ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	indolalkylamine metabolic process (GO:0006586)	4.92738174
2	DNA double-strand break processing (GO:0000729)	4.27228409
3	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.23645548
4	tryptophan catabolic process (GO:0006569)	4.16480471
5	indole-containing compound catabolic process (GO:0042436)	4.16480471
6	indolalkylamine catabolic process (GO:0046218)	4.16480471
7	signal peptide processing (GO:0006465)	3.91854729
8	cellular ketone body metabolic process (GO:0046950)	3.84160427
9	neural tube formation (GO:0001841)	3.80198507
10	monoubiquitinated protein deubiquitination (GO:0035520)	3.78105092
11	tryptophan metabolic process (GO:0006568)	3.77292886
12	photoreceptor cell maintenance (GO:0045494)	3.68713735
13	cilium or flagellum-dependent cell motility (GO:0001539)	3.67123402
14	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.59028212
15	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.58360994
16	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.58360994
17	regulation of translation, ncRNA-mediated (GO:0045974)	3.58360994
18	behavioral response to nicotine (GO:0035095)	3.57918704
19	kynurenine metabolic process (GO:0070189)	3.53113786
20	regulation of hippo signaling (GO:0035330)	3.49289035
21	ketone body metabolic process (GO:1902224)	3.47486098
22	peptidyl-histidine modification (GO:0018202)	3.46394050
23	indole-containing compound metabolic process (GO:0042430)	3.44630823
24	detection of light stimulus involved in sensory perception (GO:0050962)	3.43781395
25	detection of light stimulus involved in visual perception (GO:0050908)	3.43781395
26	interkinetic nuclear migration (GO:0022027)	3.43301297
27	recombinational repair (GO:0000725)	3.35569096
28	double-strand break repair via homologous recombination (GO:0000724)	3.35318216
29	tachykinin receptor signaling pathway (GO:0007217)	3.33611131
30	reflex (GO:0060004)	3.30266649
31	positive regulation of developmental pigmentation (GO:0048087)	3.28511848
32	regulation of pigment cell differentiation (GO:0050932)	3.25913656
33	protein K11-linked deubiquitination (GO:0035871)	3.25698270
34	replication fork processing (GO:0031297)	3.18217103
35	auditory receptor cell stereocilium organization (GO:0060088)	3.14534743
36	retinal cone cell development (GO:0046549)	3.11676523
37	snRNA transcription (GO:0009301)	3.11305227
38	oxidative demethylation (GO:0070989)	3.03001972
39	L-methionine salvage (GO:0071267)	3.02808634
40	L-methionine biosynthetic process (GO:0071265)	3.02808634
41	amino acid salvage (GO:0043102)	3.02808634
42	mannosylation (GO:0097502)	2.99199569
43	preassembly of GPI anchor in ER membrane (GO:0016254)	2.99142927
44	negative regulation of mast cell activation (GO:0033004)	2.98433679
45	protein K48-linked deubiquitination (GO:0071108)	2.95068304
46	behavioral response to ethanol (GO:0048149)	2.94999874
47	protein prenylation (GO:0018342)	2.93468221
48	prenylation (GO:0097354)	2.93468221
49	microtubule anchoring (GO:0034453)	2.87459314
50	sulfation (GO:0051923)	2.86880707
51	cellular biogenic amine catabolic process (GO:0042402)	2.86849383
52	amine catabolic process (GO:0009310)	2.86849383
53	synapsis (GO:0007129)	2.86071327
54	methionine biosynthetic process (GO:0009086)	2.82793066
55	reciprocal meiotic recombination (GO:0007131)	2.82570955
56	reciprocal DNA recombination (GO:0035825)	2.82570955
57	L-fucose catabolic process (GO:0042355)	2.81832369
58	fucose catabolic process (GO:0019317)	2.81832369
59	L-fucose metabolic process (GO:0042354)	2.81832369
60	establishment of protein localization to Golgi (GO:0072600)	2.81295961
61	cilium organization (GO:0044782)	2.78913419
62	piRNA metabolic process (GO:0034587)	2.78441946
63	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.78222559
64	protein K63-linked deubiquitination (GO:0070536)	2.78094159
65	serotonin metabolic process (GO:0042428)	2.77637774
66	regulation of gene silencing by RNA (GO:0060966)	2.76913232
67	regulation of posttranscriptional gene silencing (GO:0060147)	2.76913232
68	regulation of gene silencing by miRNA (GO:0060964)	2.76913232
69	cilium morphogenesis (GO:0060271)	2.75765314
70	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.75004978
71	cilium assembly (GO:0042384)	2.72606964
72	centriole replication (GO:0007099)	2.72141293
