ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.43452842
2	regulation of hexokinase activity (GO:1903299)	5.06760435
3	regulation of glucokinase activity (GO:0033131)	5.06760435
4	startle response (GO:0001964)	4.49413228
5	presynaptic membrane assembly (GO:0097105)	4.22328891
6	innervation (GO:0060384)	3.99234243
7	cellular ketone body metabolic process (GO:0046950)	3.93439583
8	auditory behavior (GO:0031223)	3.80045492
9	inositol phosphate catabolic process (GO:0071545)	3.67486109
10	cochlea development (GO:0090102)	3.66701341
11	water-soluble vitamin biosynthetic process (GO:0042364)	3.58677661
12	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.56487698
13	intraciliary transport (GO:0042073)	3.52560197
14	dendritic spine morphogenesis (GO:0060997)	3.52488358
15	protein localization to cilium (GO:0061512)	3.52420134
16	presynaptic membrane organization (GO:0097090)	3.51129763
17	ketone body metabolic process (GO:1902224)	3.48432485
18	negative regulation of protein oligomerization (GO:0032460)	3.43678397
19	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.43070049
20	nonmotile primary cilium assembly (GO:0035058)	3.41453025
21	reflex (GO:0060004)	3.39442537
22	glycerophospholipid catabolic process (GO:0046475)	3.32027267
23	positive regulation of glycolytic process (GO:0045821)	3.31236601
24	behavioral response to nicotine (GO:0035095)	3.22697476
25	negative regulation of dendrite development (GO:2000171)	3.17956475
26	epithelial cilium movement (GO:0003351)	3.12861771
27	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.12727750
28	endocrine pancreas development (GO:0031018)	3.08197245
29	mechanosensory behavior (GO:0007638)	3.07791214
30	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.04241367
31	inositol phosphate dephosphorylation (GO:0046855)	3.04241367
32	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.00172949
33	L-fucose catabolic process (GO:0042355)	2.98680217
34	fucose catabolic process (GO:0019317)	2.98680217
35	L-fucose metabolic process (GO:0042354)	2.98680217
36	neural tube formation (GO:0001841)	2.97083359
37	insulin secretion (GO:0030073)	2.96850016
38	regulation of cilium movement (GO:0003352)	2.95973158
39	neuronal action potential (GO:0019228)	2.94496484
40	brain morphogenesis (GO:0048854)	2.93620508
41	pyrimidine nucleobase catabolic process (GO:0006208)	2.93085272
42	neuron cell-cell adhesion (GO:0007158)	2.91172754
43	polyol catabolic process (GO:0046174)	2.90675343
44	respiratory chain complex IV assembly (GO:0008535)	2.89978593
45	cilium movement (GO:0003341)	2.89638405
46	response to auditory stimulus (GO:0010996)	2.89534825
47	nucleobase catabolic process (GO:0046113)	2.89359619
48	adult feeding behavior (GO:0008343)	2.88742427
49	cilium organization (GO:0044782)	2.88012808
50	proline transport (GO:0015824)	2.87271830
51	positive regulation of insulin secretion (GO:0032024)	2.86868013
52	cilium assembly (GO:0042384)	2.86779713
53	dentate gyrus development (GO:0021542)	2.82985891
54	photoreceptor cell maintenance (GO:0045494)	2.78725485
55	toxin metabolic process (GO:0009404)	2.78103856
56	cilium morphogenesis (GO:0060271)	2.77885545
57	positive regulation of peptide hormone secretion (GO:0090277)	2.76177848
58	negative regulation of neurological system process (GO:0031645)	2.71170348
59	spinal cord motor neuron differentiation (GO:0021522)	2.70479835
60	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.70292448
61	axoneme assembly (GO:0035082)	2.69558506
62	cornea development in camera-type eye (GO:0061303)	2.67881106
63	positive regulation of peptide secretion (GO:0002793)	2.66380934
64	detection of calcium ion (GO:0005513)	2.65234206
65	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.64454478
66	inner ear receptor cell development (GO:0060119)	2.63040213
