ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	acrosome reaction (GO:0007340)	9.82648582
2	sperm motility (GO:0030317)	8.84149390
3	response to pheromone (GO:0019236)	7.89904414
4	fusion of sperm to egg plasma membrane (GO:0007342)	7.75227079
5	RNA destabilization (GO:0050779)	6.75667413
6	spermatid development (GO:0007286)	6.69000600
7	axonemal dynein complex assembly (GO:0070286)	6.53779964
8	alkaloid metabolic process (GO:0009820)	6.45747245
9	cellular ketone body metabolic process (GO:0046950)	6.00920646
10	multicellular organism reproduction (GO:0032504)	5.96384613
11	plasma membrane fusion (GO:0045026)	5.86477637
12	rRNA methylation (GO:0031167)	5.63636779
13	sperm-egg recognition (GO:0035036)	5.55387890
14	calcium ion-dependent exocytosis (GO:0017156)	5.43493191
15	single strand break repair (GO:0000012)	5.32760266
16	microtubule depolymerization (GO:0007019)	5.31833108
17	ketone body metabolic process (GO:1902224)	5.28986594
18	DNA packaging (GO:0006323)	5.28098454
19	sperm capacitation (GO:0048240)	5.27920283
20	cilium or flagellum-dependent cell motility (GO:0001539)	5.22757879
21	reproduction (GO:0000003)	5.20278889
22	protein polyglutamylation (GO:0018095)	5.18497967
23	protein targeting to Golgi (GO:0000042)	5.08353595
24	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.08115125
25	establishment of protein localization to Golgi (GO:0072600)	4.95639049
26	chromosome condensation (GO:0030261)	4.94931843
27	indolalkylamine metabolic process (GO:0006586)	4.91697353
28	dopamine biosynthetic process (GO:0042416)	4.89688941
29	peptidyl-threonine dephosphorylation (GO:0035970)	4.86911364
30	spermatid nucleus differentiation (GO:0007289)	4.86349994
31	binding of sperm to zona pellucida (GO:0007339)	4.85417831
32	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.73572391
33	response to insecticide (GO:0017085)	4.71267115
34	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.69593709
35	regulation of cilium movement (GO:0003352)	4.67518682
36	cell-cell recognition (GO:0009988)	4.63464389
37	meiotic chromosome segregation (GO:0045132)	4.63082256
38	negative regulation of inclusion body assembly (GO:0090084)	4.60883997
39	spermatogenesis (GO:0007283)	4.60852288
40	male gamete generation (GO:0048232)	4.59574663
41	rRNA modification (GO:0000154)	4.53769205
42	primary amino compound metabolic process (GO:1901160)	4.52302018
43	piRNA metabolic process (GO:0034587)	4.49121771
44	serotonin metabolic process (GO:0042428)	4.42332748
45	single fertilization (GO:0007338)	4.40580416
46	histone H3-K9 methylation (GO:0051567)	4.33557998
47	epithelial cilium movement (GO:0003351)	4.33483371
48	toxin metabolic process (GO:0009404)	4.32535861
49	phosphatidylethanolamine metabolic process (GO:0046337)	4.32298231
50	gamete generation (GO:0007276)	4.28658000
51	mitochondrion degradation (GO:0000422)	4.21092109
52	microtubule polymerization or depolymerization (GO:0031109)	4.19795039
53	centriole replication (GO:0007099)	4.14923020
54	motile cilium assembly (GO:0044458)	4.08435655
55	centriole assembly (GO:0098534)	3.98028100
56	sexual reproduction (GO:0019953)	3.90073651
57	germ cell development (GO:0007281)	3.84145314
58	male meiosis I (GO:0007141)	3.82303294
59	fertilization (GO:0009566)	3.78936632
60	L-fucose catabolic process (GO:0042355)	3.76663689
61	fucose catabolic process (GO:0019317)	3.76663689
62	L-fucose metabolic process (GO:0042354)	3.76663689
63	cellular biogenic amine biosynthetic process (GO:0042401)	3.76409860
64	protein localization to Golgi apparatus (GO:0034067)	3.71751995
65	cilium movement (GO:0003341)	3.68393822
66	seminiferous tubule development (GO:0072520)	3.62429806
67	coenzyme catabolic process (GO:0009109)	3.61461648
68	amine biosynthetic process (GO:0009309)	3.57930393
