LINC00694

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)6.14082575
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.14082575
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.14082575
4positive regulation by organism of defense response of other organism involved in symbiotic interact6.14082575
5modulation by symbiont of host immune response (GO:0052553)6.14082575
6positive regulation by symbiont of host defense response (GO:0052509)6.14082575
7neutrophil activation involved in immune response (GO:0002283)5.98062633
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.60971614
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.60912118
10negative regulation of cell killing (GO:0031342)5.60912118
11cellular extravasation (GO:0045123)5.46856985
12leukocyte migration involved in inflammatory response (GO:0002523)5.35250238
13positive regulation of gamma-delta T cell activation (GO:0046645)5.15967037
14response to peptidoglycan (GO:0032494)4.96366346
15regulation of B cell receptor signaling pathway (GO:0050855)4.93348836
16neutrophil activation (GO:0042119)4.89376490
17leukocyte aggregation (GO:0070486)4.88055998
18detection of other organism (GO:0098543)4.86873559
19macrophage activation involved in immune response (GO:0002281)4.78867641
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.77212125
21detection of molecule of bacterial origin (GO:0032490)4.74145400
22regulation of interferon-beta biosynthetic process (GO:0045357)4.71641472
23antigen processing and presentation of endogenous antigen (GO:0019883)4.59202015
24microglial cell activation (GO:0001774)4.58398048
25detection of bacterium (GO:0016045)4.54546944
26positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.49495545
27detection of external biotic stimulus (GO:0098581)4.43776265
28response to interleukin-15 (GO:0070672)4.39637803
29neutrophil mediated immunity (GO:0002446)4.28578386
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.25885743
31response to host immune response (GO:0052572)4.25885743
32granulocyte activation (GO:0036230)4.25261534
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.23682396
34cellular response to interleukin-15 (GO:0071350)4.21902346
35respiratory burst (GO:0045730)4.21149060
36negative regulation of lymphocyte mediated immunity (GO:0002707)4.20364969
37negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.17302671
38negative regulation of interleukin-12 production (GO:0032695)4.09418604
39immunoglobulin mediated immune response (GO:0016064)4.00878268
40regulation of mast cell degranulation (GO:0043304)3.99619293
41macrophage activation (GO:0042116)3.95277322
42myeloid cell activation involved in immune response (GO:0002275)3.91563235
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.84182241
44detection of biotic stimulus (GO:0009595)3.81360001
45leukocyte degranulation (GO:0043299)3.79296416
46regulation of gamma-delta T cell activation (GO:0046643)3.79254028
47regulation of mast cell activation involved in immune response (GO:0033006)3.75063056
48response to host (GO:0075136)3.74996543
49response to host defenses (GO:0052200)3.74996543
50response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.74996543
51positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.72689780
52myeloid leukocyte mediated immunity (GO:0002444)3.68609420
53production of molecular mediator involved in inflammatory response (GO:0002532)3.65587347
54regulation of myeloid leukocyte mediated immunity (GO:0002886)3.61101763
55regulation of mast cell activation (GO:0033003)3.58725758
56negative regulation of leukocyte mediated immunity (GO:0002704)3.56478835
57negative regulation of phagocytosis (GO:0050765)3.47500693
58negative regulation of T cell mediated immunity (GO:0002710)3.45028915
59defense response to protozoan (GO:0042832)3.44155635
60positive regulation of mast cell activation (GO:0033005)3.42576775
61type I interferon signaling pathway (GO:0060337)3.41974746
62cellular response to type I interferon (GO:0071357)3.41974746
63response to type I interferon (GO:0034340)3.40722613
64regulation of memory T cell differentiation (GO:0043380)3.40404047
65negative regulation of T-helper cell differentiation (GO:0045623)3.38112266
66negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.38112266
67regulation of gamma-delta T cell differentiation (GO:0045586)3.37315466
68negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.32805751
69positive regulation of T cell mediated cytotoxicity (GO:0001916)3.31457359
70negative regulation of interleukin-6 production (GO:0032715)3.26988964
71positive regulation of B cell differentiation (GO:0045579)3.23574823
72positive regulation of toll-like receptor signaling pathway (GO:0034123)3.22583376
73regulation of T cell mediated cytotoxicity (GO:0001914)3.21168191
74regulation of leukocyte degranulation (GO:0043300)3.15729697
75B cell mediated immunity (GO:0019724)3.12538271
76regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.12094027
77regulation of B cell differentiation (GO:0045577)3.11362637
78response to muramyl dipeptide (GO:0032495)3.10875290
79regulation of T-helper 2 cell differentiation (GO:0045628)3.08650973
80germinal center formation (GO:0002467)3.08615993
81B cell receptor signaling pathway (GO:0050853)3.07893803
82positive regulation of interferon-alpha production (GO:0032727)3.07538746
83regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.04172076
84neutrophil chemotaxis (GO:0030593)3.03938725
85positive regulation of interleukin-17 production (GO:0032740)3.01549895
86positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.00361720
87response to protozoan (GO:0001562)2.99064958
88positive regulation of mast cell degranulation (GO:0043306)2.98340605
89positive regulation of mast cell activation involved in immune response (GO:0033008)2.98340605
90negative regulation of alpha-beta T cell activation (GO:0046636)2.97810603
91response to interferon-alpha (GO:0035455)2.97009697
92neutrophil migration (GO:1990266)2.96294076
93negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.95533409
94mast cell activation (GO:0045576)2.94029112
95negative regulation of innate immune response (GO:0045824)2.90584872
96lipopolysaccharide-mediated signaling pathway (GO:0031663)2.88987145
97dendritic cell migration (GO:0036336)2.88372024
98response to interferon-beta (GO:0035456)2.87217534
99regulation of alpha-beta T cell proliferation (GO:0046640)2.86354777
100regulation of interferon-alpha production (GO:0032647)2.86225736

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.59059723
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.99099292
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.09292033
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.50630958
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.14695052
6SCL_19346495_ChIP-Seq_HPC-7_Human3.04181111
7SPI1_23127762_ChIP-Seq_K562_Human2.91950021
8SPI1_23547873_ChIP-Seq_NB4_Human2.90429467
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.88210152
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.84530898
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.80202516
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.75657812
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.44615977
14RUNX_20019798_ChIP-Seq_JUKART_Human2.42764472
15MYB_26560356_Chip-Seq_TH2_Human2.35307596
16VDR_21846776_ChIP-Seq_THP-1_Human2.32722504
17VDR_24763502_ChIP-Seq_THP-1_Human2.32552550
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.27913566
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25001195
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.18972132
21LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.12825367
22VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.11326517
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.10147352
24MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.09246852
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06463183
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.03079631
27MAF_26560356_Chip-Seq_TH1_Human1.99524148
28UTX_26944678_Chip-Seq_JUKART_Human1.96967299
29GATA1_22025678_ChIP-Seq_K562_Human1.95040224
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.92676986
31MYB_26560356_Chip-Seq_TH1_Human1.91440749
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.88163186
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.86588677
