LIN9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore organization (GO:0051383)4.57745453
2telomere maintenance via semi-conservative replication (GO:0032201)4.31976406
3DNA replication initiation (GO:0006270)4.26600030
4CENP-A containing nucleosome assembly (GO:0034080)4.21564309
5DNA strand elongation involved in DNA replication (GO:0006271)4.17742529
6telomere maintenance via recombination (GO:0000722)4.14650903
7nuclear pore complex assembly (GO:0051292)4.12652555
8chromatin remodeling at centromere (GO:0031055)4.12235487
9mitotic recombination (GO:0006312)4.09700506
10DNA strand elongation (GO:0022616)4.09673073
11kinetochore assembly (GO:0051382)4.08965223
12meiotic chromosome segregation (GO:0045132)3.98666949
13nuclear pore organization (GO:0006999)3.97470166
14establishment of integrated proviral latency (GO:0075713)3.95296174
15DNA replication checkpoint (GO:0000076)3.92071413
16protein localization to kinetochore (GO:0034501)3.82725959
17mitotic metaphase plate congression (GO:0007080)3.79924660
18telomere maintenance via telomere lengthening (GO:0010833)3.66082717
19DNA replication-independent nucleosome assembly (GO:0006336)3.66029251
20DNA replication-independent nucleosome organization (GO:0034724)3.66029251
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.64595224
22DNA unwinding involved in DNA replication (GO:0006268)3.63284556
23protein K6-linked ubiquitination (GO:0085020)3.60004084
24negative regulation of DNA-dependent DNA replication (GO:2000104)3.55850002
25metaphase plate congression (GO:0051310)3.55813402
26protein localization to chromosome, centromeric region (GO:0071459)3.53120016
27regulation of DNA endoreduplication (GO:0032875)3.51394458
28mitotic sister chromatid cohesion (GO:0007064)3.49344335
29nucleotide-excision repair, DNA gap filling (GO:0006297)3.47923892
30regulation of mitotic spindle organization (GO:0060236)3.44492904
31histone exchange (GO:0043486)3.42885799
32pore complex assembly (GO:0046931)3.42043635
33mitotic sister chromatid segregation (GO:0000070)3.41200087
34regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.40967752
35positive regulation of chromosome segregation (GO:0051984)3.40914806
36regulation of nuclear cell cycle DNA replication (GO:0033262)3.37282073
37establishment of chromosome localization (GO:0051303)3.36535875
38chromosome condensation (GO:0030261)3.34127848
39sister chromatid segregation (GO:0000819)3.33045814
40DNA synthesis involved in DNA repair (GO:0000731)3.29403403
41attachment of spindle microtubules to kinetochore (GO:0008608)3.29167998
42mitotic chromosome condensation (GO:0007076)3.28833970
43double-strand break repair via nonhomologous end joining (GO:0006303)3.27048410
44non-recombinational repair (GO:0000726)3.27048410
45telomere maintenance (GO:0000723)3.24772733
46maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.24339888
47ribosome assembly (GO:0042255)3.23055308
48telomere organization (GO:0032200)3.21747661
49regulation of sister chromatid cohesion (GO:0007063)3.19457868
50ribosomal small subunit assembly (GO:0000028)3.18287361
51regulation of spindle organization (GO:0090224)3.13229260
52regulation of double-strand break repair via homologous recombination (GO:0010569)3.11871825
53spindle checkpoint (GO:0031577)3.09638969
54replication fork processing (GO:0031297)3.07815275
55mitotic nuclear envelope disassembly (GO:0007077)3.07804429
56DNA packaging (GO:0006323)3.05588202
57DNA topological change (GO:0006265)3.04865290
58* mitotic cell cycle (GO:0000278)3.03612978
59somatic hypermutation of immunoglobulin genes (GO:0016446)3.03611144
60somatic diversification of immune receptors via somatic mutation (GO:0002566)3.03611144
61mitotic G2/M transition checkpoint (GO:0044818)3.03561342
62mismatch repair (GO:0006298)3.02456030
63IMP metabolic process (GO:0046040)3.02121805
64anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01390077
65negative regulation of mitosis (GO:0045839)3.00458399
66centriole replication (GO:0007099)2.99994121
67regulation of centriole replication (GO:0046599)2.99707092
68regulation of mitotic spindle checkpoint (GO:1903504)2.99199189
69regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.99199189
70regulation of mitotic metaphase/anaphase transition (GO:0030071)2.97982730
71microtubule depolymerization (GO:0007019)2.97624649
72spindle assembly checkpoint (GO:0071173)2.97440254
73positive regulation of DNA-dependent DNA replication (GO:2000105)2.93968569
74chromosome segregation (GO:0007059)2.93924010
75resolution of meiotic recombination intermediates (GO:0000712)2.93887910
76DNA catabolic process, exonucleolytic (GO:0000738)2.93570741
77mitochondrial RNA metabolic process (GO:0000959)2.93561832
78negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.93533581
79negative regulation of sister chromatid segregation (GO:0033046)2.93533581
80negative regulation of mitotic sister chromatid separation (GO:2000816)2.93533581
81negative regulation of mitotic sister chromatid segregation (GO:0033048)2.93533581
82negative regulation of chromosome segregation (GO:0051985)2.92586335