67	synapse assembly (GO:0007416)	2.62436267
68	kidney morphogenesis (GO:0060993)	2.60512991
69	protein prenylation (GO:0018342)	2.58780888
70	prenylation (GO:0097354)	2.58780888
71	postsynaptic membrane organization (GO:0001941)	2.58100496
72	retinal ganglion cell axon guidance (GO:0031290)	2.57899524
73	regulation of collateral sprouting (GO:0048670)	2.56696747
74	regulation of telomere maintenance (GO:0032204)	2.55549699
75	neuron fate determination (GO:0048664)	2.53396195
76	establishment of protein localization to Golgi (GO:0072600)	2.53197979
77	protein localization to Golgi apparatus (GO:0034067)	2.52860901
78	smoothened signaling pathway (GO:0007224)	2.52305423
79	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.50588335
80	nitric oxide mediated signal transduction (GO:0007263)	2.49961696
81	synaptic vesicle maturation (GO:0016188)	2.49650023
82	keratinocyte development (GO:0003334)	2.49647789
83	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.48846963
84	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.46550003
85	calcium ion import (GO:0070509)	2.43628381
86	protein targeting to Golgi (GO:0000042)	2.43494794
87	axonemal dynein complex assembly (GO:0070286)	2.43043765
88	righting reflex (GO:0060013)	2.42808319
89	regulation of microtubule-based movement (GO:0060632)	2.41799150
90	S-adenosylmethionine metabolic process (GO:0046500)	2.40092499
91	cranial nerve development (GO:0021545)	2.39080605
92	acrosome reaction (GO:0007340)	2.37959836
93	alanine transport (GO:0032328)	2.37952102
94	cytochrome complex assembly (GO:0017004)	2.36761877
95	detection of light stimulus involved in visual perception (GO:0050908)	2.36046924
96	detection of light stimulus involved in sensory perception (GO:0050962)	2.36046924
97	central nervous system neuron axonogenesis (GO:0021955)	2.35845212
98	behavioral response to ethanol (GO:0048149)	2.32906058
99	membrane depolarization during action potential (GO:0086010)	2.32879877
100	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.32646182

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.32345695
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.24151693
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.13490278
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.92036443
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.80462231
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.75965991
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.66830462
8	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.62438362
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.46530805
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.40837345
11	VDR_22108803_ChIP-Seq_LS180_Human	2.29596189
12	P300_19829295_ChIP-Seq_ESCs_Human	2.06939993
13	FUS_26573619_Chip-Seq_HEK293_Human	2.05829624
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02967928
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.87055502
16	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.82367009
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.82216621
18	TAF15_26573619_Chip-Seq_HEK293_Human	1.81967005
19	EZH2_22144423_ChIP-Seq_EOC_Human	1.78402510
20	SMAD4_21799915_ChIP-Seq_A2780_Human	1.77636235
21	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.75457310
22	REST_21632747_ChIP-Seq_MESCs_Mouse	1.68748016
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.68394976
24	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.68013889
25	CBP_20019798_ChIP-Seq_JUKART_Human	1.66453387
26	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.66453387
27	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.63940487
28	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.62514860
29	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.62186790