73	adenosine metabolic process (GO:0046085)	2.72004851
74	epithelial cilium movement (GO:0003351)	2.70711329
75	DNA methylation involved in gamete generation (GO:0043046)	2.64926292
76	protein polyglutamylation (GO:0018095)	2.64223880
77	inner ear receptor stereocilium organization (GO:0060122)	2.63880472
78	multicellular organism reproduction (GO:0032504)	2.63613068
79	benzene-containing compound metabolic process (GO:0042537)	2.61538735
80	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.59867118
81	DNA integration (GO:0015074)	2.59564547
82	response to nitrosative stress (GO:0051409)	2.59184917
83	axoneme assembly (GO:0035082)	2.57917356
84	regulation of sarcomere organization (GO:0060297)	2.56620396
85	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.56040780
86	dopamine transport (GO:0015872)	2.53475775
87	intraciliary transport (GO:0042073)	2.53066958
88	neuronal action potential (GO:0019228)	2.51693330
89	cilium movement (GO:0003341)	2.50550809
90	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.50111633
91	platelet dense granule organization (GO:0060155)	2.49970035
92	central nervous system neuron axonogenesis (GO:0021955)	2.49330668
93	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.48654648
94	histone H3-K9 methylation (GO:0051567)	2.48437407
95	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.48112520
96	response to pheromone (GO:0019236)	2.48098418
97	rhodopsin mediated signaling pathway (GO:0016056)	2.45660735
98	gamma-aminobutyric acid transport (GO:0015812)	2.45406693
99	DNA demethylation (GO:0080111)	2.43941819
100	male meiosis I (GO:0007141)	2.43860208

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.54387522
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.53431189
3	VDR_22108803_ChIP-Seq_LS180_Human	3.22212640
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.17583817
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.93765104
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.70405846
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.65315696
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.57868402
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.48825365
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.48227657
11	EWS_26573619_Chip-Seq_HEK293_Human	2.34479288
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.32771061
13	FUS_26573619_Chip-Seq_HEK293_Human	2.27152233
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15074920
15	P300_19829295_ChIP-Seq_ESCs_Human	2.14522503
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.09011372
17	ER_23166858_ChIP-Seq_MCF-7_Human	2.08794828
18	EZH2_22144423_ChIP-Seq_EOC_Human	2.07691099
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.06595525
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.02837596
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.98902698
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.94393681
23	STAT3_23295773_ChIP-Seq_U87_Human	1.84952392
24	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.82015242
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.78123126
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.77556164
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.75271791
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.67176221
29	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.66906096
30	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.65283793
31	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.64614500
32	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.63401906
33	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.62260652
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.61282935
35	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.58884041
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.58837912
37	TCF4_23295773_ChIP-Seq_U87_Human	1.55776841
38	AR_21572438_ChIP-Seq_LNCaP_Human	1.55700019
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.53918563
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53918563
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.48125587
42	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.45681801
43	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.45347316
44	AR_25329375_ChIP-Seq_VCAP_Human	1.43730452
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43635481