83DNA ligation (GO:0006266)2.91481132
84regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91026223
85regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.90548359
86DNA geometric change (GO:0032392)2.90251610
87DNA duplex unwinding (GO:0032508)2.87817238
88DNA double-strand break processing (GO:0000729)2.87135655
89mitotic spindle assembly checkpoint (GO:0007094)2.85448312
90negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84661900
91regulation of mitotic sister chromatid separation (GO:0010965)2.84518990
92regulation of mitotic sister chromatid segregation (GO:0033047)2.84518990
93regulation of sister chromatid segregation (GO:0033045)2.84518990
94intra-S DNA damage checkpoint (GO:0031573)2.83785783
95mitotic spindle checkpoint (GO:0071174)2.81974504
96regulation of centrosome cycle (GO:0046605)2.81181543
97DNA strand renaturation (GO:0000733)2.81173766
98ATP-dependent chromatin remodeling (GO:0043044)2.79620671
99regulation of chromosome segregation (GO:0051983)2.78712469
100protein localization to chromosome (GO:0034502)2.78657898
101IMP biosynthetic process (GO:0006188)2.78052188
102regulation of DNA-dependent DNA replication (GO:0090329)2.77959034
103sister chromatid cohesion (GO:0007062)2.77599761
104nuclear envelope disassembly (GO:0051081)2.77041427
105membrane disassembly (GO:0030397)2.77041427
106translesion synthesis (GO:0019985)2.76103060
107chromatin assembly or disassembly (GO:0006333)2.73928442
108positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.72694601
109positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.72694601
110positive regulation of mitotic sister chromatid separation (GO:1901970)2.72694601
111DNA replication (GO:0006260)2.70017970
112DNA replication-dependent nucleosome assembly (GO:0006335)2.69586288
113DNA replication-dependent nucleosome organization (GO:0034723)2.69586288
114DNA-dependent DNA replication (GO:0006261)2.68855488
115reciprocal DNA recombination (GO:0035825)2.67719911
116reciprocal meiotic recombination (GO:0007131)2.67719911
117transcription-coupled nucleotide-excision repair (GO:0006283)2.66435554
118RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.66114558
119regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.65871962
120purine nucleobase biosynthetic process (GO:0009113)2.65292528
121ribosome biogenesis (GO:0042254)2.64001229
122DNA conformation change (GO:0071103)2.63841754
123nucleobase biosynthetic process (GO:0046112)2.63618803

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.92955122
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.57013147
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.66172540
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.29772635
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.76941274
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.54530756
7* E2F1_21310950_ChIP-Seq_MCF-7_Human2.36748445
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.31205850
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31093321
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30833754
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.30374966
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.27031393
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.25025223
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17475341
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.16006625
16VDR_23849224_ChIP-Seq_CD4+_Human2.13467688
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12442845
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.11410000
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.11137008
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.08263031
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.08017621
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04087107
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03020085
24ELK1_19687146_ChIP-ChIP_HELA_Human2.00825254
25E2F7_22180533_ChIP-Seq_HELA_Human10.7218983
26AR_21909140_ChIP-Seq_LNCAP_Human1.95001085
27FOXP3_21729870_ChIP-Seq_TREG_Human1.92652011
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88865658
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88181565
30* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85557491
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84847535
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.83680881
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81860729
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81410336
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.80326888
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77200591
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69879997
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68919755
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62382000
40XRN2_22483619_ChIP-Seq_HELA_Human1.61777920
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60453316
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.59784929
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.59641737
44* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54938281
