ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of posttranscriptional gene silencing (GO:0060147)	7.46415357
2	regulation of gene silencing by miRNA (GO:0060964)	7.46415357
3	regulation of gene silencing by RNA (GO:0060966)	7.46415357
4	establishment of integrated proviral latency (GO:0075713)	5.68051474
5	pre-miRNA processing (GO:0031054)	5.50292064
6	positive regulation of SMAD protein import into nucleus (GO:0060391)	5.00826290
7	L-serine metabolic process (GO:0006563)	4.98598618
8	heterochromatin organization (GO:0070828)	4.70791859
9	protein localization to kinetochore (GO:0034501)	4.64858521
10	protein complex localization (GO:0031503)	4.60010236
11	regulation of cell fate specification (GO:0042659)	4.40460958
12	IMP biosynthetic process (GO:0006188)	4.37149955
13	regulation of helicase activity (GO:0051095)	4.26306083
14	establishment of viral latency (GO:0019043)	4.21256916
15	chromatin remodeling at centromere (GO:0031055)	4.20137725
16	negative regulation of gene silencing (GO:0060969)	4.14459553
17	paraxial mesoderm development (GO:0048339)	4.11329808
18	regulation of histone H3-K9 methylation (GO:0051570)	4.10463461
19	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	4.09757958
20	CENP-A containing nucleosome assembly (GO:0034080)	4.09299144
21	DNA unwinding involved in DNA replication (GO:0006268)	4.08672250
22	regulation of gene silencing (GO:0060968)	4.07396734
23	IMP metabolic process (GO:0046040)	4.04648351
24	L-alpha-amino acid transmembrane transport (GO:1902475)	3.95830403
25	DNA strand elongation involved in DNA replication (GO:0006271)	3.89667299
26	cell fate commitment involved in formation of primary germ layer (GO:0060795)	3.86387549
27	DNA replication-dependent nucleosome organization (GO:0034723)	3.85053017
28	DNA replication-dependent nucleosome assembly (GO:0006335)	3.85053017
29	DNA replication checkpoint (GO:0000076)	3.83145018
30	regulation of chromatin silencing (GO:0031935)	3.82917443
31	mitotic metaphase plate congression (GO:0007080)	3.82619576
32	nuclear pore complex assembly (GO:0051292)	3.82222445
33	histone exchange (GO:0043486)	3.79026443
34	histone arginine methylation (GO:0034969)	3.73653255
35	DNA strand elongation (GO:0022616)	3.69413487
36	protein localization to chromosome, centromeric region (GO:0071459)	3.69369705
37	DNA replication-independent nucleosome organization (GO:0034724)	3.68942802
38	DNA replication-independent nucleosome assembly (GO:0006336)	3.68942802
39	purine nucleobase biosynthetic process (GO:0009113)	3.59225087
40	lung-associated mesenchyme development (GO:0060484)	3.58603246
41	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.58394560
42	regulation of translation, ncRNA-mediated (GO:0045974)	3.58394560
43	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.58394560
44	nuclear pore organization (GO:0006999)	3.58391833
45	anterior/posterior axis specification, embryo (GO:0008595)	3.57282947
46	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.56794227
47	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.56794227
48	nucleobase biosynthetic process (GO:0046112)	3.55706984
49	regulation of SMAD protein import into nucleus (GO:0060390)	3.50239184
50	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.49345907
51	regulation of mitotic spindle checkpoint (GO:1903504)	3.49345907
52	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	3.47100389
53	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	3.47100389
54	negative regulation of mitotic sister chromatid segregation (GO:0033048)	3.47100389
55	negative regulation of mitotic sister chromatid separation (GO:2000816)	3.47100389
56	negative regulation of sister chromatid segregation (GO:0033046)	3.47100389
57	negative regulation of chromosome segregation (GO:0051985)	3.46635425
58	cellular protein complex localization (GO:0034629)	3.39781675
