ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fucose catabolic process (GO:0019317)	4.05251746
2	L-fucose metabolic process (GO:0042354)	4.05251746
3	L-fucose catabolic process (GO:0042355)	4.05251746
4	behavioral response to nicotine (GO:0035095)	4.04068854
5	positive regulation of mitochondrial fission (GO:0090141)	3.99782035
6	platelet dense granule organization (GO:0060155)	3.86821095
7	DNA deamination (GO:0045006)	3.83339253
8	protein localization to cilium (GO:0061512)	3.68932897
9	ubiquinone biosynthetic process (GO:0006744)	3.61168821
10	indole-containing compound catabolic process (GO:0042436)	3.54923604
11	indolalkylamine catabolic process (GO:0046218)	3.54923604
12	tryptophan catabolic process (GO:0006569)	3.54923604
13	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.53310117
14	DNA double-strand break processing (GO:0000729)	3.45854130
15	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.43860782
16	ubiquinone metabolic process (GO:0006743)	3.39468846
17	indolalkylamine metabolic process (GO:0006586)	3.35760241
18	epithelial cilium movement (GO:0003351)	3.35449237
19	protein polyglutamylation (GO:0018095)	3.34107917
20	neural tube formation (GO:0001841)	3.33743446
21	dopamine transport (GO:0015872)	3.29778527
22	tryptophan metabolic process (GO:0006568)	3.29273227
23	mannosylation (GO:0097502)	3.28904671
24	multicellular organism reproduction (GO:0032504)	3.23873896
25	kynurenine metabolic process (GO:0070189)	3.21122217
26	preassembly of GPI anchor in ER membrane (GO:0016254)	3.19255627
27	detection of light stimulus involved in sensory perception (GO:0050962)	3.16225306
28	detection of light stimulus involved in visual perception (GO:0050908)	3.16225306
29	protein-cofactor linkage (GO:0018065)	3.14196218
30	amino acid salvage (GO:0043102)	3.13075196
31	L-methionine salvage (GO:0071267)	3.13075196
32	L-methionine biosynthetic process (GO:0071265)	3.13075196
33	protein complex biogenesis (GO:0070271)	3.12710987
34	S-adenosylmethionine metabolic process (GO:0046500)	3.08326936
35	negative regulation of telomere maintenance (GO:0032205)	3.06409729
36	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.06117807
37	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.06117807
38	pyrimidine nucleobase catabolic process (GO:0006208)	3.03625295
39	adaptation of signaling pathway (GO:0023058)	3.03288959
40	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.02038150
41	NADH dehydrogenase complex assembly (GO:0010257)	3.02038150
42	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.02038150
43	regulation of cilium movement (GO:0003352)	2.99439355
44	quinone biosynthetic process (GO:1901663)	2.94669471
45	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.93923444
46	intraciliary transport (GO:0042073)	2.93449652
47	regulation of mitochondrial fission (GO:0090140)	2.92251916
48	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.89664554
49	mitochondrial respiratory chain complex assembly (GO:0033108)	2.85024947
50	piRNA metabolic process (GO:0034587)	2.80902107
51	cilium morphogenesis (GO:0060271)	2.80424583
52	axoneme assembly (GO:0035082)	2.80080958
53	negative regulation of heart rate (GO:0010459)	2.79531583
54	iron-sulfur cluster assembly (GO:0016226)	2.78579489
55	metallo-sulfur cluster assembly (GO:0031163)	2.78579489
56	negative regulation of mast cell activation (GO:0033004)	2.72939443
57	sulfation (GO:0051923)	2.72562527
58	nucleobase catabolic process (GO:0046113)	2.71574333
59	GPI anchor metabolic process (GO:0006505)	2.71195428
60	regulation of action potential (GO:0098900)	2.70071180
61	response to pheromone (GO:0019236)	2.68626099
62	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.68145973
63	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.67221652
64	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.65517694
65	amine catabolic process (GO:0009310)	2.62797898
66	cellular biogenic amine catabolic process (GO:0042402)	2.62797898
67	peptidyl-histidine modification (GO:0018202)	2.61325478
68	cilium organization (GO:0044782)	2.61104362
69	neuronal action potential (GO:0019228)	2.60184241
70	cellular ketone body metabolic process (GO:0046950)	2.59111790
71	C-terminal protein lipidation (GO:0006501)	2.57526643
72	adenosine metabolic process (GO:0046085)	2.56589018
73	gamma-aminobutyric acid transport (GO:0015812)	2.56072498
