ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	4.66003688
2	DNA methylation involved in gamete generation (GO:0043046)	4.21590835
3	resolution of meiotic recombination intermediates (GO:0000712)	4.19496003
4	proteasome assembly (GO:0043248)	4.13103682
5	ribosome assembly (GO:0042255)	3.84757084
6	centriole replication (GO:0007099)	3.80603896
7	protein K11-linked deubiquitination (GO:0035871)	3.76790570
8	replication fork processing (GO:0031297)	3.74998888
9	pseudouridine synthesis (GO:0001522)	3.64360438
10	male meiosis (GO:0007140)	3.58345024
11	mitotic sister chromatid segregation (GO:0000070)	3.47338191
12	regulation of mitotic spindle organization (GO:0060236)	3.44645965
13	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.43635425
14	double-strand break repair via homologous recombination (GO:0000724)	3.41308360
15	meiotic chromosome segregation (GO:0045132)	3.39485795
16	regulation of histone H3-K4 methylation (GO:0051569)	3.39074771
17	nuclear pore organization (GO:0006999)	3.34945833
18	sister chromatid segregation (GO:0000819)	3.34480035
19	recombinational repair (GO:0000725)	3.33706796
20	mitotic nuclear envelope disassembly (GO:0007077)	3.33651645
21	piRNA metabolic process (GO:0034587)	3.31920651
22	nuclear pore complex assembly (GO:0051292)	3.30397448
23	DNA double-strand break processing (GO:0000729)	3.30027737
24	purine nucleobase biosynthetic process (GO:0009113)	3.29778641
25	positive regulation of histone H3-K4 methylation (GO:0051571)	3.27736144
26	DNA topological change (GO:0006265)	3.25674078
27	DNA replication checkpoint (GO:0000076)	3.23082585
28	mitotic metaphase plate congression (GO:0007080)	3.22626293
29	rRNA catabolic process (GO:0016075)	3.18833077
30	DNA deamination (GO:0045006)	3.18762571
31	terpenoid biosynthetic process (GO:0016114)	3.17871277
32	centriole assembly (GO:0098534)	3.17671905
33	reciprocal meiotic recombination (GO:0007131)	3.12733972
34	reciprocal DNA recombination (GO:0035825)	3.12733972
35	rRNA modification (GO:0000154)	3.11645733
36	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.10816921
37	cell wall macromolecule catabolic process (GO:0016998)	3.10261032
38	telomere maintenance via semi-conservative replication (GO:0032201)	3.10134276
39	nucleobase biosynthetic process (GO:0046112)	3.04301440
40	regulation of translational fidelity (GO:0006450)	3.03929845
41	pore complex assembly (GO:0046931)	3.02206160
42	mitochondrial RNA metabolic process (GO:0000959)	3.01256284
43	mannosylation (GO:0097502)	2.99492384
44	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.98654719
45	sensory perception of smell (GO:0007608)	2.98159607
46	rRNA methylation (GO:0031167)	2.98152315
47	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.97013967
48	membrane disassembly (GO:0030397)	2.94964148
49	nuclear envelope disassembly (GO:0051081)	2.94964148
50	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.94790262
51	chromosome organization involved in meiosis (GO:0070192)	2.93789350
52	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.92705928
53	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.92487730
54	cell wall macromolecule metabolic process (GO:0044036)	2.92254531
55	mismatch repair (GO:0006298)	2.91845447
56	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.91436825
57	positive regulation of ligase activity (GO:0051351)	2.90418798
58	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.87146867
59	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.87146867
60	mitotic recombination (GO:0006312)	2.86109118
61	DNA strand elongation involved in DNA replication (GO:0006271)	2.85367812
62	DNA catabolic process, exonucleolytic (GO:0000738)	2.84975749
63	telomere maintenance via recombination (GO:0000722)	2.84886619
64	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.82137837
65	aggressive behavior (GO:0002118)	2.77565585
66	protein K6-linked ubiquitination (GO:0085020)	2.77010477
67	poly(A)+ mRNA export from nucleus (GO:0016973)	2.75668424
68	interkinetic nuclear migration (GO:0022027)	2.75052518
69	ribonucleoprotein complex disassembly (GO:0032988)	2.74705065
70	diterpenoid biosynthetic process (GO:0016102)	2.74430213
71	negative regulation of ligase activity (GO:0051352)	2.73156150
72	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.73156150
73	positive regulation of histone methylation (GO:0031062)	2.70377546
