80755277
123Intellectual disability, severe (HP:0010864)1.80237604
124Pachygyria (HP:0001302)1.79707362
125Abnormal hair whorl (HP:0010721)1.79196206
126Medulloblastoma (HP:0002885)1.78778969
127Narrow nasal bridge (HP:0000446)1.77237909
128Cerebral inclusion bodies (HP:0100314)1.77227674
129Hypochromic anemia (HP:0001931)1.76893121
130Clonus (HP:0002169)1.76478298
131Recurrent bacterial skin infections (HP:0005406)1.76415336
132Poor coordination (HP:0002370)1.75972726
133Insidious onset (HP:0003587)1.74774810
134Termporal pattern (HP:0011008)1.74774810
135Incomplete penetrance (HP:0003829)1.73771494
136Abnormality of salivation (HP:0100755)1.72219680
137Dyskinesia (HP:0100660)1.71618637
138Gingival bleeding (HP:0000225)1.71587021
139Morphological abnormality of the pyramidal tract (HP:0002062)1.71426202
140Recurrent abscess formation (HP:0002722)1.71382531
141Septo-optic dysplasia (HP:0100842)1.69829813
142Hypoplasia of the brainstem (HP:0002365)1.69692267
143Aplasia/Hypoplasia of the brainstem (HP:0007362)1.69692267
144Urinary urgency (HP:0000012)1.69550420
145Transitional cell carcinoma of the bladder (HP:0006740)1.69247450
146Exotropia (HP:0000577)1.68809727

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.37849065
2NTRK33.72373613
3MAP3K43.48007669
4EPHA43.24891654
5MAP2K73.00683444
6MAP3K92.87854504
7MARK12.69199212
8DAPK22.67854448
9MINK12.59364614
10MAP2K42.29142508
11PAK61.96230867
12MAP3K121.93580390
13PRPF4B1.89332664
14PNCK1.86622762
15NTRK21.79668813
16PLK21.77940713
17CAMKK21.71647622
18DYRK21.66696232
19YES11.51748076
20DAPK11.51443153
21CDK191.51134356
22GRK51.50883627
23KSR11.50201720
24RIPK41.49543407
25AKT31.44813583
26PRKCG1.42181290
27CAMKK11.40194915
28DYRK31.36721352
29FGFR21.34178806
30MAPK131.33793202
31SIK21.33561882
32DYRK1B1.33426987
33TNIK1.32649519
34CDK51.29438571
35EPHA31.27250463
36SGK4941.24502898
37SGK2231.24502898
38STK381.24379418
39SGK21.19535496
40CAMK2A1.18826098
41CCNB11.18664497
42SIK31.13864486
43KSR21.09351435
44DYRK1A1.07399655
45OXSR11.00194737
46PTK2B1.00148732
47NTRK10.99036576
48TRIM280.98445684
49PHKG20.97962015
50PHKG10.97962015
51ARAF0.93649335
52FES0.92440679
53CDK180.89851531
54WNK30.88306640
55CAMK2B0.88234511
56STK38L0.87489068
57INSRR0.87417283
58NME10.87256339
59CAMK10.86361790
60CDK150.84966826
61MAP3K130.84052773
62CDK140.83444326
63EPHB10.80366222
64IRAK20.79646316
65JAK20.79256796
66TNK20.77790104
67BLK0.77606295
68CAMK1G0.76877646
69BMPR20.76835829
70SGK30.76734442
71TYRO30.76246314
72CAMK2D0.75590605
73BRD40.74752333
74MAP3K50.74722550
75TAOK20.74144468
76CDK11A0.72554389
77UHMK10.72358239
78PDK30.68975524
79PDK40.68975524
80PINK10.68157239
81WNK10.66792207
82PRKCE0.66502256
83STK110.66480204
84SGK10.66403737
85CAMK1D0.65340102
86PIK3CA0.64352497
87CAMK2G0.63894704
88RPS6KB10.63226711
89CAMK40.62722939
90MAP3K20.62254103
91MARK20.61135255
92IRAK40.60550255
93PRKCZ0.59951829
94BCR0.57858564
95ADRBK20.57124533
96PKN20.56956740
97PRKG10.55365698
98CDK30.55061550
99CSNK1A1L0.55026945
100FER0.54894366
101FGFR30.54678556
102MAPK120.54085826
103PAK30.53604375
104RET0.51726505
105PRKACA0.50789688
106ROCK20.50148215
107TAOK10.49942765
108FRK0.49338639
109RIPK10.49325531
110RPS6KA30.49305408
111BRAF0.49226917
112GRK70.48266342
113FGR0.46926120
114ERBB30.46157098
115PRKCH0.45303981
116PDK10.44223209
117PRKCB0.43859603
118CSNK1G30.43469742
119ADRBK10.42815580
120MAP3K60.42734111
121CSNK1G20.42348340
122PKN10.42184927
123CSK0.42091370
124ALK0.41705548
125PRKCA0.41012685
126NEK10.40658449
127PRKACB0.39507107
128MAP2K30.39422431
129SYK0.37594567
130ERBB20.36423940
131FYN0.35988668
132RAF10.35952639
133MAP2K10.35702219
134MAPK100.32665497
135IRAK10.31347806
136STK240.30635578

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.74748880
2Synaptic vesicle cycle_Homo sapiens_hsa047213.51571303
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.02280349