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.54322997
46DCP1A_22483619_ChIP-Seq_HELA_Human1.50039480
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49900400
48* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49744303
49CIITA_25753668_ChIP-Seq_RAJI_Human1.47749774
50* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47651913
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47625944
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42879618
53* TTF2_22483619_ChIP-Seq_HELA_Human1.42766480
54GABP_19822575_ChIP-Seq_HepG2_Human1.40496512
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40490736
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38467602
57* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37639132
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.36259008
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33740565
60SPI1_23547873_ChIP-Seq_NB4_Human1.33677196
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32305835
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32070333
63FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30250789
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27766194
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24428814
66FUS_26573619_Chip-Seq_HEK293_Human1.20657969
67IRF8_22096565_ChIP-ChIP_GC-B_Human1.20400477
68MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.16601932
69* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13896626
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.11948732
71MYC_22102868_ChIP-Seq_BL_Human1.10569242
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10364894
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09820274
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.07308697
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.07238619
76* KDM5A_27292631_Chip-Seq_BREAST_Human1.06651118
77* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06209454
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04773722
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01445591
80MYC_18940864_ChIP-ChIP_HL60_Human0.98993071
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98213446
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97787212
83SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97622066
84SCL_19346495_ChIP-Seq_HPC-7_Human0.96494108
85SOX17_20123909_ChIP-Seq_XEN_Mouse0.95518589
86MYB_26560356_Chip-Seq_TH2_Human0.93480375
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91791630
88MYB_26560356_Chip-Seq_TH1_Human0.89840526
89STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.88831723
90HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86730384
91ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85902217
92FLI1_27457419_Chip-Seq_LIVER_Mouse0.85475883
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83511371
94TAF15_26573619_Chip-Seq_HEK293_Human0.83159832
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81988725
96MYB_21317192_ChIP-Seq_ERMYB_Mouse0.81050360
97IRF1_19129219_ChIP-ChIP_H3396_Human0.80142241
98POU5F1_16153702_ChIP-ChIP_HESCs_Human0.79515080
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.79425876
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79156084
101STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.78359478
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77570949
103CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77393474
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77392747
105RUNX1_22412390_ChIP-Seq_EML_Mouse0.77376725
106TFEB_21752829_ChIP-Seq_HELA_Human0.76721574
107PCGF2_27294783_Chip-Seq_ESCs_Mouse0.76618238
108VDR_22108803_ChIP-Seq_LS180_Human0.76328582
109POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76159243
110* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.75748208
111CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.74785884
112EWS_26573619_Chip-Seq_HEK293_Human0.74392171
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.73749477
114KLF4_18555785_ChIP-Seq_MESCs_Mouse0.72821328
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.72411185
116PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.72178060
117* CHD1_26751641_Chip-Seq_LNCaP_Human0.71266878
118SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.70621208
119E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.69760853
120KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.67546405
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.66362939
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.64996301
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.62608571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.41270476
2MP0003693_abnormal_embryo_hatching4.19760305
3MP0003111_abnormal_nucleus_morphology3.87825576
4MP0008057_abnormal_DNA_replication3.77523854
5MP0008058_abnormal_DNA_repair3.48135801
6MP0003077_abnormal_cell_cycle3.29765630
7MP0008007_abnormal_cellular_replicative3.01753270
8MP0004957_abnormal_blastocyst_morpholog2.85661593
9MP0002396_abnormal_hematopoietic_system2.74591603
10MP0006292_abnormal_olfactory_placode2.32243148