74	regulation of cellular amino acid metabolic process (GO:0006521)	2.70204651
75	organelle membrane fusion (GO:0090174)	2.70025003
76	metaphase plate congression (GO:0051310)	2.68831816
77	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.67691150
78	maturation of 5.8S rRNA (GO:0000460)	2.65431649
79	DNA strand elongation (GO:0022616)	2.64129994
80	double-strand break repair (GO:0006302)	2.62389554
81	regulation of spindle organization (GO:0090224)	2.61418214
82	transcription from mitochondrial promoter (GO:0006390)	2.61386751
83	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.61337639
84	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.61337639
85	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.61337639
86	tachykinin receptor signaling pathway (GO:0007217)	2.61188182
87	chromosome segregation (GO:0007059)	2.60874183
88	attachment of spindle microtubules to kinetochore (GO:0008608)	2.60466280
89	tRNA aminoacylation for protein translation (GO:0006418)	2.59669039
90	DNA replication initiation (GO:0006270)	2.59184564
91	regulation of mitochondrial translation (GO:0070129)	2.59039836
92	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.58599855
93	definitive hemopoiesis (GO:0060216)	2.58526540
94	meiotic nuclear division (GO:0007126)	2.56183043
95	mitotic chromosome condensation (GO:0007076)	2.56094930
96	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.56031592
97	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.56031592
98	amino acid activation (GO:0043038)	2.54989170
99	tRNA aminoacylation (GO:0043039)	2.54989170
100	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.54696792

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.57213557
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.48419772
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.43417310
4	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.39017477
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.30526224
6	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.23284848
7	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.09577440
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.01174245
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.81317926
10	ELK1_19687146_ChIP-ChIP_HELA_Human	2.71990811
11	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.68415612
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.66064074
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.64251446
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.58219390
15	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.44042351
16	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.35566341
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.31421148
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.20758559
19	DCP1A_22483619_ChIP-Seq_HELA_Human	2.19997971
20	VDR_22108803_ChIP-Seq_LS180_Human	2.04150178
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.03356435
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.01270091
23	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.94114169
24	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.94068280
25	ZNF274_21170338_ChIP-Seq_K562_Hela	1.93630613
26	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.93586658
27	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.88309097
28	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.82731289
29	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.81623589
30	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.81136402
31	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.76499112
32	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.75251102
33	GATA1_22025678_ChIP-Seq_K562_Human	1.65635549
34	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.65286013
35	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.64000832
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.62503203
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.61368567
38	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.60143287
39	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.54512359
40	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.49571655
41	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.48696367
42	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.48042821
43	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.47858254
