ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.28763329
2	cilium or flagellum-dependent cell motility (GO:0001539)	3.97589139
3	presynaptic membrane assembly (GO:0097105)	3.90243621
4	serotonin metabolic process (GO:0042428)	3.89937557
5	primary amino compound metabolic process (GO:1901160)	3.88682845
6	hindbrain development (GO:0030902)	3.82878863
7	response to pheromone (GO:0019236)	3.79022998
8	protein localization to synapse (GO:0035418)	3.78553494
9	protein complex biogenesis (GO:0070271)	3.77368236
10	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.76893688
11	postsynaptic membrane organization (GO:0001941)	3.70076157
12	presynaptic membrane organization (GO:0097090)	3.63963518
13	gamma-aminobutyric acid transport (GO:0015812)	3.56079526
14	neuronal action potential (GO:0019228)	3.55659407
15	mitochondrial respiratory chain complex assembly (GO:0033108)	3.46640502
16	piRNA metabolic process (GO:0034587)	3.39151554
17	cytochrome complex assembly (GO:0017004)	3.37213517
18	neuronal action potential propagation (GO:0019227)	3.35711809
19	auditory behavior (GO:0031223)	3.35080819
20	neuron cell-cell adhesion (GO:0007158)	3.31291205
21	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.30740046
22	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.28125945
23	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.28125945
24	regulation of translation, ncRNA-mediated (GO:0045974)	3.28125945
25	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.28026782
26	cellular response to ATP (GO:0071318)	3.26297943
27	dendritic spine morphogenesis (GO:0060997)	3.20614395
28	transmission of nerve impulse (GO:0019226)	3.11886807
29	L-fucose catabolic process (GO:0042355)	3.07506029
30	fucose catabolic process (GO:0019317)	3.07506029
31	L-fucose metabolic process (GO:0042354)	3.07506029
32	detection of light stimulus involved in sensory perception (GO:0050962)	3.05140342
33	detection of light stimulus involved in visual perception (GO:0050908)	3.05140342
34	negative regulation of membrane potential (GO:0045837)	3.04769277
35	axonemal dynein complex assembly (GO:0070286)	3.04733978
36	detection of mechanical stimulus involved in sensory perception (GO:0050974)	3.02639262
37	epithelial cilium movement (GO:0003351)	3.01571692
38	startle response (GO:0001964)	3.00349293
39	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.99971775
40	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.99460541
41	vocalization behavior (GO:0071625)	2.98764908
42	platelet dense granule organization (GO:0060155)	2.96564553
43	indole-containing compound metabolic process (GO:0042430)	2.93054087
44	membrane depolarization during action potential (GO:0086010)	2.92461589
45	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.92372358
46	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.91275618
47	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.90920915
48	NADH dehydrogenase complex assembly (GO:0010257)	2.90920915
49	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.90920915
50	indolalkylamine metabolic process (GO:0006586)	2.88347898
51	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.88099363
52	reflex (GO:0060004)	2.83397448
53	protein polyglutamylation (GO:0018095)	2.81753690
54	synaptic vesicle maturation (GO:0016188)	2.80060835
55	synaptic transmission, glutamatergic (GO:0035249)	2.79266442
56	mechanosensory behavior (GO:0007638)	2.78985910
57	neural tube formation (GO:0001841)	2.76975062
58	glutamate receptor signaling pathway (GO:0007215)	2.73919086
59	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.73909131
60	nonmotile primary cilium assembly (GO:0035058)	2.72232660
61	secretory granule organization (GO:0033363)	2.71600677
62	seminiferous tubule development (GO:0072520)	2.70147211
63	retinal cone cell development (GO:0046549)	2.69478275
64	spinal cord development (GO:0021510)	2.67324660
65	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.66235034
66	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.65702474
67	proline transport (GO:0015824)	2.64513698
68	neuron-neuron synaptic transmission (GO:0007270)	2.64503121
69	water-soluble vitamin biosynthetic process (GO:0042364)	2.64394693
70	neurotransmitter-gated ion channel clustering (GO:0072578)	2.63548676
71	positive regulation of cAMP-mediated signaling (GO:0043950)	2.63338048