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.85425062
35GATA3_27048872_Chip-Seq_THYMUS_Human1.85237415
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.81492050
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78052465
38SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.71963579
39MAF_26560356_Chip-Seq_TH2_Human1.70640458
40GATA3_26560356_Chip-Seq_TH2_Human1.68158664
41GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.65297837
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62984345
43GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.59878651
44GATA1_19941826_ChIP-Seq_K562_Human1.58767063
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58629081
46VDR_24787735_ChIP-Seq_THP-1_Human1.57600765
47GATA1_19941827_ChIP-Seq_MEL_Mouse1.53909698
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50588197
49BCL6_27268052_Chip-Seq_Bcells_Human1.43850435
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39721892
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39218347
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37500279
53BCOR_27268052_Chip-Seq_Bcells_Human1.30642905
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29277627
55KDM2B_26808549_Chip-Seq_DND41_Human1.28637338
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.28291735
57SPI1_20517297_ChIP-Seq_HL60_Human1.27659924
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27286468
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27102363
60TCF7_22412390_ChIP-Seq_EML_Mouse1.27005751
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26939326
62GATA2_19941826_ChIP-Seq_K562_Human1.26782726
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24723199
64NANOG_20526341_ChIP-Seq_ESCs_Human1.23526361
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22948059
66SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22625225
67CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22431036
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21686508
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20068851
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17551121
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.17312692
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17307548
73STAT1_20625510_ChIP-Seq_HELA_Human1.15634489
74P300_27268052_Chip-Seq_Bcells_Human1.15345896
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.13845322
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12279944
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11681786
78RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09955278
79E2F1_20622854_ChIP-Seq_HELA_Human1.08663260
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.07405127
81RAC3_21632823_ChIP-Seq_H3396_Human1.05658441
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05540995
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05312959
84MYC_22102868_ChIP-Seq_BL_Human1.04196709
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03222127
86SMAD_19615063_ChIP-ChIP_OVARY_Human1.02189535
87SMRT_27268052_Chip-Seq_Bcells_Human1.01764022
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99665733
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99236905
90NCOR1_26117541_ChIP-Seq_K562_Human0.98914254
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98691656
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97151490
93YY1_22570637_ChIP-Seq_MALME-3M_Human0.95951685
94BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.95835471
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95814769
96RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94872107
97P68_20966046_ChIP-Seq_HELA_Human0.93225323
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92736466
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92057653
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91811029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.82031025
2MP0003436_decreased_susceptibility_to4.01533370
3MP0003303_peritoneal_inflammation3.52733373
4MP0001835_abnormal_antigen_presentation3.31864596
5MP0002419_abnormal_innate_immunity3.18774329
6MP0002132_abnormal_respiratory_system2.99881862
7MP0005025_abnormal_response_to2.84523588
