LIN7C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.48493309
2nucleobase catabolic process (GO:0046113)5.83808490
3layer formation in cerebral cortex (GO:0021819)4.80924076
4dendrite morphogenesis (GO:0048813)4.64718785
5axonal fasciculation (GO:0007413)4.17619993
6water-soluble vitamin biosynthetic process (GO:0042364)4.06595577
7postsynaptic membrane organization (GO:0001941)4.02168914
8COPI coating of Golgi vesicle (GO:0048205)3.97092053
9Golgi transport vesicle coating (GO:0048200)3.97092053
10dendritic spine morphogenesis (GO:0060997)3.95489134
11DNA double-strand break processing (GO:0000729)3.90383059
12axon extension (GO:0048675)3.84987206
13regulation of hexokinase activity (GO:1903299)3.82216367
14regulation of glucokinase activity (GO:0033131)3.82216367
15vesicle transport along microtubule (GO:0047496)3.74791842
16inositol phosphate catabolic process (GO:0071545)3.73156575
17central nervous system projection neuron axonogenesis (GO:0021952)3.72930747
18glial cell proliferation (GO:0014009)3.66628061
19neuron cell-cell adhesion (GO:0007158)3.66095470
20neuron recognition (GO:0008038)3.64444031
21presynaptic membrane assembly (GO:0097105)3.62653568
22clathrin coat assembly (GO:0048268)3.61352380
23neuron projection extension (GO:1990138)3.59857959
24organelle transport along microtubule (GO:0072384)3.59780376
25cell migration in hindbrain (GO:0021535)3.57882514
26lactate metabolic process (GO:0006089)3.53835090
27keratinocyte development (GO:0003334)3.50813071
28protein localization to cilium (GO:0061512)3.43785868
29respiratory chain complex IV assembly (GO:0008535)3.42021109
30inositol phosphate dephosphorylation (GO:0046855)3.37719100
31phosphorylated carbohydrate dephosphorylation (GO:0046838)3.37719100
32negative regulation of microtubule polymerization (GO:0031115)3.34078552
33regulation of synapse structural plasticity (GO:0051823)3.22360889
34regulation of cAMP-dependent protein kinase activity (GO:2000479)3.21306406
35adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.21018951
36protein prenylation (GO:0018342)3.19009391
37prenylation (GO:0097354)3.19009391
38inner ear receptor cell development (GO:0060119)3.17733486
39establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.17421746
40mitochondrion transport along microtubule (GO:0047497)3.17421746
41positive regulation of filopodium assembly (GO:0051491)3.16691200
42ER overload response (GO:0006983)3.16352332
43vesicle coating (GO:0006901)3.13450379
44synaptic vesicle maturation (GO:0016188)3.13117476
45protein localization to microtubule (GO:0035372)3.12897971
46central nervous system neuron axonogenesis (GO:0021955)3.11462858
47positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.09819089
48regulation of synaptic vesicle exocytosis (GO:2000300)3.07027206
49limb bud formation (GO:0060174)3.04548743
50regulation of short-term neuronal synaptic plasticity (GO:0048172)3.03875338
51cullin deneddylation (GO:0010388)3.03578012
52establishment of nucleus localization (GO:0040023)3.02012068
53polyol catabolic process (GO:0046174)3.01330846
54cellular ketone body metabolic process (GO:0046950)3.00955303
55presynaptic membrane organization (GO:0097090)2.99955468
56signal peptide processing (GO:0006465)2.98157113
57mitotic sister chromatid cohesion (GO:0007064)2.87916514
58ketone body metabolic process (GO:1902224)2.87418181
59cellular response to prostaglandin stimulus (GO:0071379)2.86887176
60regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.86378013
61cerebellum development (GO:0021549)2.84820602
62regulation of filopodium assembly (GO:0051489)2.84630600
63regulation of acyl-CoA biosynthetic process (GO:0050812)2.80749385
64positive regulation of axon extension (GO:0045773)2.80378463
65innervation (GO:0060384)2.79319345
66neuron migration (GO:0001764)2.79088558
67establishment of mitochondrion localization (GO:0051654)2.78803121
68positive regulation of protein autophosphorylation (GO:0031954)2.78463711
69synaptic vesicle docking involved in exocytosis (GO:0016081)2.77336528
70locomotory exploration behavior (GO:0035641)2.77008781
71microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.74714247
72cytochrome complex assembly (GO:0017004)2.72745724
73protein deneddylation (GO:0000338)2.72295168
74replication fork processing (GO:0031297)2.72181348
75synaptic vesicle exocytosis (GO:0016079)2.71981058
76proline transport (GO:0015824)2.71852518
77hippocampus development (GO:0021766)2.71623358
78exploration behavior (GO:0035640)2.71263963
79developmental cell growth (GO:0048588)2.70576713
80synapse assembly (GO:0007416)2.68041657
81cerebral cortex radially oriented cell migration (GO:0021799)2.67554855
82DNA topological change (GO:0006265)2.67466075
83regulation of axon extension (GO:0030516)2.66885295
84heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.66742599
85positive regulation of dendritic spine morphogenesis (GO:0061003)2.66334868
86vocalization behavior (GO:0071625)2.65603525
87response to pheromone (GO:0019236)2.64256341
88proteasome assembly (GO:0043248)2.63430922
89spindle assembly involved in mitosis (GO:0090307)2.62314519
90kidney morphogenesis (GO:0060993)2.62146773
91epithelial cell maturation (GO:0002070)2.61717427
92dendritic spine organization (GO:0097061)2.61613893
93protein K6-linked ubiquitination (GO:0085020)2.61500535
94protein K11-linked deubiquitination (GO:0035871)2.61365113
95regulation of neuron migration (GO:2001222)2.60211619
96anatomical structure arrangement (GO:0048532)2.60025439
97protein complex biogenesis (GO:0070271)2.59813235
98homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.59707430
99regulation of RNA export from nucleus (GO:0046831)2.59617183
100regulation of NFAT protein import into nucleus (GO:0051532)2.59393833
101magnesium ion transport (GO:0015693)2.59100806
102positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.58317815
103mitochondrial respiratory chain complex assembly (GO:0033108)2.56801925
104exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.56723242
