LINC00888

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to cilium (GO:0061512)4.00337289
2behavioral response to nicotine (GO:0035095)3.82700199
3presynaptic membrane assembly (GO:0097105)3.57697811
4presynaptic membrane organization (GO:0097090)3.54965739
5protein complex biogenesis (GO:0070271)3.45623006
6establishment of protein localization to mitochondrial membrane (GO:0090151)3.41657993
7pyrimidine nucleobase catabolic process (GO:0006208)3.38659880
8regulation of hexokinase activity (GO:1903299)3.30624831
9regulation of glucokinase activity (GO:0033131)3.30624831
10mitochondrial respiratory chain complex assembly (GO:0033108)3.29923169
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.29680534
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.24928190
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.22254328
14mitochondrial respiratory chain complex I assembly (GO:0032981)3.22254328
15NADH dehydrogenase complex assembly (GO:0010257)3.22254328
16somite rostral/caudal axis specification (GO:0032525)3.04796497
17protein-cofactor linkage (GO:0018065)2.98752666
18intraciliary transport (GO:0042073)2.95542332
19dendritic spine morphogenesis (GO:0060997)2.93270606
20energy coupled proton transport, down electrochemical gradient (GO:0015985)2.92822712
21ATP synthesis coupled proton transport (GO:0015986)2.92822712
22respiratory chain complex IV assembly (GO:0008535)2.88792278
23regulation of mesoderm development (GO:2000380)2.88742567
24postsynaptic membrane organization (GO:0001941)2.82698860
25proteasome assembly (GO:0043248)2.79289062
26regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.79000249
27epithelial cilium movement (GO:0003351)2.76928246
28nucleobase catabolic process (GO:0046113)2.76887209
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.76807175
30DNA double-strand break processing (GO:0000729)2.76270018
31protein localization to synapse (GO:0035418)2.76067829
32water-soluble vitamin biosynthetic process (GO:0042364)2.74431790
33nonmotile primary cilium assembly (GO:0035058)2.74233691
34platelet dense granule organization (GO:0060155)2.74188935
35positive regulation of gastrulation (GO:2000543)2.72008704
36regulation of acyl-CoA biosynthetic process (GO:0050812)2.70913662
37limb bud formation (GO:0060174)2.69168842
38protein neddylation (GO:0045116)2.66821287
39DNA damage response, detection of DNA damage (GO:0042769)2.65968784
40negative regulation of activin receptor signaling pathway (GO:0032926)2.64688958
41cullin deneddylation (GO:0010388)2.62118963
42retinal ganglion cell axon guidance (GO:0031290)2.61752892
43respiratory electron transport chain (GO:0022904)2.60971942
44response to pheromone (GO:0019236)2.60408643
45electron transport chain (GO:0022900)2.58793977
46neuron cell-cell adhesion (GO:0007158)2.58494742
47protein prenylation (GO:0018342)2.56490322
48prenylation (GO:0097354)2.56490322
49cytochrome complex assembly (GO:0017004)2.55381844
50protein deneddylation (GO:0000338)2.55192237
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.55071476
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.54616856
53histone H2A acetylation (GO:0043968)2.54483842
54regulation of coenzyme metabolic process (GO:0051196)2.53431728
55regulation of cofactor metabolic process (GO:0051193)2.53431728
56G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50970335
57negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50458555
58kidney morphogenesis (GO:0060993)2.50276478
59neuron fate determination (GO:0048664)2.49253639
60chaperone-mediated protein transport (GO:0072321)2.49246441
61chromatin remodeling at centromere (GO:0031055)2.42546361
62regulation of mitotic spindle checkpoint (GO:1903504)2.42136148
63regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.42136148
64DNA integration (GO:0015074)2.41581105
65inositol phosphate catabolic process (GO:0071545)2.41095946
66CENP-A containing nucleosome assembly (GO:0034080)2.36552907