30	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.61496331
31	EWS_26573619_Chip-Seq_HEK293_Human	1.60617535
32	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.60334093
33	AR_25329375_ChIP-Seq_VCAP_Human	1.58813454
34	STAT3_23295773_ChIP-Seq_U87_Human	1.58123603
35	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.57029656
36	RNF2_27304074_Chip-Seq_NSC_Mouse	1.55729859
37	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.55428313
38	ER_23166858_ChIP-Seq_MCF-7_Human	1.55240595
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53973357
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.52509897
41	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.50182858
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.49697122
43	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.49691781
44	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.48747372
45	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.46513498
46	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.46395853
47	TCF4_23295773_ChIP-Seq_U87_Human	1.42858660
48	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.42266654
49	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.35275338
50	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.35056899
51	RUNX2_22187159_ChIP-Seq_PCA_Human	1.32678357
52	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.31369821
53	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.31177104
54	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.28617410
55	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.28199533
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27682157
57	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27513738
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27411261
59	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.26934288
60	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26912306
61	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.26912306
62	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26758327
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.26228862
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.25844856
65	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.25218970
66	TP53_22573176_ChIP-Seq_HFKS_Human	1.24423502
67	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.22643709
68	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21759009
69	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.20156825
70	IRF1_19129219_ChIP-ChIP_H3396_Human	1.19985538
71	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.19665991
72	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19585298
73	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19585298
74	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16992348
75	HTT_18923047_ChIP-ChIP_STHdh_Human	1.16936804
76	P53_22387025_ChIP-Seq_ESCs_Mouse	1.16578361
77	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.15193333
78	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13966070
79	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13515161
80	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.10249409
81	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.09358020
82	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.08521602
83	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.07953979
84	NCOR_22424771_ChIP-Seq_293T_Human	1.07944963
85	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.07886164
86	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.07132821
87	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.06675872
88	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04363745
89	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04363745
90	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04124201
