ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	7.82339925
2	acrosome reaction (GO:0007340)	7.54093885
3	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	7.24229668
4	spermatid development (GO:0007286)	6.56086706
5	regulation of phosphoprotein phosphatase activity (GO:0043666)	6.52867344
6	motile cilium assembly (GO:0044458)	6.51268015
7	multicellular organism reproduction (GO:0032504)	6.19348310
8	coenzyme catabolic process (GO:0009109)	5.38281776
9	positive regulation of catecholamine secretion (GO:0033605)	5.35421969
10	axonemal dynein complex assembly (GO:0070286)	5.32773006
11	fusion of sperm to egg plasma membrane (GO:0007342)	5.00850153
12	binding of sperm to zona pellucida (GO:0007339)	4.98555452
13	sperm-egg recognition (GO:0035036)	4.85172787
14	cilium or flagellum-dependent cell motility (GO:0001539)	4.84364436
15	male meiosis (GO:0007140)	4.82917366
16	reproduction (GO:0000003)	4.65166344
17	regulation of autophagic vacuole assembly (GO:2000785)	4.65098576
18	epithelial cilium movement (GO:0003351)	4.62475299
19	cell-cell recognition (GO:0009988)	4.45601150
20	positive regulation of glycolytic process (GO:0045821)	4.34231553
21	regulation of vacuole organization (GO:0044088)	4.11110647
22	regulation of oxidative stress-induced neuron death (GO:1903203)	4.06033048
23	single fertilization (GO:0007338)	4.01148769
24	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.93807596
25	mitochondrion degradation (GO:0000422)	3.93693813
26	organic cation transport (GO:0015695)	3.92501343
27	cilium movement (GO:0003341)	3.90126299
28	mast cell degranulation (GO:0043303)	3.88570430
29	mast cell activation involved in immune response (GO:0002279)	3.88570430
30	response to pheromone (GO:0019236)	3.87378852
31	potassium ion export (GO:0071435)	3.85096443
32	plasma membrane fusion (GO:0045026)	3.82533540
33	calcium ion-dependent exocytosis (GO:0017156)	3.65110812
34	tongue development (GO:0043586)	3.64774561
35	protein-DNA complex disassembly (GO:0032986)	3.64054037
36	nucleosome disassembly (GO:0006337)	3.64054037
37	germ cell development (GO:0007281)	3.63973363
38	protein polyglutamylation (GO:0018095)	3.58168323
39	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.52483109
40	spermatid nucleus differentiation (GO:0007289)	3.50594360
41	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.47639027
42	activation of protein kinase B activity (GO:0032148)	3.36262517
43	regulation of ARF GTPase activity (GO:0032312)	3.35255312
44	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.35229407
45	relaxation of smooth muscle (GO:0044557)	3.35056432
46	positive regulation of granulocyte differentiation (GO:0030854)	3.22082022
47	cGMP-mediated signaling (GO:0019934)	3.19712106
48	regulation of RIG-I signaling pathway (GO:0039535)	3.18500436
49	polyamine biosynthetic process (GO:0006596)	3.18188700
50	phosphatidylethanolamine metabolic process (GO:0046337)	3.18066019
51	regulation of synaptic transmission, dopaminergic (GO:0032225)	3.15532047
52	sperm capacitation (GO:0048240)	3.14108902
53	negative regulation of reactive oxygen species metabolic process (GO:2000378)	3.11586307
54	mast cell activation (GO:0045576)	3.09029481
55	centriole assembly (GO:0098534)	3.07450818
56	negative regulation of inclusion body assembly (GO:0090084)	3.03051647
57	histone H3-K36 demethylation (GO:0070544)	3.03044247
58	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	3.02266132
59	fertilization (GO:0009566)	3.00415281
60	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.00033784
61	cell wall macromolecule metabolic process (GO:0044036)	2.99187293
62	protein targeting to Golgi (GO:0000042)	2.96693385
63	regulation of granulocyte differentiation (GO:0030852)	2.94264018
64	male sex determination (GO:0030238)	2.93720762
