ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of protein kinase C signaling (GO:0090037)	5.31682201
2	cellular response to interleukin-15 (GO:0071350)	5.18732318
3	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	5.04416870
4	response to interleukin-15 (GO:0070672)	4.89391708
5	GDP-mannose metabolic process (GO:0019673)	4.43895557
6	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	4.39368211
7	B cell receptor signaling pathway (GO:0050853)	4.26084993
8	protein carboxylation (GO:0018214)	4.19510098
9	peptidyl-glutamic acid carboxylation (GO:0017187)	4.19510098
10	B cell homeostasis (GO:0001782)	4.18227606
11	thymic T cell selection (GO:0045061)	3.93715159
12	negative regulation of cell killing (GO:0031342)	3.89062803
13	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	3.89062803
14	positive thymic T cell selection (GO:0045059)	3.84272377
15	very-low-density lipoprotein particle assembly (GO:0034379)	3.82994781
16	proline biosynthetic process (GO:0006561)	3.82868006
17	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	3.80048900
18	T-helper 1 type immune response (GO:0042088)	3.79814023
19	regulation of cholesterol homeostasis (GO:2000188)	3.79156775
20	negative thymic T cell selection (GO:0045060)	3.76962184
21	proline metabolic process (GO:0006560)	3.70855454
22	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	3.70779614
23	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	3.70253107
24	positive regulation of humoral immune response (GO:0002922)	3.68504404
25	negative regulation of myeloid cell apoptotic process (GO:0033033)	3.67962837
26	positive regulation of interferon-gamma biosynthetic process (GO:0045078)	3.67334851
27	plasma lipoprotein particle assembly (GO:0034377)	3.65949129
28	response to muramyl dipeptide (GO:0032495)	3.64109659
29	positive regulation of gamma-delta T cell activation (GO:0046645)	3.63028626
30	T cell lineage commitment (GO:0002360)	3.62345026
31	myeloid dendritic cell differentiation (GO:0043011)	3.60006936
32	negative T cell selection (GO:0043383)	3.57750164
33	regulation of B cell receptor signaling pathway (GO:0050855)	3.52478759
34	antigen processing and presentation of endogenous antigen (GO:0019883)	3.48968432
35	low-density lipoprotein particle clearance (GO:0034383)	3.47697466
36	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.34802388
37	B cell proliferation (GO:0042100)	3.25872743
38	regulation of interferon-gamma biosynthetic process (GO:0045072)	3.24201401
39	intestinal cholesterol absorption (GO:0030299)	3.18145831
40	DNA strand renaturation (GO:0000733)	3.17366256
41	activation of MAPKKK activity (GO:0000185)	3.14179251
42	immunoglobulin mediated immune response (GO:0016064)	3.13520022
43	protein-lipid complex assembly (GO:0065005)	3.10395109
44	interferon-gamma production (GO:0032609)	3.10137480
45	T cell costimulation (GO:0031295)	3.07887148
46	myeloid dendritic cell activation (GO:0001773)	3.06887321
47	mannose metabolic process (GO:0006013)	3.06383045
48	plasma lipoprotein particle clearance (GO:0034381)	3.04213557
49	lymphocyte costimulation (GO:0031294)	3.02323281
50	regulation of type I interferon-mediated signaling pathway (GO:0060338)	3.01973020
51	tolerance induction (GO:0002507)	3.00255240
52	cellular response to ATP (GO:0071318)	3.00205948
53	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	3.00085509
54	regulation of T cell mediated cytotoxicity (GO:0001914)	2.99614858
55	regulation of gamma-delta T cell activation (GO:0046643)	2.96992336
56	regulation of defense response to virus by host (GO:0050691)	2.95004868
57	diacylglycerol metabolic process (GO:0046339)	2.94922297
58	plasma lipoprotein particle organization (GO:0071827)	2.94033357
59	high-density lipoprotein particle remodeling (GO:0034375)	2.93372095
60	germinal center formation (GO:0002467)	2.93350837