91	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.03886562
92	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03693829
93	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.02370551
94	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02187740
95	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.01884592
96	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01129894
97	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.01080328
98	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.01044531
99	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00831514
100	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.00008401

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.25056986
2	MP0003122_maternal_imprinting	3.19689972
3	MP0003787_abnormal_imprinting	3.17018572
4	MP0009046_muscle_twitch	3.13817085
5	MP0001984_abnormal_olfaction	2.71010843
6	MP0008877_abnormal_DNA_methylation	2.37196351
7	MP0002837_dystrophic_cardiac_calcinosis	2.34571680
8	MP0002909_abnormal_adrenal_gland	2.33813468
9	MP0006072_abnormal_retinal_apoptosis	2.33449759
10	MP0003195_calcinosis	2.32645066
11	MP0005645_abnormal_hypothalamus_physiol	2.16059079
12	MP0001968_abnormal_touch/_nociception	2.06896720
13	MP0009745_abnormal_behavioral_response	2.05387647
14	MP0003880_abnormal_central_pattern	2.00807525
15	MP0005551_abnormal_eye_electrophysiolog	1.92555807
16	MP0004270_analgesia	1.90669429
17	MP0002272_abnormal_nervous_system	1.90070419
18	MP0003283_abnormal_digestive_organ	1.89378691
19	MP0004885_abnormal_endolymph	1.88187545
20	MP0003121_genomic_imprinting	1.86666425
21	MP0002064_seizures	1.82866098
22	MP0002736_abnormal_nociception_after	1.81650694
23	MP0005253_abnormal_eye_physiology	1.80501889
24	MP0005379_endocrine/exocrine_gland_phen	1.77491569
25	MP0002876_abnormal_thyroid_physiology	1.77071732
26	MP0002653_abnormal_ependyma_morphology	1.74047153
27	MP0000569_abnormal_digit_pigmentation	1.73472349
28	MP0002734_abnormal_mechanical_nocicepti	1.72933920
29	MP0003011_delayed_dark_adaptation	1.71773912
30	MP0001529_abnormal_vocalization	1.67802073
31	MP0003635_abnormal_synaptic_transmissio	1.63436004
32	MP0002572_abnormal_emotion/affect_behav	1.61701965
33	MP0000631_abnormal_neuroendocrine_gland	1.56324231
34	MP0009780_abnormal_chondrocyte_physiolo	1.50628795
35	MP0001944_abnormal_pancreas_morphology	1.48501803
36	MP0001486_abnormal_startle_reflex	1.47001944
37	MP0002557_abnormal_social/conspecific_i	1.45648338
38	MP0002063_abnormal_learning/memory/cond	1.45599901
39	MP0002822_catalepsy	1.44982272
40	MP0004142_abnormal_muscle_tone	1.44199297
41	MP0004043_abnormal_pH_regulation	1.40955061
42	MP0002693_abnormal_pancreas_physiology	1.37602930
43	MP0005386_behavior/neurological_phenoty	1.37089562
44	MP0004924_abnormal_behavior	1.37089562
45	MP0000013_abnormal_adipose_tissue	1.37087579
46	MP0002163_abnormal_gland_morphology	1.36783998
47	MP0005220_abnormal_exocrine_pancreas	1.36010183
48	MP0002938_white_spotting	1.35915477
49	MP0005646_abnormal_pituitary_gland	1.35481093
50	MP0008872_abnormal_physiological_respon	1.34863863
51	MP0000778_abnormal_nervous_system	1.34272312
52	MP0006276_abnormal_autonomic_nervous	1.34041927
53	MP0000427_abnormal_hair_cycle	1.30784650
54	MP0001970_abnormal_pain_threshold	1.30027849
55	MP0004133_heterotaxia	1.28434891
56	MP0004859_abnormal_synaptic_plasticity	1.26383723
57	MP0002184_abnormal_innervation	1.25919501
58	MP0002067_abnormal_sensory_capabilities	1.24106985
59	MP0002735_abnormal_chemical_nociception	1.23890814
60	MP0001501_abnormal_sleep_pattern	1.23748138
61	MP0002638_abnormal_pupillary_reflex	1.20742556
62	MP0001485_abnormal_pinna_reflex	1.17266349
63	MP0002229_neurodegeneration	1.14769441
64	MP0001986_abnormal_taste_sensitivity	1.14617389