59	nodal signaling pathway (GO:0038092)	3.35602377
60	regulation of cell fate commitment (GO:0010453)	3.35444313
61	negative regulation of androgen receptor signaling pathway (GO:0060766)	3.34490076
62	ribosome assembly (GO:0042255)	3.31765504
63	negative regulation of telomerase activity (GO:0051974)	3.29942300
64	negative regulation of histone methylation (GO:0031061)	3.27226614
65	lysine metabolic process (GO:0006553)	3.24227450
66	lysine catabolic process (GO:0006554)	3.24227450
67	telomere maintenance via semi-conservative replication (GO:0032201)	3.17408431
68	ATP-dependent chromatin remodeling (GO:0043044)	3.16286454
69	mitotic spindle checkpoint (GO:0071174)	3.16009890
70	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.15306736
71	regulation of stem cell maintenance (GO:2000036)	3.15253276
72	spindle checkpoint (GO:0031577)	3.13345595
73	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.11841046
74	DNA replication initiation (GO:0006270)	3.10016707
75	metaphase plate congression (GO:0051310)	3.09346939
76	serine family amino acid biosynthetic process (GO:0009070)	3.08839181
77	regulation of chromosome segregation (GO:0051983)	3.07570518
78	single strand break repair (GO:0000012)	3.02639270
79	regulation of mitotic metaphase/anaphase transition (GO:0030071)	3.02338697
80	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	3.02338697
81	DNA damage response, detection of DNA damage (GO:0042769)	3.02196834
82	regulation of mitotic sister chromatid separation (GO:0010965)	3.01554591
83	regulation of mitotic sister chromatid segregation (GO:0033047)	3.01554591
84	regulation of sister chromatid segregation (GO:0033045)	3.01554591
85	mitotic spindle assembly checkpoint (GO:0007094)	3.00579444
86	notochord development (GO:0030903)	3.00205789
87	positive regulation of chromosome segregation (GO:0051984)	2.99713219
88	positive regulation of catenin import into nucleus (GO:0035413)	2.97392957
89	telomere maintenance via telomerase (GO:0007004)	2.97004062
90	regulation of telomere maintenance via telomerase (GO:0032210)	2.96586943
91	mitotic G2/M transition checkpoint (GO:0044818)	2.96444741
92	folic acid-containing compound biosynthetic process (GO:0009396)	2.94604871
93	regulation of DNA methylation (GO:0044030)	2.93800820
94	spindle assembly checkpoint (GO:0071173)	2.92159971
95	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.90620757
96	double-strand break repair via nonhomologous end joining (GO:0006303)	2.90245941
97	non-recombinational repair (GO:0000726)	2.90245941
98	DNA double-strand break processing (GO:0000729)	2.89426474
99	negative regulation of cell fate commitment (GO:0010454)	2.89250057
100	regulation of mesoderm development (GO:2000380)	2.87465928

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	8.51913534
2	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.98836193
3	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	3.71422424
4	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	3.71422424
5	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	3.71422424
6	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.66492800
7	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.36189068
8	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.97777724
9	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.95111408
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.95058560
11	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	2.83151609
12	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	2.80419225
13	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.77929951
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.74601328
15	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.56612274
16	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.50775905
17	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.43073211