65	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.92632372
66	activated T cell proliferation (GO:0050798)	2.90364791
67	response to acidic pH (GO:0010447)	2.89312728
68	NIK/NF-kappaB signaling (GO:0038061)	2.86818503
69	regulation of oxidative phosphorylation (GO:0002082)	2.86275889
70	rRNA methylation (GO:0031167)	2.85262529
71	L-fucose catabolic process (GO:0042355)	2.83965980
72	fucose catabolic process (GO:0019317)	2.83965980
73	L-fucose metabolic process (GO:0042354)	2.83965980
74	establishment of protein localization to Golgi (GO:0072600)	2.82355639
75	regulation of gamma-delta T cell differentiation (GO:0045586)	2.81666741
76	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.80307373
77	positive regulation of T cell cytokine production (GO:0002726)	2.79608889
78	cofactor catabolic process (GO:0051187)	2.78561319
79	ventricular system development (GO:0021591)	2.78488152
80	regulation of B cell receptor signaling pathway (GO:0050855)	2.77653955
81	synapsis (GO:0007129)	2.77336513
82	genitalia morphogenesis (GO:0035112)	2.75456431
83	regulation of T cell mediated cytotoxicity (GO:0001914)	2.72862550
84	negative regulation of phagocytosis (GO:0050765)	2.72755395
85	spermatogenesis (GO:0007283)	2.70601885
86	cellular extravasation (GO:0045123)	2.69541144
87	male gamete generation (GO:0048232)	2.69204334
88	negative regulation of organelle assembly (GO:1902116)	2.67833668
89	positive regulation of gamma-delta T cell activation (GO:0046645)	2.64658274
90	mRNA cleavage (GO:0006379)	2.63252008
91	DNA double-strand break processing (GO:0000729)	2.62774735
92	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.61105021
93	regulation of gamma-delta T cell activation (GO:0046643)	2.60477520
94	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.59458951
95	diacylglycerol metabolic process (GO:0046339)	2.58040353
96	TOR signaling (GO:0031929)	2.57486587
97	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.57101355
98	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	2.56690866
99	regulation of Rab GTPase activity (GO:0032313)	2.54860492
100	positive regulation of Rab GTPase activity (GO:0032851)	2.54860492

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.88731308
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	6.80260156
3	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	3.18569176
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.95900775
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.64319533
6	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.21762098
7	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.19335100
8	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.13880266
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.01670915
10	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.93757154
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.92068395
12	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.89961758
13	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.89362444
14	NANOG_20526341_ChIP-Seq_ESCs_Human	1.88892959
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.86041577
16	RUNX_20019798_ChIP-Seq_JUKART_Human	1.82554003
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.78370647
18	ERA_21632823_ChIP-Seq_H3396_Human	1.76658106
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.73765024
20	RAC3_21632823_ChIP-Seq_H3396_Human	1.72154019
21	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.69019830
22	OCT4_20526341_ChIP-Seq_ESCs_Human	1.66686619
23	MYB_26560356_Chip-Seq_TH2_Human	1.66338201
24	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.64253542
25	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.58086641
26	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.56730652