65	MP0002928_abnormal_bile_duct	1.14516006
66	MP0004147_increased_porphyrin_level	1.13975278
67	MP0010386_abnormal_urinary_bladder	1.13579411
68	MP0001188_hyperpigmentation	1.11004706
69	MP0010234_abnormal_vibrissa_follicle	1.09420210
70	MP0003633_abnormal_nervous_system	1.08141248
71	MP0006292_abnormal_olfactory_placode	1.06238857
72	MP0004742_abnormal_vestibular_system	1.05264122
73	MP0001764_abnormal_homeostasis	1.04769799
74	MP0002078_abnormal_glucose_homeostasis	1.03999388
75	MP0002234_abnormal_pharynx_morphology	1.01932926
76	MP0001905_abnormal_dopamine_level	1.00088934
77	MP0005448_abnormal_energy_balance	0.98926537
78	MP0005084_abnormal_gallbladder_morpholo	0.96890652
79	MP0002733_abnormal_thermal_nociception	0.95839105
80	MP0004811_abnormal_neuron_physiology	0.93062577
81	MP0004134_abnormal_chest_morphology	0.92437528
82	MP0008789_abnormal_olfactory_epithelium	0.91279756
83	MP0002882_abnormal_neuron_morphology	0.91135230
84	MP0001756_abnormal_urination	0.90807271
85	MP0002069_abnormal_eating/drinking_beha	0.90570939
86	MP0000955_abnormal_spinal_cord	0.89793278
87	MP0002090_abnormal_vision	0.88832779
88	MP0002751_abnormal_autonomic_nervous	0.88810802
89	MP0005167_abnormal_blood-brain_barrier	0.88500577
90	MP0000026_abnormal_inner_ear	0.86959062
91	MP0005394_taste/olfaction_phenotype	0.86050722
92	MP0005499_abnormal_olfactory_system	0.86050722
93	MP0002254_reproductive_system_inflammat	0.85196475
94	MP0002752_abnormal_somatic_nervous	0.84509515
95	MP0005535_abnormal_body_temperature	0.83990930
96	MP0005367_renal/urinary_system_phenotyp	0.83699962
97	MP0000516_abnormal_urinary_system	0.83699962
98	MP0008875_abnormal_xenobiotic_pharmacok	0.82026198
99	MP0001963_abnormal_hearing_physiology	0.80098975
100	MP0005423_abnormal_somatic_nervous	0.79241956

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	3.98345765
2	Hypoglycemic seizures (HP:0002173)	3.95220783
3	Pancreatic fibrosis (HP:0100732)	3.93849759
4	Pancreatic cysts (HP:0001737)	3.87093780
5	Hyperinsulinemic hypoglycemia (HP:0000825)	3.75862658
6	Medial flaring of the eyebrow (HP:0010747)	3.51165323
7	Abnormality of midbrain morphology (HP:0002418)	3.49859653
8	Molar tooth sign on MRI (HP:0002419)	3.49859653
9	Ketoacidosis (HP:0001993)	3.38577126
10	Hypoglycemic coma (HP:0001325)	3.37086842
11	Chronic hepatic failure (HP:0100626)	3.35218598
12	Gait imbalance (HP:0002141)	3.16237432
13	Nephronophthisis (HP:0000090)	3.11693880
14	Congenital primary aphakia (HP:0007707)	3.00256479
15	Hypsarrhythmia (HP:0002521)	2.94204942
16	Large for gestational age (HP:0001520)	2.93935635
17	EEG with generalized epileptiform discharges (HP:0011198)	2.93250118
18	Epileptiform EEG discharges (HP:0011182)	2.89961658
19	Cystic liver disease (HP:0006706)	2.88617091
20	Hypothermia (HP:0002045)	2.85906010
21	Hemiparesis (HP:0001269)	2.81589180
22	Occipital encephalocele (HP:0002085)	2.74025207
23	Abnormality of the renal cortex (HP:0011035)	2.71162322
24	Furrowed tongue (HP:0000221)	2.68881025
25	Nephrogenic diabetes insipidus (HP:0009806)	2.67994077
26	Abnormality of the renal medulla (HP:0100957)	2.65455868
27	Polyphagia (HP:0002591)	2.60047331
28	Hypomagnesemia (HP:0002917)	2.58577045
29	Polydipsia (HP:0001959)	2.53523100
30	Abnormal drinking behavior (HP:0030082)	2.53523100
31	Abnormality of the pancreatic islet cells (HP:0006476)	2.51743783
32	Abnormality of endocrine pancreas physiology (HP:0012093)	2.51743783
33	Hyperglycemia (HP:0003074)	2.48971489
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.48658735
35	Progressive inability to walk (HP:0002505)	2.47805797
36	Limb dystonia (HP:0002451)	2.46418948
37	Agitation (HP:0000713)	2.43892423
38	Abnormality of the labia minora (HP:0012880)	2.40712307
39	Muscular hypotonia of the trunk (HP:0008936)	2.40041228
