ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fusion of sperm to egg plasma membrane (GO:0007342)	9.98325712
2	spermatid development (GO:0007286)	9.18155663
3	sperm capacitation (GO:0048240)	8.20628286
4	multicellular organism reproduction (GO:0032504)	8.10508621
5	response to pheromone (GO:0019236)	7.99643122
6	sperm-egg recognition (GO:0035036)	7.76666889
7	plasma membrane fusion (GO:0045026)	7.70357059
8	spermatid nucleus differentiation (GO:0007289)	7.27573053
9	binding of sperm to zona pellucida (GO:0007339)	7.16359669
10	reproduction (GO:0000003)	7.01470540
11	chromosome condensation (GO:0030261)	7.00649359
12	axonemal dynein complex assembly (GO:0070286)	6.91880376
13	single strand break repair (GO:0000012)	6.88360630
14	DNA packaging (GO:0006323)	6.82672182
15	cell-cell recognition (GO:0009988)	6.50774061
16	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.49115851
17	microtubule depolymerization (GO:0007019)	6.41891462
18	rRNA methylation (GO:0031167)	6.23920291
19	calcium ion-dependent exocytosis (GO:0017156)	6.22087415
20	protein polyglutamylation (GO:0018095)	6.13056214
21	motile cilium assembly (GO:0044458)	6.10356761
22	phosphatidylethanolamine metabolic process (GO:0046337)	6.03305644
23	cilium or flagellum-dependent cell motility (GO:0001539)	5.83625661
24	regulation of cilium movement (GO:0003352)	5.78063426
25	negative regulation of inclusion body assembly (GO:0090084)	5.70601103
26	spermatogenesis (GO:0007283)	5.47926953
27	male gamete generation (GO:0048232)	5.46020831
28	rRNA modification (GO:0000154)	5.45113940
29	protein targeting to Golgi (GO:0000042)	5.35832334
30	cellular ketone body metabolic process (GO:0046950)	5.32341483
31	organic cation transport (GO:0015695)	5.31962191
32	single fertilization (GO:0007338)	5.27065202
33	establishment of protein localization to Golgi (GO:0072600)	5.14404869
34	regulation of phosphoprotein phosphatase activity (GO:0043666)	5.13986642
35	sexual reproduction (GO:0019953)	5.09494162
36	germ cell development (GO:0007281)	5.07178553
37	epithelial cilium movement (GO:0003351)	5.06104797
38	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.00249872
39	gamete generation (GO:0007276)	4.99096068
40	microtubule polymerization or depolymerization (GO:0031109)	4.97331003
41	regulation of Rab GTPase activity (GO:0032313)	4.69492600
42	positive regulation of Rab GTPase activity (GO:0032851)	4.69492600
43	regulation of transcription involved in cell fate commitment (GO:0060850)	4.68073308
44	ketone body metabolic process (GO:1902224)	4.66958739
45	microtubule severing (GO:0051013)	4.65965342
46	male meiosis (GO:0007140)	4.61521772
47	protein-DNA complex disassembly (GO:0032986)	4.60985343
48	nucleosome disassembly (GO:0006337)	4.60985343
49	centriole replication (GO:0007099)	4.60777280
50	centriole assembly (GO:0098534)	4.59679593
51	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.52525730
52	coenzyme catabolic process (GO:0009109)	4.50765763
53	cilium movement (GO:0003341)	4.40655120
54	fertilization (GO:0009566)	4.31985397
55	RNA destabilization (GO:0050779)	4.28993397
56	polyamine biosynthetic process (GO:0006596)	4.25784658
57	protein localization to Golgi apparatus (GO:0034067)	4.06076190
58	regulation of microtubule-based movement (GO:0060632)	4.02644505
59	multicellular organismal reproductive process (GO:0048609)	3.99971743
60	seminiferous tubule development (GO:0072520)	3.96180888
61	regulation of inclusion body assembly (GO:0090083)	3.89782032
62	cell wall macromolecule metabolic process (GO:0044036)	3.88445762
63	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.79371633
64	cell wall macromolecule catabolic process (GO:0016998)	3.76578746
65	response to acidic pH (GO:0010447)	3.74096166