105negative regulation of DNA-dependent DNA replication (GO:2000104)2.55759971
106auditory behavior (GO:0031223)2.55113463
107endocrine pancreas development (GO:0031018)2.54553898
108positive regulation of hormone biosynthetic process (GO:0046886)2.53345393
109dendrite development (GO:0016358)2.51331950
110regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.51158088
111intraciliary transport (GO:0042073)2.50381307
112protein targeting to Golgi (GO:0000042)2.50128311
113synapsis (GO:0007129)2.49744962
114righting reflex (GO:0060013)2.49352438
115glutamate secretion (GO:0014047)2.49281090
116positive regulation of protein depolymerization (GO:1901881)2.49262283
117apical protein localization (GO:0045176)2.49183532
118nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.48386477
119regulation of coenzyme metabolic process (GO:0051196)2.48289434
120regulation of cofactor metabolic process (GO:0051193)2.48289434
121regulation of meiosis I (GO:0060631)2.48244538
122dopamine receptor signaling pathway (GO:0007212)2.47590796
123establishment of protein localization to mitochondrial membrane (GO:0090151)2.47286854
124regulation of mitotic spindle checkpoint (GO:1903504)2.47165790
125regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.47165790
126regulation of sulfur metabolic process (GO:0042762)2.47087745
127regulation of Rac protein signal transduction (GO:0035020)2.45467325
128peptidyl-cysteine modification (GO:0018198)2.45213969
129positive regulation of glycolytic process (GO:0045821)2.44800157
130axonogenesis (GO:0007409)2.44582879
131negative regulation of axon extension involved in axon guidance (GO:0048843)2.44504132
132protein neddylation (GO:0045116)2.44480821
133generation of neurons (GO:0048699)2.44017834
134establishment of protein localization to Golgi (GO:0072600)2.43677672
135platelet dense granule organization (GO:0060155)2.43625812
136protein localization to synapse (GO:0035418)2.43566598
137negative regulation of glycogen biosynthetic process (GO:0045719)2.43446700
138regulation of axon extension involved in axon guidance (GO:0048841)2.43275765
139cerebellar granule cell differentiation (GO:0021707)2.43060301
140protein localization to microtubule cytoskeleton (GO:0072698)2.42174335
141regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.42132556
142regulation of glycogen (starch) synthase activity (GO:2000465)2.41819061
143ribonucleoprotein complex disassembly (GO:0032988)2.41780146
144regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.41142780
145regulation of glutamate receptor signaling pathway (GO:1900449)2.40874580
146nucleus localization (GO:0051647)2.40357830
147regulation of synaptic vesicle transport (GO:1902803)2.40107422
148regulation of microtubule polymerization (GO:0031113)2.39897112
149regulation of type B pancreatic cell apoptotic process (GO:2000674)2.39586942
150protein-cofactor linkage (GO:0018065)2.39443406
151regulation of axon guidance (GO:1902667)2.38417218
152brain morphogenesis (GO:0048854)2.38405721
153nerve growth factor signaling pathway (GO:0038180)2.38385145
154negative regulation of neurological system process (GO:0031645)2.38196905
155behavioral response to nicotine (GO:0035095)2.38153694
156organelle disassembly (GO:1903008)2.37351106
157G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.36149267
158L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.36106854
159branched-chain amino acid catabolic process (GO:0009083)2.35242050
160detection of calcium ion (GO:0005513)2.32939177
161histone H2A acetylation (GO:0043968)2.32391253
162RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.30768575
163L-fucose catabolic process (GO:0042355)2.30317828
164fucose catabolic process (GO:0019317)2.30317828
165L-fucose metabolic process (GO:0042354)2.30317828
166reflex (GO:0060004)2.30297683
167S-adenosylmethionine metabolic process (GO:0046500)2.29805527
168atrial cardiac muscle cell action potential (GO:0086014)2.27702277
169somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.26263798
170isotype switching (GO:0045190)2.26263798
171somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.26263798
172negative regulation of cytosolic calcium ion concentration (GO:0051481)2.26199257
173neural tube formation (GO:0001841)2.23374836
174regulation of feeding behavior (GO:0060259)2.23160481
175insulin secretion (GO:0030073)2.23098760
176positive regulation of mRNA processing (GO:0050685)2.22588808
177mitochondrial respiratory chain complex I assembly (GO:0032981)2.21285877
178NADH dehydrogenase complex assembly (GO:0010257)2.21285877
179mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.21285877
180resolution of meiotic recombination intermediates (GO:0000712)2.21037304
181negative regulation of JUN kinase activity (GO:0043508)2.20001818
182anterograde synaptic vesicle transport (GO:0048490)2.18768228
183glycerophospholipid catabolic process (GO:0046475)2.18309655
184glycosphingolipid biosynthetic process (GO:0006688)2.16622373
185zinc ion transport (GO:0006829)2.15355893
186cilium organization (GO:0044782)2.14825495
187preassembly of GPI anchor in ER membrane (GO:0016254)2.14376232
188nonmotile primary cilium assembly (GO:0035058)2.13833483
189prostate gland growth (GO:0060736)2.13782627
190cilium assembly (GO:0042384)2.13436052
191maturation of 5.8S rRNA (GO:0000460)2.13205068
192peptidyl-histidine modification (GO:0018202)2.11927374
193negative regulation of membrane potential (GO:0045837)2.11131051
194dopamine transport (GO:0015872)2.09247567

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.05330958
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.79818601
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.31188167
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.02784027
5EZH2_22144423_ChIP-Seq_EOC_Human2.83475471
6GBX2_23144817_ChIP-Seq_PC3_Human2.75353245
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.59432522
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.56058858
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.53015956