18	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	2.41680341
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.35182027
20	NANOG_16153702_ChIP-ChIP_HESCs_Human	2.31777739
21	TCF3_18692474_ChIP-Seq_MEFs_Mouse	2.23242938
22	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.21277684
23	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.19270671
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.19017004
25	SOX2_16153702_ChIP-ChIP_HESCs_Human	2.12265473
26	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.05580023
27	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.99145690
28	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.97792097
29	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.97287679
30	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.96088145
31	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.94202203
32	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.91915285
33	AR_21909140_ChIP-Seq_LNCAP_Human	1.91225112
34	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.91013027
35	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.87932363
36	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.85866493
37	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.84266513
38	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.80741586
39	TCF3_18692474_ChIP-Seq_MESCs_Mouse	1.76527792
40	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.74835737
41	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.63097194
42	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	1.61867238
43	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.58905912
44	ELK1_19687146_ChIP-ChIP_HELA_Human	1.56756301
45	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.55383613
46	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.54107959
47	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.52369350
48	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	1.49992694
49	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.47375337
50	TTF2_22483619_ChIP-Seq_HELA_Human	1.47068939
51	FOXP3_21729870_ChIP-Seq_TREG_Human	1.44384608
52	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.38436028
53	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.38362475
54	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	1.36433512
55	XRN2_22483619_ChIP-Seq_HELA_Human	1.35872928
56	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.35825803
57	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.33562236
58	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.25826962
59	MYC_18940864_ChIP-ChIP_HL60_Human	1.25701251
60	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.25486563
61	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.22460137
62	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.20929621
63	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.20724168
64	DCP1A_22483619_ChIP-Seq_HELA_Human	1.20374142
65	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.19480540
66	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.17563837
67	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	1.17488715
68	SOX2_18692474_ChIP-Seq_MEFs_Mouse	1.16990211
69	NANOG_18347094_ChIP-ChIP_MESCs_Mouse	1.16903627
70	NANOG_21062744_ChIP-ChIP_HESCs_Human	1.16343780
71	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.16105821
72	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.13866863
73	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.12168744
74	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.11980174
75	NANOG_18692474_ChIP-Seq_MEFs_Mouse	1.08497782
76	TCF3_18347094_ChIP-ChIP_MESCs_Mouse	1.06540806
77	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.05876779
78	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.05722091
79	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.05715879
80	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.04935485
