ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.35666039
2	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	6.30272307
3	respiratory electron transport chain (GO:0022904)	5.86349761
4	protein complex biogenesis (GO:0070271)	5.76765871
5	electron transport chain (GO:0022900)	5.76265186
6	ATP synthesis coupled proton transport (GO:0015986)	5.75251870
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.75251870
8	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.24839437
9	NADH dehydrogenase complex assembly (GO:0010257)	5.24839437
10	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.24839437
11	mitochondrial respiratory chain complex assembly (GO:0033108)	5.23942852
12	muscle filament sliding (GO:0030049)	4.99856670
13	actin-myosin filament sliding (GO:0033275)	4.99856670
14	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.79875119
15	respiratory chain complex IV assembly (GO:0008535)	4.60642359
16	cytochrome complex assembly (GO:0017004)	4.47046284
17	proteasome assembly (GO:0043248)	4.42855887
18	regulation of skeletal muscle contraction (GO:0014819)	4.36488347
19	chaperone-mediated protein transport (GO:0072321)	4.32457683
20	DNA deamination (GO:0045006)	4.17168310
21	actin-mediated cell contraction (GO:0070252)	4.00692245
22	sarcoplasmic reticulum calcium ion transport (GO:0070296)	3.92164520
23	hydrogen ion transmembrane transport (GO:1902600)	3.91316047
24	cytidine deamination (GO:0009972)	3.89096034
25	cytidine metabolic process (GO:0046087)	3.89096034
26	cytidine catabolic process (GO:0006216)	3.89096034
27	regulation of mitochondrial translation (GO:0070129)	3.87284151
28	protein neddylation (GO:0045116)	3.71216059
29	ATP biosynthetic process (GO:0006754)	3.67913167
30	ubiquinone biosynthetic process (GO:0006744)	3.66454062
31	proton transport (GO:0015992)	3.64851444
32	skeletal muscle contraction (GO:0003009)	3.63546196
33	hydrogen transport (GO:0006818)	3.59284072
34	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.55681980
35	response to muscle activity (GO:0014850)	3.54641448
36	regulation of relaxation of muscle (GO:1901077)	3.52535141
37	oxidative phosphorylation (GO:0006119)	3.49050868
38	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.45385343
39	protein targeting to mitochondrion (GO:0006626)	3.44883782
40	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.43325806
41	regulation of cellular amino acid metabolic process (GO:0006521)	3.32426700
42	establishment of protein localization to mitochondrion (GO:0072655)	3.26425089
43	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	3.25724068
44	mitochondrial transport (GO:0006839)	3.20779097
45	water-soluble vitamin biosynthetic process (GO:0042364)	3.20089975
46	inner mitochondrial membrane organization (GO:0007007)	3.18108254
47	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	3.15028213
48	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.13159794
49	AMP metabolic process (GO:0046033)	3.13121693
50	ubiquinone metabolic process (GO:0006743)	3.13070408
51	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.12861683
52	termination of RNA polymerase III transcription (GO:0006386)	3.12861683
53	protein localization to mitochondrion (GO:0070585)	3.11667330
54	intracellular protein transmembrane import (GO:0044743)	3.11040820
55	platelet dense granule organization (GO:0060155)	3.10114994
56	peptidyl-histidine modification (GO:0018202)	3.09626580
57	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.07977454
58	regulation of oxidative phosphorylation (GO:0002082)	3.06403927
59	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.99287545
60	regulation of hexokinase activity (GO:1903299)	2.97628815
61	regulation of glucokinase activity (GO:0033131)	2.97628815
62	quinone biosynthetic process (GO:1901663)	2.96291970
63	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.95900110
64	metallo-sulfur cluster assembly (GO:0031163)	2.95357419
65	iron-sulfur cluster assembly (GO:0016226)	2.95357419
66	regulation of cellular respiration (GO:0043457)	2.95156543
67	rRNA modification (GO:0000154)	2.95133950
68	purine nucleotide salvage (GO:0032261)	2.94160521
69	aerobic respiration (GO:0009060)	2.93358180
70	cellular response to zinc ion (GO:0071294)	2.92580711
71	cullin deneddylation (GO:0010388)	2.88858890
72	cellular ketone body metabolic process (GO:0046950)	2.85799301
