ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis (GO:0007140)	9.66353017
2	acrosome reaction (GO:0007340)	8.56813649
3	regulation of oxidative stress-induced neuron death (GO:1903203)	8.27042621
4	spermatid development (GO:0007286)	8.17469045
5	sperm motility (GO:0030317)	7.54894722
6	regulation of oxidative phosphorylation (GO:0002082)	7.39772038
7	relaxation of smooth muscle (GO:0044557)	7.24710857
8	binding of sperm to zona pellucida (GO:0007339)	7.14497113
9	multicellular organism reproduction (GO:0032504)	7.06928621
10	potassium ion export (GO:0071435)	6.89588961
11	nucleosome disassembly (GO:0006337)	6.87508227
12	protein-DNA complex disassembly (GO:0032986)	6.87508227
13	motile cilium assembly (GO:0044458)	6.80550658
14	Leydig cell differentiation (GO:0033327)	6.46151771
15	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	6.34068337
16	male sex determination (GO:0030238)	6.32222432
17	axonemal dynein complex assembly (GO:0070286)	5.95724580
18	activation of protein kinase B activity (GO:0032148)	5.92659413
19	cGMP-mediated signaling (GO:0019934)	5.92257544
20	synapsis (GO:0007129)	5.88910062
21	polyamine biosynthetic process (GO:0006596)	5.83406286
22	negative regulation of response to reactive oxygen species (GO:1901032)	5.78208777
23	regulation of hydrogen peroxide-induced cell death (GO:1903205)	5.74010184
24	organic cation transport (GO:0015695)	5.68258034
25	sperm-egg recognition (GO:0035036)	5.56881070
26	cilium or flagellum-dependent cell motility (GO:0001539)	5.47899228
27	regulation of autophagic vacuole assembly (GO:2000785)	5.31470268
28	androgen biosynthetic process (GO:0006702)	5.26146011
29	regulation of dopamine secretion (GO:0014059)	5.14202041
30	epithelial cilium movement (GO:0003351)	5.12647251
31	cell-cell recognition (GO:0009988)	5.02282016
32	TOR signaling (GO:0031929)	5.02173195
33	glutamine family amino acid catabolic process (GO:0009065)	4.94553350
34	protein polymerization (GO:0051258)	4.93069005
35	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	4.89484388
36	reproduction (GO:0000003)	4.89084813
37	glycogen metabolic process (GO:0005977)	4.87249980
38	glucan metabolic process (GO:0044042)	4.82983714
39	cellular glucan metabolic process (GO:0006073)	4.82983714
40	regulation of cellular respiration (GO:0043457)	4.79993496
41	germ cell development (GO:0007281)	4.77107245
42	positive regulation of glycolytic process (GO:0045821)	4.72881454
43	tongue development (GO:0043586)	4.60938439
44	single fertilization (GO:0007338)	4.60473364
45	response to acidic pH (GO:0010447)	4.53061326
46	regulation of synaptic transmission, dopaminergic (GO:0032225)	4.44120680
47	regulation of vacuole organization (GO:0044088)	4.41863185
48	acrosome assembly (GO:0001675)	4.37112691
49	mitochondrion degradation (GO:0000422)	4.36034567
50	ventricular system development (GO:0021591)	4.33165668
51	coenzyme catabolic process (GO:0009109)	4.32710113
52	histone exchange (GO:0043486)	4.28995357
53	membrane repolarization during action potential (GO:0086011)	4.26316848
54	oogenesis (GO:0048477)	4.24615009
55	fusion of sperm to egg plasma membrane (GO:0007342)	4.17934309
56	cilium movement (GO:0003341)	4.10819156
57	positive regulation of amine transport (GO:0051954)	4.09723434
58	diacylglycerol metabolic process (GO:0046339)	4.06340156
59	cellular biogenic amine biosynthetic process (GO:0042401)	4.00540878
60	chromosome organization involved in meiosis (GO:0070192)	4.00099671
61	cellular response to toxic substance (GO:0097237)	3.99068141
62	amine biosynthetic process (GO:0009309)	3.98134520
63	aspartate family amino acid catabolic process (GO:0009068)	3.96497797
64	dicarboxylic acid biosynthetic process (GO:0043650)	3.94832846
65	regulation of phosphatase activity (GO:0010921)	3.85775207
