ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synaptic vesicle maturation (GO:0016188)	8.22458073
2	synaptic vesicle docking involved in exocytosis (GO:0016081)	7.40895575
3	glutamate secretion (GO:0014047)	7.03134186
4	regulation of short-term neuronal synaptic plasticity (GO:0048172)	6.73670264
5	synaptic vesicle exocytosis (GO:0016079)	6.52560455
6	regulation of synaptic vesicle exocytosis (GO:2000300)	6.20992690
7	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	5.76351144
8	cellular potassium ion homeostasis (GO:0030007)	5.63245986
9	postsynaptic membrane organization (GO:0001941)	5.56899498
10	neurotransmitter secretion (GO:0007269)	5.38975111
11	regulation of synaptic vesicle transport (GO:1902803)	5.31804978
12	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	5.28780801
13	locomotory exploration behavior (GO:0035641)	5.26537288
14	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	5.24339918
15	vocalization behavior (GO:0071625)	5.24071871
16	ionotropic glutamate receptor signaling pathway (GO:0035235)	5.04332083
17	L-amino acid import (GO:0043092)	5.03944846
18	neuron cell-cell adhesion (GO:0007158)	5.03830416
19	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	4.99359464
20	protein localization to synapse (GO:0035418)	4.94389606
21	regulation of neuronal synaptic plasticity (GO:0048168)	4.91090063
22	exploration behavior (GO:0035640)	4.84251767
23	gamma-aminobutyric acid transport (GO:0015812)	4.82730412
24	sodium ion export (GO:0071436)	4.73007089
25	synaptic transmission, glutamatergic (GO:0035249)	4.59390943
26	positive regulation of synapse maturation (GO:0090129)	4.58444449
27	amino acid import (GO:0043090)	4.56533792
28	regulation of synapse structural plasticity (GO:0051823)	4.52633562
29	layer formation in cerebral cortex (GO:0021819)	4.49095118
30	neurotransmitter-gated ion channel clustering (GO:0072578)	4.47453025
31	dendritic spine morphogenesis (GO:0060997)	4.44891194
32	cerebellar granule cell differentiation (GO:0021707)	4.44697818
33	regulation of glutamate receptor signaling pathway (GO:1900449)	4.38551152
34	neurotransmitter transport (GO:0006836)	4.28644990
35	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.28469931
36	regulation of long-term neuronal synaptic plasticity (GO:0048169)	4.25751035
37	neuronal action potential propagation (GO:0019227)	4.18465464
38	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	4.09803305
39	potassium ion homeostasis (GO:0055075)	4.09573094
40	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	4.07242670
41	regulation of dendritic spine morphogenesis (GO:0061001)	4.06719002
42	positive regulation of dendritic spine development (GO:0060999)	3.99931186
43	regulation of neurotransmitter levels (GO:0001505)	3.98850547
44	synaptic vesicle endocytosis (GO:0048488)	3.95441502
45	axon ensheathment in central nervous system (GO:0032291)	3.94179691
46	central nervous system myelination (GO:0022010)	3.94179691
47	neuronal ion channel clustering (GO:0045161)	3.93352621
48	positive regulation of membrane potential (GO:0045838)	3.92399875
49	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.89090923
50	regulation of neurotransmitter secretion (GO:0046928)	3.89038818
51	auditory behavior (GO:0031223)	3.86450244
52	regulation of voltage-gated calcium channel activity (GO:1901385)	3.83890145
53	glutamate receptor signaling pathway (GO:0007215)	3.83521857
54	regulation of excitatory postsynaptic membrane potential (GO:0060079)	3.83324156
55	neuron-neuron synaptic transmission (GO:0007270)	3.82832114
56	acidic amino acid transport (GO:0015800)	3.80957764
57	regulation of synaptic plasticity (GO:0048167)	3.78132474
58	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	3.76808947
59	dendritic spine organization (GO:0097061)	3.76782198