72	cAMP catabolic process (GO:0006198)	2.61204057
73	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	2.61144659
74	inner ear receptor stereocilium organization (GO:0060122)	2.59772862
75	central nervous system myelination (GO:0022010)	2.59746453
76	axon ensheathment in central nervous system (GO:0032291)	2.59746453
77	tachykinin receptor signaling pathway (GO:0007217)	2.59449370
78	regulation of cilium movement (GO:0003352)	2.58297892
79	negative regulation of telomere maintenance (GO:0032205)	2.57889975
80	neuromuscular synaptic transmission (GO:0007274)	2.55928308
81	pyrimidine nucleobase catabolic process (GO:0006208)	2.55803642
82	protein localization to cilium (GO:0061512)	2.55426113
83	positive regulation of synapse assembly (GO:0051965)	2.55007798
84	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.54754547
85	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.54001325
86	C4-dicarboxylate transport (GO:0015740)	2.51474952
87	respiratory chain complex IV assembly (GO:0008535)	2.49298804
88	action potential (GO:0001508)	2.47260222
89	indole-containing compound catabolic process (GO:0042436)	2.46522527
90	indolalkylamine catabolic process (GO:0046218)	2.46522527
91	tryptophan catabolic process (GO:0006569)	2.46522527
92	signal complex assembly (GO:0007172)	2.46162687
93	positive regulation of translational initiation (GO:0045948)	2.45943960
94	sulfation (GO:0051923)	2.45304286
95	chemosensory behavior (GO:0007635)	2.44774376
96	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.43126906
97	membrane depolarization (GO:0051899)	2.42989509
98	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.42827564
99	cilium movement (GO:0003341)	2.42817781
100	cyclic nucleotide catabolic process (GO:0009214)	2.42796744

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.19893359
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.30150624
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.14461018
4	VDR_22108803_ChIP-Seq_LS180_Human	3.02914463
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.89801766
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.66055704
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.32824933
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.18812816
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.14157092
10	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.10604362
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.05598216
12	REST_21632747_ChIP-Seq_MESCs_Mouse	2.01017973
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.00543473
14	P300_19829295_ChIP-Seq_ESCs_Human	1.98132857
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.96369167
16	IGF1R_20145208_ChIP-Seq_DFB_Human	1.93225045
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.88094754
18	FUS_26573619_Chip-Seq_HEK293_Human	1.84033786
19	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.80260116
20	EWS_26573619_Chip-Seq_HEK293_Human	1.78757288
21	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.76491507
22	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.76461988
23	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.73616342
24	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.67699444
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.66091832
26	RNF2_27304074_Chip-Seq_NSC_Mouse	1.65042609
27	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.63834856
28	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.62939124
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.62079693
30	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.60285446
31	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.59086155
32	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.59086155
33	AR_21572438_ChIP-Seq_LNCaP_Human	1.58022086
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.56008730
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55154131
36	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.54877054
37	SMAD4_21799915_ChIP-Seq_A2780_Human	1.53933645
38	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.53759365
39	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.53349464
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.50587126
41	TP53_16413492_ChIP-PET_HCT116_Human	1.50004555
42	STAT3_23295773_ChIP-Seq_U87_Human	1.49896396
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.47034874
