ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein-cofactor linkage (GO:0018065)	5.83882950
2	piRNA metabolic process (GO:0034587)	5.15048745
3	protein K6-linked ubiquitination (GO:0085020)	5.05972749
4	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	5.01588790
5	regulation of meiosis I (GO:0060631)	4.58739156
6	estrogen biosynthetic process (GO:0006703)	4.47869702
7	response to pheromone (GO:0019236)	4.36650187
8	male meiosis (GO:0007140)	4.30099529
9	rRNA catabolic process (GO:0016075)	4.26048314
10	leukotriene biosynthetic process (GO:0019370)	4.22638722
11	CENP-A containing nucleosome assembly (GO:0034080)	4.08596016
12	chromatin remodeling at centromere (GO:0031055)	4.07182249
13	meiosis I (GO:0007127)	4.06070484
14	single strand break repair (GO:0000012)	4.05551591
15	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	4.03157266
16	male meiosis I (GO:0007141)	4.01454744
17	histone exchange (GO:0043486)	4.00268516
18	negative regulation of DNA-templated transcription, elongation (GO:0032785)	3.97216413
19	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.91474112
20	epithelial cilium movement (GO:0003351)	3.89533322
21	synaptonemal complex assembly (GO:0007130)	3.83947692
22	DNA methylation involved in gamete generation (GO:0043046)	3.83078511
23	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.82393724
24	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.81657670
25	synapsis (GO:0007129)	3.80673530
26	ribosome assembly (GO:0042255)	3.78938435
27	protein K11-linked deubiquitination (GO:0035871)	3.68591633
28	regulation of germinal center formation (GO:0002634)	3.68231388
29	negative regulation of meiosis (GO:0045835)	3.67614095
30	positive regulation of prostaglandin secretion (GO:0032308)	3.66752120
31	chromosome organization involved in meiosis (GO:0070192)	3.64986286
32	embryonic foregut morphogenesis (GO:0048617)	3.60019845
33	multicellular organism reproduction (GO:0032504)	3.58657159
34	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.57384555
35	establishment of monopolar cell polarity (GO:0061162)	3.57384555
36	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.55947961
37	regulation of mitotic spindle checkpoint (GO:1903504)	3.55947961
38	sperm-egg recognition (GO:0035036)	3.53601772
39	positive regulation of mitochondrial fission (GO:0090141)	3.50906736
40	transcription from mitochondrial promoter (GO:0006390)	3.50041978
41	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.49911826
42	phosphatidylethanolamine metabolic process (GO:0046337)	3.41281130
43	histone H2A acetylation (GO:0043968)	3.41000761
44	protein neddylation (GO:0045116)	3.35084767
45	synaptonemal complex organization (GO:0070193)	3.34983793
46	negative regulation of meiotic cell cycle (GO:0051447)	3.18104455
47	peptidyl-arginine omega-N-methylation (GO:0035247)	3.10496285
48	spermatid development (GO:0007286)	3.10187762
49	rRNA methylation (GO:0031167)	3.00636075
50	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.00418367
51	meiotic nuclear division (GO:0007126)	2.98535088
52	binding of sperm to zona pellucida (GO:0007339)	2.98357441
53	negative regulation of DNA recombination (GO:0045910)	2.95531313
54	protein polyglutamylation (GO:0018095)	2.94320590
55	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.93517960
56	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.93517960
57	methionine metabolic process (GO:0006555)	2.93511942
58	cell-cell recognition (GO:0009988)	2.92497694
59	regulation of prostaglandin secretion (GO:0032306)	2.92471032
60	methionine biosynthetic process (GO:0009086)	2.91825229
61	protein K63-linked ubiquitination (GO:0070534)	2.88689754
62	dopamine transport (GO:0015872)	2.88542337
63	establishment of apical/basal cell polarity (GO:0035089)	2.88408502
64	glutathione biosynthetic process (GO:0006750)	2.83205460