74	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.55528940
75	protein K11-linked deubiquitination (GO:0035871)	2.53540175
76	C-terminal protein amino acid modification (GO:0018410)	2.53340550
77	cilium movement (GO:0003341)	2.52886219
78	cilium assembly (GO:0042384)	2.52428867
79	inositol phosphate catabolic process (GO:0071545)	2.52066612
80	sequestering of actin monomers (GO:0042989)	2.51884462
81	protein deneddylation (GO:0000338)	2.50354303
82	sperm motility (GO:0030317)	2.50283496
83	regulation of glucokinase activity (GO:0033131)	2.48946763
84	regulation of hexokinase activity (GO:1903299)	2.48946763
85	rRNA catabolic process (GO:0016075)	2.45907634
86	indole-containing compound metabolic process (GO:0042430)	2.44638198
87	cullin deneddylation (GO:0010388)	2.42342949
88	auditory receptor cell stereocilium organization (GO:0060088)	2.42089312
89	nonmotile primary cilium assembly (GO:0035058)	2.40701134
90	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.39652234
91	glycosphingolipid biosynthetic process (GO:0006688)	2.38971671
92	retinal cone cell development (GO:0046549)	2.38511944
93	response to nitrosative stress (GO:0051409)	2.37760243
94	positive regulation of prostaglandin secretion (GO:0032308)	2.37441806
95	protein neddylation (GO:0045116)	2.36936261
96	benzene-containing compound metabolic process (GO:0042537)	2.35809943
97	GPI anchor biosynthetic process (GO:0006506)	2.35724634
98	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.35607269
99	regulation of memory T cell differentiation (GO:0043380)	2.35584779
100	establishment of protein localization to Golgi (GO:0072600)	2.35158224

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.85705193
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.50002560
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.46087965
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.09999085
5	VDR_22108803_ChIP-Seq_LS180_Human	2.78473243
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.63437629
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.46968944
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.42370716
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.40813728
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.33254860
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.32468822
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.10170415
13	EWS_26573619_Chip-Seq_HEK293_Human	2.06989365
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04436170
15	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.00797547
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.98494285
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96421918
18	IRF1_19129219_ChIP-ChIP_H3396_Human	1.95125617
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.88425663
20	P300_19829295_ChIP-Seq_ESCs_Human	1.88188673
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.86937699
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.85282112
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.83489568
24	FUS_26573619_Chip-Seq_HEK293_Human	1.83426839
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.82348548
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.80099936
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.71243081
28	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.67979560
29	CBP_20019798_ChIP-Seq_JUKART_Human	1.67979560
30	VDR_23849224_ChIP-Seq_CD4+_Human	1.66302057
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62819387
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.61523619
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.56642116
34	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.47677692
35	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.47322918
36	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.41790589
37	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.41790589
38	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.40559877
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40406475
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.36040124
41	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.33631151
42	AR_20517297_ChIP-Seq_VCAP_Human	1.32397133
43	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31611966
44	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.29112134