44	AR_25329375_ChIP-Seq_VCAP_Human	1.45781258
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45540737
46	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.42316311
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41950658
48	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.41866429
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.39284310
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39284310
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.37103835
52	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.36680994
53	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.36466290
54	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.36413706
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35429961
56	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.35297394
57	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.34991598
58	BCAT_22108803_ChIP-Seq_LS180_Human	1.34924750
59	TCF4_23295773_ChIP-Seq_U87_Human	1.34775286
60	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.33432125
61	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.32994842
62	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.29236411
63	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.28595434
64	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.28416596
65	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.28079688
66	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.27641805
67	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.27453261
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27033836
69	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25177099
70	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.24593519
71	IRF1_19129219_ChIP-ChIP_H3396_Human	1.23252217
72	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.22915905
73	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.22798673
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22515766
75	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.21269107
76	DROSHA_22980978_ChIP-Seq_HELA_Human	1.20517664
77	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.19596510
78	TP53_22573176_ChIP-Seq_HFKS_Human	1.19097704
79	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18503514
80	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18503514
81	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.17761841
82	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.17761841
83	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.17121539
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.16298940
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.14789336
86	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.13092758
87	TCF4_22108803_ChIP-Seq_LS180_Human	1.11155605
88	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11002540
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09801269
90	NCOR_22424771_ChIP-Seq_293T_Human	1.09408341
91	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.08218970
92	MYC_18940864_ChIP-ChIP_HL60_Human	1.07575721
93	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.07367855
94	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.07273145
95	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06700461
96	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06281223
97	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.06208860
98	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06054844
99	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.04544265
100	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.04028629

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001968_abnormal_touch/_nociception	3.61699646
2	MP0001986_abnormal_taste_sensitivity	3.29538992
3	MP0003880_abnormal_central_pattern	3.20095923
4	MP0002736_abnormal_nociception_after	2.65484847
5	MP0009745_abnormal_behavioral_response	2.64061422
6	MP0003787_abnormal_imprinting	2.61164816
7	MP0009046_muscle_twitch	2.52248698
8	MP0003646_muscle_fatigue	2.50605858
9	MP0002735_abnormal_chemical_nociception	2.47804311
10	MP0002272_abnormal_nervous_system	2.40897984
11	MP0003635_abnormal_synaptic_transmissio	2.28503392
12	MP0001486_abnormal_startle_reflex	2.25630689
13	MP0008877_abnormal_DNA_methylation	2.23020933
14	MP0002064_seizures	2.19077756
15	MP0003195_calcinosis	2.11485414
16	MP0004859_abnormal_synaptic_plasticity	2.03598480