66	regulation of somitogenesis (GO:0014807)	3.71800408
67	chromatin silencing (GO:0006342)	3.66430820
68	NAD biosynthetic process (GO:0009435)	3.49820072
69	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.42883740
70	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.38482206
71	nucleus organization (GO:0006997)	3.33791925
72	negative regulation of Rho protein signal transduction (GO:0035024)	3.31748420
73	positive regulation of catecholamine secretion (GO:0033605)	3.21657167
74	cellular response to pH (GO:0071467)	3.17744503
75	piRNA metabolic process (GO:0034587)	3.14967900
76	positive regulation of guanylate cyclase activity (GO:0031284)	3.11089670
77	peptidyl-threonine dephosphorylation (GO:0035970)	3.08610580
78	histone exchange (GO:0043486)	3.05126057
79	cell recognition (GO:0008037)	3.03810890
80	cranial nerve morphogenesis (GO:0021602)	3.00614832
81	amine biosynthetic process (GO:0009309)	2.99526931
82	cellular biogenic amine biosynthetic process (GO:0042401)	2.99001515
83	male meiosis I (GO:0007141)	2.98278206
84	DNA methylation involved in gamete generation (GO:0043046)	2.97183939
85	multicellular organismal development (GO:0007275)	2.96096878
86	cerebral cortex neuron differentiation (GO:0021895)	2.93232528
87	ventricular system development (GO:0021591)	2.92482228
88	regulation of guanylate cyclase activity (GO:0031282)	2.91878798
89	multicellular organismal movement (GO:0050879)	2.86722758
90	musculoskeletal movement (GO:0050881)	2.86722758
91	regulation of centriole replication (GO:0046599)	2.86080677
92	mast cell activation involved in immune response (GO:0002279)	2.83463766
93	mast cell degranulation (GO:0043303)	2.83463766
94	histone H3-K9 demethylation (GO:0033169)	2.80731119
95	male sex determination (GO:0030238)	2.78626175
96	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	2.77512517
97	axoneme assembly (GO:0035082)	2.76383153
98	homeostasis of number of cells within a tissue (GO:0048873)	2.75708062
99	acrosome reaction (GO:0007340)	11.8997070
100	sperm motility (GO:0030317)	11.8878019

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.20281556
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.06981682
3	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.95551473
4	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.75083673
5	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.46303160
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.41767947
7	CBP_20019798_ChIP-Seq_JUKART_Human	2.28146010
8	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.28146010
9	NANOG_20526341_ChIP-Seq_ESCs_Human	2.22953968
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.21056379
11	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.18481954
12	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.18481954
13	ERA_21632823_ChIP-Seq_H3396_Human	2.16959906
14	RAC3_21632823_ChIP-Seq_H3396_Human	2.12578468
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.11550414
16	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.08674297
17	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	2.07524757
18	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	2.06145263
19	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.02581705
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.99631366
21	FUS_26573619_Chip-Seq_HEK293_Human	1.99567461
22	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.91081129
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.90613606
24	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.85993844
25	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.78876642
26	BCL6_27268052_Chip-Seq_Bcells_Human	1.78532019
27	OCT4_20526341_ChIP-Seq_ESCs_Human	1.77513881
28	MYC_19829295_ChIP-Seq_ESCs_Human	1.76072759
29	E2F1_20622854_ChIP-Seq_HELA_Human	1.72359335