60	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.76354545
61	axonal fasciculation (GO:0007413)	3.75849339
62	presynaptic membrane assembly (GO:0097105)	3.74762200
63	potassium ion import (GO:0010107)	3.73863721
64	neuromuscular process controlling balance (GO:0050885)	3.72021263
65	cerebellar Purkinje cell differentiation (GO:0021702)	3.68819397
66	regulation of postsynaptic membrane potential (GO:0060078)	3.57526537
67	regulation of dendritic spine development (GO:0060998)	3.56921412
68	cell migration in hindbrain (GO:0021535)	3.56800046
69	regulation of neurotransmitter transport (GO:0051588)	3.55330198
70	regulation of synapse maturation (GO:0090128)	3.54045913
71	presynaptic membrane organization (GO:0097090)	3.52765141
72	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.52092629
73	establishment of mitochondrion localization (GO:0051654)	3.45448979
74	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.43827593
75	L-glutamate transport (GO:0015813)	3.40033370
76	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.36358186
77	proline transport (GO:0015824)	3.36355505
78	positive regulation of neurotransmitter secretion (GO:0001956)	3.36147436
79	neuron recognition (GO:0008038)	3.35925221
80	response to auditory stimulus (GO:0010996)	3.34270759
81	transmission of nerve impulse (GO:0019226)	3.33004644
82	positive regulation of neurotransmitter transport (GO:0051590)	3.31028365
83	regulation of vesicle fusion (GO:0031338)	3.28627114
84	membrane depolarization (GO:0051899)	3.25256577
85	negative regulation of dendrite morphogenesis (GO:0050774)	3.24288154
86	regulation of ARF protein signal transduction (GO:0032012)	3.23738637
87	long-term memory (GO:0007616)	3.23646366
88	neuromuscular synaptic transmission (GO:0007274)	3.22836079
89	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.20121092
90	neurotransmitter uptake (GO:0001504)	3.18130979
91	regulation of synaptic transmission (GO:0050804)	3.15315832
92	cellular sodium ion homeostasis (GO:0006883)	3.15171277
93	mechanosensory behavior (GO:0007638)	3.12513465
94	synaptic transmission (GO:0007268)	3.12099577
95	regulation of dendrite morphogenesis (GO:0048814)	3.11122238
96	membrane depolarization during action potential (GO:0086010)	3.09367269
97	cell communication by electrical coupling (GO:0010644)	3.07823110
98	establishment of synaptic vesicle localization (GO:0097480)	3.07457476
99	synaptic vesicle transport (GO:0048489)	3.07457476
100	regulation of respiratory system process (GO:0044065)	3.06023505

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.45122961
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	4.28342640
3	REST_21632747_ChIP-Seq_MESCs_Mouse	3.45416454
4	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	3.27607332
5	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	3.25434507
6	JARID2_20064375_ChIP-Seq_MESCs_Mouse	3.21859795
7	RARB_27405468_Chip-Seq_BRAIN_Mouse	3.21198519
8	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	3.07233902
9	EZH2_27304074_Chip-Seq_ESCs_Mouse	3.02524075
10	JARID2_20075857_ChIP-Seq_MESCs_Mouse	3.01545290
11	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.97655961
12	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.97655961
13	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.94620108
14	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.94137773
15	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	2.84388796
16	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.82766732
17	DROSHA_22980978_ChIP-Seq_HELA_Human	2.81496451
18	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.75687854
19	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.70450060
20	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.69995559
21	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.66907797