65	histone arginine methylation (GO:0034969)	2.80749058
66	sperm motility (GO:0030317)	2.80347713
67	mitochondrial DNA replication (GO:0006264)	2.79437064
68	positive regulation of mRNA processing (GO:0050685)	2.78432516
69	negative regulation of viral transcription (GO:0032897)	2.78256144
70	myelin assembly (GO:0032288)	2.76973393
71	microtubule depolymerization (GO:0007019)	2.76585357
72	cilium movement (GO:0003341)	2.74797557
73	DNA double-strand break processing (GO:0000729)	2.74621654
74	regulation of cilium movement (GO:0003352)	2.74529483
75	intraciliary transport (GO:0042073)	2.74439289
76	ncRNA catabolic process (GO:0034661)	2.74080203
77	mannosylation (GO:0097502)	2.73198487
78	peptidyl-histidine modification (GO:0018202)	2.71770522
79	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.71156604
80	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.71087520
81	pancreas development (GO:0031016)	2.70387235
82	reciprocal meiotic recombination (GO:0007131)	2.70355030
83	reciprocal DNA recombination (GO:0035825)	2.70355030
84	nonribosomal peptide biosynthetic process (GO:0019184)	2.69095789
85	rRNA modification (GO:0000154)	2.67222916
86	respiratory chain complex IV assembly (GO:0008535)	2.65685435
87	axonemal dynein complex assembly (GO:0070286)	2.65104109
88	peptidyl-arginine methylation (GO:0018216)	2.64526130
89	peptidyl-arginine N-methylation (GO:0035246)	2.64526130
90	negative regulation of viral release from host cell (GO:1902187)	2.64515499
91	magnesium ion transport (GO:0015693)	2.62861073
92	DNA catabolic process, exonucleolytic (GO:0000738)	2.62838809
93	DNA replication-independent nucleosome assembly (GO:0006336)	2.62736013
94	DNA replication-independent nucleosome organization (GO:0034724)	2.62736013
95	regulation of helicase activity (GO:0051095)	2.60993060
96	DNA deamination (GO:0045006)	2.60883873
97	gastrulation with mouth forming second (GO:0001702)	2.58586889
98	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.58443741
99	cellular response to interleukin-15 (GO:0071350)	2.57244576
100	DNA replication checkpoint (GO:0000076)	2.53780323

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA1_22025678_ChIP-Seq_K562_Human	5.57167340
2	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	4.12108654
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.75397089
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.60266794
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.40917957
6	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.13729832
7	ZNF274_21170338_ChIP-Seq_K562_Hela	3.06036283
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.76719401
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.52318243
10	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.46997032
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.42121507
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.40183286
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.29687789
14	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.27483603
15	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.24178852
16	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.21733130
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.20979286
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.16432532
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14589345
20	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.00764218
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.85519662
22	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.84876295
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.83020119
24	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.82138863
25	IGF1R_20145208_ChIP-Seq_DFB_Human	1.81562434
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.74834722
