ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	9.21552401
2	spermatid development (GO:0007286)	7.77070088
3	multicellular organism reproduction (GO:0032504)	7.29426386
4	regulation of phosphoprotein phosphatase activity (GO:0043666)	6.94656329
5	fusion of sperm to egg plasma membrane (GO:0007342)	6.65022810
6	positive regulation of catecholamine secretion (GO:0033605)	6.43753335
7	sperm-egg recognition (GO:0035036)	6.11150599
8	binding of sperm to zona pellucida (GO:0007339)	6.09948099
9	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	6.04689600
10	male meiosis (GO:0007140)	6.04159106
11	motile cilium assembly (GO:0044458)	5.95718846
12	regulation of oxidative stress-induced neuron death (GO:1903203)	5.95241100
13	reproduction (GO:0000003)	5.68827453
14	axonemal dynein complex assembly (GO:0070286)	5.51054505
15	plasma membrane fusion (GO:0045026)	5.32019195
16	cell-cell recognition (GO:0009988)	5.16812043
17	regulation of cilium movement (GO:0003352)	5.08689981
18	calcium ion-dependent exocytosis (GO:0017156)	4.98679751
19	organic cation transport (GO:0015695)	4.95961705
20	coenzyme catabolic process (GO:0009109)	4.84844313
21	protein polyglutamylation (GO:0018095)	4.82570813
22	single fertilization (GO:0007338)	4.74174200
23	microtubule depolymerization (GO:0007019)	4.67550621
24	response to muscle activity (GO:0014850)	4.64483257
25	cilium or flagellum-dependent cell motility (GO:0001539)	4.59392365
26	rRNA methylation (GO:0031167)	4.59314785
27	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.54044997
28	epithelial cilium movement (GO:0003351)	4.53360595
29	response to pheromone (GO:0019236)	4.41868124
30	sperm capacitation (GO:0048240)	4.39678688
31	germ cell development (GO:0007281)	4.38151452
32	phosphatidylethanolamine metabolic process (GO:0046337)	4.34504300
33	polyamine biosynthetic process (GO:0006596)	4.26252728
34	relaxation of smooth muscle (GO:0044557)	4.23641517
35	spermatid nucleus differentiation (GO:0007289)	4.21280528
36	centriole assembly (GO:0098534)	4.09694315
37	rRNA modification (GO:0000154)	4.07103140
38	spermatogenesis (GO:0007283)	3.98399560
39	male gamete generation (GO:0048232)	3.96978575
40	protein targeting to Golgi (GO:0000042)	3.81843540
41	mitochondrion degradation (GO:0000422)	3.78786257
42	TOR signaling (GO:0031929)	3.76256456
43	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.75219232
44	establishment of protein localization to Golgi (GO:0072600)	3.74870448
45	potassium ion export (GO:0071435)	3.74770054
46	regulation of oxidative phosphorylation (GO:0002082)	3.71371387
47	centriole replication (GO:0007099)	3.68028783
48	cilium movement (GO:0003341)	3.67313601
49	gamete generation (GO:0007276)	3.66760977
50	synapsis (GO:0007129)	3.65788238
51	protein-DNA complex disassembly (GO:0032986)	3.65679592
52	nucleosome disassembly (GO:0006337)	3.65679592
53	negative regulation of inclusion body assembly (GO:0090084)	3.65170048
54	positive regulation of action potential (GO:0045760)	3.64131140
55	chromosome condensation (GO:0030261)	3.63594537
56	positive regulation of glycolytic process (GO:0045821)	3.61891778
57	microtubule polymerization or depolymerization (GO:0031109)	3.58328133
58	fertilization (GO:0009566)	3.58195460
59	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.56635858
60	single strand break repair (GO:0000012)	3.56591495
61	regulation of microtubule-based movement (GO:0060632)	3.50757619
62	DNA packaging (GO:0006323)	3.49418249
63	cellular ketone body metabolic process (GO:0046950)	3.47485471
64	regulation of dopamine secretion (GO:0014059)	3.41158700
65	urinary tract smooth muscle contraction (GO:0014848)	3.38428116
66	ketone body metabolic process (GO:1902224)	3.37169007