69	microtubule severing (GO:0051013)	3.55720096
70	regulation of microtubule-based movement (GO:0060632)	3.54983367
71	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.51441421
72	male meiosis (GO:0007140)	3.46750664
73	positive regulation of Rab GTPase activity (GO:0032851)	3.42001055
74	regulation of Rab GTPase activity (GO:0032313)	3.42001055
75	indole-containing compound metabolic process (GO:0042430)	3.39625679
76	multicellular organismal reproductive process (GO:0048609)	3.38208846
77	organic cation transport (GO:0015695)	3.37522340
78	regulation of meiosis I (GO:0060631)	3.32695228
79	histone H3-K9 modification (GO:0061647)	3.31865720
80	DNA methylation involved in gamete generation (GO:0043046)	3.30148563
81	RNA localization (GO:0006403)	3.20702929
82	detection of light stimulus involved in sensory perception (GO:0050962)	3.15523125
83	detection of light stimulus involved in visual perception (GO:0050908)	3.15523125
84	histone H3-K4 trimethylation (GO:0080182)	3.15291634
85	meiosis I (GO:0007127)	3.11222449
86	cell wall macromolecule metabolic process (GO:0044036)	3.11127781
87	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	3.10734650
88	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	3.10734650
89	regulation of transcription involved in cell fate commitment (GO:0060850)	3.04075839
90	urinary tract smooth muscle contraction (GO:0014848)	3.02834307
91	poly(A)+ mRNA export from nucleus (GO:0016973)	3.02055063
92	regulation of inclusion body assembly (GO:0090083)	3.01940904
93	interkinetic nuclear migration (GO:0022027)	2.99444967
94	multicellular organismal aging (GO:0010259)	2.99295313
95	Golgi to endosome transport (GO:0006895)	2.91989884
96	cilium assembly (GO:0042384)	2.89556905
97	cilium organization (GO:0044782)	2.85027314
98	multicellular organismal movement (GO:0050879)	2.83571058
99	musculoskeletal movement (GO:0050881)	2.83571058
100	spinal cord motor neuron differentiation (GO:0021522)	2.81031454

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.13705710
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.91737300
3	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.67257990
4	VDR_22108803_ChIP-Seq_LS180_Human	2.64496709
5	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.62394867
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.53989752
7	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.38903668
8	FUS_26573619_Chip-Seq_HEK293_Human	2.38365758
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.36767505
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.35758925
11	CBP_20019798_ChIP-Seq_JUKART_Human	2.30203138
12	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.30203138
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.29707850
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.20362843
15	DROSHA_22980978_ChIP-Seq_HELA_Human	2.19980941
16	GBX2_23144817_ChIP-Seq_PC3_Human	2.13342154
17	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.07183064
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.02308123
19	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.98238521
20	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.98238521
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.91186222
22	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.84133877
23	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.74653926
24	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.70448143
25	P300_19829295_ChIP-Seq_ESCs_Human	1.68174623
26	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.64699385
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.58768241
28	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.55058098
29	AR_25329375_ChIP-Seq_VCAP_Human	1.54285297