17	MP0001501_abnormal_sleep_pattern	2.00956484
18	MP0005551_abnormal_eye_electrophysiolog	1.98067344
19	MP0002572_abnormal_emotion/affect_behav	1.92872850
20	MP0006292_abnormal_olfactory_placode	1.91919883
21	MP0008872_abnormal_physiological_respon	1.90946216
22	MP0005423_abnormal_somatic_nervous	1.90481688
23	MP0002734_abnormal_mechanical_nocicepti	1.89870957
24	MP0002063_abnormal_learning/memory/cond	1.88557157
25	MP0004885_abnormal_endolymph	1.85605196
26	MP0002102_abnormal_ear_morphology	1.83089819
27	MP0005646_abnormal_pituitary_gland	1.78325763
28	MP0004133_heterotaxia	1.75554408
29	MP0002837_dystrophic_cardiac_calcinosis	1.72653498
30	MP0002733_abnormal_thermal_nociception	1.72583660
31	MP0001970_abnormal_pain_threshold	1.72366768
32	MP0000569_abnormal_digit_pigmentation	1.71319690
33	MP0002557_abnormal_social/conspecific_i	1.69999238
34	MP0004742_abnormal_vestibular_system	1.63452711
35	MP0005386_behavior/neurological_phenoty	1.62549816
36	MP0004924_abnormal_behavior	1.62549816
37	MP0003136_yellow_coat_color	1.59035323
38	MP0006276_abnormal_autonomic_nervous	1.58536403
39	MP0002067_abnormal_sensory_capabilities	1.57764473
40	MP0002938_white_spotting	1.56814389
41	MP0001485_abnormal_pinna_reflex	1.54656731
42	MP0004142_abnormal_muscle_tone	1.49591709
43	MP0004147_increased_porphyrin_level	1.48200820
44	MP0003283_abnormal_digestive_organ	1.46511868
45	MP0003122_maternal_imprinting	1.43738139
46	MP0003121_genomic_imprinting	1.41581420
47	MP0004145_abnormal_muscle_electrophysio	1.40661133
48	MP0006072_abnormal_retinal_apoptosis	1.39776482
49	MP0005253_abnormal_eye_physiology	1.33621188
50	MP0002638_abnormal_pupillary_reflex	1.33016703
51	MP0001440_abnormal_grooming_behavior	1.32798674
52	MP0004270_analgesia	1.32696772
53	MP0005187_abnormal_penis_morphology	1.32124872
54	MP0001984_abnormal_olfaction	1.30906808
55	MP0000631_abnormal_neuroendocrine_gland	1.30142105
56	MP0003011_delayed_dark_adaptation	1.27667893
57	MP0000778_abnormal_nervous_system	1.26486640
58	MP0002876_abnormal_thyroid_physiology	1.26224654
59	MP0001905_abnormal_dopamine_level	1.24912775
60	MP0002277_abnormal_respiratory_mucosa	1.21131590
61	MP0000427_abnormal_hair_cycle	1.19713435
62	MP0000372_irregular_coat_pigmentation	1.17850894
63	MP0010386_abnormal_urinary_bladder	1.17656357
64	MP0005645_abnormal_hypothalamus_physiol	1.17590998
65	MP0003119_abnormal_digestive_system	1.11232461
66	MP0005389_reproductive_system_phenotype	1.04820732
67	MP0002928_abnormal_bile_duct	1.04448840
68	MP0001529_abnormal_vocalization	1.01961641
69	MP0005174_abnormal_tail_pigmentation	0.99958766
70	MP0003633_abnormal_nervous_system	0.99914902
71	MP0001919_abnormal_reproductive_system	0.97326902
72	MP0008875_abnormal_xenobiotic_pharmacok	0.96340939
73	MP0002184_abnormal_innervation	0.96071981
74	MP0002234_abnormal_pharynx_morphology	0.94022562
75	MP0002653_abnormal_ependyma_morphology	0.91967919
76	MP0001963_abnormal_hearing_physiology	0.91547974
77	MP0002882_abnormal_neuron_morphology	0.91425857
78	MP0000026_abnormal_inner_ear	0.90176774
79	MP0001502_abnormal_circadian_rhythm	0.90094586
80	MP0002752_abnormal_somatic_nervous	0.89735963
81	MP0000955_abnormal_spinal_cord	0.89243689
82	MP0005084_abnormal_gallbladder_morpholo	0.89233431
83	MP0002909_abnormal_adrenal_gland	0.86768043
84	MP0008995_early_reproductive_senescence	0.84507759
85	MP0002160_abnormal_reproductive_system	0.83652436
86	MP0001664_abnormal_digestion	0.81144764
87	MP0003890_abnormal_embryonic-extraembry	0.80978464
88	MP0002066_abnormal_motor_capabilities/c	0.80228091
89	MP0002229_neurodegeneration	0.78185708
90	MP0005410_abnormal_fertilization	0.75279956
91	MP0008569_lethality_at_weaning	0.73274293
92	MP0005195_abnormal_posterior_eye	0.72899365
93	MP0004215_abnormal_myocardial_fiber	0.72684372
94	MP0002751_abnormal_autonomic_nervous	0.72375942
95	MP0008775_abnormal_heart_ventricle	0.70882830
96	MP0000230_abnormal_systemic_arterial	0.70621835
97	MP0002069_abnormal_eating/drinking_beha	0.70512608
98	MP0004043_abnormal_pH_regulation	0.69019455
99	MP0003698_abnormal_male_reproductive	0.68776328
100	MP0004130_abnormal_muscle_cell	0.67658634

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	4.32315764
2	Hyperventilation (HP:0002883)	4.07787797
3	Pancreatic cysts (HP:0001737)	3.68631928
4	Congenital stationary night blindness (HP:0007642)	3.66066243
