ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement (GO:0003351)	4.54665539
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.45906000
3	axonemal dynein complex assembly (GO:0070286)	4.28284579
4	cilium movement (GO:0003341)	4.23357340
5	pyrimidine nucleobase catabolic process (GO:0006208)	4.21491117
6	cilium or flagellum-dependent cell motility (GO:0001539)	3.97547996
7	postsynaptic membrane organization (GO:0001941)	3.85129175
8	neuron cell-cell adhesion (GO:0007158)	3.80667462
9	behavioral response to nicotine (GO:0035095)	3.72878314
10	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.60198722
11	nonmotile primary cilium assembly (GO:0035058)	3.56791788
12	gamma-aminobutyric acid transport (GO:0015812)	3.54606815
13	protein localization to synapse (GO:0035418)	3.50027725
14	regulation of cilium movement (GO:0003352)	3.47043763
15	nucleobase catabolic process (GO:0046113)	3.40855012
16	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.38762117
17	presynaptic membrane assembly (GO:0097105)	3.38421156
18	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.29100872
19	presynaptic membrane organization (GO:0097090)	3.28486698
20	synaptic vesicle maturation (GO:0016188)	3.25388726
21	intraciliary transport (GO:0042073)	3.22338730
22	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.22215154
23	vocalization behavior (GO:0071625)	3.21255469
24	protein localization to cilium (GO:0061512)	3.15958524
25	axonal fasciculation (GO:0007413)	3.15739982
26	transmission of nerve impulse (GO:0019226)	3.15057480
27	synaptic vesicle exocytosis (GO:0016079)	3.14700720
28	glutamate secretion (GO:0014047)	3.13022229
29	response to pheromone (GO:0019236)	3.08299182
30	axoneme assembly (GO:0035082)	3.05795482
31	cilium organization (GO:0044782)	3.05708693
32	synaptic transmission, glutamatergic (GO:0035249)	3.05090320
33	synapse assembly (GO:0007416)	3.04712036
34	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.02951883
35	cilium assembly (GO:0042384)	3.02046503
36	cilium morphogenesis (GO:0060271)	3.01728152
37	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.99811826
38	motile cilium assembly (GO:0044458)	2.99116960
39	dendritic spine morphogenesis (GO:0060997)	2.98526977
40	neuronal action potential propagation (GO:0019227)	2.97940665
41	positive regulation of mitochondrial fission (GO:0090141)	2.96255655
42	left/right pattern formation (GO:0060972)	2.94165338
43	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.87962892
44	neuron recognition (GO:0008038)	2.86502435
45	neuron-neuron synaptic transmission (GO:0007270)	2.82005758
46	regulation of microtubule-based movement (GO:0060632)	2.81137951
47	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.81002427
48	retinal cone cell development (GO:0046549)	2.78329950
49	protein polyglutamylation (GO:0018095)	2.77430995
50	neurotransmitter secretion (GO:0007269)	2.76801063
51	regulation of synaptic vesicle transport (GO:1902803)	2.76359082
52	glutamate receptor signaling pathway (GO:0007215)	2.73735485
53	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.71635368
54	regulation of synapse structural plasticity (GO:0051823)	2.69942772
55	auditory behavior (GO:0031223)	2.68412115
56	cell migration in hindbrain (GO:0021535)	2.67785681
57	glycosphingolipid biosynthetic process (GO:0006688)	2.62852471
58	behavioral response to ethanol (GO:0048149)	2.61966389
59	substrate-independent telencephalic tangential migration (GO:0021826)	2.61191069
60	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.61191069
61	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.59977154
62	cornea development in camera-type eye (GO:0061303)	2.58589035
63	positive regulation of synapse assembly (GO:0051965)	2.58198726
64	regulation of neurotransmitter uptake (GO:0051580)	2.58062487
65	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.56572410
66	regulation of synaptic vesicle exocytosis (GO:2000300)	2.55641973
67	locomotory exploration behavior (GO:0035641)	2.55198434
68	axon ensheathment in central nervous system (GO:0032291)	2.55074290
69	central nervous system myelination (GO:0022010)	2.55074290
70	startle response (GO:0001964)	2.51569427
71	smoothened signaling pathway (GO:0007224)	2.51515273
72	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.50326373