67	tachykinin receptor signaling pathway (GO:0007217)	3.31602150
68	activation of protein kinase B activity (GO:0032148)	3.29504850
69	acrosome assembly (GO:0001675)	3.27245782
70	DNA double-strand break processing (GO:0000729)	3.20776838
71	histone exchange (GO:0043486)	3.18899016
72	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.17753338
73	piRNA metabolic process (GO:0034587)	3.13531193
74	amine biosynthetic process (GO:0009309)	3.11019966
75	cGMP-mediated signaling (GO:0019934)	3.09702300
76	negative regulation of reactive oxygen species metabolic process (GO:2000378)	3.08507621
77	cellular biogenic amine biosynthetic process (GO:0042401)	3.06856007
78	response to acidic pH (GO:0010447)	3.06738034
79	regulation of cellular respiration (GO:0043457)	3.01879769
80	ventricular system development (GO:0021591)	3.01710373
81	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.00380221
82	aspartate family amino acid catabolic process (GO:0009068)	2.99355534
83	cellular response to toxic substance (GO:0097237)	2.95642183
84	multicellular organismal reproductive process (GO:0048609)	2.94872990
85	regulation of synaptic transmission, dopaminergic (GO:0032225)	2.91565855
86	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.89462018
87	photoreceptor cell maintenance (GO:0045494)	2.86658494
88	regulation of action potential (GO:0098900)	2.86064298
89	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	2.85070744
90	microtubule severing (GO:0051013)	2.83353935
91	ADP metabolic process (GO:0046031)	2.81246794
92	negative regulation of Rho protein signal transduction (GO:0035024)	2.76241440
93	androgen biosynthetic process (GO:0006702)	2.75084398
94	protein localization to Golgi apparatus (GO:0034067)	2.72089367
95	axoneme assembly (GO:0035082)	2.71997402
96	polyamine metabolic process (GO:0006595)	2.71097457
97	Leydig cell differentiation (GO:0033327)	2.70192170
98	glutamine family amino acid catabolic process (GO:0009065)	2.69795847
99	meiotic nuclear division (GO:0007126)	2.67692232
100	acrosome reaction (GO:0007340)	10.0221675

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.68882505
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.13146754
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.31917851
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.12535702
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.91857190
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.88928922
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.73549944
8	VDR_22108803_ChIP-Seq_LS180_Human	2.52611180
9	FUS_26573619_Chip-Seq_HEK293_Human	2.52444356
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.41118753
11	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.39699442
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.36614124
13	ER_23166858_ChIP-Seq_MCF-7_Human	2.34534579
14	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.30781884
15	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.30781884
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.22506031
17	CBP_20019798_ChIP-Seq_JUKART_Human	2.21113902
18	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.21113902
19	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.17994513
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.11523298
21	P300_19829295_ChIP-Seq_ESCs_Human	1.90801393
22	NANOG_20526341_ChIP-Seq_ESCs_Human	1.78942176
23	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.77993128
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.69185397
25	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.60641623
26	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.59268135
27	MYC_19829295_ChIP-Seq_ESCs_Human	1.57672757
28	AR_21572438_ChIP-Seq_LNCaP_Human	1.56932886