81	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.04620353
82	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.04325466
83	SOX2_18692474_ChIP-Seq_MESCs_Mouse	1.03337252
84	NANOG_18692474_ChIP-Seq_MESCs_Mouse	0.99467314
85	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.97939703
86	GABP_19822575_ChIP-Seq_HepG2_Human	0.97852392
87	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.96817878
88	VDR_23849224_ChIP-Seq_CD4+_Human	0.96550702
89	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.95718283
90	EWS_26573619_Chip-Seq_HEK293_Human	0.95582466
91	NANOG_16518401_ChIP-PET_MESCs_Mouse	0.94918436
92	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.94463914
93	IRF1_19129219_ChIP-ChIP_H3396_Human	0.94062325
94	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.92875926
95	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.92366310
96	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.91645545
97	POU5F1_18692474_ChIP-Seq_MESCs_Mouse	0.91060503
98	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.89728819
99	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.89021955
100	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.88192647

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002254_reproductive_system_inflammat	6.08504298
2	MP0003941_abnormal_skin_development	4.37697379
3	MP0003693_abnormal_embryo_hatching	4.02225023
4	MP0004957_abnormal_blastocyst_morpholog	3.91424698
5	MP0003890_abnormal_embryonic-extraembry	3.76753365
6	MP0003111_abnormal_nucleus_morphology	3.34673356
7	MP0010094_abnormal_chromosome_stability	3.28799105
8	MP0003718_maternal_effect	2.90828589
9	MP0008057_abnormal_DNA_replication	2.90210224
10	MP0008877_abnormal_DNA_methylation	2.83489818
11	MP0008058_abnormal_DNA_repair	2.76432633
12	MP0009672_abnormal_birth_weight	2.70430451
13	MP0008932_abnormal_embryonic_tissue	2.69087069
14	MP0003077_abnormal_cell_cycle	2.42056472
15	MP0006292_abnormal_olfactory_placode	2.32968026
16	MP0003136_yellow_coat_color	2.22356636
17	MP0001730_embryonic_growth_arrest	2.21432803
18	MP0003567_abnormal_fetal_cardiomyocyte	2.13484580
19	MP0003119_abnormal_digestive_system	2.08664689
20	MP0004133_heterotaxia	2.06647269
21	MP0010030_abnormal_orbit_morphology	2.03643342
22	MP0001293_anophthalmia	1.99176222
23	MP0003937_abnormal_limbs/digits/tail_de	1.90541991
24	MP0001672_abnormal_embryogenesis/_devel	1.75835502
25	MP0005380_embryogenesis_phenotype	1.75835502
26	MP0002085_abnormal_embryonic_tissue	1.75568578
27	MP0002084_abnormal_developmental_patter	1.70759734
28	MP0010352_gastrointestinal_tract_polyps	1.66332153
29	MP0000350_abnormal_cell_proliferation	1.57217599
30	MP0000537_abnormal_urethra_morphology	1.53055945
31	MP0002697_abnormal_eye_size	1.49648183
32	MP0001697_abnormal_embryo_size	1.47544970
33	MP0008007_abnormal_cellular_replicative	1.46974428
34	MP0002796_impaired_skin_barrier	1.46718984
35	MP0003984_embryonic_growth_retardation	1.46441731
36	MP0002088_abnormal_embryonic_growth/wei	1.41993508
37	MP0009703_decreased_birth_body	1.41473152
38	MP0001188_hyperpigmentation	1.39027085
39	MP0002080_prenatal_lethality	1.35211485
40	MP0000579_abnormal_nail_morphology	1.31334215
41	MP0004197_abnormal_fetal_growth/weight/	1.28562238
42	MP0002111_abnormal_tail_morphology	1.27881309
43	MP0009697_abnormal_copulation	1.21458903
44	MP0001286_abnormal_eye_development	1.20257987
45	MP0003878_abnormal_ear_physiology	1.17395741
46	MP0005377_hearing/vestibular/ear_phenot	1.17395741
47	MP0000049_abnormal_middle_ear	1.11656075
48	MP0003121_genomic_imprinting	1.11606852
49	MP0010307_abnormal_tumor_latency	1.11070704
50	MP0001849_ear_inflammation	1.09219920
51	MP0002086_abnormal_extraembryonic_tissu	1.09149745
52	MP0000428_abnormal_craniofacial_morphol	1.08603888
53	MP0004272_abnormal_basement_membrane	1.05082781
54	MP0001299_abnormal_eye_distance/	1.00248901