66	negative regulation of JNK cascade (GO:0046329)	3.82378217
67	negative regulation of smooth muscle contraction (GO:0045986)	3.81179992
68	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)	3.80801952
69	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.80518137
70	calcium ion-dependent exocytosis (GO:0017156)	3.80036358
71	membrane repolarization (GO:0086009)	3.76375392
72	oligosaccharide biosynthetic process (GO:0009312)	3.71574329
73	sex determination (GO:0007530)	3.69298864
74	DNA double-strand break processing (GO:0000729)	3.68554746
75	meiotic nuclear division (GO:0007126)	3.62482757
76	polyamine metabolic process (GO:0006595)	3.58697754
77	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.53920279
78	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.53115558
79	negative regulation of inclusion body assembly (GO:0090084)	3.44901523
80	cellular polysaccharide metabolic process (GO:0044264)	3.39859263
81	indole-containing compound catabolic process (GO:0042436)	3.36777775
82	indolalkylamine catabolic process (GO:0046218)	3.36777775
83	tryptophan catabolic process (GO:0006569)	3.36777775
84	negative regulation of stress-activated MAPK cascade (GO:0032873)	3.34638247
85	negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)	3.34638247
86	glutathione derivative biosynthetic process (GO:1901687)	3.33773149
87	glutathione derivative metabolic process (GO:1901685)	3.33773149
88	plasma membrane fusion (GO:0045026)	3.32895102
89	potassium ion import (GO:0010107)	3.27262180
90	phosphatidylethanolamine metabolic process (GO:0046337)	3.24005956
91	dicarboxylic acid catabolic process (GO:0043649)	3.21132534
92	polysaccharide metabolic process (GO:0005976)	3.17060561
93	histone H3-K9 demethylation (GO:0033169)	3.13384791
94	regulation of protein kinase C signaling (GO:0090036)	3.11772151
95	negative regulation of striated muscle cell apoptotic process (GO:0010664)	3.11719611
96	negative regulation of metanephros development (GO:0072217)	3.11616068
97	sex differentiation (GO:0007548)	3.08574603
98	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	11.7555184
99	regulation of phosphoprotein phosphatase activity (GO:0043666)	10.9729929
100	positive regulation of catecholamine secretion (GO:0033605)	10.7648124

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	9.99066618
2	IGF1R_20145208_ChIP-Seq_DFB_Human	5.11638441
3	ESR1_20079471_ChIP-ChIP_T-47D_Human	4.13634453
4	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	3.11761672
5	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.81375619
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.68168389
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.44734596
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.32357812
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.19275709
10	FUS_26573619_Chip-Seq_HEK293_Human	2.09263657
11	AHR_22903824_ChIP-Seq_MCF-7_Human	2.02170338
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	10.8518665
13	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.96335186
14	AR_21572438_ChIP-Seq_LNCaP_Human	1.91505831
15	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.88659927
16	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.88659927
17	GBX2_23144817_ChIP-Seq_PC3_Human	1.88245789
18	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.81117434
19	AR_21909140_ChIP-Seq_LNCAP_Human	1.75131532
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.71652055
21	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.64973124
22	NANOG_20526341_ChIP-Seq_ESCs_Human	1.63286281
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.56088740
24	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.50919466
25	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44911279