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.56542501
28	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.54919636
29	* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.49580431
30	GATA3_27048872_Chip-Seq_THYMUS_Human	1.49547591
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.49173892
32	MAF_26560356_Chip-Seq_TH2_Human	1.48804097
33	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.46805024
34	* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.46398096
35	SMC4_20622854_ChIP-Seq_HELA_Human	1.46232969
36	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.46068180
37	UTX_26944678_Chip-Seq_JUKART_Human	1.43655645
38	BCL6_27268052_Chip-Seq_Bcells_Human	1.43267027
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.41290119
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41290119
41	SPI1_23127762_ChIP-Seq_K562_Human	1.40439238
42	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.39616228
43	MYC_19829295_ChIP-Seq_ESCs_Human	1.38031883
44	SPI1_20517297_ChIP-Seq_HL60_Human	1.37627141
45	DROSHA_22980978_ChIP-Seq_HELA_Human	1.37201789
46	MYB_26560356_Chip-Seq_TH1_Human	1.36483938
47	GATA3_26560356_Chip-Seq_TH2_Human	1.36222416
48	ZNF274_21170338_ChIP-Seq_K562_Hela	1.35880837
49	PHF8_20622854_ChIP-Seq_HELA_Human	1.34110354
50	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.34013468
51	E2F1_20622854_ChIP-Seq_HELA_Human	1.33641109
52	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.30275168
53	CTCF_27219007_Chip-Seq_Bcells_Human	1.28475067
54	P68_20966046_ChIP-Seq_HELA_Human	1.27731312
55	BCOR_27268052_Chip-Seq_Bcells_Human	1.26649678
56	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24736000
57	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.24736000
58	AR_21572438_ChIP-Seq_LNCaP_Human	1.24460645
59	P300_27268052_Chip-Seq_Bcells_Human	1.23789875
60	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.23464121
61	CTCF_20526341_ChIP-Seq_ESCs_Human	1.20193757
62	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.19760943
63	SCL_19346495_ChIP-Seq_HPC-7_Human	1.19055946
64	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.18090348
65	AHR_22903824_ChIP-Seq_MCF-7_Human	1.15669116
66	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.13769955
67	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.10088480
68	VDR_24787735_ChIP-Seq_THP-1_Human	1.08953183
69	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.07819011
70	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.07818097
71	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.07338872
72	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.06660256
73	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06593872
74	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05960436
75	TBL1_22424771_ChIP-Seq_293T_Human	1.05901659
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.05065534
77	KDM2B_26808549_Chip-Seq_DND41_Human	1.04658200
78	GBX2_23144817_ChIP-Seq_PC3_Human	1.03458851
79	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.03351172
80	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.02738557
81	STAT1_20625510_ChIP-Seq_HELA_Human	1.01619619
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.01018760
83	STAT1_17558387_ChIP-Seq_HELA_Human	1.00831083
84	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.99868526
85	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99675950
86	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.99017760
87	ERG_20517297_ChIP-Seq_VCAP_Human	0.98211478
88	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.98026500
89	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.97457291
90	GATA3_26560356_Chip-Seq_TH1_Human	0.95983559
91	PHF8_20622853_ChIP-Seq_HELA_Human	0.95706844
92	LXR_22292898_ChIP-Seq_THP-1_Human	0.95591950