11MP0008877_abnormal_DNA_methylation2.28430557
12MP0003786_premature_aging2.16698675
13MP0001835_abnormal_antigen_presentation2.01746272
14MP0010307_abnormal_tumor_latency1.94384953
15MP0000490_abnormal_crypts_of1.93889074
16MP0004808_abnormal_hematopoietic_stem1.81547446
17MP0000372_irregular_coat_pigmentation1.80723013
18* MP0008932_abnormal_embryonic_tissue1.76487959
19MP0003763_abnormal_thymus_physiology1.74661635
20MP0003136_yellow_coat_color1.66791033
21MP0000350_abnormal_cell_proliferation1.55841267
22MP0005671_abnormal_response_to1.54197231
23MP0002398_abnormal_bone_marrow1.50100320
24MP0003937_abnormal_limbs/digits/tail_de1.49259885
25MP0000015_abnormal_ear_pigmentation1.49085285
26MP0005397_hematopoietic_system_phenotyp1.47824300
27MP0001545_abnormal_hematopoietic_system1.47824300
28MP0009333_abnormal_splenocyte_physiolog1.42073459
29MP0001529_abnormal_vocalization1.41765726
30MP0002084_abnormal_developmental_patter1.41507886
31MP0002009_preneoplasia1.40069021
32MP0002210_abnormal_sex_determination1.38261398
33MP0003123_paternal_imprinting1.36710555
34MP0010352_gastrointestinal_tract_polyps1.36652933
35MP0000703_abnormal_thymus_morphology1.33049301
36MP0006072_abnormal_retinal_apoptosis1.31539928
37MP0001800_abnormal_humoral_immune1.29443120
38MP0002095_abnormal_skin_pigmentation1.29227035
39MP0000313_abnormal_cell_death1.28693516
40MP0008789_abnormal_olfactory_epithelium1.28301167
41MP0006035_abnormal_mitochondrial_morpho1.27850924
42MP0001188_hyperpigmentation1.27431044
43MP0000689_abnormal_spleen_morphology1.26750550
44MP0002019_abnormal_tumor_incidence1.26664946
45MP0005174_abnormal_tail_pigmentation1.26385294
46MP0002234_abnormal_pharynx_morphology1.24561408
47MP0002722_abnormal_immune_system1.23926474
48MP0002452_abnormal_antigen_presenting1.23679158
49MP0009785_altered_susceptibility_to1.21177037
50MP0002420_abnormal_adaptive_immunity1.19254481
51MP0001119_abnormal_female_reproductive1.19254088
52MP0001730_embryonic_growth_arrest1.18947024
53MP0003121_genomic_imprinting1.18046849
54MP0001819_abnormal_immune_cell1.17979725
55MP0005187_abnormal_penis_morphology1.15623139
56MP0003941_abnormal_skin_development1.15237915
57MP0005380_embryogenesis_phenotype1.15132739
58MP0001672_abnormal_embryogenesis/_devel1.15132739
59MP0000566_synostosis1.13155632
60MP0000716_abnormal_immune_system1.12696171
61MP0003718_maternal_effect1.11708932
62MP0003890_abnormal_embryonic-extraembry1.10517349
63MP0002723_abnormal_immune_serum1.10329326
64MP0002429_abnormal_blood_cell1.10141280
65MP0009672_abnormal_birth_weight1.08251022
66MP0001145_abnormal_male_reproductive1.07784476
67MP0002697_abnormal_eye_size1.05492625
68MP0001929_abnormal_gametogenesis1.04984090
69MP0001286_abnormal_eye_development1.04576186
70MP0010030_abnormal_orbit_morphology1.04341131
71MP0005075_abnormal_melanosome_morpholog1.03946256
72MP0002877_abnormal_melanocyte_morpholog1.03745061
73MP0006036_abnormal_mitochondrial_physio1.02792269
74MP0003315_abnormal_perineum_morphology1.02359343
75MP0002092_abnormal_eye_morphology1.02143673
76MP0003436_decreased_susceptibility_to1.01875225
77MP0002233_abnormal_nose_morphology1.01443536
78MP0005000_abnormal_immune_tolerance1.00952607
79MP0001697_abnormal_embryo_size1.00712743
80MP0000685_abnormal_immune_system0.99384272
81MP0003984_embryonic_growth_retardation0.99306577
82MP0001346_abnormal_lacrimal_gland0.98483370
83MP0002148_abnormal_hypersensitivity_rea0.97522845
84MP0002405_respiratory_system_inflammati0.97448484
85MP0000858_altered_metastatic_potential0.96529756
86MP0003943_abnormal_hepatobiliary_system0.96264950
87MP0005389_reproductive_system_phenotype0.95943283
88MP0002088_abnormal_embryonic_growth/wei0.95643072
89MP0005025_abnormal_response_to0.95572573
90MP0000653_abnormal_sex_gland0.94720323
91MP0005387_immune_system_phenotype0.94395266
92MP0001790_abnormal_immune_system0.94395266
93MP0002938_white_spotting0.94083773
94MP0002160_abnormal_reproductive_system0.93834279
95MP0000647_abnormal_sebaceous_gland0.93832324
96MP0002419_abnormal_innate_immunity0.93190332
97MP0002102_abnormal_ear_morphology0.92532616
98MP0004147_increased_porphyrin_level0.91683230
99MP0000358_abnormal_cell_content/0.91002982
100MP0001853_heart_inflammation0.90769758
101MP0003787_abnormal_imprinting0.89942157
102MP0005076_abnormal_cell_differentiation0.89925411
103* MP0002086_abnormal_extraembryonic_tissu0.89738503
104* MP0002080_prenatal_lethality0.89392707
105MP0003567_abnormal_fetal_cardiomyocyte0.88792797
106MP0010155_abnormal_intestine_physiology0.88567993
107* MP0002085_abnormal_embryonic_tissue0.87785994
108MP0004197_abnormal_fetal_growth/weight/0.87310251
109MP0009697_abnormal_copulation0.87262363
110MP0003186_abnormal_redox_activity0.87239666
111MP0004215_abnormal_myocardial_fiber0.87099382
112MP0008995_early_reproductive_senescence0.87073650
113MP0002132_abnormal_respiratory_system0.86761787
114MP0001919_abnormal_reproductive_system0.86586899
115MP0002163_abnormal_gland_morphology0.85404775
116MP0003385_abnormal_body_wall0.85334123
117MP0002006_tumorigenesis0.85064768
118MP0000569_abnormal_digit_pigmentation0.84977747