55	MP0003861_abnormal_nervous_system	0.99419704
56	MP0002938_white_spotting	0.95940669
57	MP0006035_abnormal_mitochondrial_morpho	0.95638373
58	MP0003787_abnormal_imprinting	0.95605619
59	MP0004264_abnormal_extraembryonic_tissu	0.94422811
60	MP0003123_paternal_imprinting	0.94093776
61	MP0000313_abnormal_cell_death	0.92836639
62	MP0002090_abnormal_vision	0.91273366
63	MP0002233_abnormal_nose_morphology	0.89238488
64	MP0001177_atelectasis	0.87855920
65	MP0000432_abnormal_head_morphology	0.87586655
66	MP0005395_other_phenotype	0.83570682
67	MP0002210_abnormal_sex_determination	0.81715842
68	MP0002736_abnormal_nociception_after	0.80695888
69	MP0005501_abnormal_skin_physiology	0.79788614
70	MP0000566_synostosis	0.78263391
71	MP0005394_taste/olfaction_phenotype	0.77369217
72	MP0005499_abnormal_olfactory_system	0.77369217
73	MP0001485_abnormal_pinna_reflex	0.76843745
74	MP0003566_abnormal_cell_adhesion	0.76182859
75	MP0001145_abnormal_male_reproductive	0.76142200
76	MP0006072_abnormal_retinal_apoptosis	0.75430997
77	MP0002751_abnormal_autonomic_nervous	0.73717666
78	MP0008770_decreased_survivor_rate	0.69178782
79	MP0001929_abnormal_gametogenesis	0.68311078
80	MP0002163_abnormal_gland_morphology	0.67863618
81	MP0004233_abnormal_muscle_weight	0.65593363
82	MP0003186_abnormal_redox_activity	0.64529425
83	MP0000653_abnormal_sex_gland	0.63535029
84	MP0000647_abnormal_sebaceous_gland	0.63005457
85	MP0003786_premature_aging	0.62862857
86	MP0003935_abnormal_craniofacial_develop	0.62846090
87	MP0001984_abnormal_olfaction	0.62012537
88	MP0000762_abnormal_tongue_morphology	0.61949744
89	MP0000490_abnormal_crypts_of	0.61877259
90	MP0004185_abnormal_adipocyte_glucose	0.61000116
91	MP0001661_extended_life_span	0.60097397
92	MP0009278_abnormal_bone_marrow	0.59583412
93	MP0001881_abnormal_mammary_gland	0.59076006
94	MP0001529_abnormal_vocalization	0.57864407
95	MP0002092_abnormal_eye_morphology	0.57855708
96	MP0000358_abnormal_cell_content/	0.57495931
97	MP0003755_abnormal_palate_morphology	0.56569840
98	MP0003699_abnormal_female_reproductive	0.55368731
99	MP0008789_abnormal_olfactory_epithelium	0.55094978
100	MP0003115_abnormal_respiratory_system	0.54883549

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	4.64341860
2	Colon cancer (HP:0003003)	4.23332869
3	Septo-optic dysplasia (HP:0100842)	4.21395020
4	Hepatoblastoma (HP:0002884)	3.55555617
5	Nephroblastoma (Wilms tumor) (HP:0002667)	3.54947913
6	Birth length less than 3rd percentile (HP:0003561)	3.42227154
7	Embryonal renal neoplasm (HP:0011794)	3.34370089
8	Spastic diplegia (HP:0001264)	3.25521526
9	Bilateral microphthalmos (HP:0007633)	3.21647851
10	Choanal stenosis (HP:0000452)	3.20116835
11	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.13775309
12	Abnormal lung lobation (HP:0002101)	3.13739531
13	Selective tooth agenesis (HP:0001592)	3.00045124
14	Multiple enchondromatosis (HP:0005701)	2.95333383
15	Ependymoma (HP:0002888)	2.93048754
16	Chromsome breakage (HP:0040012)	2.92705897
17	Meckel diverticulum (HP:0002245)	2.82537894
18	Maternal diabetes (HP:0009800)	2.78230677
19	Cortical dysplasia (HP:0002539)	2.76152043
20	Absent septum pellucidum (HP:0001331)	2.71510507
21	Hyperglycinemia (HP:0002154)	2.71257662
22	Abnormality of the septum pellucidum (HP:0007375)	2.69531502
23	Abnormality of the ileum (HP:0001549)	2.67485400
24	Hyperglycinuria (HP:0003108)	2.67371720
25	Absent radius (HP:0003974)	2.63096917
26	Stenosis of the external auditory canal (HP:0000402)	2.58286546
27	Chronic bronchitis (HP:0004469)	2.55167978
28	Abnormality of abdominal situs (HP:0011620)	2.53944932
29	Abdominal situs inversus (HP:0003363)	2.53944932
30	Abnormality of homocysteine metabolism (HP:0010919)	2.51919594
31	Homocystinuria (HP:0002156)	2.51919594
32	Aplasia involving forearm bones (HP:0009822)	2.46778155
33	Absent forearm bone (HP:0003953)	2.46778155