5	Febrile seizures (HP:0002373)	3.65060105
6	Atonic seizures (HP:0010819)	3.63807843
7	Focal seizures (HP:0007359)	3.52302524
8	True hermaphroditism (HP:0010459)	3.49996223
9	Pancreatic fibrosis (HP:0100732)	3.42150716
10	Abnormal respiratory motile cilium morphology (HP:0005938)	3.36284939
11	Abnormal respiratory epithelium morphology (HP:0012253)	3.36284939
12	Nephronophthisis (HP:0000090)	3.35428909
13	Molar tooth sign on MRI (HP:0002419)	3.21191711
14	Abnormality of midbrain morphology (HP:0002418)	3.21191711
15	Progressive cerebellar ataxia (HP:0002073)	3.16566200
16	Chronic otitis media (HP:0000389)	3.05800833
17	Broad-based gait (HP:0002136)	2.93938942
18	Protruding tongue (HP:0010808)	2.89355323
19	Dialeptic seizures (HP:0011146)	2.88414951
20	Hypothermia (HP:0002045)	2.77013126
21	Limb dystonia (HP:0002451)	2.74479925
22	Epileptic encephalopathy (HP:0200134)	2.72260124
23	Medial flaring of the eyebrow (HP:0010747)	2.71462810
24	Abnormality of the renal medulla (HP:0100957)	2.71163950
25	Absence seizures (HP:0002121)	2.69768538
26	Gaze-evoked nystagmus (HP:0000640)	2.60731107
27	Attenuation of retinal blood vessels (HP:0007843)	2.60264144
28	Type II lissencephaly (HP:0007260)	2.56208064
29	Abnormality of the renal cortex (HP:0011035)	2.49487092
30	Decreased central vision (HP:0007663)	2.47763775
31	Chronic sinusitis (HP:0011109)	2.47582721
32	Hemiparesis (HP:0001269)	2.45731950
33	Cystic liver disease (HP:0006706)	2.43983863
34	Generalized tonic-clonic seizures (HP:0002069)	2.41960735
35	Gait imbalance (HP:0002141)	2.39852880
36	Pendular nystagmus (HP:0012043)	2.39268960
37	Abolished electroretinogram (ERG) (HP:0000550)	2.29124665
38	Drooling (HP:0002307)	2.27867667
39	Congenital, generalized hypertrichosis (HP:0004540)	2.27833470
40	Inability to walk (HP:0002540)	2.26818792
41	Abnormal rod and cone electroretinograms (HP:0008323)	2.25675129
42	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.24147184
43	Abnormality of alanine metabolism (HP:0010916)	2.24147184
44	Hyperalaninemia (HP:0003348)	2.24147184
45	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.23159770
46	Myokymia (HP:0002411)	2.20298271
47	Clumsiness (HP:0002312)	2.14420079
48	Congenital sensorineural hearing impairment (HP:0008527)	2.12278769
49	Congenital primary aphakia (HP:0007707)	2.11890589
50	Renal cortical cysts (HP:0000803)	2.11527361
51	Excessive salivation (HP:0003781)	2.09469056
52	Chronic hepatic failure (HP:0100626)	2.09111030
53	Absent speech (HP:0001344)	2.08913002
54	Abnormal drinking behavior (HP:0030082)	2.08580717
55	Polydipsia (HP:0001959)	2.08580717
56	Cerebral hypomyelination (HP:0006808)	2.07634474
57	Mitochondrial inheritance (HP:0001427)	2.07382439
58	Methylmalonic acidemia (HP:0002912)	2.06632056
59	Concave nail (HP:0001598)	2.03737331
60	Optic nerve hypoplasia (HP:0000609)	2.00316423
61	Status epilepticus (HP:0002133)	1.99901456
62	Hemiplegia (HP:0002301)	1.99823363
63	Acute necrotizing encephalopathy (HP:0006965)	1.98790117
64	Agitation (HP:0000713)	1.98168616
65	Genital tract atresia (HP:0001827)	1.97849871
66	Genetic anticipation (HP:0003743)	1.97078450
67	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.96987599
68	Bilateral microphthalmos (HP:0007633)	1.95965926
69	Large for gestational age (HP:0001520)	1.94960542
70	Vaginal atresia (HP:0000148)	1.94629689
71	Anencephaly (HP:0002323)	1.94514167
72	Abnormality of the labia minora (HP:0012880)	1.94148042
73	Progressive macrocephaly (HP:0004481)	1.93366651
74	Nephrogenic diabetes insipidus (HP:0009806)	1.90667164
75	Sclerocornea (HP:0000647)	1.90649267
76	Male pseudohermaphroditism (HP:0000037)	1.90453538
77	Keratoconus (HP:0000563)	1.90421679
78	Increased corneal curvature (HP:0100692)	1.90421679
79	Enlarged penis (HP:0000040)	1.87146696
80	Increased CSF lactate (HP:0002490)	1.86126638
81	3-Methylglutaconic aciduria (HP:0003535)	1.83997758
82	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.82462599
83	Absent/shortened dynein arms (HP:0200106)	1.82462599
84	Bony spicule pigmentary retinopathy (HP:0007737)	1.82023952
85	Stomach cancer (HP:0012126)	1.81076022
86	Optic disc pallor (HP:0000543)	1.80247253
87	Methylmalonic aciduria (HP:0012120)	1.79441957
88	Polyphagia (HP:0002591)	1.79340615
89	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.78552232
90	Tubular atrophy (HP:0000092)	1.78023215