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69742712
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68925248
32	CTCF_27219007_Chip-Seq_Bcells_Human	1.68717794
33	PHF8_20622854_ChIP-Seq_HELA_Human	1.66272083
34	CTCF_20526341_ChIP-Seq_ESCs_Human	1.64447666
35	P300_27268052_Chip-Seq_Bcells_Human	1.64444304
36	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.63163461
37	P68_20966046_ChIP-Seq_HELA_Human	1.60726597
38	BCOR_27268052_Chip-Seq_Bcells_Human	1.59084738
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.56980285
40	TAF2_19829295_ChIP-Seq_ESCs_Human	1.55516868
41	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.55119397
42	SMC4_20622854_ChIP-Seq_HELA_Human	1.55027822
43	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.53909349
44	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.49670280
45	ERG_20517297_ChIP-Seq_VCAP_Human	1.48798247
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.48289045
47	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.47753111
48	IGF1R_20145208_ChIP-Seq_DFB_Human	1.44382894
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.44299290
50	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.43197018
51	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.42921863
52	DROSHA_22980978_ChIP-Seq_HELA_Human	1.40780248
53	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.39232126
54	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.37573086
55	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.37169588
56	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.36952914
57	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.34638263
58	AR_25329375_ChIP-Seq_VCAP_Human	1.33556770
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.31226252
60	AR_21572438_ChIP-Seq_LNCaP_Human	1.30457030
61	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.29426020
62	SPI1_20517297_ChIP-Seq_HL60_Human	1.28891700
63	P300_19829295_ChIP-Seq_ESCs_Human	1.27741353
64	TP63_22573176_ChIP-Seq_HFKS_Human	1.26376996
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.24654942
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.24654942
67	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.24504855
68	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.23995572
69	HOXB7_26014856_ChIP-Seq_BT474_Human	1.23955368
70	RBPJ_21746931_ChIP-Seq_IB4_Human	1.20861431
71	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.20310887
72	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19925580
73	TBL1_22424771_ChIP-Seq_293T_Human	1.18958076
74	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17634804
75	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.14703729
76	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.14533014
77	CEBPB_22108803_ChIP-Seq_LS180_Human	1.14096740
78	PHF8_20622853_ChIP-Seq_HELA_Human	1.13022485
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.12932179
80	ETV1_20927104_ChIP-Seq_GIST48_Human	1.11981009
81	P53_21459846_ChIP-Seq_SAOS-2_Human	1.11473272
82	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.10902359
83	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.10158159
84	NCOR_22424771_ChIP-Seq_293T_Human	1.09174852
85	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.08330018
86	NFYB_21822215_ChIP-Seq_K562_Human	1.08043879
87	RUNX_20019798_ChIP-Seq_JUKART_Human	1.07933537
88	SMRT_27268052_Chip-Seq_Bcells_Human	1.03959373
89	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.03628750
90	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02959037
91	LXR_22292898_ChIP-Seq_THP-1_Human	1.02580941
92	TP53_18474530_ChIP-ChIP_U2OS_Human	1.01807642
93	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.01358554
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00657266