34	Carpal bone hypoplasia (HP:0001498)	2.43933243
35	Abnormality of serine family amino acid metabolism (HP:0010894)	2.43412194
36	Abnormality of glycine metabolism (HP:0010895)	2.43412194
37	Short hallux (HP:0010109)	2.40687280
38	Rhabdomyosarcoma (HP:0002859)	2.40406220
39	Abnormality of chromosome stability (HP:0003220)	2.32754642
40	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.32547884
41	Myelomeningocele (HP:0002475)	2.28678116
42	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.26920805
43	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.26323356
44	Abnormality of serum amino acid levels (HP:0003112)	2.24831794
45	Breast aplasia (HP:0100783)	2.22153697
46	Malignant gastrointestinal tract tumors (HP:0006749)	2.21700830
47	Gastrointestinal carcinoma (HP:0002672)	2.21700830
48	Horseshoe kidney (HP:0000085)	2.19624197
49	Neoplasm of the adrenal cortex (HP:0100641)	2.18446739
50	Medulloblastoma (HP:0002885)	2.18283612
51	Agnosia (HP:0010524)	2.16395353
52	Absent eyebrow (HP:0002223)	2.16360231
53	Bifid tongue (HP:0010297)	2.14256235
54	Aqueductal stenosis (HP:0002410)	2.13254478
55	Esophageal atresia (HP:0002032)	2.13073694
56	Biliary tract neoplasm (HP:0100574)	2.12667330
57	Hypoplasia of the pons (HP:0012110)	2.11181600
58	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.10754266
59	Hypoglycemic seizures (HP:0002173)	2.08265994
60	Increased nuchal translucency (HP:0010880)	2.07424108
61	Facial cleft (HP:0002006)	2.06724498
62	Neoplasm of the colon (HP:0100273)	2.06080702
63	Cellular immunodeficiency (HP:0005374)	2.04635691
64	Aplasia/Hypoplasia of the breasts (HP:0010311)	2.03923541
65	Abnormality of the preputium (HP:0100587)	2.03436719
66	Rectal fistula (HP:0100590)	2.02882175
67	Rectovaginal fistula (HP:0000143)	2.02882175
68	Optic nerve hypoplasia (HP:0000609)	1.99946935
69	Skull defect (HP:0001362)	1.99813740
70	Pancreatic islet-cell hyperplasia (HP:0004510)	1.99319827
71	Uterine neoplasm (HP:0010784)	1.98806169
72	Fused cervical vertebrae (HP:0002949)	1.97955965
73	Abnormality of the duodenum (HP:0002246)	1.97871970
74	Embryonal neoplasm (HP:0002898)	1.97626221
75	Supernumerary spleens (HP:0009799)	1.97398537
76	Duodenal stenosis (HP:0100867)	1.95896820
77	Small intestinal stenosis (HP:0012848)	1.95896820
78	Impulsivity (HP:0100710)	1.92856309
79	Abnormal hair whorl (HP:0010721)	1.92811682
80	Abnormality of the clitoris (HP:0000056)	1.92161093
81	Vaginal fistula (HP:0004320)	1.91546749
82	Glioma (HP:0009733)	1.91063119
83	Reticulocytopenia (HP:0001896)	1.89569931
84	Abnormality of the pons (HP:0007361)	1.89358176
85	Reduced antithrombin III activity (HP:0001976)	1.88645217
86	Ectopic kidney (HP:0000086)	1.88340109
87	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.86040219
88	Clitoromegaly (HP:0000057)	1.83858284
89	Abnormality of the lacrimal duct (HP:0011481)	1.82727703
90	Abnormality of the salivary glands (HP:0010286)	1.81117200
91	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.79942868
92	Absent eyelashes (HP:0000561)	1.79926022
93	Neoplasm of the adrenal gland (HP:0100631)	1.77989750
94	Intestinal atresia (HP:0011100)	1.77671537
95	Triphalangeal thumb (HP:0001199)	1.77221819
96	Preaxial foot polydactyly (HP:0001841)	1.76782341
97	Hypoplastic female external genitalia (HP:0012815)	1.75597919
98	Duplication of thumb phalanx (HP:0009942)	1.75036652
99	Intestinal fistula (HP:0100819)	1.75014098
100	Generalized hypotonia (HP:0001290)	1.74924901

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	3.90097942
2	TTK	3.73917266
3	BUB1	3.44128016
4	TSSK6	3.12837737
5	VRK2	3.01189187
6	ZAK	2.76987538
7	MKNK1	2.74276413
8	SRPK1	2.67810771
9	MKNK2	2.65608516
10	TAF1	2.64988410
11	PBK	2.56212677
12	TNIK	2.49565978
13	PLK3	2.44251494
14	CDK19	2.34704887
15	MAP3K10	2.06611309
16	MST4	2.05446186
17	PLK4	1.96920956
18	MAP3K9	1.73205976
19	NUAK1	1.67412136
20	ERBB4	1.66915076