93	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.95224506
94	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.95145760
95	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.95104878
96	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.94224313
97	SPI1_23547873_ChIP-Seq_NB4_Human	0.94110281
98	FUS_26573619_Chip-Seq_HEK293_Human	0.94078912
99	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.94065143
100	NCOR_22424771_ChIP-Seq_293T_Human	0.92249329

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	7.76569355
2	MP0002132_abnormal_respiratory_system	4.02859173
3	MP0008004_abnormal_stomach_pH	3.82108332
4	MP0003315_abnormal_perineum_morphology	2.95443661
5	MP0003698_abnormal_male_reproductive	2.91082097
6	MP0004381_abnormal_hair_follicle	2.72638226
7	MP0001929_abnormal_gametogenesis	2.58172956
8	MP0003724_increased_susceptibility_to	2.33413205
9	MP0003763_abnormal_thymus_physiology	2.32020032
10	MP0005671_abnormal_response_to	2.07200062
11	MP0002160_abnormal_reproductive_system	1.90748163
12	MP0001835_abnormal_antigen_presentation	1.88223859
13	MP0006036_abnormal_mitochondrial_physio	1.86567724
14	MP0001800_abnormal_humoral_immune	1.80541145
15	MP0005360_urolithiasis	1.80234821
16	MP0003045_fibrosis	1.79445696
17	MP0003136_yellow_coat_color	1.71183564
18	MP0005387_immune_system_phenotype	1.68908526
19	MP0001790_abnormal_immune_system	1.68908526
20	MP0002420_abnormal_adaptive_immunity	1.67143415
21	MP0009785_altered_susceptibility_to	1.61654428
22	MP0001819_abnormal_immune_cell	1.60139899
23	MP0005025_abnormal_response_to	1.59795038
24	MP0001501_abnormal_sleep_pattern	1.57709439
25	MP0008260_abnormal_autophagy	1.54803558
26	MP0001905_abnormal_dopamine_level	1.54729745
27	MP0002723_abnormal_immune_serum	1.51852034
28	MP0005377_hearing/vestibular/ear_phenot	1.50387819
29	MP0003878_abnormal_ear_physiology	1.50387819
30	MP0002138_abnormal_hepatobiliary_system	1.47335453
31	MP0003806_abnormal_nucleotide_metabolis	1.45731485
32	MP0002419_abnormal_innate_immunity	1.41852198
33	MP0002161_abnormal_fertility/fecundity	1.40707569
34	MP0000685_abnormal_immune_system	1.40434427
35	MP0005000_abnormal_immune_tolerance	1.37643156
36	MP0003646_muscle_fatigue	1.35538690
37	MP0005058_abnormal_lysosome_morphology	1.34363442
38	MP0000703_abnormal_thymus_morphology	1.31574322
39	MP0002127_abnormal_cardiovascular_syste	1.30043659
40	MP0000716_abnormal_immune_system	1.29191826
41	MP0002398_abnormal_bone_marrow	1.25628705
42	MP0002452_abnormal_antigen_presenting	1.24519860
43	MP0000749_muscle_degeneration	1.23068896
44	MP0002210_abnormal_sex_determination	1.22141483
45	MP0003436_decreased_susceptibility_to	1.21750492
46	MP0004484_altered_response_of	1.21167155
47	MP0000678_abnormal_parathyroid_gland	1.15904793
48	MP0000465_gastrointestinal_hemorrhage	1.11992465
49	MP0005647_abnormal_sex_gland	1.11466715
50	MP0001502_abnormal_circadian_rhythm	1.11195384
51	MP0002722_abnormal_immune_system	1.11019686
52	MP0000653_abnormal_sex_gland	1.10794340
53	MP0002405_respiratory_system_inflammati	1.10077608
54	MP0001145_abnormal_male_reproductive	1.09855677
55	MP0001664_abnormal_digestion	1.06440054
56	MP0006035_abnormal_mitochondrial_morpho	1.05749680
57	MP0001984_abnormal_olfaction	1.05207058
58	MP0008877_abnormal_DNA_methylation	1.02963638
59	MP0002277_abnormal_respiratory_mucosa	1.02903276
60	MP0005166_decreased_susceptibility_to	0.99619736
61	MP0005646_abnormal_pituitary_gland	0.99322717
62	MP0006276_abnormal_autonomic_nervous	0.97825765
63	MP0005075_abnormal_melanosome_morpholog	0.93580057
64	MP0001845_abnormal_inflammatory_respons	0.92042335
65	MP0002429_abnormal_blood_cell	0.91118958
66	MP0000689_abnormal_spleen_morphology	0.90345005
67	MP0005389_reproductive_system_phenotype	0.88385895