73	neurotransmitter-gated ion channel clustering (GO:0072578)	2.49111889
74	regulation of respiratory system process (GO:0044065)	2.48404512
75	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.48194625
76	positive regulation of membrane potential (GO:0045838)	2.47460792
77	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.46198818
78	retinal ganglion cell axon guidance (GO:0031290)	2.45671383
79	synaptic vesicle endocytosis (GO:0048488)	2.44296104
80	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.42997599
81	behavioral defense response (GO:0002209)	2.42861260
82	behavioral fear response (GO:0001662)	2.42861260
83	neuromuscular synaptic transmission (GO:0007274)	2.42752889
84	hippocampus development (GO:0021766)	2.42691856
85	negative regulation of axon extension (GO:0030517)	2.41661863
86	neuronal ion channel clustering (GO:0045161)	2.39658648
87	membrane depolarization during action potential (GO:0086010)	2.37489137
88	cellular component assembly involved in morphogenesis (GO:0010927)	2.36210035
89	exploration behavior (GO:0035640)	2.33733709
90	synapse organization (GO:0050808)	2.32458108
91	regulation of neurotransmitter levels (GO:0001505)	2.31924328
92	behavioral response to cocaine (GO:0048148)	2.31530413
93	establishment of mitochondrion localization (GO:0051654)	2.31190569
94	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.30390844
95	appendage development (GO:0048736)	2.27885895
96	limb development (GO:0060173)	2.27885895
97	fear response (GO:0042596)	2.27156865
98	positive regulation of amine transport (GO:0051954)	2.25251844
99	spinal cord development (GO:0021510)	2.24696278
100	microtubule bundle formation (GO:0001578)	2.24675143

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.46763650
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.45826221
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.27658702
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.94004085
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.66980782
6	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.51495800
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.28603206
8	REST_21632747_ChIP-Seq_MESCs_Mouse	2.27345281
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.23814986
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.23713462
11	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.04612574
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.03401241
13	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.00041329
14	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.94798526
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.94210423
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.93814563
17	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.93121111
18	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.92187116
19	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.91702584
20	VDR_22108803_ChIP-Seq_LS180_Human	1.91046846
21	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.82537945
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.78044401
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.75230122
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.74622099
25	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.74600932
26	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.72982815
27	FUS_26573619_Chip-Seq_HEK293_Human	1.72927569
28	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.68820086
29	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.68521933
30	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.67893554
31	RNF2_27304074_Chip-Seq_NSC_Mouse	1.64572153
32	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.59042995
33	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.58106471
34	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.57928314
35	P300_19829295_ChIP-Seq_ESCs_Human	1.56980907
36	EWS_26573619_Chip-Seq_HEK293_Human	1.55290667
37	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.55022742
38	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.54614446
39	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.52643694
40	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.51561900
41	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.49317724
42	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.46400514
43	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.42836577