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.41436410
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40606956
48	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34679355
49	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.33940129
50	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.33783752
51	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33534379
52	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.32839376
53	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.31612349
54	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31295643
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30938915
56	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30938915
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.29321752
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.29202074
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29194111
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29194111
61	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28770499
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.28600136
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26999998
64	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.23937873
65	ELK1_19687146_ChIP-ChIP_HELA_Human	1.21804591
66	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.21137329
67	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.20439761
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.19489195
69	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.18938980
70	CDX2_22108803_ChIP-Seq_LS180_Human	1.14676248
71	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.13680336
72	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.12566473
73	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.12139917
74	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.10817139
75	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.10229501
76	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.09680259
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08794403
78	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.08609310
79	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07967743
80	TP53_16413492_ChIP-PET_HCT116_Human	1.05555823
81	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.05215034
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.05215034
83	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.04944090
84	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04433173
85	MYC_18940864_ChIP-ChIP_HL60_Human	1.03890661
86	AR_20517297_ChIP-Seq_VCAP_Human	1.03790846
87	VDR_23849224_ChIP-Seq_CD4+_Human	1.03066925
88	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02793039
89	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01383000
90	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.01262070
91	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.99030838
92	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98546154
93	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98217791
94	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.97728753
95	JUN_21703547_ChIP-Seq_K562_Human	0.96421655
96	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.95569837
97	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.94953970
98	NCOR_22424771_ChIP-Seq_293T_Human	0.94761089
99	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.94382706
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.93551589

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.55427059
2	MP0008057_abnormal_DNA_replication	3.44394211
3	MP0003195_calcinosis	2.44923297
4	MP0005551_abnormal_eye_electrophysiolog	2.43792614
5	MP0002102_abnormal_ear_morphology	2.40378716
6	MP0008877_abnormal_DNA_methylation	2.35933212
7	MP0003136_yellow_coat_color	2.24703925
8	MP0002736_abnormal_nociception_after	2.24147531
9	MP0005253_abnormal_eye_physiology	2.22265206
10	MP0008058_abnormal_DNA_repair	2.18116805
11	MP0006072_abnormal_retinal_apoptosis	2.18026240
12	MP0000372_irregular_coat_pigmentation	2.12711958
13	MP0001968_abnormal_touch/_nociception	2.07923296
14	MP0005174_abnormal_tail_pigmentation	2.07010514
15	MP0010094_abnormal_chromosome_stability	1.97887516
16	MP0003718_maternal_effect	1.95762900
17	MP0009046_muscle_twitch	1.90247424
18	MP0006292_abnormal_olfactory_placode	1.87704957
19	MP0003646_muscle_fatigue	1.85934230