4GABAergic synapse_Homo sapiens_hsa047273.00929333
5Morphine addiction_Homo sapiens_hsa050322.65128261
6Circadian entrainment_Homo sapiens_hsa047132.55872473
7Glutamatergic synapse_Homo sapiens_hsa047242.50741156
8Long-term potentiation_Homo sapiens_hsa047202.23969398
9Olfactory transduction_Homo sapiens_hsa047402.23445276
10Amphetamine addiction_Homo sapiens_hsa050312.11166784
11Salivary secretion_Homo sapiens_hsa049702.08463004
12Taste transduction_Homo sapiens_hsa047421.96805835
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88674110
14Dopaminergic synapse_Homo sapiens_hsa047281.87042714
15Insulin secretion_Homo sapiens_hsa049111.86133431
16Collecting duct acid secretion_Homo sapiens_hsa049661.84642651
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.80146199
18Renin secretion_Homo sapiens_hsa049241.78870912
19Phototransduction_Homo sapiens_hsa047441.76961764
20Long-term depression_Homo sapiens_hsa047301.76031242
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.73233460
22Steroid biosynthesis_Homo sapiens_hsa001001.69974613
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59063379
24Serotonergic synapse_Homo sapiens_hsa047261.59040234
25Cholinergic synapse_Homo sapiens_hsa047251.52460898
26Oxytocin signaling pathway_Homo sapiens_hsa049211.52021965
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47052313
28Calcium signaling pathway_Homo sapiens_hsa040201.46975852
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38265326
30Fatty acid biosynthesis_Homo sapiens_hsa000611.37013702
31Gastric acid secretion_Homo sapiens_hsa049711.36881092
32Cardiac muscle contraction_Homo sapiens_hsa042601.36021695
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29481921
34Cocaine addiction_Homo sapiens_hsa050301.23165624
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22238719
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18620173
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18198931
38Endometrial cancer_Homo sapiens_hsa052131.15725959
39Gap junction_Homo sapiens_hsa045401.12596933
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11769227
41Arginine biosynthesis_Homo sapiens_hsa002201.05575268
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05395731
43Circadian rhythm_Homo sapiens_hsa047101.03791537
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02663704
45cAMP signaling pathway_Homo sapiens_hsa040241.02303089
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.02250002
47GnRH signaling pathway_Homo sapiens_hsa049120.97728944
48Type II diabetes mellitus_Homo sapiens_hsa049300.97346856
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97123709
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96499497
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96441986
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95856288
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95119839
54Vibrio cholerae infection_Homo sapiens_hsa051100.89440123
55Butanoate metabolism_Homo sapiens_hsa006500.88821145
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88641237
57Non-small cell lung cancer_Homo sapiens_hsa052230.87353523
58Rap1 signaling pathway_Homo sapiens_hsa040150.87131224
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.87014734
60Bile secretion_Homo sapiens_hsa049760.86340208
61Colorectal cancer_Homo sapiens_hsa052100.86171233
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85828876
63Prolactin signaling pathway_Homo sapiens_hsa049170.85395366
64Nitrogen metabolism_Homo sapiens_hsa009100.84144046
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.79991002
66mTOR signaling pathway_Homo sapiens_hsa041500.79215440
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77644968
68Oxidative phosphorylation_Homo sapiens_hsa001900.77052375
69Alzheimers disease_Homo sapiens_hsa050100.74198763
70Chemokine signaling pathway_Homo sapiens_hsa040620.73898673