45	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.28025815
46	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.27376872
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.27181895
48	BCAT_22108803_ChIP-Seq_LS180_Human	1.26977720
49	AR_25329375_ChIP-Seq_VCAP_Human	1.26954890
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26430667
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26430667
52	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.25998375
53	ELK1_19687146_ChIP-ChIP_HELA_Human	1.25657877
54	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.25088202
55	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.22852709
56	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.22774685
57	STAT3_23295773_ChIP-Seq_U87_Human	1.22769211
58	TCF4_23295773_ChIP-Seq_U87_Human	1.22226361
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21833558
60	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20535603
61	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.19713856
62	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.18981954
63	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.18862814
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.17664976
65	GATA3_26560356_Chip-Seq_TH2_Human	1.14787994
66	NCOR_22424771_ChIP-Seq_293T_Human	1.14246252
67	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14072371
68	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.13833580
69	HOXB7_26014856_ChIP-Seq_BT474_Human	1.13077700
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.13026397
71	NANOG_20526341_ChIP-Seq_ESCs_Human	1.11987084
72	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.10858756
73	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.10789643
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.10755729
75	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10166576
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.09592162
77	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.08762449
78	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.07533087
79	TCF4_22108803_ChIP-Seq_LS180_Human	1.07015712
80	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06400533
81	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.05800645
82	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.05347289
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03976910
84	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.03445364
85	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02600167
86	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.02027330
87	MYC_19829295_ChIP-Seq_ESCs_Human	1.01042097
88	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.00413606
89	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.99972507
90	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.99836796
91	ERA_21632823_ChIP-Seq_H3396_Human	0.99672598
92	RNF2_27304074_Chip-Seq_NSC_Mouse	0.99025338
93	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98347018
94	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.98347018
95	FOXP3_21729870_ChIP-Seq_TREG_Human	0.97984953
96	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.97622428
97	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96811586
98	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95448042
99	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.95436743
100	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.95251129

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.25199786
2	MP0002102_abnormal_ear_morphology	3.01271163
3	MP0002837_dystrophic_cardiac_calcinosis	2.56045082
4	MP0006072_abnormal_retinal_apoptosis	2.41144844
5	MP0005646_abnormal_pituitary_gland	2.40712880
6	MP0002876_abnormal_thyroid_physiology	2.34542139
7	MP0008877_abnormal_DNA_methylation	2.34348315
8	MP0005551_abnormal_eye_electrophysiolog	2.19513009
9	MP0001984_abnormal_olfaction	2.17318855
10	MP0003195_calcinosis	2.15420333
11	MP0001968_abnormal_touch/_nociception	2.09132109
12	MP0001986_abnormal_taste_sensitivity	2.07092663
13	MP0005253_abnormal_eye_physiology	2.04957550
14	MP0003011_delayed_dark_adaptation	2.03851923
15	MP0001529_abnormal_vocalization	1.98938576
16	MP0003136_yellow_coat_color	1.84246904
17	MP0005084_abnormal_gallbladder_morpholo	1.76889285
18	MP0008872_abnormal_physiological_respon	1.75658228
19	MP0006276_abnormal_autonomic_nervous	1.73237413