44	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.42836577
45	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.40151104
46	SMAD4_21799915_ChIP-Seq_A2780_Human	1.38886738
47	DROSHA_22980978_ChIP-Seq_HELA_Human	1.36187633
48	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.34248296
49	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.33009818
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32313316
51	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.27971198
52	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25223435
53	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.25223435
54	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.24351317
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.24210913
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.24210913
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.23298134
58	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.20931154
59	ER_23166858_ChIP-Seq_MCF-7_Human	1.20286937
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.19379172
61	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.18594668
62	AR_25329375_ChIP-Seq_VCAP_Human	1.18384970
63	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.17178057
64	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.17073651
65	AR_21572438_ChIP-Seq_LNCaP_Human	1.16607240
66	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.14467177
67	MYC_18940864_ChIP-ChIP_HL60_Human	1.12942218
68	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.12328361
69	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.11501635
70	STAT3_23295773_ChIP-Seq_U87_Human	1.11256316
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.10813103
72	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09595177
73	TP53_22573176_ChIP-Seq_HFKS_Human	1.09011479
74	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.07568165
75	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.06148469
76	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.05689065
77	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.04471468
78	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.03483972
79	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.01878664
80	IRF1_19129219_ChIP-ChIP_H3396_Human	1.00847336
81	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.00296895
82	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00230852
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.98994387
84	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.98081764
85	TCF4_23295773_ChIP-Seq_U87_Human	0.97777227
86	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.97714876
87	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.97556945
88	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97124759
89	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.96407899
90	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.95769313
91	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95762655
92	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.95122856
93	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93425924
94	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.91859413
95	NCOR_22424771_ChIP-Seq_293T_Human	0.89626982
96	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.87259709
97	BCAT_22108803_ChIP-Seq_LS180_Human	0.86643108
98	JUN_21703547_ChIP-Seq_K562_Human	0.85576291
99	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.85514200
100	AR_19668381_ChIP-Seq_PC3_Human	0.85466722

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.39056446
2	MP0004859_abnormal_synaptic_plasticity	3.30265633
3	MP0002653_abnormal_ependyma_morphology	2.89953779
4	MP0005423_abnormal_somatic_nervous	2.48241519
5	MP0001968_abnormal_touch/_nociception	2.41448034
6	MP0003635_abnormal_synaptic_transmissio	2.40133485
7	MP0009745_abnormal_behavioral_response	2.35486984
8	MP0002102_abnormal_ear_morphology	2.30219329
9	MP0004270_analgesia	2.26376923
10	MP0009046_muscle_twitch	2.21121948
11	MP0002272_abnormal_nervous_system	2.17326031
12	MP0001984_abnormal_olfaction	2.17269634
13	MP0002736_abnormal_nociception_after	2.15348810
14	MP0004133_heterotaxia	2.14134320
15	MP0005499_abnormal_olfactory_system	2.11026527
16	MP0005394_taste/olfaction_phenotype	2.11026527
17	MP0002064_seizures	2.10944319