95	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.00490465
96	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.00355496
97	STAT1_20625510_ChIP-Seq_HELA_Human	1.00313935
98	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99840523
99	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99755580
100	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.99533479

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003698_abnormal_male_reproductive	4.45679733
2	MP0001929_abnormal_gametogenesis	3.88919445
3	MP0005377_hearing/vestibular/ear_phenot	3.76058615
4	MP0003878_abnormal_ear_physiology	3.76058615
5	MP0005670_abnormal_white_adipose	3.60633508
6	MP0002138_abnormal_hepatobiliary_system	2.60877999
7	MP0002132_abnormal_respiratory_system	2.42758477
8	MP0002161_abnormal_fertility/fecundity	2.41433237
9	MP0003646_muscle_fatigue	2.19553214
10	MP0000678_abnormal_parathyroid_gland	2.11848823
11	MP0001348_abnormal_lacrimal_gland	2.10780084
12	MP0005410_abnormal_fertilization	12.0085068
13	MP0003718_maternal_effect	1.94902282
14	MP0001968_abnormal_touch/_nociception	1.89203387
15	MP0002210_abnormal_sex_determination	1.87698307
16	MP0009697_abnormal_copulation	1.73630045
17	MP0001145_abnormal_male_reproductive	1.63228269
18	MP0008004_abnormal_stomach_pH	1.58492516
19	MP0000653_abnormal_sex_gland	1.55278364
20	MP0001905_abnormal_dopamine_level	1.41019185
21	MP0001485_abnormal_pinna_reflex	1.38715323
22	MP0008877_abnormal_DNA_methylation	1.28316034
23	MP0002249_abnormal_larynx_morphology	1.27547730
24	MP0002653_abnormal_ependyma_morphology	1.26125371
25	MP0002160_abnormal_reproductive_system	1.25307592
26	MP0005551_abnormal_eye_electrophysiolog	1.24378160
27	MP0002127_abnormal_cardiovascular_syste	1.23620543
28	MP0001486_abnormal_startle_reflex	1.19641403
29	MP0003011_delayed_dark_adaptation	1.14089854
30	MP0005379_endocrine/exocrine_gland_phen	1.13214745
31	MP0001765_abnormal_ion_homeostasis	1.11913238
32	MP0008995_early_reproductive_senescence	1.11667036
33	MP0001501_abnormal_sleep_pattern	1.06996058
34	MP0002735_abnormal_chemical_nociception	1.06740102
35	MP0003315_abnormal_perineum_morphology	1.02452081
36	MP0010386_abnormal_urinary_bladder	1.02059938
37	MP0002282_abnormal_trachea_morphology	1.00776564
38	MP0002822_catalepsy	0.99437215
39	MP0002234_abnormal_pharynx_morphology	0.98967749
40	MP0001984_abnormal_olfaction	0.98066819
41	MP0005423_abnormal_somatic_nervous	0.97081362
42	MP0005084_abnormal_gallbladder_morpholo	0.96847255
43	MP0005253_abnormal_eye_physiology	0.96194768
44	MP0001963_abnormal_hearing_physiology	0.90382330
45	MP0004085_abnormal_heartbeat	0.90169738
46	MP0005395_other_phenotype	0.86968723
47	MP0002229_neurodegeneration	0.86781161
48	MP0005167_abnormal_blood-brain_barrier	0.86124556
49	MP0004859_abnormal_synaptic_plasticity	0.85448046
50	MP0000230_abnormal_systemic_arterial	0.85408096
51	MP0005646_abnormal_pituitary_gland	0.80765125
52	MP0006036_abnormal_mitochondrial_physio	0.79660626
53	MP0004484_altered_response_of	0.79394389
54	MP0000026_abnormal_inner_ear	0.78927456
55	MP0002272_abnormal_nervous_system	0.78692668
56	MP0005647_abnormal_sex_gland	0.77497880
57	MP0002733_abnormal_thermal_nociception	0.75525081
58	MP0003879_abnormal_hair_cell	0.74041180
59	MP0000681_abnormal_thyroid_gland	0.73745490
60	MP0002067_abnormal_sensory_capabilities	0.72040748
61	MP0002557_abnormal_social/conspecific_i	0.72035783
62	MP0009745_abnormal_behavioral_response	0.69893365
63	MP0010368_abnormal_lymphatic_system	0.66022240
64	MP0004742_abnormal_vestibular_system	0.65876947
65	MP0005394_taste/olfaction_phenotype	0.65684432
66	MP0005499_abnormal_olfactory_system	0.65684432
67	MP0005636_abnormal_mineral_homeostasis	0.65215910
68	MP0002572_abnormal_emotion/affect_behav	0.64556860
