ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein localization to cilium (GO:0061512)	4.00337289
2	behavioral response to nicotine (GO:0035095)	3.82700199
3	presynaptic membrane assembly (GO:0097105)	3.57697811
4	presynaptic membrane organization (GO:0097090)	3.54965739
5	protein complex biogenesis (GO:0070271)	3.45623006
6	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.41657993
7	pyrimidine nucleobase catabolic process (GO:0006208)	3.38659880
8	regulation of hexokinase activity (GO:1903299)	3.30624831
9	regulation of glucokinase activity (GO:0033131)	3.30624831
10	mitochondrial respiratory chain complex assembly (GO:0033108)	3.29923169
11	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.29680534
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.24928190
13	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.22254328
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.22254328
15	NADH dehydrogenase complex assembly (GO:0010257)	3.22254328
16	somite rostral/caudal axis specification (GO:0032525)	3.04796497
17	protein-cofactor linkage (GO:0018065)	2.98752666
18	intraciliary transport (GO:0042073)	2.95542332
19	dendritic spine morphogenesis (GO:0060997)	2.93270606
20	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.92822712
21	ATP synthesis coupled proton transport (GO:0015986)	2.92822712
22	respiratory chain complex IV assembly (GO:0008535)	2.88792278
23	regulation of mesoderm development (GO:2000380)	2.88742567
24	postsynaptic membrane organization (GO:0001941)	2.82698860
25	proteasome assembly (GO:0043248)	2.79289062
26	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.79000249
27	epithelial cilium movement (GO:0003351)	2.76928246
28	nucleobase catabolic process (GO:0046113)	2.76887209
29	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.76807175
30	DNA double-strand break processing (GO:0000729)	2.76270018
31	protein localization to synapse (GO:0035418)	2.76067829
32	water-soluble vitamin biosynthetic process (GO:0042364)	2.74431790
33	nonmotile primary cilium assembly (GO:0035058)	2.74233691
34	platelet dense granule organization (GO:0060155)	2.74188935
35	positive regulation of gastrulation (GO:2000543)	2.72008704
36	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.70913662
37	limb bud formation (GO:0060174)	2.69168842
38	protein neddylation (GO:0045116)	2.66821287
39	DNA damage response, detection of DNA damage (GO:0042769)	2.65968784
40	negative regulation of activin receptor signaling pathway (GO:0032926)	2.64688958
41	cullin deneddylation (GO:0010388)	2.62118963
42	retinal ganglion cell axon guidance (GO:0031290)	2.61752892
43	respiratory electron transport chain (GO:0022904)	2.60971942
44	response to pheromone (GO:0019236)	2.60408643
45	electron transport chain (GO:0022900)	2.58793977
46	neuron cell-cell adhesion (GO:0007158)	2.58494742
47	protein prenylation (GO:0018342)	2.56490322
48	prenylation (GO:0097354)	2.56490322
49	cytochrome complex assembly (GO:0017004)	2.55381844
50	protein deneddylation (GO:0000338)	2.55192237
51	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.55071476
52	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.54616856
53	histone H2A acetylation (GO:0043968)	2.54483842
54	regulation of coenzyme metabolic process (GO:0051196)	2.53431728
55	regulation of cofactor metabolic process (GO:0051193)	2.53431728
56	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.50970335
57	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.50458555
58	kidney morphogenesis (GO:0060993)	2.50276478
59	neuron fate determination (GO:0048664)	2.49253639
60	chaperone-mediated protein transport (GO:0072321)	2.49246441
61	chromatin remodeling at centromere (GO:0031055)	2.42546361
62	regulation of mitotic spindle checkpoint (GO:1903504)	2.42136148
63	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.42136148
64	DNA integration (GO:0015074)	2.41581105
65	inositol phosphate catabolic process (GO:0071545)	2.41095946
66	CENP-A containing nucleosome assembly (GO:0034080)	2.36552907
67	cilium organization (GO:0044782)	2.35234886
68	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.35172845
69	DNA deamination (GO:0045006)	2.33969853
70	cilium assembly (GO:0042384)	2.33825286
71	sequestering of actin monomers (GO:0042989)	2.32382106
72	cellular ketone body metabolic process (GO:0046950)	2.30438230