18	MP0000778_abnormal_nervous_system	2.10411707
19	MP0001529_abnormal_vocalization	2.05243320
20	MP0008789_abnormal_olfactory_epithelium	2.04112771
21	MP0006276_abnormal_autonomic_nervous	2.03236004
22	MP0002063_abnormal_learning/memory/cond	2.00045470
23	MP0002572_abnormal_emotion/affect_behav	1.97125047
24	MP0001486_abnormal_startle_reflex	1.91379446
25	MP0003787_abnormal_imprinting	1.87505465
26	MP0002734_abnormal_mechanical_nocicepti	1.85319187
27	MP0006072_abnormal_retinal_apoptosis	1.81630999
28	MP0002822_catalepsy	1.81371212
29	MP0008877_abnormal_DNA_methylation	1.76598577
30	MP0004885_abnormal_endolymph	1.71736424
31	MP0002735_abnormal_chemical_nociception	1.65793103
32	MP0002557_abnormal_social/conspecific_i	1.64306299
33	MP0005551_abnormal_eye_electrophysiolog	1.63934867
34	MP0003122_maternal_imprinting	1.63839020
35	MP0005646_abnormal_pituitary_gland	1.63833178
36	MP0001188_hyperpigmentation	1.60637863
37	MP0002638_abnormal_pupillary_reflex	1.60366345
38	MP0003136_yellow_coat_color	1.50932310
39	MP0001905_abnormal_dopamine_level	1.48644749
40	MP0005253_abnormal_eye_physiology	1.47885355
41	MP0006292_abnormal_olfactory_placode	1.45411716
42	MP0001986_abnormal_taste_sensitivity	1.43599802
43	MP0000049_abnormal_middle_ear	1.43569833
44	MP0000631_abnormal_neuroendocrine_gland	1.42111384
45	MP0000955_abnormal_spinal_cord	1.39121396
46	MP0001970_abnormal_pain_threshold	1.38720483
47	MP0004142_abnormal_muscle_tone	1.37003597
48	MP0002067_abnormal_sensory_capabilities	1.36592019
49	MP0002184_abnormal_innervation	1.35849281
50	MP0009780_abnormal_chondrocyte_physiolo	1.32987348
51	MP0002882_abnormal_neuron_morphology	1.31654014
52	MP0001502_abnormal_circadian_rhythm	1.26971848
53	MP0010386_abnormal_urinary_bladder	1.24098352
54	MP0004811_abnormal_neuron_physiology	1.23132320
55	MP0005386_behavior/neurological_phenoty	1.21627465
56	MP0004924_abnormal_behavior	1.21627465
57	MP0002733_abnormal_thermal_nociception	1.18943978
58	MP0003121_genomic_imprinting	1.15791634
59	MP0002752_abnormal_somatic_nervous	1.15341043
60	MP0000026_abnormal_inner_ear	1.12357910
61	MP0001501_abnormal_sleep_pattern	1.07726148
62	MP0001485_abnormal_pinna_reflex	1.07177361
63	MP0002152_abnormal_brain_morphology	1.07171427
64	MP0003011_delayed_dark_adaptation	1.06774402
65	MP0008875_abnormal_xenobiotic_pharmacok	1.05103808
66	MP0002234_abnormal_pharynx_morphology	1.02182083
67	MP0003283_abnormal_digestive_organ	1.01685561
68	MP0002066_abnormal_motor_capabilities/c	1.01209853
69	MP0002876_abnormal_thyroid_physiology	1.00160508
70	MP0002909_abnormal_adrenal_gland	0.99610577
71	MP0002160_abnormal_reproductive_system	0.99482324
72	MP0002233_abnormal_nose_morphology	0.99061616
73	MP0001963_abnormal_hearing_physiology	0.98701293
74	MP0003119_abnormal_digestive_system	0.97293428
75	MP0004742_abnormal_vestibular_system	0.95660544
76	MP0002751_abnormal_autonomic_nervous	0.94501115
77	MP0003938_abnormal_ear_development	0.94165835
78	MP0004043_abnormal_pH_regulation	0.94084896
79	MP0003937_abnormal_limbs/digits/tail_de	0.92390118
80	MP0003861_abnormal_nervous_system	0.91042131
81	MP0001299_abnormal_eye_distance/	0.90509425
82	MP0000566_synostosis	0.90476936
83	MP0002938_white_spotting	0.89388411
84	MP0002928_abnormal_bile_duct	0.88055182
85	MP0005084_abnormal_gallbladder_morpholo	0.87465281
86	MP0005195_abnormal_posterior_eye	0.87387249
87	MP0008569_lethality_at_weaning	0.85730949
88	MP0003879_abnormal_hair_cell	0.84373669
89	MP0001270_distended_abdomen	0.84314421
90	MP0002229_neurodegeneration	0.83866049
91	MP0008872_abnormal_physiological_respon	0.82589329
92	MP0005391_vision/eye_phenotype	0.81571855
93	MP0000427_abnormal_hair_cycle	0.80605138
94	MP0002069_abnormal_eating/drinking_beha	0.77563111
95	MP0005171_absent_coat_pigmentation	0.76989361
96	MP0005623_abnormal_meninges_morphology	0.76340151
97	MP0000569_abnormal_digit_pigmentation	0.76200341
98	MP0001293_anophthalmia	0.75101542
99	MP0001440_abnormal_grooming_behavior	0.75003213
100	MP0003755_abnormal_palate_morphology	0.74461273

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory epithelium morphology (HP:0012253)	3.99349524
2	Abnormal respiratory motile cilium morphology (HP:0005938)	3.99349524
3	Abnormality of midbrain morphology (HP:0002418)	3.87761885
4	Molar tooth sign on MRI (HP:0002419)	3.87761885