27	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.70774876
28	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.68420616
29	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.61078911
30	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.58567462
31	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.54810028
32	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.53919823
33	FOXP3_21729870_ChIP-Seq_TREG_Human	1.52383988
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.48028314
35	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.44709615
36	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.43267450
37	TAF15_26573619_Chip-Seq_HEK293_Human	1.42158286
38	NCOR_22424771_ChIP-Seq_293T_Human	1.41650915
39	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.38738461
40	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.37795850
41	EWS_26573619_Chip-Seq_HEK293_Human	1.31694824
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.31087667
43	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.29332561
44	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.28519255
45	VDR_22108803_ChIP-Seq_LS180_Human	1.28273164
46	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.24611619
47	GABP_19822575_ChIP-Seq_HepG2_Human	1.24526899
48	TTF2_22483619_ChIP-Seq_HELA_Human	1.22999947
49	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.19871187
50	NANOG_20526341_ChIP-Seq_ESCs_Human	1.19731204
51	DCP1A_22483619_ChIP-Seq_HELA_Human	1.19392635
52	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.18257843
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.17296780
54	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.16969944
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.15557845
56	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15557845
57	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.15230612
58	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.13929742
59	ERG_20517297_ChIP-Seq_VCAP_Human	1.13092655
60	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.12217959
61	TP53_22573176_ChIP-Seq_HFKS_Human	1.11967233
62	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.10436113
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09454547
64	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.09365116
65	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09169098
66	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.08984095
67	KDM5A_27292631_Chip-Seq_BREAST_Human	1.08753174
68	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.07968505
69	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.07279078
70	MYC_19829295_ChIP-Seq_ESCs_Human	1.05942337
71	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.03640817
72	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03473992
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03390805
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03390805
75	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02723091
76	FUS_26573619_Chip-Seq_HEK293_Human	1.02678257
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02304864
78	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.02082859
79	P300_19829295_ChIP-Seq_ESCs_Human	0.99023314
80	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.97146414
81	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.96529037
82	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.95780887
83	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.94666712
84	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.94636697
85	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.93795644
86	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.92882302
87	ERA_21632823_ChIP-Seq_H3396_Human	0.92313423
88	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90840649
89	GATA3_26560356_Chip-Seq_TH1_Human	0.90426045