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.49666423
11VDR_22108803_ChIP-Seq_LS180_Human2.31952646
12TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.26024162
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.24439724
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.18188818
15ZNF217_24962896_ChIP-Seq_MCF-7_Human2.09858589
16ELK1_19687146_ChIP-ChIP_HELA_Human2.05690388
17ZNF274_21170338_ChIP-Seq_K562_Hela2.05652999
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.00156889
19* GABP_17652178_ChIP-ChIP_JURKAT_Human1.99096598
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97444568
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96746540
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96005769
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94902832
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93795486
25OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.92339122
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.91329629
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90434287
28SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.86466842
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86120391
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.83240938
31HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.79897938
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.79850408
33FUS_26573619_Chip-Seq_HEK293_Human1.79097732
34AR_21572438_ChIP-Seq_LNCaP_Human1.78762554
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72773152
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66606640
37EWS_26573619_Chip-Seq_HEK293_Human1.66529663
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64939958
39SMAD4_21799915_ChIP-Seq_A2780_Human1.63821664
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63210395
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62392035
42P300_19829295_ChIP-Seq_ESCs_Human1.61571981
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59898563
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.58553970
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56648179
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56249531
47ARNT_22903824_ChIP-Seq_MCF-7_Human1.55948512
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55113805
49PKCTHETA_26484144_Chip-Seq_BREAST_Human1.54885019
50REST_21632747_ChIP-Seq_MESCs_Mouse1.53367760
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.53080242
52RNF2_27304074_Chip-Seq_NSC_Mouse1.52970719
53AHR_22903824_ChIP-Seq_MCF-7_Human1.52226867
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.51653128
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51487199
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.48332916
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46366986
58CBP_20019798_ChIP-Seq_JUKART_Human1.46366986
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45754322
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.45498966
61YAP1_20516196_ChIP-Seq_MESCs_Mouse1.44837146
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44175858
63TAF15_26573619_Chip-Seq_HEK293_Human1.43867344
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42041295
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39820162
66BCAT_22108803_ChIP-Seq_LS180_Human1.39173423
67STAT3_23295773_ChIP-Seq_U87_Human1.37636361
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37288121
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.35112550
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.34418725
71TP53_18474530_ChIP-ChIP_U2OS_Human1.31148909
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29773872
73ER_23166858_ChIP-Seq_MCF-7_Human1.29338238
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29242950
75VDR_23849224_ChIP-Seq_CD4+_Human1.28518511
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26036974
77FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.25711944
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.25693861
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25372150
80* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25180249
81IGF1R_20145208_ChIP-Seq_DFB_Human1.25045088
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24521849
83SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.24086700
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23731482
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22075022
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22075022
87TCF4_18268006_ChIP-ChIP_LS174T_Human1.21391337
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21105463
89* P53_22387025_ChIP-Seq_ESCs_Mouse1.20940107
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.20931004
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20303328
92TCF4_22108803_ChIP-Seq_LS180_Human1.19832122
93E2F4_17652178_ChIP-ChIP_JURKAT_Human1.19112665
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18082809
95SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17080375
96RUNX2_22187159_ChIP-Seq_PCA_Human1.16554990
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16237017
98* E2F1_18555785_Chip-Seq_ESCs_Mouse1.16132565
99TP53_22573176_ChIP-Seq_HFKS_Human1.15960864
100AR_25329375_ChIP-Seq_VCAP_Human1.15881197
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.15820152
102SOX2_19829295_ChIP-Seq_ESCs_Human1.14989954
103NANOG_19829295_ChIP-Seq_ESCs_Human1.14989954
104CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14964383
105CDX2_22108803_ChIP-Seq_LS180_Human1.14793407
106* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14688062
107* CMYC_18555785_Chip-Seq_ESCs_Mouse1.14684626
108AR_19668381_ChIP-Seq_PC3_Human1.14071091
109SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13917856
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13354418
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.13204056
112SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12194266
113* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12155426
114MYC_18940864_ChIP-ChIP_HL60_Human1.11890571
