ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of guanylate cyclase activity (GO:0031282)	6.75272566
2	intestinal absorption (GO:0050892)	6.35595721
3	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	6.05485702
4	cellular glucuronidation (GO:0052695)	5.87338252
5	angiotensin maturation (GO:0002003)	5.77221623
6	sulfate transmembrane transport (GO:1902358)	5.73702476
7	uronic acid metabolic process (GO:0006063)	5.65515591
8	glucuronate metabolic process (GO:0019585)	5.65515591
9	flavonoid metabolic process (GO:0009812)	5.12405959
10	epoxygenase P450 pathway (GO:0019373)	5.11885272
11	positive regulation of guanylate cyclase activity (GO:0031284)	4.94712898
12	bile acid and bile salt transport (GO:0015721)	4.93425231
13	renal system process involved in regulation of blood volume (GO:0001977)	4.89420792
14	positive regulation of respiratory burst (GO:0060267)	4.87954896
15	oligosaccharide biosynthetic process (GO:0009312)	4.82194423
16	regulation of systemic arterial blood pressure by hormone (GO:0001990)	4.77953063
17	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	4.77953063
18	endocrine process (GO:0050886)	4.77953063
19	receptor guanylyl cyclase signaling pathway (GO:0007168)	4.77104943
20	ethanol oxidation (GO:0006069)	4.74774046
21	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.71162925
22	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	4.70345924
23	sulfate transport (GO:0008272)	4.65778624
24	O-glycan processing (GO:0016266)	4.47509757
25	maintenance of gastrointestinal epithelium (GO:0030277)	4.46184066
26	NADH metabolic process (GO:0006734)	4.45255871
27	sperm capacitation (GO:0048240)	4.27581074
28	fat-soluble vitamin biosynthetic process (GO:0042362)	4.24489816
29	regulation of vitamin metabolic process (GO:0030656)	4.20727771
30	regulation of systemic arterial blood pressure (GO:0003073)	4.13928065
31	regulation of cGMP biosynthetic process (GO:0030826)	4.10170839
32	nucleoside diphosphate biosynthetic process (GO:0009133)	4.04949825
33	glomerular filtration (GO:0003094)	4.02057562
34	regulation of bile acid biosynthetic process (GO:0070857)	3.99187677
35	ethanol metabolic process (GO:0006067)	3.98090520
36	glucocorticoid biosynthetic process (GO:0006704)	3.89114446
37	positive regulation of pseudopodium assembly (GO:0031274)	3.87064178
38	regulation of cellular extravasation (GO:0002691)	3.85532885
39	desmosome organization (GO:0002934)	3.84709341
40	drug metabolic process (GO:0017144)	3.83487816
41	transcytosis (GO:0045056)	3.82791722
42	diacylglycerol metabolic process (GO:0046339)	3.74207206
43	regulation of respiratory burst (GO:0060263)	3.67875538
44	antimicrobial humoral response (GO:0019730)	3.67759730
45	digestive system process (GO:0022600)	3.64995166
46	renal filtration (GO:0097205)	3.63754328
47	cGMP-mediated signaling (GO:0019934)	3.63585295
48	digestion (GO:0007586)	3.61191234
49	bicarbonate transport (GO:0015701)	3.60850133
50	renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	3.56555969
51	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.56305360
52	antibacterial humoral response (GO:0019731)	3.54177251
53	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.53198611
54	receptor recycling (GO:0001881)	3.52988617
55	lipoprotein transport (GO:0042953)	3.51348389
56	excretion (GO:0007588)	3.48785764
57	regulation of cholesterol homeostasis (GO:2000188)	3.47380724
58	intestinal epithelial cell development (GO:0060576)	3.45841957
59	regulation of pseudopodium assembly (GO:0031272)	3.44084331
60	sodium ion homeostasis (GO:0055078)	3.41276068
61	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.33934393
62	regulation of cGMP metabolic process (GO:0030823)	3.33651289
63	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.30760351
64	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.30760351