68	MP0003303_peritoneal_inflammation	0.87869649
69	MP0004084_abnormal_cardiac_muscle	0.87480145
70	MP0001968_abnormal_touch/_nociception	0.87040906
71	MP0002249_abnormal_larynx_morphology	0.86608851
72	MP0004036_abnormal_muscle_relaxation	0.85757433
73	MP0003172_abnormal_lysosome_physiology	0.84413791
74	MP0009697_abnormal_copulation	0.83932732
75	MP0002148_abnormal_hypersensitivity_rea	0.81541892
76	MP0001873_stomach_inflammation	0.80724970
77	MP0004510_myositis	0.79663583
78	MP0010386_abnormal_urinary_bladder	0.79422180
79	MP0001764_abnormal_homeostasis	0.79105878
80	MP0000015_abnormal_ear_pigmentation	0.78494613
81	MP0002693_abnormal_pancreas_physiology	0.77275068
82	MP0008995_early_reproductive_senescence	0.74704213
83	MP0003787_abnormal_imprinting	0.74428581
84	MP0003936_abnormal_reproductive_system	0.74034623
85	MP0000230_abnormal_systemic_arterial	0.70985534
86	MP0005248_abnormal_Harderian_gland	0.67625325
87	MP0003828_pulmonary_edema	0.67185529
88	MP0005499_abnormal_olfactory_system	0.65972324
89	MP0005394_taste/olfaction_phenotype	0.65972324
90	MP0000470_abnormal_stomach_morphology	0.64858564
91	MP0008874_decreased_physiological_sensi	0.64529496
92	MP0008469_abnormal_protein_level	0.64074612
93	MP0010368_abnormal_lymphatic_system	0.63883767
94	MP0009764_decreased_sensitivity_to	0.63567832
95	MP0001529_abnormal_vocalization	0.63385281
96	MP0000631_abnormal_neuroendocrine_gland	0.62613647
97	MP0001849_ear_inflammation	0.62581064
98	MP0005451_abnormal_body_composition	0.62173912
99	MP0009333_abnormal_splenocyte_physiolog	0.60740071
100	MP0006072_abnormal_retinal_apoptosis	0.60467043

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent/shortened dynein arms (HP:0200106)	5.34503475
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.34503475
3	Resting tremor (HP:0002322)	5.06861802
4	Abnormal ciliary motility (HP:0012262)	4.98251498
5	Abnormal respiratory motile cilium physiology (HP:0012261)	4.83583583
6	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.82324557
7	Sex reversal (HP:0012245)	4.54787861
8	Abnormal sex determination (HP:0012244)	4.54787861
9	Abnormality of the columella (HP:0009929)	4.39149225
10	Abnormal respiratory epithelium morphology (HP:0012253)	4.18855443
11	Abnormal respiratory motile cilium morphology (HP:0005938)	4.18855443
12	Sensory axonal neuropathy (HP:0003390)	3.87497162
13	Colitis (HP:0002583)	3.69833558
14	Nasal polyposis (HP:0100582)	3.68086326
15	Infertility (HP:0000789)	3.65759516
16	Reduced antithrombin III activity (HP:0001976)	3.65644160
17	Inflammation of the large intestine (HP:0002037)	3.34139449
18	Gonadal dysgenesis (HP:0000133)	3.33356542
19	Hypoplasia of the uterus (HP:0000013)	3.29127336
20	Abnormal rod and cone electroretinograms (HP:0008323)	3.21224550
21	Postural instability (HP:0002172)	3.16470346
22	Abnormality of the nasal mucosa (HP:0000433)	3.13595266
23	Gastrointestinal inflammation (HP:0004386)	3.05211383
24	Eosinophilia (HP:0001880)	2.96139279
25	Severe visual impairment (HP:0001141)	2.92866395
26	Male pseudohermaphroditism (HP:0000037)	2.87042423
27	Bronchiectasis (HP:0002110)	2.82390184
28	Thoracic kyphosis (HP:0002942)	2.82251567
29	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.81820630
30	Elevated erythrocyte sedimentation rate (HP:0003565)	2.78748972
31	Cerebellar dysplasia (HP:0007033)	2.77304258
32	Attenuation of retinal blood vessels (HP:0007843)	2.74134626
33	Chronic sinusitis (HP:0011109)	2.67840730
34	Rhinitis (HP:0012384)	2.67456620
35	Granulocytopenia (HP:0001913)	2.67425730
36	Ventricular fibrillation (HP:0001663)	2.63418707
37	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.63311592
38	Retinal atrophy (HP:0001105)	2.61010649
39	Aplasia/hypoplasia of the uterus (HP:0008684)	2.58638502