40	Abnormality of the metopic suture (HP:0005556)	2.34277655
41	Postaxial foot polydactyly (HP:0001830)	2.34094486
42	Symptomatic seizures (HP:0011145)	2.33758272
43	Lipid accumulation in hepatocytes (HP:0006561)	2.32090401
44	Congenital hepatic fibrosis (HP:0002612)	2.31785577
45	Progressive macrocephaly (HP:0004481)	2.30384266
46	Increased hepatocellular lipid droplets (HP:0006565)	2.29886266
47	Ketosis (HP:0001946)	2.29551015
48	Febrile seizures (HP:0002373)	2.29488979
49	Male pseudohermaphroditism (HP:0000037)	2.26848459
50	Genital tract atresia (HP:0001827)	2.26056894
51	Abolished electroretinogram (ERG) (HP:0000550)	2.24564378
52	Dialeptic seizures (HP:0011146)	2.23574184
53	Epileptic encephalopathy (HP:0200134)	2.23388865
54	Focal seizures (HP:0007359)	2.22316966
55	Vaginal atresia (HP:0000148)	2.22259132
56	Inability to walk (HP:0002540)	2.17179372
57	Attenuation of retinal blood vessels (HP:0007843)	2.17163820
58	Prominent metopic ridge (HP:0005487)	2.15072441
59	Abnormal respiratory motile cilium morphology (HP:0005938)	2.13626007
60	Abnormal respiratory epithelium morphology (HP:0012253)	2.13626007
61	Congenital stationary night blindness (HP:0007642)	2.12235194
62	Postaxial hand polydactyly (HP:0001162)	2.10982278
63	Intestinal atresia (HP:0011100)	2.10378415
64	Hyperventilation (HP:0002883)	2.09133072
65	Late onset (HP:0003584)	2.06100682
66	Poor suck (HP:0002033)	2.05078211
67	Progressive cerebellar ataxia (HP:0002073)	2.02278733
68	Focal motor seizures (HP:0011153)	2.01195123
69	Anencephaly (HP:0002323)	2.00964707
70	Enlarged penis (HP:0000040)	1.99678565
71	Abnormal ciliary motility (HP:0012262)	1.98643401
72	Polyuria (HP:0000103)	1.98009594
73	Narrow forehead (HP:0000341)	1.97910189
74	Tubular atrophy (HP:0000092)	1.97452407
75	Sclerocornea (HP:0000647)	1.97117603
76	Amyotrophic lateral sclerosis (HP:0007354)	1.94782071
77	Poor coordination (HP:0002370)	1.94163463
78	Decreased circulating renin level (HP:0003351)	1.93489820
79	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.92847898
80	Mitochondrial inheritance (HP:0001427)	1.92661915
81	Genetic anticipation (HP:0003743)	1.91972824
82	Abnormal respiratory motile cilium physiology (HP:0012261)	1.90918007
83	Acute necrotizing encephalopathy (HP:0006965)	1.89830214
84	Specific learning disability (HP:0001328)	1.89364385
85	Delayed gross motor development (HP:0002194)	1.88717749
86	3-Methylglutaconic aciduria (HP:0003535)	1.88610726
87	Gaze-evoked nystagmus (HP:0000640)	1.87191181
88	Type II lissencephaly (HP:0007260)	1.84408059
89	Amblyopia (HP:0000646)	1.83544466
90	Abnormal sex determination (HP:0012244)	1.83286688
91	Sex reversal (HP:0012245)	1.83286688
92	Renal Fanconi syndrome (HP:0001994)	1.82760965
93	Broad-based gait (HP:0002136)	1.82321784
94	Absence seizures (HP:0002121)	1.81395811
95	Abnormality of magnesium homeostasis (HP:0004921)	1.78848001
96	Increased CSF lactate (HP:0002490)	1.76403538
97	Insulin-resistant diabetes mellitus (HP:0000831)	1.75960094
98	Increased corneal curvature (HP:0100692)	1.75634491
99	Keratoconus (HP:0000563)	1.75634491
100	Pancreatic islet-cell hyperplasia (HP:0004510)	1.74623891

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.22601682
2	WNK3	3.60988878
3	FGFR2	2.99258830
4	PINK1	2.90723193
5	MAP4K2	2.59761087
6	MAP3K4	2.17420720
7	NTRK3	2.11844085
8	ADRBK2	2.04522049
9	INSRR	2.03879686
10	MARK1	2.03873637
11	CASK	2.02467894
12	BMPR1B	1.97682444
13	MAPK13	1.85787254
14	DAPK2	1.80561911
15	GRK1	1.73187863
16	FER	1.68000365
17	BCR	1.66448003
18	MAP2K7	1.64512372
19	PHKG2	1.63230774
20	PHKG1	1.63230774
21	PAK3	1.55294650
22	EPHA4	1.50404467
23	TRIM28	1.39199449
24	PRKCE	1.28832251
25	CSNK1G1	1.23932301
26	CSNK1G2	1.17707282
27	PRKCG	1.16328897
28	WNK4	1.13666864
29	CAMKK2	1.13422931
30	TNIK	1.12567516