65	cellular response to pH (GO:0071467)	3.29050878
66	sulfur compound transport (GO:0072348)	3.28237706
67	hormone catabolic process (GO:0042447)	3.27343022
68	vitamin transmembrane transport (GO:0035461)	3.23752021
69	drug transmembrane transport (GO:0006855)	3.23301795
70	epithelial structure maintenance (GO:0010669)	3.20382467
71	urea cycle (GO:0000050)	3.16986206
72	phenylpropanoid metabolic process (GO:0009698)	3.16700014
73	multicellular organismal water homeostasis (GO:0050891)	3.10446062
74	sphingomyelin metabolic process (GO:0006684)	3.05076988
75	auditory receptor cell differentiation (GO:0042491)	3.03293158
76	urea metabolic process (GO:0019627)	3.02841654
77	positive regulation of glycoprotein metabolic process (GO:1903020)	2.98728376
78	drug transport (GO:0015893)	2.97977094
79	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.97036968
80	thrombin receptor signaling pathway (GO:0070493)	2.96550127
81	actin filament depolymerization (GO:0030042)	2.94207981
82	cGMP biosynthetic process (GO:0006182)	2.93195083
83	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.92589950
84	positive regulation of fatty acid oxidation (GO:0046321)	2.90478256
85	sexual reproduction (GO:0019953)	2.90349454
86	GDP-mannose metabolic process (GO:0019673)	2.89863109
87	drug catabolic process (GO:0042737)	2.86668160
88	positive regulation of lipid catabolic process (GO:0050996)	2.86667805
89	positive regulation of cGMP biosynthetic process (GO:0030828)	2.85100946
90	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.84758610
91	amino-acid betaine transport (GO:0015838)	2.84607581
92	carnitine transport (GO:0015879)	2.84607581
93	COPII vesicle coating (GO:0048208)	2.83628163
94	regulation of protein glycosylation (GO:0060049)	2.83468757
95	vitamin transport (GO:0051180)	2.82171433
96	labyrinthine layer development (GO:0060711)	2.82078930
97	exogenous drug catabolic process (GO:0042738)	2.81450612
98	nucleotide-sugar biosynthetic process (GO:0009226)	2.80919377
99	fructose metabolic process (GO:0006000)	2.78140218
100	monovalent inorganic cation homeostasis (GO:0055067)	2.76245327

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CDX2_20551321_ChIP-Seq_CACO-2_Human	5.17529780
2	SOX2_27498859_Chip-Seq_STOMACH_Mouse	3.33284706
3	GATA4_25053715_ChIP-Seq_YYC3_Human	2.93341338
4	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.88521719
5	GATA6_25053715_ChIP-Seq_YYC3_Human	2.80744361
6	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.79157876
7	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.72214489
8	SOX2_20726797_ChIP-Seq_SW620_Human	2.68080560
9	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.58786130
10	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.45058031
11	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.32657311
12	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.31120132
13	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.21604685
14	FOXO3_23340844_ChIP-Seq_DLD1_Human	2.21555923
15	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.15282133
16	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.15233105
17	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.13356537
18	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.12605732
19	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.12287545
20	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	2.07698486
21	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.07150357
22	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.02723356
23	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.92596709
24	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.86313913
25	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.82866758
26	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.82421718