115HTT_18923047_ChIP-ChIP_STHdh_Human1.11780126
116POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11625158
117NOTCH1_21737748_ChIP-Seq_TLL_Human1.11078250
118FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10653913
119RNF2_27304074_Chip-Seq_ESCs_Mouse1.10604690
120TCF4_23295773_ChIP-Seq_U87_Human1.10487417
121EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09335725
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08471741
123REST_18959480_ChIP-ChIP_MESCs_Mouse1.08195509
124* P300_18555785_Chip-Seq_ESCs_Mouse1.08094709
125RARB_27405468_Chip-Seq_BRAIN_Mouse1.07946527
126* STAT3_18555785_Chip-Seq_ESCs_Mouse1.07391336
127EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07228477
128RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07228477
129TP53_16413492_ChIP-PET_HCT116_Human1.06713348
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06666147
131WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06375451
132FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05924335
133REST_19997604_ChIP-ChIP_NEURONS_Mouse1.05762779
134P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05680143
135SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05659135
136SMAD3_21741376_ChIP-Seq_ESCs_Human1.05190495
137* CBX2_27304074_Chip-Seq_ESCs_Mouse1.05019310
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04940068
139JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04207265
140EED_16625203_ChIP-ChIP_MESCs_Mouse1.03950824
141* NANOG_18555785_Chip-Seq_ESCs_Mouse1.02824765
142EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02102347
143* SOX2_18555785_Chip-Seq_ESCs_Mouse1.01122407
144RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99426441
145JUN_21703547_ChIP-Seq_K562_Human0.99367828
146CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99300419
147GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98514925
148TAL1_26923725_Chip-Seq_HPCs_Mouse0.98189149
149OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98160982
150UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97678904
151POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.97514004
152CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96664832

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.60255952
2MP0008877_abnormal_DNA_methylation3.03460063
3MP0005187_abnormal_penis_morphology2.95812146
4MP0000778_abnormal_nervous_system2.93593572
5MP0004270_analgesia2.93257493
6MP0003195_calcinosis2.84377271
7MP0009780_abnormal_chondrocyte_physiolo2.68000466
8MP0002837_dystrophic_cardiac_calcinosis2.63628372
9MP0004859_abnormal_synaptic_plasticity2.53447721
10MP0000569_abnormal_digit_pigmentation2.42931720
11MP0003890_abnormal_embryonic-extraembry2.16201120
12MP0000537_abnormal_urethra_morphology2.11563920
13MP0003787_abnormal_imprinting2.00909190
14MP0009046_muscle_twitch2.00683846
15MP0002877_abnormal_melanocyte_morpholog1.98464774
16MP0006072_abnormal_retinal_apoptosis1.93418584
17MP0008057_abnormal_DNA_replication1.91945583
18MP0002734_abnormal_mechanical_nocicepti1.91774538
19MP0002063_abnormal_learning/memory/cond1.90075704
20MP0001529_abnormal_vocalization1.89447552
21MP0008789_abnormal_olfactory_epithelium1.88333100
22MP0002234_abnormal_pharynx_morphology1.87777791
23MP0002184_abnormal_innervation1.87509201
24MP0003880_abnormal_central_pattern1.83554788
25MP0001984_abnormal_olfaction1.82997327
26MP0005367_renal/urinary_system_phenotyp1.80894430
27MP0000516_abnormal_urinary_system1.80894430
28MP0003635_abnormal_synaptic_transmissio1.80633019
29MP0008058_abnormal_DNA_repair1.79465856
30MP0002009_preneoplasia1.79128406
31MP0005423_abnormal_somatic_nervous1.75112366
32MP0002909_abnormal_adrenal_gland1.70363706
33MP0005379_endocrine/exocrine_gland_phen1.64792922
34MP0005645_abnormal_hypothalamus_physiol1.64419265
35MP0003119_abnormal_digestive_system1.61396028
36MP0000631_abnormal_neuroendocrine_gland1.61250971
37MP0001299_abnormal_eye_distance/1.58810916
38MP0004811_abnormal_neuron_physiology1.58791694
39MP0010352_gastrointestinal_tract_polyps1.58092819
40MP0002938_white_spotting1.57770522
41MP0000372_irregular_coat_pigmentation1.57282313
42MP0005084_abnormal_gallbladder_morpholo1.57116698
43MP0002557_abnormal_social/conspecific_i1.55899654
44MP0003121_genomic_imprinting1.54551644
45MP0003718_maternal_effect1.49629157
46MP0003183_abnormal_peptide_metabolism1.48713380
47MP0002638_abnormal_pupillary_reflex1.46222055
48MP0010678_abnormal_skin_adnexa1.42812462
49MP0002896_abnormal_bone_mineralization1.41411701
50MP0005248_abnormal_Harderian_gland1.39051646
51MP0003861_abnormal_nervous_system1.38090933
52MP0003786_premature_aging1.37534282
53MP0004043_abnormal_pH_regulation1.36422378
54MP0005076_abnormal_cell_differentiation1.34794215
55MP0000462_abnormal_digestive_system1.34361976
56MP0005394_taste/olfaction_phenotype1.33653308
57MP0005499_abnormal_olfactory_system1.33653308
58MP0006276_abnormal_autonomic_nervous1.33426022
59MP0002163_abnormal_gland_morphology1.33102002
60MP0006035_abnormal_mitochondrial_morpho1.29797667
61MP0004885_abnormal_endolymph1.27635572
62MP0005646_abnormal_pituitary_gland1.27327174
63MP0000955_abnormal_spinal_cord1.27285884
64MP0001177_atelectasis1.26065349
65MP0004142_abnormal_muscle_tone1.25640035
66MP0002272_abnormal_nervous_system1.25475146
67MP0004147_increased_porphyrin_level1.24968011
68MP0002152_abnormal_brain_morphology1.23818607
69MP0009697_abnormal_copulation1.22239544
70MP0002572_abnormal_emotion/affect_behav1.20996330
71MP0002882_abnormal_neuron_morphology1.20011350
72MP0002876_abnormal_thyroid_physiology1.19951805
73MP0004215_abnormal_myocardial_fiber1.17898378
74MP0001944_abnormal_pancreas_morphology1.16119552
75MP0002736_abnormal_nociception_after1.15622797
76MP0003123_paternal_imprinting1.14334432
77MP0002160_abnormal_reproductive_system1.11448628
78MP0003283_abnormal_digestive_organ1.10800887
79MP0005253_abnormal_eye_physiology1.09316418
80MP0004924_abnormal_behavior1.08869763
81MP0005386_behavior/neurological_phenoty1.08869763
82MP0001188_hyperpigmentation1.08306764