20	MP0005646_abnormal_pituitary_gland	1.84924166
21	MP0001501_abnormal_sleep_pattern	1.74817458
22	MP0005645_abnormal_hypothalamus_physiol	1.72654365
23	MP0000427_abnormal_hair_cycle	1.72184130
24	MP0008872_abnormal_physiological_respon	1.71895255
25	MP0002938_white_spotting	1.67212685
26	MP0001986_abnormal_taste_sensitivity	1.61410665
27	MP0003950_abnormal_plasma_membrane	1.54726719
28	MP0006276_abnormal_autonomic_nervous	1.49335543
29	MP0005083_abnormal_biliary_tract	1.43914243
30	MP0005075_abnormal_melanosome_morpholog	1.43908056
31	MP0002095_abnormal_skin_pigmentation	1.43633864
32	MP0010386_abnormal_urinary_bladder	1.41996132
33	MP0001529_abnormal_vocalization	1.41842392
34	MP0002837_dystrophic_cardiac_calcinosis	1.40600741
35	MP0002876_abnormal_thyroid_physiology	1.38232452
36	MP0000631_abnormal_neuroendocrine_gland	1.36146516
37	MP0002638_abnormal_pupillary_reflex	1.33526278
38	MP0001486_abnormal_startle_reflex	1.31938547
39	MP0004147_increased_porphyrin_level	1.30363633
40	MP0005410_abnormal_fertilization	1.29831911
41	MP0002928_abnormal_bile_duct	1.29598601
42	MP0001984_abnormal_olfaction	1.28015762
43	MP0003880_abnormal_central_pattern	1.27486575
44	MP0005171_absent_coat_pigmentation	1.27341924
45	MP0009745_abnormal_behavioral_response	1.26587051
46	MP0005084_abnormal_gallbladder_morpholo	1.26171319
47	MP0000015_abnormal_ear_pigmentation	1.25608092
48	MP0001485_abnormal_pinna_reflex	1.23305734
49	MP0001764_abnormal_homeostasis	1.23232876
50	MP0004043_abnormal_pH_regulation	1.22603435
51	MP0002160_abnormal_reproductive_system	1.19580735
52	MP0003698_abnormal_male_reproductive	1.18921723
53	MP0002735_abnormal_chemical_nociception	1.18619740
54	MP0002138_abnormal_hepatobiliary_system	1.18592406
55	MP0001929_abnormal_gametogenesis	1.17651008
56	MP0008995_early_reproductive_senescence	1.11514610
57	MP0004142_abnormal_muscle_tone	1.11272228
58	MP0004145_abnormal_muscle_electrophysio	1.10745109
59	MP0009697_abnormal_copulation	1.10542882
60	MP0002272_abnormal_nervous_system	1.09814973
61	MP0003787_abnormal_imprinting	1.09806176
62	MP0000383_abnormal_hair_follicle	1.05947102
63	MP0004215_abnormal_myocardial_fiber	1.04598481
64	MP0005187_abnormal_penis_morphology	1.03833790
65	MP0003252_abnormal_bile_duct	1.03273851
66	MP0002234_abnormal_pharynx_morphology	1.00429910
67	MP0004924_abnormal_behavior	0.99202184
68	MP0005386_behavior/neurological_phenoty	0.99202184
69	MP0002067_abnormal_sensory_capabilities	0.98200019
70	MP0005395_other_phenotype	0.97878720
71	MP0005670_abnormal_white_adipose	0.96379660
72	MP0005085_abnormal_gallbladder_physiolo	0.95491952
73	MP0000538_abnormal_urinary_bladder	0.94591781
74	MP0003011_delayed_dark_adaptation	0.94482157
75	MP0000230_abnormal_systemic_arterial	0.94113846
76	MP0002572_abnormal_emotion/affect_behav	0.93141345
77	MP0002210_abnormal_sex_determination	0.91802161
78	MP0005389_reproductive_system_phenotype	0.91539975
79	MP0005266_abnormal_metabolism	0.90220544
80	MP0003786_premature_aging	0.88975922
81	MP0005391_vision/eye_phenotype	0.88771419
82	MP0003943_abnormal_hepatobiliary_system	0.86688132
83	MP0001970_abnormal_pain_threshold	0.86412668
84	MP0000653_abnormal_sex_gland	0.86313145
85	MP0008775_abnormal_heart_ventricle	0.86017643
86	MP0001324_abnormal_eye_pigmentation	0.83942597
87	MP0008789_abnormal_olfactory_epithelium	0.80168192
88	MP0005195_abnormal_posterior_eye	0.79476475
89	MP0002557_abnormal_social/conspecific_i	0.78444920
90	MP0002751_abnormal_autonomic_nervous	0.76418083
91	MP0001145_abnormal_male_reproductive	0.76149973
92	MP0002733_abnormal_thermal_nociception	0.73349999
93	MP0002132_abnormal_respiratory_system	0.72975744
94	MP0000647_abnormal_sebaceous_gland	0.72711528
95	MP0008875_abnormal_xenobiotic_pharmacok	0.71492380
96	MP0004885_abnormal_endolymph	0.71326112
97	MP0002229_neurodegeneration	0.70753289
98	MP0002752_abnormal_somatic_nervous	0.70659372
99	MP0003635_abnormal_synaptic_transmissio	0.70211639
100	MP0005397_hematopoietic_system_phenotyp	0.70047829

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.23643555
2	Pancreatic fibrosis (HP:0100732)	3.85408336
3	True hermaphroditism (HP:0010459)	3.76974494
4	Molar tooth sign on MRI (HP:0002419)	3.69784198
5	Abnormality of midbrain morphology (HP:0002418)	3.69784198
6	Gaze-evoked nystagmus (HP:0000640)	3.44469163
7	Hyperventilation (HP:0002883)	3.37924730