27	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.81769820
28	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.78501746
29	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.78152127
30	KLF5_25053715_ChIP-Seq_YYC3_Human	1.76713521
31	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.75440962
32	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.73928434
33	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.67671141
34	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.62439064
35	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.60207995
36	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.58468211
37	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.58355862
38	CDX2_22108803_ChIP-Seq_LS180_Human	1.57726324
39	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.57472761
40	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.55630070
41	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.48626154
42	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.47824854
43	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.47756562
44	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.44051245
45	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.42142617
46	RACK7_27058665_Chip-Seq_MCF-7_Human	1.39735112
47	DROSHA_22980978_ChIP-Seq_HELA_Human	1.38525513
48	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.38175024
49	LXR_22292898_ChIP-Seq_THP-1_Human	1.35198085
50	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.31302357
51	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.30845143
52	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.28696257
53	CEBPB_22108803_ChIP-Seq_LS180_Human	1.26210043
54	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.26144621
55	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.24932291
56	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.24394884
57	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.17663691
58	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.13075409
59	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.12555074
60	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.11904722
61	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.07942602
62	TP63_22573176_ChIP-Seq_HFKS_Human	1.04334208
63	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.04074092
64	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.02659655
65	RXR_22108803_ChIP-Seq_LS180_Human	1.01936660
66	GATA2_19941826_ChIP-Seq_K562_Human	0.98968088
67	SA1_27219007_Chip-Seq_Bcells_Human	0.98929590
68	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.98609285
69	NANOG_20526341_ChIP-Seq_ESCs_Human	0.97479263
70	AHR_22903824_ChIP-Seq_MCF-7_Human	0.95891808
71	GATA1_19941826_ChIP-Seq_K562_Human	0.95478960
72	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.94130348
73	ZNF263_19887448_ChIP-Seq_K562_Human	0.92782370
74	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.92066809
75	STAT1_20625510_ChIP-Seq_HELA_Human	0.90906431
76	CTCF_27219007_Chip-Seq_Bcells_Human	0.90879697
77	CLOCK_20551151_ChIP-Seq_293T_Human	0.90592362
78	AR_21909140_ChIP-Seq_LNCAP_Human	0.90573066
79	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.88517570
80	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.88054217
81	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.87713142
82	TP63_23658742_ChIP-Seq_EP156T_Human	0.86856824
83	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.86708447
84	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.85946485
85	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.85548340
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.84488875
87	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.83898849
88	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.83604959
89	BCL6_27268052_Chip-Seq_Bcells_Human	0.82829245