20	MP0001501_abnormal_sleep_pattern	1.71010959
21	MP0005645_abnormal_hypothalamus_physiol	1.68716961
22	MP0008875_abnormal_xenobiotic_pharmacok	1.67074915
23	MP0000372_irregular_coat_pigmentation	1.64294121
24	MP0009745_abnormal_behavioral_response	1.63905292
25	MP0004142_abnormal_muscle_tone	1.60860272
26	MP0009046_muscle_twitch	1.59063057
27	MP0002653_abnormal_ependyma_morphology	1.56602240
28	MP0003806_abnormal_nucleotide_metabolis	1.53878937
29	MP0001905_abnormal_dopamine_level	1.53243419
30	MP0002160_abnormal_reproductive_system	1.50322693
31	MP0002736_abnormal_nociception_after	1.48466933
32	MP0003787_abnormal_imprinting	1.47646968
33	MP0005410_abnormal_fertilization	1.46883788
34	MP0002638_abnormal_pupillary_reflex	1.45641784
35	MP0002272_abnormal_nervous_system	1.44170901
36	MP0008789_abnormal_olfactory_epithelium	1.43645807
37	MP0010386_abnormal_urinary_bladder	1.41207156
38	MP0009697_abnormal_copulation	1.39788987
39	MP0005389_reproductive_system_phenotype	1.36792211
40	MP0006292_abnormal_olfactory_placode	1.34189660
41	MP0006036_abnormal_mitochondrial_physio	1.32431380
42	MP0001764_abnormal_homeostasis	1.32056658
43	MP0008995_early_reproductive_senescence	1.31891203
44	MP0003724_increased_susceptibility_to	1.31851296
45	MP0004133_heterotaxia	1.29738323
46	MP0005671_abnormal_response_to	1.28218672
47	MP0000465_gastrointestinal_hemorrhage	1.27949305
48	MP0004215_abnormal_myocardial_fiber	1.27838232
49	MP0000427_abnormal_hair_cycle	1.24426013
50	MP0001486_abnormal_startle_reflex	1.22645954
51	MP0000631_abnormal_neuroendocrine_gland	1.20813206
52	MP0002572_abnormal_emotion/affect_behav	1.17883068
53	MP0005499_abnormal_olfactory_system	1.17277150
54	MP0005394_taste/olfaction_phenotype	1.17277150
55	MP0001919_abnormal_reproductive_system	1.16382718
56	MP0004484_altered_response_of	1.15096987
57	MP0003646_muscle_fatigue	1.13390892
58	MP0002735_abnormal_chemical_nociception	1.12353259
59	MP0004145_abnormal_muscle_electrophysio	1.12255413
60	MP0009764_decreased_sensitivity_to	1.12201490
61	MP0005075_abnormal_melanosome_morpholog	1.08572228
62	MP0002928_abnormal_bile_duct	1.08244514
63	MP0001970_abnormal_pain_threshold	1.05649820
64	MP0004043_abnormal_pH_regulation	1.04885076
65	MP0001485_abnormal_pinna_reflex	1.04374995
66	MP0002733_abnormal_thermal_nociception	1.03097682
67	MP0002557_abnormal_social/conspecific_i	1.01923691
68	MP0002234_abnormal_pharynx_morphology	1.01593730
69	MP0005167_abnormal_blood-brain_barrier	1.00934467
70	MP0000230_abnormal_systemic_arterial	0.94794387
71	MP0002751_abnormal_autonomic_nervous	0.94742411
72	MP0005423_abnormal_somatic_nervous	0.92957906
73	MP0003635_abnormal_synaptic_transmissio	0.92692046
74	MP0003122_maternal_imprinting	0.92673798
75	MP0004147_increased_porphyrin_level	0.92136569
76	MP0002064_seizures	0.91133755
77	MP0005386_behavior/neurological_phenoty	0.89434776
78	MP0004924_abnormal_behavior	0.89434776
79	MP0003698_abnormal_male_reproductive	0.89029418
80	MP0003252_abnormal_bile_duct	0.88364658
81	MP0008775_abnormal_heart_ventricle	0.86192765
82	MP0003718_maternal_effect	0.85362793
83	MP0002752_abnormal_somatic_nervous	0.82141893
84	MP0001502_abnormal_circadian_rhythm	0.81512089
85	MP0002063_abnormal_learning/memory/cond	0.81206346
86	MP0000026_abnormal_inner_ear	0.80997882
87	MP0002067_abnormal_sensory_capabilities	0.80652322
88	MP0009785_altered_susceptibility_to	0.80537180
89	MP0001929_abnormal_gametogenesis	0.79658094
90	MP0005195_abnormal_posterior_eye	0.78784111
91	MP0002229_neurodegeneration	0.75875323
92	MP0004885_abnormal_endolymph	0.75807566
93	MP0001963_abnormal_hearing_physiology	0.74911229
94	MP0008058_abnormal_DNA_repair	0.74587183
95	MP0005379_endocrine/exocrine_gland_phen	0.72859503
96	MP0003121_genomic_imprinting	0.72827330
97	MP0009780_abnormal_chondrocyte_physiolo	0.72739937
98	MP0005266_abnormal_metabolism	0.72121397
99	MP0003186_abnormal_redox_activity	0.72075946
100	MP0002127_abnormal_cardiovascular_syste	0.71040603

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	4.11561843
2	Pancreatic cysts (HP:0001737)	4.03598684
3	Pancreatic fibrosis (HP:0100732)	3.66208950
4	Type II lissencephaly (HP:0007260)	3.65003807
5	Molar tooth sign on MRI (HP:0002419)	3.62439474
6	Abnormality of midbrain morphology (HP:0002418)	3.62439474
7	Congenital stationary night blindness (HP:0007642)	3.52602712