8	Attenuation of retinal blood vessels (HP:0007843)	3.35562337
9	Type II lissencephaly (HP:0007260)	3.11202104
10	Medial flaring of the eyebrow (HP:0010747)	3.04053501
11	Chronic hepatic failure (HP:0100626)	2.94940215
12	Nephronophthisis (HP:0000090)	2.90571767
13	Genetic anticipation (HP:0003743)	2.87656017
14	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.82645822
15	Cerebellar dysplasia (HP:0007033)	2.81626440
16	Congenital stationary night blindness (HP:0007642)	2.78695913
17	Abnormality of the renal cortex (HP:0011035)	2.74625003
18	Abnormality of the renal medulla (HP:0100957)	2.72701946
19	Cystic liver disease (HP:0006706)	2.72585038
20	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.60598767
21	Progressive cerebellar ataxia (HP:0002073)	2.60379942
22	Abnormal biliary tract physiology (HP:0012439)	2.56168867
23	Bile duct proliferation (HP:0001408)	2.56168867
24	Protruding tongue (HP:0010808)	2.54888077
25	Clumsiness (HP:0002312)	2.52280150
26	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.51272329
27	Absent speech (HP:0001344)	2.50598448
28	Febrile seizures (HP:0002373)	2.46441989
29	Abolished electroretinogram (ERG) (HP:0000550)	2.45511975
30	Bony spicule pigmentary retinopathy (HP:0007737)	2.44713276
31	Abnormal protein glycosylation (HP:0012346)	2.40990357
32	Abnormal glycosylation (HP:0012345)	2.40990357
33	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.40990357
34	Abnormal protein N-linked glycosylation (HP:0012347)	2.40990357
35	Congenital primary aphakia (HP:0007707)	2.39081102
36	Gait imbalance (HP:0002141)	2.37495067
37	Thyroiditis (HP:0100646)	2.28753751
38	Abnormality of B cell number (HP:0010975)	2.26179925
39	Tubulointerstitial nephritis (HP:0001970)	2.25856206
40	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.24139096
41	Inability to walk (HP:0002540)	2.23843881
42	Sloping forehead (HP:0000340)	2.20913121
43	Retinal dysplasia (HP:0007973)	2.19791388
44	Chromsome breakage (HP:0040012)	2.19191260
45	Central scotoma (HP:0000603)	2.17475960
46	Nephrogenic diabetes insipidus (HP:0009806)	2.17359968
47	Lissencephaly (HP:0001339)	2.15542325
48	Renal cortical cysts (HP:0000803)	2.12723707
49	Abnormality of the ileum (HP:0001549)	2.12600372
50	Abnormality of chromosome stability (HP:0003220)	2.12365188
51	Hypoplasia of the pons (HP:0012110)	2.11193250
52	Panhypogammaglobulinemia (HP:0003139)	2.10577933
53	Hypothermia (HP:0002045)	2.09994161
54	Progressive inability to walk (HP:0002505)	2.09231574
55	Abnormality of the pons (HP:0007361)	2.08874258
56	Decreased central vision (HP:0007663)	2.08547533
57	Type I transferrin isoform profile (HP:0003642)	2.08145773
58	Genital tract atresia (HP:0001827)	2.08097547
59	Sclerocornea (HP:0000647)	2.07780494
60	Ectopic kidney (HP:0000086)	2.07247264
61	Anencephaly (HP:0002323)	2.04092500
62	Astigmatism (HP:0000483)	2.03129081
63	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.02880427
64	Meckel diverticulum (HP:0002245)	2.02379762
65	Congenital hepatic fibrosis (HP:0002612)	2.02302280
66	Fair hair (HP:0002286)	2.02243912
67	Furrowed tongue (HP:0000221)	2.01674537
68	Congenital sensorineural hearing impairment (HP:0008527)	2.00149780
69	Abnormality of DNA repair (HP:0003254)	1.99241379
70	Clubbing of toes (HP:0100760)	1.98885400
71	Male pseudohermaphroditism (HP:0000037)	1.98333828
72	Postaxial foot polydactyly (HP:0001830)	1.95747560
73	Increased corneal curvature (HP:0100692)	1.95605099
74	Keratoconus (HP:0000563)	1.95605099
75	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.95108458
76	Absent/shortened dynein arms (HP:0200106)	1.95108458
77	Small hand (HP:0200055)	1.93762428
78	Constricted visual fields (HP:0001133)	1.93669913
79	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.93191224
80	Abnormality of alanine metabolism (HP:0010916)	1.93191224
81	Hyperalaninemia (HP:0003348)	1.93191224
82	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.93010756
83	Vaginal atresia (HP:0000148)	1.92548040
84	Hypoproteinemia (HP:0003075)	1.91755750
85	Poor coordination (HP:0002370)	1.90742469
86	Broad-based gait (HP:0002136)	1.90567044
87	Widely spaced teeth (HP:0000687)	1.89371928
88	Abnormal ciliary motility (HP:0012262)	1.89296910
89	Large for gestational age (HP:0001520)	1.86696578
90	Volvulus (HP:0002580)	1.86233465
91	Stomach cancer (HP:0012126)	1.85958347