22	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.66459157
23	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.66179703
24	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.56838792
25	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.42811162
26	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.42301374
27	GBX2_23144817_ChIP-Seq_PC3_Human	2.09820075
28	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.09445382
29	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	2.06806113
30	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.06239701
31	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	2.00639838
32	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.84073874
33	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.75404949
34	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.72409676
35	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.71549066
36	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.67740439
37	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.65098568
38	KDM2B_26808549_Chip-Seq_K562_Human	1.64779176
39	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.59634120
40	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.52447065
41	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.51683429
42	RNF2_27304074_Chip-Seq_NSC_Mouse	1.50252119
43	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.37860330
44	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.37533881
45	CTCF_27219007_Chip-Seq_Bcells_Human	1.36859871
46	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.29232203
47	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.29119209
48	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.28677118
49	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.27067673
50	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.26835006
51	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.26281449
52	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.25059763
53	LXR_22292898_ChIP-Seq_THP-1_Human	1.24833575
54	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.21325068
55	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.18800294
56	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.18799792
57	AR_21572438_ChIP-Seq_LNCaP_Human	1.17910240
58	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.12929121
59	AR_19668381_ChIP-Seq_PC3_Human	1.09641273
60	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.08797669
61	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07148855
62	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.04252250
63	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.02541766
64	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.02377408
65	OCT4_19829295_ChIP-Seq_ESCs_Human	0.99290004
66	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.97622226
67	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.94399771
68	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.93569051
69	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.93052942
70	SMC4_20622854_ChIP-Seq_HELA_Human	0.92495388
71	CREB1_26743006_Chip-Seq_LNCaP_Human	0.92018588
72	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.90411969
73	DPY_21335234_ChIP-Seq_ESCs_Mouse	0.89488446
74	P68_20966046_ChIP-Seq_HELA_Human	0.89041839
75	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.85348217
76	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.85124472
77	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.83917546
78	RUNX1_26923725_Chip-Seq_HPCs_Mouse	0.82242510
79	KLF4_19829295_ChIP-Seq_ESCs_Human	0.81949305
80	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	0.81267120
81	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.81172703
82	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.80611324
83	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.79441763