73	regulation of mitochondrial translation (GO:0070129)	2.30099645
74	prostate gland growth (GO:0060736)	2.29979959
75	spinal cord motor neuron differentiation (GO:0021522)	2.27882673
76	mannosylation (GO:0097502)	2.27697683
77	auditory behavior (GO:0031223)	2.27171766
78	cilium morphogenesis (GO:0060271)	2.24887982
79	negative regulation of axon guidance (GO:1902668)	2.24151370
80	cerebral cortex radially oriented cell migration (GO:0021799)	2.23914777
81	somite development (GO:0061053)	2.23675617
82	replication fork processing (GO:0031297)	2.22778445
83	histone exchange (GO:0043486)	2.22721657
84	centriole replication (GO:0007099)	2.19628109
85	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.18081899
86	substrate-independent telencephalic tangential migration (GO:0021826)	2.18081899
87	reflex (GO:0060004)	2.17405122
88	retinal cone cell development (GO:0046549)	2.16925109
89	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.16580220
90	synaptic transmission, cholinergic (GO:0007271)	2.16120583
91	thalamus development (GO:0021794)	2.16015729
92	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.15687380
93	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.15687380
94	termination of RNA polymerase III transcription (GO:0006386)	2.15505280
95	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.15505280
96	regulation of cilium movement (GO:0003352)	2.15403029
97	regulation of collateral sprouting (GO:0048670)	2.15362877
98	negative regulation of telomere maintenance (GO:0032205)	2.14440038
99	otic vesicle formation (GO:0030916)	2.14153082
100	regulation of timing of cell differentiation (GO:0048505)	2.13743669

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	2.95968982
2	EZH2_22144423_ChIP-Seq_EOC_Human	2.81414164
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.77159199
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.75744713
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.66430891
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.57311037
7	VDR_22108803_ChIP-Seq_LS180_Human	2.51712169
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.51413853
9	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.47719094
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.36184735
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.33586173
12	FUS_26573619_Chip-Seq_HEK293_Human	2.31243708
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.29881103
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.22107175
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.21921141
16	EWS_26573619_Chip-Seq_HEK293_Human	2.19218321
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.14666257
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.14527198
19	P300_19829295_ChIP-Seq_ESCs_Human	2.08505124
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.08212354
21	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.94362611
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.93716083
23	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.90623779
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89091177
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.86037758
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.84810922
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.78301231
28	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.77812369
29	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.69626254
30	RNF2_27304074_Chip-Seq_NSC_Mouse	1.63739342
31	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.58814074
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53460763
33	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.51673654
34	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.49378705
35	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.48943063
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47661479
37	ER_23166858_ChIP-Seq_MCF-7_Human	1.46856611
38	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.46659630
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46608661
40	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.44008987
41	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.41731016
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41707481
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.41200769