8	Nephronophthisis (HP:0000090)	3.14809785
9	Medial flaring of the eyebrow (HP:0010747)	3.07082960
10	3-Methylglutaconic aciduria (HP:0003535)	3.06347577
11	Acute necrotizing encephalopathy (HP:0006965)	2.90585168
12	Abolished electroretinogram (ERG) (HP:0000550)	2.88977217
13	Retinal dysplasia (HP:0007973)	2.88956991
14	Lissencephaly (HP:0001339)	2.83075058
15	Inability to walk (HP:0002540)	2.81428084
16	Abnormality of the renal cortex (HP:0011035)	2.79801427
17	Renal cortical cysts (HP:0000803)	2.79415176
18	Abnormal rod and cone electroretinograms (HP:0008323)	2.78624922
19	Hyperventilation (HP:0002883)	2.73617991
20	Bile duct proliferation (HP:0001408)	2.73605284
21	Abnormal biliary tract physiology (HP:0012439)	2.73605284
22	Abnormality of the renal medulla (HP:0100957)	2.66824138
23	Mitochondrial inheritance (HP:0001427)	2.66436436
24	Abnormal mitochondria in muscle tissue (HP:0008316)	2.58600690
25	Nephrogenic diabetes insipidus (HP:0009806)	2.57104990
26	Progressive macrocephaly (HP:0004481)	2.55560103
27	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.54955545
28	Aplasia/hypoplasia of the uterus (HP:0008684)	2.54867228
29	Gait imbalance (HP:0002141)	2.51747128
30	Acute encephalopathy (HP:0006846)	2.51107330
31	Thyroiditis (HP:0100646)	2.50038794
32	Congenital primary aphakia (HP:0007707)	2.49998670
33	Progressive inability to walk (HP:0002505)	2.49171990
34	Cystic liver disease (HP:0006706)	2.47433089
35	Attenuation of retinal blood vessels (HP:0007843)	2.43034171
36	Increased CSF lactate (HP:0002490)	2.42231497
37	IgG deficiency (HP:0004315)	2.39117229
38	Severe combined immunodeficiency (HP:0004430)	2.38579359
39	Hepatocellular necrosis (HP:0001404)	2.38355271
40	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.35332789
41	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.35332789
42	Chronic hepatic failure (HP:0100626)	2.34628382
43	Clumsiness (HP:0002312)	2.33097795
44	Cerebellar dysplasia (HP:0007033)	2.29728684
45	Hepatic necrosis (HP:0002605)	2.26925861
46	Hypothermia (HP:0002045)	2.26462419
47	Male pseudohermaphroditism (HP:0000037)	2.25965692
48	Pachygyria (HP:0001302)	2.25761769
49	Stomatitis (HP:0010280)	2.19229823
50	Sclerocornea (HP:0000647)	2.15129163
51	Absent speech (HP:0001344)	2.14770555
52	Abnormality of eosinophils (HP:0001879)	2.08061933
53	Hyperglycinemia (HP:0002154)	2.07675492
54	Polydipsia (HP:0001959)	2.06297508
55	Abnormal drinking behavior (HP:0030082)	2.06297508
56	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.06188155
57	Thyroid-stimulating hormone excess (HP:0002925)	2.05818753
58	Optic disc pallor (HP:0000543)	2.04013591
59	Congenital hepatic fibrosis (HP:0002612)	2.02851337
60	Lipid accumulation in hepatocytes (HP:0006561)	2.02242047
61	Methylmalonic acidemia (HP:0002912)	2.01228436
62	Methylmalonic aciduria (HP:0012120)	1.99625044
63	Ketosis (HP:0001946)	1.99410737
64	Progressive microcephaly (HP:0000253)	1.98587311
65	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.97968613
66	Abnormality of alanine metabolism (HP:0010916)	1.97968613
67	Hyperalaninemia (HP:0003348)	1.97968613
68	Decreased central vision (HP:0007663)	1.96811796
69	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.89343245
70	Postaxial hand polydactyly (HP:0001162)	1.87236934
71	Postaxial foot polydactyly (HP:0001830)	1.87083807
72	Hyperglycinuria (HP:0003108)	1.86292370
73	Mesangial abnormality (HP:0001966)	1.86244678
74	Increased corneal curvature (HP:0100692)	1.86170556
75	Keratoconus (HP:0000563)	1.86170556
76	Lactic acidosis (HP:0003128)	1.86019859
77	Abnormal protein glycosylation (HP:0012346)	1.84971393
78	Abnormal glycosylation (HP:0012345)	1.84971393
79	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.84971393
80	Abnormal protein N-linked glycosylation (HP:0012347)	1.84971393
81	Increased serum lactate (HP:0002151)	1.84751356
82	Broad-based gait (HP:0002136)	1.83833864
83	Genital tract atresia (HP:0001827)	1.83141944
84	Pendular nystagmus (HP:0012043)	1.83082930
85	Severe muscular hypotonia (HP:0006829)	1.82271042
86	Hypoplasia of the uterus (HP:0000013)	1.81381695
87	Adactyly (HP:0009776)	1.80981797
88	Vaginal atresia (HP:0000148)	1.80881300
89	Tubular atrophy (HP:0000092)	1.80123882
90	Large for gestational age (HP:0001520)	1.80095225
91	Occipital encephalocele (HP:0002085)	1.78098575