73	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.85484249
74	mannosylation (GO:0097502)	2.85089305
75	nucleoside triphosphate biosynthetic process (GO:0009142)	2.83355801
76	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.82096336
77	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.82096336
78	protein deneddylation (GO:0000338)	2.79593397
79	mitochondrial calcium ion homeostasis (GO:0051560)	2.79094722
80	pseudouridine synthesis (GO:0001522)	2.79094326
81	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.78248829
82	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.75072167
83	NADH metabolic process (GO:0006734)	2.71354653
84	cellular respiration (GO:0045333)	2.71248731
85	negative regulation of ligase activity (GO:0051352)	2.69641131
86	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.69641131
87	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.65913774
88	GTP biosynthetic process (GO:0006183)	2.65465832
89	heart process (GO:0003015)	2.65279418
90	heart contraction (GO:0060047)	2.65279418
91	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.64699776
92	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.64432935
93	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.64432935
94	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.63671309
95	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.63671309
96	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.63671309
97	skeletal muscle fiber development (GO:0048741)	2.62754643
98	tricarboxylic acid cycle (GO:0006099)	2.61719222
99	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.61397800
100	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	2.61190386

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.28447881
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.86846896
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.78950268
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.15880963
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.97633768
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.88772580
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.83048462
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.76289224
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.31479223
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.28804895
11	SRF_21415370_ChIP-Seq_HL-1_Mouse	3.16996511
12	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.85044280
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.42549441
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.37404956
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.28674128
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.23054172
17	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.05595411
18	FOXP3_21729870_ChIP-Seq_TREG_Human	1.99483124
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.92816533
20	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.88427514
21	ZNF274_21170338_ChIP-Seq_K562_Hela	1.88039558
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.84796852
23	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.81833349
24	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.79126397
25	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.78116648
26	VDR_22108803_ChIP-Seq_LS180_Human	1.75372238
27	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.70542250
28	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.69087199
29	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.66966827
30	DCP1A_22483619_ChIP-Seq_HELA_Human	1.65567261
31	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.58221497
32	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.50492179
33	GABP_19822575_ChIP-Seq_HepG2_Human	1.48856004
34	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.48292833
35	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.44197522
36	HTT_18923047_ChIP-ChIP_STHdh_Human	1.43108730
37	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.42457515
38	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.42353498
39	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.41490151
40	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.39922066
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.35545262
42	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.32871488
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30961305
44	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.27986892