61	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.92405747
62	trivalent inorganic anion homeostasis (GO:0072506)	2.91858946
63	phosphate ion homeostasis (GO:0055062)	2.91858946
64	regulation of protein kinase C signaling (GO:0090036)	2.90072613
65	positive regulation of defense response to virus by host (GO:0002230)	2.89964897
66	cellular response to virus (GO:0098586)	2.89785512
67	response to type I interferon (GO:0034340)	2.86847054
68	negative regulation of viral release from host cell (GO:1902187)	2.85127364
69	lung epithelium development (GO:0060428)	2.84969163
70	low-density lipoprotein particle remodeling (GO:0034374)	2.84548246
71	negative regulation of T cell mediated immunity (GO:0002710)	2.83983203
72	cellular zinc ion homeostasis (GO:0006882)	2.83114562
73	plasma lipoprotein particle remodeling (GO:0034369)	2.82825551
74	protein-lipid complex remodeling (GO:0034368)	2.82825551
75	macromolecular complex remodeling (GO:0034367)	2.82825551
76	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)	2.82323928
77	tumor necrosis factor-mediated signaling pathway (GO:0033209)	2.81701159
78	positive regulation of B cell proliferation (GO:0030890)	2.81290016
79	regulation of B cell proliferation (GO:0030888)	2.79305708
80	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	2.77471875
81	positive T cell selection (GO:0043368)	2.77449533
82	regulation of monocyte differentiation (GO:0045655)	2.76570274
83	T cell migration (GO:0072678)	2.76317026
84	oligosaccharide catabolic process (GO:0009313)	2.76073747
85	reverse cholesterol transport (GO:0043691)	2.75267744
86	negative regulation of fibrinolysis (GO:0051918)	2.73193257
87	lymphocyte homeostasis (GO:0002260)	2.71700833
88	regulation of alpha-beta T cell proliferation (GO:0046640)	2.70079486
89	purine ribonucleotide transport (GO:0015868)	2.68450411
90	protein-lipid complex subunit organization (GO:0071825)	2.68089696
91	T cell selection (GO:0045058)	2.66104461
92	type I interferon signaling pathway (GO:0060337)	2.65805996
93	cellular response to type I interferon (GO:0071357)	2.65805996
94	production of molecular mediator of immune response (GO:0002440)	2.64737224
95	DNA deamination (GO:0045006)	2.60792724
96	negative regulation of innate immune response (GO:0045824)	2.60052111
97	histone H3-K36 demethylation (GO:0070544)	2.58115833
98	cytidine metabolic process (GO:0046087)	2.55731192
99	cytidine catabolic process (GO:0006216)	2.55731192
100	cytidine deamination (GO:0009972)	2.55731192

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYC_22102868_ChIP-Seq_BL_Human	3.63662188
2	VDR_21846776_ChIP-Seq_THP-1_Human	3.59796508
3	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	3.35333149
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.33186608
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.90211245
6	LXR_22292898_ChIP-Seq_THP-1_Human	2.83143369
7	MAF_26560356_Chip-Seq_TH1_Human	2.50587990
8	MAF_26560356_Chip-Seq_TH2_Human	2.37820161
9	P68_20966046_ChIP-Seq_HELA_Human	2.32171093
10	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	2.24160962
11	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.16622397
12	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	2.14393563
13	TCF7_22412390_ChIP-Seq_EML_Mouse	2.06037563
14	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.03658755
15	UTX_26944678_Chip-Seq_JUKART_Human	1.97043963
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.94936452
17	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.92218553
18	ZNF263_19887448_ChIP-Seq_K562_Human	1.91442418
19	KDM2B_26808549_Chip-Seq_DND41_Human	1.88627475
20	CIITA_25753668_ChIP-Seq_RAJI_Human	1.88109679
21	VDR_24763502_ChIP-Seq_THP-1_Human	1.87519870
22	BCL6_27268052_Chip-Seq_Bcells_Human	1.85247322
23	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.82940715