30	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.53099586
31	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.49054486
32	ERA_21632823_ChIP-Seq_H3396_Human	1.47033001
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.46096460
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.46094415
35	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.44179085
36	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.43327759
37	RAC3_21632823_ChIP-Seq_H3396_Human	1.40851142
38	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.40677613
39	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.40221905
40	RUNX2_22187159_ChIP-Seq_PCA_Human	1.40122448
41	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38673320
42	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.37309845
43	STAT3_23295773_ChIP-Seq_U87_Human	1.36757786
44	NANOG_20526341_ChIP-Seq_ESCs_Human	1.36289934
45	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.36170756
46	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.34982931
47	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.34159483
48	TCF4_23295773_ChIP-Seq_U87_Human	1.33041055
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.31751668
50	AR_21572438_ChIP-Seq_LNCaP_Human	1.30196675
51	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.29196422
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28611482
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28611482
54	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.25687701
55	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.24912511
56	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.24787988
57	REST_21632747_ChIP-Seq_MESCs_Mouse	1.24712927
58	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.24659209
59	TBL1_22424771_ChIP-Seq_293T_Human	1.23969568
60	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.22685598
61	MYC_19829295_ChIP-Seq_ESCs_Human	1.21397536
62	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.19256345
63	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.17675634
64	ETV1_20927104_ChIP-Seq_GIST48_Human	1.17636065
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16650427
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16650427
67	RBPJ_21746931_ChIP-Seq_IB4_Human	1.14085050
68	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.13991328
69	EWS_26573619_Chip-Seq_HEK293_Human	1.12718571
70	SMRT_27268052_Chip-Seq_Bcells_Human	1.12569339
71	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.11439383
72	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.11168590
73	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09951313
74	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.09628315
75	BCAT_22108803_ChIP-Seq_LS180_Human	1.08860571
76	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.08805567
77	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.07762389
78	NCOR_22424771_ChIP-Seq_293T_Human	1.07579780
79	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.07554034
80	NFYB_21822215_ChIP-Seq_K562_Human	1.07528662
81	OCT4_20526341_ChIP-Seq_ESCs_Human	1.06648913
82	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.06379294
83	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04830273
84	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.04370910
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04176923
86	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.01888530
87	AHR_22903824_ChIP-Seq_MCF-7_Human	1.00745741
88	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.00221656
89	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00045056
90	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98958914
91	NFYA_21822215_ChIP-Seq_K562_Human	0.98570668
92	CTCF_27219007_Chip-Seq_Bcells_Human	0.97934848