83MP0010386_abnormal_urinary_bladder1.07699418
84MP0002733_abnormal_thermal_nociception1.05860791
85MP0002928_abnormal_bile_duct1.04568909
86MP0002233_abnormal_nose_morphology1.02941904
87MP0001502_abnormal_circadian_rhythm1.02803038
88MP0000013_abnormal_adipose_tissue1.02399178
89MP0003755_abnormal_palate_morphology1.02323377
90MP0000647_abnormal_sebaceous_gland1.01772919
91MP0003300_gastrointestinal_ulcer1.00788983
92MP0003011_delayed_dark_adaptation1.00170829
93MP0009703_decreased_birth_body0.98889471
94MP0003122_maternal_imprinting0.98818998
95MP0003315_abnormal_perineum_morphology0.96472037
96MP0001486_abnormal_startle_reflex0.95685169
97MP0005332_abnormal_amino_acid0.95637335
98MP0003937_abnormal_limbs/digits/tail_de0.94571095
99MP0004133_heterotaxia0.94392315
100MP0002751_abnormal_autonomic_nervous0.94070403
101MP0002081_perinatal_lethality0.93673434
102MP0010094_abnormal_chromosome_stability0.93492390
103MP0009745_abnormal_behavioral_response0.93217571
104MP0008875_abnormal_xenobiotic_pharmacok0.93113717
105MP0005551_abnormal_eye_electrophysiolog0.92560119
106MP0002064_seizures0.91645408
107MP0002735_abnormal_chemical_nociception0.91583274
108MP0006054_spinal_hemorrhage0.89896122
109MP0003935_abnormal_craniofacial_develop0.89841399
110MP0002084_abnormal_developmental_patter0.86947315
111MP0006036_abnormal_mitochondrial_physio0.86683811
112MP0005220_abnormal_exocrine_pancreas0.86147718
113MP0000383_abnormal_hair_follicle0.85973334
114MP0008872_abnormal_physiological_respon0.85947347
115MP0009053_abnormal_anal_canal0.85394294
116MP0000681_abnormal_thyroid_gland0.84349872
117MP0008995_early_reproductive_senescence0.84168700
118MP0001485_abnormal_pinna_reflex0.83344058
119MP0005389_reproductive_system_phenotype0.82783880
120MP0000534_abnormal_ureter_morphology0.81519109
121MP0001348_abnormal_lacrimal_gland0.81430720
122MP0002822_catalepsy0.80787413
123MP0005391_vision/eye_phenotype0.80628291
124MP0002090_abnormal_vision0.80501377
125MP0002693_abnormal_pancreas_physiology0.80289341
126MP0000427_abnormal_hair_cycle0.80032638
127MP0002067_abnormal_sensory_capabilities0.79022105
128MP0002102_abnormal_ear_morphology0.78927876
129MP0002116_abnormal_craniofacial_bone0.78841765
130MP0005174_abnormal_tail_pigmentation0.78663232
131MP0001764_abnormal_homeostasis0.78334567
132MP0001286_abnormal_eye_development0.78204863
133MP0004858_abnormal_nervous_system0.78021720
134MP0001968_abnormal_touch/_nociception0.77913385
135MP0003634_abnormal_glial_cell0.77850215
136MP0004264_abnormal_extraembryonic_tissu0.77632256
137MP0004085_abnormal_heartbeat0.76973078
138MP0000613_abnormal_salivary_gland0.76937726
139MP0002229_neurodegeneration0.76729577
140MP0000579_abnormal_nail_morphology0.76225097
141MP0004742_abnormal_vestibular_system0.75742310
142MP0002177_abnormal_outer_ear0.75730128
143MP0002098_abnormal_vibrissa_morphology0.72912324
144MP0001293_anophthalmia0.72720561

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)4.02684384
2Hypothermia (HP:0002045)3.80095423
3Amyotrophic lateral sclerosis (HP:0007354)3.78019771
4Drooling (HP:0002307)3.32094586
5Excessive salivation (HP:0003781)3.32094586
6Inappropriate behavior (HP:0000719)3.13440211
7Medial flaring of the eyebrow (HP:0010747)2.98793148
8Volvulus (HP:0002580)2.95202107
9Intestinal atresia (HP:0011100)2.90540433
10Hyperinsulinemic hypoglycemia (HP:0000825)2.87960687
11Pancreatic cysts (HP:0001737)2.85531449
12Hypoglycemic coma (HP:0001325)2.84310483
13Agitation (HP:0000713)2.83579055
14Thyroid carcinoma (HP:0002890)2.83295520
15Protruding tongue (HP:0010808)2.82994971
16Mutism (HP:0002300)2.75949046
17Progressive macrocephaly (HP:0004481)2.74907576
18Disinhibition (HP:0000734)2.74031145
19Shoulder girdle muscle weakness (HP:0003547)2.73994785
20Insidious onset (HP:0003587)2.73025745
21Termporal pattern (HP:0011008)2.73025745
22Methylmalonic acidemia (HP:0002912)2.72618333
23Pancreatic fibrosis (HP:0100732)2.71481553
24Papilledema (HP:0001085)2.70703776
25Cortical dysplasia (HP:0002539)2.70475688
26Atrophy/Degeneration involving motor neurons (HP:0007373)2.68219191
27Aqueductal stenosis (HP:0002410)2.65360765
28Hepatoblastoma (HP:0002884)2.59889947
29True hermaphroditism (HP:0010459)2.59841238
30Hypoglycemic seizures (HP:0002173)2.56151352
31Neoplasm of the adrenal cortex (HP:0100641)2.55062060
32Hyperglycemia (HP:0003074)2.53892837
33Acute necrotizing encephalopathy (HP:0006965)2.50580842
34Limb dystonia (HP:0002451)2.47428449
35Abnormality of midbrain morphology (HP:0002418)2.46635768
36Molar tooth sign on MRI (HP:0002419)2.46635768
37Abnormality of the corticospinal tract (HP:0002492)2.44898973
38Increased hepatocellular lipid droplets (HP:0006565)2.42672617
39Megalencephaly (HP:0001355)2.39132515
40Abnormality of vitamin B metabolism (HP:0004340)2.38567248
41Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.37782400
42Nephronophthisis (HP:0000090)2.34299030
43Congenital primary aphakia (HP:0007707)2.34004561
44Gait imbalance (HP:0002141)2.33259787
45Acute encephalopathy (HP:0006846)2.32000611
46Neuroendocrine neoplasm (HP:0100634)2.30427605
47Macroorchidism (HP:0000053)2.28807113
48Increased CSF lactate (HP:0002490)2.25784495
49Ketoacidosis (HP:0001993)2.25506796
50Pachygyria (HP:0001302)2.25479942
51Progressive inability to walk (HP:0002505)2.23318944
52Hyperventilation (HP:0002883)2.22120567
53Lipid accumulation in hepatocytes (HP:0006561)2.21893380
54Abnormality of the renal cortex (HP:0011035)2.21291348
55Renal cortical cysts (HP:0000803)2.21015657
56Visual hallucinations (HP:0002367)2.20890306
57Large for gestational age (HP:0001520)2.20381166
58Subacute progressive viral hepatitis (HP:0006572)2.20035042
59Akinesia (HP:0002304)2.18560290
60Transitional cell carcinoma of the bladder (HP:0006740)2.16400560
61Nephrogenic diabetes insipidus (HP:0009806)2.16277265
62Hypomagnesemia (HP:0002917)2.14235170
63Lissencephaly (HP:0001339)2.14041115
64Abnormality of salivation (HP:0100755)2.13011610
65Hypsarrhythmia (HP:0002521)2.12450722
66Muscular hypotonia of the trunk (HP:0008936)2.12247051