5	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.79939208
6	True hermaphroditism (HP:0010459)	3.79847120
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.79233547
8	Absent/shortened dynein arms (HP:0200106)	3.79233547
9	Pancreatic fibrosis (HP:0100732)	3.77125638
10	Pancreatic cysts (HP:0001737)	3.70666962
11	Abnormal ciliary motility (HP:0012262)	3.66820195
12	Abnormal respiratory motile cilium physiology (HP:0012261)	3.57849170
13	Medial flaring of the eyebrow (HP:0010747)	3.52669417
14	Nephronophthisis (HP:0000090)	3.48306763
15	Gait imbalance (HP:0002141)	3.40930767
16	Myokymia (HP:0002411)	3.26273692
17	Focal motor seizures (HP:0011153)	3.12810411
18	Congenital primary aphakia (HP:0007707)	3.09641914
19	Rhinitis (HP:0012384)	3.07953696
20	Occipital encephalocele (HP:0002085)	2.94189699
21	Nephrogenic diabetes insipidus (HP:0009806)	2.90279891
22	Cystic liver disease (HP:0006706)	2.81538930
23	Focal seizures (HP:0007359)	2.81137868
24	Abnormality of the renal medulla (HP:0100957)	2.79006623
25	Febrile seizures (HP:0002373)	2.63980633
26	Hyperventilation (HP:0002883)	2.55102982
27	Chronic hepatic failure (HP:0100626)	2.49349359
28	Type II lissencephaly (HP:0007260)	2.47403082
29	Atonic seizures (HP:0010819)	2.44031514
30	Epileptic encephalopathy (HP:0200134)	2.41622440
31	Broad-based gait (HP:0002136)	2.39258371
32	Congenital stationary night blindness (HP:0007642)	2.38456455
33	Postaxial foot polydactyly (HP:0001830)	2.37851064
34	Progressive cerebellar ataxia (HP:0002073)	2.36928942
35	Postaxial hand polydactyly (HP:0001162)	2.36695990
36	Vaginal atresia (HP:0000148)	2.36131666
37	Genital tract atresia (HP:0001827)	2.36119555
38	Retinal dysplasia (HP:0007973)	2.35245404
39	Lissencephaly (HP:0001339)	2.34824233
40	Absent speech (HP:0001344)	2.32123647
41	Hemiparesis (HP:0001269)	2.31446855
42	Sclerocornea (HP:0000647)	2.30426726
43	Polyphagia (HP:0002591)	2.28585627
44	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.23559648
45	Anencephaly (HP:0002323)	2.20220872
46	Abnormality of the labia minora (HP:0012880)	2.18445903
47	Poor coordination (HP:0002370)	2.12267170
48	Limb dystonia (HP:0002451)	2.09673452
49	Inability to walk (HP:0002540)	2.08459831
50	Specific learning disability (HP:0001328)	2.06383097
51	Pachygyria (HP:0001302)	2.04628825
52	Preaxial hand polydactyly (HP:0001177)	2.04297780
53	Bile duct proliferation (HP:0001408)	2.02136163
54	Abnormal biliary tract physiology (HP:0012439)	2.02136163
55	Male pseudohermaphroditism (HP:0000037)	2.01583510
56	Epileptiform EEG discharges (HP:0011182)	1.99247014
57	Congenital hepatic fibrosis (HP:0002612)	1.97767055
58	Hypsarrhythmia (HP:0002521)	1.93677830
59	EEG with generalized epileptiform discharges (HP:0011198)	1.93518619
60	Abnormal drinking behavior (HP:0030082)	1.92486912
61	Polydipsia (HP:0001959)	1.92486912
62	Drooling (HP:0002307)	1.90348119
63	Tubular atrophy (HP:0000092)	1.87555442
64	Dialeptic seizures (HP:0011146)	1.82781728
65	Generalized tonic-clonic seizures (HP:0002069)	1.82679322
66	Aplasia/Hypoplasia of the lens (HP:0008063)	1.81798893
67	Optic nerve hypoplasia (HP:0000609)	1.81604469
68	Abnormality of the renal cortex (HP:0011035)	1.81040953
69	Abnormality of the lower motor neuron (HP:0002366)	1.78874363
70	Hypoplasia of the brainstem (HP:0002365)	1.78637827
71	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.78637827
72	Acute necrotizing encephalopathy (HP:0006965)	1.76818742
73	Abnormal eating behavior (HP:0100738)	1.76716842
74	Progressive inability to walk (HP:0002505)	1.76200550
75	Infertility (HP:0000789)	1.75844981
76	Narrow forehead (HP:0000341)	1.74945121
77	Aganglionic megacolon (HP:0002251)	1.74651366
78	Anophthalmia (HP:0000528)	1.74607565
79	Keratoconus (HP:0000563)	1.74523260
80	Increased corneal curvature (HP:0100692)	1.74523260
81	Chronic bronchitis (HP:0004469)	1.71666407
82	Bronchiectasis (HP:0002110)	1.71269359
83	Abolished electroretinogram (ERG) (HP:0000550)	1.70606334
84	Urinary urgency (HP:0000012)	1.70205899
85	Thyroid-stimulating hormone excess (HP:0002925)	1.69967945
86	Attenuation of retinal blood vessels (HP:0007843)	1.69153784
87	Broad foot (HP:0001769)	1.68818305
88	Decreased central vision (HP:0007663)	1.68676933
89	Amblyopia (HP:0000646)	1.66956826
90	Absence seizures (HP:0002121)	1.65577623
91	Dyskinesia (HP:0100660)	1.63978009