29	RAC3_21632823_ChIP-Seq_H3396_Human	1.54083920
30	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.52785782
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51582310
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51195074
33	AR_25329375_ChIP-Seq_VCAP_Human	1.50071622
34	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.49111529
35	ERA_21632823_ChIP-Seq_H3396_Human	1.48844333
36	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.48048127
37	SMAD4_21799915_ChIP-Seq_A2780_Human	1.46649298
38	OCT4_20526341_ChIP-Seq_ESCs_Human	1.45876591
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.42855504
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.42855504
41	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.42768772
42	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.40616313
43	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.39189679
44	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.38813348
45	RUNX2_22187159_ChIP-Seq_PCA_Human	1.36517542
46	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.35804093
47	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.35655888
48	TBL1_22424771_ChIP-Seq_293T_Human	1.35650269
49	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.35353982
50	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.34994463
51	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.34719822
52	STAT3_23295773_ChIP-Seq_U87_Human	1.32209687
53	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.30984927
54	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.30128993
55	HOXB7_26014856_ChIP-Seq_BT474_Human	1.28729779
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.25856654
57	IRF1_19129219_ChIP-ChIP_H3396_Human	1.25762192
58	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25531611
59	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.23133575
60	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22641165
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21743130
62	ERG_20517297_ChIP-Seq_VCAP_Human	1.20289893
63	TAF15_26573619_Chip-Seq_HEK293_Human	1.20063199
64	AHR_22903824_ChIP-Seq_MCF-7_Human	1.19279631
65	BCAT_22108803_ChIP-Seq_LS180_Human	1.16467645
66	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.16434139
67	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.15259314
68	RXR_22108803_ChIP-Seq_LS180_Human	1.13643920
69	NFYB_21822215_ChIP-Seq_K562_Human	1.13533310
70	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.13395433
71	PHF8_20622853_ChIP-Seq_HELA_Human	1.13294773
72	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.13113660
73	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08152772
74	TCF4_23295773_ChIP-Seq_U87_Human	1.07646312
75	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07438717
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.07263050
77	TCF4_22108803_ChIP-Seq_LS180_Human	1.07076104
78	CTCF_27219007_Chip-Seq_Bcells_Human	1.06493812
79	NFYA_21822215_ChIP-Seq_K562_Human	1.06203887
80	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05758082
81	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.05257160
82	NCOR_22424771_ChIP-Seq_293T_Human	1.04977118
83	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.04964619
84	ETV1_20927104_ChIP-Seq_GIST48_Human	1.03258987
85	RBPJ_21746931_ChIP-Seq_IB4_Human	1.02809415
86	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.02715150
87	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.00961045
88	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.00599428
89	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.99860744
90	P300_27268052_Chip-Seq_Bcells_Human	0.99079349
91	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.96737454
92	DROSHA_22980978_ChIP-Seq_HELA_Human	0.96219043