69	MP0003136_yellow_coat_color	0.64410833
70	MP0001970_abnormal_pain_threshold	0.63634383
71	MP0005310_abnormal_salivary_gland	0.63621054
72	MP0004036_abnormal_muscle_relaxation	0.62606712
73	MP0002102_abnormal_ear_morphology	0.62152221
74	MP0009115_abnormal_fat_cell	0.60144067
75	MP0008872_abnormal_physiological_respon	0.59794662
76	MP0006072_abnormal_retinal_apoptosis	0.59199363
77	MP0006276_abnormal_autonomic_nervous	0.58400704
78	MP0000955_abnormal_spinal_cord	0.57639958
79	MP0000613_abnormal_salivary_gland	0.57151682
80	MP0008569_lethality_at_weaning	0.56771078
81	MP0005645_abnormal_hypothalamus_physiol	0.56640049
82	MP0000534_abnormal_ureter_morphology	0.56148269
83	MP0000470_abnormal_stomach_morphology	0.55353738
84	MP0001664_abnormal_digestion	0.54459201
85	MP0005083_abnormal_biliary_tract	0.53930838
86	MP0006292_abnormal_olfactory_placode	0.53628976
87	MP0000516_abnormal_urinary_system	0.53206927
88	MP0005367_renal/urinary_system_phenotyp	0.53206927
89	MP0005360_urolithiasis	0.53080202
90	MP0003045_fibrosis	0.52664982
91	MP0002837_dystrophic_cardiac_calcinosis	0.52145632
92	MP0003631_nervous_system_phenotype	0.51146820
93	MP0003936_abnormal_reproductive_system	0.50785795
94	MP0003137_abnormal_impulse_conducting	0.49056231
95	MP0005389_reproductive_system_phenotype	0.48471457
96	MP0001879_abnormal_lymphatic_vessel	0.47255708
97	MP0005397_hematopoietic_system_phenotyp	0.47148044
98	MP0001545_abnormal_hematopoietic_system	0.47148044
99	MP0002734_abnormal_mechanical_nocicepti	0.46558988
100	MP0002736_abnormal_nociception_after	0.45943489

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	6.44532036
2	Absent/shortened dynein arms (HP:0200106)	6.25500787
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.25500787
4	Abnormal respiratory motile cilium physiology (HP:0012261)	5.12566617
5	Abnormal ciliary motility (HP:0012262)	5.05782296
6	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.98823835
7	Attenuation of retinal blood vessels (HP:0007843)	4.93544761
8	Abnormal respiratory epithelium morphology (HP:0012253)	4.74052742
9	Abnormal respiratory motile cilium morphology (HP:0005938)	4.74052742
10	Abnormal rod and cone electroretinograms (HP:0008323)	4.65947014
11	Infertility (HP:0000789)	4.53596631
12	Resting tremor (HP:0002322)	4.52124359
13	Bony spicule pigmentary retinopathy (HP:0007737)	4.27897271
14	Asymmetric septal hypertrophy (HP:0001670)	3.78938382
15	Tubulointerstitial nephritis (HP:0001970)	3.77485424
16	Chronic hepatic failure (HP:0100626)	3.66655430
17	Azoospermia (HP:0000027)	3.51084065
18	Postural instability (HP:0002172)	3.43514603
19	Nasal polyposis (HP:0100582)	3.39307680
20	Abnormality of macular pigmentation (HP:0008002)	3.36606468
21	Cerebellar dysplasia (HP:0007033)	3.31591929
22	Abnormal spermatogenesis (HP:0008669)	3.29667251
23	Bell-shaped thorax (HP:0001591)	3.26105275
24	Polydipsia (HP:0001959)	3.26092917
25	Abnormal drinking behavior (HP:0030082)	3.26092917
26	Nephronophthisis (HP:0000090)	3.20224401
27	Potter facies (HP:0002009)	3.19953730
28	Facial shape deformation (HP:0011334)	3.19953730
29	Hyperkalemia (HP:0002153)	3.13379969
30	Male infertility (HP:0003251)	3.10482542
31	Abnormal urine output (HP:0012590)	3.10058685
32	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.07607512
33	Rhinitis (HP:0012384)	3.03717547
34	Occipital encephalocele (HP:0002085)	2.94174445
35	Hypoplasia of the thymus (HP:0000778)	2.90988544
36	Type II lissencephaly (HP:0007260)	2.88553181
37	Polyuria (HP:0000103)	2.80284643
38	Generalized aminoaciduria (HP:0002909)	2.74178375
39	Abnormality of renal excretion (HP:0011036)	2.72408866
40	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.70150571
41	Pancreatic cysts (HP:0001737)	2.66649970