119MP0005367_renal/urinary_system_phenotyp0.84565876
120MP0000516_abnormal_urinary_system0.84565876
121MP0005391_vision/eye_phenotype0.84479658
122MP0003119_abnormal_digestive_system0.83919723
123MP0009703_decreased_birth_body0.83832502
124MP0002111_abnormal_tail_morphology0.83654812
125MP0005499_abnormal_olfactory_system0.83561547
126MP0005394_taste/olfaction_phenotype0.83561547
127MP0001293_anophthalmia0.83492093
128MP0009278_abnormal_bone_marrow0.81996377
129MP0000537_abnormal_urethra_morphology0.81532795
130MP0001873_stomach_inflammation0.78565971
131MP0003221_abnormal_cardiomyocyte_apopto0.78462652
132MP0003755_abnormal_palate_morphology0.77766943
133MP0001186_pigmentation_phenotype0.76964122
134MP0002075_abnormal_coat/hair_pigmentati0.76836555
135MP0003861_abnormal_nervous_system0.76383462
136MP0005464_abnormal_platelet_physiology0.76234988
137MP0003698_abnormal_male_reproductive0.73077181
138MP0003935_abnormal_craniofacial_develop0.69313848
139MP0003806_abnormal_nucleotide_metabolis0.68291621
140MP0003699_abnormal_female_reproductive0.67120552
141MP0000428_abnormal_craniofacial_morphol0.63624008
142MP0001661_extended_life_span0.63292282
143MP0002751_abnormal_autonomic_nervous0.62647378
144MP0004084_abnormal_cardiac_muscle0.62622364
145MP0002090_abnormal_vision0.62229583
146MP0000631_abnormal_neuroendocrine_gland0.62218517
147MP0002161_abnormal_fertility/fecundity0.61746524
148MP0005395_other_phenotype0.60997829
149MP0000432_abnormal_head_morphology0.60120048
150MP0005253_abnormal_eye_physiology0.59924456
151MP0000049_abnormal_middle_ear0.59775562

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.37338115
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.31214680
3Birth length less than 3rd percentile (HP:0003561)3.94835833
4Abnormality of chromosome stability (HP:0003220)3.89100580
5Meckel diverticulum (HP:0002245)3.71161773
6Abnormality of the preputium (HP:0100587)3.60897919
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.58117556
8Abnormality of the ileum (HP:0001549)3.49995282
9Myelodysplasia (HP:0002863)3.04911455
10Clubbing of toes (HP:0100760)3.01663802
11Ectopic kidney (HP:0000086)2.94779182
12Reticulocytopenia (HP:0001896)2.93363821
13Small intestinal stenosis (HP:0012848)2.89720249
14Duodenal stenosis (HP:0100867)2.89720249
15Abnormality of the labia minora (HP:0012880)2.83691986
16Bone marrow hypocellularity (HP:0005528)2.79317850
17Aplastic anemia (HP:0001915)2.71988627
18Patellar aplasia (HP:0006443)2.68670632
19Cortical dysplasia (HP:0002539)2.57949933
20Impulsivity (HP:0100710)2.56377002
2111 pairs of ribs (HP:0000878)2.56107321
22Absent thumb (HP:0009777)2.55596957
23Abnormality of the carotid arteries (HP:0005344)2.55427363
24Volvulus (HP:0002580)2.49221369
25Aplasia/Hypoplasia of the patella (HP:0006498)2.48434411
26Abnormality of DNA repair (HP:0003254)2.46108632
27Increased serum pyruvate (HP:0003542)2.46005910
28Multiple enchondromatosis (HP:0005701)2.45037876
29Duplicated collecting system (HP:0000081)2.44655726
30Sloping forehead (HP:0000340)2.42635806
31Abnormality of glycolysis (HP:0004366)2.42361287
32Rhabdomyosarcoma (HP:0002859)2.41632213
33IgM deficiency (HP:0002850)2.40317574
34IgG deficiency (HP:0004315)2.37996101
35Nephroblastoma (Wilms tumor) (HP:0002667)2.36934849
36Abnormality of the fingertips (HP:0001211)2.35858023
37Abnormality of the duodenum (HP:0002246)2.35451592
38Agnosia (HP:0010524)2.34822780
39Abnormality of the renal collecting system (HP:0004742)2.33387818
40Medulloblastoma (HP:0002885)2.31710542
41Oral leukoplakia (HP:0002745)2.30508393
42Increased hepatocellular lipid droplets (HP:0006565)2.28688780
43Acute necrotizing encephalopathy (HP:0006965)2.27722480
44Colon cancer (HP:0003003)2.26812533
45Premature graying of hair (HP:0002216)2.26781336
46Amaurosis fugax (HP:0100576)2.25096060
47Abnormal lung lobation (HP:0002101)2.24816107
48Acute encephalopathy (HP:0006846)2.24459821
49Embryonal renal neoplasm (HP:0011794)2.23519505
50Aplasia/Hypoplasia of the sternum (HP:0006714)2.20971836
51Selective tooth agenesis (HP:0001592)2.19327646
52Prostate neoplasm (HP:0100787)2.19079375
53Abnormality of the prostate (HP:0008775)2.18360158
54Breast hypoplasia (HP:0003187)2.16362254
55Facial cleft (HP:0002006)2.15878537
56Abnormal mitochondria in muscle tissue (HP:0008316)2.15263203
57Triphalangeal thumb (HP:0001199)2.13837965
58Lymphoma (HP:0002665)2.12371488
59Thrombocytosis (HP:0001894)2.11142638
60Optic nerve coloboma (HP:0000588)2.10794506
61Supernumerary spleens (HP:0009799)2.10660153
62Abnormality of cochlea (HP:0000375)2.08552372
63Hypoplasia of the pons (HP:0012110)2.07877847
64Ependymoma (HP:0002888)2.05813472
65Neoplasm of the colon (HP:0100273)2.05634028
66Type 2 muscle fiber atrophy (HP:0003554)2.05289241
67Tracheoesophageal fistula (HP:0002575)2.05289095
68Horseshoe kidney (HP:0000085)2.04925565
69Lipid accumulation in hepatocytes (HP:0006561)2.04682879
70Choanal atresia (HP:0000453)2.04324472
71Type I transferrin isoform profile (HP:0003642)2.03434829
72Abnormality of the pons (HP:0007361)2.02605876
73Abnormal spermatogenesis (HP:0008669)2.01710644
74Short thumb (HP:0009778)1.99440600