44	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.44478730
45	ZNF263_19887448_ChIP-Seq_K562_Human	1.43798574
46	AR_21909140_ChIP-Seq_LNCAP_Human	1.41173444
47	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.40325080
48	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.39768901
49	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.38628385
50	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.38276001
51	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.38031180
52	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.37208340
53	SCL_19346495_ChIP-Seq_HPC-7_Human	1.35085098
54	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.34971380
55	XRN2_22483619_ChIP-Seq_HELA_Human	1.30749073
56	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.28742964
57	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.28445523
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.23367466
59	TTF2_22483619_ChIP-Seq_HELA_Human	1.21595355
60	KDM5A_27292631_Chip-Seq_BREAST_Human	1.21144238
61	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.21091242
62	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.19250081
63	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.19139590
64	ER_23166858_ChIP-Seq_MCF-7_Human	1.12904948
65	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.12054819
66	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.11753693
67	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.10324119
68	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.06217070
69	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.05667819
70	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.05229227
71	GATA3_26560356_Chip-Seq_TH2_Human	1.03908787
72	IGF1R_20145208_ChIP-Seq_DFB_Human	1.03620003
73	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.02232830
74	TP53_22573176_ChIP-Seq_HFKS_Human	1.01964986
75	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.01353705
76	NCOR1_26117541_ChIP-Seq_K562_Human	1.00271595
77	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.99971389
78	GATA2_19941826_ChIP-Seq_K562_Human	0.98996008
79	FUS_26573619_Chip-Seq_HEK293_Human	0.98368891
80	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.97431102
81	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.96805532
82	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.96230572
83	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.96152016
84	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.96152016
85	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.95357683
86	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94389546
87	EWS_26573619_Chip-Seq_HEK293_Human	0.91670452
88	GATA1_19941826_ChIP-Seq_K562_Human	0.91256225
89	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.90222291
90	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.90069783
91	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.89733830
92	AR_20517297_ChIP-Seq_VCAP_Human	0.89078175
93	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.88472033
94	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.87861104
95	SPI1_23127762_ChIP-Seq_K562_Human	0.87022627
96	ERG_20517297_ChIP-Seq_VCAP_Human	0.82331965
97	GATA3_26560356_Chip-Seq_TH1_Human	0.80586879
98	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.79431900
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.79316322
100	MYB_26560356_Chip-Seq_TH2_Human	0.78804567

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008995_early_reproductive_senescence	5.16331285
2	MP0003806_abnormal_nucleotide_metabolis	4.61447430
3	MP0003786_premature_aging	3.48591991
4	MP0010094_abnormal_chromosome_stability	3.39826800
5	MP0009697_abnormal_copulation	3.37251378
6	MP0003950_abnormal_plasma_membrane	3.27393666
7	MP0000569_abnormal_digit_pigmentation	3.13458863
8	MP0008058_abnormal_DNA_repair	2.88947670
9	MP0004147_increased_porphyrin_level	2.77483335
10	MP0003718_maternal_effect	2.47651849
11	MP0003111_abnormal_nucleus_morphology	2.46111683
12	MP0004957_abnormal_blastocyst_morpholog	2.30425537
13	MP0003693_abnormal_embryo_hatching	2.29778194
14	MP0002132_abnormal_respiratory_system	2.19748640
15	MP0005360_urolithiasis	2.16953278
16	MP0002837_dystrophic_cardiac_calcinosis	2.15849009
17	MP0003646_muscle_fatigue	2.12966560
18	MP0008057_abnormal_DNA_replication	2.10580725
19	MP0008877_abnormal_DNA_methylation	2.06847544