40	Abnormality of lateral ventricle (HP:0030047)	2.55244752
41	Abnormality of eosinophils (HP:0001879)	2.39827149
42	Type II lissencephaly (HP:0007260)	2.39715114
43	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.35426246
44	Germ cell neoplasia (HP:0100728)	2.33127688
45	Hypoplasia of the thymus (HP:0000778)	2.31902897
46	Chronic obstructive pulmonary disease (HP:0006510)	2.29264172
47	Obstructive lung disease (HP:0006536)	2.29264172
48	Median cleft lip (HP:0000161)	2.25037113
49	Myositis (HP:0100614)	2.24109430
50	Slow saccadic eye movements (HP:0000514)	2.20586105
51	Recurrent corneal erosions (HP:0000495)	2.18029210
52	T lymphocytopenia (HP:0005403)	2.16201661
53	Occipital encephalocele (HP:0002085)	2.14571978
54	Polydipsia (HP:0001959)	2.13135628
55	Abnormal drinking behavior (HP:0030082)	2.13135628
56	Cerebral hypomyelination (HP:0006808)	2.12197516
57	Abnormality of the frontal sinuses (HP:0002687)	2.11111990
58	Pancreatic cysts (HP:0001737)	2.10836296
59	Absent speech (HP:0001344)	2.08200856
60	Exercise-induced myalgia (HP:0003738)	2.08159642
61	Pancreatic fibrosis (HP:0100732)	2.07855462
62	Recurrent fungal infections (HP:0002841)	2.07714983
63	Facial hemangioma (HP:0000329)	2.07346794
64	Meningitis (HP:0001287)	2.06949893
65	Inability to walk (HP:0002540)	2.06094031
66	Atonic seizures (HP:0010819)	2.05119957
67	Self-mutilation (HP:0000742)	2.02589239
68	Recurrent cutaneous fungal infections (HP:0011370)	2.01836101
69	Chronic mucocutaneous candidiasis (HP:0002728)	2.01836101
70	True hermaphroditism (HP:0010459)	1.99139012
71	Abnormality of T cell number (HP:0011839)	1.97989461
72	Thrombocytosis (HP:0001894)	1.95860537
73	Bony spicule pigmentary retinopathy (HP:0007737)	1.90382115
74	Panhypogammaglobulinemia (HP:0003139)	1.88552992
75	Polyneuropathy (HP:0001271)	1.87276392
76	Agammaglobulinemia (HP:0004432)	1.85710896
77	Leukocytosis (HP:0001974)	1.83955675
78	Bile duct proliferation (HP:0001408)	1.83698534
79	Abnormal biliary tract physiology (HP:0012439)	1.83698534
80	Autoimmune hemolytic anemia (HP:0001890)	1.82695371
81	Recurrent sinusitis (HP:0011108)	1.82664091
82	Thoracolumbar scoliosis (HP:0002944)	1.81833242
83	Renal dysplasia (HP:0000110)	1.80386708
84	Cystic liver disease (HP:0006706)	1.80105059
85	Intellectual disability, progressive (HP:0006887)	1.79236158
86	Severe combined immunodeficiency (HP:0004430)	1.78168536
87	Abnormality of dental color (HP:0011073)	1.77783587
88	Recurrent gram-negative bacterial infections (HP:0005420)	1.77726003
89	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.76308666
90	Recurrent skin infections (HP:0001581)	1.73322335
91	Thyroiditis (HP:0100646)	1.72827260
92	Mediastinal lymphadenopathy (HP:0100721)	1.71643592
93	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.71157777
94	Chronic bronchitis (HP:0004469)	1.70728570
95	Ketosis (HP:0001946)	1.70655462
96	Optic nerve hypoplasia (HP:0000609)	1.69215890
97	Clumsiness (HP:0002312)	1.69160145
98	Unsteady gait (HP:0002317)	1.68857670
99	Acute hepatic failure (HP:0006554)	1.68689853
100	Abnormality of DNA repair (HP:0003254)	1.67242025

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	8.75846507
2	MARK3	5.31959919
3	TLK1	3.20742343
4	ZAK	3.11921915
5	MAP4K1	2.46207163
6	MAPKAPK3	2.45088468
7	FES	2.27302472
8	NLK	2.21587797
9	MYLK	1.93295486
10	NEK2	1.92026372
11	MAP3K1	1.70155987
12	RPS6KA5	1.69779278
13	OBSCN	1.67510795
14	STK38	1.67227533
15	LATS1	1.58150195
16	TXK	1.49928146
17	CSNK1G3	1.43438978
18	PRKCQ	1.37167757
19	STK38L	1.30872389
20	MAPK15	1.30395800
21	CSNK1A1L	1.29343352
22	TNK2	1.18205268
23	MAP3K5	1.17219395
24	MAP2K7	1.16887212
25	FRK	1.11097296
26	PIK3CG	1.07180484
27	RIPK4	1.04798283
28	GRK6	1.04629351
29	CSNK1G2	1.03526542
30	BTK	1.03025009
31	TAOK1	1.02328040
32	CSNK1G1	1.01433663