92	Anencephaly (HP:0002323)	1.77362631
93	Abnormality of serine family amino acid metabolism (HP:0010894)	1.76277613
94	Abnormality of glycine metabolism (HP:0010895)	1.76277613
95	Abnormal respiratory motile cilium morphology (HP:0005938)	1.76276365
96	Abnormal respiratory epithelium morphology (HP:0012253)	1.76276365
97	Short tibia (HP:0005736)	1.75074351
98	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.74129160
99	Gaze-evoked nystagmus (HP:0000640)	1.73653414
100	Eosinophilia (HP:0001880)	1.72762949

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	4.50298322
2	MAP4K2	4.11299254
3	FRK	3.69977284
4	TXK	2.41321530
5	BCKDK	2.38855824
6	TAOK3	2.33279519
7	TRIM28	2.31791889
8	ADRBK2	2.28811081
9	NUAK1	2.27965037
10	MAP2K7	2.13406055
11	ZAK	2.06941512
12	TLK1	2.05734945
13	WNK3	2.04097932
14	BMPR1B	1.94735412
15	GRK1	1.94347934
16	EPHA3	1.84544867
17	CSNK1G3	1.81372997
18	BCR	1.79018274
19	CSNK1A1L	1.68522992
20	MAP3K4	1.67226478
21	CSNK1G2	1.66159270
22	MAPK13	1.64747702
23	CSNK1G1	1.43495828
24	DYRK2	1.38968553
25	WNK4	1.36422772
26	ERBB3	1.31222794
27	MARK3	1.30394934
28	OBSCN	1.25268325
29	INSRR	1.21047719
30	RPS6KA4	1.16363549
31	MARK1	1.13845818
32	CASK	1.11811813
33	GRK6	1.11628710
34	DYRK3	1.09528906
35	CDK19	1.06398336
36	SIK2	1.04739798
37	CAMKK2	1.00721763
38	OXSR1	0.99601904
39	MST4	0.99496213
40	TNIK	0.96141250
41	MUSK	0.92854707
42	PHKG2	0.90601160
43	PHKG1	0.90601160
44	RPS6KA5	0.86942690
45	VRK1	0.78743965
46	IKBKB	0.78426691
47	NME1	0.78235149
48	PRKCE	0.77824911
49	PAK3	0.77284137
50	MAPKAPK3	0.72910566
51	VRK2	0.70591562
52	MYLK	0.69604280
53	ADRBK1	0.69341777
54	TIE1	0.67851804
55	SIK3	0.66946892
56	PRKCQ	0.66649777
57	KIT	0.66061139
58	DAPK2	0.65534473
59	NEK2	0.65319302
60	LIMK1	0.62766298
61	STK39	0.58892485
62	STK38L	0.58042259
63	PTK2B	0.57390279
64	LATS1	0.56715477
65	TESK2	0.55694945
66	FLT3	0.55397099
67	TEC	0.54259700
68	EIF2AK3	0.53986850
69	ACVR1B	0.53850637
70	CSNK1A1	0.52533624
71	CSF1R	0.52320953
72	IKBKE	0.51107523
73	MINK1	0.48987096
74	CHUK	0.45893224
75	KDR	0.45674652
76	MAP2K6	0.45466397
77	PAK6	0.43742628
78	EPHA4	0.43431704
79	STK16	0.43000052
80	CAMK2A	0.41819012
81	BTK	0.41544885
82	SYK	0.41115693
83	PRKCG	0.40017311
84	TNK2	0.39891858
85	PKN1	0.39118865
86	SRPK1	0.38246876
87	PIM2	0.37826912
88	NTRK2	0.37592181
89	PRKACA	0.37437241
90	CDK3	0.36463461
91	PLK2	0.35607611
92	CSNK1D	0.35596778
93	CCNB1	0.35135115
94	BMPR2	0.34988705
95	LYN	0.34894558
96	IRAK1	0.33650208
97	ABL1	0.33153321
98	IGF1R	0.32413054
99	GRK7	0.31716649
100	ITK	0.31540377

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.76568576
2	Phototransduction_Homo sapiens_hsa04744	2.65256814
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.61868019
4	Protein export_Homo sapiens_hsa03060	2.47548121
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.37338370
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.36413020
7	Butanoate metabolism_Homo sapiens_hsa00650	2.31381863
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.26630950
9	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.24524735
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.13505436
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.08179226
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.06569263
13	Parkinsons disease_Homo sapiens_hsa05012	1.97353406
14	Propanoate metabolism_Homo sapiens_hsa00640	1.97286428
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.93372840
16	Olfactory transduction_Homo sapiens_hsa04740	1.84774923
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.84255703
18	Primary immunodeficiency_Homo sapiens_hsa05340	1.68684811
19	Regulation of autophagy_Homo sapiens_hsa04140	1.64444952
20	RNA polymerase_Homo sapiens_hsa03020	1.63073017
21	Caffeine metabolism_Homo sapiens_hsa00232	1.61152726
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.57523175
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.56674986
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.53836805
25	Basal transcription factors_Homo sapiens_hsa03022	1.43918330
26	Nicotine addiction_Homo sapiens_hsa05033	1.42860176
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.41977703
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.40317260
29	Peroxisome_Homo sapiens_hsa04146	1.38224922
30	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.33912469