26	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.43190891
27	RAC3_21632823_ChIP-Seq_H3396_Human	1.40907369
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.40315123
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40315123
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.40272252
31	CTCF_27219007_Chip-Seq_Bcells_Human	1.40003799
32	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.39144964
33	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.39096102
34	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.34678800
35	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.34227620
36	ERA_21632823_ChIP-Seq_H3396_Human	1.30406379
37	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.30230600
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.27457620
39	OCT4_20526341_ChIP-Seq_ESCs_Human	1.26359978
40	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.25665121
41	SMC4_20622854_ChIP-Seq_HELA_Human	1.21890980
42	TBL1_22424771_ChIP-Seq_293T_Human	1.18919557
43	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.18453737
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17994724
45	VDR_22108803_ChIP-Seq_LS180_Human	1.17712965
46	GATA1_22025678_ChIP-Seq_K562_Human	1.17047757
47	TP53_18474530_ChIP-ChIP_U2OS_Human	1.15921122
48	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.14416156
49	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13344656
50	MYC_19829295_ChIP-Seq_ESCs_Human	1.13038201
51	P300_19829295_ChIP-Seq_ESCs_Human	1.09201634
52	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09173580
53	ERG_20517297_ChIP-Seq_VCAP_Human	1.08987658
54	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.08362231
55	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.06981808
56	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04242561
57	SMAD4_21799915_ChIP-Seq_A2780_Human	1.03710278
58	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.00661398
59	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.98784342
60	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.97952792
61	ZNF263_19887448_ChIP-Seq_K562_Human	0.96569775
62	RXR_22108803_ChIP-Seq_LS180_Human	0.96258067
63	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.94307708
64	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.93623232
65	SOX2_19829295_ChIP-Seq_ESCs_Human	0.93420544
66	NANOG_19829295_ChIP-Seq_ESCs_Human	0.93420544
67	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92420081
68	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.90948978
69	CTCF_20526341_ChIP-Seq_ESCs_Human	0.89789819
70	SPI1_20517297_ChIP-Seq_HL60_Human	0.89466754
71	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.88053382
72	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.86164595
73	AR_25329375_ChIP-Seq_VCAP_Human	0.85552849
74	ELF5_23300383_ChIP-Seq_T47D_Human	0.85046377
75	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.84766939
76	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.83984604
77	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.83955720
78	HOXB7_26014856_ChIP-Seq_BT474_Human	0.83178809
79	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.82982295
80	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.80550747
81	P300_27268052_Chip-Seq_Bcells_Human	0.79978783
82	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.79403019
83	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.79337666
84	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.79000311
85	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.78359683
86	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.78272232
87	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.77890258
88	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.77184721
89	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.76814975