33	SGK223	1.00023166
34	SGK494	1.00023166
35	CDK3	0.98670299
36	MAP3K11	0.97446326
37	TESK2	0.95194239
38	EEF2K	0.94027696
39	PLK4	0.93716538
40	PDK1	0.88798345
41	HCK	0.88280001
42	CSK	0.82967869
43	MAP2K3	0.80622804
44	KDR	0.77654885
45	TAOK2	0.77533270
46	ARAF	0.77509439
47	ZAP70	0.74948404
48	PDPK1	0.73926003
49	SYK	0.73461562
50	MAP3K3	0.71382271
51	MAPK12	0.69864697
52	PRKD3	0.68487184
53	MAP3K13	0.67637346
54	TESK1	0.67372292
55	IRAK4	0.66494087
56	PTK2B	0.65667549
57	ITK	0.61193937
58	MOS	0.60723372
59	BCKDK	0.57241557
60	RPS6KA4	0.56812254
61	CAMK1	0.56224364
62	BLK	0.52190280
63	RPS6KB1	0.52017030
64	MATK	0.50739108
65	ADRBK2	0.49528095
66	MAPK13	0.48433094
67	KIT	0.47547854
68	BMPR1B	0.46982218
69	PKN1	0.46493321
70	LCK	0.46094478
71	MUSK	0.45306699
72	SIK2	0.45116641
73	PRKG1	0.43163355
74	TRPM7	0.40803076
75	PAK1	0.40352060
76	NME2	0.38895783
77	IKBKE	0.38568243
78	SGK2	0.38208200
79	DYRK3	0.37554026
80	TEC	0.36677674
81	PHKG1	0.35341561
82	PHKG2	0.35341561
83	MAP3K7	0.35122530
84	VRK1	0.34231956
85	CDK12	0.33533484
86	MAPK11	0.32333898
87	RPS6KA1	0.31149974
88	MAPKAPK2	0.30733441
89	LYN	0.30213517
90	PRKG2	0.29407645
91	GRK1	0.29118473
92	JAK2	0.28390876
93	MELK	0.25746793
94	TYK2	0.23669551
95	KSR2	0.23144963
96	ROCK1	0.23004804
97	CSNK1A1	0.22632103
98	CAMK4	0.22221768
99	RET	0.21717121
100	MARK2	0.21537990

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	3.99225521
2	Olfactory transduction_Homo sapiens_hsa04740	3.77916795
3	Nitrogen metabolism_Homo sapiens_hsa00910	3.56632746
4	Primary immunodeficiency_Homo sapiens_hsa05340	2.93286687
5	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.30136746
6	Gap junction_Homo sapiens_hsa04540	2.16816336
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.16620766
8	T cell receptor signaling pathway_Homo sapiens_hsa04660	2.06650210
9	Apoptosis_Homo sapiens_hsa04210	2.03597713
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.99944474
11	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.93481571
12	Allograft rejection_Homo sapiens_hsa05330	1.92786703
13	Phagosome_Homo sapiens_hsa04145	1.92626302
14	Phototransduction_Homo sapiens_hsa04744	1.88734143
15	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.88582126
16	Butanoate metabolism_Homo sapiens_hsa00650	1.77059502
17	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.66225958
18	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.65574260
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.57651012
20	Type I diabetes mellitus_Homo sapiens_hsa04940	1.56817777
21	Alcoholism_Homo sapiens_hsa05034	1.55166686
22	Regulation of autophagy_Homo sapiens_hsa04140	1.47755733
23	Circadian rhythm_Homo sapiens_hsa04710	1.40088930
24	Antigen processing and presentation_Homo sapiens_hsa04612	1.37881427
25	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.30543634
26	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.24438389
27	Chemical carcinogenesis_Homo sapiens_hsa05204	1.22195856
28	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.18988958
29	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.17663856
30	Malaria_Homo sapiens_hsa05144	1.15759550
31	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.08335189
32	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.07904058
33	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.05858140
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.05429801
35	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.04687996
36	Renin secretion_Homo sapiens_hsa04924	1.03630804
37	Taste transduction_Homo sapiens_hsa04742	1.03141424
38	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.02548252
39	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.96818244
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.96210422