93	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.97748517
94	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97479552
95	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.97366264
96	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.96332772
97	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.96073992
98	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.95619712
99	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.94847400
100	TAF2_19829295_ChIP-Seq_ESCs_Human	0.94830202

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	8.78024048
2	MP0000569_abnormal_digit_pigmentation	4.18959832
3	MP0003698_abnormal_male_reproductive	3.64655459
4	MP0003878_abnormal_ear_physiology	3.33485240
5	MP0005377_hearing/vestibular/ear_phenot	3.33485240
6	MP0001929_abnormal_gametogenesis	3.15246464
7	MP0005423_abnormal_somatic_nervous	3.14544763
8	MP0005670_abnormal_white_adipose	3.05982852
9	MP0008877_abnormal_DNA_methylation	2.62668518
10	MP0003880_abnormal_central_pattern	2.57420046
11	MP0003011_delayed_dark_adaptation	2.02622722
12	MP0001905_abnormal_dopamine_level	1.97658056
13	MP0005645_abnormal_hypothalamus_physiol	1.97156975
14	MP0002161_abnormal_fertility/fecundity	1.92227438
15	MP0002210_abnormal_sex_determination	1.80746883
16	MP0003787_abnormal_imprinting	1.79967396
17	MP0005310_abnormal_salivary_gland	1.79258036
18	MP0004742_abnormal_vestibular_system	1.77643760
19	MP0004484_altered_response_of	1.70530856
20	MP0002138_abnormal_hepatobiliary_system	1.66508077
21	MP0009046_muscle_twitch	1.64779064
22	MP0009745_abnormal_behavioral_response	1.64232940
23	MP0005551_abnormal_eye_electrophysiolog	1.62606380
24	MP0003646_muscle_fatigue	1.49816006
25	MP0000653_abnormal_sex_gland	1.42172734
26	MP0003718_maternal_effect	1.41967333
27	MP0004381_abnormal_hair_follicle	1.41842034
28	MP0001145_abnormal_male_reproductive	1.41521371
29	MP0001486_abnormal_startle_reflex	1.40303324
30	MP0005253_abnormal_eye_physiology	1.39474442
31	MP0002928_abnormal_bile_duct	1.39004361
32	MP0001968_abnormal_touch/_nociception	1.37691624
33	MP0002735_abnormal_chemical_nociception	1.37246906
34	MP0002572_abnormal_emotion/affect_behav	1.34746497
35	MP0002132_abnormal_respiratory_system	1.34269279
36	MP0009697_abnormal_copulation	1.34100833
37	MP0005075_abnormal_melanosome_morpholog	1.31227953
38	MP0002067_abnormal_sensory_capabilities	1.28298183
39	MP0000631_abnormal_neuroendocrine_gland	1.26625997
40	MP0006292_abnormal_olfactory_placode	1.24668573
41	MP0002064_seizures	1.24592789
42	MP0001485_abnormal_pinna_reflex	1.24003439
43	MP0002557_abnormal_social/conspecific_i	1.23752403
44	MP0000015_abnormal_ear_pigmentation	1.23694075
45	MP0002822_catalepsy	1.20928617
46	MP0002272_abnormal_nervous_system	1.19761879
47	MP0006072_abnormal_retinal_apoptosis	1.17890694
48	MP0000026_abnormal_inner_ear	1.12750208
49	MP0004859_abnormal_synaptic_plasticity	1.12209376
50	MP0003635_abnormal_synaptic_transmissio	1.09894035
51	MP0005220_abnormal_exocrine_pancreas	1.06214227
52	MP0004215_abnormal_myocardial_fiber	1.04177232
53	MP0004142_abnormal_muscle_tone	1.02352265
54	MP0001963_abnormal_hearing_physiology	0.98362828
55	MP0004885_abnormal_endolymph	0.95680997
56	MP0002693_abnormal_pancreas_physiology	0.95672690
57	MP0002127_abnormal_cardiovascular_syste	0.95421008
58	MP0002229_neurodegeneration	0.94299557
59	MP0005646_abnormal_pituitary_gland	0.92488712
60	MP0002733_abnormal_thermal_nociception	0.91419486
61	MP0006276_abnormal_autonomic_nervous	0.90967095
62	MP0005084_abnormal_gallbladder_morpholo	0.90185612
63	MP0001293_anophthalmia	0.88483073
64	MP0002063_abnormal_learning/memory/cond	0.88216297
65	MP0001879_abnormal_lymphatic_vessel	0.86091513
66	MP0001764_abnormal_homeostasis	0.85273476
67	MP0000955_abnormal_spinal_cord	0.85075784