84	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.78527004
85	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.78261474
86	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.76449202
87	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.75146666
88	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.71883213
89	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.70677916
90	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.70677916
91	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.69246722
92	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.68240903
93	SMAD4_21741376_ChIP-Seq_ESCs_Human	0.68022394
94	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.67691001
95	SOX3_22085726_ChIP-Seq_NPCs_Mouse	0.66728059
96	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.66682242
97	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.66083942
98	MYC_19915707_ChIP-ChIP_AK7_Human	0.65783256
99	POU3F1_26484290_ChIP-Seq_ESCss_Mouse	0.65716746
100	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.65521788

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	6.59020201
2	MP0003880_abnormal_central_pattern	4.98107733
3	MP0004270_analgesia	4.40750038
4	MP0005423_abnormal_somatic_nervous	4.21543631
5	MP0003635_abnormal_synaptic_transmissio	4.08869029
6	MP0002064_seizures	3.48094800
7	MP0002063_abnormal_learning/memory/cond	3.30165819
8	MP0009745_abnormal_behavioral_response	3.26510465
9	MP0002272_abnormal_nervous_system	3.04278879
10	MP0002734_abnormal_mechanical_nocicepti	2.92606394
11	MP0001486_abnormal_startle_reflex	2.91026497
12	MP0001968_abnormal_touch/_nociception	2.88803410
13	MP0002572_abnormal_emotion/affect_behav	2.69542962
14	MP0003879_abnormal_hair_cell	2.57672146
15	MP0009046_muscle_twitch	2.47783096
16	MP0003329_amyloid_beta_deposits	2.36244637
17	MP0002736_abnormal_nociception_after	2.28784680
18	MP0002735_abnormal_chemical_nociception	2.24026600
19	MP0001970_abnormal_pain_threshold	2.15837501
20	MP0002733_abnormal_thermal_nociception	2.11940680
21	MP0008569_lethality_at_weaning	2.06512252
22	MP0000778_abnormal_nervous_system	2.02132366
23	MP0001440_abnormal_grooming_behavior	1.98606280
24	MP0006276_abnormal_autonomic_nervous	1.97584469
25	MP0001501_abnormal_sleep_pattern	1.96484283
26	MP0004885_abnormal_endolymph	1.84578512
27	MP0003122_maternal_imprinting	1.83126869
28	MP0004811_abnormal_neuron_physiology	1.82947749
29	MP0002557_abnormal_social/conspecific_i	1.76586716
30	MP0001502_abnormal_circadian_rhythm	1.76270396
31	MP0001984_abnormal_olfaction	1.75418461
32	MP0002067_abnormal_sensory_capabilities	1.71171706
33	MP0003787_abnormal_imprinting	1.68674671
34	MP0004742_abnormal_vestibular_system	1.63994445
35	MP0000955_abnormal_spinal_cord	1.57357392
36	MP0002882_abnormal_neuron_morphology	1.56187543
37	MP0002066_abnormal_motor_capabilities/c	1.49241743
38	MP0003633_abnormal_nervous_system	1.46668118
39	MP0001905_abnormal_dopamine_level	1.43892571
40	MP0002822_catalepsy	1.40897175
41	MP0003690_abnormal_glial_cell	1.39895197
42	MP0001529_abnormal_vocalization	1.36096105
43	MP0009780_abnormal_chondrocyte_physiolo	1.34483809
44	MP0004924_abnormal_behavior	1.34169738
45	MP0005386_behavior/neurological_phenoty	1.34169738
46	MP0000920_abnormal_myelination	1.32672710
47	MP0002184_abnormal_innervation	1.32408235
48	MP0001177_atelectasis	1.27827809
49	MP0003631_nervous_system_phenotype	1.26235732
50	MP0005646_abnormal_pituitary_gland	1.25384065
51	MP0004142_abnormal_muscle_tone	1.20760771
52	MP0002152_abnormal_brain_morphology	1.20202022
53	MP0002638_abnormal_pupillary_reflex	1.14918898
54	MP0001963_abnormal_hearing_physiology	1.13699702
55	MP0001986_abnormal_taste_sensitivity	1.12710569
56	MP0003123_paternal_imprinting	1.08785057
57	MP0000604_amyloidosis	1.06909882