67cilium organization (GO:0044782)2.35234886
68negative regulation of transcription regulatory region DNA binding (GO:2000678)2.35172845
69DNA deamination (GO:0045006)2.33969853
70cilium assembly (GO:0042384)2.33825286
71sequestering of actin monomers (GO:0042989)2.32382106
72cellular ketone body metabolic process (GO:0046950)2.30438230
73regulation of mitochondrial translation (GO:0070129)2.30099645
74prostate gland growth (GO:0060736)2.29979959
75spinal cord motor neuron differentiation (GO:0021522)2.27882673
76mannosylation (GO:0097502)2.27697683
77auditory behavior (GO:0031223)2.27171766
78cilium morphogenesis (GO:0060271)2.24887982
79negative regulation of axon guidance (GO:1902668)2.24151370
80cerebral cortex radially oriented cell migration (GO:0021799)2.23914777
81somite development (GO:0061053)2.23675617
82replication fork processing (GO:0031297)2.22778445
83histone exchange (GO:0043486)2.22721657
84centriole replication (GO:0007099)2.19628109
85substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.18081899
86substrate-independent telencephalic tangential migration (GO:0021826)2.18081899
87reflex (GO:0060004)2.17405122
88retinal cone cell development (GO:0046549)2.16925109
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.16580220
90synaptic transmission, cholinergic (GO:0007271)2.16120583
91thalamus development (GO:0021794)2.16015729
92somatic diversification of immune receptors via somatic mutation (GO:0002566)2.15687380
93somatic hypermutation of immunoglobulin genes (GO:0016446)2.15687380
94termination of RNA polymerase III transcription (GO:0006386)2.15505280
95transcription elongation from RNA polymerase III promoter (GO:0006385)2.15505280
96regulation of cilium movement (GO:0003352)2.15403029
97regulation of collateral sprouting (GO:0048670)2.15362877
98negative regulation of telomere maintenance (GO:0032205)2.14440038
99otic vesicle formation (GO:0030916)2.14153082
100regulation of timing of cell differentiation (GO:0048505)2.13743669

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human2.95968982
2EZH2_22144423_ChIP-Seq_EOC_Human2.81414164
3ZNF274_21170338_ChIP-Seq_K562_Hela2.77159199
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.75744713
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66430891
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57311037
7VDR_22108803_ChIP-Seq_LS180_Human2.51712169
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.51413853
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.47719094
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.36184735
11IGF1R_20145208_ChIP-Seq_DFB_Human2.33586173
12FUS_26573619_Chip-Seq_HEK293_Human2.31243708
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.29881103
14TAF15_26573619_Chip-Seq_HEK293_Human2.22107175
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.21921141
16EWS_26573619_Chip-Seq_HEK293_Human2.19218321
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14666257
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14527198
19P300_19829295_ChIP-Seq_ESCs_Human2.08505124
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.08212354
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.94362611
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93716083
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90623779
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89091177
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.86037758
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84810922
27ELK1_19687146_ChIP-ChIP_HELA_Human1.78301231
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77812369
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.69626254
30RNF2_27304074_Chip-Seq_NSC_Mouse1.63739342
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58814074
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53460763
33SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51673654
34SMAD3_21741376_ChIP-Seq_EPCs_Human1.49378705