8MP0009785_altered_susceptibility_to2.83976831
9MP0001800_abnormal_humoral_immune2.70066394
10MP0005671_abnormal_response_to2.64659552
11MP0005000_abnormal_immune_tolerance2.60414975
12MP0005387_immune_system_phenotype2.59416567
13MP0001790_abnormal_immune_system2.59416567
14MP0002723_abnormal_immune_serum2.56832667
15MP0005464_abnormal_platelet_physiology2.53445529
16MP0000685_abnormal_immune_system2.51189445
17MP0002420_abnormal_adaptive_immunity2.47709197
18MP0001819_abnormal_immune_cell2.45455050
19MP0002452_abnormal_antigen_presenting2.30200325
20MP0009278_abnormal_bone_marrow2.20141200
21MP0002148_abnormal_hypersensitivity_rea2.14065328
22MP0001533_abnormal_skeleton_physiology2.03675913
23MP0006082_CNS_inflammation2.01961047
24MP0000465_gastrointestinal_hemorrhage2.00618074
25MP0002398_abnormal_bone_marrow1.91642128
26MP0002405_respiratory_system_inflammati1.91223868
27MP0000716_abnormal_immune_system1.84263435
28MP0005397_hematopoietic_system_phenotyp1.78458318
29MP0001545_abnormal_hematopoietic_system1.78458318
30MP0009764_decreased_sensitivity_to1.74639025
31MP0002277_abnormal_respiratory_mucosa1.73359044
32MP0003191_abnormal_cellular_cholesterol1.72359347
33MP0001845_abnormal_inflammatory_respons1.67811588
34MP0003300_gastrointestinal_ulcer1.66774069
35MP0003763_abnormal_thymus_physiology1.64461509
36MP0003806_abnormal_nucleotide_metabolis1.62394951
37MP0002396_abnormal_hematopoietic_system1.58770165
38MP0000689_abnormal_spleen_morphology1.57018562
39MP0002722_abnormal_immune_system1.55638540
40MP0008004_abnormal_stomach_pH1.51228676
41MP0002429_abnormal_blood_cell1.48719411
42MP0010155_abnormal_intestine_physiology1.48551798
43MP0008260_abnormal_autophagy1.47986239
44MP0008469_abnormal_protein_level1.46855849
45MP0003828_pulmonary_edema1.46780128
46MP0003866_abnormal_defecation1.46429020
47MP0005075_abnormal_melanosome_morpholog1.40991625
48MP0003172_abnormal_lysosome_physiology1.35351977
49MP0003183_abnormal_peptide_metabolism1.34846636
50MP0000703_abnormal_thymus_morphology1.31567770
51MP0005410_abnormal_fertilization1.30704453
52MP0001986_abnormal_taste_sensitivity1.30505827
53MP0003045_fibrosis1.28059241
54MP0004883_abnormal_blood_vessel1.22345667
55MP0003075_altered_response_to1.16761326
56MP0004947_skin_inflammation1.13301334
57MP0004381_abnormal_hair_follicle1.12178646
58MP0003787_abnormal_imprinting1.11713570
59MP0009333_abnormal_splenocyte_physiolog1.11220730
60MP0005377_hearing/vestibular/ear_phenot1.09929307
61MP0003878_abnormal_ear_physiology1.09929307
62MP0005310_abnormal_salivary_gland1.09676312
63MP0002928_abnormal_bile_duct1.08570373
64MP0005084_abnormal_gallbladder_morpholo1.07222690
65MP0003656_abnormal_erythrocyte_physiolo1.00573574
66MP0005164_abnormal_response_to1.00545477
67MP0001663_abnormal_digestive_system0.91896400
68MP0009765_abnormal_xenobiotic_induced0.87677452
69MP0005083_abnormal_biliary_tract0.87243355
70MP0000858_altered_metastatic_potential0.86791550
71MP0004510_myositis0.84136813
72MP0002693_abnormal_pancreas_physiology0.83895741
73MP0001851_eye_inflammation0.80487945
74MP0009763_increased_sensitivity_to0.80411172
75MP0002138_abnormal_hepatobiliary_system0.76913348
76MP0002998_abnormal_bone_remodeling0.75208147
77MP0005166_decreased_susceptibility_to0.73597770
78MP0005390_skeleton_phenotype0.73130163
79MP0000343_altered_response_to0.72868207
80MP0004130_abnormal_muscle_cell0.72777422
81MP0000015_abnormal_ear_pigmentation0.72564566
82MP0005319_abnormal_enzyme/_coenzyme0.71242562
83MP0005535_abnormal_body_temperature0.68067919
84MP0005376_homeostasis/metabolism_phenot0.65864679
85MP0001764_abnormal_homeostasis0.62667707
86MP0005174_abnormal_tail_pigmentation0.62201644
87MP0003011_delayed_dark_adaptation0.61360271
88MP0001873_stomach_inflammation0.60599981
89MP0008874_decreased_physiological_sensi0.60323608
90MP0004484_altered_response_of0.59568974
91MP0005451_abnormal_body_composition0.56972060
92MP0008877_abnormal_DNA_methylation0.56094312
93MP0004808_abnormal_hematopoietic_stem0.54687810
94MP0003195_calcinosis0.53146092
95MP0005167_abnormal_blood-brain_barrier0.50688411
96MP0003795_abnormal_bone_structure0.49128081
97MP0003638_abnormal_response/metabolism_0.49070790