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.27597923
46	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.26642711
47	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.22351361
48	IGF1R_20145208_ChIP-Seq_DFB_Human	1.22285436
49	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.20428927
50	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.15900092
51	AR_20517297_ChIP-Seq_VCAP_Human	1.14396073
52	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.11504928
53	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.11126430
54	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.09637013
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07711193
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07711193
57	NANOG_20526341_ChIP-Seq_ESCs_Human	1.07588469
58	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.06935241
59	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.06172358
60	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	1.05301768
61	TTF2_22483619_ChIP-Seq_HELA_Human	1.03584149
62	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.02465025
63	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.02013927
64	ERG_20517297_ChIP-Seq_VCAP_Human	0.99128565
65	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.97330517
66	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.97330517
67	NCOR_22424771_ChIP-Seq_293T_Human	0.96635293
68	XRN2_22483619_ChIP-Seq_HELA_Human	0.94951680
69	STAT1_20625510_ChIP-Seq_HELA_Human	0.94765202
70	MYC_19829295_ChIP-Seq_ESCs_Human	0.94520955
71	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.93196395
72	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.92195661
73	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.91716142
74	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.88061757
75	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.86659261
76	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.86244182
77	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.85466563
78	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.85065928
79	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.84909846
80	TAF2_19829295_ChIP-Seq_ESCs_Human	0.84386418
81	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.83956252
82	PHF8_20622853_ChIP-Seq_HELA_Human	0.83930559
83	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.83850741
84	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.82509612
85	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.82391161
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.81959858
87	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.80706860
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.80348920
89	ER_23166858_ChIP-Seq_MCF-7_Human	0.79427309
90	OCT4_20526341_ChIP-Seq_ESCs_Human	0.79228133
91	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.78292318
92	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.76627044
93	RBPJ_21746931_ChIP-Seq_IB4_Human	0.76112881
94	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.75297789
95	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.75200670
96	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.74050882
97	ERA_21632823_ChIP-Seq_H3396_Human	0.73943709
98	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.73412642
99	P53_21459846_ChIP-Seq_SAOS-2_Human	0.73314971
100	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.72730597

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	4.88595953
2	MP0002837_dystrophic_cardiac_calcinosis	4.45307013
3	MP0004145_abnormal_muscle_electrophysio	4.19511489
4	MP0000749_muscle_degeneration	4.04313141
5	MP0003806_abnormal_nucleotide_metabolis	3.88596444
6	MP0006036_abnormal_mitochondrial_physio	3.50463904
7	MP0000372_irregular_coat_pigmentation	2.74658946
8	MP0000751_myopathy	2.62756123
9	MP0004036_abnormal_muscle_relaxation	2.53986349
10	MP0002638_abnormal_pupillary_reflex	2.31366719
11	MP0005330_cardiomyopathy	2.07806528
12	MP0003186_abnormal_redox_activity	2.05278327
13	MP0002106_abnormal_muscle_physiology	1.98967490
14	MP0003011_delayed_dark_adaptation	1.97606304
15	MP0002163_abnormal_gland_morphology	1.88398295
16	MP0002332_abnormal_exercise_endurance	1.87908288
17	MP0002876_abnormal_thyroid_physiology	1.85434536
18	MP0005620_abnormal_muscle_contractility	1.81147997
19	MP0004215_abnormal_myocardial_fiber	1.79414516