58	MP0003634_abnormal_glial_cell	1.06314086
59	MP0002229_neurodegeneration	1.05936795
60	MP0004858_abnormal_nervous_system	1.03040366
61	MP0001485_abnormal_pinna_reflex	1.00459296
62	MP0002653_abnormal_ependyma_morphology	0.99807977
63	MP0003075_altered_response_to	0.98639680
64	MP0003632_abnormal_nervous_system	0.94488380
65	MP0005551_abnormal_eye_electrophysiolog	0.90709000
66	MP0003121_genomic_imprinting	0.88953567
67	MP0002069_abnormal_eating/drinking_beha	0.85218234
68	MP0001188_hyperpigmentation	0.84944918
69	MP0002752_abnormal_somatic_nervous	0.84607208
70	MP0000026_abnormal_inner_ear	0.81206917
71	MP0005167_abnormal_blood-brain_barrier	0.79600927
72	MP0010386_abnormal_urinary_bladder	0.74767080
73	MP0008874_decreased_physiological_sensi	0.74051209
74	MP0008877_abnormal_DNA_methylation	0.71872495
75	MP0003861_abnormal_nervous_system	0.70621505
76	MP0001346_abnormal_lacrimal_gland	0.70102744
77	MP0005645_abnormal_hypothalamus_physiol	0.68749612
78	MP0004130_abnormal_muscle_cell	0.68084883
79	MP0005623_abnormal_meninges_morphology	0.65419604
80	MP0001348_abnormal_lacrimal_gland	0.64676175
81	MP0003136_yellow_coat_color	0.63725928
82	MP0005394_taste/olfaction_phenotype	0.63221360
83	MP0005499_abnormal_olfactory_system	0.63221360
84	MP0001943_abnormal_respiration	0.60195522
85	MP0002909_abnormal_adrenal_gland	0.58893462
86	MP0000631_abnormal_neuroendocrine_gland	0.57727416
87	MP0003137_abnormal_impulse_conducting	0.57227669
88	MP0010769_abnormal_survival	0.55478083
89	MP0005535_abnormal_body_temperature	0.55405637
90	MP0003172_abnormal_lysosome_physiology	0.54371682
91	MP0008872_abnormal_physiological_respon	0.53219184
92	MP0010768_mortality/aging	0.52131044
93	MP0002090_abnormal_vision	0.51959776
94	MP0002082_postnatal_lethality	0.51936888
95	MP0010770_preweaning_lethality	0.51936888
96	MP0002081_perinatal_lethality	0.50778046
97	MP0004133_heterotaxia	0.50368075
98	MP0003183_abnormal_peptide_metabolism	0.49973681
99	MP0002249_abnormal_larynx_morphology	0.49648435
100	MP0003956_abnormal_body_size	0.49563324

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myokymia (HP:0002411)	7.98825357
2	Focal motor seizures (HP:0011153)	6.63608133
3	Focal seizures (HP:0007359)	5.99361700
4	Epileptic encephalopathy (HP:0200134)	5.07580166
5	Action tremor (HP:0002345)	5.00685823
6	Febrile seizures (HP:0002373)	4.95676773
7	Atonic seizures (HP:0010819)	4.88528535
8	Ankle clonus (HP:0011448)	4.54259765
9	Abnormal eating behavior (HP:0100738)	4.42861527
10	Diplopia (HP:0000651)	4.41986268
11	Abnormality of binocular vision (HP:0011514)	4.41986268
12	Supranuclear gaze palsy (HP:0000605)	4.38613475
13	Generalized tonic-clonic seizures (HP:0002069)	4.10539352
14	Neurofibrillary tangles (HP:0002185)	4.05617993
15	Visual hallucinations (HP:0002367)	4.05184217
16	Polyphagia (HP:0002591)	4.01024799
17	Progressive cerebellar ataxia (HP:0002073)	3.87379130
18	Absence seizures (HP:0002121)	3.80873936
19	Spastic gait (HP:0002064)	3.72506758
20	Urinary bladder sphincter dysfunction (HP:0002839)	3.59351791
21	Dialeptic seizures (HP:0011146)	3.50886295
22	Impaired vibration sensation in the lower limbs (HP:0002166)	3.41455243
23	Urinary urgency (HP:0000012)	3.27381624
24	Limb dystonia (HP:0002451)	3.26483614
25	Mutism (HP:0002300)	3.25436510
26	Cerebral inclusion bodies (HP:0100314)	3.13318925
27	Cerebral hypomyelination (HP:0006808)	3.12407728
28	Annular pancreas (HP:0001734)	3.11986526
29	Intention tremor (HP:0002080)	3.10015556
30	Failure to thrive in infancy (HP:0001531)	3.08864173
31	Dysmetria (HP:0001310)	3.08056691
32	Status epilepticus (HP:0002133)	3.06503079
33	Peripheral hypomyelination (HP:0007182)	3.04793549
34	Postural instability (HP:0002172)	3.03997719
35	Sleep apnea (HP:0010535)	3.03493643
36	Papilledema (HP:0001085)	3.01518682
37	Delusions (HP:0000746)	2.99105352