68	MP0001970_abnormal_pain_threshold	0.83946993
69	MP0008872_abnormal_physiological_respon	0.82658365
70	MP0005332_abnormal_amino_acid	0.81947939
71	MP0001348_abnormal_lacrimal_gland	0.81761710
72	MP0005379_endocrine/exocrine_gland_phen	0.80896290
73	MP0002184_abnormal_innervation	0.78569161
74	MP0001765_abnormal_ion_homeostasis	0.78000247
75	MP0005535_abnormal_body_temperature	0.76354871
76	MP0002102_abnormal_ear_morphology	0.76106148
77	MP0002234_abnormal_pharynx_morphology	0.75257164
78	MP0009115_abnormal_fat_cell	0.73421809
79	MP0005395_other_phenotype	0.71092293
80	MP0003195_calcinosis	0.70801950
81	MP0003942_abnormal_urinary_system	0.69242192
82	MP0004085_abnormal_heartbeat	0.67279225
83	MP0003121_genomic_imprinting	0.65200044
84	MP0005085_abnormal_gallbladder_physiolo	0.62306085
85	MP0005391_vision/eye_phenotype	0.61487285
86	MP0010386_abnormal_urinary_bladder	0.61397806
87	MP0003631_nervous_system_phenotype	0.61223592
88	MP0000534_abnormal_ureter_morphology	0.61067753
89	MP0001986_abnormal_taste_sensitivity	0.60900023
90	MP0002882_abnormal_neuron_morphology	0.60186813
91	MP0002752_abnormal_somatic_nervous	0.60004137
92	MP0008569_lethality_at_weaning	0.59708039
93	MP0002249_abnormal_larynx_morphology	0.58963889
94	MP0003633_abnormal_nervous_system	0.58096340
95	MP0001324_abnormal_eye_pigmentation	0.56859625
96	MP0001286_abnormal_eye_development	0.55521965
97	MP0003638_abnormal_response/metabolism_	0.50078239
98	MP0005167_abnormal_blood-brain_barrier	0.49817422
99	MP0000230_abnormal_systemic_arterial	0.48810440
100	MP0004924_abnormal_behavior	0.48025414

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypothermia (HP:0002045)	6.13318147
2	Severe visual impairment (HP:0001141)	6.09713480
3	Abnormal pupillary function (HP:0007686)	5.99236596
4	Limb dystonia (HP:0002451)	5.95680755
5	Bony spicule pigmentary retinopathy (HP:0007737)	5.33420378
6	Limb hypertonia (HP:0002509)	4.66282162
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.59659042
8	Absent/shortened dynein arms (HP:0200106)	4.59659042
9	Attenuation of retinal blood vessels (HP:0007843)	4.56746170
10	Chronic hepatic failure (HP:0100626)	4.41919927
11	Abnormal rod and cone electroretinograms (HP:0008323)	4.35418999
12	Abnormal respiratory epithelium morphology (HP:0012253)	4.28485710
13	Abnormal respiratory motile cilium morphology (HP:0005938)	4.28485710
14	Abnormal respiratory motile cilium physiology (HP:0012261)	4.27210793
15	Abnormal ciliary motility (HP:0012262)	4.18224698
16	Medial flaring of the eyebrow (HP:0010747)	3.67513611
17	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.59791678
18	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.52799712
19	Acute lymphatic leukemia (HP:0006721)	3.48132193
20	Retinal dysplasia (HP:0007973)	3.36913849
21	Decreased central vision (HP:0007663)	3.23981791
22	Hyperkalemia (HP:0002153)	3.16625249
23	Type II lissencephaly (HP:0007260)	3.00397839
24	Abnormality of macular pigmentation (HP:0008002)	2.98997930
25	Rhinitis (HP:0012384)	2.91494934
26	Abnormal drinking behavior (HP:0030082)	2.86926255
27	Polydipsia (HP:0001959)	2.86926255
28	Nephronophthisis (HP:0000090)	2.85059689
29	Abnormality of midbrain morphology (HP:0002418)	2.83738187
30	Molar tooth sign on MRI (HP:0002419)	2.83738187
31	Impulsivity (HP:0100710)	2.83296813
32	Progressive cerebellar ataxia (HP:0002073)	2.82424767
33	Generalized aminoaciduria (HP:0002909)	2.76922242
34	Mesangial abnormality (HP:0001966)	2.66498113
35	Resting tremor (HP:0002322)	2.63712427
36	Cerebellar dysplasia (HP:0007033)	2.56733114
37	Renal Fanconi syndrome (HP:0001994)	2.56358689
38	Postural instability (HP:0002172)	2.53784183
39	Infertility (HP:0000789)	2.47380442
40	Focal motor seizures (HP:0011153)	2.45917723