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48943063
36SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47661479
37ER_23166858_ChIP-Seq_MCF-7_Human1.46856611
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46659630
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46608661
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44008987
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41731016
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41707481
43SMAD4_21799915_ChIP-Seq_A2780_Human1.41200769
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38548818
45MYC_18940864_ChIP-ChIP_HL60_Human1.37840480
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37533856
47BCAT_22108803_ChIP-Seq_LS180_Human1.37396383
48IRF1_19129219_ChIP-ChIP_H3396_Human1.36435705
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36261650
50CBP_20019798_ChIP-Seq_JUKART_Human1.30817580
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30817580
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30413369
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29744247
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27832233
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27267999
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25418800
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.24465976
58AR_25329375_ChIP-Seq_VCAP_Human1.23810227
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.23745203
60TP53_22573176_ChIP-Seq_HFKS_Human1.22998494
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20294324
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20168548
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19754383
64SOX2_19829295_ChIP-Seq_ESCs_Human1.18997886
65NANOG_19829295_ChIP-Seq_ESCs_Human1.18997886
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18296783
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18296783
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16932578
69VDR_23849224_ChIP-Seq_CD4+_Human1.15442841
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.15299376
71CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15262148
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.14935369
73ETS1_20019798_ChIP-Seq_JURKAT_Human1.14527090
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14327474
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13142744
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12940154
77STAT3_23295773_ChIP-Seq_U87_Human1.12689733
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12651989
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11017091
80REST_21632747_ChIP-Seq_MESCs_Mouse1.10237836
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08632922
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07506555
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.07015050
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.05670051
85TCF4_23295773_ChIP-Seq_U87_Human1.05405415
86RUNX2_22187159_ChIP-Seq_PCA_Human1.05259666
87SOX2_16153702_ChIP-ChIP_HESCs_Human1.04408880
88TCF4_22108803_ChIP-Seq_LS180_Human1.04340229
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02107663
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.02034836
91NANOG_16153702_ChIP-ChIP_HESCs_Human1.01662562
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00821638
93E2F4_17652178_ChIP-ChIP_JURKAT_Human1.00659728
94FLI1_21867929_ChIP-Seq_TH2_Mouse0.99822336
95JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99615595
96SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98607893
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98565514
98TAL1_26923725_Chip-Seq_HPCs_Mouse0.95609941
99P53_22387025_ChIP-Seq_ESCs_Mouse0.94844241
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94593840

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.04509880
2MP0003890_abnormal_embryonic-extraembry2.86716943
3MP0001529_abnormal_vocalization2.60864822