75Recurrent abscess formation (HP:0002722)1.97917257
76Absent radius (HP:0003974)1.95136326
77Abnormality of methionine metabolism (HP:0010901)1.94857050
78Glioma (HP:0009733)1.94771259
79Increased CSF lactate (HP:0002490)1.93366030
80Rough bone trabeculation (HP:0100670)1.91756092
81Muscle fiber atrophy (HP:0100295)1.90705250
82Septate vagina (HP:0001153)1.89420834
83Aplasia/Hypoplasia of the sacrum (HP:0008517)1.88700373
84Acute myeloid leukemia (HP:0004808)1.85283184
85Aplasia involving forearm bones (HP:0009822)1.85029609
86Absent forearm bone (HP:0003953)1.85029609
87Pancytopenia (HP:0001876)1.84718791
88Cerebral edema (HP:0002181)1.84133848
89Cellular immunodeficiency (HP:0005374)1.82403261
90Increased nuchal translucency (HP:0010880)1.82053752
91Mediastinal lymphadenopathy (HP:0100721)1.81543369
92Abnormality of the anterior horn cell (HP:0006802)1.79947279
93Degeneration of anterior horn cells (HP:0002398)1.79947279
94Spinal cord lesions (HP:0100561)1.79373836
95Syringomyelia (HP:0003396)1.79373836
96Abnormality of chromosome segregation (HP:0002916)1.78636991
97Embryonal neoplasm (HP:0002898)1.77422022
98Proximal placement of thumb (HP:0009623)1.77236849
99Myositis (HP:0100614)1.76493693
100Optic neuritis (HP:0100653)1.76237012
101Retrobulbar optic neuritis (HP:0100654)1.76237012
102Abnormality of T cell physiology (HP:0011840)1.76093596
103Overlapping toe (HP:0001845)1.75067543
104Leukopenia (HP:0001882)1.74260042
105Pulmonary fibrosis (HP:0002206)1.74224710
106Neoplasm of the pancreas (HP:0002894)1.72851061
107Microvesicular hepatic steatosis (HP:0001414)1.72683854
108Progressive macrocephaly (HP:0004481)1.71557094
109IgA deficiency (HP:0002720)1.71192255
110Astrocytoma (HP:0009592)1.70734344
111Abnormality of the astrocytes (HP:0100707)1.70734344
112Homocystinuria (HP:0002156)1.70708324
113Abnormality of homocysteine metabolism (HP:0010919)1.70708324
114Increased serum lactate (HP:0002151)1.70450048
115Mitochondrial inheritance (HP:0001427)1.70163458
116Abnormal number of incisors (HP:0011064)1.67944339
117Megaloblastic anemia (HP:0001889)1.66765145
118Morphological abnormality of the inner ear (HP:0011390)1.66741364
119Abnormal umbilical cord blood vessels (HP:0011403)1.66370707
120Single umbilical artery (HP:0001195)1.66370707
121Abnormality of the fetal cardiovascular system (HP:0010948)1.66370707
122Abnormality of T cells (HP:0002843)1.65333709
123Pallor (HP:0000980)1.63890199
124Long clavicles (HP:0000890)1.63875634
125Squamous cell carcinoma (HP:0002860)1.63709927
126Ovarian neoplasm (HP:0100615)1.63518903
127Recurrent viral infections (HP:0004429)1.63257346
128Short middle phalanx of the 5th finger (HP:0004220)1.63243546
129Entropion (HP:0000621)1.62004225
130Pancreatic fibrosis (HP:0100732)1.61198426
131Premature ovarian failure (HP:0008209)1.60213447
132Prominent metopic ridge (HP:0005487)1.59661205
133Chronic obstructive pulmonary disease (HP:0006510)1.59374937
134Obstructive lung disease (HP:0006536)1.59374937
135True hermaphroditism (HP:0010459)1.59300368
136Hepatic necrosis (HP:0002605)1.58148278
137Hypoplasia of the capital femoral epiphysis (HP:0003090)1.57969866
138Prominent nose (HP:0000448)1.57961576
139Cleft eyelid (HP:0000625)1.57467375
140Hepatocellular necrosis (HP:0001404)1.57004075
141Pancreatic cysts (HP:0001737)1.56759345
142Hypoplastic pelvis (HP:0008839)1.56336282
143Abnormality of aspartate family amino acid metabolism (HP:0010899)1.56241047
144Postnatal microcephaly (HP:0005484)1.56102349
145Carpal bone hypoplasia (HP:0001498)1.56046791
146Deep philtrum (HP:0002002)1.56040945
147Deviation of the thumb (HP:0009603)1.55944916
148Atresia of the external auditory canal (HP:0000413)1.55863332
149Reduced antithrombin III activity (HP:0001976)1.55555361
150Arteriovenous malformation (HP:0100026)1.55535318
151Abnormality of the metopic suture (HP:0005556)1.55364293
152Meningitis (HP:0001287)1.55023774
153Abnormality of serum amino acid levels (HP:0003112)1.54357293
154Abnormal number of erythroid precursors (HP:0012131)1.54274800
155Cafe-au-lait spot (HP:0000957)1.54094613
156Secondary amenorrhea (HP:0000869)1.52660911

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.84812470
2PLK43.13173381
3WEE13.02621279
4PBK2.98698242
5BUB12.97861248
6SRPK12.89475441
7ZAK2.70773973
8NEK22.52915084
9EIF2AK12.39730776
10MKNK12.39402640
11MKNK22.28007306
12MST42.20787419
13BRSK22.18655748
14ACVR1B2.11597152
15TTK2.05764263
16STK162.03732326
17VRK21.96868264
18TXK1.87917409
19PLK11.86939748
20ATR1.86213206
21VRK11.85598899
22IRAK41.83125580
23AURKB1.66035687
24CCNB11.62972619
25EIF2AK31.62415347
26IRAK31.54789027
27TLK11.46921631
28CHEK21.46090547
29PLK31.44358001
30YES11.43351058
31EIF2AK21.42653200
32STK41.41972698
33TRIM281.40843910
34RPS6KA41.40668498
35CDK71.40158786
36BRD41.37856500
37CLK11.36828056
38PNCK1.35381821
39TAF11.31858357
40TSSK61.31382749
41PASK1.30636003
42CDK121.29862224
43PIM11.29773394
44TEC1.27722783
45NME21.27124881
46MAP3K141.24726309
47DYRK31.24697568
48BRSK11.24325084
49STK31.15644030
50MAP4K11.15097459
51STK101.09837482
52JAK31.09468871
53CDK41.02992641