41	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.95201988
42	Herpes simplex infection_Homo sapiens_hsa05168	0.93757510
43	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.92863097
44	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.91393365
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.89431409
46	Measles_Homo sapiens_hsa05162	0.87917980
47	Propanoate metabolism_Homo sapiens_hsa00640	0.85416036
48	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.85307930
49	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.84437703
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.84183687
51	Circadian entrainment_Homo sapiens_hsa04713	0.84174931
52	Purine metabolism_Homo sapiens_hsa00230	0.83552584
53	Salivary secretion_Homo sapiens_hsa04970	0.82959672
54	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.81953026
55	Gastric acid secretion_Homo sapiens_hsa04971	0.81668592
56	Calcium signaling pathway_Homo sapiens_hsa04020	0.77398685
57	Glucagon signaling pathway_Homo sapiens_hsa04922	0.75727476
58	Osteoclast differentiation_Homo sapiens_hsa04380	0.73835558
59	Acute myeloid leukemia_Homo sapiens_hsa05221	0.73024257
60	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.69798005
61	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.69696858
62	Platelet activation_Homo sapiens_hsa04611	0.68969414
63	Tuberculosis_Homo sapiens_hsa05152	0.66711022
64	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.65022159
65	MAPK signaling pathway_Homo sapiens_hsa04010	0.63628556
66	Arginine biosynthesis_Homo sapiens_hsa00220	0.62204882
67	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.61549383
68	Leishmaniasis_Homo sapiens_hsa05140	0.60793061
69	Oocyte meiosis_Homo sapiens_hsa04114	0.60627770
70	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.59259509
71	Chemokine signaling pathway_Homo sapiens_hsa04062	0.55728257
72	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.54827442
73	Viral myocarditis_Homo sapiens_hsa05416	0.54010439
74	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.52698042
75	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.52274094
76	FoxO signaling pathway_Homo sapiens_hsa04068	0.51733171
77	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48014074
78	PPAR signaling pathway_Homo sapiens_hsa03320	0.46256551
79	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.45910042
80	Viral carcinogenesis_Homo sapiens_hsa05203	0.45856033
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43026740
82	Fatty acid degradation_Homo sapiens_hsa00071	0.42686919
83	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.41573533
84	Fanconi anemia pathway_Homo sapiens_hsa03460	0.41238117
85	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.40798992
86	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.39841935
87	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.39635698
88	Endometrial cancer_Homo sapiens_hsa05213	0.39291022
89	Basal transcription factors_Homo sapiens_hsa03022	0.39235074
90	Long-term potentiation_Homo sapiens_hsa04720	0.38431962
91	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.38305084
92	Phenylalanine metabolism_Homo sapiens_hsa00360	0.37484239
93	Asthma_Homo sapiens_hsa05310	0.36807169
94	Peroxisome_Homo sapiens_hsa04146	0.36142560
95	cAMP signaling pathway_Homo sapiens_hsa04024	0.34644658
96	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.33889094
97	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.33518515
98	Influenza A_Homo sapiens_hsa05164	0.33393834
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.31203193
100	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.30633571

LINC00264

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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