4MP0006292_abnormal_olfactory_placode2.59810314
5MP0002102_abnormal_ear_morphology2.49893453
6MP0008877_abnormal_DNA_methylation2.36679766
7MP0004133_heterotaxia2.24582707
8MP0002938_white_spotting1.98267643
9MP0002638_abnormal_pupillary_reflex1.96282402
10MP0009046_muscle_twitch1.91259552
11MP0006072_abnormal_retinal_apoptosis1.89377917
12MP0001984_abnormal_olfaction1.89256920
13MP0002837_dystrophic_cardiac_calcinosis1.88277641
14MP0004270_analgesia1.86733181
15MP0005423_abnormal_somatic_nervous1.86351078
16MP0006276_abnormal_autonomic_nervous1.84529822
17MP0000372_irregular_coat_pigmentation1.82879624
18MP0002822_catalepsy1.78601923
19MP0003122_maternal_imprinting1.74148629
20MP0002272_abnormal_nervous_system1.70836572
21MP0005394_taste/olfaction_phenotype1.70419833
22MP0005499_abnormal_olfactory_system1.70419833
23MP0005551_abnormal_eye_electrophysiolog1.67278457
24MP0004142_abnormal_muscle_tone1.64786967
25MP0000778_abnormal_nervous_system1.63356285
26MP0002736_abnormal_nociception_after1.61457556
27MP0003119_abnormal_digestive_system1.57192686
28MP0008789_abnormal_olfactory_epithelium1.56468545
29MP0005253_abnormal_eye_physiology1.54938022
30MP0003121_genomic_imprinting1.52924030
31MP0004215_abnormal_myocardial_fiber1.51936868
32MP0009745_abnormal_behavioral_response1.51630579
33MP0003787_abnormal_imprinting1.50850581
34MP0001968_abnormal_touch/_nociception1.48807202
35MP0002234_abnormal_pharynx_morphology1.44684609
36MP0002734_abnormal_mechanical_nocicepti1.44600032
37MP0001486_abnormal_startle_reflex1.41430750
38MP0010030_abnormal_orbit_morphology1.38352693
39MP0000631_abnormal_neuroendocrine_gland1.38327589
40MP0005187_abnormal_penis_morphology1.35998546
41MP0000569_abnormal_digit_pigmentation1.32286309
42MP0008058_abnormal_DNA_repair1.31441578
43MP0003937_abnormal_limbs/digits/tail_de1.30564699
44MP0003195_calcinosis1.29783957
45MP0002751_abnormal_autonomic_nervous1.26939393
46MP0001905_abnormal_dopamine_level1.25683223
47MP0004885_abnormal_endolymph1.24550763
48MP0001293_anophthalmia1.23736067
49MP0003136_yellow_coat_color1.23310699
50MP0002735_abnormal_chemical_nociception1.21581072
51MP0008995_early_reproductive_senescence1.21397193
52MP0002572_abnormal_emotion/affect_behav1.20733399
53MP0002064_seizures1.19243479
54MP0004145_abnormal_muscle_electrophysio1.19048054
55MP0003283_abnormal_digestive_organ1.18953524
56MP0003635_abnormal_synaptic_transmissio1.18873163
57MP0003567_abnormal_fetal_cardiomyocyte1.18786082
58MP0002557_abnormal_social/conspecific_i1.18542697
59MP0005084_abnormal_gallbladder_morpholo1.15973882
60MP0005386_behavior/neurological_phenoty1.14238647
61MP0004924_abnormal_behavior1.14238647
62MP0002067_abnormal_sensory_capabilities1.09732545
63MP0000049_abnormal_middle_ear1.08411476
64MP0002184_abnormal_innervation1.07832376
65MP0002752_abnormal_somatic_nervous1.06118970
66MP0004147_increased_porphyrin_level1.05958349
67MP0003137_abnormal_impulse_conducting1.05209936
68MP0001485_abnormal_pinna_reflex1.03763198
69MP0002160_abnormal_reproductive_system1.02450532
70MP0005646_abnormal_pituitary_gland1.01723560
71MP0002063_abnormal_learning/memory/cond0.99327742
72MP0002233_abnormal_nose_morphology0.97540527
73MP0005645_abnormal_hypothalamus_physiol0.97426525
74MP0004085_abnormal_heartbeat0.96385218
75MP0000955_abnormal_spinal_cord0.96173123
76MP0006035_abnormal_mitochondrial_morpho0.95301610
77MP0002163_abnormal_gland_morphology0.95174070
78MP0000647_abnormal_sebaceous_gland0.94816836
79MP0005367_renal/urinary_system_phenotyp0.94422189
80MP0000516_abnormal_urinary_system0.94422189
81MP0000026_abnormal_inner_ear0.93638826
82MP0003646_muscle_fatigue0.93555270
83MP0002882_abnormal_neuron_morphology0.93496873
84MP0004859_abnormal_synaptic_plasticity0.90858547
85MP0005195_abnormal_posterior_eye0.90805332
86MP0001970_abnormal_pain_threshold0.89042287
87MP0003938_abnormal_ear_development0.85759202
88MP0001986_abnormal_taste_sensitivity0.85437856