41	Pigmentary retinal degeneration (HP:0001146)	2.40857978
42	Portal hypertension (HP:0001409)	2.34619140
43	Abnormal urine output (HP:0012590)	2.34466025
44	Abnormality of the renal medulla (HP:0100957)	2.33124031
45	Polyuria (HP:0000103)	2.28824520
46	Chronic sinusitis (HP:0011109)	2.28041592
47	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.27407975
48	Abnormality of the pubic bones (HP:0003172)	2.23285122
49	Type 2 muscle fiber atrophy (HP:0003554)	2.22612966
50	3-Methylglutaconic aciduria (HP:0003535)	2.22352502
51	Truncal obesity (HP:0001956)	2.20734399
52	Potter facies (HP:0002009)	2.19615372
53	Facial shape deformation (HP:0011334)	2.19615372
54	Glycosuria (HP:0003076)	2.18190787
55	Abnormality of urine glucose concentration (HP:0011016)	2.18190787
56	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.17976357
57	Bile duct proliferation (HP:0001408)	2.16717198
58	Abnormal biliary tract physiology (HP:0012439)	2.16717198
59	Hypoplastic ischia (HP:0003175)	2.15331693
60	Tubulointerstitial nephritis (HP:0001970)	2.14629720
61	Pancreatic cysts (HP:0001737)	2.14595898
62	Abnormality of the hepatic vasculature (HP:0006707)	2.13343086
63	Bronchiectasis (HP:0002110)	2.04444526
64	Chronic bronchitis (HP:0004469)	2.04014707
65	Pancreatic fibrosis (HP:0100732)	2.01774564
66	Abnormality of incisor morphology (HP:0011063)	2.00579260
67	Genetic anticipation (HP:0003743)	1.99377029
68	Abnormality of renal excretion (HP:0011036)	1.94025880
69	Midline defect of the nose (HP:0004122)	1.92776935
70	Large for gestational age (HP:0001520)	1.92557957
71	Asymmetric septal hypertrophy (HP:0001670)	1.91988298
72	Amelogenesis imperfecta (HP:0000705)	1.91868837
73	Exertional dyspnea (HP:0002875)	1.91683094
74	Inability to walk (HP:0002540)	1.88127040
75	Thyroid-stimulating hormone excess (HP:0002925)	1.87221228
76	Muscle fiber atrophy (HP:0100295)	1.87070709
77	Abnormality of the ischium (HP:0003174)	1.86686034
78	Optic nerve hypoplasia (HP:0000609)	1.83904050
79	Stage 5 chronic kidney disease (HP:0003774)	1.83350205
80	Abnormality of potassium homeostasis (HP:0011042)	1.81609202
81	Dialeptic seizures (HP:0011146)	1.80740866
82	Hypoplasia of the thymus (HP:0000778)	1.80144546
83	Lipid accumulation in hepatocytes (HP:0006561)	1.80003499
84	Male infertility (HP:0003251)	1.77954895
85	Enlarged epiphyses (HP:0010580)	1.77109218
86	Cone-rod dystrophy (HP:0000548)	1.76013805
87	Abnormal spermatogenesis (HP:0008669)	1.74762414
88	Prominent nasal bridge (HP:0000426)	1.74421915
89	Myokymia (HP:0002411)	1.73224535
90	Nasal polyposis (HP:0100582)	1.68201758
91	Photophobia (HP:0000613)	1.64781771
92	Multicystic kidney dysplasia (HP:0000003)	1.64278686
93	Fatigable weakness (HP:0003473)	1.63709523
94	Abnormality of the neuromuscular junction (HP:0003398)	1.63709523
95	Gait imbalance (HP:0002141)	1.63597834
96	Vaginal atresia (HP:0000148)	1.63260758
97	Bulbous nose (HP:0000414)	1.63042532
98	Genital tract atresia (HP:0001827)	1.61788750
99	Focal segmental glomerulosclerosis (HP:0000097)	1.60251931
100	Abnormality of renal resorption (HP:0011038)	1.57882474

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	5.63142600
2	BLK	4.48467687
3	PLK4	4.06623670
4	PINK1	3.21229894
5	MAP4K2	3.10025898
6	BRD4	3.07243364
7	TESK1	2.77971529
8	FRK	2.39940838
9	ADRBK2	2.36076875
10	PNCK	2.13575677
11	INSRR	2.05683416
12	PDK1	2.00692371
13	CDK19	1.93495330
14	PDPK1	1.93227440
15	CAMK1G	1.89739089
16	DDR2	1.88361785
17	STK38	1.87084447
18	LATS1	1.70323811
19	TAF1	1.59458372
20	MARK1	1.57324662
21	OXSR1	1.37016422
22	GRK1	1.35927493
23	STK38L	1.33190980
24	PTK2B	1.31605014
25	CAMK1D	1.28438589
26	MAP3K7	1.25939964
27	PIK3CG	1.25236811
28	NTRK2	1.21882315
29	SIK2	1.21720228
30	MAPK15	1.20922471
31	CAMK4	1.20361012
32	MUSK	1.07625969