71Axon guidance_Homo sapiens_hsa043600.71771611
72Renal cell carcinoma_Homo sapiens_hsa052110.71220779
73Phagosome_Homo sapiens_hsa041450.70193298
74Osteoclast differentiation_Homo sapiens_hsa043800.69880675
75Estrogen signaling pathway_Homo sapiens_hsa049150.69465446
76FoxO signaling pathway_Homo sapiens_hsa040680.69416431
77Fatty acid metabolism_Homo sapiens_hsa012120.67185314
78Pancreatic secretion_Homo sapiens_hsa049720.65934171
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65160942
80Tuberculosis_Homo sapiens_hsa051520.64709667
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62237842
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.61912247
83Dilated cardiomyopathy_Homo sapiens_hsa054140.61307670
84Melanogenesis_Homo sapiens_hsa049160.59673887
85Thyroid hormone synthesis_Homo sapiens_hsa049180.59609744
86Staphylococcus aureus infection_Homo sapiens_hsa051500.58940239
87Glucagon signaling pathway_Homo sapiens_hsa049220.58792361
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58346568
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58333707
90Pyruvate metabolism_Homo sapiens_hsa006200.58293293
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57275118
92B cell receptor signaling pathway_Homo sapiens_hsa046620.57087260
93Wnt signaling pathway_Homo sapiens_hsa043100.56397652
94AMPK signaling pathway_Homo sapiens_hsa041520.56357119
95ErbB signaling pathway_Homo sapiens_hsa040120.56208389
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55994994
97Regulation of autophagy_Homo sapiens_hsa041400.51616898
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50820006
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50528699
100Glioma_Homo sapiens_hsa052140.50344209
101HIF-1 signaling pathway_Homo sapiens_hsa040660.48262647
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48179413
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47633597
104Fructose and mannose metabolism_Homo sapiens_hsa000510.47044233
105Inositol phosphate metabolism_Homo sapiens_hsa005620.45595741
106MAPK signaling pathway_Homo sapiens_hsa040100.45388332
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44840120
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43287167
109Oocyte meiosis_Homo sapiens_hsa041140.41104966
110Parkinsons disease_Homo sapiens_hsa050120.40394643
111Insulin signaling pathway_Homo sapiens_hsa049100.40370232
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.39675814
113Choline metabolism in cancer_Homo sapiens_hsa052310.39183107
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36392232
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34290658
116African trypanosomiasis_Homo sapiens_hsa051430.33960354
117Mineral absorption_Homo sapiens_hsa049780.32539163
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31812418
119Phenylalanine metabolism_Homo sapiens_hsa003600.29086417
120Biosynthesis of amino acids_Homo sapiens_hsa012300.28872011
121Dorso-ventral axis formation_Homo sapiens_hsa043200.28180221
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27970882
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.26750277
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25772034
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25169813
126Alcoholism_Homo sapiens_hsa050340.24237817
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23439460
128Huntingtons disease_Homo sapiens_hsa050160.22560066
129Complement and coagulation cascades_Homo sapiens_hsa046100.22440513
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21595889
131Ras signaling pathway_Homo sapiens_hsa040140.21375188
132Rheumatoid arthritis_Homo sapiens_hsa053230.20672654
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.20267528
134ABC transporters_Homo sapiens_hsa020100.19570487
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19284440

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