89MP0004742_abnormal_vestibular_system0.84411899
90MP0001286_abnormal_eye_development0.83951278
91MP0005379_endocrine/exocrine_gland_phen0.82918334
92MP0005391_vision/eye_phenotype0.82867558
93MP0000639_abnormal_adrenal_gland0.81572170
94MP0003315_abnormal_perineum_morphology0.79981135
95MP0003718_maternal_effect0.78409509
96MP0002210_abnormal_sex_determination0.77901246
97MP0008872_abnormal_physiological_respon0.77701223
98MP0000566_synostosis0.76256330
99MP0003011_delayed_dark_adaptation0.76242992
100MP0001963_abnormal_hearing_physiology0.75982005

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.26268114
2Pancreatic cysts (HP:0001737)3.10417833
3Progressive macrocephaly (HP:0004481)3.03630773
4Acute encephalopathy (HP:0006846)2.98970584
5Medial flaring of the eyebrow (HP:0010747)2.97607834
6True hermaphroditism (HP:0010459)2.96404546
7Limb dystonia (HP:0002451)2.94624035
8Pancreatic fibrosis (HP:0100732)2.90445127
9Mitochondrial inheritance (HP:0001427)2.82207599
10Abnormal mitochondria in muscle tissue (HP:0008316)2.77707669
11Molar tooth sign on MRI (HP:0002419)2.75836158
12Abnormality of midbrain morphology (HP:0002418)2.75836158
13Nephronophthisis (HP:0000090)2.70701261
14Intestinal atresia (HP:0011100)2.69446296
15Gait imbalance (HP:0002141)2.65346455
16Methylmalonic acidemia (HP:0002912)2.63812695
17Increased CSF lactate (HP:0002490)2.62789522
18Abnormality of the labia minora (HP:0012880)2.54511296
19Short tibia (HP:0005736)2.51089971
20Aplasia/Hypoplasia of the tibia (HP:0005772)2.50895735
21Congenital primary aphakia (HP:0007707)2.50567665
22Hypothermia (HP:0002045)2.46763820
23Genital tract atresia (HP:0001827)2.38775572
24Hepatocellular necrosis (HP:0001404)2.37608933
25Vaginal atresia (HP:0000148)2.35755890
26Increased hepatocellular lipid droplets (HP:0006565)2.32217297
27Nephrogenic diabetes insipidus (HP:0009806)2.28574171
28Progressive inability to walk (HP:0002505)2.27469745
29Chronic hepatic failure (HP:0100626)2.27001352
30Focal motor seizures (HP:0011153)2.24340573
31Hepatic necrosis (HP:0002605)2.22177939
32Type II lissencephaly (HP:0007260)2.18412644
33Abnormality of the renal medulla (HP:0100957)2.17815209
34Lipid accumulation in hepatocytes (HP:0006561)2.17193080
35Optic nerve hypoplasia (HP:0000609)2.14534627
36Lissencephaly (HP:0001339)2.14187687
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.12730692
38Septo-optic dysplasia (HP:0100842)2.12142955
39Sclerocornea (HP:0000647)2.08127734
40Inability to walk (HP:0002540)2.07502591
41Double outlet right ventricle (HP:0001719)2.07285142
42Congenital malformation of the right heart (HP:0011723)2.07285142
43Retinal dysplasia (HP:0007973)2.07128502
443-Methylglutaconic aciduria (HP:0003535)2.06957587
45Cerebral edema (HP:0002181)2.06288327
46Anencephaly (HP:0002323)2.05850738
47Methylmalonic aciduria (HP:0012120)2.04445254
48Renal cortical cysts (HP:0000803)2.03347774
49Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01612069
50Drooling (HP:0002307)1.99964568
51Abnormality of the renal cortex (HP:0011035)1.96734759
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93205170
53Abnormality of alanine metabolism (HP:0010916)1.93205170
54Hyperalaninemia (HP:0003348)1.93205170
55Optic disc pallor (HP:0000543)1.89307303
56Oligodactyly (hands) (HP:0001180)1.88639763
57Rhinitis (HP:0012384)1.84508834
58Postaxial hand polydactyly (HP:0001162)1.81015731
59Abnormal respiratory epithelium morphology (HP:0012253)1.80026950
60Abnormal respiratory motile cilium morphology (HP:0005938)1.80026950
61Increased serum pyruvate (HP:0003542)1.79238594
62Anophthalmia (HP:0000528)1.79146759
63Polyphagia (HP:0002591)1.78866250
64Abdominal situs inversus (HP:0003363)1.78661288
65Abnormality of abdominal situs (HP:0011620)1.78661288
66Delayed CNS myelination (HP:0002188)1.76067392
67Renal Fanconi syndrome (HP:0001994)1.75650632
68Abnormal ciliary motility (HP:0012262)1.75464738
69Male pseudohermaphroditism (HP:0000037)1.74800259