98MP0009642_abnormal_blood_homeostasis0.48108248
99MP0002653_abnormal_ependyma_morphology0.48042491
100MP0003252_abnormal_bile_duct0.47967927

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)6.06800837
2Eczematoid dermatitis (HP:0000976)5.98692556
3Orchitis (HP:0100796)5.80707276
4Recurrent abscess formation (HP:0002722)5.55594635
5Optic neuritis (HP:0100653)5.50116910
6Retrobulbar optic neuritis (HP:0100654)5.50116910
7Recurrent bacterial skin infections (HP:0005406)5.45291777
8Hypochromic microcytic anemia (HP:0004840)5.23057343
9Stomatitis (HP:0010280)5.00234090
10Elevated erythrocyte sedimentation rate (HP:0003565)4.86915756
11Chronic obstructive pulmonary disease (HP:0006510)4.75876168
12Obstructive lung disease (HP:0006536)4.75876168
13Abnormality of macrophages (HP:0004311)4.74433338
14Recurrent gram-negative bacterial infections (HP:0005420)4.59825274
15Hypochromic anemia (HP:0001931)4.23837686
16Gastrointestinal infarctions (HP:0005244)4.19634844
17Prolonged bleeding time (HP:0003010)4.18826802
18Abnormal delayed hypersensitivity skin test (HP:0002963)4.07239167
19Recurrent fungal infections (HP:0002841)3.89104907
20Keratoconjunctivitis sicca (HP:0001097)3.88241985
21Encephalitis (HP:0002383)3.86297916
22Meningitis (HP:0001287)3.78755770
23Episodic fever (HP:0001954)3.67766020
24Keratoconjunctivitis (HP:0001096)3.67177918
25Recurrent skin infections (HP:0001581)3.62488145
26Mediastinal lymphadenopathy (HP:0100721)3.59890189
27Vasculitis (HP:0002633)3.39296252
28Urticaria (HP:0001025)3.36441836
29Spontaneous hematomas (HP:0007420)3.35039971
30Petechiae (HP:0000967)3.32718054
31Gingivitis (HP:0000230)3.26386208
32Abnormality of the heme biosynthetic pathway (HP:0010472)3.24536444
33Recurrent cutaneous fungal infections (HP:0011370)3.22119322
34Chronic mucocutaneous candidiasis (HP:0002728)3.22119322
35Chest pain (HP:0100749)3.14055707
36Increased IgE level (HP:0003212)3.13548933
37Hemoptysis (HP:0002105)3.08048495
38Anorexia (HP:0002039)3.06198921
39Epistaxis (HP:0000421)2.96786404
40Microcytic anemia (HP:0001935)2.96754504
41Granulocytopenia (HP:0001913)2.91229282
42Gingival bleeding (HP:0000225)2.90728072
43Arterial thrombosis (HP:0004420)2.87264053
44Leukocytosis (HP:0001974)2.85585891
45Peritonitis (HP:0002586)2.82229816
46Increased IgM level (HP:0003496)2.71022925
47Pulmonary infiltrates (HP:0002113)2.70903230
48Pulmonary embolism (HP:0002204)2.68851241
49Chronic otitis media (HP:0000389)2.66509607
50Panhypogammaglobulinemia (HP:0003139)2.54880634
51Cellulitis (HP:0100658)2.49300717
52Abnormality of T cell physiology (HP:0011840)2.48617193
53Abnormality of T cells (HP:0002843)2.47218740
54Absent/shortened dynein arms (HP:0200106)2.44511909
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.44511909
56Inflammation of the large intestine (HP:0002037)2.44483029
57Gangrene (HP:0100758)2.43534652
58Gastrointestinal inflammation (HP:0004386)2.37390553
59Abnormality of the pleura (HP:0002103)2.33690298
60Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32281777
61Keratitis (HP:0000491)2.30819110
62Eosinophilia (HP:0001880)2.29792761
63Ventricular fibrillation (HP:0001663)2.29337764
64Abnormality of iron homeostasis (HP:0011031)2.28698059
65Abnormality of T cell number (HP:0011839)2.27648627
66Purpura (HP:0000979)2.24964571
67Acne (HP:0001061)2.20650408
68Sepsis (HP:0100806)2.19847326
69Pustule (HP:0200039)2.17977819
70Abnormal hemoglobin (HP:0011902)2.17890041
71Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16964633
72Abnormality of transition element cation homeostasis (HP:0011030)2.15872848
73Glomerulopathy (HP:0100820)2.15517593
74Autoimmune hemolytic anemia (HP:0001890)2.12473838
75Hypergammaglobulinemia (HP:0010702)2.10633826
76Osteomyelitis (HP:0002754)2.08592224
77T lymphocytopenia (HP:0005403)2.07868940
78Abnormality of the peritoneum (HP:0002585)2.06549419
79Abnormal platelet volume (HP:0011876)2.05518371
80Abnormality of the endocardium (HP:0004306)2.04538338
81Increased serum ferritin (HP:0003281)2.04492810
82Hypertensive crisis (HP:0100735)2.04399685
83Stomach cancer (HP:0012126)2.03056192
84Abnormality of eosinophils (HP:0001879)2.02991048
85Vertigo (HP:0002321)1.98900397