20	MP0000750_abnormal_muscle_regeneration	1.74491847
21	MP0003195_calcinosis	1.69529890
22	MP0002269_muscular_atrophy	1.69461444
23	MP0005369_muscle_phenotype	1.68149506
24	MP0004084_abnormal_cardiac_muscle	1.65328294
25	MP0001905_abnormal_dopamine_level	1.64373132
26	MP0000759_abnormal_skeletal_muscle	1.61982131
27	MP0005379_endocrine/exocrine_gland_phen	1.59694450
28	MP0004142_abnormal_muscle_tone	1.58993654
29	MP0004147_increased_porphyrin_level	1.56419967
30	MP0005266_abnormal_metabolism	1.54307636
31	MP0005332_abnormal_amino_acid	1.46641005
32	MP0002972_abnormal_cardiac_muscle	1.43774223
33	MP0006035_abnormal_mitochondrial_morpho	1.43068469
34	MP0006072_abnormal_retinal_apoptosis	1.42415866
35	MP0004087_abnormal_muscle_fiber	1.40973996
36	MP0005645_abnormal_hypothalamus_physiol	1.40820336
37	MP0008875_abnormal_xenobiotic_pharmacok	1.38100223
38	MP0000747_muscle_weakness	1.37908238
39	MP0003786_premature_aging	1.36978935
40	MP0001764_abnormal_homeostasis	1.34951948
41	MP0005451_abnormal_body_composition	1.29363474
42	MP0009046_muscle_twitch	1.28237563
43	MP0003137_abnormal_impulse_conducting	1.27636380
44	MP0002277_abnormal_respiratory_mucosa	1.24479504
45	MP0001984_abnormal_olfaction	1.23962543
46	MP0010386_abnormal_urinary_bladder	1.23788802
47	MP0001529_abnormal_vocalization	1.22076969
48	MP0005075_abnormal_melanosome_morpholog	1.19907454
49	MP0002693_abnormal_pancreas_physiology	1.19362624
50	MP0005084_abnormal_gallbladder_morpholo	1.19204531
51	MP0001661_extended_life_span	1.15001642
52	MP0000013_abnormal_adipose_tissue	1.12328111
53	MP0005253_abnormal_eye_physiology	1.12217152
54	MP0005410_abnormal_fertilization	1.08596281
55	MP0008872_abnormal_physiological_respon	1.02606556
56	MP0001873_stomach_inflammation	1.01141101
57	MP0002822_catalepsy	1.00953598
58	MP0003950_abnormal_plasma_membrane	0.99150549
59	MP0009697_abnormal_copulation	0.97768263
60	MP0004484_altered_response_of	0.96638435
61	MP0005646_abnormal_pituitary_gland	0.96393786
62	MP0005636_abnormal_mineral_homeostasis	0.95228629
63	MP0008775_abnormal_heart_ventricle	0.94924112
64	MP0000343_altered_response_to	0.94106722
65	MP0009780_abnormal_chondrocyte_physiolo	0.93796931
66	MP0001544_abnormal_cardiovascular_syste	0.92300048
67	MP0005385_cardiovascular_system_phenoty	0.92300048
68	MP0002160_abnormal_reproductive_system	0.90663251
69	MP0004043_abnormal_pH_regulation	0.90633213
70	MP0004130_abnormal_muscle_cell	0.89477124
71	MP0005551_abnormal_eye_electrophysiolog	0.89028167
72	MP0002127_abnormal_cardiovascular_syste	0.88725470
73	MP0009745_abnormal_behavioral_response	0.86350697
74	MP0002078_abnormal_glucose_homeostasis	0.85887927
75	MP0004510_myositis	0.81111916
76	MP0002272_abnormal_nervous_system	0.80955854
77	MP0005670_abnormal_white_adipose	0.80776917
78	MP0005584_abnormal_enzyme/coenzyme_acti	0.79962814
79	MP0006276_abnormal_autonomic_nervous	0.78463567
80	MP0005535_abnormal_body_temperature	0.77383846
81	MP0002132_abnormal_respiratory_system	0.77288769
82	MP0005389_reproductive_system_phenotype	0.77226353
83	MP0004233_abnormal_muscle_weight	0.76767544
84	MP0002148_abnormal_hypersensitivity_rea	0.76593856
85	MP0002938_white_spotting	0.76497935
86	MP0002234_abnormal_pharynx_morphology	0.76368117
87	MP0002108_abnormal_muscle_morphology	0.75939874
88	MP0004085_abnormal_heartbeat	0.75387409
89	MP0009333_abnormal_splenocyte_physiolog	0.75209572
90	MP0008058_abnormal_DNA_repair	0.73925857
91	MP0003880_abnormal_central_pattern	0.73736400
92	MP0008995_early_reproductive_senescence	0.73065568
93	MP0005365_abnormal_bile_salt	0.72699301
94	MP0005319_abnormal_enzyme/_coenzyme	0.72093392
95	MP0001756_abnormal_urination	0.70588290
96	MP0001968_abnormal_touch/_nociception	0.70464027
97	MP0002102_abnormal_ear_morphology	0.70216535
98	MP0001944_abnormal_pancreas_morphology	0.69872997
99	MP0001542_abnormal_bone_strength	0.68108052
100	MP0010329_abnormal_lipoprotein_level	0.67757031

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Muscle fiber inclusion bodies (HP:0100299)	5.99262722
2	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	5.79730132
3	Nemaline bodies (HP:0003798)	5.77962640
4	Acute necrotizing encephalopathy (HP:0006965)	5.65343511
5	Abnormal mitochondria in muscle tissue (HP:0008316)	5.25852303
6	Mitochondrial inheritance (HP:0001427)	5.20292208
7	Progressive macrocephaly (HP:0004481)	4.86325862
8	Acute encephalopathy (HP:0006846)	4.79590015