54CHEK11.01035177
55TGFBR10.99424838
56CDK80.99382936
57ATM0.99093905
58BTK0.94585124
59KIT0.86237267
60NUAK10.85549298
61RPS6KB20.85086402
62NEK10.83646916
63CHUK0.82742276
64WNK30.80086503
65BRAF0.77581230
66CDK60.76934677
67NME10.75743628
68IKBKB0.73288767
69AURKA0.71906220
70TNIK0.71881222
71MELK0.70028085
72CDK20.68946109
73STK38L0.67344698
74MAP3K80.66068253
75TAOK20.66022591
76NLK0.65741290
77SCYL20.65698830
78PDK20.64835003
79MAP2K30.64342603
80ALK0.63399631
81PIM20.62543792
82TRPM70.62460756
83MAP3K100.61315812
84AKT30.60201979
85ERBB30.59817785
86RPS6KA50.59297443
87CDK10.57118831
88STK240.57105571
89LYN0.55496672
90CSNK2A10.55346295
91BCR0.55318185
92PLK20.54673192
93BMPR1B0.54018573
94IKBKE0.53931549
95MAP4K20.52968726
96MARK30.51442404
97CDK90.50732591
98CSNK1E0.49199022
99ERBB40.47854615
100ZAP700.46514977
101TYK20.46282547
102EPHA20.45713750
103RAF10.45153880
104CSNK2A20.41985798
105NEK90.41144128
106FLT30.39895372
107CSF1R0.39209996
108EEF2K0.39041982
109MUSK0.38907244
110PRKDC0.38842649
111AKT20.38715527
112DMPK0.38397383
113MAP3K40.38286684
114IRAK10.38184426
115TESK20.37735605
116CSNK1G10.37700166
117LATS10.37226617
118LCK0.35936015
119MET0.34034590
120MST1R0.33750251
121SGK20.33456990
122RPS6KA60.32449278
123RPS6KC10.31822116
124RPS6KL10.31822116
125SYK0.31317824
126* CDK30.30683784
127CDK180.30471867
128AKT10.30139283
129PAK40.29893083
130MAPK140.29803416
131CSK0.29764370
132CDK150.26785180
133CDK11A0.25378806
134FGFR10.24722274
135CDK140.24506482
136CSNK1G30.24411071
137STK390.23079053
138PRKCI0.22131526
139PKN10.21042635
140NEK60.20842828

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.58116653
2Mismatch repair_Homo sapiens_hsa034303.84556626
3Homologous recombination_Homo sapiens_hsa034403.40214455
4Base excision repair_Homo sapiens_hsa034103.17106210
5Fanconi anemia pathway_Homo sapiens_hsa034603.03292909
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97961612
7Cell cycle_Homo sapiens_hsa041102.74378891
8Nucleotide excision repair_Homo sapiens_hsa034202.72688430
9Spliceosome_Homo sapiens_hsa030402.60125218
10Non-homologous end-joining_Homo sapiens_hsa034502.36110554
11RNA transport_Homo sapiens_hsa030132.27799979
12RNA polymerase_Homo sapiens_hsa030202.24399879
13One carbon pool by folate_Homo sapiens_hsa006702.21969303
14Basal transcription factors_Homo sapiens_hsa030222.12028072
15RNA degradation_Homo sapiens_hsa030182.05062771
16Pyrimidine metabolism_Homo sapiens_hsa002402.01289223
17Ribosome_Homo sapiens_hsa030101.79373273
18Proteasome_Homo sapiens_hsa030501.76006773
19p53 signaling pathway_Homo sapiens_hsa041151.75224214
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74199792
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61622874
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.58941548
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.58318339
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.55415108
25Herpes simplex infection_Homo sapiens_hsa051681.49801571
26Pyruvate metabolism_Homo sapiens_hsa006201.49673004
27Primary immunodeficiency_Homo sapiens_hsa053401.49447523
28Systemic lupus erythematosus_Homo sapiens_hsa053221.45467767
29mRNA surveillance pathway_Homo sapiens_hsa030151.44706378
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44134877
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.42059331
32Parkinsons disease_Homo sapiens_hsa050121.37877600
33Oxidative phosphorylation_Homo sapiens_hsa001901.37700117
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.35455454
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30324056
36Propanoate metabolism_Homo sapiens_hsa006401.28133706
37Purine metabolism_Homo sapiens_hsa002301.22973855
38Measles_Homo sapiens_hsa051621.22640205
39Antigen processing and presentation_Homo sapiens_hsa046121.18608247
40Huntingtons disease_Homo sapiens_hsa050161.17342432
41Allograft rejection_Homo sapiens_hsa053301.17166578
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14929998
43Steroid biosynthesis_Homo sapiens_hsa001001.14273433
44Epstein-Barr virus infection_Homo sapiens_hsa051691.13422440
45Biosynthesis of amino acids_Homo sapiens_hsa012301.07298536
46Viral carcinogenesis_Homo sapiens_hsa052031.01704900
47Carbon metabolism_Homo sapiens_hsa012001.00484018
48NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97199301
49Autoimmune thyroid disease_Homo sapiens_hsa053200.97009751
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95896103
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94786280
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94075605
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93916311
54HTLV-I infection_Homo sapiens_hsa051660.93348564
55Hematopoietic cell lineage_Homo sapiens_hsa046400.91334146
56Leishmaniasis_Homo sapiens_hsa051400.87312250
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86695914
58Legionellosis_Homo sapiens_hsa051340.86395922
59Asthma_Homo sapiens_hsa053100.86374149
60Influenza A_Homo sapiens_hsa051640.81850560
61Folate biosynthesis_Homo sapiens_hsa007900.78441733
62Hepatitis B_Homo sapiens_hsa051610.77708466