31	DYRK2	1.12046804
32	PNCK	1.11860734
33	CSNK1G3	1.11438859
34	PLK2	1.10855912
35	NUAK1	1.07901136
36	ACVR1B	1.07402959
37	BCKDK	1.06307225
38	UHMK1	1.02978051
39	AKT3	1.01699020
40	IRAK1	0.99683580
41	PTK2B	0.98817310
42	ERBB3	0.98230036
43	FES	0.96980590
44	TAOK3	0.96619856
45	NTRK2	0.95836300
46	STK38L	0.89680486
47	OXSR1	0.87599039
48	CSNK1A1L	0.87146162
49	CAMK1	0.83039720
50	MAPK15	0.81712514
51	LATS1	0.77475731
52	STK39	0.76317190
53	ZAK	0.74543453
54	PLK3	0.74144931
55	DYRK3	0.73238625
56	IRAK2	0.73227110
57	PASK	0.72167233
58	FGFR3	0.70667850
59	YES1	0.69664100
60	CAMK2A	0.67248713
61	STK11	0.65572267
62	MINK1	0.63290122
63	SGK494	0.60848780
64	SGK223	0.60848780
65	ADRBK1	0.59285934
66	SGK2	0.58505762
67	PRKAA1	0.55351937
68	PRKCZ	0.54527751
69	CDK5	0.54114881
70	TLK1	0.53451484
71	MAP2K6	0.53076565
72	CAMK2D	0.52861267
73	MAP3K2	0.52823363
74	CSNK1A1	0.51662751
75	STK3	0.50096569
76	CAMK2B	0.49768649
77	DYRK1A	0.49360692
78	VRK1	0.49085990
79	MST4	0.48551495
80	PRKACA	0.45016118
81	LIMK1	0.44775892
82	MAP3K9	0.43817960
83	CSNK1D	0.43741848
84	PIK3CA	0.43275237
85	SIK2	0.42423381
86	PRKG1	0.42309073
87	STK24	0.42191182
88	CDK3	0.41484560
89	EIF2AK3	0.39553310
90	PRKAA2	0.38441368
91	TIE1	0.38398131
92	PKN1	0.37808536
93	RPS6KA5	0.37794679
94	BRSK2	0.36871265
95	PRKCH	0.35932579
96	PRKACB	0.35654924
97	PRKCA	0.33394599
98	HIPK2	0.33133484
99	LMTK2	0.31849006
100	MAP2K4	0.31181673

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	4.98129587
2	Butanoate metabolism_Homo sapiens_hsa00650	3.42604962
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.16665076
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.04216524
5	Insulin secretion_Homo sapiens_hsa04911	2.58197435
6	Nicotine addiction_Homo sapiens_hsa05033	2.56628041
7	Protein export_Homo sapiens_hsa03060	2.43488031
8	GABAergic synapse_Homo sapiens_hsa04727	2.05489561
9	Oxidative phosphorylation_Homo sapiens_hsa00190	1.94438929
10	Phototransduction_Homo sapiens_hsa04744	1.94272713
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.85531117
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.84479444
13	Collecting duct acid secretion_Homo sapiens_hsa04966	1.70938749
14	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.67093424
15	Morphine addiction_Homo sapiens_hsa05032	1.57508517
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.52599075
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.51978582
18	Regulation of autophagy_Homo sapiens_hsa04140	1.48034993
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.45267549
20	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.43605317
21	Circadian entrainment_Homo sapiens_hsa04713	1.42528562
22	Taste transduction_Homo sapiens_hsa04742	1.37660984
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.37441501
24	Glutamatergic synapse_Homo sapiens_hsa04724	1.35310824
25	Propanoate metabolism_Homo sapiens_hsa00640	1.29533381
26	ABC transporters_Homo sapiens_hsa02010	1.29087410
27	Amphetamine addiction_Homo sapiens_hsa05031	1.27144254
28	Dopaminergic synapse_Homo sapiens_hsa04728	1.21978620
29	Serotonergic synapse_Homo sapiens_hsa04726	1.21030122
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.19344308
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.17990205
32	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.14913095
33	Peroxisome_Homo sapiens_hsa04146	1.14411055
34	Parkinsons disease_Homo sapiens_hsa05012	1.13248219
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.11957236
36	Linoleic acid metabolism_Homo sapiens_hsa00591	1.08381770
37	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.08186844
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.04007110
39	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.03442221
40	Type II diabetes mellitus_Homo sapiens_hsa04930	1.03382996