90	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.90280881
91	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.89999225
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.89597816
93	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.89434184
94	CBP_20019798_ChIP-Seq_JUKART_Human	0.89394349
95	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.89394349
96	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.89314971
97	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.87427727
98	E2F7_22180533_ChIP-Seq_HELA_Human	0.86487884
99	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.85544528
100	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.85296268

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003011_delayed_dark_adaptation	5.74750943
2	MP0008877_abnormal_DNA_methylation	4.22286851
3	MP0003195_calcinosis	3.85939781
4	MP0000013_abnormal_adipose_tissue	3.45868721
5	MP0010094_abnormal_chromosome_stability	2.94025544
6	MP0005645_abnormal_hypothalamus_physiol	2.76069398
7	MP0008995_early_reproductive_senescence	2.72805018
8	MP0003763_abnormal_thymus_physiology	2.70858387
9	MP0004133_heterotaxia	2.59851922
10	MP0005410_abnormal_fertilization	2.27092561
11	MP0002102_abnormal_ear_morphology	2.19048880
12	MP0001529_abnormal_vocalization	2.16444207
13	MP0002277_abnormal_respiratory_mucosa	2.14115760
14	MP0008789_abnormal_olfactory_epithelium	2.13424567
15	MP0005671_abnormal_response_to	2.09712507
16	MP0001929_abnormal_gametogenesis	2.07611107
17	MP0002210_abnormal_sex_determination	1.92863386
18	MP0008058_abnormal_DNA_repair	1.91966613
19	MP0003698_abnormal_male_reproductive	1.88384528
20	MP0003786_premature_aging	1.81051049
21	MP0002009_preneoplasia	1.78811265
22	MP0002736_abnormal_nociception_after	1.78717232
23	MP0003693_abnormal_embryo_hatching	1.70042929
24	MP0002653_abnormal_ependyma_morphology	1.61468405
25	MP0006072_abnormal_retinal_apoptosis	1.60863615
26	MP0005253_abnormal_eye_physiology	1.60452050
27	MP0005167_abnormal_blood-brain_barrier	1.60367140
28	MP0003787_abnormal_imprinting	1.60007054
29	MP0001968_abnormal_touch/_nociception	1.57870331
30	MP0003111_abnormal_nucleus_morphology	1.54496641
31	MP0002166_altered_tumor_susceptibility	1.53609925
32	MP0001145_abnormal_male_reproductive	1.48735669
33	MP0006292_abnormal_olfactory_placode	1.46555578
34	MP0005499_abnormal_olfactory_system	1.46550724
35	MP0005394_taste/olfaction_phenotype	1.46550724
36	MP0005646_abnormal_pituitary_gland	1.44052112
37	MP0006036_abnormal_mitochondrial_physio	1.39863676
38	MP0002006_tumorigenesis	1.37822046
39	MP0000653_abnormal_sex_gland	1.33698042
40	MP0003077_abnormal_cell_cycle	1.33639675
41	MP0003943_abnormal_hepatobiliary_system	1.31037501
42	MP0002751_abnormal_autonomic_nervous	1.30735741
43	MP0001919_abnormal_reproductive_system	1.28541614
44	MP0005379_endocrine/exocrine_gland_phen	1.26047134
45	MP0008872_abnormal_physiological_respon	1.25457707
46	MP0004742_abnormal_vestibular_system	1.23341142
47	MP0009785_altered_susceptibility_to	1.22007566
48	MP0001119_abnormal_female_reproductive	1.21331491
49	MP0008932_abnormal_embryonic_tissue	1.17183017
50	MP0002254_reproductive_system_inflammat	1.13517485
51	MP0005389_reproductive_system_phenotype	1.11863563
52	MP0000631_abnormal_neuroendocrine_gland	1.11804126
53	MP0001835_abnormal_antigen_presentation	1.08527616
54	MP0002933_joint_inflammation	1.06646479
55	MP0004885_abnormal_endolymph	1.03452489
56	MP0005075_abnormal_melanosome_morpholog	1.00271617
57	MP0004147_increased_porphyrin_level	0.99555754
58	MP0000049_abnormal_middle_ear	0.99504932
59	MP0001800_abnormal_humoral_immune	0.97930106
60	MP0005647_abnormal_sex_gland	0.97745113
61	MP0002163_abnormal_gland_morphology	0.96734382
62	MP0002161_abnormal_fertility/fecundity	0.93608136
63	MP0003938_abnormal_ear_development	0.92693159