44	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38548818
45	MYC_18940864_ChIP-ChIP_HL60_Human	1.37840480
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.37533856
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.37396383
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.36435705
49	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.36261650
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.30817580
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.30817580
52	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.30413369
53	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.29744247
54	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.27832233
55	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.27267999
56	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.25418800
57	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.24465976
58	AR_25329375_ChIP-Seq_VCAP_Human	1.23810227
59	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.23745203
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.22998494
61	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.20294324
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20168548
63	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.19754383
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18997886
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18997886
66	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18296783
67	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.18296783
68	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16932578
69	VDR_23849224_ChIP-Seq_CD4+_Human	1.15442841
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.15299376
71	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.15262148
72	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.14935369
73	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.14527090
74	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.14327474
75	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.13142744
76	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.12940154
77	STAT3_23295773_ChIP-Seq_U87_Human	1.12689733
78	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.12651989
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11017091
80	REST_21632747_ChIP-Seq_MESCs_Mouse	1.10237836
81	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.08632922
82	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.07506555
83	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07015050
84	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05670051
85	TCF4_23295773_ChIP-Seq_U87_Human	1.05405415
86	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05259666
87	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.04408880
88	TCF4_22108803_ChIP-Seq_LS180_Human	1.04340229
89	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.02107663
90	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.02034836
91	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.01662562
92	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.00821638
93	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.00659728
94	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.99822336
95	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.99615595
96	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.98607893
97	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.98565514
98	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.95609941
99	P53_22387025_ChIP-Seq_ESCs_Mouse	0.94844241
100	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.94593840

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.04509880
2	MP0003890_abnormal_embryonic-extraembry	2.86716943
3	MP0001529_abnormal_vocalization	2.60864822
4	MP0006292_abnormal_olfactory_placode	2.59810314
5	MP0002102_abnormal_ear_morphology	2.49893453
6	MP0008877_abnormal_DNA_methylation	2.36679766
7	MP0004133_heterotaxia	2.24582707
8	MP0002938_white_spotting	1.98267643
9	MP0002638_abnormal_pupillary_reflex	1.96282402
10	MP0009046_muscle_twitch	1.91259552
11	MP0006072_abnormal_retinal_apoptosis	1.89377917
12	MP0001984_abnormal_olfaction	1.89256920
13	MP0002837_dystrophic_cardiac_calcinosis	1.88277641
14	MP0004270_analgesia	1.86733181
15	MP0005423_abnormal_somatic_nervous	1.86351078
16	MP0006276_abnormal_autonomic_nervous	1.84529822
17	MP0000372_irregular_coat_pigmentation	1.82879624