93	GATA3_26560356_Chip-Seq_TH1_Human	0.96211812
94	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.95421053
95	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.94478376
96	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.94009048
97	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.93834273
98	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.93826140
99	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.93036787
100	TAF2_19829295_ChIP-Seq_ESCs_Human	0.92934025

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	8.76487529
2	MP0004084_abnormal_cardiac_muscle	3.82387829
3	MP0008004_abnormal_stomach_pH	3.41291250
4	MP0003646_muscle_fatigue	3.14332199
5	MP0003698_abnormal_male_reproductive	3.13850621
6	MP0001968_abnormal_touch/_nociception	2.87841831
7	MP0002837_dystrophic_cardiac_calcinosis	2.82023085
8	MP0001929_abnormal_gametogenesis	2.80599400
9	MP0003315_abnormal_perineum_morphology	2.71611051
10	MP0002736_abnormal_nociception_after	2.69084818
11	MP0001984_abnormal_olfaction	2.54409415
12	MP0001529_abnormal_vocalization	2.48212410
13	MP0004036_abnormal_muscle_relaxation	2.40281812
14	MP0000749_muscle_degeneration	2.30079974
15	MP0009697_abnormal_copulation	2.22599820
16	MP0005377_hearing/vestibular/ear_phenot	2.17285189
17	MP0003878_abnormal_ear_physiology	2.17285189
18	MP0003718_maternal_effect	2.04657415
19	MP0005360_urolithiasis	2.00495550
20	MP0003136_yellow_coat_color	1.96752841
21	MP0002160_abnormal_reproductive_system	1.93993732
22	MP0004215_abnormal_myocardial_fiber	1.88734075
23	MP0002132_abnormal_respiratory_system	1.81775704
24	MP0003806_abnormal_nucleotide_metabolis	1.78121398
25	MP0008775_abnormal_heart_ventricle	1.76528395
26	MP0005253_abnormal_eye_physiology	1.71681343
27	MP0002127_abnormal_cardiovascular_syste	1.68504073
28	MP0005167_abnormal_blood-brain_barrier	1.65813742
29	MP0001905_abnormal_dopamine_level	1.59109888
30	MP0001501_abnormal_sleep_pattern	1.55058463
31	MP0002161_abnormal_fertility/fecundity	1.51497001
32	MP0006072_abnormal_retinal_apoptosis	1.51464494
33	MP0002735_abnormal_chemical_nociception	1.46417946
34	MP0002138_abnormal_hepatobiliary_system	1.42033884
35	MP0002102_abnormal_ear_morphology	1.39148573
36	MP0002210_abnormal_sex_determination	1.38166076
37	MP0005394_taste/olfaction_phenotype	1.35245942
38	MP0005499_abnormal_olfactory_system	1.35245942
39	MP0005551_abnormal_eye_electrophysiolog	1.33581383
40	MP0010368_abnormal_lymphatic_system	1.31621864
41	MP0005647_abnormal_sex_gland	1.29651547
42	MP0001485_abnormal_pinna_reflex	1.28729173
43	MP0004484_altered_response_of	1.27128590
44	MP0001486_abnormal_startle_reflex	1.27011506
45	MP0006036_abnormal_mitochondrial_physio	1.22497257
46	MP0000372_irregular_coat_pigmentation	1.20343217
47	MP0001145_abnormal_male_reproductive	1.19559738
48	MP0003045_fibrosis	1.18212909
49	MP0001664_abnormal_digestion	1.12933862
50	MP0004085_abnormal_heartbeat	1.11204018
51	MP0005670_abnormal_white_adipose	1.10873090
52	MP0005646_abnormal_pituitary_gland	1.09365939
53	MP0000653_abnormal_sex_gland	1.08951121
54	MP0008789_abnormal_olfactory_epithelium	1.06057708
55	MP0002272_abnormal_nervous_system	1.05765703
56	MP0002067_abnormal_sensory_capabilities	1.05107112
57	MP0008007_abnormal_cellular_replicative	1.00786033
58	MP0005395_other_phenotype	0.97600714
59	MP0005389_reproductive_system_phenotype	0.97177493
60	MP0005620_abnormal_muscle_contractility	0.91380319
61	MP0008995_early_reproductive_senescence	0.91335789
62	MP0004145_abnormal_muscle_electrophysio	0.91037673
63	MP0004742_abnormal_vestibular_system	0.85669327
64	MP0005330_cardiomyopathy	0.85283681
65	MP0009046_muscle_twitch	0.82837280
66	MP0002269_muscular_atrophy	0.80977841
67	MP0003137_abnormal_impulse_conducting	0.79394568