64	MP0003718_maternal_effect	0.91786953
65	MP0008057_abnormal_DNA_replication	0.91670709
66	MP0010307_abnormal_tumor_latency	0.87776384
67	MP0000685_abnormal_immune_system	0.87461804
68	MP0002723_abnormal_immune_serum	0.84733843
69	MP0000689_abnormal_spleen_morphology	0.84422315
70	MP0002234_abnormal_pharynx_morphology	0.84022224
71	MP0004264_abnormal_extraembryonic_tissu	0.83654237
72	MP0001324_abnormal_eye_pigmentation	0.81832066
73	MP0005387_immune_system_phenotype	0.81389330
74	MP0001790_abnormal_immune_system	0.81389330
75	MP0002876_abnormal_thyroid_physiology	0.81031283
76	MP0005000_abnormal_immune_tolerance	0.80799169
77	MP0002160_abnormal_reproductive_system	0.80638958
78	MP0000613_abnormal_salivary_gland	0.79454368
79	MP0002697_abnormal_eye_size	0.78519440
80	MP0003699_abnormal_female_reproductive	0.75701189
81	MP0001986_abnormal_taste_sensitivity	0.74335456
82	MP0003724_increased_susceptibility_to	0.74006980
83	MP0009333_abnormal_splenocyte_physiolog	0.73871361
84	MP0001286_abnormal_eye_development	0.73786902
85	MP0003936_abnormal_reproductive_system	0.73566324
86	MP0003646_muscle_fatigue	0.73003309
87	MP0003880_abnormal_central_pattern	0.71887617
88	MP0004957_abnormal_blastocyst_morpholog	0.70236060
89	MP0005377_hearing/vestibular/ear_phenot	0.69780895
90	MP0003878_abnormal_ear_physiology	0.69780895
91	MP0009745_abnormal_behavioral_response	0.69101233
92	MP0005551_abnormal_eye_electrophysiolog	0.68919927
93	MP0002229_neurodegeneration	0.67561302
94	MP0003283_abnormal_digestive_organ	0.67115200
95	MP0000639_abnormal_adrenal_gland	0.65421486
96	MP0004134_abnormal_chest_morphology	0.63257021
97	MP0010386_abnormal_urinary_bladder	0.62502606
98	MP0001905_abnormal_dopamine_level	0.62354737
99	MP0002398_abnormal_bone_marrow	0.61708814
100	MP0001819_abnormal_immune_cell	0.60106484

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Neuroendocrine neoplasm (HP:0100634)	4.26705424
2	Meckel diverticulum (HP:0002245)	3.92913770
3	Abnormality of the ileum (HP:0001549)	3.72177317
4	Severe visual impairment (HP:0001141)	3.60668907
5	Intestinal atresia (HP:0011100)	3.52527624
6	Abnormality of homocysteine metabolism (HP:0010919)	3.42624242
7	Homocystinuria (HP:0002156)	3.42624242
8	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.22211645
9	Abnormality of the labia minora (HP:0012880)	3.06671500
10	Small intestinal stenosis (HP:0012848)	2.97924622
11	Duodenal stenosis (HP:0100867)	2.97924622
12	T lymphocytopenia (HP:0005403)	2.90947190
13	Retinal dysplasia (HP:0007973)	2.84341696
14	Type II lissencephaly (HP:0007260)	2.81746101
15	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.79233871
16	Absent/shortened dynein arms (HP:0200106)	2.79233871
17	Tubulointerstitial nephritis (HP:0001970)	2.74566114
18	Rhabdomyosarcoma (HP:0002859)	2.73379329
19	Abnormality of the vocal cords (HP:0008777)	2.68730609
20	Abnormality of the parathyroid morphology (HP:0011766)	2.66156296
21	Hyperglycinemia (HP:0002154)	2.64248304
22	Metabolic alkalosis (HP:0200114)	2.55810079
23	Abnormal biliary tract physiology (HP:0012439)	2.53826215
24	Bile duct proliferation (HP:0001408)	2.53826215
25	Abnormal respiratory epithelium morphology (HP:0012253)	2.53095170
26	Abnormal respiratory motile cilium morphology (HP:0005938)	2.53095170
27	Congenital stationary night blindness (HP:0007642)	2.52772745
28	Neoplasm of the peripheral nervous system (HP:0100007)	2.52661667
29	Abnormality of the duodenum (HP:0002246)	2.51938161
30	Pheochromocytoma (HP:0002666)	2.47862509
31	Pancreatic cysts (HP:0001737)	2.45023753
32	Severe combined immunodeficiency (HP:0004430)	2.40828370
33	Abnormality of the preputium (HP:0100587)	2.40754885
34	Abnormality of the renal cortex (HP:0011035)	2.40557218
35	Combined immunodeficiency (HP:0005387)	2.39168852
36	Prostate neoplasm (HP:0100787)	2.37391046