33	PLK2	1.06504352
34	NUAK1	1.05896274
35	MAPK13	1.01336669
36	TLK1	1.00814986
37	RIPK4	0.94326565
38	CAMK1	0.92476572
39	STK39	0.92250772
40	CDK3	0.90172322
41	DAPK2	0.90086574
42	KIT	0.86682677
43	FLT3	0.83104287
44	PRKD3	0.82434191
45	DYRK2	0.81999405
46	SYK	0.74195151
47	MAP3K4	0.72750151
48	MAPKAPK5	0.71207145
49	MARK2	0.70150985
50	BRAF	0.69387546
51	NEK2	0.68923815
52	MAP2K7	0.65693671
53	CAMKK2	0.65474096
54	VRK1	0.65472961
55	PRKCE	0.63827609
56	FGFR2	0.62470874
57	PRKG1	0.62072954
58	BMPR1B	0.62053830
59	TYRO3	0.61303112
60	ACVR1B	0.60823354
61	TEC	0.58117654
62	PRKCG	0.57650901
63	OBSCN	0.57188635
64	WNK1	0.56053293
65	CSF1R	0.55544720
66	MAP2K2	0.54678387
67	RPS6KA4	0.52973242
68	MARK3	0.52902185
69	PKN1	0.46218887
70	STK3	0.46050478
71	TXK	0.45773182
72	DYRK1B	0.45493891
73	RPS6KA5	0.45454278
74	FES	0.42649472
75	NEK6	0.42072861
76	PRKG2	0.40089319
77	PRKACB	0.39945475
78	CDK7	0.39521291
79	WNK3	0.39041755
80	WNK4	0.36748249
81	GSK3B	0.36563734
82	HIPK2	0.36439488
83	PASK	0.35621157
84	CAMK2A	0.34891434
85	MAPK12	0.34642458
86	ROCK1	0.32022934
87	SGK1	0.31704582
88	MAP3K2	0.30585317
89	ADRBK1	0.30446218
90	RPS6KA1	0.29298494
91	LYN	0.28475436
92	ITK	0.28402062
93	CDK1	0.26548313
94	UHMK1	0.26392639
95	MAPK7	0.25538560
96	PRKCB	0.24566186
97	STK16	0.24395393
98	MAPK14	0.23831315
99	MAPK1	0.23805199
100	MYLK	0.23734204

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.25957534
2	Phenylalanine metabolism_Homo sapiens_hsa00360	3.60947947
3	Dorso-ventral axis formation_Homo sapiens_hsa04320	3.16422852
4	Butanoate metabolism_Homo sapiens_hsa00650	2.67809514
5	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.65094412
6	Olfactory transduction_Homo sapiens_hsa04740	2.64214090
7	Nicotine addiction_Homo sapiens_hsa05033	2.61177557
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.35075829
9	Phototransduction_Homo sapiens_hsa04744	2.32628254
10	Tryptophan metabolism_Homo sapiens_hsa00380	2.24051575
11	Histidine metabolism_Homo sapiens_hsa00340	2.07636710
12	Cocaine addiction_Homo sapiens_hsa05030	1.95427596
13	Serotonergic synapse_Homo sapiens_hsa04726	1.75402309
14	Morphine addiction_Homo sapiens_hsa05032	1.71875847
15	Amphetamine addiction_Homo sapiens_hsa05031	1.71730395
16	Taste transduction_Homo sapiens_hsa04742	1.70422782
17	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.61505533
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.59886538
19	Regulation of autophagy_Homo sapiens_hsa04140	1.59834925
20	Tyrosine metabolism_Homo sapiens_hsa00350	1.52825339
21	Type I diabetes mellitus_Homo sapiens_hsa04940	1.52474430
22	Allograft rejection_Homo sapiens_hsa05330	1.46049786
23	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.41696995
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.31598781
25	Graft-versus-host disease_Homo sapiens_hsa05332	1.30186561
26	Basal transcription factors_Homo sapiens_hsa03022	1.29176142
27	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.26301712
28	Propanoate metabolism_Homo sapiens_hsa00640	1.26156556
29	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.25546195
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.24487016
31	Fatty acid degradation_Homo sapiens_hsa00071	1.24454370
32	Circadian entrainment_Homo sapiens_hsa04713	1.24236215
33	GABAergic synapse_Homo sapiens_hsa04727	1.23933638
34	Caffeine metabolism_Homo sapiens_hsa00232	1.17931611
35	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.14707420
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.14507236
37	Dopaminergic synapse_Homo sapiens_hsa04728	1.09767262
38	Asthma_Homo sapiens_hsa05310	1.09729918
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.08187791
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.00631083