68	MP0002282_abnormal_trachea_morphology	0.77606125
69	MP0008872_abnormal_physiological_respon	0.76827970
70	MP0002572_abnormal_emotion/affect_behav	0.76785016
71	MP0001963_abnormal_hearing_physiology	0.76573334
72	MP0003633_abnormal_nervous_system	0.75467551
73	MP0000230_abnormal_systemic_arterial	0.75261460
74	MP0005386_behavior/neurological_phenoty	0.75174718
75	MP0004924_abnormal_behavior	0.75174718
76	MP0003631_nervous_system_phenotype	0.75043691
77	MP0000343_altered_response_to	0.74844172
78	MP0009745_abnormal_behavioral_response	0.73956225
79	MP0000470_abnormal_stomach_morphology	0.71945736
80	MP0004782_abnormal_surfactant_physiolog	0.70436168
81	MP0005187_abnormal_penis_morphology	0.69269295
82	MP0008877_abnormal_DNA_methylation	0.69213331
83	MP0003635_abnormal_synaptic_transmissio	0.68139883
84	MP0002229_neurodegeneration	0.67093291
85	MP0010386_abnormal_urinary_bladder	0.66653587
86	MP0006138_congestive_heart_failure	0.65669480
87	MP0002733_abnormal_thermal_nociception	0.63655453
88	MP0002277_abnormal_respiratory_mucosa	0.62735850
89	MP0001970_abnormal_pain_threshold	0.62411359
90	MP0003011_delayed_dark_adaptation	0.61256800
91	MP0004233_abnormal_muscle_weight	0.61142188
92	MP0002108_abnormal_muscle_morphology	0.57959684
93	MP0003950_abnormal_plasma_membrane	0.57628183
94	MP0000538_abnormal_urinary_bladder	0.56777671
95	MP0001544_abnormal_cardiovascular_syste	0.56714920
96	MP0005385_cardiovascular_system_phenoty	0.56714920
97	MP0005391_vision/eye_phenotype	0.55213346
98	MP0003632_abnormal_nervous_system	0.50616074
99	MP0002972_abnormal_cardiac_muscle	0.50461590
100	MP0002752_abnormal_somatic_nervous	0.50408974

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Resting tremor (HP:0002322)	5.01930604
2	Absent/shortened dynein arms (HP:0200106)	4.81006012
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.81006012
4	Type II lissencephaly (HP:0007260)	4.55722092
5	Cerebellar dysplasia (HP:0007033)	4.16029680
6	Retinal dysplasia (HP:0007973)	4.12737337
7	Abnormal ciliary motility (HP:0012262)	4.11072902
8	Hypoplasia of the uterus (HP:0000013)	4.07884562
9	Clumsiness (HP:0002312)	4.07168399
10	Abnormal respiratory motile cilium physiology (HP:0012261)	3.92026149
11	Tubulointerstitial nephritis (HP:0001970)	3.83760418
12	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.68371737
13	Abnormal respiratory motile cilium morphology (HP:0005938)	3.61871435
14	Abnormal respiratory epithelium morphology (HP:0012253)	3.61871435
15	Aplasia/hypoplasia of the uterus (HP:0008684)	3.47949371
16	Postural instability (HP:0002172)	3.45027234
17	Congenital sensorineural hearing impairment (HP:0008527)	3.38357151
18	Abnormal sex determination (HP:0012244)	3.36093121
19	Sex reversal (HP:0012245)	3.36093121
20	Chronic hepatic failure (HP:0100626)	3.26055617
21	Attenuation of retinal blood vessels (HP:0007843)	3.25836832
22	Infertility (HP:0000789)	3.24415437
23	Reduced antithrombin III activity (HP:0001976)	3.12113870
24	Inability to walk (HP:0002540)	3.08214032
25	Gonadal dysgenesis (HP:0000133)	2.96551867
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.95999207
27	Protruding tongue (HP:0010808)	2.89565819
28	Hyperkalemia (HP:0002153)	2.84733962
29	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.81673683
30	Male pseudohermaphroditism (HP:0000037)	2.78644292
31	Abnormality of the columella (HP:0009929)	2.61789751
32	Abnormality of macular pigmentation (HP:0008002)	2.55989116
33	Eosinophilia (HP:0001880)	2.54726309
34	Ventricular fibrillation (HP:0001663)	2.48166635
35	Renal cortical cysts (HP:0000803)	2.43976731
36	Abnormal drinking behavior (HP:0030082)	2.43685465
37	Polydipsia (HP:0001959)	2.43685465
38	Colitis (HP:0002583)	2.40580380