37	Hypokalemic alkalosis (HP:0001949)	2.37370063
38	Anterior segment dysgenesis (HP:0007700)	2.35114889
39	Abnormality of T cell number (HP:0011839)	2.31936912
40	Renal cortical cysts (HP:0000803)	2.31857985
41	Carpal bone hypoplasia (HP:0001498)	2.26237004
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.25667941
43	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.24197770
44	Panhypogammaglobulinemia (HP:0003139)	2.23537232
45	Colon cancer (HP:0003003)	2.22339319
46	Optic nerve hypoplasia (HP:0000609)	2.22286715
47	Clubbing of toes (HP:0100760)	2.21513389
48	Abnormal ciliary motility (HP:0012262)	2.19074220
49	Pachygyria (HP:0001302)	2.18246953
50	Pustule (HP:0200039)	2.17878833
51	Megaloblastic anemia (HP:0001889)	2.17038792
52	Abnormality of chromosome stability (HP:0003220)	2.16294692
53	Pendular nystagmus (HP:0012043)	2.16089943
54	Shoulder girdle muscle weakness (HP:0003547)	2.14730864
55	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.14463630
56	Secondary amenorrhea (HP:0000869)	2.13883233
57	Abnormality of the renal medulla (HP:0100957)	2.13688081
58	Lissencephaly (HP:0001339)	2.13272519
59	Abnormality of midbrain morphology (HP:0002418)	2.12945019
60	Molar tooth sign on MRI (HP:0002419)	2.12945019
61	True hermaphroditism (HP:0010459)	2.12042837
62	Abnormal spermatogenesis (HP:0008669)	2.11732584
63	Abnormality of serum amino acid levels (HP:0003112)	2.11560964
64	Abnormality of vitamin B metabolism (HP:0004340)	2.10903657
65	Impulsivity (HP:0100710)	2.10541135
66	Optic nerve coloboma (HP:0000588)	2.09534789
67	IgG deficiency (HP:0004315)	2.08667830
68	Recurrent cutaneous fungal infections (HP:0011370)	2.08050511
69	Chronic mucocutaneous candidiasis (HP:0002728)	2.08050511
70	Rhinitis (HP:0012384)	2.07924287
71	Rimmed vacuoles (HP:0003805)	2.07334873
72	Attenuation of retinal blood vessels (HP:0007843)	2.04580167
73	Infertility (HP:0000789)	2.03883177
74	Abnormality of T cells (HP:0002843)	2.00005892
75	Pancreatic fibrosis (HP:0100732)	1.99562424
76	Asplenia (HP:0001746)	1.97491875
77	Gonadotropin excess (HP:0000837)	1.94826086
78	Anencephaly (HP:0002323)	1.94194042
79	Nephronophthisis (HP:0000090)	1.93754570
80	Supernumerary spleens (HP:0009799)	1.92756524
81	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.92620066
82	Hyperglycinuria (HP:0003108)	1.90398682
83	Acute necrotizing encephalopathy (HP:0006965)	1.90287322
84	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.87141876
85	Chromsome breakage (HP:0040012)	1.85916240
86	Abnormal lung lobation (HP:0002101)	1.85260408
87	Optic disc pallor (HP:0000543)	1.84072545
88	Tubulointerstitial abnormality (HP:0001969)	1.81320587
89	Abnormality of macular pigmentation (HP:0008002)	1.81278782
90	Tubular atrophy (HP:0000092)	1.80800327
91	Abnormality of the pulmonary veins (HP:0011718)	1.80713424
92	Inability to walk (HP:0002540)	1.80536251
93	Abnormal respiratory motile cilium physiology (HP:0012261)	1.78614621
94	Inflammation of the large intestine (HP:0002037)	1.76470466
95	Neonatal respiratory distress (HP:0002643)	1.76451898
96	Abnormality of T cell physiology (HP:0011840)	1.76159738
97	Mitochondrial inheritance (HP:0001427)	1.75888018
98	Abnormality of methionine metabolism (HP:0010901)	1.75544234
99	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.75485302
100	Gastrointestinal atresia (HP:0002589)	1.73830986

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.87490736
2	ZAK	4.27955229
3	WNK3	3.95365135
4	TAOK3	3.47061538
5	CDC7	3.22848843
6	MAP2K2	2.76811513
7	NUAK1	2.73164756
8	PINK1	2.68854456
9	TSSK6	2.66223689
10	BUB1	2.41615697
11	TLK1	2.02583700
12	ACVR1B	1.91615682
13	TTK	1.90077503
14	CDK19	1.88892904
15	TRIM28	1.88877552
16	MAP3K14	1.81871917
17	CSF1R	1.77143299
18	VRK2	1.69711320
19	PLK4	1.66168769
20	MAP4K2	1.60792451
21	ADRBK2	1.58650125
22	TAF1	1.52214630