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.33409612
32	RNA degradation_Homo sapiens_hsa03018	1.27745667
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.24064777
34	Taste transduction_Homo sapiens_hsa04742	1.22294971
35	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.21316923
36	Proteasome_Homo sapiens_hsa03050	1.20660627
37	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.15817817
38	Homologous recombination_Homo sapiens_hsa03440	1.15282866
39	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.15065015
40	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.14975231
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.12318002
42	Asthma_Homo sapiens_hsa05310	1.11146268
43	Morphine addiction_Homo sapiens_hsa05032	1.07492329
44	Alzheimers disease_Homo sapiens_hsa05010	1.06985342
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.05892849
46	Huntingtons disease_Homo sapiens_hsa05016	1.05106637
47	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.01715890
48	GABAergic synapse_Homo sapiens_hsa04727	0.99570879
49	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.97331518
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.95725503
51	Purine metabolism_Homo sapiens_hsa00230	0.93265189
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.93131204
53	Pyrimidine metabolism_Homo sapiens_hsa00240	0.92309959
54	Circadian rhythm_Homo sapiens_hsa04710	0.90928563
55	Cardiac muscle contraction_Homo sapiens_hsa04260	0.89569244
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.88021987
57	Sulfur metabolism_Homo sapiens_hsa00920	0.86078178
58	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.85441537
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.83904300
60	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.81796743
61	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.80904667
62	Fatty acid elongation_Homo sapiens_hsa00062	0.80760711
63	Circadian entrainment_Homo sapiens_hsa04713	0.79923704
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.79465778
65	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.79011920
66	Retinol metabolism_Homo sapiens_hsa00830	0.78173641
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.76427969
68	Metabolic pathways_Homo sapiens_hsa01100	0.76316975
69	Steroid biosynthesis_Homo sapiens_hsa00100	0.73135209
70	Salivary secretion_Homo sapiens_hsa04970	0.72437092
71	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.68940321
72	ABC transporters_Homo sapiens_hsa02010	0.63477113
73	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.61466050
74	One carbon pool by folate_Homo sapiens_hsa00670	0.60916716
75	Type I diabetes mellitus_Homo sapiens_hsa04940	0.60659470
76	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.57706732
77	Graft-versus-host disease_Homo sapiens_hsa05332	0.55902634
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.55490630
79	Rheumatoid arthritis_Homo sapiens_hsa05323	0.53766068
80	Calcium signaling pathway_Homo sapiens_hsa04020	0.51285959
81	Serotonergic synapse_Homo sapiens_hsa04726	0.51198317
82	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.49808131
83	Allograft rejection_Homo sapiens_hsa05330	0.49678695
84	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.48455446
85	Sulfur relay system_Homo sapiens_hsa04122	0.46973743
86	Dopaminergic synapse_Homo sapiens_hsa04728	0.46223630
87	Fat digestion and absorption_Homo sapiens_hsa04975	0.44784849
88	Glutathione metabolism_Homo sapiens_hsa00480	0.42719093
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42590720
90	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.41559746
91	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.40284243
92	Glutamatergic synapse_Homo sapiens_hsa04724	0.40256871
93	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.40050146
94	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38723056
95	Base excision repair_Homo sapiens_hsa03410	0.38544236
96	Fatty acid degradation_Homo sapiens_hsa00071	0.38318509
97	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.37309578
98	Insulin secretion_Homo sapiens_hsa04911	0.36758216
99	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.35176843
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.33267696

LINC00674

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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