39	Anterior segment dysgenesis (HP:0007700)	2.40024186
40	Abnormality of the renal cortex (HP:0011035)	2.39298076
41	Absent speech (HP:0001344)	2.38532032
42	Atonic seizures (HP:0010819)	2.37134155
43	Bony spicule pigmentary retinopathy (HP:0007737)	2.36981084
44	Severe visual impairment (HP:0001141)	2.34179580
45	Prolonged QT interval (HP:0001657)	2.30217937
46	Abnormality of eosinophils (HP:0001879)	2.26030036
47	Germ cell neoplasia (HP:0100728)	2.25853333
48	Abolished electroretinogram (ERG) (HP:0000550)	2.23354808
49	Decreased central vision (HP:0007663)	2.21588309
50	Pancreatic cysts (HP:0001737)	2.20775105
51	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.20741224
52	Hyporeflexia of lower limbs (HP:0002600)	2.20296092
53	Rhinitis (HP:0012384)	2.18207455
54	Syncope (HP:0001279)	2.16120796
55	Abnormality of the ileum (HP:0001549)	2.15782437
56	Abnormality of the renal medulla (HP:0100957)	2.13474303
57	Enlarged kidneys (HP:0000105)	2.12218461
58	Abnormal EKG (HP:0003115)	2.11617856
59	Myoglobinuria (HP:0002913)	2.09808686
60	Median cleft lip (HP:0000161)	2.06271109
61	Generalized aminoaciduria (HP:0002909)	2.05075874
62	Sensory axonal neuropathy (HP:0003390)	2.03972883
63	Exercise-induced muscle cramps (HP:0003710)	2.03409797
64	Nephronophthisis (HP:0000090)	2.03321517
65	Bulbous nose (HP:0000414)	2.03130714
66	Meckel diverticulum (HP:0002245)	2.02938310
67	Azoospermia (HP:0000027)	2.02307519
68	Occipital encephalocele (HP:0002085)	2.00329632
69	Clubbing of toes (HP:0100760)	1.99805369
70	Broad-based gait (HP:0002136)	1.98505172
71	Optic nerve hypoplasia (HP:0000609)	1.98463266
72	Congenital stationary night blindness (HP:0007642)	1.95467203
73	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.94336909
74	Exercise-induced myalgia (HP:0003738)	1.93639307
75	Abnormality of lateral ventricle (HP:0030047)	1.93565886
76	Facial hemangioma (HP:0000329)	1.90677061
77	Urinary urgency (HP:0000012)	1.87998134
78	Pancreatic fibrosis (HP:0100732)	1.87804023
79	Abnormal urine output (HP:0012590)	1.87222949
80	Rhabdomyolysis (HP:0003201)	1.87203289
81	Polyuria (HP:0000103)	1.87069739
82	Granulocytopenia (HP:0001913)	1.82939348
83	Molar tooth sign on MRI (HP:0002419)	1.81632291
84	Abnormality of midbrain morphology (HP:0002418)	1.81632291
85	Delayed CNS myelination (HP:0002188)	1.81353035
86	Atrial fibrillation (HP:0005110)	1.81163475
87	Nasal polyposis (HP:0100582)	1.80039886
88	Muscle hypertrophy of the lower extremities (HP:0008968)	1.79867464
89	Calf muscle hypertrophy (HP:0008981)	1.79413581
90	Fair hair (HP:0002286)	1.77704035
91	Hypothermia (HP:0002045)	1.75989619
92	Abnormal spermatogenesis (HP:0008669)	1.74589421
93	Retinal atrophy (HP:0001105)	1.73967805
94	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.73786348
95	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.73786348
96	True hermaphroditism (HP:0010459)	1.70152755
97	Bronchiectasis (HP:0002110)	1.68678100
98	Renal dysplasia (HP:0000110)	1.68566925
99	Facial diplegia (HP:0001349)	1.68307611
100	Primary atrial arrhythmia (HP:0001692)	1.68271654

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK3	4.17592215
2	ZAK	3.25889165
3	PLK4	2.91689426
4	FRK	2.57057966
5	OBSCN	2.52169160
6	TLK1	2.36236824
7	ADRBK2	2.23861929
8	BMPR1B	2.10285893
9	STK38	2.05429940
10	PINK1	10.2031346
11	STK38L	1.82502971
12	PLK2	1.81143889
13	LATS1	1.70059821
14	RPS6KA5	1.64232620
15	PTK2B	1.62289174
16	MYLK	1.58682954
17	MAPK13	1.57699049
18	MAP2K7	1.46954204
19	GRK1	1.43412009
20	INSRR	1.38800869
21	NEK2	1.34083464
22	WNK4	1.30904570
23	CSNK1A1L	1.10511839
24	EIF2AK3	1.08161302
25	TIE1	1.07611740
26	MET	1.04708935
27	MAP4K2	1.02997198
28	CDK3	0.98671325
29	CSNK1G3	0.95285583
30	VRK1	0.92433051
31	WNK3	0.91142033