24	BCOR_27268052_Chip-Seq_Bcells_Human	1.82283774
25	RACK7_27058665_Chip-Seq_MCF-7_Human	1.80289587
26	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.76337737
27	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.73216373
28	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.71151012
29	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.69806590
30	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.64098053
31	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.60394872
32	SMC4_20622854_ChIP-Seq_HELA_Human	1.58717723
33	E2F1_20622854_ChIP-Seq_HELA_Human	1.57237925
34	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.56709549
35	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.55226371
36	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.50877931
37	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.50328397
38	TP53_22127205_ChIP-Seq_IMR90_Human	1.48838899
39	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.48728428
40	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.47348044
41	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.46432066
42	PHF8_20622854_ChIP-Seq_HELA_Human	1.46112409
43	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.45969418
44	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.44685018
45	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.42824014
46	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.42796168
47	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.42558231
48	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.39008503
49	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.38968199
50	MYB_26560356_Chip-Seq_TH1_Human	1.38509740
51	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.38320030
52	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.37541077
53	XRN2_22483619_ChIP-Seq_HELA_Human	1.36520000
54	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.34865162
55	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.34533393
56	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.30591363
57	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.30325222
58	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.30075763
59	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.29891509
60	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.29701789
61	CREB1_26743006_Chip-Seq_LNCaP_Human	1.25694329
62	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.25463240
63	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.24446903
64	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.23744151
65	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.23193701
66	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.23190525
67	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22487988
68	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.21730868
69	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.19837014
70	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.19004257
71	CTCF_27219007_Chip-Seq_Bcells_Human	1.18864204
72	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.18245204
73	NCOR1_26117541_ChIP-Seq_K562_Human	1.18131172
74	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.17831352
75	CTCF_21964334_Chip-Seq_Bcells_Human	1.16736348
76	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.16710539
77	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.15373420
78	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.14961514
79	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.14883549
80	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.13867907
81	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.13447100
82	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.12893289
83	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.12449002
84	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.11089720