90	IRF1_19129219_ChIP-ChIP_H3396_Human	0.75761115
91	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.74457424
92	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.74440051
93	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.74062273
94	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.73874467
95	STAT3_23295773_ChIP-Seq_U87_Human	0.73349225
96	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.72192777
97	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.71557357
98	PHF8_20622854_ChIP-Seq_HELA_Human	0.69116289
99	GF1_26923725_Chip-Seq_HPCs_Mouse	0.68604325
100	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.68218474

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	8.45517144
2	MP0003315_abnormal_perineum_morphology	8.00441124
3	MP0008004_abnormal_stomach_pH	6.48262786
4	MP0002160_abnormal_reproductive_system	4.35060522
5	MP0005360_urolithiasis	3.98987646
6	MP0000537_abnormal_urethra_morphology	3.37765812
7	MP0005058_abnormal_lysosome_morphology	3.07893546
8	MP0003045_fibrosis	2.99232095
9	MP0003698_abnormal_male_reproductive	2.90709250
10	MP0001929_abnormal_gametogenesis	2.62596040
11	MP0001984_abnormal_olfaction	2.56729311
12	MP0002132_abnormal_respiratory_system	2.37203163
13	MP0003136_yellow_coat_color	2.28876124
14	MP0010386_abnormal_urinary_bladder	2.27530012
15	MP0008995_early_reproductive_senescence	2.25907011
16	MP0005647_abnormal_sex_gland	2.19741551
17	MP0005389_reproductive_system_phenotype	2.11020425
18	MP0001664_abnormal_digestion	2.02312388
19	MP0005499_abnormal_olfactory_system	2.01095683
20	MP0005394_taste/olfaction_phenotype	2.01095683
21	MP0010368_abnormal_lymphatic_system	1.99131379
22	MP0005187_abnormal_penis_morphology	1.88230570
23	MP0000538_abnormal_urinary_bladder	1.72768327
24	MP0001188_hyperpigmentation	1.60502412
25	MP0002210_abnormal_sex_determination	1.57024407
26	MP0001905_abnormal_dopamine_level	1.57000612
27	MP0006072_abnormal_retinal_apoptosis	1.54570843
28	MP0001145_abnormal_male_reproductive	1.50611664
29	MP0002161_abnormal_fertility/fecundity	1.47772146
30	MP0003123_paternal_imprinting	1.46734985
31	MP0000465_gastrointestinal_hemorrhage	1.42281512
32	MP0001849_ear_inflammation	1.39144100
33	MP0001661_extended_life_span	1.36447932
34	MP0003936_abnormal_reproductive_system	1.31840356
35	MP0000653_abnormal_sex_gland	1.30874269
36	MP0004272_abnormal_basement_membrane	1.25445866
37	MP0009697_abnormal_copulation	1.19542204
38	MP0005409_darkened_coat_color	1.14183226
39	MP0003632_abnormal_nervous_system	1.09815915
40	MP0005646_abnormal_pituitary_gland	1.01853828
41	MP0000343_altered_response_to	0.99862653
42	MP0006036_abnormal_mitochondrial_physio	0.99070834
43	MP0001919_abnormal_reproductive_system	0.98311171
44	MP0002127_abnormal_cardiovascular_syste	0.97469345
45	MP0001501_abnormal_sleep_pattern	0.97045910
46	MP0005395_other_phenotype	0.87893923
47	MP0002168_other_aberrant_phenotype	0.86874423
48	MP0003718_maternal_effect	0.86797864
49	MP0004085_abnormal_heartbeat	0.84226756
50	MP0004084_abnormal_cardiac_muscle	0.83983141
51	MP0000470_abnormal_stomach_morphology	0.83598737
52	MP0003631_nervous_system_phenotype	0.81891806
53	MP0005248_abnormal_Harderian_gland	0.81060788
54	MP0002233_abnormal_nose_morphology	0.80255740
55	MP0002249_abnormal_larynx_morphology	0.79638115
56	MP0002102_abnormal_ear_morphology	0.78715496
57	MP0001529_abnormal_vocalization	0.78143901
58	MP0008789_abnormal_olfactory_epithelium	0.73758574
59	MP0005253_abnormal_eye_physiology	0.73689566
60	MP0002638_abnormal_pupillary_reflex	0.72547499
61	MP0004381_abnormal_hair_follicle	0.72046412
62	MP0000631_abnormal_neuroendocrine_gland	0.71150396
63	MP0003806_abnormal_nucleotide_metabolis	0.66574221
64	MP0000678_abnormal_parathyroid_gland	0.66347823
65	MP0003385_abnormal_body_wall	0.60587270