42	Abnormality of the nasal mucosa (HP:0000433)	2.66572421
43	Hypoplastic ischia (HP:0003175)	2.65653556
44	Enlarged epiphyses (HP:0010580)	2.65600802
45	Pancreatic fibrosis (HP:0100732)	2.65578357
46	Impulsivity (HP:0100710)	2.59848877
47	Male pseudohermaphroditism (HP:0000037)	2.56018688
48	Abnormality of the renal medulla (HP:0100957)	2.55984953
49	Bronchiectasis (HP:0002110)	2.52788281
50	Renal dysplasia (HP:0000110)	2.50978440
51	Reduced antithrombin III activity (HP:0001976)	2.46861482
52	Abnormal sex determination (HP:0012244)	2.42298164
53	Sex reversal (HP:0012245)	2.42298164
54	Abnormality of the ischium (HP:0003174)	2.34882084
55	Abnormality of the aortic arch (HP:0012303)	2.33733528
56	Amelogenesis imperfecta (HP:0000705)	2.27290403
57	True hermaphroditism (HP:0010459)	2.27263518
58	Cone-rod dystrophy (HP:0000548)	2.20720754
59	Chronic bronchitis (HP:0004469)	2.20319993
60	Tetany (HP:0001281)	2.18002218
61	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.16499911
62	Cystic liver disease (HP:0006706)	2.16438522
63	Progressive cerebellar ataxia (HP:0002073)	2.16199705
64	Abnormality of potassium homeostasis (HP:0011042)	2.16128295
65	Abnormality of the columella (HP:0009929)	2.16096715
66	Stage 5 chronic kidney disease (HP:0003774)	2.15333978
67	Congenital sensorineural hearing impairment (HP:0008527)	2.13368494
68	Retinal dysplasia (HP:0007973)	2.11264263
69	Anterior segment dysgenesis (HP:0007700)	2.09923639
70	Recurrent corneal erosions (HP:0000495)	2.09110533
71	Abnormality of dental color (HP:0011073)	2.05163933
72	Abnormal biliary tract physiology (HP:0012439)	2.04942782
73	Bile duct proliferation (HP:0001408)	2.04942782
74	Optic nerve hypoplasia (HP:0000609)	2.04579607
75	Unilateral renal agenesis (HP:0000122)	2.02153020
76	Portal hypertension (HP:0001409)	2.02116068
77	Renal Fanconi syndrome (HP:0001994)	2.00550737
78	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.00185856
79	Hypoplasia of the uterus (HP:0000013)	1.99798716
80	Photophobia (HP:0000613)	1.99380471
81	Abnormality of the costochondral junction (HP:0000919)	1.98998198
82	Sensory axonal neuropathy (HP:0003390)	1.97697456
83	Spastic paraparesis (HP:0002313)	1.95318465
84	Tubulointerstitial abnormality (HP:0001969)	1.94135548
85	Gonadal dysgenesis (HP:0000133)	1.93989956
86	Abnormality of the hepatic vasculature (HP:0006707)	1.88742052
87	Myoglobinuria (HP:0002913)	1.86341459
88	Congenital stationary night blindness (HP:0007642)	1.85808129
89	Sclerocornea (HP:0000647)	1.82601128
90	Type II diabetes mellitus (HP:0005978)	1.81839484
91	Glycosuria (HP:0003076)	1.78120580
92	Abnormality of urine glucose concentration (HP:0011016)	1.78120580
93	Bulbous nose (HP:0000414)	1.77458317
94	Rhabdomyolysis (HP:0003201)	1.76299481
95	Atonic seizures (HP:0010819)	1.76108943
96	Double outlet right ventricle (HP:0001719)	1.75003854
97	Congenital malformation of the right heart (HP:0011723)	1.75003854
98	Hyperthyroidism (HP:0000836)	1.74501744
99	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.73091230
100	Colitis (HP:0002583)	1.72762517

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	6.03871859
2	PLK4	5.80679559
3	TESK1	4.33890642
4	MAP4K2	4.06449501
5	DDR2	3.21491411
6	STK38	3.16706665
7	INSRR	3.02693195
8	MAPK15	2.95598614
9	TLK1	2.76579589
10	ZAK	2.51983828
11	MARK3	2.42474511
12	STK38L	2.25692493
13	PLK2	2.19398292
14	FRK	1.85564388
15	PNCK	1.85531002
16	BRD4	1.76575559
17	CAMK1G	1.48693147
18	PRKD3	1.45309745
19	PTK2B	1.43574347
20	RPS6KA5	1.42512650
21	PIK3CG	1.40093431
22	PDK1	1.39604688
23	NEK2	1.37897045
24	PDPK1	1.30204515
25	CDK3	1.17773428
26	MST1R	1.17479245
27	TIE1	1.09041640
28	BMPR1B	1.05646732
29	TAOK3	1.04880325
30	ADRBK2	1.01599854
31	LATS1	1.00451420
32	WNK4	0.94421716
33	CDK7	0.89348765