18	MP0002822_catalepsy	1.78601923
19	MP0003122_maternal_imprinting	1.74148629
20	MP0002272_abnormal_nervous_system	1.70836572
21	MP0005394_taste/olfaction_phenotype	1.70419833
22	MP0005499_abnormal_olfactory_system	1.70419833
23	MP0005551_abnormal_eye_electrophysiolog	1.67278457
24	MP0004142_abnormal_muscle_tone	1.64786967
25	MP0000778_abnormal_nervous_system	1.63356285
26	MP0002736_abnormal_nociception_after	1.61457556
27	MP0003119_abnormal_digestive_system	1.57192686
28	MP0008789_abnormal_olfactory_epithelium	1.56468545
29	MP0005253_abnormal_eye_physiology	1.54938022
30	MP0003121_genomic_imprinting	1.52924030
31	MP0004215_abnormal_myocardial_fiber	1.51936868
32	MP0009745_abnormal_behavioral_response	1.51630579
33	MP0003787_abnormal_imprinting	1.50850581
34	MP0001968_abnormal_touch/_nociception	1.48807202
35	MP0002234_abnormal_pharynx_morphology	1.44684609
36	MP0002734_abnormal_mechanical_nocicepti	1.44600032
37	MP0001486_abnormal_startle_reflex	1.41430750
38	MP0010030_abnormal_orbit_morphology	1.38352693
39	MP0000631_abnormal_neuroendocrine_gland	1.38327589
40	MP0005187_abnormal_penis_morphology	1.35998546
41	MP0000569_abnormal_digit_pigmentation	1.32286309
42	MP0008058_abnormal_DNA_repair	1.31441578
43	MP0003937_abnormal_limbs/digits/tail_de	1.30564699
44	MP0003195_calcinosis	1.29783957
45	MP0002751_abnormal_autonomic_nervous	1.26939393
46	MP0001905_abnormal_dopamine_level	1.25683223
47	MP0004885_abnormal_endolymph	1.24550763
48	MP0001293_anophthalmia	1.23736067
49	MP0003136_yellow_coat_color	1.23310699
50	MP0002735_abnormal_chemical_nociception	1.21581072
51	MP0008995_early_reproductive_senescence	1.21397193
52	MP0002572_abnormal_emotion/affect_behav	1.20733399
53	MP0002064_seizures	1.19243479
54	MP0004145_abnormal_muscle_electrophysio	1.19048054
55	MP0003283_abnormal_digestive_organ	1.18953524
56	MP0003635_abnormal_synaptic_transmissio	1.18873163
57	MP0003567_abnormal_fetal_cardiomyocyte	1.18786082
58	MP0002557_abnormal_social/conspecific_i	1.18542697
59	MP0005084_abnormal_gallbladder_morpholo	1.15973882
60	MP0005386_behavior/neurological_phenoty	1.14238647
61	MP0004924_abnormal_behavior	1.14238647
62	MP0002067_abnormal_sensory_capabilities	1.09732545
63	MP0000049_abnormal_middle_ear	1.08411476
64	MP0002184_abnormal_innervation	1.07832376
65	MP0002752_abnormal_somatic_nervous	1.06118970
66	MP0004147_increased_porphyrin_level	1.05958349
67	MP0003137_abnormal_impulse_conducting	1.05209936
68	MP0001485_abnormal_pinna_reflex	1.03763198
69	MP0002160_abnormal_reproductive_system	1.02450532
70	MP0005646_abnormal_pituitary_gland	1.01723560
71	MP0002063_abnormal_learning/memory/cond	0.99327742
72	MP0002233_abnormal_nose_morphology	0.97540527
73	MP0005645_abnormal_hypothalamus_physiol	0.97426525
74	MP0004085_abnormal_heartbeat	0.96385218
75	MP0000955_abnormal_spinal_cord	0.96173123
76	MP0006035_abnormal_mitochondrial_morpho	0.95301610
77	MP0002163_abnormal_gland_morphology	0.95174070
78	MP0000647_abnormal_sebaceous_gland	0.94816836
79	MP0005367_renal/urinary_system_phenotyp	0.94422189
80	MP0000516_abnormal_urinary_system	0.94422189
81	MP0000026_abnormal_inner_ear	0.93638826
82	MP0003646_muscle_fatigue	0.93555270
83	MP0002882_abnormal_neuron_morphology	0.93496873
84	MP0004859_abnormal_synaptic_plasticity	0.90858547
85	MP0005195_abnormal_posterior_eye	0.90805332
86	MP0001970_abnormal_pain_threshold	0.89042287
87	MP0003938_abnormal_ear_development	0.85759202
88	MP0001986_abnormal_taste_sensitivity	0.85437856
89	MP0004742_abnormal_vestibular_system	0.84411899
90	MP0001286_abnormal_eye_development	0.83951278
91	MP0005379_endocrine/exocrine_gland_phen	0.82918334
92	MP0005391_vision/eye_phenotype	0.82867558
93	MP0000639_abnormal_adrenal_gland	0.81572170
94	MP0003315_abnormal_perineum_morphology	0.79981135
95	MP0003718_maternal_effect	0.78409509
96	MP0002210_abnormal_sex_determination	0.77901246
97	MP0008872_abnormal_physiological_respon	0.77701223
98	MP0000566_synostosis	0.76256330
99	MP0003011_delayed_dark_adaptation	0.76242992
100	MP0001963_abnormal_hearing_physiology	0.75982005

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.26268114
2	Pancreatic cysts (HP:0001737)	3.10417833
3	Progressive macrocephaly (HP:0004481)	3.03630773
4	Acute encephalopathy (HP:0006846)	2.98970584
5	Medial flaring of the eyebrow (HP:0010747)	2.97607834
6	True hermaphroditism (HP:0010459)	2.96404546
7	Limb dystonia (HP:0002451)	2.94624035
8	Pancreatic fibrosis (HP:0100732)	2.90445127
9	Mitochondrial inheritance (HP:0001427)	2.82207599
10	Abnormal mitochondria in muscle tissue (HP:0008316)	2.77707669
11	Molar tooth sign on MRI (HP:0002419)	2.75836158
12	Abnormality of midbrain morphology (HP:0002418)	2.75836158
13	Nephronophthisis (HP:0000090)	2.70701261
14	Intestinal atresia (HP:0011100)	2.69446296
15	Gait imbalance (HP:0002141)	2.65346455
16	Methylmalonic acidemia (HP:0002912)	2.63812695
17	Increased CSF lactate (HP:0002490)	2.62789522
18	Abnormality of the labia minora (HP:0012880)	2.54511296
19	Short tibia (HP:0005736)	2.51089971
20	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.50895735
21	Congenital primary aphakia (HP:0007707)	2.50567665
22	Hypothermia (HP:0002045)	2.46763820
23	Genital tract atresia (HP:0001827)	2.38775572
24	Hepatocellular necrosis (HP:0001404)	2.37608933
25	Vaginal atresia (HP:0000148)	2.35755890
26	Increased hepatocellular lipid droplets (HP:0006565)	2.32217297
27	Nephrogenic diabetes insipidus (HP:0009806)	2.28574171
28	Progressive inability to walk (HP:0002505)	2.27469745
29	Chronic hepatic failure (HP:0100626)	2.27001352
30	Focal motor seizures (HP:0011153)	2.24340573
31	Hepatic necrosis (HP:0002605)	2.22177939
32	Type II lissencephaly (HP:0007260)	2.18412644
33	Abnormality of the renal medulla (HP:0100957)	2.17815209
34	Lipid accumulation in hepatocytes (HP:0006561)	2.17193080
35	Optic nerve hypoplasia (HP:0000609)	2.14534627
36	Lissencephaly (HP:0001339)	2.14187687
37	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.12730692
38	Septo-optic dysplasia (HP:0100842)	2.12142955
39	Sclerocornea (HP:0000647)	2.08127734
40	Inability to walk (HP:0002540)	2.07502591
41	Double outlet right ventricle (HP:0001719)	2.07285142
42	Congenital malformation of the right heart (HP:0011723)	2.07285142
43	Retinal dysplasia (HP:0007973)	2.07128502
44	3-Methylglutaconic aciduria (HP:0003535)	2.06957587
45	Cerebral edema (HP:0002181)	2.06288327
46	Anencephaly (HP:0002323)	2.05850738
47	Methylmalonic aciduria (HP:0012120)	2.04445254
48	Renal cortical cysts (HP:0000803)	2.03347774
49	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.01612069
50	Drooling (HP:0002307)	1.99964568
51	Abnormality of the renal cortex (HP:0011035)	1.96734759
52	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.93205170
53	Abnormality of alanine metabolism (HP:0010916)	1.93205170
54	Hyperalaninemia (HP:0003348)	1.93205170
55	Optic disc pallor (HP:0000543)	1.89307303
56	Oligodactyly (hands) (HP:0001180)	1.88639763
57	Rhinitis (HP:0012384)	1.84508834
58	Postaxial hand polydactyly (HP:0001162)	1.81015731
59	Abnormal respiratory epithelium morphology (HP:0012253)	1.80026950
60	Abnormal respiratory motile cilium morphology (HP:0005938)	1.80026950
61	Increased serum pyruvate (HP:0003542)	1.79238594
62	Anophthalmia (HP:0000528)	1.79146759
63	Polyphagia (HP:0002591)	1.78866250
64	Abdominal situs inversus (HP:0003363)	1.78661288
65	Abnormality of abdominal situs (HP:0011620)	1.78661288
66	Delayed CNS myelination (HP:0002188)	1.76067392
67	Renal Fanconi syndrome (HP:0001994)	1.75650632
68	Abnormal ciliary motility (HP:0012262)	1.75464738
69	Male pseudohermaphroditism (HP:0000037)	1.74800259
70	Glycosuria (HP:0003076)	1.74697897
71	Abnormality of urine glucose concentration (HP:0011016)	1.74697897
72	Specific learning disability (HP:0001328)	1.74471213
73	Preaxial hand polydactyly (HP:0001177)	1.74009818
74	Broad-based gait (HP:0002136)	1.73532081
75	Abnormal respiratory motile cilium physiology (HP:0012261)	1.72031042
76	Poor coordination (HP:0002370)	1.71747134
77	Postaxial foot polydactyly (HP:0001830)	1.71661817
78	Lactic acidosis (HP:0003128)	1.71276411
79	Labial hypoplasia (HP:0000066)	1.70717087
80	Dialeptic seizures (HP:0011146)	1.69976807
81	Focal seizures (HP:0007359)	1.69675187
82	Excessive salivation (HP:0003781)	1.69243157
83	Cystic liver disease (HP:0006706)	1.69089382
84	Growth hormone deficiency (HP:0000824)	1.68839098
85	Febrile seizures (HP:0002373)	1.68401864
86	Abnormal pancreas size (HP:0012094)	1.67883307
87	Calf muscle hypertrophy (HP:0008981)	1.66791451
88	Tongue fasciculations (HP:0001308)	1.66067767
89	Abnormality of the fovea (HP:0000493)	1.65983470
90	Colon cancer (HP:0003003)	1.65537420