66	MP0004036_abnormal_muscle_relaxation	0.57085821
67	MP0003633_abnormal_nervous_system	0.56445428
68	MP0005174_abnormal_tail_pigmentation	0.56219840
69	MP0002272_abnormal_nervous_system	0.56151697
70	MP0010234_abnormal_vibrissa_follicle	0.53835744
71	MP0001270_distended_abdomen	0.53569698
72	MP0000230_abnormal_systemic_arterial	0.52702274
73	MP0005620_abnormal_muscle_contractility	0.52335709
74	MP0008877_abnormal_DNA_methylation	0.51709120
75	MP0002090_abnormal_vision	0.51079162
76	MP0002998_abnormal_bone_remodeling	0.50289731
77	MP0005595_abnormal_vascular_smooth	0.49870754
78	MP0003879_abnormal_hair_cell	0.49713780
79	MP0003938_abnormal_ear_development	0.49333140
80	MP0003635_abnormal_synaptic_transmissio	0.46725285
81	MP0003868_abnormal_feces_composition	0.46563500
82	MP0000049_abnormal_middle_ear	0.45950159
83	MP0001756_abnormal_urination	0.44906478
84	MP0000747_muscle_weakness	0.44532663
85	MP0009250_abnormal_appendicular_skeleto	0.43849150
86	MP0003828_pulmonary_edema	0.42576570
87	MP0005166_decreased_susceptibility_to	0.41425158
88	MP0000762_abnormal_tongue_morphology	0.41265975
89	MP0000627_abnormal_mammary_gland	0.38888474
90	MP0001968_abnormal_touch/_nociception	0.38657018
91	MP0002752_abnormal_somatic_nervous	0.36882860
92	MP0000920_abnormal_myelination	0.36153761
93	MP0001485_abnormal_pinna_reflex	0.35118249
94	MP0001764_abnormal_homeostasis	0.34951005
95	MP0000462_abnormal_digestive_system	0.34880005
96	MP0009840_abnormal_foam_cell	0.34036925
97	MP0005391_vision/eye_phenotype	0.34003052
98	MP0002115_abnormal_skeleton_extremities	0.33412147
99	MP0004782_abnormal_surfactant_physiolog	0.31996414
100	MP0008058_abnormal_DNA_repair	0.29920929

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Sex reversal (HP:0012245)	9.36755773
2	Abnormal sex determination (HP:0012244)	9.36755773
3	Hypoplasia of the uterus (HP:0000013)	7.81861388
4	Resting tremor (HP:0002322)	7.44907643
5	Gonadal dysgenesis (HP:0000133)	6.52866796
6	Abnormality of the columella (HP:0009929)	5.89148708
7	Aplasia/hypoplasia of the uterus (HP:0008684)	5.85723278
8	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.85160816
9	Reduced antithrombin III activity (HP:0001976)	5.73298594
10	Male pseudohermaphroditism (HP:0000037)	5.53153667
11	Abnormal respiratory motile cilium physiology (HP:0012261)	5.05289112
12	Colitis (HP:0002583)	5.01461257
13	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.98722088
14	Absent/shortened dynein arms (HP:0200106)	4.98722088
15	Abnormal ciliary motility (HP:0012262)	4.85650402
16	Germ cell neoplasia (HP:0100728)	4.72229110
17	Ventricular fibrillation (HP:0001663)	4.64558020
18	Postural instability (HP:0002172)	4.63742091
19	Infertility (HP:0000789)	4.63666729
20	Facial hemangioma (HP:0000329)	4.55153401
21	Thoracic kyphosis (HP:0002942)	4.39437968
22	Urinary urgency (HP:0000012)	4.08567951
23	Cerebellar dysplasia (HP:0007033)	3.96187316
24	Thoracolumbar scoliosis (HP:0002944)	3.92056459
25	Abnormal respiratory motile cilium morphology (HP:0005938)	3.82895824
26	Abnormal respiratory epithelium morphology (HP:0012253)	3.82895824
27	Abnormality of the intrinsic pathway (HP:0010989)	3.49748990
28	Self-mutilation (HP:0000742)	3.47453252
29	Abnormality of the lumbar spine (HP:0100712)	3.46960380
30	Abnormality of male internal genitalia (HP:0000022)	3.38975627
31	Type II lissencephaly (HP:0007260)	3.33516761
32	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	3.29065385
33	Inflammation of the large intestine (HP:0002037)	3.23619708
34	Retinal dysplasia (HP:0007973)	3.19299192
35	Protruding tongue (HP:0010808)	3.13900400
36	Atonic seizures (HP:0010819)	3.13728754
37	Capillary hemangiomas (HP:0005306)	3.11653824
38	Retinal atrophy (HP:0001105)	3.10673569