21	SMG1	1.66906049
22	PLK1	1.53561987
23	NEK1	1.48208046
24	DYRK2	1.45317715
25	PASK	1.41804940
26	CHEK2	1.33757312
27	DYRK3	1.30322407
28	WEE1	1.28142569
29	STK38L	1.25858702
30	STK3	1.22890774
31	TRIM28	1.22453730
32	VRK1	1.22314203
33	ALK	1.22026198
34	FGFR1	1.21873187
35	BRSK2	1.21871011
36	NME1	1.20138641
37	LATS1	1.18903865
38	NEK2	1.16502364
39	FGFR2	1.16133947
40	WNK3	1.15491952
41	ATR	1.04751611
42	EIF2AK3	1.04233243
43	LATS2	1.04162215
44	BMX	1.02864456
45	CAMK1D	1.02333078
46	ACVR1B	0.97906884
47	STK24	0.97530415
48	PAK4	0.96990332
49	CDK12	0.96218775
50	BRD4	0.95232720
51	EEF2K	0.90677066
52	CAMK1G	0.90379110
53	CSNK1G1	0.86074196
54	CHEK1	0.85316790
55	EIF2AK2	0.85139723
56	ATM	0.84871607
57	OXSR1	0.84040537
58	KDR	0.80523943
59	CDK7	0.78798287
60	NLK	0.76857594
61	AURKB	0.74175016
62	STK4	0.73324844
63	BMPR1B	0.72886544
64	STK16	0.70393575
65	FLT3	0.67115177
66	MAP3K8	0.66578613
67	PNCK	0.65345612
68	DAPK1	0.61829326
69	PIM1	0.60521692
70	CDK1	0.58262547
71	BRSK1	0.57816551
72	BRAF	0.57809307
73	TIE1	0.56410097
74	CASK	0.55974639
75	CDK2	0.55590985
76	CSNK1E	0.54086140
77	AURKA	0.53857001
78	DMPK	0.51420972
79	PRKDC	0.51262839
80	NME2	0.50896878
81	CSNK1G2	0.50678670
82	BCR	0.47396487
83	EIF2AK1	0.47177053
84	TGFBR1	0.46793784
85	CDK4	0.45796992
86	EGFR	0.44333227
87	RPS6KA4	0.43057606
88	CSNK2A1	0.42645132
89	CSNK1G3	0.42306867
90	PLK2	0.38713854
91	RPS6KB2	0.38186391
92	FGFR4	0.35884013
93	CSNK2A2	0.35728714
94	MET	0.32436442
95	PAK1	0.32145902
96	PRKG2	0.30025693
97	GSK3B	0.27259781
98	GRK1	0.26933835
99	CSNK1A1L	0.26686973
100	CDK6	0.23678162

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	3.92161582
2	Mismatch repair_Homo sapiens_hsa03430	3.78818949
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.14051254
4	Non-homologous end-joining_Homo sapiens_hsa03450	2.86266551
5	Proteasome_Homo sapiens_hsa03050	2.75397854
6	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.71196271
7	RNA transport_Homo sapiens_hsa03013	2.65109113
8	Spliceosome_Homo sapiens_hsa03040	2.55146400
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.52265933
10	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.51952555
11	Base excision repair_Homo sapiens_hsa03410	2.47450963
12	One carbon pool by folate_Homo sapiens_hsa00670	2.37572032
13	Cell cycle_Homo sapiens_hsa04110	2.35179529
14	Homologous recombination_Homo sapiens_hsa03440	2.35069257
15	RNA polymerase_Homo sapiens_hsa03020	2.24982609
16	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.15342326
17	mRNA surveillance pathway_Homo sapiens_hsa03015	1.96900419
18	Basal transcription factors_Homo sapiens_hsa03022	1.95725639
19	RNA degradation_Homo sapiens_hsa03018	1.79129358
20	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.77088693
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.66535564
22	Nucleotide excision repair_Homo sapiens_hsa03420	1.65950137
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.62627136
24	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.57090024
25	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.51488175
26	Steroid biosynthesis_Homo sapiens_hsa00100	1.51028190
27	Pyruvate metabolism_Homo sapiens_hsa00620	1.50604804
28	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.48540059
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.45066120
30	Ribosome_Homo sapiens_hsa03010	1.44694253
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.24942764
32	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.19861970
33	Propanoate metabolism_Homo sapiens_hsa00640	1.19212024
34	Carbon metabolism_Homo sapiens_hsa01200	1.17602611
35	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.12245116
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.11037414
37	Purine metabolism_Homo sapiens_hsa00230	1.10237307
38	Adherens junction_Homo sapiens_hsa04520	1.08805203