20	MP0003656_abnormal_erythrocyte_physiolo	1.95444057
21	MP0003077_abnormal_cell_cycle	1.94151078
22	MP0006036_abnormal_mitochondrial_physio	1.86183380
23	MP0003195_calcinosis	1.74571844
24	MP0001929_abnormal_gametogenesis	1.69978502
25	MP0000372_irregular_coat_pigmentation	1.62761255
26	MP0001853_heart_inflammation	1.60632914
27	MP0003136_yellow_coat_color	1.59636136
28	MP0001764_abnormal_homeostasis	1.54116589
29	MP0002396_abnormal_hematopoietic_system	1.53020252
30	MP0005083_abnormal_biliary_tract	1.52078622
31	MP0006035_abnormal_mitochondrial_morpho	1.47091164
32	MP0005266_abnormal_metabolism	1.45066661
33	MP0008007_abnormal_cellular_replicative	1.44284761
34	MP0003186_abnormal_redox_activity	1.39797040
35	MP0005410_abnormal_fertilization	1.36047942
36	MP0002210_abnormal_sex_determination	1.33164920
37	MP0008932_abnormal_embryonic_tissue	1.30182291
38	MP0005397_hematopoietic_system_phenotyp	1.28799339
39	MP0001545_abnormal_hematopoietic_system	1.28799339
40	MP0005174_abnormal_tail_pigmentation	1.22377885
41	MP0002102_abnormal_ear_morphology	1.18835291
42	MP0002938_white_spotting	1.17968706
43	MP0005376_homeostasis/metabolism_phenot	1.14888953
44	MP0000678_abnormal_parathyroid_gland	1.13841215
45	MP0000653_abnormal_sex_gland	1.12691005
46	MP0005451_abnormal_body_composition	1.10386526
47	MP0001145_abnormal_male_reproductive	1.09646900
48	MP0002269_muscular_atrophy	1.09013275
49	MP0008875_abnormal_xenobiotic_pharmacok	1.08556101
50	MP0005636_abnormal_mineral_homeostasis	1.07919407
51	MP0003698_abnormal_male_reproductive	1.07348583
52	MP0005332_abnormal_amino_acid	1.05154723
53	MP0000358_abnormal_cell_content/	1.04995457
54	MP0003943_abnormal_hepatobiliary_system	1.04830369
55	MP0005551_abnormal_eye_electrophysiolog	1.00450566
56	MP0000681_abnormal_thyroid_gland	0.99623980
57	MP0005646_abnormal_pituitary_gland	0.98153988
58	MP0002148_abnormal_hypersensitivity_rea	0.98139694
59	MP0005075_abnormal_melanosome_morpholog	0.91484148
60	MP0002160_abnormal_reproductive_system	0.90092631
61	MP0002095_abnormal_skin_pigmentation	0.88827305
62	MP0004808_abnormal_hematopoietic_stem	0.88120507
63	MP0002019_abnormal_tumor_incidence	0.88076508
64	MP0005395_other_phenotype	0.87262685
65	MP0001501_abnormal_sleep_pattern	0.84890669
66	MP0001697_abnormal_embryo_size	0.84320063
67	MP0001984_abnormal_olfaction	0.83513432
68	MP0002398_abnormal_bone_marrow	0.82375914
69	MP0002722_abnormal_immune_system	0.81495124
70	MP0004019_abnormal_vitamin_homeostasis	0.78723904
71	MP0001529_abnormal_vocalization	0.77572489
72	MP0000313_abnormal_cell_death	0.77007296
73	MP0001666_abnormal_nutrient_absorption	0.76652965
74	MP0009840_abnormal_foam_cell	0.76557000
75	MP0000749_muscle_degeneration	0.75601649
76	MP0002234_abnormal_pharynx_morphology	0.75460156
77	MP0000689_abnormal_spleen_morphology	0.75421134
78	MP0008775_abnormal_heart_ventricle	0.73745013
79	MP0002332_abnormal_exercise_endurance	0.73164981
80	MP0005253_abnormal_eye_physiology	0.73004281
81	MP0001502_abnormal_circadian_rhythm	0.72652696
82	MP0006072_abnormal_retinal_apoptosis	0.72598361
83	MP0005389_reproductive_system_phenotype	0.71337592
84	MP0002928_abnormal_bile_duct	0.71128442
85	MP0000703_abnormal_thymus_morphology	0.69119902
86	MP0004264_abnormal_extraembryonic_tissu	0.68366176
87	MP0003252_abnormal_bile_duct	0.67340420
88	MP0005164_abnormal_response_to	0.66838890
89	MP0003045_fibrosis	0.66669813
90	MP0001119_abnormal_female_reproductive	0.66238899
91	MP0009333_abnormal_splenocyte_physiolog	0.63523589
92	MP0008872_abnormal_physiological_respon	0.61277612
93	MP0004145_abnormal_muscle_electrophysio	0.60678670
94	MP0002876_abnormal_thyroid_physiology	0.59077417
95	MP0009785_altered_susceptibility_to	0.58951318
96	MP0003699_abnormal_female_reproductive	0.58913606
97	MP0002080_prenatal_lethality	0.58605291
98	MP0000015_abnormal_ear_pigmentation	0.58523807
99	MP0002086_abnormal_extraembryonic_tissu	0.58182774
100	MP0002429_abnormal_blood_cell	0.57750227

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.29155375
2	Chromsome breakage (HP:0040012)	4.19554195
3	Pancreatic cysts (HP:0001737)	3.60827616
4	True hermaphroditism (HP:0010459)	3.47844274
5	Type II lissencephaly (HP:0007260)	3.45471238
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.42135958
7	Acute necrotizing encephalopathy (HP:0006965)	3.37662766