39	Gastrointestinal inflammation (HP:0004386)	3.01501073
40	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.90439597
41	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.90439597
42	Rhinitis (HP:0012384)	2.83209936
43	Abnormality of the thoracic spine (HP:0100711)	2.82681509
44	Sensory axonal neuropathy (HP:0003390)	2.76834095
45	Nasal polyposis (HP:0100582)	2.67213513
46	Abnormality of the frontal sinuses (HP:0002687)	2.62992139
47	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	2.60106669
48	Buphthalmos (HP:0000557)	2.58580551
49	Occipital encephalocele (HP:0002085)	2.51486967
50	Facial diplegia (HP:0001349)	2.50771342
51	Unsteady gait (HP:0002317)	2.46827056
52	Abnormality of the nasal mucosa (HP:0000433)	2.41402748
53	Hypothermia (HP:0002045)	2.41378570
54	Congenital sensorineural hearing impairment (HP:0008527)	2.39053515
55	Inability to walk (HP:0002540)	2.34683274
56	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	2.31147047
57	Absent thumb (HP:0009777)	2.25841985
58	Prolonged QT interval (HP:0001657)	2.25666912
59	Syncope (HP:0001279)	2.24418827
60	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.24001445
61	Anterior segment dysgenesis (HP:0007700)	2.22662665
62	Bronchiectasis (HP:0002110)	2.09516755
63	Chronic bronchitis (HP:0004469)	2.09407823
64	Spinal rigidity (HP:0003306)	2.07717596
65	High anterior hairline (HP:0009890)	2.01551073
66	Coxa valga (HP:0002673)	2.00308717
67	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.98838305
68	Polyneuropathy (HP:0001271)	1.97128098
69	Aortic aneurysm (HP:0004942)	1.94504055
70	Vitreoretinal degeneration (HP:0000655)	1.92203991
71	Abnormal protein glycosylation (HP:0012346)	1.87045024
72	Abnormal glycosylation (HP:0012345)	1.87045024
73	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.87045024
74	Abnormal protein N-linked glycosylation (HP:0012347)	1.87045024
75	Absent speech (HP:0001344)	1.85474427
76	Male infertility (HP:0003251)	1.85248786
77	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.84775219
78	Abnormality of the ileum (HP:0001549)	1.81070547
79	Chronic sinusitis (HP:0011109)	1.78740058
80	Aplasia cutis congenita (HP:0001057)	1.76811886
81	Median cleft lip (HP:0000161)	1.75028298
82	Generalized hypotonia (HP:0001290)	1.73519293
83	Depression (HP:0000716)	1.69592998
84	Difficulty climbing stairs (HP:0003551)	1.68095707
85	Renal dysplasia (HP:0000110)	1.63647592
86	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.63078871
87	Anxiety (HP:0000739)	1.61093708
88	Optic nerve hypoplasia (HP:0000609)	1.60797452
89	Intellectual disability, progressive (HP:0006887)	1.60038512
90	Bradykinesia (HP:0002067)	1.59484065
91	Meckel diverticulum (HP:0002245)	1.56367302
92	Atrial fibrillation (HP:0005110)	1.53560177
93	Exercise-induced myalgia (HP:0003738)	1.53345436
94	Abnormality of the vitreous humor (HP:0004327)	1.49838152
95	High pitched voice (HP:0001620)	1.49608580
96	Flattened epiphyses (HP:0003071)	1.48196584
97	Congenital glaucoma (HP:0001087)	1.47243941
98	Muscular dystrophy (HP:0003560)	1.44557153
99	Squamous cell carcinoma (HP:0002860)	1.44328920
100	True hermaphroditism (HP:0010459)	1.43655852

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK3	6.42641895
2	TLK1	3.91958167
3	ZAK	3.81136140
4	MYLK	3.50768826
5	RPS6KA5	3.02899817
6	NEK2	2.36329835
7	LATS1	2.20019313
8	PINK1	12.0805790
9	STK38	1.42123433
10	MAP2K7	1.39747802
11	CDK3	1.22172315
12	LATS2	1.16931389
13	STK38L	1.15378736
14	SGK494	1.15006712
15	SGK223	1.15006712
16	FRK	1.03566810
17	CSNK1A1L	0.98849196
18	MST1R	0.92070809
19	DYRK3	0.91895929
20	PRKCQ	0.91112309
21	MAPK15	0.87243101
22	CDC42BPA	0.86266610
23	MAP3K9	0.83941861
24	CSNK1G3	0.81121705
25	VRK1	0.80424926
26	ARAF	0.80201218
27	BMPR1B	0.79933143
28	CDK14	0.78484612
29	MAP3K13	0.71367616
30	OBSCN	0.70198157
31	MELK	0.69773812
32	FGR	0.65714514
33	CSNK1G1	0.64944743
34	FGFR2	0.64043279
35	DAPK3	0.61963767
36	MAP3K1	0.59124959
37	PAK1	0.58446766
38	CSNK1G2	0.57788440
39	MAP3K10	0.55159439
40	PKN1	0.52431820
41	PAK2	0.52193693
42	MAP3K5	0.50552423
43	EIF2AK3	0.50019920
44	DYRK2	0.48132945
45	PRKG2	0.47358309
46	RPS6KB1	0.46218342
47	NME2	0.44453194
48	CDK5	0.43777381
49	TGFBR1	0.43033836
50	RET	0.41475825
51	TIE1	0.41282250
52	ROCK1	0.39488908
53	EGFR	0.38532902
54	SGK2	0.36778035
55	ATM	0.36767703
56	CAMK1	0.36645313
57	MOS	0.36565522
58	ILK	0.34718221
59	PDPK1	0.33920570
60	RPS6KA4	0.32765396
61	PRKG1	0.31020568
62	MAPK12	0.29220080
63	PKN2	0.27660651
64	CLK1	0.27556596
65	CSNK1A1	0.27428821
66	EEF2K	0.27422689
67	ICK	0.26464549
68	FES	0.26422684
69	PTK2B	0.25784670
70	ADRBK2	0.24917496
71	CDK8	0.23441839
72	AKT2	0.21532868
73	GRK1	0.20904276
74	RPS6KA1	0.20545706
75	PDK1	0.19998448
76	RPS6KA3	0.19860688
77	GRK6	0.19669410
78	MTOR	0.19588658
79	IRAK2	0.19520056
80	NLK	0.18932323
81	CCNB1	0.18380755
82	BTK	0.18303762
83	CDK12	0.16303876
84	PRKD3	0.16153344
85	STK3	0.15582128
86	MINK1	0.15333331
87	STK4	0.14767600
88	AURKB	0.12806171
89	MAPK1	0.12383001
90	SGK3	0.11567668
91	BRAF	0.10286162
92	PIM1	0.09919074
93	PLK1	0.08045976
94	GRK5	0.05470211
95	CSNK1D	0.04256467
96	CAMK4	0.03675844
97	MET	0.03402389
98	CAMK2B	0.02667852
99	AURKA	0.02338566
100	WNK3	0.02123740

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	8.42657057
2	Gap junction_Homo sapiens_hsa04540	5.68554329
3	Hedgehog signaling pathway_Homo sapiens_hsa04340	3.70008277
4	Systemic lupus erythematosus_Homo sapiens_hsa05322	3.54119297
5	Nitrogen metabolism_Homo sapiens_hsa00910	3.30809842
6	Apoptosis_Homo sapiens_hsa04210	3.18945786
7	Phagosome_Homo sapiens_hsa04145	3.12078773
8	Alcoholism_Homo sapiens_hsa05034	2.67297239
9	Arginine biosynthesis_Homo sapiens_hsa00220	2.58895826
10	Olfactory transduction_Homo sapiens_hsa04740	2.26853171
11	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	2.15280513
12	Propanoate metabolism_Homo sapiens_hsa00640	2.08502126
13	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.08104714
14	Glutathione metabolism_Homo sapiens_hsa00480	1.80553341
15	Pyruvate metabolism_Homo sapiens_hsa00620	1.59055631
16	Butanoate metabolism_Homo sapiens_hsa00650	1.54119751
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.47339020
18	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.27241804
19	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.23553958
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.23011051
21	Chemical carcinogenesis_Homo sapiens_hsa05204	1.18598224
22	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.12095624
23	Glucagon signaling pathway_Homo sapiens_hsa04922	1.08338099
24	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.07901909
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.05482292
26	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.02142068
27	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.99269702
28	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.97899859
29	Oocyte meiosis_Homo sapiens_hsa04114	0.90442455
30	Phenylalanine metabolism_Homo sapiens_hsa00360	0.90006843
31	Renin secretion_Homo sapiens_hsa04924	0.86762953
32	PPAR signaling pathway_Homo sapiens_hsa03320	0.78703805
33	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.78284128
34	Pentose phosphate pathway_Homo sapiens_hsa00030	0.75609884
35	Taste transduction_Homo sapiens_hsa04742	0.75293085
36	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.75287841
37	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.73810080
38	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.71627016
39	Circadian rhythm_Homo sapiens_hsa04710	0.66303642
40	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.64204009