67EEG with generalized epileptiform discharges (HP:0011198)2.11374790
68Mitochondrial inheritance (HP:0001427)2.10282533
69Pancreatic islet-cell hyperplasia (HP:0004510)2.10111338
70Asymmetry of the thorax (HP:0001555)2.10064791
71Adrenal hypoplasia (HP:0000835)2.07957697
72Aplasia/Hypoplasia of the fovea (HP:0008060)2.07811260
73Hypoplasia of the fovea (HP:0007750)2.07811260
74Abnormality of methionine metabolism (HP:0010901)2.06888133
75Exostoses (HP:0100777)2.06369264
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.06144772
77Abnormality of the labia minora (HP:0012880)2.06050151
78Epileptiform EEG discharges (HP:0011182)2.05813265
79Bladder carcinoma (HP:0002862)2.05469920
80Bladder neoplasm (HP:0009725)2.05469920
81Colon cancer (HP:0003003)2.04664206
82Cutaneous finger syndactyly (HP:0010554)2.04460600
83Broad-based gait (HP:0002136)2.04326980
84Gaze-evoked nystagmus (HP:0000640)2.02794173
85Abnormality of endocrine pancreas physiology (HP:0012093)2.02416180
86Abnormality of the pancreatic islet cells (HP:0006476)2.02416180
87Hyperthyroidism (HP:0000836)2.02258145
88Abnormal mitochondria in muscle tissue (HP:0008316)2.02156024
89Apathy (HP:0000741)2.01884160
90Methylmalonic aciduria (HP:0012120)2.01194955
91Abnormality of alanine metabolism (HP:0010916)2.01039323
92Hyperalaninemia (HP:0003348)2.01039323
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01039323
94Vaginal atresia (HP:0000148)2.00590084
95Prominent metopic ridge (HP:0005487)1.98743724
96Abnormality of the renal medulla (HP:0100957)1.97432942
97Hemiparesis (HP:0001269)1.96905831
98Furrowed tongue (HP:0000221)1.94812471
99Abnormality of the metopic suture (HP:0005556)1.94292265
100Renal hypoplasia (HP:0000089)1.93997667
101Lower limb asymmetry (HP:0100559)1.92929637
102Abnormality of the fovea (HP:0000493)1.92823998
103Abnormality of the lower motor neuron (HP:0002366)1.92243679
104Exotropia (HP:0000577)1.91527259
105Ankyloglossia (HP:0010296)1.90081815
1063-Methylglutaconic aciduria (HP:0003535)1.89070747
107Facial hemangioma (HP:0000329)1.89057750
108Absent eyebrow (HP:0002223)1.88513416
109Intellectual disability, profound (HP:0002187)1.86897026
110Hamartoma of the eye (HP:0010568)1.86517006
111Chronic hepatic failure (HP:0100626)1.86073032
112Abnormality of the vitamin B12 metabolism (HP:0004341)1.86055017
113Genetic anticipation (HP:0003743)1.85400448
114Thyroiditis (HP:0100646)1.84377673
115Type II lissencephaly (HP:0007260)1.83751882
116Aplasia/Hypoplasia of the sternum (HP:0006714)1.83381835
117Congenital stationary night blindness (HP:0007642)1.83285860
118Abnormality of the astrocytes (HP:0100707)1.83104041
119Astrocytoma (HP:0009592)1.83104041
120Diminished motivation (HP:0000745)1.82672579
121Increased number of teeth (HP:0011069)1.81513158
122Aplasia/Hypoplasia of the tibia (HP:0005772)1.80771579
123Hepatic necrosis (HP:0002605)1.80611869
124Cerebral edema (HP:0002181)1.80447484
125Abnormality of urine glucose concentration (HP:0011016)1.79933859
126Glycosuria (HP:0003076)1.79933859
127Generalized myoclonic seizures (HP:0002123)1.79751565
128Spinal muscular atrophy (HP:0007269)1.79533602
129Breast carcinoma (HP:0003002)1.79099527
130Short tibia (HP:0005736)1.77885409
131Morphological abnormality of the pyramidal tract (HP:0002062)1.77367731
132Neoplasm of the adrenal gland (HP:0100631)1.77198759
133Open mouth (HP:0000194)1.75837409
134Disproportionate short-trunk short stature (HP:0003521)1.75209342
135Inability to walk (HP:0002540)1.74604503
136Generalized hypopigmentation of hair (HP:0011358)1.74489918
137Renal Fanconi syndrome (HP:0001994)1.74243079
138Ependymoma (HP:0002888)1.74170156
139Cutaneous syndactyly (HP:0012725)1.73153276
140Epileptic encephalopathy (HP:0200134)1.72656869
141Aplasia/Hypoplasia of the tongue (HP:0010295)1.72342043
142Pheochromocytoma (HP:0002666)1.71895773
143Abnormality of the pons (HP:0007361)1.71570286
144Heterotopia (HP:0002282)1.70756209
145Aplasia/Hypoplasia of the brainstem (HP:0007362)1.69311434
146Hypoplasia of the brainstem (HP:0002365)1.69311434
147Abnormality of vitamin metabolism (HP:0100508)1.69129111
148Symptomatic seizures (HP:0011145)1.69001822
149Neoplasm of the thyroid gland (HP:0100031)1.67599018
150Tongue fasciculations (HP:0001308)1.67557361
151Polyphagia (HP:0002591)1.67402908
152Delayed gross motor development (HP:0002194)1.67235900
153Pelvic girdle muscle weakness (HP:0003749)1.65993270
154Relative macrocephaly (HP:0004482)1.65751093
155Truncal obesity (HP:0001956)1.65606242
156Truncal ataxia (HP:0002078)1.65529989
157Glioma (HP:0009733)1.64467655
158Choroideremia (HP:0001139)1.64234343
159Rimmed vacuoles (HP:0003805)1.63983441
160Abnormality of chromosome segregation (HP:0002916)1.63139322
161Leiomyosarcoma (HP:0100243)1.62912659
162Uterine leiomyosarcoma (HP:0002891)1.62912659
163Vitreoretinal degeneration (HP:0000655)1.62872717
164Progressive cerebellar ataxia (HP:0002073)1.62769388
165Dyschromatopsia (HP:0007641)1.62494554
166Urinary urgency (HP:0000012)1.62295256
167Abnormal pancreas size (HP:0012094)1.61603420
168Sacral dimple (HP:0000960)1.61085279
169Ankle clonus (HP:0011448)1.60796808
170Curly hair (HP:0002212)1.60707634
171Omphalocele (HP:0001539)1.59158449
172Genital tract atresia (HP:0001827)1.58187088
173Specific learning disability (HP:0001328)1.58055157
174Blue irides (HP:0000635)1.54728431
175Posterior subcapsular cataract (HP:0007787)1.53898208
176Abnormality of macular pigmentation (HP:0008002)1.53764486
177Cerebral inclusion bodies (HP:0100314)1.52367500
178Restlessness (HP:0000711)1.52033393
179Lymphangioma (HP:0100764)1.50916239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK17.37923523
2ERBB33.97024103
3FRK3.45938748
4MAP3K92.88305246
5TRIM282.79678546
6DYRK22.79201689
7MAPK132.56467035
8EIF2AK32.49831970
9CASK2.27544157
10MAP4K22.13630340
11KSR12.09717716
12NTRK22.08358103
13NUAK11.92583991
14MAP3K41.90441633
15ZAK1.89931854
16BCR1.84674323
17NTRK31.82381886
18TSSK61.79187770
19ACVR1B1.76941864
20MAP3K21.71541602
21MINK11.65496866