90	CREB1_26743006_Chip-Seq_LNCaP_Human	0.82114111
91	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.81113876
92	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.79876133
93	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	0.78678935
94	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.77539997
95	CTCF_20526341_ChIP-Seq_ESCs_Human	0.77512742
96	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.77318515
97	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.76776755
98	CJUN_26792858_Chip-Seq_BT549_Human	0.76078913
99	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.75785202
100	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.75522534

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	5.74906848
2	MP0002139_abnormal_hepatobiliary_system	5.59956960
3	MP0005360_urolithiasis	4.40715587
4	MP0008004_abnormal_stomach_pH	3.82738480
5	MP0005085_abnormal_gallbladder_physiolo	3.76119400
6	MP0004264_abnormal_extraembryonic_tissu	3.55948447
7	MP0005365_abnormal_bile_salt	3.42338433
8	MP0001664_abnormal_digestion	3.26157649
9	MP0004043_abnormal_pH_regulation	3.15637597
10	MP0001666_abnormal_nutrient_absorption	3.12918313
11	MP0010352_gastrointestinal_tract_polyps	2.98137202
12	MP0003866_abnormal_defecation	2.80623630
13	MP0010155_abnormal_intestine_physiology	2.66538604
14	MP0009379_abnormal_foot_pigmentation	2.55976824
15	MP0003868_abnormal_feces_composition	2.52711442
16	MP0003183_abnormal_peptide_metabolism	2.45490561
17	MP0001765_abnormal_ion_homeostasis	2.29105091
18	MP0000490_abnormal_crypts_of	2.26741392
19	MP0004019_abnormal_vitamin_homeostasis	2.14852954
20	MP0001873_stomach_inflammation	2.08477668
21	MP0001663_abnormal_digestive_system	2.06309344
22	MP0000477_abnormal_intestine_morphology	2.06110231
23	MP0004147_increased_porphyrin_level	2.02585850
24	MP0005670_abnormal_white_adipose	2.02124890
25	MP0002796_impaired_skin_barrier	2.00116173
26	MP0005381_digestive/alimentary_phenotyp	1.89560887
27	MP0002138_abnormal_hepatobiliary_system	1.81163080
28	MP0005409_darkened_coat_color	1.73820448
29	MP0005636_abnormal_mineral_homeostasis	1.73222838
30	MP0000462_abnormal_digestive_system	1.62744678
31	MP0003252_abnormal_bile_duct	1.55744262
32	MP0009643_abnormal_urine_homeostasis	1.51152625
33	MP0005166_decreased_susceptibility_to	1.49725204
34	MP0005451_abnormal_body_composition	1.48122113
35	MP0000678_abnormal_parathyroid_gland	1.47998771
36	MP0004782_abnormal_surfactant_physiolog	1.43292026
37	MP0009840_abnormal_foam_cell	1.39122077
38	MP0003879_abnormal_hair_cell	1.38145334
39	MP0005501_abnormal_skin_physiology	1.32847877
40	MP0003806_abnormal_nucleotide_metabolis	1.29361384
41	MP0002876_abnormal_thyroid_physiology	1.28591668
42	MP0000566_synostosis	1.28508931
43	MP0002098_abnormal_vibrissa_morphology	1.27404636
44	MP0001756_abnormal_urination	1.24599891
45	MP0000465_gastrointestinal_hemorrhage	1.22635168
46	MP0008875_abnormal_xenobiotic_pharmacok	1.21482787
47	MP0010329_abnormal_lipoprotein_level	1.20862745
48	MP0000470_abnormal_stomach_morphology	1.20150780
49	MP0002136_abnormal_kidney_physiology	1.18043966
50	MP0002009_preneoplasia	1.15585591
51	MP0005310_abnormal_salivary_gland	1.13827168
52	MP0005332_abnormal_amino_acid	1.13590549
53	MP0000537_abnormal_urethra_morphology	1.12274160
54	MP0000230_abnormal_systemic_arterial	1.08491871
55	MP0001188_hyperpigmentation	1.08222929
56	MP0010678_abnormal_skin_adnexa	1.02622896
57	MP0005666_abnormal_adipose_tissue	0.99739944
58	MP0009780_abnormal_chondrocyte_physiolo	0.98958819
59	MP0002118_abnormal_lipid_homeostasis	0.98874198
60	MP0002166_altered_tumor_susceptibility	0.98169547
61	MP0001764_abnormal_homeostasis	0.92795478
62	MP0002971_abnormal_brown_adipose	0.89317136
63	MP0001849_ear_inflammation	0.88303610
64	MP0005165_increased_susceptibility_to	0.86506261