32	MAPK15	0.91102802
33	PRKCQ	0.90555257
34	PHKG2	0.89341551
35	PHKG1	0.89341551
36	PRKG2	0.88673447
37	CCNB1	0.85526386
38	CSNK1G1	0.85314885
39	PKN1	0.83102806
40	MST1R	0.82203543
41	ROCK1	0.80579851
42	ARAF	0.79790503
43	TAOK3	0.78386100
44	CSNK1G2	0.77902433
45	NUAK1	0.76492470
46	SGK494	0.75336334
47	SGK223	0.75336334
48	TNIK	0.67990801
49	DYRK2	0.66088486
50	PRKG1	0.56807881
51	PRKCE	0.56596100
52	STK4	0.52038650
53	FLT3	0.52010139
54	MUSK	0.49118156
55	RPS6KB1	0.48940706
56	PDK1	0.48034955
57	CAMKK2	0.46757756
58	STK3	0.45559410
59	TGFBR1	0.44529328
60	DDR2	0.44156760
61	PDPK1	0.43604848
62	MAP3K1	0.43201176
63	FES	0.42695005
64	WNK1	0.41526689
65	BCKDK	0.40727482
66	MAPK12	0.40610463
67	ATM	0.40583444
68	FGFR2	0.39248972
69	KDR	0.36539310
70	TESK1	0.36421177
71	RPS6KA1	0.36053557
72	CDK14	0.35739829
73	DAPK3	0.35586026
74	CSNK1A1	0.34956068
75	TEC	0.34948708
76	BRSK2	0.34404099
77	CAMK1	0.33468060
78	GRK5	0.32354246
79	CSNK1D	0.31519222
80	KIT	0.30694360
81	SYK	0.30387525
82	PAK3	0.30113119
83	EGFR	0.29765152
84	PRKCG	0.29619838
85	PIK3CG	0.28113462
86	PLK3	0.26965609
87	CAMK2D	0.26680036
88	PRKACA	0.26540022
89	MAP3K5	0.25688694
90	MARK1	0.24779959
91	BTK	0.24596317
92	TXK	0.24115204
93	SRPK1	0.24104575
94	PAK1	0.23993948
95	CAMK2A	0.23440781
96	CDK5	0.21743054
97	ADRBK1	0.21236722
98	NEK6	0.20363175
99	PRKAA2	0.19996266
100	MAP3K11	0.18670633

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.02953485
2	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	3.85945004
3	Olfactory transduction_Homo sapiens_hsa04740	3.31703818
4	Nitrogen metabolism_Homo sapiens_hsa00910	3.17272126
5	Butanoate metabolism_Homo sapiens_hsa00650	2.89923789
6	Gap junction_Homo sapiens_hsa04540	2.62669714
7	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.60514044
8	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	2.42668291
9	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.23795269
10	Arginine biosynthesis_Homo sapiens_hsa00220	2.09332867
11	Propanoate metabolism_Homo sapiens_hsa00640	1.97443549
12	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.91288382
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.86069232
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.71205584
15	Taste transduction_Homo sapiens_hsa04742	1.69582591
16	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.50937962
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.48580649
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.43114380
19	Phototransduction_Homo sapiens_hsa04744	1.41697613
20	Allograft rejection_Homo sapiens_hsa05330	1.37701324
21	Alcoholism_Homo sapiens_hsa05034	1.34767242
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.33144330
23	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.32522692
24	Graft-versus-host disease_Homo sapiens_hsa05332	1.31640342
25	Regulation of autophagy_Homo sapiens_hsa04140	1.29159852
26	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.25290677
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.24781401
28	Phagosome_Homo sapiens_hsa04145	1.23616710
29	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.23297258
30	Type I diabetes mellitus_Homo sapiens_hsa04940	1.21839306
31	Calcium signaling pathway_Homo sapiens_hsa04020	1.21321201
32	Basal transcription factors_Homo sapiens_hsa03022	1.18432776
33	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.18022740
34	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.16546461
35	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.12672811
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.11372278
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.11147866
38	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.10594743
39	Purine metabolism_Homo sapiens_hsa00230	1.06810579