8	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.35645179
9	Pancreatic fibrosis (HP:0100732)	3.32891730
10	Lipid accumulation in hepatocytes (HP:0006561)	3.29066441
11	Decreased central vision (HP:0007663)	3.21953199
12	Duplicated collecting system (HP:0000081)	3.21642650
13	Truncus arteriosus (HP:0001660)	3.14610042
14	Cerebellar dysplasia (HP:0007033)	3.12343325
15	Abnormality of the preputium (HP:0100587)	3.09975912
16	Abnormality of the renal collecting system (HP:0004742)	3.08367375
17	Acute encephalopathy (HP:0006846)	3.03801481
18	Type I transferrin isoform profile (HP:0003642)	3.03552109
19	Meckel diverticulum (HP:0002245)	2.98392353
20	Increased CSF lactate (HP:0002490)	2.97229492
21	Hypertensive crisis (HP:0100735)	2.96152626
22	Hypoplasia of the pons (HP:0012110)	2.93919144
23	Progressive macrocephaly (HP:0004481)	2.91575936
24	Abnormality of the pons (HP:0007361)	2.90264586
25	Abnormality of chromosome stability (HP:0003220)	2.87252977
26	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.85724436
27	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.85724436
28	Hyperthyroidism (HP:0000836)	2.84471205
29	Abnormality of the ileum (HP:0001549)	2.80977981
30	Increased hepatocellular lipid droplets (HP:0006565)	2.77325932
31	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.74696222
32	Mitochondrial inheritance (HP:0001427)	2.65351941
33	Birth length less than 3rd percentile (HP:0003561)	2.64157035
34	Clubbing of toes (HP:0100760)	2.61798994
35	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.60041296
36	Abnormal protein N-linked glycosylation (HP:0012347)	2.60041296
37	Abnormal protein glycosylation (HP:0012346)	2.60041296
38	Abnormal glycosylation (HP:0012345)	2.60041296
39	Abnormality of DNA repair (HP:0003254)	2.58453225
40	Myelodysplasia (HP:0002863)	2.55526506
41	Duodenal stenosis (HP:0100867)	2.55470558
42	Small intestinal stenosis (HP:0012848)	2.55470558
43	Absent thumb (HP:0009777)	2.55105116
44	Autoimmune hemolytic anemia (HP:0001890)	2.45829282
45	Sloping forehead (HP:0000340)	2.45391105
46	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.45244109
47	Attenuation of retinal blood vessels (HP:0007843)	2.43841848
48	Increased intramyocellular lipid droplets (HP:0012240)	2.39945571
49	Increased muscle lipid content (HP:0009058)	2.37910171
50	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.36067921
51	Abnormality of alanine metabolism (HP:0010916)	2.36067921
52	Hyperalaninemia (HP:0003348)	2.36067921
53	Increased serum pyruvate (HP:0003542)	2.34367605
54	Cholecystitis (HP:0001082)	2.32814074
55	Abnormal gallbladder physiology (HP:0012438)	2.32814074
56	Reduced antithrombin III activity (HP:0001976)	2.31504494
57	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.29785358
58	Cerebral edema (HP:0002181)	2.27608899
59	Increased corneal curvature (HP:0100692)	2.25472652
60	Keratoconus (HP:0000563)	2.25472652
61	Hepatocellular necrosis (HP:0001404)	2.23025664
62	Respiratory difficulties (HP:0002880)	2.21793964
63	Increased serum lactate (HP:0002151)	2.20911341
64	Abnormality of glycolysis (HP:0004366)	2.17329900
65	Retinal dysplasia (HP:0007973)	2.13321313
66	Abnormality of midbrain morphology (HP:0002418)	2.12692898
67	Molar tooth sign on MRI (HP:0002419)	2.12692898
68	Ileus (HP:0002595)	2.10196018
69	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.07088801
70	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.06377034
71	Furrowed tongue (HP:0000221)	2.06195801
72	Seborrheic dermatitis (HP:0001051)	2.05529592
73	Hepatic necrosis (HP:0002605)	2.02833977
74	Renal Fanconi syndrome (HP:0001994)	2.02421337
75	Abnormality of serum amino acid levels (HP:0003112)	2.02340120
76	Abnormality of the duodenum (HP:0002246)	1.99142699
77	Abnormal rod and cone electroretinograms (HP:0008323)	1.95904469
78	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.94901418
79	Microvesicular hepatic steatosis (HP:0001414)	1.89598362
80	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.89103543
81	Cystic liver disease (HP:0006706)	1.88409147
82	Sclerocornea (HP:0000647)	1.86765298
83	Optic disc pallor (HP:0000543)	1.85997513
84	Lactic acidosis (HP:0003128)	1.85585744
85	Overlapping toe (HP:0001845)	1.85445349
86	Nephronophthisis (HP:0000090)	1.83462807
87	Methylmalonic aciduria (HP:0012120)	1.81805617
88	Abnormality of T cell physiology (HP:0011840)	1.81401176