86Toxemia of pregnancy (HP:0100603)1.96858974
87Polyneuropathy (HP:0001271)1.95943936
88Polycythemia (HP:0001901)1.94920531
89Severe visual impairment (HP:0001141)1.93593129
90Premature loss of primary teeth (HP:0006323)1.93205726
91Abnormality of the pericardium (HP:0001697)1.92434773
92Skin rash (HP:0000988)1.90444910
93Amyloidosis (HP:0011034)1.89352082
94Lymphopenia (HP:0001888)1.88832795
95Recurrent viral infections (HP:0004429)1.87666170
96Cheilitis (HP:0100825)1.87312730
97Tetany (HP:0001281)1.81393066
98Hepatosplenomegaly (HP:0001433)1.80678837
99Abnormality of cells of the lymphoid lineage (HP:0012140)1.78900759
100Aplasia/Hypoplasia of the thymus (HP:0010515)1.78756359

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.17017319
2IRAK43.52196308
3TNK23.00741797
4MAP2K32.92428486
5ERN12.80068872
6BLK2.79805545
7MAP4K12.64211026
8FES2.56688913
9GRK62.47239234
10CSK2.43803076
11TAOK32.39225052
12TYK22.21006634
13BTK2.13048112
14MARK31.95472048
15ZAP701.89702305
16EPHB11.87793288
17TXK1.85851339
18HCK1.77953547
19SYK1.70151083
20TAOK11.55572269
21IKBKE1.52606605
22JAK31.51320899
23IRAK21.46935982
24JAK21.46131038
25PTK2B1.44429597
26LYN1.42047001
27MATK1.40274935
28PINK11.40108295
29MAP3K31.39544084
30TEC1.38241087
31TBK11.36668607
32FGR1.31851187
33KIT1.31682468
34SIK31.22386284
35MAP3K111.21533006
36STK381.19230172
37MAP3K61.15053809
38DAPK21.13719596
39IRAK11.12377258
40MAP3K11.12270352
41IKBKB1.12000608
42SIK21.09934773
43LCK1.08533905
44YES11.06575918
45CDK191.06565449
46NLK1.03655017
47PRKD20.99177655
48ITK0.98346604
49MARK20.96269475
50PIK3CG0.95517869
51PDK10.94300704
52KSR20.93133885
53MAP2K40.91602612
54MAP3K140.88700739
55JAK10.86138294
56PDPK10.82600680
57FRK0.81591740
58MAP3K50.78644543
59CSF1R0.77842831
60SGK30.76067020
61PRKCQ0.72315073
62MAP3K20.69537672
63MAP3K70.68802668
64MAP2K20.64946413
65MAPK70.63987687
66BMPR20.61677656
67DYRK1B0.59893847
68FYN0.59702700
69SGK20.58934468
70MAP2K60.57108122
71PRKG20.56886551
72MAP4K20.55139467
73DYRK30.52687050
74NUAK10.52369160
75MAPK120.52026993
76STK110.51634816
77MAPK130.51397335
78RET0.48057854
79PTK60.44130805
80PIM10.40608798
81SGK2230.39118891
82SGK4940.39118891
83PRKCH0.38231524
84EPHA30.36897328
85RPS6KA60.36828878
86RPS6KL10.36030860
87RPS6KC10.36030860
88HIPK20.36000719
89RAF10.35983516
90RPS6KA10.35488256
91TESK20.33738375
92STK100.31784890
93WNK10.31132072
94MAPKAPK20.30555333
95TLK10.30137714
96ADRBK10.29649671
97PRKCZ0.29176454
98FGFR30.27710526
99CAMK10.27630193
100PRKAA20.26639974

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043803.30333386
2Leishmaniasis_Homo sapiens_hsa051403.28470063
3Staphylococcus aureus infection_Homo sapiens_hsa051503.04616458
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.43772597
5B cell receptor signaling pathway_Homo sapiens_hsa046622.32618753
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.21076949
7Tuberculosis_Homo sapiens_hsa051522.19441872
8Malaria_Homo sapiens_hsa051442.19334125
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.18873755
10Legionellosis_Homo sapiens_hsa051342.09702523
11Primary immunodeficiency_Homo sapiens_hsa053402.05353739
12Graft-versus-host disease_Homo sapiens_hsa053322.02071231
13Measles_Homo sapiens_hsa051622.01197931
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.00135173
15Allograft rejection_Homo sapiens_hsa053301.99880665
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.97981326
17Chemokine signaling pathway_Homo sapiens_hsa040621.86588717
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.85698296
19Autoimmune thyroid disease_Homo sapiens_hsa053201.81138716
20African trypanosomiasis_Homo sapiens_hsa051431.76170819
21Acute myeloid leukemia_Homo sapiens_hsa052211.72911509
22Hematopoietic cell lineage_Homo sapiens_hsa046401.71304429
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69121455
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.65342428
25Type I diabetes mellitus_Homo sapiens_hsa049401.60701409
26Phagosome_Homo sapiens_hsa041451.51316525
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.51024787
28Influenza A_Homo sapiens_hsa051641.49561427
29Platelet activation_Homo sapiens_hsa046111.48151638
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.45890975