65	MP0000467_abnormal_esophagus_morphology	0.86264514
66	MP0009115_abnormal_fat_cell	0.84591094
67	MP0005319_abnormal_enzyme/_coenzyme	0.83329949
68	MP0001485_abnormal_pinna_reflex	0.82311826
69	MP0001501_abnormal_sleep_pattern	0.82163500
70	MP0000538_abnormal_urinary_bladder	0.77836432
71	MP0003724_increased_susceptibility_to	0.77791863
72	MP0000609_abnormal_liver_physiology	0.77783853
73	MP0004858_abnormal_nervous_system	0.76602116
74	MP0005448_abnormal_energy_balance	0.75791816
75	MP0000516_abnormal_urinary_system	0.75577516
76	MP0005367_renal/urinary_system_phenotyp	0.75577516
77	MP0003300_gastrointestinal_ulcer	0.74506827
78	MP0003283_abnormal_digestive_organ	0.73934209
79	MP0001216_abnormal_epidermal_layer	0.69816005
80	MP0003453_abnormal_keratinocyte_physiol	0.68735339
81	MP0005584_abnormal_enzyme/coenzyme_acti	0.68260519
82	MP0008872_abnormal_physiological_respon	0.67351159
83	MP0001845_abnormal_inflammatory_respons	0.62637301
84	MP0002006_tumorigenesis	0.62077625
85	MP0003953_abnormal_hormone_level	0.60980971
86	MP0004947_skin_inflammation	0.58309084
87	MP0002896_abnormal_bone_mineralization	0.58080104
88	MP0009642_abnormal_blood_homeostasis	0.56545098
89	MP0000377_abnormal_hair_follicle	0.54270181
90	MP0009785_altered_susceptibility_to	0.53638910
91	MP0003315_abnormal_perineum_morphology	0.53197661
92	MP0002132_abnormal_respiratory_system	0.51490590
93	MP0005535_abnormal_body_temperature	0.51191474
94	MP0004484_altered_response_of	0.51167470
95	MP0003045_fibrosis	0.48688334
96	MP0002078_abnormal_glucose_homeostasis	0.48510555
97	MP0005275_abnormal_skin_tensile	0.48322768
98	MP0000681_abnormal_thyroid_gland	0.46789021
99	MP0003303_peritoneal_inflammation	0.46274185
100	MP0003693_abnormal_embryo_hatching	0.45267131

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperactive renin-angiotensin system (HP:0000841)	9.21623370
2	Decreased circulating renin level (HP:0003351)	6.84767425
3	Metabolic alkalosis (HP:0200114)	6.61198667
4	Abnormality of renin-angiotensin system (HP:0000847)	6.31507706
5	Abnormality of glutamine family amino acid metabolism (HP:0010902)	5.60472479
6	Abnormality of chloride homeostasis (HP:0011422)	4.96312080
7	Alkalosis (HP:0001948)	4.80754190
8	Malnutrition (HP:0004395)	4.70214958
9	Hyperaldosteronism (HP:0000859)	4.65369351
10	Flat acetabular roof (HP:0003180)	4.55050243
11	Abnormality of the vitamin B12 metabolism (HP:0004341)	4.53181062
12	Right ventricular cardiomyopathy (HP:0011663)	4.46331672
13	Abnormality of vitamin B metabolism (HP:0004340)	4.35527873
14	Ileus (HP:0002595)	3.96175739
15	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.93484446
16	Hyponatremia (HP:0002902)	3.87122697
17	Abnormality of vitamin metabolism (HP:0100508)	3.75999336
18	Abdominal distention (HP:0003270)	3.67240926
19	Intrahepatic cholestasis (HP:0001406)	3.51943406
20	Hydroxyprolinuria (HP:0003080)	3.44542839
21	Abnormality of proline metabolism (HP:0010907)	3.44542839
22	Hypokalemia (HP:0002900)	3.40773426
23	Hyperkalemia (HP:0002153)	3.40242618
24	Abnormality of potassium homeostasis (HP:0011042)	3.33156344
25	Fat malabsorption (HP:0002630)	3.26929290
26	Congenital sensorineural hearing impairment (HP:0008527)	3.26373015
27	Chronic diarrhea (HP:0002028)	3.17858012
28	Villous atrophy (HP:0011473)	3.16260457
29	Abnormality of small intestinal villus morphology (HP:0011472)	3.16260457
30	Hemorrhage of the eye (HP:0011885)	3.08860040
31	Flattened epiphyses (HP:0003071)	2.93270373
32	Conjugated hyperbilirubinemia (HP:0002908)	2.93176156
33	Abnormality of sodium homeostasis (HP:0010931)	2.91006569
34	Abnormal tarsal ossification (HP:0008369)	2.86447143
35	Abnormality of the distal phalanx of the thumb (HP:0009617)	2.83726347
36	Hyperparathyroidism (HP:0000843)	2.80611006
37	Widely patent fontanelles and sutures (HP:0004492)	2.78121565