89	Acute hepatic failure (HP:0006554)	1.81272630
90	Exercise intolerance (HP:0003546)	1.80410865
91	Abnormality of cochlea (HP:0000375)	1.79668693
92	Short tibia (HP:0005736)	1.78825114
93	Abnormality of pyrimidine metabolism (HP:0004353)	1.77838730
94	Methylmalonic acidemia (HP:0002912)	1.75248138
95	Congenital stationary night blindness (HP:0007642)	1.75039592
96	Bone marrow hypocellularity (HP:0005528)	1.73573817
97	Bile duct proliferation (HP:0001408)	1.73149495
98	Abnormal biliary tract physiology (HP:0012439)	1.73149495
99	Aplastic anemia (HP:0001915)	1.72953281
100	Abnormality of the carotid arteries (HP:0005344)	1.70283711

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	5.71900266
2	MST1R	4.32966930
3	EIF2AK3	3.59668514
4	EIF2AK1	3.08282363
5	PINK1	2.85711089
6	MAP4K2	2.84010899
7	MST4	2.65305091
8	NME1	2.48307529
9	ZAK	2.46697675
10	FRK	2.44753481
11	PDK2	2.28284448
12	NME2	2.11701237
13	BRSK2	2.02869208
14	BMPR2	2.00152587
15	TTK	1.94327294
16	TRIM28	1.89497056
17	LATS1	1.85594028
18	PBK	1.84611707
19	CCNB1	1.82000613
20	TRPM7	1.64552359
21	BUB1	1.63012491
22	NEK1	1.59223190
23	SRPK1	1.49596884
24	MAP3K13	1.44010858
25	WEE1	1.37460304
26	CDC7	1.28898377
27	PLK4	1.28731531
28	BMPR1B	1.27611485
29	RIPK4	1.26746395
30	NEK2	1.21905095
31	CLK1	1.18334980
32	CHEK2	1.14147225
33	MET	1.14091069
34	ADRBK2	1.10222244
35	CDK8	1.08708596
36	MARK3	1.03703872
37	MAPKAPK3	0.99992964
38	ATR	0.98708732
39	EIF2AK2	0.98235149
40	TSSK6	0.96656747
41	NUAK1	0.96091874
42	PLK3	0.95364277
43	PLK1	0.95085902
44	VRK2	0.94077298
45	IRAK3	0.92495811
46	OBSCN	0.91731325
47	MAP3K2	0.88219530
48	GRK1	0.82430659
49	TEC	0.80215378
50	ATM	0.79685780
51	STK3	0.74902148
52	STK38L	0.72112276
53	MAP2K2	0.71946972
54	RAF1	0.68167794
55	KDR	0.65908042
56	VRK1	0.64587826
57	ERBB3	0.64455005
58	CDK3	0.63700962
59	IKBKB	0.60556302
60	BRSK1	0.60061107
61	MAP3K7	0.60025093
62	GRK5	0.59586955
63	AURKB	0.57421082
64	KSR2	0.56280660
65	MAP3K1	0.56172919
66	DAPK1	0.53836918
67	BMX	0.50118385
68	SCYL2	0.49762446
69	MAP2K1	0.49370071
70	RPS6KA5	0.47085101
71	CSNK2A2	0.46357810
72	TLK1	0.46350020
73	MKNK2	0.45075733
74	INSRR	0.43357978
75	PIM1	0.41720751
76	CSNK2A1	0.41356447
77	KSR1	0.40282007
78	PIK3CG	0.40175503
79	MELK	0.39061401
80	RPS6KA4	0.38730308
81	MAP3K9	0.37482393
82	MAP3K14	0.36832395
83	CHEK1	0.36799112
84	RPS6KB2	0.35327387
85	ARAF	0.34046941
86	ITK	0.32516367
87	AURKA	0.31322055
88	MAPK11	0.30913813
89	PAK1	0.30837001
90	EPHA2	0.30801156
91	PTK2B	0.30634069
92	JAK2	0.30454688
93	CDK1	0.29591479
94	STK4	0.27853335
95	GRK7	0.27213429
96	WNK3	0.25901480
97	PHKG1	0.25424828
98	PHKG2	0.25424828
99	STK16	0.25223406
100	MKNK1	0.24491547

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	4.13856493
2	Proteasome_Homo sapiens_hsa03050	3.86792552
3	One carbon pool by folate_Homo sapiens_hsa00670	3.64280421
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.33597366
5	DNA replication_Homo sapiens_hsa03030	3.13787777
6	Fanconi anemia pathway_Homo sapiens_hsa03460	3.11433351
7	Mismatch repair_Homo sapiens_hsa03430	2.56960994
8	Phototransduction_Homo sapiens_hsa04744	2.56699267
9	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.39625527
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.12313707
11	RNA transport_Homo sapiens_hsa03013	2.12298124
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.05985150
13	Parkinsons disease_Homo sapiens_hsa05012	2.05517195
14	Basal transcription factors_Homo sapiens_hsa03022	2.00485648
15	Olfactory transduction_Homo sapiens_hsa04740	1.99492497
16	Nucleotide excision repair_Homo sapiens_hsa03420	1.97673503
17	RNA polymerase_Homo sapiens_hsa03020	1.93610483
18	RNA degradation_Homo sapiens_hsa03018	1.93492349
19	Spliceosome_Homo sapiens_hsa03040	1.87905634
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.72519009
21	Pyrimidine metabolism_Homo sapiens_hsa00240	1.63355648
22	Butanoate metabolism_Homo sapiens_hsa00650	1.60796037
23	Ribosome_Homo sapiens_hsa03010	1.55876637
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.54973486
25	Purine metabolism_Homo sapiens_hsa00230	1.53336953
26	Cell cycle_Homo sapiens_hsa04110	1.52496171
27	Huntingtons disease_Homo sapiens_hsa05016	1.50585816
28	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.48346924
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.37345468
30	Base excision repair_Homo sapiens_hsa03410	1.36238510