91	Progressive inability to walk (HP:0002505)	1.77949288
92	Lissencephaly (HP:0001339)	1.77580574
93	Abnormality of binocular vision (HP:0011514)	1.75880064
94	Diplopia (HP:0000651)	1.75880064
95	Abnormality of macular pigmentation (HP:0008002)	1.75723436
96	Intestinal atresia (HP:0011100)	1.75699822
97	Cerebellar dysplasia (HP:0007033)	1.72819401
98	Hyperglycinemia (HP:0002154)	1.72778343
99	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.71182940
100	CNS hypomyelination (HP:0003429)	1.68432315

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.98598458
2	CASK	4.71504670
3	ADRBK2	2.90055344
4	INSRR	2.88956327
5	EPHA4	2.55047742
6	PINK1	2.41143086
7	WNK3	2.27607512
8	MARK1	2.17772816
9	ZAK	2.10081097
10	DAPK2	2.08762742
11	GRK1	2.06719271
12	NTRK3	2.04376539
13	MAP4K2	1.97270889
14	BMPR1B	1.87321393
15	PNCK	1.86478326
16	MAPK13	1.85521531
17	PRKCG	1.72938230
18	OXSR1	1.69641051
19	MAP3K4	1.68956709
20	RIPK1	1.59320845
21	TLK1	1.56839424
22	PLK2	1.42419271
23	BMPR2	1.41415042
24	TXK	1.41270459
25	PRKCE	1.41151308
26	WNK4	1.35197261
27	NUAK1	1.34537914
28	STK39	1.31977972
29	ACVR1B	1.21806859
30	PAK3	1.21254526
31	PRKCI	1.20625783
32	MAP2K7	1.20210347
33	NTRK2	1.15511739
34	PLK4	1.08053582
35	DYRK2	1.06676335
36	CAMKK2	1.03241706
37	FGFR2	0.98261470
38	ADRBK1	0.97785386
39	MAP4K1	0.97181483
40	TAOK3	0.93071857
41	TNIK	0.89530924
42	MAPK15	0.89084504
43	SGK2	0.83301778
44	CAMK1	0.81992085
45	CAMK2A	0.79750868
46	CSNK1G2	0.78362086
47	PRKCQ	0.76513278
48	STK38L	0.73603016
49	TIE1	0.73194098
50	VRK1	0.72829400
51	PAK6	0.72467637
52	TRIM28	0.70622962
53	GRK5	0.70603174
54	SGK223	0.70459822
55	SGK494	0.70459822
56	PRKCZ	0.70394700
57	MKNK2	0.68078696
58	PTK2B	0.66934462
59	MINK1	0.66167916
60	PHKG2	0.65456625
61	PHKG1	0.65456625
62	PKN1	0.62301610
63	SIK2	0.61791939
64	DYRK3	0.61071436
65	TGFBR1	0.56157212
66	CAMKK1	0.55453034
67	STK11	0.55139948
68	PIK3CA	0.54732364
69	CDK19	0.53354552
70	UHMK1	0.53194939
71	DYRK1A	0.51793427
72	PRKACA	0.50815135
73	CSNK1G1	0.47006389
74	PRKCH	0.46935840
75	CDK5	0.45236601
76	CSNK1G3	0.45122502
77	MAP2K6	0.45028915
78	PLK3	0.44910243
79	CSNK1A1	0.42723495
80	PRKG1	0.42645331
81	MUSK	0.42605007
82	STK38	0.41778729
83	SGK1	0.41690370
84	KIT	0.41387252
85	PRKCA	0.39971368
86	IKBKB	0.39294514
87	NME1	0.39220918
88	PASK	0.38835691
89	DAPK3	0.38494117
90	CSNK1A1L	0.38228873
91	RIPK4	0.37766059
92	MAP2K4	0.37471925
93	CAMK2B	0.37438394
94	STK16	0.37285017
95	DAPK1	0.36985721
96	EPHB2	0.33946094
97	PRKCB	0.33738869
98	TEC	0.32108766
99	PDPK1	0.30402181
100	MAPKAPK5	0.30024336

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.76966283
2	Phototransduction_Homo sapiens_hsa04744	2.82550204
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.44620825
4	Morphine addiction_Homo sapiens_hsa05032	2.32371318
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.27219160
6	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.26444818
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.25532219
8	Taste transduction_Homo sapiens_hsa04742	2.15580038
9	GABAergic synapse_Homo sapiens_hsa04727	2.06869132
10	Olfactory transduction_Homo sapiens_hsa04740	1.95801528
11	Circadian entrainment_Homo sapiens_hsa04713	1.95445788
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.93648831
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.92777225
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.91567037
15	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.85058725
16	Parkinsons disease_Homo sapiens_hsa05012	1.82308231
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.80990610
18	Glutamatergic synapse_Homo sapiens_hsa04724	1.77958768
19	Insulin secretion_Homo sapiens_hsa04911	1.77715672
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.77268274
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.76772909
22	RNA polymerase_Homo sapiens_hsa03020	1.66397865
23	Protein export_Homo sapiens_hsa03060	1.61986122
24	Butanoate metabolism_Homo sapiens_hsa00650	1.61528542
25	Amphetamine addiction_Homo sapiens_hsa05031	1.44455247
26	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.35209714
27	Salivary secretion_Homo sapiens_hsa04970	1.33188303
28	Serotonergic synapse_Homo sapiens_hsa04726	1.31623465
29	Collecting duct acid secretion_Homo sapiens_hsa04966	1.30853996
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.29510221