40	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.05996120
41	Cardiac muscle contraction_Homo sapiens_hsa04260	1.03367675
42	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.02325055
43	Apoptosis_Homo sapiens_hsa04210	0.97811709
44	Linoleic acid metabolism_Homo sapiens_hsa00591	0.96347540
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.95908331
46	Asthma_Homo sapiens_hsa05310	0.93611744
47	Arginine and proline metabolism_Homo sapiens_hsa00330	0.92549598
48	Circadian entrainment_Homo sapiens_hsa04713	0.91350973
49	Oocyte meiosis_Homo sapiens_hsa04114	0.91205085
50	Selenocompound metabolism_Homo sapiens_hsa00450	0.91006703
51	Fatty acid degradation_Homo sapiens_hsa00071	0.90976346
52	Peroxisome_Homo sapiens_hsa04146	0.89561726
53	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.89148564
54	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.88340822
55	Antigen processing and presentation_Homo sapiens_hsa04612	0.88083764
56	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.86184300
57	Glutathione metabolism_Homo sapiens_hsa00480	0.85320149
58	Renin secretion_Homo sapiens_hsa04924	0.83218436
59	Salivary secretion_Homo sapiens_hsa04970	0.81743786
60	Circadian rhythm_Homo sapiens_hsa04710	0.80278867
61	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.78872803
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.78638775
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.78208394
64	ABC transporters_Homo sapiens_hsa02010	0.74297631
65	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.72007500
66	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.71877130
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70966797
68	PPAR signaling pathway_Homo sapiens_hsa03320	0.70167685
69	Retinol metabolism_Homo sapiens_hsa00830	0.66410903
70	RNA degradation_Homo sapiens_hsa03018	0.64995886
71	Gastric acid secretion_Homo sapiens_hsa04971	0.63897228
72	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.59873120
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.59585634
74	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.59263554
75	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.59151131
76	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58921655
77	Tryptophan metabolism_Homo sapiens_hsa00380	0.58887438
78	Pyruvate metabolism_Homo sapiens_hsa00620	0.56113671
79	Glucagon signaling pathway_Homo sapiens_hsa04922	0.54602143
80	Glutamatergic synapse_Homo sapiens_hsa04724	0.53777976
81	Fatty acid metabolism_Homo sapiens_hsa01212	0.53495661
82	Nicotine addiction_Homo sapiens_hsa05033	0.51823540
83	Morphine addiction_Homo sapiens_hsa05032	0.48919787
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.48417216
85	Type II diabetes mellitus_Homo sapiens_hsa04930	0.45762053
86	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.44917312
87	Phenylalanine metabolism_Homo sapiens_hsa00360	0.43383687
88	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.41157929
89	Platelet activation_Homo sapiens_hsa04611	0.41123617
90	Tyrosine metabolism_Homo sapiens_hsa00350	0.39835279
91	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.37184861
92	RNA transport_Homo sapiens_hsa03013	0.36178561
93	Metabolic pathways_Homo sapiens_hsa01100	0.33413065
94	Homologous recombination_Homo sapiens_hsa03440	0.31890490
95	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.30781686
96	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.30127016
97	Viral myocarditis_Homo sapiens_hsa05416	0.29380896
98	Parkinsons disease_Homo sapiens_hsa05012	0.27542225
99	Serotonergic synapse_Homo sapiens_hsa04726	0.26227246
100	GABAergic synapse_Homo sapiens_hsa04727	0.26082500

LINC00521

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »