ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	5.38826813
2	tryptophan catabolic process (GO:0006569)	5.13865291
3	indole-containing compound catabolic process (GO:0042436)	5.13865291
4	indolalkylamine catabolic process (GO:0046218)	5.13865291
5	sperm motility (GO:0030317)	5.12473225
6	behavioral response to nicotine (GO:0035095)	5.04841488
7	male meiosis (GO:0007140)	4.92173944
8	multicellular organism reproduction (GO:0032504)	4.67525147
9	acrosome reaction (GO:0007340)	4.66507424
10	response to pheromone (GO:0019236)	4.57206565
11	DNA methylation involved in gamete generation (GO:0043046)	4.50109709
12	spermatid development (GO:0007286)	4.29293869
13	tryptophan metabolic process (GO:0006568)	4.26375916
14	synapsis (GO:0007129)	4.23251495
15	indolalkylamine metabolic process (GO:0006586)	4.22699280
16	epithelial cilium movement (GO:0003351)	4.14426333
17	cilium or flagellum-dependent cell motility (GO:0001539)	3.83916457
18	kynurenine metabolic process (GO:0070189)	3.83269861
19	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.71521392
20	L-fucose metabolic process (GO:0042354)	3.67517358
21	L-fucose catabolic process (GO:0042355)	3.67517358
22	fucose catabolic process (GO:0019317)	3.67517358
23	protein polyglutamylation (GO:0018095)	3.61681109
24	axoneme assembly (GO:0035082)	3.61632619
25	amine catabolic process (GO:0009310)	3.61597215
26	cellular biogenic amine catabolic process (GO:0042402)	3.61597215
27	organic cation transport (GO:0015695)	3.60701366
28	cellular ketone body metabolic process (GO:0046950)	3.56400773
29	male meiosis I (GO:0007141)	3.46196170
30	detection of light stimulus involved in visual perception (GO:0050908)	3.42728060
31	detection of light stimulus involved in sensory perception (GO:0050962)	3.42728060
32	cilium movement (GO:0003341)	3.38740924
33	DNA deamination (GO:0045006)	3.36167613
34	motile cilium assembly (GO:0044458)	3.22942106
35	ketone body metabolic process (GO:1902224)	3.20144070
36	reproduction (GO:0000003)	3.14564263
37	sperm-egg recognition (GO:0035036)	3.13647723
38	indole-containing compound metabolic process (GO:0042430)	3.12824746
39	axonemal dynein complex assembly (GO:0070286)	3.04002971
40	regulation of cilium movement (GO:0003352)	3.01799122
41	fusion of sperm to egg plasma membrane (GO:0007342)	2.97932861
42	negative regulation of mast cell activation (GO:0033004)	2.92574058
43	establishment of protein localization to Golgi (GO:0072600)	2.92023791
44	NAD biosynthetic process (GO:0009435)	2.89793469
45	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.89515822
46	protein localization to cilium (GO:0061512)	2.88025091
47	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.87088326
48	cell-cell recognition (GO:0009988)	2.84683174
49	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.83144809
50	platelet dense granule organization (GO:0060155)	2.82308138
51	positive regulation of defense response to virus by host (GO:0002230)	2.81676165
52	phosphatidylethanolamine metabolic process (GO:0046337)	2.80985503
53	RNA destabilization (GO:0050779)	2.80973869
54	aromatic amino acid family catabolic process (GO:0009074)	2.80635428
55	positive regulation of catecholamine secretion (GO:0033605)	2.76110659
56	cellular response to exogenous dsRNA (GO:0071360)	2.74227393
57	cilium organization (GO:0044782)	2.72701833
58	cilium morphogenesis (GO:0060271)	2.71706685
59	cilium assembly (GO:0042384)	2.66136391
60	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.64229718
61	calcium ion-dependent exocytosis (GO:0017156)	2.64060549
62	meiotic nuclear division (GO:0007126)	2.62756827
63	photoreceptor cell maintenance (GO:0045494)	2.61678313
64	basic amino acid transport (GO:0015802)	2.60779109
65	mannosylation (GO:0097502)	2.57895770
66	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.56941843
67	alanine transport (GO:0032328)	2.56472196
68	chromosome organization involved in meiosis (GO:0070192)	2.56005156
69	cellular response to ATP (GO:0071318)	2.54349183
70	protein targeting to Golgi (GO:0000042)	2.54251970
71	single fertilization (GO:0007338)	2.54098341
72	mast cell activation involved in immune response (GO:0002279)	2.53487883
73	mast cell degranulation (GO:0043303)	2.53487883
74	preassembly of GPI anchor in ER membrane (GO:0016254)	2.52630127
75	coenzyme catabolic process (GO:0009109)	2.49264261
76	protein complex biogenesis (GO:0070271)	2.49028715
77	meiosis I (GO:0007127)	2.48599265
78	plasma membrane fusion (GO:0045026)	2.47367344
79	germ cell development (GO:0007281)	2.47009678
80	reciprocal DNA recombination (GO:0035825)	2.46583174
81	reciprocal meiotic recombination (GO:0007131)	2.46583174
82	positive regulation of fatty acid transport (GO:2000193)	2.41129208
83	regulation of action potential (GO:0098900)	2.40930374
84	negative regulation of cAMP-mediated signaling (GO:0043951)	2.40711698
85	regulation of microtubule-based movement (GO:0060632)	2.39849748
86	protein localization to Golgi apparatus (GO:0034067)	2.39230656
87	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.39039541
88	cAMP catabolic process (GO:0006198)	2.38311666
89	meiotic chromosome segregation (GO:0045132)	2.35555599
90	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.34659245
91	primary amino compound metabolic process (GO:1901160)	2.33955623
92	positive regulation of prostaglandin secretion (GO:0032308)	2.32086369
93	regulation of meiosis I (GO:0060631)	2.30505884
94	synaptic transmission, cholinergic (GO:0007271)	2.29398804
95	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.28579710
96	spermatogenesis (GO:0007283)	2.27150509
97	male gamete generation (GO:0048232)	2.27090884
98	intraciliary transport (GO:0042073)	2.26296650
99	NADH dehydrogenase complex assembly (GO:0010257)	2.26065871
100	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.26065871

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.00535800
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.61022866
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.11809771
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.98972547
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.98920378
6	VDR_22108803_ChIP-Seq_LS180_Human	2.96422382
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.36206567
8	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.28801436
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.19218206
10	ER_23166858_ChIP-Seq_MCF-7_Human	2.12376964
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.11114000
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02056299
13	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.85365847
14	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.80096701
15	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.80096701
16	FUS_26573619_Chip-Seq_HEK293_Human	1.78083441
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.76810619
18	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.73812597
19	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.68323134
20	BCAT_22108803_ChIP-Seq_LS180_Human	1.66540397
21	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.65978080
22	CBP_20019798_ChIP-Seq_JUKART_Human	1.65978080
23	P300_19829295_ChIP-Seq_ESCs_Human	1.62453134
24	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.52642998
25	ERA_21632823_ChIP-Seq_H3396_Human	1.50630237
26	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.50052923
27	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.47050211
28	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.44684929
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.36820861
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.35228880
31	STAT3_23295773_ChIP-Seq_U87_Human	1.35183561
32	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.34660518
33	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.34608526
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.33956887
35	MYC_19829295_ChIP-Seq_ESCs_Human	1.33777390
36	EWS_26573619_Chip-Seq_HEK293_Human	1.33456936
37	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.33454966
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.33142057
39	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.32970438
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.32039921
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.32039921
42	NANOG_20526341_ChIP-Seq_ESCs_Human	1.31940097
43	AR_25329375_ChIP-Seq_VCAP_Human	1.29255164
44	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.28839675
45	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.28220185
46	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.27448508
47	HOXB7_26014856_ChIP-Seq_BT474_Human	1.27108526
48	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.26509545
49	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26015051
50	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.25835029
51	TCF4_23295773_ChIP-Seq_U87_Human	1.25700538
52	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.25638157
53	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25612143
54	OCT4_20526341_ChIP-Seq_ESCs_Human	1.25386222
55	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24945335
56	RAC3_21632823_ChIP-Seq_H3396_Human	1.23787736
57	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23778962
58	SMAD4_21799915_ChIP-Seq_A2780_Human	1.22612119
59	GATA3_26560356_Chip-Seq_TH2_Human	1.22041429
60	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.21416872
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18919600
62	NCOR_22424771_ChIP-Seq_293T_Human	1.17539348
63	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.16868137
64	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.16554703
65	TCF4_22108803_ChIP-Seq_LS180_Human	1.16546000
66	AR_21572438_ChIP-Seq_LNCaP_Human	1.16356079
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16217471
68	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.14879873
69	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12388319
70	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12388319
71	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.12142883
72	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.11158059
73	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.09899910
74	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.09567419
75	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08846262
76	AR_20517297_ChIP-Seq_VCAP_Human	1.08829001
77	REST_21632747_ChIP-Seq_MESCs_Mouse	1.07995466
78	TAF2_19829295_ChIP-Seq_ESCs_Human	1.07772075
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.07433809
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.07369424
81	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.06468514
82	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.06277591
83	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.06145410
84	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.06029930
85	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.05609644
86	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04733141
87	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.04480395
88	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.02652097
89	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.02206502
90	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.99018007
91	SMRT_27268052_Chip-Seq_Bcells_Human	0.95880571
92	CDX2_22108803_ChIP-Seq_LS180_Human	0.95730628
93	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.95686764
94	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.95662463
95	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.94891664
96	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.94830339
97	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94601645
98	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94030177
99	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.91427731
100	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.90150033

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	4.42445156
2	MP0000569_abnormal_digit_pigmentation	2.96766162
3	MP0008877_abnormal_DNA_methylation	2.79895114
4	MP0003195_calcinosis	2.78661101
5	MP0005551_abnormal_eye_electrophysiolog	2.25812554
6	MP0003646_muscle_fatigue	2.21339523
7	MP0005174_abnormal_tail_pigmentation	2.13751040
8	MP0002102_abnormal_ear_morphology	2.02538607
9	MP0003136_yellow_coat_color	1.95551005
10	MP0003698_abnormal_male_reproductive	1.90391521
11	MP0001968_abnormal_touch/_nociception	1.90104665
12	MP0002876_abnormal_thyroid_physiology	1.88608545
13	MP0002160_abnormal_reproductive_system	1.85141047
14	MP0001986_abnormal_taste_sensitivity	1.84890724
15	MP0003787_abnormal_imprinting	1.82725305
16	MP0002837_dystrophic_cardiac_calcinosis	1.77145165
17	MP0008875_abnormal_xenobiotic_pharmacok	1.75083367
18	MP0001501_abnormal_sleep_pattern	1.75036070
19	MP0001929_abnormal_gametogenesis	1.72961232
20	MP0005646_abnormal_pituitary_gland	1.68379334
21	MP0005671_abnormal_response_to	1.66945679
22	MP0001835_abnormal_antigen_presentation	1.66057978
23	MP0006072_abnormal_retinal_apoptosis	1.62058613
24	MP0001984_abnormal_olfaction	1.60149407
25	MP0000372_irregular_coat_pigmentation	1.57608228
26	MP0005253_abnormal_eye_physiology	1.57314848
27	MP0005389_reproductive_system_phenotype	1.53322489
28	MP0002638_abnormal_pupillary_reflex	1.52206738
29	MP0009046_muscle_twitch	1.48645345
30	MP0010386_abnormal_urinary_bladder	1.46103934
31	MP0008004_abnormal_stomach_pH	1.44395907
32	MP0005379_endocrine/exocrine_gland_phen	1.44094550
33	MP0005645_abnormal_hypothalamus_physiol	1.43113148
34	MP0000015_abnormal_ear_pigmentation	1.41738423
35	MP0008995_early_reproductive_senescence	1.39278127
36	MP0002138_abnormal_hepatobiliary_system	1.38208419
37	MP0005377_hearing/vestibular/ear_phenot	1.38132720
38	MP0003878_abnormal_ear_physiology	1.38132720
39	MP0005647_abnormal_sex_gland	1.35734716
40	MP0002163_abnormal_gland_morphology	1.34857239
41	MP0005167_abnormal_blood-brain_barrier	1.33900929
42	MP0002148_abnormal_hypersensitivity_rea	1.31261762
43	MP0008872_abnormal_physiological_respon	1.30199625
44	MP0000685_abnormal_immune_system	1.29972892
45	MP0009785_altered_susceptibility_to	1.27813398
46	MP0003806_abnormal_nucleotide_metabolis	1.27507375
47	MP0009764_decreased_sensitivity_to	1.26600389
48	MP0005360_urolithiasis	1.24947006
49	MP0009745_abnormal_behavioral_response	1.23866502
50	MP0005075_abnormal_melanosome_morpholog	1.22982112
51	MP0000427_abnormal_hair_cycle	1.22008389
52	MP0001905_abnormal_dopamine_level	1.21460527
53	MP0002653_abnormal_ependyma_morphology	1.18854553
54	MP0002210_abnormal_sex_determination	1.18299576
55	MP0001800_abnormal_humoral_immune	1.16996413
56	MP0003011_delayed_dark_adaptation	1.16633416
57	MP0005387_immune_system_phenotype	1.15789381
58	MP0001790_abnormal_immune_system	1.15789381
59	MP0001485_abnormal_pinna_reflex	1.12829551
60	MP0001919_abnormal_reproductive_system	1.07635142
61	MP0003172_abnormal_lysosome_physiology	1.06928293
62	MP0000230_abnormal_systemic_arterial	1.05997953
63	MP0002693_abnormal_pancreas_physiology	1.05575403
64	MP0001764_abnormal_homeostasis	1.04838121
65	MP0002254_reproductive_system_inflammat	1.04456142
66	MP0002132_abnormal_respiratory_system	1.04302309
67	MP0004142_abnormal_muscle_tone	1.03421426
68	MP0001486_abnormal_startle_reflex	1.03408499
69	MP0004043_abnormal_pH_regulation	1.02744421
70	MP0002735_abnormal_chemical_nociception	1.02643785
71	MP0006292_abnormal_olfactory_placode	1.01526849
72	MP0000653_abnormal_sex_gland	1.00131738
73	MP0001145_abnormal_male_reproductive	0.97273825
74	MP0001970_abnormal_pain_threshold	0.95610599
75	MP0004133_heterotaxia	0.95481167
76	MP0002723_abnormal_immune_serum	0.94915644
77	MP0005084_abnormal_gallbladder_morpholo	0.94785176
78	MP0002736_abnormal_nociception_after	0.94407179
79	MP0003045_fibrosis	0.92371174
80	MP0002272_abnormal_nervous_system	0.91770592
81	MP0003724_increased_susceptibility_to	0.90697905
82	MP0006082_CNS_inflammation	0.90040176
83	MP0002572_abnormal_emotion/affect_behav	0.88635355
84	MP0002229_neurodegeneration	0.86780377
85	MP0002452_abnormal_antigen_presenting	0.86522432
86	MP0005310_abnormal_salivary_gland	0.86503809
87	MP0003718_maternal_effect	0.85523085
88	MP0000538_abnormal_urinary_bladder	0.84644061
89	MP0005670_abnormal_white_adipose	0.83009602
90	MP0002733_abnormal_thermal_nociception	0.82890084
91	MP0000631_abnormal_neuroendocrine_gland	0.82814333
92	MP0002064_seizures	0.80347125
93	MP0002161_abnormal_fertility/fecundity	0.79879747
94	MP0004924_abnormal_behavior	0.79407991
95	MP0005386_behavior/neurological_phenoty	0.79407991
96	MP0005000_abnormal_immune_tolerance	0.78389959
97	MP0000470_abnormal_stomach_morphology	0.78309859
98	MP0002067_abnormal_sensory_capabilities	0.78121987
99	MP0006276_abnormal_autonomic_nervous	0.77544217
100	MP0006036_abnormal_mitochondrial_physio	0.76278876

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.31139506
2	Pancreatic cysts (HP:0001737)	4.20437514
3	Pancreatic fibrosis (HP:0100732)	4.18314317
4	Molar tooth sign on MRI (HP:0002419)	3.89988801
5	Abnormality of midbrain morphology (HP:0002418)	3.89988801
6	Type II lissencephaly (HP:0007260)	3.85734336
7	True hermaphroditism (HP:0010459)	3.74036945
8	Nephronophthisis (HP:0000090)	3.67652298
9	Attenuation of retinal blood vessels (HP:0007843)	3.51735348
10	Chronic hepatic failure (HP:0100626)	3.44059194
11	Abnormal rod and cone electroretinograms (HP:0008323)	3.34798667
12	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.16445108
13	Absent/shortened dynein arms (HP:0200106)	3.16445108
14	Cerebellar dysplasia (HP:0007033)	3.15897911
15	Abnormality of the renal medulla (HP:0100957)	3.15247135
16	Cystic liver disease (HP:0006706)	2.96416309
17	Polydipsia (HP:0001959)	2.90915538
18	Abnormal drinking behavior (HP:0030082)	2.90915538
19	Abolished electroretinogram (ERG) (HP:0000550)	2.87779745
20	Severe visual impairment (HP:0001141)	2.82657305
21	Pendular nystagmus (HP:0012043)	2.65170750
22	Abnormality of the renal cortex (HP:0011035)	2.64930861
23	Male pseudohermaphroditism (HP:0000037)	2.61268314
24	Decreased central vision (HP:0007663)	2.60925868
25	Hyperventilation (HP:0002883)	2.55184716
26	Tubular atrophy (HP:0000092)	2.52427415
27	Inability to walk (HP:0002540)	2.52166742
28	Bony spicule pigmentary retinopathy (HP:0007737)	2.51470655
29	Anencephaly (HP:0002323)	2.50241538
30	Protruding tongue (HP:0010808)	2.49389631
31	Medial flaring of the eyebrow (HP:0010747)	2.45083125
32	Retinal dysplasia (HP:0007973)	2.44602902
33	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.42591293
34	Congenital hepatic fibrosis (HP:0002612)	2.42250104
35	Hypothermia (HP:0002045)	2.40722908
36	Tubulointerstitial nephritis (HP:0001970)	2.40672434
37	Abnormal biliary tract physiology (HP:0012439)	2.39002748
38	Bile duct proliferation (HP:0001408)	2.39002748
39	Gaze-evoked nystagmus (HP:0000640)	2.37574700
40	Keratoconus (HP:0000563)	2.37555833
41	Increased corneal curvature (HP:0100692)	2.37555833
42	Clumsiness (HP:0002312)	2.37313891
43	Absent speech (HP:0001344)	2.35461278
44	Abnormal ciliary motility (HP:0012262)	2.35098640
45	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.34245165
46	Abnormal respiratory epithelium morphology (HP:0012253)	2.28907045
47	Abnormal respiratory motile cilium morphology (HP:0005938)	2.28907045
48	Thyroiditis (HP:0100646)	2.24389791
49	Polyuria (HP:0000103)	2.16536708
50	Occipital encephalocele (HP:0002085)	2.14927791
51	Sclerocornea (HP:0000647)	2.14155034
52	Abnormality of macular pigmentation (HP:0008002)	2.12679391
53	Broad-based gait (HP:0002136)	2.08414947
54	Fair hair (HP:0002286)	2.08119680
55	Progressive cerebellar ataxia (HP:0002073)	2.05837190
56	Abnormality of B cell number (HP:0010975)	2.01260309
57	Ketosis (HP:0001946)	1.98097172
58	Abnormal respiratory motile cilium physiology (HP:0012261)	1.97985078
59	Lissencephaly (HP:0001339)	1.97553867
60	Absent thumb (HP:0009777)	1.97513235
61	Stomatitis (HP:0010280)	1.96276829
62	Progressive inability to walk (HP:0002505)	1.95634476
63	Genetic anticipation (HP:0003743)	1.95582584
64	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.95530284
65	Albinism (HP:0001022)	1.94890415
66	Postaxial foot polydactyly (HP:0001830)	1.94851598
67	Large for gestational age (HP:0001520)	1.93801849
68	Macular degeneration (HP:0000608)	1.86718130
69	Widely spaced teeth (HP:0000687)	1.86558878
70	Pachygyria (HP:0001302)	1.85874060
71	Hypoplasia of the pons (HP:0012110)	1.85829579
72	Optic nerve hypoplasia (HP:0000609)	1.84853203
73	Abnormality of the pons (HP:0007361)	1.83550025
74	Abnormal urine output (HP:0012590)	1.83158334
75	Congenital sensorineural hearing impairment (HP:0008527)	1.81386397
76	Furrowed tongue (HP:0000221)	1.80740587
77	Hypoplasia of the uterus (HP:0000013)	1.78929919
78	Febrile seizures (HP:0002373)	1.76314405
79	Photophobia (HP:0000613)	1.75958679
80	Mitochondrial inheritance (HP:0001427)	1.75159085
81	Neoplasm of the adrenal cortex (HP:0100641)	1.73942338
82	Hypoalbuminemia (HP:0003073)	1.72940786
83	Abnormal albumin level (HP:0012116)	1.72940786
84	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.72620843
85	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.72092645
86	Gait imbalance (HP:0002141)	1.72055359
87	Chorioretinal atrophy (HP:0000533)	1.71987439
88	Abnormal protein glycosylation (HP:0012346)	1.71447656
89	Abnormal glycosylation (HP:0012345)	1.71447656
90	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.71447656
91	Abnormal protein N-linked glycosylation (HP:0012347)	1.71447656
92	Optic disc pallor (HP:0000543)	1.71244099
93	Increased CSF lactate (HP:0002490)	1.70842435
94	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.68236455
95	Aplasia/hypoplasia of the uterus (HP:0008684)	1.67333788
96	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.65512975
97	Retrobulbar optic neuritis (HP:0100654)	1.65232527
98	Optic neuritis (HP:0100653)	1.65232527
99	Tubulointerstitial abnormality (HP:0001969)	1.65100807
100	Congenital primary aphakia (HP:0007707)	1.62659264

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.27004046
2	PINK1	4.72715002
3	BMPR1B	3.35876922
4	TLK1	3.18044470
5	ADRBK2	3.10016028
6	ACVR1B	3.00468189
7	MAP4K2	3.00169510
8	ZAK	2.98070030
9	MARK3	2.42259204
10	GRK1	2.30393418
11	WNK4	1.98178878
12	INSRR	1.95928025
13	NUAK1	1.60320109
14	MAPK13	1.60250217
15	TXK	1.59024555
16	TAOK3	1.55615673
17	WNK3	1.34369853
18	MAP2K7	1.27674051
19	KIT	1.25177287
20	GRK7	1.21905603
21	OXSR1	1.12975460
22	MAP4K1	1.11956282
23	MAPKAPK3	1.11838100
24	DAPK2	1.08849075
25	CAMKK2	1.06736510
26	RPS6KA5	1.05701651
27	MAP3K4	1.01340131
28	PTK2B	1.01033094
29	IKBKB	0.96216662
30	PRKCQ	0.92438231
31	STK38L	0.91885979
32	ADRBK1	0.90734344
33	CSNK1A1L	0.89681655
34	CSNK1G3	0.87692588
35	PLK2	0.85623778
36	MAPK15	0.81683599
37	TGFBR1	0.81440275
38	SYK	0.80131869
39	CASK	0.79911359
40	CSNK1G2	0.79715999
41	DYRK2	0.79547900
42	PAK3	0.78076297
43	STK39	0.78016783
44	CSNK1G1	0.77219273
45	CAMK1G	0.73059036
46	CSF1R	0.73054482
47	PKN1	0.71857420
48	STK38	0.70358195
49	NEK2	0.69925552
50	BLK	0.69640123
51	TEC	0.68437714
52	TNK2	0.67895672
53	PRKCE	0.67150084
54	PLK4	0.65958834
55	PRKAA2	0.64878317
56	FGFR2	0.63913376
57	FES	0.63720021
58	CAMK1D	0.63432929
59	CAMK1	0.61310753
60	MUSK	0.60299443
61	ITK	0.55763341
62	PHKG1	0.53780019
63	PHKG2	0.53780019
64	BTK	0.52388171
65	PIK3CG	0.52166096
66	OBSCN	0.51941191
67	STK11	0.51740238
68	EIF2AK3	0.51490213
69	LYN	0.51112590
70	VRK1	0.50939297
71	BCKDK	0.49256001
72	PRKCG	0.49152431
73	CHUK	0.47615253
74	MKNK2	0.47264313
75	PRKCI	0.46696628
76	WNK1	0.46537504
77	TIE1	0.46276243
78	MAP2K6	0.46158783
79	IKBKE	0.45244539
80	NLK	0.42017373
81	FLT3	0.39391681
82	PRKAA1	0.39050682
83	PDK1	0.37909573
84	PRKG1	0.37586166
85	CSNK1A1	0.36152091
86	SIK2	0.35617883
87	MATK	0.34872852
88	IRAK1	0.33991970
89	TRPM7	0.33310277
90	CDK3	0.32887571
91	LCK	0.32639433
92	PRKACA	0.30624941
93	PNCK	0.30279987
94	MYLK	0.28393413
95	SGK223	0.27980023
96	SGK494	0.27980023
97	PRKCZ	0.26854192
98	ABL1	0.26147056
99	PRKD3	0.25628426
100	ROCK1	0.24566949

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.84915209
2	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.66395140
3	Butanoate metabolism_Homo sapiens_hsa00650	2.46635358
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.44951347
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.38154142
6	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.24208777
7	Asthma_Homo sapiens_hsa05310	2.18806488
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.16170748
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.15427605
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.14158828
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.05470893
12	Olfactory transduction_Homo sapiens_hsa04740	2.05271835
13	Linoleic acid metabolism_Homo sapiens_hsa00591	2.02348990
14	Allograft rejection_Homo sapiens_hsa05330	1.92980980
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.85044014
16	Graft-versus-host disease_Homo sapiens_hsa05332	1.82990006
17	Type I diabetes mellitus_Homo sapiens_hsa04940	1.79399036
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.75379064
19	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.71081590
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.70094045
21	Caffeine metabolism_Homo sapiens_hsa00232	1.58866509
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.58031407
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.56460647
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.50600741
25	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.42698620
26	Homologous recombination_Homo sapiens_hsa03440	1.42441583
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.41498006
28	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.34036755
29	Rheumatoid arthritis_Homo sapiens_hsa05323	1.31431017
30	RNA polymerase_Homo sapiens_hsa03020	1.27652008
31	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.25458680
32	Basal transcription factors_Homo sapiens_hsa03022	1.19100393
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.17119872
34	Peroxisome_Homo sapiens_hsa04146	1.16161347
35	Selenocompound metabolism_Homo sapiens_hsa00450	1.14705461
36	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.14534290
37	ABC transporters_Homo sapiens_hsa02010	1.14104369
38	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.13195417
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.12575163
40	Fanconi anemia pathway_Homo sapiens_hsa03460	1.12042135
41	Regulation of autophagy_Homo sapiens_hsa04140	1.09852025
42	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.09737716
43	Taste transduction_Homo sapiens_hsa04742	1.08822606
44	Propanoate metabolism_Homo sapiens_hsa00640	1.08730829
45	Chemical carcinogenesis_Homo sapiens_hsa05204	1.07411682
46	Oxidative phosphorylation_Homo sapiens_hsa00190	1.01599730
47	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.94540429
48	Collecting duct acid secretion_Homo sapiens_hsa04966	0.94321097
49	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.90623535
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.89860875
51	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.87721699
52	Calcium signaling pathway_Homo sapiens_hsa04020	0.84434491
53	Nicotine addiction_Homo sapiens_hsa05033	0.80694475
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79824556
55	Morphine addiction_Homo sapiens_hsa05032	0.78557684
56	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.78160193
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.77467663
58	RNA degradation_Homo sapiens_hsa03018	0.76254365
59	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.70611667
60	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.70202874
61	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.70138568
62	Fatty acid degradation_Homo sapiens_hsa00071	0.68416597
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67991959
64	Antigen processing and presentation_Homo sapiens_hsa04612	0.66484687
65	Salivary secretion_Homo sapiens_hsa04970	0.65620220
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64346527
67	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.64259270
68	Parkinsons disease_Homo sapiens_hsa05012	0.63745447
69	Retinol metabolism_Homo sapiens_hsa00830	0.63508147
70	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.63482276
71	Purine metabolism_Homo sapiens_hsa00230	0.63198175
72	Phagosome_Homo sapiens_hsa04145	0.62653866
73	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.61094385
74	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.61017898
75	Circadian entrainment_Homo sapiens_hsa04713	0.60437148
76	Lysosome_Homo sapiens_hsa04142	0.59447894
77	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.58666044
78	Sphingolipid metabolism_Homo sapiens_hsa00600	0.56881138
79	Serotonergic synapse_Homo sapiens_hsa04726	0.53942182
80	Insulin secretion_Homo sapiens_hsa04911	0.51134438
81	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.49986396
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49936503
83	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.49468344
84	Glutamatergic synapse_Homo sapiens_hsa04724	0.49463579
85	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.47351303
86	Circadian rhythm_Homo sapiens_hsa04710	0.46674321
87	Tuberculosis_Homo sapiens_hsa05152	0.44743038
88	African trypanosomiasis_Homo sapiens_hsa05143	0.44270526
89	Huntingtons disease_Homo sapiens_hsa05016	0.43389839
90	Mineral absorption_Homo sapiens_hsa04978	0.43170028
91	Metabolic pathways_Homo sapiens_hsa01100	0.42894181
92	Sulfur relay system_Homo sapiens_hsa04122	0.41983906
93	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.41741143
94	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.40935098
95	GABAergic synapse_Homo sapiens_hsa04727	0.40395405
96	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.39537212
97	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.38173647
98	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37919983
99	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.36215399
100	Renin secretion_Homo sapiens_hsa04924	0.35329243

LINC00854

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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