9	Hepatocellular necrosis (HP:0001404)	4.65313385
10	Increased CSF lactate (HP:0002490)	4.53865663
11	Hepatic necrosis (HP:0002605)	4.47624111
12	Exercise-induced muscle cramps (HP:0003710)	4.33190530
13	Increased intramyocellular lipid droplets (HP:0012240)	3.96446157
14	Exercise-induced myalgia (HP:0003738)	3.95950139
15	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.89163320
16	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.89163320
17	Increased hepatocellular lipid droplets (HP:0006565)	3.84899838
18	Lipid accumulation in hepatocytes (HP:0006561)	3.82339231
19	Muscle hypertrophy of the lower extremities (HP:0008968)	3.71774761
20	Increased muscle lipid content (HP:0009058)	3.62978398
21	Cerebral edema (HP:0002181)	3.62793480
22	Rhabdomyolysis (HP:0003201)	3.59311460
23	Exercise intolerance (HP:0003546)	3.58389462
24	Type 1 muscle fiber predominance (HP:0003803)	3.48359553
25	Renal Fanconi syndrome (HP:0001994)	3.45343790
26	Calf muscle hypertrophy (HP:0008981)	3.41757896
27	Myoglobinuria (HP:0002913)	3.40619838
28	Distal arthrogryposis (HP:0005684)	3.36969074
29	Lactic acidosis (HP:0003128)	3.29242710
30	3-Methylglutaconic aciduria (HP:0003535)	3.28313900
31	Respiratory failure (HP:0002878)	3.26438962
32	EMG: myopathic abnormalities (HP:0003458)	3.14278604
33	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.05132471
34	Myopathic facies (HP:0002058)	2.97682683
35	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.96071997
36	Increased serum lactate (HP:0002151)	2.88182738
37	Rimmed vacuoles (HP:0003805)	2.86033564
38	Abnormality of the calf musculature (HP:0001430)	2.77813147
39	Exertional dyspnea (HP:0002875)	2.50145801
40	Optic disc pallor (HP:0000543)	2.49453188
41	Neck muscle weakness (HP:0000467)	2.49383487
42	Ketoacidosis (HP:0001993)	2.46383688
43	Dicarboxylic aciduria (HP:0003215)	2.44669678
44	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.44669678
45	Hyporeflexia of lower limbs (HP:0002600)	2.40751492
46	Lethargy (HP:0001254)	2.39836810
47	Muscle fiber splitting (HP:0003555)	2.30666733
48	CNS demyelination (HP:0007305)	2.26358096
49	Type I transferrin isoform profile (HP:0003642)	2.26149985
50	Round ear (HP:0100830)	2.24947416
51	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.19957315
52	Ketosis (HP:0001946)	2.19849531
53	Methylmalonic acidemia (HP:0002912)	2.17476516
54	Leukodystrophy (HP:0002415)	2.17376609
55	Abnormality of urine glucose concentration (HP:0011016)	2.15659162
56	Glycosuria (HP:0003076)	2.15659162
57	Generalized aminoaciduria (HP:0002909)	2.14922200
58	Muscle stiffness (HP:0003552)	2.14467389
59	Methylmalonic aciduria (HP:0012120)	2.12964572
60	Type 2 muscle fiber atrophy (HP:0003554)	2.09665039
61	Palpitations (HP:0001962)	2.09127365
62	Emotional lability (HP:0000712)	2.06194749
63	Hypothermia (HP:0002045)	2.02101971
64	Abnormality of renal resorption (HP:0011038)	1.98847664
65	Abnormality of fatty-acid metabolism (HP:0004359)	1.97027873
66	Muscle fiber atrophy (HP:0100295)	1.95830900
67	Ulnar deviation of the wrist (HP:0003049)	1.94947017
68	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.94667687
69	Absent phalangeal crease (HP:0006109)	1.93548490
70	Myotonia (HP:0002486)	1.91602997
71	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.90734312
72	Increased serum pyruvate (HP:0003542)	1.88973641
73	Hypoglycemic coma (HP:0001325)	1.88183426
74	X-linked dominant inheritance (HP:0001423)	1.86937624
75	Large for gestational age (HP:0001520)	1.85968803
76	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.85715174
77	Abnormal protein N-linked glycosylation (HP:0012347)	1.85715174
78	Abnormal protein glycosylation (HP:0012346)	1.85715174
79	Abnormal glycosylation (HP:0012345)	1.85715174
80	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.84676888
81	Reduced antithrombin III activity (HP:0001976)	1.84625015
82	Malignant hyperthermia (HP:0002047)	1.82048443
83	Respiratory difficulties (HP:0002880)	1.81988071
84	Areflexia of lower limbs (HP:0002522)	1.81698288
85	Abnormal pupillary function (HP:0007686)	1.80266217
86	Sudden death (HP:0001699)	1.79110051
87	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.78960192
88	Abnormality of alanine metabolism (HP:0010916)	1.78960192
89	Hyperalaninemia (HP:0003348)	1.78960192
90	Ragged-red muscle fibers (HP:0003200)	1.77940291