85	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.10885717
86	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.09662209
87	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.08990781
88	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.08075477
89	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.07215419
90	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.06983640
91	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.06674001
92	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.05651631
93	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.05627513
94	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.05596933
95	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.05437744
96	ATF3_27146783_Chip-Seq_COLON_Human	1.05188842
97	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.04399810
98	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.04260687
99	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.02547537
100	P300_27268052_Chip-Seq_Bcells_Human	1.02209726

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000685_abnormal_immune_system	4.65949629
2	MP0005671_abnormal_response_to	3.97513917
3	MP0005645_abnormal_hypothalamus_physiol	3.62674649
4	MP0003763_abnormal_thymus_physiology	3.05478597
5	MP0004381_abnormal_hair_follicle	3.03439681
6	MP0001800_abnormal_humoral_immune	2.68071673
7	MP0001790_abnormal_immune_system	2.60104116
8	MP0005387_immune_system_phenotype	2.60104116
9	MP0005360_urolithiasis	2.58501604
10	MP0003136_yellow_coat_color	2.52605562
11	MP0005174_abnormal_tail_pigmentation	2.38935848
12	MP0003172_abnormal_lysosome_physiology	2.26977237
13	MP0005000_abnormal_immune_tolerance	2.26111113
14	MP0003436_decreased_susceptibility_to	2.25359375
15	MP0001986_abnormal_taste_sensitivity	2.22573579
16	MP0001835_abnormal_antigen_presentation	2.15002625
17	MP0005423_abnormal_somatic_nervous	2.10996089
18	MP0002166_altered_tumor_susceptibility	2.05778474
19	MP0002723_abnormal_immune_serum	2.04866801
20	MP0002933_joint_inflammation	1.98197156
21	MP0009333_abnormal_splenocyte_physiolog	1.96074192
22	MP0002398_abnormal_bone_marrow	1.94623725
23	MP0005409_darkened_coat_color	1.86373889
24	MP0005076_abnormal_cell_differentiation	1.84789186
25	MP0000013_abnormal_adipose_tissue	1.83871482
26	MP0000003_abnormal_adipose_tissue	1.83759110
27	MP0005171_absent_coat_pigmentation	1.81726006
28	MP0002452_abnormal_antigen_presenting	1.78383984
29	MP0002420_abnormal_adaptive_immunity	1.78055178
30	MP0001819_abnormal_immune_cell	1.75638076
31	MP0003111_abnormal_nucleus_morphology	1.68633553
32	MP0000716_abnormal_immune_system	1.68460437
33	MP0000703_abnormal_thymus_morphology	1.68101138
34	MP0001873_stomach_inflammation	1.65395982
35	MP0005025_abnormal_response_to	1.62373390
36	MP0001348_abnormal_lacrimal_gland	1.61717409
37	MP0005451_abnormal_body_composition	1.59583143
38	MP0004947_skin_inflammation	1.59031046
39	MP0002429_abnormal_blood_cell	1.53686874
40	MP0002722_abnormal_immune_system	1.50055065
41	MP0008875_abnormal_xenobiotic_pharmacok	1.48424667
42	MP0002089_abnormal_postnatal_growth/wei	1.48117230
43	MP0000015_abnormal_ear_pigmentation	1.45811441
44	MP0000371_diluted_coat_color	1.43870693
45	MP0000689_abnormal_spleen_morphology	1.42636867
46	MP0009840_abnormal_foam_cell	1.42353544
47	MP0002139_abnormal_hepatobiliary_system	1.33880989
48	MP0003183_abnormal_peptide_metabolism	1.32553401
49	MP0001188_hyperpigmentation	1.32377188
50	MP0005167_abnormal_blood-brain_barrier	1.28090008
51	MP0010329_abnormal_lipoprotein_level	1.27716864
52	MP0003879_abnormal_hair_cell	1.27411013
53	MP0003303_peritoneal_inflammation	1.27344368
54	MP0002160_abnormal_reproductive_system	1.26087940
55	MP0002006_tumorigenesis	1.22865609
56	MP0005058_abnormal_lysosome_morphology	1.21822572
57	MP0001661_extended_life_span	1.21020142