31	Dopaminergic synapse_Homo sapiens_hsa04728	1.28366443
32	Calcium signaling pathway_Homo sapiens_hsa04020	1.26704643
33	Cocaine addiction_Homo sapiens_hsa05030	1.26351531
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.26202921
35	Alzheimers disease_Homo sapiens_hsa05010	1.25498892
36	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.23580993
37	Regulation of autophagy_Homo sapiens_hsa04140	1.20994838
38	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.18894456
39	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.16925261
40	Huntingtons disease_Homo sapiens_hsa05016	1.15564800
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.14578704
42	RNA degradation_Homo sapiens_hsa03018	1.11696763
43	Selenocompound metabolism_Homo sapiens_hsa00450	1.09699257
44	Gastric acid secretion_Homo sapiens_hsa04971	1.09531220
45	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.01954672
46	Cholinergic synapse_Homo sapiens_hsa04725	0.99280378
47	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.93519079
48	Homologous recombination_Homo sapiens_hsa03440	0.93012581
49	Fanconi anemia pathway_Homo sapiens_hsa03460	0.91469854
50	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.88159016
51	cAMP signaling pathway_Homo sapiens_hsa04024	0.81972277
52	Glycerolipid metabolism_Homo sapiens_hsa00561	0.80932977
53	Peroxisome_Homo sapiens_hsa04146	0.80836270
54	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.78512545
55	Sulfur relay system_Homo sapiens_hsa04122	0.78053592
56	ABC transporters_Homo sapiens_hsa02010	0.77001326
57	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.76163677
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.73848719
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.73216124
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.72223781
61	Basal transcription factors_Homo sapiens_hsa03022	0.71435009
62	Caffeine metabolism_Homo sapiens_hsa00232	0.70898926
63	Tyrosine metabolism_Homo sapiens_hsa00350	0.69781566
64	Long-term depression_Homo sapiens_hsa04730	0.69125895
65	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.67761834
66	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.67471361
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67077692
68	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.66411375
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66138037
70	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.65709780
71	Renin secretion_Homo sapiens_hsa04924	0.64597730
72	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.63638832
73	Ribosome_Homo sapiens_hsa03010	0.62157719
74	Histidine metabolism_Homo sapiens_hsa00340	0.60003702
75	Propanoate metabolism_Homo sapiens_hsa00640	0.59773849
76	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.58663310
77	Pancreatic secretion_Homo sapiens_hsa04972	0.58495482
78	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58202347
79	beta-Alanine metabolism_Homo sapiens_hsa00410	0.57275702
80	Mineral absorption_Homo sapiens_hsa04978	0.54822690
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.54151016
82	Retinol metabolism_Homo sapiens_hsa00830	0.52680438
83	Axon guidance_Homo sapiens_hsa04360	0.52042607
84	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.50480482
85	Purine metabolism_Homo sapiens_hsa00230	0.49838652
86	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.49230720
87	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.42301162
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42297722
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.41873283
90	Fat digestion and absorption_Homo sapiens_hsa04975	0.40496611
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.39575605
92	Type II diabetes mellitus_Homo sapiens_hsa04930	0.39147268
93	Primary immunodeficiency_Homo sapiens_hsa05340	0.38158898
94	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.36950806
95	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.34994718
96	Asthma_Homo sapiens_hsa05310	0.34840700
97	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.33732760
98	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.31667400
99	Metabolic pathways_Homo sapiens_hsa01100	0.31600733
100	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.30409093

LINC00672

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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