38	Epileptiform EEG discharges (HP:0011182)	2.93499136
39	Torticollis (HP:0000473)	2.91100066
40	Hemiplegia (HP:0002301)	2.90194192
41	Truncal ataxia (HP:0002078)	2.83222074
42	Neuronal loss in central nervous system (HP:0002529)	2.80107771
43	Akinesia (HP:0002304)	2.79766584
44	Amblyopia (HP:0000646)	2.75288223
45	Poor eye contact (HP:0000817)	2.75029367
46	Hemiparesis (HP:0001269)	2.74821813
47	Obstructive sleep apnea (HP:0002870)	2.74255496
48	Depression (HP:0000716)	2.69879477
49	Clonus (HP:0002169)	2.69768142
50	Abnormality of the corticospinal tract (HP:0002492)	2.65564325
51	EEG with generalized epileptiform discharges (HP:0011198)	2.65198357
52	Poor suck (HP:0002033)	2.56696647
53	Focal dystonia (HP:0004373)	2.53119631
54	Lower limb muscle weakness (HP:0007340)	2.51269485
55	Hypsarrhythmia (HP:0002521)	2.48600568
56	Bradykinesia (HP:0002067)	2.45821409
57	Dysdiadochokinesis (HP:0002075)	2.45213142
58	Tetraplegia (HP:0002445)	2.42327026
59	Insomnia (HP:0100785)	2.40541263
60	Megalencephaly (HP:0001355)	2.40174050
61	Anxiety (HP:0000739)	2.38378108
62	Impaired social interactions (HP:0000735)	2.37783090
63	Abnormal social behavior (HP:0012433)	2.37783090
64	CNS hypomyelination (HP:0003429)	2.35828420
65	Gait imbalance (HP:0002141)	2.35094725
66	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.28023888
67	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.28023888
68	Apathy (HP:0000741)	2.24924195
69	Impaired vibratory sensation (HP:0002495)	2.23145597
70	Diminished motivation (HP:0000745)	2.22938919
71	Drooling (HP:0002307)	2.22260331
72	Craniofacial dystonia (HP:0012179)	2.21026812
73	Morphological abnormality of the pyramidal tract (HP:0002062)	2.17981982
74	Impaired smooth pursuit (HP:0007772)	2.16303569
75	Spastic tetraparesis (HP:0001285)	2.14480057
76	Morphological abnormality of the inner ear (HP:0011390)	2.13820179
77	Split foot (HP:0001839)	2.09772473
78	Excessive salivation (HP:0003781)	2.03418703
79	Specific learning disability (HP:0001328)	2.00112856
80	Rigidity (HP:0002063)	1.99628961
81	Anomalous pulmonary venous return (HP:0010772)	1.95884894
82	Incomplete penetrance (HP:0003829)	1.92367940
83	Hypoplasia of the corpus callosum (HP:0002079)	1.92171901
84	Abnormality of cochlea (HP:0000375)	1.91633568
85	Stereotypic behavior (HP:0000733)	1.90045221
86	Aplasia involving bones of the upper limbs (HP:0009823)	1.87515623
87	Aplasia of the phalanges of the hand (HP:0009802)	1.87515623
88	Aplasia involving bones of the extremities (HP:0009825)	1.87515623
89	Amyotrophic lateral sclerosis (HP:0007354)	1.87170873
90	Choreoathetosis (HP:0001266)	1.86623271
91	Broad-based gait (HP:0002136)	1.84214403
92	Abnormality of the lower motor neuron (HP:0002366)	1.83492818
93	Increased circulating renin level (HP:0000848)	1.82816527
94	Rapidly progressive (HP:0003678)	1.79514129
95	Genetic anticipation (HP:0003743)	1.76990622
96	Abnormality of the labia minora (HP:0012880)	1.73577351
97	Spastic tetraplegia (HP:0002510)	1.71793788
98	Absent speech (HP:0001344)	1.70254754
99	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.69760226
100	Abnormality of ocular smooth pursuit (HP:0000617)	1.69611027

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA4	5.54563053
2	NTRK3	4.15861269
3	MARK1	4.15183831
4	PAK6	3.66223030
5	PRKD3	3.33261096
6	DAPK2	3.30756091
7	SIK2	2.87407156
8	NTRK2	2.54824016
9	UHMK1	2.35767592
10	CAMKK1	2.33720743
11	CASK	2.23719229
12	MAP3K9	2.17477924
13	MINK1	2.15328574
14	CDK19	1.95199915
15	MAPK13	1.88854196
16	NTRK1	1.82260860
17	ARAF	1.66147527
18	GRK5	1.64565803
19	PLK2	1.64344721
20	PINK1	1.61449564
21	CDK5	1.56999241
22	TYRO3	1.45051762
23	PHKG1	1.40744679
24	PHKG2	1.40744679
25	DAPK1	1.36794234
26	PRKCG	1.34375494
27	CAMK1	1.33715447
28	RIPK4	1.24037072
29	SGK494	1.17830967
30	SGK223	1.17830967