38	Adrenal overactivity (HP:0002717)	2.70694501
39	Dehydration (HP:0001944)	2.67308533
40	Focal segmental glomerulosclerosis (HP:0000097)	2.65313682
41	Neonatal short-limb short stature (HP:0008921)	2.64974188
42	Pili torti (HP:0003777)	2.64961838
43	Hypotension (HP:0002615)	2.58873459
44	Hyperammonemia (HP:0001987)	2.54091358
45	Thin bony cortex (HP:0002753)	2.52827017
46	Abnormal biliary tract morphology (HP:0012440)	2.48701248
47	Syncope (HP:0001279)	2.48580171
48	Acanthocytosis (HP:0001927)	2.47457069
49	Chronic bronchitis (HP:0004469)	2.46981133
50	Eczematoid dermatitis (HP:0000976)	2.45067480
51	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.40947060
52	Dicarboxylic aciduria (HP:0003215)	2.40947060
53	Megaloblastic anemia (HP:0001889)	2.38490997
54	Systemic lupus erythematosus (HP:0002725)	2.37070598
55	Abnormality of the nasal mucosa (HP:0000433)	2.35454528
56	Hyperuricemia (HP:0002149)	2.34771002
57	Increased purine levels (HP:0004368)	2.34771002
58	Ventricular fibrillation (HP:0001663)	2.33587190
59	Glomerulosclerosis (HP:0000096)	2.28031857
60	Pigmentary retinal degeneration (HP:0001146)	2.25632490
61	Visceral angiomatosis (HP:0100761)	2.24768060
62	Flat capital femoral epiphysis (HP:0003370)	2.18324985
63	Glycosuria (HP:0003076)	2.18075276
64	Abnormality of urine glucose concentration (HP:0011016)	2.18075276
65	Confusion (HP:0001289)	2.11552768
66	Abnormality of carpal bone ossification (HP:0006257)	2.10527754
67	Wide cranial sutures (HP:0010537)	2.08516196
68	Renal tubular acidosis (HP:0001947)	2.06100436
69	Abnormal hair laboratory examination (HP:0003328)	2.04880448
70	Renal salt wasting (HP:0000127)	2.01990357
71	Symptomatic seizures (HP:0011145)	2.01534274
72	Spinal cord compression (HP:0002176)	1.99187359
73	Hypobetalipoproteinemia (HP:0003563)	1.97525851
74	Curly hair (HP:0002212)	1.97419592
75	Cone-rod dystrophy (HP:0000548)	1.92445075
76	Nasal polyposis (HP:0100582)	1.91520009
77	Hemangiomatosis (HP:0007461)	1.91326836
78	Metabolic acidosis (HP:0001942)	1.90958535
79	Abnormality of purine metabolism (HP:0004352)	1.90498408
80	Growth hormone excess (HP:0000845)	1.87674355
81	Palpitations (HP:0001962)	1.87548057
82	Hyperphosphatemia (HP:0002905)	1.87523020
83	Gout (HP:0001997)	1.87300980
84	Protuberant abdomen (HP:0001538)	1.86873691
85	Proximal tubulopathy (HP:0000114)	1.86712328
86	Late onset (HP:0003584)	1.84938265
87	Subcapsular cataract (HP:0000523)	1.84749628
88	Ankle clonus (HP:0011448)	1.79978567
89	Cerebral palsy (HP:0100021)	1.77864196
90	Abnormality of the costochondral junction (HP:0000919)	1.76726846
91	Nephrolithiasis (HP:0000787)	1.75719000
92	Abnormal hand bone ossification (HP:0010660)	1.75668210
93	Abnormality of nucleobase metabolism (HP:0010932)	1.73983337
94	Abnormal foot bone ossification (HP:0010675)	1.71724667
95	Xanthomatosis (HP:0000991)	1.71295417
96	Amelogenesis imperfecta (HP:0000705)	1.70647069
97	Enlarged epiphyses (HP:0010580)	1.69792976
98	Abnormality of the 1st metacarpal (HP:0010009)	1.68517991
99	Vertebral clefting (HP:0008428)	1.68307989
100	Abnormal ossification of hand bones (HP:0005921)	1.64342713

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST1R	6.03791817
2	EPHA2	5.26865898
3	ACVR1B	5.08199857
4	PIK3CA	4.63054261
5	RIPK1	4.41220979
6	LMTK2	3.51331428
7	ERN1	2.92804659
8	STK39	2.78924745
9	PRKG2	2.65241757
10	MAP3K10	2.55139182
11	EPHA3	2.26498534
12	MET	2.25404272
13	EPHB2	2.16612280
14	MAP3K2	1.79267683
15	OXSR1	1.75742498
16	MYLK	1.65093605
17	PTK6	1.60564461
18	FGFR4	1.48322785
19	TESK1	1.47482006
20	MST4	1.36047805
21	EPHB1	1.34062037
22	STK24	1.30858626
23	MAP3K12	1.27478116
24	PIK3CG	1.23075456
25	FGFR3	1.10761202
26	MAP3K1	1.05062539
27	NEK1	1.03869170
28	FER	0.99941495
29	PDPK1	0.98328041
30	DDR2	0.93358586
31	MAP2K2	0.92661854