92	Concave nail (HP:0001598)	1.63910470
93	Excessive salivation (HP:0003781)	1.62944919
94	Pendular nystagmus (HP:0012043)	1.62671837
95	Gaze-evoked nystagmus (HP:0000640)	1.61145186
96	Progressive macrocephaly (HP:0004481)	1.61005201
97	Failure to thrive in infancy (HP:0001531)	1.57825880
98	Tubulointerstitial nephritis (HP:0001970)	1.57608748
99	Mitochondrial inheritance (HP:0001427)	1.57258061
100	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.56851683

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	3.77980370
2	MARK1	3.14037987
3	CASK	3.08327895
4	MAP2K7	3.02027996
5	MAP3K4	2.70721405
6	EPHA4	2.64779120
7	FRK	2.31804668
8	MAP4K2	2.18937973
9	MAPK15	2.16047879
10	MAPK13	2.11313745
11	GRK1	2.07342495
12	PRKD3	1.99365502
13	PAK6	1.98523100
14	NTRK3	1.91542760
15	WNK3	1.87798753
16	CSNK1G2	1.86028754
17	CSNK1G3	1.83416754
18	BCR	1.81625203
19	NTRK2	1.76343640
20	TLK1	1.75535287
21	TRIM28	1.75149593
22	CSNK1A1L	1.72850128
23	BMPR1B	1.72027113
24	DAPK2	1.67739931
25	ADRBK2	1.66314020
26	DYRK2	1.66177085
27	SIK2	1.53913750
28	MINK1	1.46288058
29	CSNK1G1	1.45944375
30	PLK2	1.45453157
31	PAK3	1.33644868
32	PRKCG	1.32810041
33	WNK4	1.29590496
34	STK16	1.20255008
35	LIMK1	1.19256876
36	ZAK	1.17693533
37	INSRR	1.14668584
38	PHKG2	1.12830532
39	PHKG1	1.12830532
40	TNIK	1.08307224
41	CAMKK2	1.07952463
42	UHMK1	1.06552338
43	NTRK1	1.05520717
44	PNCK	1.02830381
45	CDK5	0.99922208
46	CAMKK1	0.99912817
47	BCKDK	0.96551523
48	PRKCE	0.94955587
49	STK39	0.92676530
50	MAP2K4	0.88636200
51	MAP3K9	0.86711562
52	SGK223	0.86019171
53	SGK494	0.86019171
54	CAMK1	0.85381757
55	FGFR2	0.84328854
56	ADRBK1	0.79876226
57	CAMK2A	0.79233370
58	ERBB3	0.75559910
59	GRK5	0.74365457
60	STK38L	0.70260247
61	PKN1	0.69815860
62	OXSR1	0.68331259
63	LMTK2	0.64529625
64	CAMK2B	0.61642201
65	CDK14	0.61448822
66	RPS6KA5	0.59762575
67	CDK3	0.58005641
68	STK38	0.57413039
69	EPHB2	0.56774000
70	EPHA3	0.53444279
71	NUAK1	0.53395804
72	MUSK	0.52773365
73	VRK1	0.52688742
74	PRKCZ	0.52549271
75	DYRK1A	0.51748082
76	DYRK3	0.51574901
77	STK11	0.47754996
78	CSNK1D	0.46048263
79	PRKCH	0.45440499
80	CSNK1A1	0.45169860
81	PRKACA	0.44837327
82	PTK2B	0.43979980
83	ARAF	0.43325046
84	SGK2	0.43191167
85	CDK18	0.42856013
86	MAPKAPK5	0.41606371
87	PRKCI	0.39887351
88	CDK15	0.39825406
89	CAMK2G	0.39703762
90	TESK1	0.37935242
91	BRSK1	0.36255163
92	SRPK1	0.34019336
93	PLK1	0.33342303
94	CAMK4	0.32729966
95	CDK11A	0.32455759
96	TGFBR1	0.31295315
97	AURKA	0.31172302
98	CAMK2D	0.30399373
99	DYRK1B	0.29612570
100	KSR1	0.29417672

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.73554174
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.85254530
3	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.39057483
4	Phototransduction_Homo sapiens_hsa04744	2.35420313
5	GABAergic synapse_Homo sapiens_hsa04727	2.33452715
6	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.33215498
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.21759223
8	Morphine addiction_Homo sapiens_hsa05032	2.12614375
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.08680090
10	Circadian entrainment_Homo sapiens_hsa04713	2.06688971
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.06498107
12	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.02202557
13	Glutamatergic synapse_Homo sapiens_hsa04724	1.89477276
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.83858457
15	Butanoate metabolism_Homo sapiens_hsa00650	1.81758112
16	Protein export_Homo sapiens_hsa03060	1.80111675
17	Parkinsons disease_Homo sapiens_hsa05012	1.69725490
18	Insulin secretion_Homo sapiens_hsa04911	1.65882076
19	Cocaine addiction_Homo sapiens_hsa05030	1.65137359
20	Dopaminergic synapse_Homo sapiens_hsa04728	1.62737636
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.59338096
22	Amphetamine addiction_Homo sapiens_hsa05031	1.54586643
23	Taste transduction_Homo sapiens_hsa04742	1.53255096
24	Huntingtons disease_Homo sapiens_hsa05016	1.51487725
25	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.48005010
26	Collecting duct acid secretion_Homo sapiens_hsa04966	1.45639765
27	Olfactory transduction_Homo sapiens_hsa04740	1.44645005
28	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.43972125
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.38974476
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.35372550