41	Cocaine addiction_Homo sapiens_hsa05030	1.03133305
42	Basal transcription factors_Homo sapiens_hsa03022	1.02503058
43	Olfactory transduction_Homo sapiens_hsa04740	1.02409128
44	Long-term depression_Homo sapiens_hsa04730	1.01101625
45	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.99707428
46	Nitrogen metabolism_Homo sapiens_hsa00910	0.98370797
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.96776245
48	Cardiac muscle contraction_Homo sapiens_hsa04260	0.96042704
49	Salivary secretion_Homo sapiens_hsa04970	0.92623842
50	beta-Alanine metabolism_Homo sapiens_hsa00410	0.90758188
51	Steroid biosynthesis_Homo sapiens_hsa00100	0.89752463
52	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.87940580
53	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.86979567
54	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.85820239
55	Circadian rhythm_Homo sapiens_hsa04710	0.84851691
56	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.84293910
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.83454158
58	Alzheimers disease_Homo sapiens_hsa05010	0.81553240
59	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.80282606
60	Renin secretion_Homo sapiens_hsa04924	0.78604930
61	Huntingtons disease_Homo sapiens_hsa05016	0.77222592
62	Caffeine metabolism_Homo sapiens_hsa00232	0.72335329
63	Type I diabetes mellitus_Homo sapiens_hsa04940	0.71861310
64	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.70972984
65	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.70769558
66	Mineral absorption_Homo sapiens_hsa04978	0.69577081
67	Sulfur metabolism_Homo sapiens_hsa00920	0.68742201
68	Fatty acid elongation_Homo sapiens_hsa00062	0.67922169
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67915742
70	Fatty acid metabolism_Homo sapiens_hsa01212	0.63243667
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63191858
72	Gastric acid secretion_Homo sapiens_hsa04971	0.62781408
73	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.62342113
74	Folate biosynthesis_Homo sapiens_hsa00790	0.61899147
75	Sphingolipid metabolism_Homo sapiens_hsa00600	0.61323780
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.60580520
77	Cholinergic synapse_Homo sapiens_hsa04725	0.56576043
78	cAMP signaling pathway_Homo sapiens_hsa04024	0.55977087
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55971002
80	Bile secretion_Homo sapiens_hsa04976	0.55178858
81	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.54835628
82	Metabolic pathways_Homo sapiens_hsa01100	0.53591538
83	RNA degradation_Homo sapiens_hsa03018	0.52185591
84	Vibrio cholerae infection_Homo sapiens_hsa05110	0.49888994
85	Pancreatic secretion_Homo sapiens_hsa04972	0.49344690
86	Retinol metabolism_Homo sapiens_hsa00830	0.49164992
87	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.48922551
88	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.48682286
89	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.48162768
90	Fatty acid degradation_Homo sapiens_hsa00071	0.46792402
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.46005409
92	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.45922958
93	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.44466960
94	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.41581125
95	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.38916832
96	Glycerolipid metabolism_Homo sapiens_hsa00561	0.38846480
97	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37251771
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36312466
99	Fanconi anemia pathway_Homo sapiens_hsa03460	0.36128818
100	AMPK signaling pathway_Homo sapiens_hsa04152	0.35898712

LINC00643

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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