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.45832316
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43603061
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43099210
34T cell receptor signaling pathway_Homo sapiens_hsa046601.42936992
35Herpes simplex infection_Homo sapiens_hsa051681.36112136
36Antigen processing and presentation_Homo sapiens_hsa046121.32579861
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29000883
38Toxoplasmosis_Homo sapiens_hsa051451.23210814
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.15626870
40TNF signaling pathway_Homo sapiens_hsa046681.10975388
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09860195
42Hepatitis C_Homo sapiens_hsa051601.07412829
43Glycerophospholipid metabolism_Homo sapiens_hsa005641.04349132
44Regulation of autophagy_Homo sapiens_hsa041401.03329097
45Hepatitis B_Homo sapiens_hsa051611.00368531
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98679914
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97943260
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96239855
49Pertussis_Homo sapiens_hsa051330.94636171
50Non-small cell lung cancer_Homo sapiens_hsa052230.94601584
51Olfactory transduction_Homo sapiens_hsa047400.92869410
52Apoptosis_Homo sapiens_hsa042100.90715107
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.86654982
54Rheumatoid arthritis_Homo sapiens_hsa053230.84285779
55Viral myocarditis_Homo sapiens_hsa054160.83114010
56Asthma_Homo sapiens_hsa053100.78775037
57Arachidonic acid metabolism_Homo sapiens_hsa005900.77510293
58Prolactin signaling pathway_Homo sapiens_hsa049170.74235809
59VEGF signaling pathway_Homo sapiens_hsa043700.72645614
60Shigellosis_Homo sapiens_hsa051310.70550307
61Other glycan degradation_Homo sapiens_hsa005110.69976032
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.69831738
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69213768
64Dorso-ventral axis formation_Homo sapiens_hsa043200.68272545
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66149044
66Choline metabolism in cancer_Homo sapiens_hsa052310.65997062
67Salmonella infection_Homo sapiens_hsa051320.65285467
68Endocytosis_Homo sapiens_hsa041440.61129008
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.60428648
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.60057649
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59749422
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58111652
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57716102
74Type II diabetes mellitus_Homo sapiens_hsa049300.57502174
75Pancreatic cancer_Homo sapiens_hsa052120.57331036
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56429708
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53721174
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51418714
79Collecting duct acid secretion_Homo sapiens_hsa049660.49846570
80FoxO signaling pathway_Homo sapiens_hsa040680.49794161
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49283387
82Morphine addiction_Homo sapiens_hsa050320.48470445
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47538809
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47470889
85Insulin resistance_Homo sapiens_hsa049310.46414393
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.43463733
87Viral carcinogenesis_Homo sapiens_hsa052030.42449489
88Chronic myeloid leukemia_Homo sapiens_hsa052200.41636547
89Linoleic acid metabolism_Homo sapiens_hsa005910.40901925
90MAPK signaling pathway_Homo sapiens_hsa040100.40167998
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39288998
92Inositol phosphate metabolism_Homo sapiens_hsa005620.38187362
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37025911
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.34829111
95Ether lipid metabolism_Homo sapiens_hsa005650.33812383
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33014388
97Cholinergic synapse_Homo sapiens_hsa047250.31587474
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29752893
99Glycerolipid metabolism_Homo sapiens_hsa005610.28472193
100Epstein-Barr virus infection_Homo sapiens_hsa051690.27749171

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