91	Increased serum lactate (HP:0002151)	1.64270220
92	Hyperglycinemia (HP:0002154)	1.63963299
93	Hepatoblastoma (HP:0002884)	1.63794219
94	Atonic seizures (HP:0010819)	1.62753891
95	Renal hypoplasia (HP:0000089)	1.62212236
96	Abolished electroretinogram (ERG) (HP:0000550)	1.61813175
97	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.60340057
98	Hypoplasia of the fovea (HP:0007750)	1.60340057
99	Hyperinsulinemic hypoglycemia (HP:0000825)	1.60041443
100	Congenital stationary night blindness (HP:0007642)	1.58858030

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.53653540
2	WNK3	3.43167785
3	FRK	3.10895808
4	TRIM28	3.01569812
5	MAP3K4	2.36568600
6	BMPR1B	2.24812878
7	CASK	2.18381216
8	MARK1	2.17247432
9	TNIK	2.14884746
10	ZAK	2.05066492
11	BCR	1.98229326
12	MAPK13	1.92514876
13	NEK1	1.83562664
14	ACVR1B	1.72187209
15	NUAK1	1.69714248
16	ERBB3	1.67993346
17	MAP2K7	1.64568604
18	PNCK	1.62803352
19	PINK1	1.60838307
20	PLK2	1.55189738
21	MKNK2	1.46103566
22	EIF2AK3	1.38604978
23	MST4	1.36908537
24	ADRBK2	1.36237767
25	PLK4	1.35941208
26	STK16	1.34828984
27	GRK1	1.32151726
28	DYRK2	1.29292822
29	WEE1	1.25098191
30	NTRK3	1.22678245
31	PHKG2	1.21999063
32	PHKG1	1.21999063
33	EPHA4	1.21104237
34	WNK4	1.19390875
35	INSRR	1.18428805
36	OBSCN	1.18079361
37	ERBB4	1.16016155
38	PAK3	1.14810997
39	SRPK1	1.13188790
40	PLK3	1.12154915
41	CSNK1G2	1.09246387
42	MKNK1	1.07642247
43	CSNK1G1	1.07185222
44	VRK1	1.03009776
45	CCNB1	1.02546342
46	TLK1	1.01610530
47	CSNK1G3	1.00682748
48	TAOK3	0.96782989
49	VRK2	0.94667530
50	NME1	0.93713022
51	BUB1	0.90923987
52	BCKDK	0.87777764
53	PRKCG	0.85291232
54	PDK2	0.85076181
55	MINK1	0.83918599
56	UHMK1	0.81836441
57	PRKCE	0.79869640
58	CSNK1A1L	0.78958689
59	FGFR2	0.78057867
60	BRSK2	0.75617779
61	OXSR1	0.74974573
62	PBK	0.74304520
63	MAP2K4	0.72159859
64	TSSK6	0.71204503
65	DYRK3	0.71143072
66	STK39	0.70513382
67	LIMK1	0.69825977
68	NEK2	0.69189927
69	CAMK2A	0.69170052
70	GRK7	0.68728333
71	TAF1	0.68695599
72	ADRBK1	0.68133158
73	STK38L	0.65657725
74	EPHB2	0.64355239
75	NTRK2	0.64061635
76	EIF2AK1	0.63027767
77	GRK5	0.62244201
78	TGFBR1	0.59857070
79	PLK1	0.58610444
80	CDC7	0.54127663
81	DAPK2	0.52695681
82	CAMK2D	0.52077191
83	DYRK1A	0.51146475
84	EIF2AK2	0.47968789
85	PKN1	0.47875140
86	MAP3K12	0.47039384
87	PRKD3	0.46854728
88	RPS6KA4	0.42982207
89	CAMK2B	0.42707870
90	PRKACA	0.41697981
91	RPS6KA5	0.40856326
92	CSNK1A1	0.40836365
93	MUSK	0.40560725
94	TIE1	0.39363360
95	CDK19	0.37716194
96	CDK3	0.37512993
97	CAMK4	0.36421288
98	BRD4	0.35640362
99	PRKACB	0.33949163
100	CDK5	0.33837352

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.20994436
2	Protein export_Homo sapiens_hsa03060	3.17448070
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.91012068
4	Parkinsons disease_Homo sapiens_hsa05012	2.78729701
5	Proteasome_Homo sapiens_hsa03050	2.20521037
6	Nicotine addiction_Homo sapiens_hsa05033	2.03819052
7	Propanoate metabolism_Homo sapiens_hsa00640	1.97130747
8	Butanoate metabolism_Homo sapiens_hsa00650	1.94988692
9	Huntingtons disease_Homo sapiens_hsa05016	1.85504467
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.84311947
11	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.78885224
12	Alzheimers disease_Homo sapiens_hsa05010	1.75765369
13	Phototransduction_Homo sapiens_hsa04744	1.75411358
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.73256306
15	RNA polymerase_Homo sapiens_hsa03020	1.72415501
16	Steroid biosynthesis_Homo sapiens_hsa00100	1.71502366
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.70732232
18	Basal transcription factors_Homo sapiens_hsa03022	1.66701663
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.62700750
20	Fatty acid elongation_Homo sapiens_hsa00062	1.56147018
21	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.54883606
22	RNA degradation_Homo sapiens_hsa03018	1.46846930
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.43022665
24	Homologous recombination_Homo sapiens_hsa03440	1.42150433
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.34459549
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.34015170
27	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.30187157
28	Mismatch repair_Homo sapiens_hsa03430	1.26597889
29	GABAergic synapse_Homo sapiens_hsa04727	1.25731445
30	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.23884648