91	Hyperinsulinemic hypoglycemia (HP:0000825)	1.76435766
92	Aplastic anemia (HP:0001915)	1.75205911
93	Distal lower limb muscle weakness (HP:0009053)	1.75033924
94	Paralysis (HP:0003470)	1.74819164
95	Abnormality of placental membranes (HP:0011409)	1.74538665
96	Amniotic constriction ring (HP:0009775)	1.74538665
97	Frequent falls (HP:0002359)	1.71122854
98	Abnormal number of erythroid precursors (HP:0012131)	1.69604837
99	Abnormality of glycolysis (HP:0004366)	1.69104769
100	Abnormality of skeletal muscle fiber size (HP:0012084)	1.66163903

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	OBSCN	5.82065069
2	PHKG1	3.96229590
3	PHKG2	3.96229590
4	VRK2	3.84108172
5	PINK1	3.55715933
6	NME2	2.32823887
7	MAP4K2	2.32662264
8	BCKDK	2.27908017
9	MST4	2.26253797
10	MAPKAPK3	2.24076584
11	FRK	2.20834101
12	TXK	2.18530639
13	NME1	2.18389096
14	LIMK1	2.16225599
15	MAP3K12	1.69899854
16	VRK1	1.69337447
17	ZAK	1.62710641
18	TTN	1.61779467
19	BMPR1B	1.56535740
20	ADRBK2	1.54907654
21	GRK1	1.47374907
22	MUSK	1.44407189
23	MYLK	1.43585737
24	NUAK1	1.39319816
25	BUB1	1.38066937
26	NEK1	1.36504793
27	STK16	1.36415697
28	INSRR	1.35192657
29	PDK2	1.32749831
30	PIM2	1.25045145
31	TESK1	1.17401172
32	TLK1	1.14468729
33	KDR	1.09804818
34	TIE1	1.06369588
35	PIK3CG	1.04438549
36	ABL2	0.99160204
37	ARAF	0.98642435
38	MAP2K6	0.93079399
39	PBK	0.91629134
40	CCNB1	0.91436572
41	CSNK1G3	0.91435783
42	CSNK1G1	0.90671431
43	DAPK1	0.90272372
44	EIF2AK3	0.88081532
45	MAP2K7	0.87688566
46	WNK3	0.86473672
47	ILK	0.85296353
48	DAPK3	0.81289906
49	MAP3K11	0.78579428
50	EIF2AK1	0.77739935
51	CAMK2D	0.77728302
52	TESK2	0.77550421
53	CAMK2G	0.77012743
54	GRK5	0.76110656
55	MAPK13	0.71443976
56	CSNK1G2	0.70057843
57	ERBB3	0.69735430
58	MAPK12	0.67400653
59	GRK7	0.64398045
60	RPS6KA5	0.64044810
61	DYRK2	0.61313329
62	SRPK1	0.59590757
63	IKBKB	0.56699984
64	MARK3	0.55359540
65	DAPK2	0.54896262
66	CAMK2A	0.53845712
67	PRKACA	0.53340599
68	TRIM28	0.49722038
69	CSNK1A1L	0.49268702
70	PRKG1	0.47659346
71	TNK2	0.45495744
72	PAK1	0.45077458
73	PAK3	0.44321798
74	PRKCE	0.43658352
75	AURKA	0.43617994
76	ADRBK1	0.43243926
77	AKT2	0.42937749
78	PRKCQ	0.42708609
79	CSNK1A1	0.42051039
80	CAMK1	0.41335192
81	PRKCI	0.38501026
82	TAOK3	0.37794639
83	CSNK2A2	0.37693273
84	PKN1	0.35873344
85	ROCK1	0.35791592
86	PRKG2	0.34471269
87	CSNK2A1	0.34461712
88	BRAF	0.32984217
89	PRKCA	0.32756695
90	PLK3	0.30505054
91	PRKAA1	0.29678658
92	PRKACB	0.28255091
93	PRKCG	0.27797560
94	PLK1	0.25647292
95	TBK1	0.25363632
96	TEC	0.24782080
97	PLK2	0.23644289
98	MOS	0.23101938
99	PTK2B	0.22540672
100	CAMKK2	0.21846302

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	5.18247404
2	Parkinsons disease_Homo sapiens_hsa05012	4.39920397
3	Proteasome_Homo sapiens_hsa03050	3.71976696
4	Alzheimers disease_Homo sapiens_hsa05010	3.09384521
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.96882280
6	Ribosome_Homo sapiens_hsa03010	2.89469642
7	Huntingtons disease_Homo sapiens_hsa05016	2.79963346
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.77406696
9	Protein export_Homo sapiens_hsa03060	2.42516297
10	RNA polymerase_Homo sapiens_hsa03020	2.33874908
11	Fatty acid elongation_Homo sapiens_hsa00062	2.02718006
12	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.76730675
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.73896170
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.73302842
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.68051741
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.58342057
17	Folate biosynthesis_Homo sapiens_hsa00790	1.56046547
18	Butanoate metabolism_Homo sapiens_hsa00650	1.54767392
19	Sulfur metabolism_Homo sapiens_hsa00920	1.54010203
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.53415332
21	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.52658925
22	Sulfur relay system_Homo sapiens_hsa04122	1.44610494
23	Propanoate metabolism_Homo sapiens_hsa00640	1.43526778
24	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.42633244
25	Peroxisome_Homo sapiens_hsa04146	1.41519921
26	Glutathione metabolism_Homo sapiens_hsa00480	1.33360143
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.32702225
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.29631923
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.24679395
30	Pyruvate metabolism_Homo sapiens_hsa00620	1.24626875
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.14768833