92	Ketosis (HP:0001946)	1.84190119
93	Dialeptic seizures (HP:0011146)	1.83507153
94	Abnormal rod and cone electroretinograms (HP:0008323)	1.83133144
95	Atonic seizures (HP:0010819)	1.82242324
96	Colon cancer (HP:0003003)	1.81110917
97	Preaxial hand polydactyly (HP:0001177)	1.80539062
98	Abnormality of the renal collecting system (HP:0004742)	1.78409787
99	Birth length less than 3rd percentile (HP:0003561)	1.77212749
100	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.76981432

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.15150372
2	BMPR1B	3.83842552
3	ZAK	2.79831906
4	ACVR1B	2.73058691
5	MAP4K2	2.72508700
6	ADRBK2	2.44003103
7	NUAK1	2.38583160
8	INSRR	2.11483650
9	WNK3	1.99160371
10	PINK1	1.97421783
11	MAPK13	1.83775261
12	BRSK2	1.64922670
13	TAOK3	1.64574605
14	GRK1	1.59973223
15	MAP3K4	1.43241408
16	AKT3	1.42959748
17	PIK3CG	1.42818510
18	TEC	1.42162118
19	TGFBR1	1.40094928
20	TRIM28	1.24475406
21	TIE1	1.19474339
22	MKNK2	1.17522878
23	ADRBK1	1.14705075
24	STK38L	1.12445546
25	CASK	1.11398795
26	TNIK	1.09187144
27	MAP2K7	1.07482683
28	MARK3	1.07158179
29	EIF2AK3	1.02692935
30	LATS1	1.02362115
31	PLK2	0.93322319
32	PBK	0.92320584
33	OXSR1	0.92172537
34	WEE1	0.92122513
35	CCNB1	0.91676125
36	BCKDK	0.90509352
37	STK3	0.90123233
38	CSNK1A1L	0.88742427
39	TNK2	0.88214454
40	MST4	0.81800186
41	PTK2B	0.80728484
42	PAK3	0.80411041
43	CSNK1G1	0.79530363
44	SRPK1	0.78648656
45	PRKCE	0.78101680
46	CSNK1G3	0.76224408
47	MELK	0.71786918
48	STK39	0.71212036
49	PLK4	0.70991118
50	OBSCN	0.69701404
51	TXK	0.68880291
52	CDK3	0.67729002
53	ATR	0.67624002
54	CSNK1G2	0.66205828
55	NLK	0.65378389
56	NTRK3	0.64791561
57	FLT3	0.64740338
58	MKNK1	0.64706435
59	CDC7	0.64204239
60	MAPKAPK3	0.62526397
61	ERBB3	0.61885857
62	CAMKK2	0.60957989
63	PKN1	0.59763293
64	KIT	0.57968643
65	TLK1	0.56827432
66	VRK1	0.55487701
67	RPS6KA5	0.55410604
68	NEK2	0.54535475
69	PLK1	0.53909418
70	ATM	0.53300458
71	GRK5	0.51434769
72	CHEK2	0.50485213
73	PLK3	0.50360047
74	BCR	0.49669302
75	FER	0.47816253
76	SGK2	0.47795421
77	PRKCG	0.46881243
78	PRKCQ	0.45992349
79	IRAK1	0.45705767
80	EPHA4	0.44170125
81	MUSK	0.44060129
82	MAP3K7	0.41950734
83	NME1	0.41618494
84	CSNK1D	0.41332665
85	DYRK2	0.41176116
86	PDK2	0.38199252
87	DYRK3	0.37428436
88	IKBKB	0.36582406
89	PRKAA2	0.35221210
90	BRD4	0.34798416
91	CDK8	0.34111384
92	WNK4	0.33964957
93	CSNK1A1	0.33958432
94	DAPK2	0.33698702
95	CAMK2A	0.32495413
96	DYRK1A	0.32095503
97	PIK3CA	0.31701786
98	MARK1	0.31694326
99	PNCK	0.31025028
100	PRKAA1	0.30210091

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	3.16848187
2	Homologous recombination_Homo sapiens_hsa03440	3.11638731
3	Fanconi anemia pathway_Homo sapiens_hsa03460	2.72095775
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.56850502
5	Phototransduction_Homo sapiens_hsa04744	2.54591602
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.47020690
7	Olfactory transduction_Homo sapiens_hsa04740	2.22118512
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.15916696
9	Tryptophan metabolism_Homo sapiens_hsa00380	2.13894306
10	RNA polymerase_Homo sapiens_hsa03020	1.99194603
11	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.98289143
12	Propanoate metabolism_Homo sapiens_hsa00640	1.91820874
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.85199412
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.84133708
15	Basal transcription factors_Homo sapiens_hsa03022	1.82752313
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.82525235
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.80060130
18	ABC transporters_Homo sapiens_hsa02010	1.77347081
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.76882977
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.72085637
21	Non-homologous end-joining_Homo sapiens_hsa03450	1.71898800
22	Nicotine addiction_Homo sapiens_hsa05033	1.68546424
23	Taste transduction_Homo sapiens_hsa04742	1.57154574
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.54211349
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.40797322
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.40699170
27	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.39619559
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.37701495
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.37233205
30	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.31829678