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.21585413
32	Peroxisome_Homo sapiens_hsa04146	1.19405484
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.19309981
34	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.19207124
35	Pyruvate metabolism_Homo sapiens_hsa00620	1.16178414
36	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.11547993
37	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.10389914
38	Non-homologous end-joining_Homo sapiens_hsa03450	1.09779606
39	Taste transduction_Homo sapiens_hsa04742	1.08752511
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.05500850
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.05082398
42	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.05038360
43	Tryptophan metabolism_Homo sapiens_hsa00380	1.01769467
44	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.01087230
45	Collecting duct acid secretion_Homo sapiens_hsa04966	0.99443964
46	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.97769878
47	Regulation of autophagy_Homo sapiens_hsa04140	0.96820837
48	Linoleic acid metabolism_Homo sapiens_hsa00591	0.96814584
49	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.95118304
50	Morphine addiction_Homo sapiens_hsa05032	0.94341101
51	Nitrogen metabolism_Homo sapiens_hsa00910	0.91115638
52	Sulfur metabolism_Homo sapiens_hsa00920	0.90693783
53	Insulin secretion_Homo sapiens_hsa04911	0.90550842
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.90319178
55	Glutamatergic synapse_Homo sapiens_hsa04724	0.90179264
56	Circadian entrainment_Homo sapiens_hsa04713	0.88758207
57	RNA transport_Homo sapiens_hsa03013	0.88614857
58	Ribosome_Homo sapiens_hsa03010	0.87505027
59	Fat digestion and absorption_Homo sapiens_hsa04975	0.86230779
60	Folate biosynthesis_Homo sapiens_hsa00790	0.86154994
61	Spliceosome_Homo sapiens_hsa03040	0.85556378
62	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.83812263
63	Olfactory transduction_Homo sapiens_hsa04740	0.81961801
64	Basal cell carcinoma_Homo sapiens_hsa05217	0.81015392
65	Fatty acid metabolism_Homo sapiens_hsa01212	0.78978034
66	Ether lipid metabolism_Homo sapiens_hsa00565	0.78817581
67	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.76531910
68	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.76507749
69	Cocaine addiction_Homo sapiens_hsa05030	0.74765551
70	Purine metabolism_Homo sapiens_hsa00230	0.74161648
71	Nucleotide excision repair_Homo sapiens_hsa03420	0.73457685
72	Metabolic pathways_Homo sapiens_hsa01100	0.72440339
73	Dopaminergic synapse_Homo sapiens_hsa04728	0.67604881
74	Caffeine metabolism_Homo sapiens_hsa00232	0.66488560
75	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.65973664
76	Oocyte meiosis_Homo sapiens_hsa04114	0.63563465
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.62989162
78	Circadian rhythm_Homo sapiens_hsa04710	0.62372437
79	Serotonergic synapse_Homo sapiens_hsa04726	0.62335268
80	Fatty acid degradation_Homo sapiens_hsa00071	0.62320566
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60531828
82	Amphetamine addiction_Homo sapiens_hsa05031	0.58269240
83	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.58238423
84	Base excision repair_Homo sapiens_hsa03410	0.55641688
85	Glutathione metabolism_Homo sapiens_hsa00480	0.55433651
86	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.54937353
87	Pyrimidine metabolism_Homo sapiens_hsa00240	0.53345582
88	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.52635104
89	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.52076479
90	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.51304377
91	Chemical carcinogenesis_Homo sapiens_hsa05204	0.51081040
92	Alcoholism_Homo sapiens_hsa05034	0.49690281
93	Retinol metabolism_Homo sapiens_hsa00830	0.49400998
94	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.49379803
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49371006
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.48791194
97	One carbon pool by folate_Homo sapiens_hsa00670	0.48062340
98	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.46506747
99	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46284330
100	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.45874168

LINC00888

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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