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.31389463
32	Non-homologous end-joining_Homo sapiens_hsa03450	1.28147000
33	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.28116628
34	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.26863140
35	Propanoate metabolism_Homo sapiens_hsa00640	1.25056434
36	mRNA surveillance pathway_Homo sapiens_hsa03015	1.16759892
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.15772314
38	Alzheimers disease_Homo sapiens_hsa05010	1.09931952
39	Protein export_Homo sapiens_hsa03060	1.06622443
40	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.01505394
41	Selenocompound metabolism_Homo sapiens_hsa00450	0.99909923
42	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.99358991
43	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.98248025
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.97833530
45	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.94029008
46	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.89962890
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88946170
48	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.87365066
49	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.86874777
50	Pyruvate metabolism_Homo sapiens_hsa00620	0.85363758
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.84958098
52	Glutathione metabolism_Homo sapiens_hsa00480	0.84165603
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.83319731
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82411083
55	Retinol metabolism_Homo sapiens_hsa00830	0.81255629
56	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.77380597
57	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.75448806
58	Oocyte meiosis_Homo sapiens_hsa04114	0.74153122
59	Metabolic pathways_Homo sapiens_hsa01100	0.72846736
60	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.67874306
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66779613
62	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.61222985
63	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.55306614
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.53455532
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52768238
66	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.52591619
67	Taste transduction_Homo sapiens_hsa04742	0.51678800
68	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.50653893
69	Steroid biosynthesis_Homo sapiens_hsa00100	0.50281908
70	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.50170153
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.48738070
72	Sulfur relay system_Homo sapiens_hsa04122	0.47954853
73	Tyrosine metabolism_Homo sapiens_hsa00350	0.46852630
74	Linoleic acid metabolism_Homo sapiens_hsa00591	0.45261391
75	Sulfur metabolism_Homo sapiens_hsa00920	0.45216779
76	Tryptophan metabolism_Homo sapiens_hsa00380	0.45116854
77	Circadian rhythm_Homo sapiens_hsa04710	0.42612145
78	Sphingolipid metabolism_Homo sapiens_hsa00600	0.42438219
79	Legionellosis_Homo sapiens_hsa05134	0.41877216
80	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.40341950
81	Caffeine metabolism_Homo sapiens_hsa00232	0.39964656
82	Carbon metabolism_Homo sapiens_hsa01200	0.39635883
83	Herpes simplex infection_Homo sapiens_hsa05168	0.39433842
84	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.38588598
85	p53 signaling pathway_Homo sapiens_hsa04115	0.36632782
86	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.35777909
87	Regulation of autophagy_Homo sapiens_hsa04140	0.33347923
88	Peroxisome_Homo sapiens_hsa04146	0.33255452
89	ABC transporters_Homo sapiens_hsa02010	0.32493499
90	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.31616269
91	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.30775406
92	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.29071474
93	Other glycan degradation_Homo sapiens_hsa00511	0.28348177
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.26567883
95	Mineral absorption_Homo sapiens_hsa04978	0.23976398
96	Apoptosis_Homo sapiens_hsa04210	0.21937571
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.19311208
98	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.19297844
99	Fatty acid elongation_Homo sapiens_hsa00062	0.17411947
100	Measles_Homo sapiens_hsa05162	0.17359349

LINC00431

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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