22FGFR21.63030241
23BRSK21.55030737
24EIF2AK11.52636708
25CSNK1G21.50362365
26WNK31.49228872
27PLK31.45934746
28GRK11.45934189
29PLK21.45855251
30STK391.42171872
31SCYL21.40627126
32PAK31.36439297
33MAP2K71.28698876
34OXSR11.27549828
35CSNK1A1L1.27242265
36NEK11.19186823
37ADRBK21.18343753
38LIMK11.14942649
39UHMK11.14612389
40PINK11.14086559
41CSNK1G31.12065372
42STK38L1.07803791
43STK31.05763573
44PASK1.04914353
45PHKG11.03509974
46PHKG21.03509974
47SGK21.02880096
48DYRK1A1.02830319
49SRPK11.02003377
50BUB10.99220058
51PBK0.95355884
52CDK50.94810736
53STK160.94099940
54INSRR0.93485725
55STK240.90728270
56NLK0.89191108
57DYRK1B0.89067205
58PDGFRA0.88693462
59PNCK0.88403007
60RPS6KA20.87256411
61CSNK1G10.87125711
62VRK10.86302955
63SGK4940.84020965
64SGK2230.84020965
65LATS10.82389590
66AKT30.80589811
67KSR20.80414957
68FER0.78540255
69CCNB10.75987963
70PLK40.75115505
71MAP3K120.74137722
72LATS20.73783760
73YES10.70987295
74PRKCG0.70037633
75SGK30.69789129
76BMPR1B0.69245864
77WEE10.68848855
78RET0.68187502
79PAK60.67693296
80WNK40.67209969
81CAMKK20.66446344
82PLK10.66330442
83RPS6KB10.65106543
84CDK140.64707933
85PRKCE0.64351405
86EPHB20.64322631
87EPHA30.62982861
88LMTK20.62756742
89TAF10.61416834
90HIPK20.60039552
91PRKD30.59881562
92TTK0.58808273
93PRKCI0.57605178
94FGFR30.56889406
95CDK180.56693067
96PKN10.54129379
97TESK10.53425361
98TLK10.53182324
99FGFR10.52924003
100CDC70.52103704
101EEF2K0.51913088
102SIK20.51148384
103PDGFRB0.50396517
104CDK60.49985602
105CDK150.49429485
106CAMK2A0.48789071
107MAPK90.48208519
108MAP2K40.47443483
109ATM0.47436618
110SGK10.47264994
111MKNK20.46573895
112DAPK20.46473738
113CAMKK10.45839038
114NME10.45171184
115MAP2K10.45100035
116CSNK1D0.44045676
117NTRK10.43874503
118ERBB40.43854618
119PIK3CA0.43660277
120CHEK20.43292981
121MAP3K60.42995184
122PRKCZ0.42799438
123ADRBK10.41860829
124PDK20.41718481
125TNIK0.41694087
126EIF2AK20.40908871
127GSK3A0.40474117
128RPS6KA40.40371990
129RIPK10.39505350
130MST40.39264562
131ROCK10.38782040
132CSNK1E0.37534407
133CAMK2D0.36238683
134PRKAA10.36133605
135MKNK10.35750117
136PTK60.35587597
137CDK10.35242739
138DYRK30.35189538
139PRKDC0.34822244
140TRPM70.34780788
141ALK0.34613040
142BRSK10.34282186
143RPS6KA50.34062094
144SIK30.33396068
145CAMK2B0.33366447
146TGFBR10.33244824
147PRKACB0.33199983
148CSNK1A10.32859156
149BMPR20.29326566

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.46337525
2Butanoate metabolism_Homo sapiens_hsa006502.30803429
3Vitamin B6 metabolism_Homo sapiens_hsa007502.12555269
4Oxidative phosphorylation_Homo sapiens_hsa001902.10209952
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05771318
6Axon guidance_Homo sapiens_hsa043602.05646671
7Non-homologous end-joining_Homo sapiens_hsa034502.03265100
8Propanoate metabolism_Homo sapiens_hsa006402.02827014
9Proteasome_Homo sapiens_hsa030502.01395993
10Basal transcription factors_Homo sapiens_hsa030221.99157863
11Dopaminergic synapse_Homo sapiens_hsa047281.93281792
12Endometrial cancer_Homo sapiens_hsa052131.89877852
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88699886
14Phototransduction_Homo sapiens_hsa047441.88527897
15Olfactory transduction_Homo sapiens_hsa047401.88255925
16Selenocompound metabolism_Homo sapiens_hsa004501.87355498
17Circadian entrainment_Homo sapiens_hsa047131.76795229
18Colorectal cancer_Homo sapiens_hsa052101.76707559
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.70945267
20Long-term potentiation_Homo sapiens_hsa047201.69105124
21Type II diabetes mellitus_Homo sapiens_hsa049301.67125964
22Collecting duct acid secretion_Homo sapiens_hsa049661.65057485
23Insulin secretion_Homo sapiens_hsa049111.58936062
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58626915
25Cholinergic synapse_Homo sapiens_hsa047251.57625460
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56871435
27RNA degradation_Homo sapiens_hsa030181.53614675
28Synaptic vesicle cycle_Homo sapiens_hsa047211.51983216
29GABAergic synapse_Homo sapiens_hsa047271.48999412
30Parkinsons disease_Homo sapiens_hsa050121.48472973
31Amphetamine addiction_Homo sapiens_hsa050311.47583491
32Alcoholism_Homo sapiens_hsa050341.46174400
33Fanconi anemia pathway_Homo sapiens_hsa034601.44907699
34Renal cell carcinoma_Homo sapiens_hsa052111.44300989
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41592619
36RNA polymerase_Homo sapiens_hsa030201.40865038
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.40289264
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39678499
39Glutamatergic synapse_Homo sapiens_hsa047241.39543078
40Fatty acid elongation_Homo sapiens_hsa000621.39139141
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38710478
42Regulation of autophagy_Homo sapiens_hsa041401.37814536
43Serotonergic synapse_Homo sapiens_hsa047261.35790027
44Oocyte meiosis_Homo sapiens_hsa041141.34002223
45Cocaine addiction_Homo sapiens_hsa050301.32119600
46ErbB signaling pathway_Homo sapiens_hsa040121.32086810
47Peroxisome_Homo sapiens_hsa041461.31852617
48Nicotine addiction_Homo sapiens_hsa050331.31696208
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27243612
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26639903
51Glioma_Homo sapiens_hsa052141.25319015
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24570579
53Estrogen signaling pathway_Homo sapiens_hsa049151.24505487
54Homologous recombination_Homo sapiens_hsa034401.21875879
55Hippo signaling pathway_Homo sapiens_hsa043901.19713603
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19687649
57Caffeine metabolism_Homo sapiens_hsa002321.18512458
58Morphine addiction_Homo sapiens_hsa050321.18323921
59Ether lipid metabolism_Homo sapiens_hsa005651.18229453
60mTOR signaling pathway_Homo sapiens_hsa041501.18078099
61Vibrio cholerae infection_Homo sapiens_hsa051101.17886582
62Tryptophan metabolism_Homo sapiens_hsa003801.16712940
63Mismatch repair_Homo sapiens_hsa034301.15165130
64Nitrogen metabolism_Homo sapiens_hsa009101.11439062
65Long-term depression_Homo sapiens_hsa047301.10904146
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10815767