31	Alzheimers disease_Homo sapiens_hsa05010	1.24140175
32	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.22870258
33	beta-Alanine metabolism_Homo sapiens_hsa00410	1.19798382
34	Gastric acid secretion_Homo sapiens_hsa04971	1.19059464
35	RNA polymerase_Homo sapiens_hsa03020	1.18435697
36	Serotonergic synapse_Homo sapiens_hsa04726	1.14066730
37	Axon guidance_Homo sapiens_hsa04360	1.12952853
38	Cholinergic synapse_Homo sapiens_hsa04725	1.11164195
39	Salivary secretion_Homo sapiens_hsa04970	1.10651850
40	Basal transcription factors_Homo sapiens_hsa03022	1.10595717
41	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.06341732
42	Linoleic acid metabolism_Homo sapiens_hsa00591	1.06220545
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.06011766
44	Nitrogen metabolism_Homo sapiens_hsa00910	1.05904309
45	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.02567924
46	Selenocompound metabolism_Homo sapiens_hsa00450	1.01644989
47	Fanconi anemia pathway_Homo sapiens_hsa03460	1.00605916
48	Regulation of autophagy_Homo sapiens_hsa04140	0.98011056
49	Calcium signaling pathway_Homo sapiens_hsa04020	0.93533579
50	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.93204023
51	Gap junction_Homo sapiens_hsa04540	0.92141889
52	Peroxisome_Homo sapiens_hsa04146	0.88924732
53	Long-term depression_Homo sapiens_hsa04730	0.88239067
54	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.84489662
55	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.83870878
56	Basal cell carcinoma_Homo sapiens_hsa05217	0.83142770
57	Hippo signaling pathway_Homo sapiens_hsa04390	0.82945452
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.81501213
59	cAMP signaling pathway_Homo sapiens_hsa04024	0.74545012
60	Alcoholism_Homo sapiens_hsa05034	0.74397887
61	Vibrio cholerae infection_Homo sapiens_hsa05110	0.73629657
62	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.72630971
63	Propanoate metabolism_Homo sapiens_hsa00640	0.72202512
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.71859277
65	Tryptophan metabolism_Homo sapiens_hsa00380	0.70902555
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.70350677
67	Sulfur relay system_Homo sapiens_hsa04122	0.70283199
68	Melanogenesis_Homo sapiens_hsa04916	0.69770696
69	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.69348064
70	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.68150207
71	Circadian rhythm_Homo sapiens_hsa04710	0.67620256
72	Renin secretion_Homo sapiens_hsa04924	0.67595207
73	RNA degradation_Homo sapiens_hsa03018	0.66336017
74	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.61122903
75	Purine metabolism_Homo sapiens_hsa00230	0.56716148
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55729768
77	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.54238967
78	Homologous recombination_Homo sapiens_hsa03440	0.54018958
79	Chemical carcinogenesis_Homo sapiens_hsa05204	0.53367797
80	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.52379150
81	Oocyte meiosis_Homo sapiens_hsa04114	0.52051831
82	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.51233747
83	Metabolic pathways_Homo sapiens_hsa01100	0.50684887
84	Wnt signaling pathway_Homo sapiens_hsa04310	0.49723775
85	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48765030
86	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.45892572
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45721194
88	Histidine metabolism_Homo sapiens_hsa00340	0.45186096
89	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.44364654
90	Long-term potentiation_Homo sapiens_hsa04720	0.44336957
91	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.43004887
92	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.41187877
93	Sphingolipid metabolism_Homo sapiens_hsa00600	0.38241415
94	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.38022211
95	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.37409091
96	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.34733474
97	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.34706602
98	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.34380032
99	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.33806812
100	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.32968003

LINC00094

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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