32	Purine metabolism_Homo sapiens_hsa00230	1.08769159
33	Carbon metabolism_Homo sapiens_hsa01200	1.08035423
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.02380777
35	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.99064554
36	Homologous recombination_Homo sapiens_hsa03440	0.97405377
37	Metabolic pathways_Homo sapiens_hsa01100	0.97052670
38	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.94415229
39	Regulation of autophagy_Homo sapiens_hsa04140	0.92084976
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.90718274
41	Arginine and proline metabolism_Homo sapiens_hsa00330	0.88898346
42	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.87559356
43	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.87216468
44	Tryptophan metabolism_Homo sapiens_hsa00380	0.86784990
45	Basal transcription factors_Homo sapiens_hsa03022	0.85395253
46	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.85226136
47	Fatty acid degradation_Homo sapiens_hsa00071	0.84184726
48	RNA degradation_Homo sapiens_hsa03018	0.79888904
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.79422919
50	Pentose phosphate pathway_Homo sapiens_hsa00030	0.79086864
51	Circadian rhythm_Homo sapiens_hsa04710	0.78344247
52	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.77383657
53	One carbon pool by folate_Homo sapiens_hsa00670	0.77167420
54	beta-Alanine metabolism_Homo sapiens_hsa00410	0.75460728
55	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.72825849
56	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.72251067
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70007925
58	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.68926386
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68570390
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68378463
61	Tyrosine metabolism_Homo sapiens_hsa00350	0.68350668
62	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.65486673
63	Rheumatoid arthritis_Homo sapiens_hsa05323	0.65376666
64	Phototransduction_Homo sapiens_hsa04744	0.65030290
65	Mismatch repair_Homo sapiens_hsa03430	0.64898630
66	Fatty acid metabolism_Homo sapiens_hsa01212	0.63128869
67	Phenylalanine metabolism_Homo sapiens_hsa00360	0.63006577
68	Arginine biosynthesis_Homo sapiens_hsa00220	0.57398162
69	Selenocompound metabolism_Homo sapiens_hsa00450	0.56031953
70	Base excision repair_Homo sapiens_hsa03410	0.55127688
71	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.53245222
72	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.51522778
73	DNA replication_Homo sapiens_hsa03030	0.49434120
74	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.48499045
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47370418
76	Fanconi anemia pathway_Homo sapiens_hsa03460	0.46184780
77	Linoleic acid metabolism_Homo sapiens_hsa00591	0.42695097
78	Glucagon signaling pathway_Homo sapiens_hsa04922	0.42417779
79	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.41985880
80	Mineral absorption_Homo sapiens_hsa04978	0.40814518
81	Type I diabetes mellitus_Homo sapiens_hsa04940	0.40205529
82	Primary immunodeficiency_Homo sapiens_hsa05340	0.40044296
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39426979
84	Galactose metabolism_Homo sapiens_hsa00052	0.38401114
85	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.37802340
86	Retinol metabolism_Homo sapiens_hsa00830	0.37663288
87	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.36912132
88	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.36354582
89	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.34648192
90	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.33529041
91	Calcium signaling pathway_Homo sapiens_hsa04020	0.32950820
92	Olfactory transduction_Homo sapiens_hsa04740	0.31090437
93	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.30148896
94	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.29974102
95	Insulin secretion_Homo sapiens_hsa04911	0.29149040
96	Vibrio cholerae infection_Homo sapiens_hsa05110	0.28589142
97	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.28143523
98	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.27275053
99	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.26725318
100	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.26313253

LINC00116

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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