67Gap junction_Homo sapiens_hsa045401.10621857
68N-Glycan biosynthesis_Homo sapiens_hsa005101.09648059
69Adherens junction_Homo sapiens_hsa045201.08858848
70Prolactin signaling pathway_Homo sapiens_hsa049171.08800016
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04273872
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03497168
73Sulfur metabolism_Homo sapiens_hsa009201.03483163
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03088755
75Cysteine and methionine metabolism_Homo sapiens_hsa002701.02950597
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01786350
77Pancreatic cancer_Homo sapiens_hsa052121.01483646
78GnRH signaling pathway_Homo sapiens_hsa049121.01450727
79RNA transport_Homo sapiens_hsa030131.00773656
80Renin secretion_Homo sapiens_hsa049241.00443466
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99603522
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99124170
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98480567
84Folate biosynthesis_Homo sapiens_hsa007900.98374601
85Melanogenesis_Homo sapiens_hsa049160.97491530
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.96876438
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95844431
88Nucleotide excision repair_Homo sapiens_hsa034200.95596011
89Alzheimers disease_Homo sapiens_hsa050100.95531052
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.94960189
91Wnt signaling pathway_Homo sapiens_hsa043100.94910713
92One carbon pool by folate_Homo sapiens_hsa006700.94436308
93Circadian rhythm_Homo sapiens_hsa047100.92726126
94Huntingtons disease_Homo sapiens_hsa050160.92535300
95MicroRNAs in cancer_Homo sapiens_hsa052060.92436667
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90868402
97Tight junction_Homo sapiens_hsa045300.90433900
98Prostate cancer_Homo sapiens_hsa052150.89573479
99Taste transduction_Homo sapiens_hsa047420.89390235
100Protein export_Homo sapiens_hsa030600.88897279
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87871239
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87439719
103Dorso-ventral axis formation_Homo sapiens_hsa043200.86590241
104mRNA surveillance pathway_Homo sapiens_hsa030150.86399200
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85131123
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84794427
107FoxO signaling pathway_Homo sapiens_hsa040680.84780646
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84746566
109Gastric acid secretion_Homo sapiens_hsa049710.83487726
110Linoleic acid metabolism_Homo sapiens_hsa005910.82900249
111Thyroid hormone synthesis_Homo sapiens_hsa049180.82674194
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81957529
113Oxytocin signaling pathway_Homo sapiens_hsa049210.81673177
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80878314
115Purine metabolism_Homo sapiens_hsa002300.80290722
116Ras signaling pathway_Homo sapiens_hsa040140.78607377
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76918812
118beta-Alanine metabolism_Homo sapiens_hsa004100.76740891
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76548500
120Chronic myeloid leukemia_Homo sapiens_hsa052200.74339673
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74078125
122Insulin signaling pathway_Homo sapiens_hsa049100.73722436
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71847959
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71704700
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69899811
126Melanoma_Homo sapiens_hsa052180.69656274
127Viral myocarditis_Homo sapiens_hsa054160.69446561
128Metabolic pathways_Homo sapiens_hsa011000.69347361
129Steroid biosynthesis_Homo sapiens_hsa001000.68432888
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68391602
131Pyruvate metabolism_Homo sapiens_hsa006200.66844366
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66604263
133Fatty acid metabolism_Homo sapiens_hsa012120.66057435
134MAPK signaling pathway_Homo sapiens_hsa040100.64887383
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64727178
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63575033
137Glucagon signaling pathway_Homo sapiens_hsa049220.63232435
138Retinol metabolism_Homo sapiens_hsa008300.63052851
139Non-small cell lung cancer_Homo sapiens_hsa052230.62528799
140Fatty acid degradation_Homo sapiens_hsa000710.62266173
141Basal cell carcinoma_Homo sapiens_hsa052170.61857770
142cAMP signaling pathway_Homo sapiens_hsa040240.61774808
143TGF-beta signaling pathway_Homo sapiens_hsa043500.61537329
144AMPK signaling pathway_Homo sapiens_hsa041520.60825995
145Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60679742
146Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60394682
147Hedgehog signaling pathway_Homo sapiens_hsa043400.59961546
148Salivary secretion_Homo sapiens_hsa049700.59549964
149Sphingolipid metabolism_Homo sapiens_hsa006000.59139083
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58948144
151alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57879317
152Proteoglycans in cancer_Homo sapiens_hsa052050.56307483
153Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56123856
154Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55653726
155Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55059427
156Insulin resistance_Homo sapiens_hsa049310.54965137
157Cardiac muscle contraction_Homo sapiens_hsa042600.54694994
158Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54572600
159Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53531973
160Steroid hormone biosynthesis_Homo sapiens_hsa001400.52972446
161Chemical carcinogenesis_Homo sapiens_hsa052040.52761773
162Mineral absorption_Homo sapiens_hsa049780.52300787
163Glutathione metabolism_Homo sapiens_hsa004800.49391042
164Pyrimidine metabolism_Homo sapiens_hsa002400.49264657
165Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46340483
166p53 signaling pathway_Homo sapiens_hsa041150.44375345
167Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37264553

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