32	AKT3	0.88362811
33	TAOK1	0.85392756
34	DYRK1B	0.84221645
35	PIM2	0.82210939
36	WNK4	0.81633771
37	PINK1	0.80281536
38	NLK	0.76371342
39	TESK2	0.75772434
40	INSRR	0.70832504
41	PRKAA2	0.69138268
42	PDK1	0.66342356
43	ERBB2	0.66302996
44	MATK	0.65237749
45	MAPK15	0.64850298
46	PRPF4B	0.63229328
47	CAMK2D	0.61740593
48	DMPK	0.59993913
49	MAPK11	0.58401247
50	GRK6	0.58373407
51	CDC42BPA	0.56652500
52	IRAK1	0.54320377
53	TNIK	0.52562554
54	STK38	0.52430826
55	MAP3K3	0.52176308
56	LATS1	0.51395482
57	MAP2K6	0.50888721
58	PTK2	0.50056365
59	PDK2	0.48883444
60	STK38L	0.47587209
61	NME1	0.46927235
62	TRIB3	0.46752996
63	PAK4	0.44232648
64	RPS6KA2	0.42847399
65	TYK2	0.42378942
66	KSR2	0.39889866
67	NEK6	0.38890028
68	ZAP70	0.37836260
69	PRKACG	0.35407790
70	PLK4	0.35357205
71	RET	0.34410160
72	RIPK4	0.33142917
73	PRKCA	0.32322823
74	ABL2	0.31822724
75	MAPKAPK2	0.31381585
76	SGK223	0.30721656
77	SGK494	0.30721656
78	MAP2K1	0.29817195
79	CSNK1A1	0.29470431
80	SRC	0.29319637
81	MAPKAPK3	0.29259741
82	SMG1	0.29196921
83	PRKCI	0.28551624
84	EEF2K	0.24866958
85	RPS6KB1	0.23520548
86	DAPK3	0.21749912
87	GRK1	0.20309179
88	SGK3	0.19754536
89	PRKCZ	0.17185045
90	CSK	0.16439525
91	JAK2	0.15935789
92	ROCK1	0.15798678
93	TBK1	0.15678252
94	LRRK2	0.14163218
95	IRAK3	0.13344705
96	PRKCD	0.11767127
97	MAP3K11	0.11450551
98	TYRO3	0.11301447
99	SGK2	0.11166728
100	CASK	0.11155115

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.92030731
2	Sulfur metabolism_Homo sapiens_hsa00920	3.91331221
3	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	3.28711700
4	Fat digestion and absorption_Homo sapiens_hsa04975	3.23175929
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.91518796
6	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.88062054
7	Caffeine metabolism_Homo sapiens_hsa00232	2.78889361
8	Mineral absorption_Homo sapiens_hsa04978	2.74590143
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.65173883
10	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.63319437
11	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.43771321
12	Renin-angiotensin system_Homo sapiens_hsa04614	2.17918248
13	Histidine metabolism_Homo sapiens_hsa00340	2.17915131
14	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.16517107
15	Chemical carcinogenesis_Homo sapiens_hsa05204	2.15112399
16	Retinol metabolism_Homo sapiens_hsa00830	2.13580230
17	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.11642658
18	Arginine biosynthesis_Homo sapiens_hsa00220	2.06547986
19	Starch and sucrose metabolism_Homo sapiens_hsa00500	2.05026817
20	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.98747517
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.96503903
22	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.93778420
23	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.82986757
24	Bile secretion_Homo sapiens_hsa04976	1.74336454
25	Fatty acid degradation_Homo sapiens_hsa00071	1.71956514
26	PPAR signaling pathway_Homo sapiens_hsa03320	1.65907867
27	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.49953793
28	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.48509735
29	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.48344571
30	Protein digestion and absorption_Homo sapiens_hsa04974	1.48265227
31	Pancreatic secretion_Homo sapiens_hsa04972	1.40891659
32	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.36821421
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.32447815
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.27473946
35	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.19610836
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.17402135
37	Arginine and proline metabolism_Homo sapiens_hsa00330	1.09448043
38	Galactose metabolism_Homo sapiens_hsa00052	1.08808648
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.04964183