31	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.23751569
32	Morphine addiction_Homo sapiens_hsa05032	1.18895338
33	Chemical carcinogenesis_Homo sapiens_hsa05204	1.18427228
34	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.17395513
35	beta-Alanine metabolism_Homo sapiens_hsa00410	1.16338672
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.10875191
37	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.09393287
38	Purine metabolism_Homo sapiens_hsa00230	1.08858101
39	Peroxisome_Homo sapiens_hsa04146	1.08387644
40	Lysine degradation_Homo sapiens_hsa00310	1.05679933
41	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.05009670
42	Circadian entrainment_Homo sapiens_hsa04713	1.04311904
43	Serotonergic synapse_Homo sapiens_hsa04726	1.03846206
44	Glycerolipid metabolism_Homo sapiens_hsa00561	1.03523358
45	Retinol metabolism_Homo sapiens_hsa00830	1.02199786
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.96605139
47	Mismatch repair_Homo sapiens_hsa03430	0.95951293
48	One carbon pool by folate_Homo sapiens_hsa00670	0.95668310
49	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.94383847
50	Regulation of autophagy_Homo sapiens_hsa04140	0.93976659
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.89437545
52	Salivary secretion_Homo sapiens_hsa04970	0.87864633
53	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.86300686
54	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.86104233
55	Calcium signaling pathway_Homo sapiens_hsa04020	0.84168826
56	RNA degradation_Homo sapiens_hsa03018	0.83344579
57	Pyrimidine metabolism_Homo sapiens_hsa00240	0.82585465
58	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.80772042
59	GABAergic synapse_Homo sapiens_hsa04727	0.78760250
60	Glutamatergic synapse_Homo sapiens_hsa04724	0.77595708
61	Circadian rhythm_Homo sapiens_hsa04710	0.77529455
62	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.77502376
63	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.76511015
64	Primary immunodeficiency_Homo sapiens_hsa05340	0.75887423
65	Caffeine metabolism_Homo sapiens_hsa00232	0.75849093
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.68481085
67	Fatty acid metabolism_Homo sapiens_hsa01212	0.68183043
68	Sphingolipid metabolism_Homo sapiens_hsa00600	0.66408981
69	Fatty acid degradation_Homo sapiens_hsa00071	0.64688879
70	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.63386714
71	Nucleotide excision repair_Homo sapiens_hsa03420	0.63155372
72	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.62553902
73	Insulin secretion_Homo sapiens_hsa04911	0.62001469
74	RNA transport_Homo sapiens_hsa03013	0.58975427
75	Base excision repair_Homo sapiens_hsa03410	0.57104885
76	Metabolic pathways_Homo sapiens_hsa01100	0.56967680
77	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.54089653
78	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.53433188
79	Long-term depression_Homo sapiens_hsa04730	0.53104761
80	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.52363720
81	Platelet activation_Homo sapiens_hsa04611	0.50371130
82	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.48285136
83	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.45259300
84	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.43792267
85	Oocyte meiosis_Homo sapiens_hsa04114	0.43318082
86	Glutathione metabolism_Homo sapiens_hsa00480	0.43192083
87	Steroid biosynthesis_Homo sapiens_hsa00100	0.42996887
88	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.42501823
89	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.42313962
90	Histidine metabolism_Homo sapiens_hsa00340	0.42181094
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.41524719
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.41014696
93	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.40752912
94	Renin secretion_Homo sapiens_hsa04924	0.40516828
95	Alcoholism_Homo sapiens_hsa05034	0.40077855
96	Cholinergic synapse_Homo sapiens_hsa04725	0.39914263
97	Huntingtons disease_Homo sapiens_hsa05016	0.38974910
98	Dopaminergic synapse_Homo sapiens_hsa04728	0.36977578
99	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.36648675
100	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.33565222

LINC00680

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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