31	CDK15	1.15516937
32	CAMK2B	1.15363184
33	DYRK1A	1.15122281
34	PRKCH	1.14225826
35	NEK6	1.13613432
36	CDK18	1.12183790
37	MARK2	1.11782283
38	CDK11A	1.09080637
39	CDK14	1.07861357
40	PAK3	1.06838133
41	MAPK12	0.94593895
42	MAP2K7	0.93279634
43	LATS2	0.93071029
44	CAMK2A	0.90651016
45	PKN1	0.89880607
46	STK11	0.89668462
47	STK38	0.88577801
48	MAP3K4	0.86191607
49	KSR2	0.85329978
50	CSNK1G2	0.84424564
51	CAMK2G	0.83587913
52	SGK3	0.82660864
53	RIPK1	0.79905987
54	BRSK1	0.79531683
55	TSSK6	0.77634604
56	CAMKK2	0.77250311
57	SGK2	0.76938618
58	DYRK2	0.75865892
59	ALK	0.70440547
60	PRKCZ	0.69388946
61	CAMK4	0.68678606
62	DAPK3	0.66606786
63	MAPKAPK5	0.61566843
64	BRAF	0.61248945
65	TNK2	0.60726261
66	MAPK10	0.59780294
67	SGK1	0.57936955
68	PDK1	0.57736814
69	BMPR2	0.56296907
70	LIMK1	0.55921462
71	CSNK1G3	0.54336462
72	IRAK2	0.52098880
73	CSNK1A1L	0.51965077
74	MAP2K4	0.50110781
75	RPS6KA3	0.49377730
76	PRPF4B	0.49284669
77	MAP3K11	0.48585049
78	OXSR1	0.46449084
79	TESK1	0.45451977
80	PDPK1	0.45128789
81	LMTK2	0.42690427
82	CAMK2D	0.41872408
83	CAMK1D	0.40965885
84	RPS6KA2	0.40258868
85	ICK	0.39737644
86	ROCK2	0.36645815
87	DYRK1B	0.36009682
88	KSR1	0.34248538
89	FYN	0.33709117
90	CAMK1G	0.32721727
91	FES	0.32475833
92	PRKCA	0.31564482
93	RAF1	0.30827271
94	CSNK1D	0.30561998
95	CSNK1G1	0.29006286
96	CCNB1	0.28941951
97	PRKACA	0.28454202
98	MAPK8	0.28044759
99	MAPK15	0.27860118
100	FGFR2	0.26409181

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.38885282
2	Synaptic vesicle cycle_Homo sapiens_hsa04721	3.98736127
3	GABAergic synapse_Homo sapiens_hsa04727	3.04130240
4	Morphine addiction_Homo sapiens_hsa05032	2.78526800
5	Circadian entrainment_Homo sapiens_hsa04713	2.78487306
6	Glutamatergic synapse_Homo sapiens_hsa04724	2.73633484
7	Amphetamine addiction_Homo sapiens_hsa05031	2.73260430
8	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.70361043
9	Long-term potentiation_Homo sapiens_hsa04720	2.66716669
10	Insulin secretion_Homo sapiens_hsa04911	2.56577209
11	Dopaminergic synapse_Homo sapiens_hsa04728	2.26457086
12	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.24558345
13	Cocaine addiction_Homo sapiens_hsa05030	2.20973878
14	Gastric acid secretion_Homo sapiens_hsa04971	2.08767935
15	Cholinergic synapse_Homo sapiens_hsa04725	2.06584847
16	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	2.01242229
17	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.98605298
18	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.97075311
19	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.82891429
20	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.73815765
21	Salivary secretion_Homo sapiens_hsa04970	1.63931828
22	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.59977832
23	Calcium signaling pathway_Homo sapiens_hsa04020	1.44776465
24	cAMP signaling pathway_Homo sapiens_hsa04024	1.39478597
25	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.39323677
26	Taste transduction_Homo sapiens_hsa04742	1.36860938
27	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.33995365
28	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.29796440
29	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.28226757
30	Estrogen signaling pathway_Homo sapiens_hsa04915	1.24437740
31	Olfactory transduction_Homo sapiens_hsa04740	1.23822723
32	Long-term depression_Homo sapiens_hsa04730	1.22809685
33	Glioma_Homo sapiens_hsa05214	1.21072313
34	Renin secretion_Homo sapiens_hsa04924	1.20149146
35	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.17393604
36	GnRH signaling pathway_Homo sapiens_hsa04912	1.14466022
37	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.14035851
38	Serotonergic synapse_Homo sapiens_hsa04726	1.13287455
39	Axon guidance_Homo sapiens_hsa04360	1.10341332
40	Collecting duct acid secretion_Homo sapiens_hsa04966	1.09676156