23	DYRK2	1.51611886
24	KIT	1.43484714
25	TESK2	1.40564834
26	IKBKB	1.34728698
27	PNCK	1.33190408
28	IKBKE	1.30236889
29	DYRK3	1.15026579
30	EIF2AK2	1.13534096
31	WNK4	1.12178076
32	OXSR1	1.06187109
33	PLK3	1.04132525
34	PASK	1.02867264
35	TYK2	1.02404154
36	EIF2AK3	0.97895871
37	MAP3K4	0.96109555
38	CDK3	0.95992490
39	TBK1	0.90408034
40	JAK1	0.90287328
41	INSRR	0.86619222
42	PLK1	0.85913424
43	BCR	0.85678846
44	BRSK2	0.82664827
45	CHUK	0.80597418
46	DYRK1A	0.77578277
47	BRD4	0.76393112
48	VRK1	0.73136831
49	STK11	0.70749490
50	LIMK1	0.69897694
51	AURKB	0.67755411
52	GRK1	0.67582672
53	STK39	0.67069865
54	ATR	0.66773019
55	NME1	0.66639437
56	TESK1	0.66211207
57	CASK	0.64403934
58	MATK	0.63778452
59	PRKCQ	0.63726153
60	EPHA4	0.63336821
61	LCK	0.62171982
62	FES	0.61976018
63	MST4	0.61895954
64	CLK1	0.60662366
65	FGR	0.59452834
66	KDR	0.58618147
67	SRPK1	0.58603085
68	MAP4K1	0.57403297
69	MINK1	0.57156275
70	CHEK2	0.54769260
71	STK10	0.54518662
72	DYRK1B	0.53891424
73	EPHB2	0.53870203
74	RPS6KA5	0.51596813
75	ATM	0.50559657
76	MAPK11	0.49547069
77	IGF1R	0.47052748
78	MAPK13	0.46098838
79	ALK	0.45421074
80	MARK3	0.44345083
81	WEE1	0.44303047
82	RPS6KA1	0.43722828
83	MAP2K7	0.43699953
84	SIK2	0.42864015
85	ABL1	0.41791448
86	MAPK4	0.41653835
87	CSNK1G1	0.39289324
88	NTRK3	0.37041398
89	CCNB1	0.36156039
90	BMPR1B	0.35863957
91	AURKA	0.33645153
92	CSNK2A1	0.31802550
93	ADRBK1	0.31532497
94	SYK	0.30693108
95	TEC	0.30103276
96	PRKD2	0.28866784
97	FYN	0.28271093
98	CHEK1	0.27698625
99	TGFBR1	0.26248111
100	LYN	0.25719942

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	5.02466019
2	One carbon pool by folate_Homo sapiens_hsa00670	3.45397964
3	Selenocompound metabolism_Homo sapiens_hsa00450	3.36033825
4	Mismatch repair_Homo sapiens_hsa03430	2.92247926
5	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.74956202
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.66648405
7	Proteasome_Homo sapiens_hsa03050	2.62559189
8	Homologous recombination_Homo sapiens_hsa03440	2.59758574
9	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.50151716
10	Primary immunodeficiency_Homo sapiens_hsa05340	2.43729775
11	Basal transcription factors_Homo sapiens_hsa03022	2.39448393
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.25832073
13	Fatty acid elongation_Homo sapiens_hsa00062	2.17886106
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.92562899
15	RNA degradation_Homo sapiens_hsa03018	1.85048140
16	RNA polymerase_Homo sapiens_hsa03020	1.79554786
17	DNA replication_Homo sapiens_hsa03030	1.78974478
18	Butanoate metabolism_Homo sapiens_hsa00650	1.76764362
19	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.71058519
20	Parkinsons disease_Homo sapiens_hsa05012	1.69533945
21	beta-Alanine metabolism_Homo sapiens_hsa00410	1.64474570
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.57477317
23	Ribosome_Homo sapiens_hsa03010	1.50430281
24	Base excision repair_Homo sapiens_hsa03410	1.49873413
25	Protein export_Homo sapiens_hsa03060	1.45286207
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.32430671
27	Spliceosome_Homo sapiens_hsa03040	1.30870776
28	Antigen processing and presentation_Homo sapiens_hsa04612	1.23105404
29	Phototransduction_Homo sapiens_hsa04744	1.22709235
30	RNA transport_Homo sapiens_hsa03013	1.14355548
31	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.13243346
32	Regulation of autophagy_Homo sapiens_hsa04140	1.11665965
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.09955636
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.09746581
35	Huntingtons disease_Homo sapiens_hsa05016	1.07054305
36	Folate biosynthesis_Homo sapiens_hsa00790	1.06728051
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.05898467
38	Retinol metabolism_Homo sapiens_hsa00830	1.02969819
39	Pyrimidine metabolism_Homo sapiens_hsa00240	1.01490099
40	Legionellosis_Homo sapiens_hsa05134	0.98219169
41	Rheumatoid arthritis_Homo sapiens_hsa05323	0.98081402
42	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.93579209
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.89617725
44	Nucleotide excision repair_Homo sapiens_hsa03420	0.88626540
45	Cell cycle_Homo sapiens_hsa04110	0.85924402
46	Purine metabolism_Homo sapiens_hsa00230	0.85217850
47	p53 signaling pathway_Homo sapiens_hsa04115	0.80978772
48	Caffeine metabolism_Homo sapiens_hsa00232	0.79388395
49	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.77702756
50	Tryptophan metabolism_Homo sapiens_hsa00380	0.76121678
51	Graft-versus-host disease_Homo sapiens_hsa05332	0.75825477
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.75041965
53	Circadian rhythm_Homo sapiens_hsa04710	0.74934106
54	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.73153308
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.73009672
56	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.72654845
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.70885663
58	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.70838261
59	Non-homologous end-joining_Homo sapiens_hsa03450	0.68170660
60	Fatty acid degradation_Homo sapiens_hsa00071	0.68023601
61	Nitrogen metabolism_Homo sapiens_hsa00910	0.67413013
62	Type I diabetes mellitus_Homo sapiens_hsa04940	0.66753691
63	Herpes simplex infection_Homo sapiens_hsa05168	0.65266949
64	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.64474815
65	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.64339536
66	Propanoate metabolism_Homo sapiens_hsa00640	0.62789225
67	Alzheimers disease_Homo sapiens_hsa05010	0.58362348
68	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.57578863
69	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.57432696
70	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.56926798
71	Allograft rejection_Homo sapiens_hsa05330	0.55437662
72	Olfactory transduction_Homo sapiens_hsa04740	0.54280452
73	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.54254557
74	Lysine degradation_Homo sapiens_hsa00310	0.54046761
75	Ether lipid metabolism_Homo sapiens_hsa00565	0.52965632
76	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.52727246
77	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.50980637
78	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.50752981
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.50431041
80	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.50181451
81	Metabolic pathways_Homo sapiens_hsa01100	0.50045772
82	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.48336218
83	mRNA surveillance pathway_Homo sapiens_hsa03015	0.46099827
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45653043
85	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.42274210
86	Viral myocarditis_Homo sapiens_hsa05416	0.40306607
87	Peroxisome_Homo sapiens_hsa04146	0.35371104
88	ABC transporters_Homo sapiens_hsa02010	0.34817702
89	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.34715353
90	Measles_Homo sapiens_hsa05162	0.34119960
91	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.32654490
92	Chemical carcinogenesis_Homo sapiens_hsa05204	0.29698706
93	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.25866487
94	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.22477310
95	Asthma_Homo sapiens_hsa05310	0.22275866
96	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.21746110
97	Renin-angiotensin system_Homo sapiens_hsa04614	0.20540720
98	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.20303188
99	Oocyte meiosis_Homo sapiens_hsa04114	0.17398047
100	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.16083671

LINC00265-2P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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