58	MP0005365_abnormal_bile_salt	1.18422454
59	MP0010155_abnormal_intestine_physiology	1.16983773
60	MP0001270_distended_abdomen	1.16590347
61	MP0002138_abnormal_hepatobiliary_system	1.13227704
62	MP0000609_abnormal_liver_physiology	1.10090311
63	MP0002405_respiratory_system_inflammati	1.09551445
64	MP0001502_abnormal_circadian_rhythm	1.08497091
65	MP0009785_altered_susceptibility_to	1.05039858
66	MP0002019_abnormal_tumor_incidence	0.99330323
67	MP0010094_abnormal_chromosome_stability	0.99290827
68	MP0001845_abnormal_inflammatory_respons	0.98454831
69	MP0002419_abnormal_innate_immunity	0.97477169
70	MP0005220_abnormal_exocrine_pancreas	0.89267728
71	MP0005083_abnormal_biliary_tract	0.84632329
72	MP0005332_abnormal_amino_acid	0.84397683
73	MP0002136_abnormal_kidney_physiology	0.83859425
74	MP0002075_abnormal_coat/hair_pigmentati	0.80767054
75	MP0003045_fibrosis	0.78931743
76	MP0005464_abnormal_platelet_physiology	0.78811243
77	MP0002998_abnormal_bone_remodeling	0.76705608
78	MP0008469_abnormal_protein_level	0.75811237
79	MP0005394_taste/olfaction_phenotype	0.75649731
80	MP0005499_abnormal_olfactory_system	0.75649731
81	MP0002118_abnormal_lipid_homeostasis	0.74945774
82	MP0005084_abnormal_gallbladder_morpholo	0.74255177
83	MP0003866_abnormal_defecation	0.73844826
84	MP0009046_muscle_twitch	0.72770181
85	MP0005623_abnormal_meninges_morphology	0.72288531
86	MP0005310_abnormal_salivary_gland	0.71539835
87	MP0001756_abnormal_urination	0.71420517
88	MP0005375_adipose_tissue_phenotype	0.71381995
89	MP0009643_abnormal_urine_homeostasis	0.70575613
90	MP0003077_abnormal_cell_cycle	0.68898245
91	MP0001765_abnormal_ion_homeostasis	0.68238442
92	MP0001919_abnormal_reproductive_system	0.67252575
93	MP0003656_abnormal_erythrocyte_physiolo	0.67143569
94	MP0005330_cardiomyopathy	0.66909845
95	MP0002148_abnormal_hypersensitivity_rea	0.66557853
96	MP0005389_reproductive_system_phenotype	0.65098808
97	MP0001666_abnormal_nutrient_absorption	0.63676305
98	MP0003453_abnormal_keratinocyte_physiol	0.62264612
99	MP0000858_altered_metastatic_potential	0.61431207
100	MP0000747_muscle_weakness	0.60540633

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Gastrointestinal stroma tumor (HP:0100723)	5.42755805
2	Hemorrhage of the eye (HP:0011885)	4.64444830
3	Joint hemorrhage (HP:0005261)	4.60765721
4	Recurrent sinusitis (HP:0011108)	4.22813586
5	IgA deficiency (HP:0002720)	4.14041195
6	Deep venous thrombosis (HP:0002625)	4.09178098
7	Squamous cell carcinoma (HP:0002860)	4.00584287
8	Prolonged partial thromboplastin time (HP:0003645)	3.91113249
9	Emphysema (HP:0002097)	3.73494997
10	Poikiloderma (HP:0001029)	3.64320955
11	Vaginal fistula (HP:0004320)	3.50222756
12	Conical tooth (HP:0000698)	3.47642314
13	IgG deficiency (HP:0004315)	3.37854110
14	Basal cell carcinoma (HP:0002671)	3.26995128
15	Small epiphyses (HP:0010585)	3.19170841
16	Recurrent bronchitis (HP:0002837)	3.18888854
17	Facial hemangioma (HP:0000329)	3.17642668
18	Vasculitis (HP:0002633)	3.16872239
19	Lymphopenia (HP:0001888)	3.09728207
20	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	3.09696474
21	Agammaglobulinemia (HP:0004432)	3.03377225
22	IgM deficiency (HP:0002850)	3.02704104
23	Intestinal fistula (HP:0100819)	2.99623986
24	Colitis (HP:0002583)	2.95011475
25	Abnormality of cells of the lymphoid lineage (HP:0012140)	2.93759355
26	Meningitis (HP:0001287)	2.92353490
27	Abnormality of the intrinsic pathway (HP:0010989)	2.87019403
28	Rectovaginal fistula (HP:0000143)	2.81531843
29	Rectal fistula (HP:0100590)	2.81531843
30	Capillary hemangiomas (HP:0005306)	2.79507033
31	Annular pancreas (HP:0001734)	2.56454463
32	Ulnar bowing (HP:0003031)	2.56311165
33	Testicular atrophy (HP:0000029)	2.53146874
34	Restrictive lung disease (HP:0002091)	2.51807453
35	Thin bony cortex (HP:0002753)	2.48371428
36	Abnormality of T cell physiology (HP:0011840)	2.40122392
37	Optic neuritis (HP:0100653)	2.36668845
38	Retrobulbar optic neuritis (HP:0100654)	2.36668845
39	Pustule (HP:0200039)	2.36264590
40	Abnormality of the common coagulation pathway (HP:0010990)	2.34301142
41	Flattened epiphyses (HP:0003071)	2.29574210
42	Panhypogammaglobulinemia (HP:0003139)	2.27364807
43	Recurrent fungal infections (HP:0002841)	2.19998135
44	Chronic diarrhea (HP:0002028)	2.18291606
45	Gastrointestinal infarctions (HP:0005244)	2.14187428
46	Mediastinal lymphadenopathy (HP:0100721)	2.13852040
47	Anteriorly placed anus (HP:0001545)	2.12911472
48	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.12860024
49	Abnormality of T cells (HP:0002843)	2.11486574
50	Hypobetalipoproteinemia (HP:0003563)	2.08045663
51	Gastrointestinal inflammation (HP:0004386)	2.07296090
52	Xanthomatosis (HP:0000991)	2.06956728
53	Short chin (HP:0000331)	2.06326001
54	Inflammation of the large intestine (HP:0002037)	2.04539955
55	Patellar aplasia (HP:0006443)	2.04009711
56	Hypophosphatemic rickets (HP:0004912)	2.03761257
57	Recurrent cutaneous fungal infections (HP:0011370)	2.02409137
58	Chronic mucocutaneous candidiasis (HP:0002728)	2.02409137
59	Recurrent otitis media (HP:0000403)	2.02274122
60	Severe combined immunodeficiency (HP:0004430)	2.01549199
61	Facial diplegia (HP:0001349)	2.00232955
62	Hyperacusis (HP:0010780)	1.98834847
63	Hypochromic anemia (HP:0001931)	1.98636332
64	Recurrent viral infections (HP:0004429)	1.98122305
65	Akinesia (HP:0002304)	1.97607708
66	Rib fusion (HP:0000902)	1.94771953
67	Pulmonary infiltrates (HP:0002113)	1.93950405
68	Abnormality of the pleura (HP:0002103)	1.91999132
69	B lymphocytopenia (HP:0010976)	1.88794967
70	Abnormality of the fingertips (HP:0001211)	1.88083098
71	Lymphoma (HP:0002665)	1.87953090
72	Orchitis (HP:0100796)	1.86615758
73	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.85817147
74	Attenuation of retinal blood vessels (HP:0007843)	1.82121292
75	Leukopenia (HP:0001882)	1.81432992
76	Pigmentary retinal degeneration (HP:0001146)	1.80283260
77	Self-mutilation (HP:0000742)	1.79915317
78	Cellulitis (HP:0100658)	1.78404053
79	Abnormality of eosinophils (HP:0001879)	1.77621407
80	Aplasia/Hypoplasia of the patella (HP:0006498)	1.76140137
81	Mesangial abnormality (HP:0001966)	1.73294204
82	Recurrent pneumonia (HP:0006532)	1.72106007
83	Purpura (HP:0000979)	1.69260546
84	Easy fatigability (HP:0003388)	1.69148685
85	Nonimmune hydrops fetalis (HP:0001790)	1.68916580
86	Hypertensive crisis (HP:0100735)	1.67341276
87	Dry hair (HP:0011359)	1.66108424
88	Recurrent lower respiratory tract infections (HP:0002783)	1.65276100
89	Hypotrichosis (HP:0001006)	1.64530654
90	Epiphyseal dysplasia (HP:0002656)	1.64146738
91	Irregular epiphyses (HP:0010582)	1.63560758
92	Pulmonary embolism (HP:0002204)	1.63242886
93	Arterial thrombosis (HP:0004420)	1.62562225
94	Hypercholesterolemia (HP:0003124)	1.62155705
95	Myopathic facies (HP:0002058)	1.62013545
96	Absent epiphyses (HP:0010577)	1.61063823
97	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.61063823
98	Abnormality of male internal genitalia (HP:0000022)	1.60739518
99	Asymmetry of the thorax (HP:0001555)	1.59961512
100	Arthralgia (HP:0002829)	1.59923986

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	4.09633775
2	TRIB3	3.78855086
3	FGFR4	3.67917058
4	SIK2	3.65031594
5	MAP4K1	3.16775813
6	MAP3K14	2.51878591
7	CDK12	2.45209071
8	SMG1	2.43232289
9	ERN1	2.40951102
10	EEF2K	2.33353596
11	ICK	2.32910279
12	WNK4	2.29631010
13	SIK1	2.19577688
14	TXK	2.08393267
15	MAPK15	2.06230344
16	TBK1	2.05343355
17	RIPK4	2.04947366
18	ZAK	1.96869426
19	MAP3K13	1.92675772
20	IKBKE	1.82023526
21	FGFR3	1.78491159
22	MAPK11	1.59022634
23	MARK3	1.54853795
24	MAP3K10	1.44438285
25	PRPF4B	1.42271343
26	GRK6	1.37089806
27	IKBKB	1.30753573
28	SYK	1.25016662
29	KDR	1.21567413
30	TESK2	1.21162435
31	TAOK3	1.18162229
32	PDPK1	1.13743094
33	BLK	1.12325933
34	PKN2	1.12097143
35	IRAK4	1.11066401
36	NEK2	1.07420903
37	TYRO3	1.06139330
38	MAPKAPK3	1.04276280
39	VRK1	1.02444292
40	MAP2K2	1.02429245
41	JAK1	1.01557566
42	CDC42BPA	0.97918451
43	CHUK	0.97130060
44	PDK1	0.94575088
45	CSF1R	0.93992762
46	RPS6KA5	0.93305781
47	BTK	0.92567212
48	MAP3K9	0.92102159
49	CDK4	0.86946986
50	PRKCQ	0.86057411
51	ARAF	0.85570143
52	MAPK12	0.84944387
53	DAPK3	0.82737332
54	WNK1	0.81353133
55	NEK9	0.78954566
56	KIT	0.78503432
57	SIK3	0.77110413
58	DYRK1B	0.76272796
59	MATK	0.76078434
60	LYN	0.69231448
61	CSK	0.68871894
62	RET	0.67454412
63	PRKD2	0.66508511
64	MAP2K6	0.63665489
65	LCK	0.61980879
66	MARK2	0.60735616
67	MUSK	0.60636829
68	MTOR	0.59773690
69	BRD4	0.57022416
70	CDK7	0.56031604
71	JAK3	0.55117646
72	MELK	0.50235898
73	PIM2	0.47715889
74	RPS6KB2	0.47604759
75	FGFR2	0.47421025
76	AURKA	0.46635095
77	KSR2	0.45124725
78	FES	0.44507037
79	ZAP70	0.44047583
80	PRKAA1	0.42718117
81	RPS6KA2	0.42325072
82	PKN1	0.42218432
83	PIM1	0.42045923
84	TNK2	0.42015083
85	PTK6	0.41819834
86	MAPK7	0.41512186
87	HIPK2	0.41011560
88	ITK	0.40600223
89	PDGFRA	0.38225933
90	MAP3K7	0.36067348
91	SGK223	0.35546514
92	SGK494	0.35546514
93	MAPKAPK2	0.33108692
94	HCK	0.33097518
95	AKT2	0.31389854
96	MAPK3	0.30576084
97	MAPK8	0.29694055
98	MAP3K1	0.27645213
99	CAMKK1	0.27224742
100	CSNK1D	0.26527566

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	4.58597136
2	Primary immunodeficiency_Homo sapiens_hsa05340	4.01189975
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.82513385
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.30372388
5	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.08299976
6	Allograft rejection_Homo sapiens_hsa05330	2.84505283
7	Alcoholism_Homo sapiens_hsa05034	2.73061552
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.66941575
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.33739450
10	Sulfur relay system_Homo sapiens_hsa04122	2.32269800
11	Asthma_Homo sapiens_hsa05310	2.19478370
12	Other glycan degradation_Homo sapiens_hsa00511	2.09665367
13	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.99707765
14	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.95741594
15	Type I diabetes mellitus_Homo sapiens_hsa04940	1.90482270
16	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.89422675
17	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.86365078
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.72634696
19	Viral carcinogenesis_Homo sapiens_hsa05203	1.54730782
20	Viral myocarditis_Homo sapiens_hsa05416	1.46487002
21	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.41319669
22	Herpes simplex infection_Homo sapiens_hsa05168	1.35152183
23	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.30372246
24	Leishmaniasis_Homo sapiens_hsa05140	1.26398910
25	Phenylalanine metabolism_Homo sapiens_hsa00360	1.23061628
26	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.20114622
27	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.16946036
28	Influenza A_Homo sapiens_hsa05164	1.12250973
29	Antigen processing and presentation_Homo sapiens_hsa04612	1.04704214
30	Measles_Homo sapiens_hsa05162	1.02677169
31	Apoptosis_Homo sapiens_hsa04210	1.01455310
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.00191540
33	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.99380796
34	Non-small cell lung cancer_Homo sapiens_hsa05223	0.94070074
35	Toxoplasmosis_Homo sapiens_hsa05145	0.93050072
36	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.90725927
37	Hepatitis B_Homo sapiens_hsa05161	0.90474892
38	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.89147049
39	ABC transporters_Homo sapiens_hsa02010	0.88358525
40	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.83605039
41	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.82850754
42	Sphingolipid metabolism_Homo sapiens_hsa00600	0.82497644
43	Lysine degradation_Homo sapiens_hsa00310	0.79500950
44	Hepatitis C_Homo sapiens_hsa05160	0.77680640
45	Arginine biosynthesis_Homo sapiens_hsa00220	0.77024254
46	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.76835808
47	Acute myeloid leukemia_Homo sapiens_hsa05221	0.75398041
48	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.74419974
49	Complement and coagulation cascades_Homo sapiens_hsa04610	0.72437146
50	Insulin resistance_Homo sapiens_hsa04931	0.70514052
51	HTLV-I infection_Homo sapiens_hsa05166	0.70403979
52	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.69964353
53	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.68321151
54	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.67306653
55	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.67064235
56	VEGF signaling pathway_Homo sapiens_hsa04370	0.65768754
57	TNF signaling pathway_Homo sapiens_hsa04668	0.65054758
58	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.64077295
59	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.59797910
60	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.59571793
61	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.59158069
62	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.54632509
63	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.53943748
64	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.53204814
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.52541357
66	Circadian rhythm_Homo sapiens_hsa04710	0.51986042
67	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.51563195
68	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.49420217
69	One carbon pool by folate_Homo sapiens_hsa00670	0.49395768
70	Tuberculosis_Homo sapiens_hsa05152	0.49052210
71	mTOR signaling pathway_Homo sapiens_hsa04150	0.48886608
72	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.48686467
73	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.48444088
74	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.48229442
75	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.44951257
76	Osteoclast differentiation_Homo sapiens_hsa04380	0.44532883
77	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.43890424
78	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.40379719
79	Small cell lung cancer_Homo sapiens_hsa05222	0.40107582
80	MAPK signaling pathway_Homo sapiens_hsa04010	0.39295124
81	Prostate cancer_Homo sapiens_hsa05215	0.38204911
82	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.37707260
83	Endometrial cancer_Homo sapiens_hsa05213	0.36057193
84	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.35922808
85	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.34572280
86	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.31838907
87	Bladder cancer_Homo sapiens_hsa05219	0.31492212
88	PPAR signaling pathway_Homo sapiens_hsa03320	0.31310975
89	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.29630320
90	Base excision repair_Homo sapiens_hsa03410	0.27040044
91	Prolactin signaling pathway_Homo sapiens_hsa04917	0.27028958
92	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.22432082
93	p53 signaling pathway_Homo sapiens_hsa04115	0.21172252
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.21043647
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.20762814
96	Arginine and proline metabolism_Homo sapiens_hsa00330	0.20389042
97	Insulin signaling pathway_Homo sapiens_hsa04910	0.19829597
98	Chemokine signaling pathway_Homo sapiens_hsa04062	0.19233843
99	FoxO signaling pathway_Homo sapiens_hsa04068	0.18793715
100	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.18063433

LINC00176

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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