41	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.63913304
42	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.63686166
43	Tryptophan metabolism_Homo sapiens_hsa00380	0.59919610
44	mRNA surveillance pathway_Homo sapiens_hsa03015	0.59421253
45	Gastric acid secretion_Homo sapiens_hsa04971	0.59116158
46	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.57822444
47	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.53451391
48	Basal transcription factors_Homo sapiens_hsa03022	0.53189743
49	Wnt signaling pathway_Homo sapiens_hsa04310	0.50047760
50	Tyrosine metabolism_Homo sapiens_hsa00350	0.47133729
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.45835539
52	Purine metabolism_Homo sapiens_hsa00230	0.41809811
53	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39557347
54	Endometrial cancer_Homo sapiens_hsa05213	0.38788939
55	Calcium signaling pathway_Homo sapiens_hsa04020	0.37728316
56	Fatty acid degradation_Homo sapiens_hsa00071	0.37234205
57	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.36922394
58	Circadian entrainment_Homo sapiens_hsa04713	0.36274706
59	Long-term potentiation_Homo sapiens_hsa04720	0.30377090
60	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.30152502
61	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.28026591
62	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.27541553
63	Estrogen signaling pathway_Homo sapiens_hsa04915	0.26708410
64	Fanconi anemia pathway_Homo sapiens_hsa03460	0.26556740
65	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.26484486
66	Amphetamine addiction_Homo sapiens_hsa05031	0.25795472
67	Choline metabolism in cancer_Homo sapiens_hsa05231	0.24422856
68	Prostate cancer_Homo sapiens_hsa05215	0.24217344
69	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.22178897
70	RNA degradation_Homo sapiens_hsa03018	0.21836588
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.21492474
72	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.21461604
73	Metabolic pathways_Homo sapiens_hsa01100	0.21113910
74	ECM-receptor interaction_Homo sapiens_hsa04512	0.20329820
75	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.19896806
76	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.17873757
77	Sphingolipid metabolism_Homo sapiens_hsa00600	0.17873716
78	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.17706115
79	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.15722424
80	Regulation of autophagy_Homo sapiens_hsa04140	0.15357685
81	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.15079024
82	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.13846840
83	Carbon metabolism_Homo sapiens_hsa01200	0.13288306
84	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.12966094
85	Retinol metabolism_Homo sapiens_hsa00830	0.12592877
86	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.12541026
87	MAPK signaling pathway_Homo sapiens_hsa04010	0.12504975
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.12258158
89	FoxO signaling pathway_Homo sapiens_hsa04068	0.11566091
90	Melanoma_Homo sapiens_hsa05218	0.10778085
91	AMPK signaling pathway_Homo sapiens_hsa04152	0.10502352
92	Viral carcinogenesis_Homo sapiens_hsa05203	0.10422882
93	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.10318009
94	GABAergic synapse_Homo sapiens_hsa04727	0.09263155
95	cAMP signaling pathway_Homo sapiens_hsa04024	0.08726267
96	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.08080639
97	Malaria_Homo sapiens_hsa05144	0.07037497
98	RNA transport_Homo sapiens_hsa03013	0.06323486
99	Focal adhesion_Homo sapiens_hsa04510	0.06145675
100	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.05620739

LINC00684

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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