40	Glycerolipid metabolism_Homo sapiens_hsa00561	1.03863187
41	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.98916183
42	Phenylalanine metabolism_Homo sapiens_hsa00360	0.97357699
43	Tryptophan metabolism_Homo sapiens_hsa00380	0.96375376
44	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.92432892
45	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.92001781
46	Glutathione metabolism_Homo sapiens_hsa00480	0.86063567
47	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.84276509
48	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.80684250
49	Sulfur relay system_Homo sapiens_hsa04122	0.78262909
50	Butanoate metabolism_Homo sapiens_hsa00650	0.74072044
51	Tight junction_Homo sapiens_hsa04530	0.73174935
52	Tyrosine metabolism_Homo sapiens_hsa00350	0.69995520
53	Fatty acid metabolism_Homo sapiens_hsa01212	0.68041096
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.66885368
55	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.60670549
56	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.60614211
57	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.60029870
58	Sphingolipid metabolism_Homo sapiens_hsa00600	0.59462204
59	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.57962884
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.57942213
61	Propanoate metabolism_Homo sapiens_hsa00640	0.57324520
62	Peroxisome_Homo sapiens_hsa04146	0.56968918
63	Renin secretion_Homo sapiens_hsa04924	0.55553659
64	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.53136343
65	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.51710637
66	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.51226137
67	Hepatitis C_Homo sapiens_hsa05160	0.50202231
68	Other glycan degradation_Homo sapiens_hsa00511	0.46268332
69	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.44130197
70	Asthma_Homo sapiens_hsa05310	0.37992824
71	Gastric acid secretion_Homo sapiens_hsa04971	0.37768548
72	Insulin resistance_Homo sapiens_hsa04931	0.34487367
73	Carbon metabolism_Homo sapiens_hsa01200	0.28703600
74	Pyruvate metabolism_Homo sapiens_hsa00620	0.28509774
75	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.28224078
76	Metabolic pathways_Homo sapiens_hsa01100	0.26376680
77	Folate biosynthesis_Homo sapiens_hsa00790	0.24713031
78	ABC transporters_Homo sapiens_hsa02010	0.20208592
79	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.17118643
80	Vibrio cholerae infection_Homo sapiens_hsa05110	0.16071577
81	Allograft rejection_Homo sapiens_hsa05330	0.14493225
82	Salivary secretion_Homo sapiens_hsa04970	0.13002958
83	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.12068312
84	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.12040530
85	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.12011805
86	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.11899132
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.11656963
88	Type I diabetes mellitus_Homo sapiens_hsa04940	0.11623069
89	Glucagon signaling pathway_Homo sapiens_hsa04922	0.11261072
90	Insulin secretion_Homo sapiens_hsa04911	0.09520376
91	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.09213032
92	Cocaine addiction_Homo sapiens_hsa05030	0.07816470
93	Graft-versus-host disease_Homo sapiens_hsa05332	0.06920982
94	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.06307168
95	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.04734181
96	Pertussis_Homo sapiens_hsa05133	0.03732653
97	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.03624245
98	Adherens junction_Homo sapiens_hsa04520	0.01649776
99	AMPK signaling pathway_Homo sapiens_hsa04152	0.01392393
100	Choline metabolism in cancer_Homo sapiens_hsa05231	0.01390333

LINC00675

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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