41	Melanogenesis_Homo sapiens_hsa04916	1.08054599
42	Cardiac muscle contraction_Homo sapiens_hsa04260	1.03490251
43	Gap junction_Homo sapiens_hsa04540	1.02786916
44	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.02229660
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.01840117
46	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.95658333
47	ErbB signaling pathway_Homo sapiens_hsa04012	0.94486358
48	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.89471567
49	Oocyte meiosis_Homo sapiens_hsa04114	0.80676630
50	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.80041964
51	Vibrio cholerae infection_Homo sapiens_hsa05110	0.78147184
52	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.78038609
53	Pancreatic secretion_Homo sapiens_hsa04972	0.76136462
54	Phototransduction_Homo sapiens_hsa04744	0.75560605
55	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.73728275
56	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.72910064
57	Prion diseases_Homo sapiens_hsa05020	0.72316740
58	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.71320714
59	VEGF signaling pathway_Homo sapiens_hsa04370	0.68036093
60	Sulfur relay system_Homo sapiens_hsa04122	0.67716663
61	Bile secretion_Homo sapiens_hsa04976	0.65588917
62	Alcoholism_Homo sapiens_hsa05034	0.63790848
63	MAPK signaling pathway_Homo sapiens_hsa04010	0.62964049
64	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.58039947
65	Type II diabetes mellitus_Homo sapiens_hsa04930	0.57684242
66	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.57224718
67	Arginine and proline metabolism_Homo sapiens_hsa00330	0.56725922
68	Rap1 signaling pathway_Homo sapiens_hsa04015	0.55924683
69	Ras signaling pathway_Homo sapiens_hsa04014	0.53604104
70	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.51861635
71	Alzheimers disease_Homo sapiens_hsa05010	0.51593547
72	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.51345312
73	Endocytosis_Homo sapiens_hsa04144	0.50930890
74	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.49973111
75	Choline metabolism in cancer_Homo sapiens_hsa05231	0.48787591
76	Glucagon signaling pathway_Homo sapiens_hsa04922	0.47184272
77	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.46200628
78	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.43522158
79	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.39572326
80	AMPK signaling pathway_Homo sapiens_hsa04152	0.38500693
81	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.37532893
82	mTOR signaling pathway_Homo sapiens_hsa04150	0.37487310
83	Wnt signaling pathway_Homo sapiens_hsa04310	0.37444657
84	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.34715394
85	Butanoate metabolism_Homo sapiens_hsa00650	0.32986902
86	Arginine biosynthesis_Homo sapiens_hsa00220	0.31466974
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.28659674
88	Hippo signaling pathway_Homo sapiens_hsa04390	0.27712228
89	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.27565922
90	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.26872025
91	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.26164540
92	Circadian rhythm_Homo sapiens_hsa04710	0.26094390
93	Insulin signaling pathway_Homo sapiens_hsa04910	0.25553470
94	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.23895548
95	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.23863577
96	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.21909956
97	Steroid biosynthesis_Homo sapiens_hsa00100	0.21551345
98	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.21501714
99	Endometrial cancer_Homo sapiens_hsa05213	0.19380814
100	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.19351108

LINC00634

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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