34	MYLK	0.86105429
35	MAP2K7	0.81509280
36	BCKDK	0.79718033
37	RIPK4	0.78973838
38	PRKCQ	0.77974643
39	OXSR1	0.75791780
40	NEK6	0.73183395
41	CAMK1	0.72259397
42	STK39	0.69979521
43	ARAF	0.69861110
44	SIK2	0.67492088
45	CDK12	0.66956859
46	OBSCN	0.66582958
47	CAMK1D	0.64588911
48	DYRK1B	0.62693642
49	PRKG1	0.61654315
50	MAP4K1	0.61646617
51	VRK1	0.60663034
52	SGK223	0.60500219
53	SGK494	0.60500219
54	PRKG2	0.60199229
55	KIT	0.60100609
56	WNK1	0.60092033
57	GRK1	0.56713178
58	RPS6KA1	0.54529596
59	MAP3K1	0.49067468
60	CSNK1G3	0.48504708
61	TESK2	0.48025809
62	ROCK1	0.46850417
63	FES	0.43400969
64	MUSK	0.43082100
65	GRK6	0.42237935
66	WNK3	0.40962321
67	CSNK1A1L	0.39203599
68	MAP3K11	0.38730750
69	MAPK13	0.37374177
70	SYK	0.35685184
71	CDK19	0.32876866
72	MAPK1	0.32764247
73	GSK3B	0.32478422
74	MAPK11	0.32444107
75	KDR	0.31870831
76	TNK2	0.29139556
77	MAP2K6	0.28448393
78	CDK2	0.28269958
79	RPS6KA2	0.27517750
80	DYRK3	0.27430641
81	CAMK4	0.27136897
82	PRKAA2	0.23966410
83	CDK14	0.23889217
84	PKN1	0.23371402
85	IKBKB	0.22996252
86	TEC	0.22947999
87	CSNK1G2	0.22507269
88	CSNK1G1	0.22467210
89	RPS6KA6	0.21811264
90	CDK1	0.21763984
91	MAPK8	0.21174159
92	KSR2	0.21150917
93	MAP3K13	0.21144897
94	CDK4	0.20989169
95	BRAF	0.19898415
96	MINK1	0.18862243
97	CSNK1A1	0.18195666
98	JAK3	0.18127037
99	TXK	0.17095891
100	PRKCB	0.16913897

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.86197164
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	4.80321870
3	Olfactory transduction_Homo sapiens_hsa04740	3.88363580
4	Butanoate metabolism_Homo sapiens_hsa00650	3.10046789
5	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	2.36036718
6	Phototransduction_Homo sapiens_hsa04744	2.35959103
7	Allograft rejection_Homo sapiens_hsa05330	2.19318764
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.19115458
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.18181556
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.09111535
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.06890107
12	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.77685237
13	Taste transduction_Homo sapiens_hsa04742	1.73026609
14	Antigen processing and presentation_Homo sapiens_hsa04612	1.64912026
15	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.58637529
16	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.57213044
17	Fatty acid degradation_Homo sapiens_hsa00071	1.54125296
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.51080342
19	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.39996420
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.34954144
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.33220150
22	Fatty acid metabolism_Homo sapiens_hsa01212	1.32027112
23	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.30289866
24	Salivary secretion_Homo sapiens_hsa04970	1.26545160
25	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.21542305
26	Arginine biosynthesis_Homo sapiens_hsa00220	1.15299167
27	RNA transport_Homo sapiens_hsa03013	1.10735109
28	Propanoate metabolism_Homo sapiens_hsa00640	1.10466674
29	Gap junction_Homo sapiens_hsa04540	1.09997323
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.08224955
31	Purine metabolism_Homo sapiens_hsa00230	1.05519216
32	Calcium signaling pathway_Homo sapiens_hsa04020	1.03542061
33	Phenylalanine metabolism_Homo sapiens_hsa00360	1.02779167
34	Alcoholism_Homo sapiens_hsa05034	1.02631093
35	PPAR signaling pathway_Homo sapiens_hsa03320	0.99901596
36	Type II diabetes mellitus_Homo sapiens_hsa04930	0.99759085
37	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.99221966
38	Renin secretion_Homo sapiens_hsa04924	0.98871554
39	Circadian entrainment_Homo sapiens_hsa04713	0.98103833
40	Asthma_Homo sapiens_hsa05310	0.97611070
41	Viral myocarditis_Homo sapiens_hsa05416	0.96224056
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.96130404
43	Basal transcription factors_Homo sapiens_hsa03022	0.95570942
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.94297273
45	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.91108758
46	ABC transporters_Homo sapiens_hsa02010	0.85137342
47	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.82515077
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.81372214
49	Linoleic acid metabolism_Homo sapiens_hsa00591	0.80073212
50	Phagosome_Homo sapiens_hsa04145	0.79550778
51	Peroxisome_Homo sapiens_hsa04146	0.77978050
52	Cardiac muscle contraction_Homo sapiens_hsa04260	0.76669581
53	Tryptophan metabolism_Homo sapiens_hsa00380	0.75973137
54	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.72655774
55	Tyrosine metabolism_Homo sapiens_hsa00350	0.69284713
56	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.67492872
57	Primary immunodeficiency_Homo sapiens_hsa05340	0.66401938
58	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.66150889
59	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.63043511
60	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.62568973
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61884408
62	Arginine and proline metabolism_Homo sapiens_hsa00330	0.60748877
63	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.59924124
64	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.59378918
65	Morphine addiction_Homo sapiens_hsa05032	0.58982235
66	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.58398402
67	Oocyte meiosis_Homo sapiens_hsa04114	0.58115640
68	Regulation of autophagy_Homo sapiens_hsa04140	0.56390355
69	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.55745935
70	Retinol metabolism_Homo sapiens_hsa00830	0.53478136
71	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.52951125
72	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.52261557
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.52092396
74	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.50992689
75	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.50309787
76	Glutathione metabolism_Homo sapiens_hsa00480	0.49564934
77	Gastric acid secretion_Homo sapiens_hsa04971	0.47750995
78	Pyruvate metabolism_Homo sapiens_hsa00620	0.47607590
79	Glycerolipid metabolism_Homo sapiens_hsa00561	0.46848671
80	Influenza A_Homo sapiens_hsa05164	0.43862717
81	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.43410092
82	Metabolic pathways_Homo sapiens_hsa01100	0.43368688
83	Huntingtons disease_Homo sapiens_hsa05016	0.41632704
84	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.39356781
85	cAMP signaling pathway_Homo sapiens_hsa04024	0.39194628
86	Herpes simplex infection_Homo sapiens_hsa05168	0.39170576
87	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.36828599
88	Fat digestion and absorption_Homo sapiens_hsa04975	0.36681431
89	Nicotine addiction_Homo sapiens_hsa05033	0.36601897
90	Protein digestion and absorption_Homo sapiens_hsa04974	0.35637231
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.34183891
92	Apoptosis_Homo sapiens_hsa04210	0.33801035
93	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.33469584
94	Base excision repair_Homo sapiens_hsa03410	0.32588049
95	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.31691436
96	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.31420056
97	Endocytosis_Homo sapiens_hsa04144	0.29218620
98	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.29210547
99	Insulin secretion_Homo sapiens_hsa04911	0.29174177
100	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.27581844

LINC00202-2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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