63Fatty acid elongation_Homo sapiens_hsa000620.77331265
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75634638
65Small cell lung cancer_Homo sapiens_hsa052220.72811206
66Alzheimers disease_Homo sapiens_hsa050100.72467247
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71748244
68Apoptosis_Homo sapiens_hsa042100.70822741
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70024928
70MicroRNAs in cancer_Homo sapiens_hsa052060.69701725
71Graft-versus-host disease_Homo sapiens_hsa053320.66913727
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65794517
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.63748622
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63618598
75Lysine degradation_Homo sapiens_hsa003100.63465915
76Sulfur relay system_Homo sapiens_hsa041220.63250815
77Glutathione metabolism_Homo sapiens_hsa004800.62810258
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61782011
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60801250
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60025876
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59416433
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58813139
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58704277
84Fatty acid metabolism_Homo sapiens_hsa012120.57651172
85Viral myocarditis_Homo sapiens_hsa054160.55415371
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51714213
87Shigellosis_Homo sapiens_hsa051310.51172584
88Oocyte meiosis_Homo sapiens_hsa041140.50811269
89N-Glycan biosynthesis_Homo sapiens_hsa005100.50049244
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49437638
91Colorectal cancer_Homo sapiens_hsa052100.49163336
92Metabolic pathways_Homo sapiens_hsa011000.49012267
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48800899
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48581487
95Toxoplasmosis_Homo sapiens_hsa051450.46693908
96B cell receptor signaling pathway_Homo sapiens_hsa046620.46301420
97TNF signaling pathway_Homo sapiens_hsa046680.45645371
98Protein export_Homo sapiens_hsa030600.44545950
99Pentose phosphate pathway_Homo sapiens_hsa000300.42518588
100T cell receptor signaling pathway_Homo sapiens_hsa046600.41711417
101Arachidonic acid metabolism_Homo sapiens_hsa005900.41477477
102Butanoate metabolism_Homo sapiens_hsa006500.41089766
103Alcoholism_Homo sapiens_hsa050340.40258245
104Malaria_Homo sapiens_hsa051440.39948135
105Other glycan degradation_Homo sapiens_hsa005110.39638338
106TGF-beta signaling pathway_Homo sapiens_hsa043500.39044795
107Thyroid cancer_Homo sapiens_hsa052160.37190341
108Hippo signaling pathway_Homo sapiens_hsa043900.36947087
109Osteoclast differentiation_Homo sapiens_hsa043800.36120264
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35602362
111Prostate cancer_Homo sapiens_hsa052150.35597598
112Tuberculosis_Homo sapiens_hsa051520.35565248
113Selenocompound metabolism_Homo sapiens_hsa004500.35538084
114Cardiac muscle contraction_Homo sapiens_hsa042600.35326718
115FoxO signaling pathway_Homo sapiens_hsa040680.35130396
116Acute myeloid leukemia_Homo sapiens_hsa052210.34316726
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.33678119
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33346440
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33197609
120Type I diabetes mellitus_Homo sapiens_hsa049400.33114943
121Wnt signaling pathway_Homo sapiens_hsa043100.32559224
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31788261
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31393464
124Pathways in cancer_Homo sapiens_hsa052000.30409504
125Chronic myeloid leukemia_Homo sapiens_hsa052200.30046023
126Adherens junction_Homo sapiens_hsa045200.29818018
127Pancreatic cancer_Homo sapiens_hsa052120.29590048
128Notch signaling pathway_Homo sapiens_hsa043300.28252556
129Arginine and proline metabolism_Homo sapiens_hsa003300.27686254
130Vitamin B6 metabolism_Homo sapiens_hsa007500.26936875
131Pertussis_Homo sapiens_hsa051330.26577781
132Fatty acid degradation_Homo sapiens_hsa000710.26334406
133Hedgehog signaling pathway_Homo sapiens_hsa043400.26248952
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25849024
135Basal cell carcinoma_Homo sapiens_hsa052170.23472626
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20924963
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.20461713
138Hepatitis C_Homo sapiens_hsa051600.20079158
139Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.18478533
140Cyanoamino acid metabolism_Homo sapiens_hsa004600.16841937
141Caffeine metabolism_Homo sapiens_hsa002320.16077763
142Fatty acid biosynthesis_Homo sapiens_hsa000610.14922245
143Peroxisome_Homo sapiens_hsa041460.09393551
144Melanoma_Homo sapiens_hsa052180.08551238
145Arginine biosynthesis_Homo sapiens_hsa002200.08498988
146Olfactory transduction_Homo sapiens_hsa047400.05785311
147Pentose and glucuronate interconversions_Homo sapiens_hsa000400.04801756
148Nitrogen metabolism_Homo sapiens_hsa009100.04737523
149Tight junction_Homo sapiens_hsa045300.03130602
150Tryptophan metabolism_Homo sapiens_hsa003800.02979856

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