41	Calcium signaling pathway_Homo sapiens_hsa04020	0.98537353
42	Glutamatergic synapse_Homo sapiens_hsa04724	0.94664298
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.92940325
44	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.91237929
45	Cholinergic synapse_Homo sapiens_hsa04725	0.90523008
46	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.89874436
47	Renin secretion_Homo sapiens_hsa04924	0.89654843
48	Oxidative phosphorylation_Homo sapiens_hsa00190	0.87357449
49	Nitrogen metabolism_Homo sapiens_hsa00910	0.87020162
50	Type II diabetes mellitus_Homo sapiens_hsa04930	0.85396264
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.84417538
52	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.82789788
53	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.81550800
54	Long-term depression_Homo sapiens_hsa04730	0.80293134
55	Antigen processing and presentation_Homo sapiens_hsa04612	0.77602908
56	Huntingtons disease_Homo sapiens_hsa05016	0.75900424
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.74986688
58	Parkinsons disease_Homo sapiens_hsa05012	0.70167019
59	Ether lipid metabolism_Homo sapiens_hsa00565	0.69765794
60	cAMP signaling pathway_Homo sapiens_hsa04024	0.66897547
61	RNA transport_Homo sapiens_hsa03013	0.64508600
62	Gap junction_Homo sapiens_hsa04540	0.60199162
63	Insulin secretion_Homo sapiens_hsa04911	0.59641826
64	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.58807968
65	Salivary secretion_Homo sapiens_hsa04970	0.56707054
66	Purine metabolism_Homo sapiens_hsa00230	0.56195894
67	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.56045875
68	Alcoholism_Homo sapiens_hsa05034	0.55648864
69	ABC transporters_Homo sapiens_hsa02010	0.55065541
70	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.54249324
71	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.54142001
72	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.54035412
73	MAPK signaling pathway_Homo sapiens_hsa04010	0.53394536
74	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52351802
75	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.49546852
76	Estrogen signaling pathway_Homo sapiens_hsa04915	0.49092882
77	Chemical carcinogenesis_Homo sapiens_hsa05204	0.46536334
78	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.43930030
79	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.42197666
80	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.41385349
81	PPAR signaling pathway_Homo sapiens_hsa03320	0.40964891
82	Lysine degradation_Homo sapiens_hsa00310	0.40551679
83	Oocyte meiosis_Homo sapiens_hsa04114	0.39491652
84	Retinol metabolism_Homo sapiens_hsa00830	0.39333125
85	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.37852572
86	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.34167731
87	mRNA surveillance pathway_Homo sapiens_hsa03015	0.33839136
88	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.32994950
89	Fanconi anemia pathway_Homo sapiens_hsa03460	0.32315231
90	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.31642166
91	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.31018009
92	Metabolic pathways_Homo sapiens_hsa01100	0.30974099
93	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.30846882
94	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.29684409
95	Long-term potentiation_Homo sapiens_hsa04720	0.29145704
96	FoxO signaling pathway_Homo sapiens_hsa04068	0.28594593
97	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.27980814
98	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.27491867
99	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.27137511
100	Influenza A_Homo sapiens_hsa05164	0.25673337

LINC00083

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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