39	Basal cell carcinoma_Homo sapiens_hsa05217	1.05532468
40	Tight junction_Homo sapiens_hsa04530	1.00472626
41	Oocyte meiosis_Homo sapiens_hsa04114	0.99187762
42	Wnt signaling pathway_Homo sapiens_hsa04310	0.98001268
43	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.96608134
44	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.96007625
45	Hippo signaling pathway_Homo sapiens_hsa04390	0.95311117
46	Thyroid cancer_Homo sapiens_hsa05216	0.94697386
47	Protein export_Homo sapiens_hsa03060	0.93597679
48	p53 signaling pathway_Homo sapiens_hsa04115	0.92904622
49	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.89442078
50	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.87253590
51	Lysine degradation_Homo sapiens_hsa00310	0.86828105
52	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.82286015
53	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.81482805
54	Folate biosynthesis_Homo sapiens_hsa00790	0.79974464
55	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.77553418
56	Fatty acid elongation_Homo sapiens_hsa00062	0.77460964
57	Glutathione metabolism_Homo sapiens_hsa00480	0.74964422
58	Huntingtons disease_Homo sapiens_hsa05016	0.70898165
59	Arginine and proline metabolism_Homo sapiens_hsa00330	0.70702126
60	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.66140526
61	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.62259432
62	MicroRNAs in cancer_Homo sapiens_hsa05206	0.60358904
63	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.59457529
64	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.59452947
65	Parkinsons disease_Homo sapiens_hsa05012	0.56640804
66	Pentose phosphate pathway_Homo sapiens_hsa00030	0.55157248
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.54126998
68	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.52736947
69	Galactose metabolism_Homo sapiens_hsa00052	0.51927239
70	Metabolic pathways_Homo sapiens_hsa01100	0.51868677
71	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.50877129
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.47049311
73	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.46512824
74	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.44246154
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37947564
76	Fatty acid metabolism_Homo sapiens_hsa01212	0.37381650
77	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.36800484
78	Phototransduction_Homo sapiens_hsa04744	0.35406252
79	Retinol metabolism_Homo sapiens_hsa00830	0.33654342
80	Colorectal cancer_Homo sapiens_hsa05210	0.33240140
81	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.29848500
82	Oxidative phosphorylation_Homo sapiens_hsa00190	0.28704746
83	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.27350856
84	Arginine biosynthesis_Homo sapiens_hsa00220	0.26905475
85	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.25855262
86	Nicotine addiction_Homo sapiens_hsa05033	0.25615735
87	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.24828048
88	Taste transduction_Homo sapiens_hsa04742	0.24434107
89	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.24411540
90	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.23040199
91	Sulfur relay system_Homo sapiens_hsa04122	0.22337182
92	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.18525634
93	Prostate cancer_Homo sapiens_hsa05215	0.18106493
94	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.17982465
95	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.17713432
96	Ether lipid metabolism_Homo sapiens_hsa00565	0.17263011
97	Fatty acid degradation_Homo sapiens_hsa00071	0.17036657
98	Fat digestion and absorption_Homo sapiens_hsa04975	0.16927696
99	Melanoma_Homo sapiens_hsa05218	0.16183108
100	Tryptophan metabolism_Homo sapiens_hsa00380	0.14756820

LINC00371

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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