70Glycosuria (HP:0003076)1.74697897
71Abnormality of urine glucose concentration (HP:0011016)1.74697897
72Specific learning disability (HP:0001328)1.74471213
73Preaxial hand polydactyly (HP:0001177)1.74009818
74Broad-based gait (HP:0002136)1.73532081
75Abnormal respiratory motile cilium physiology (HP:0012261)1.72031042
76Poor coordination (HP:0002370)1.71747134
77Postaxial foot polydactyly (HP:0001830)1.71661817
78Lactic acidosis (HP:0003128)1.71276411
79Labial hypoplasia (HP:0000066)1.70717087
80Dialeptic seizures (HP:0011146)1.69976807
81Focal seizures (HP:0007359)1.69675187
82Excessive salivation (HP:0003781)1.69243157
83Cystic liver disease (HP:0006706)1.69089382
84Growth hormone deficiency (HP:0000824)1.68839098
85Febrile seizures (HP:0002373)1.68401864
86Abnormal pancreas size (HP:0012094)1.67883307
87Calf muscle hypertrophy (HP:0008981)1.66791451
88Tongue fasciculations (HP:0001308)1.66067767
89Abnormality of the fovea (HP:0000493)1.65983470
90Colon cancer (HP:0003003)1.65537420
91Increased serum lactate (HP:0002151)1.64270220
92Hyperglycinemia (HP:0002154)1.63963299
93Hepatoblastoma (HP:0002884)1.63794219
94Atonic seizures (HP:0010819)1.62753891
95Renal hypoplasia (HP:0000089)1.62212236
96Abolished electroretinogram (ERG) (HP:0000550)1.61813175
97Aplasia/Hypoplasia of the fovea (HP:0008060)1.60340057
98Hypoplasia of the fovea (HP:0007750)1.60340057
99Hyperinsulinemic hypoglycemia (HP:0000825)1.60041443
100Congenital stationary night blindness (HP:0007642)1.58858030

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.53653540
2WNK33.43167785
3FRK3.10895808
4TRIM283.01569812
5MAP3K42.36568600
6BMPR1B2.24812878
7CASK2.18381216
8MARK12.17247432
9TNIK2.14884746
10ZAK2.05066492
11BCR1.98229326
12MAPK131.92514876
13NEK11.83562664
14ACVR1B1.72187209
15NUAK11.69714248
16ERBB31.67993346
17MAP2K71.64568604
18PNCK1.62803352
19PINK11.60838307
20PLK21.55189738
21MKNK21.46103566
22EIF2AK31.38604978
23MST41.36908537
24ADRBK21.36237767
25PLK41.35941208
26STK161.34828984
27GRK11.32151726
28DYRK21.29292822
29WEE11.25098191
30NTRK31.22678245
31PHKG21.21999063
32PHKG11.21999063
33EPHA41.21104237
34WNK41.19390875
35INSRR1.18428805
36OBSCN1.18079361
37ERBB41.16016155
38PAK31.14810997
39SRPK11.13188790
40PLK31.12154915
41CSNK1G21.09246387
42MKNK11.07642247
43CSNK1G11.07185222
44VRK11.03009776
45CCNB11.02546342
46TLK11.01610530
47CSNK1G31.00682748
48TAOK30.96782989
49VRK20.94667530
50NME10.93713022
51BUB10.90923987
52BCKDK0.87777764
53PRKCG0.85291232
54PDK20.85076181
55MINK10.83918599
56UHMK10.81836441
57PRKCE0.79869640
58CSNK1A1L0.78958689
59FGFR20.78057867
60BRSK20.75617779
61OXSR10.74974573
62PBK0.74304520
63MAP2K40.72159859
64TSSK60.71204503
65DYRK30.71143072
66STK390.70513382
67LIMK10.69825977
68NEK20.69189927
69CAMK2A0.69170052
70GRK70.68728333
71TAF10.68695599
72ADRBK10.68133158
73STK38L0.65657725
74EPHB20.64355239
75NTRK20.64061635
76EIF2AK10.63027767
77GRK50.62244201
78TGFBR10.59857070
79PLK10.58610444
80CDC70.54127663
81DAPK20.52695681
82CAMK2D0.52077191
83DYRK1A0.51146475
84EIF2AK20.47968789
85PKN10.47875140
86MAP3K120.47039384
87PRKD30.46854728
88RPS6KA40.42982207
89CAMK2B0.42707870
90PRKACA0.41697981
91RPS6KA50.40856326
92CSNK1A10.40836365
93MUSK0.40560725
94TIE10.39363360
95CDK190.37716194
96CDK30.37512993
97CAMK40.36421288
98BRD40.35640362
99PRKACB0.33949163
100CDK50.33837352

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.20994436
2Protein export_Homo sapiens_hsa030603.17448070
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.91012068
4Parkinsons disease_Homo sapiens_hsa050122.78729701
5Proteasome_Homo sapiens_hsa030502.20521037
6Nicotine addiction_Homo sapiens_hsa050332.03819052
7Propanoate metabolism_Homo sapiens_hsa006401.97130747
8Butanoate metabolism_Homo sapiens_hsa006501.94988692
9Huntingtons disease_Homo sapiens_hsa050161.85504467
10Maturity onset diabetes of the young_Homo sapiens_hsa049501.84311947
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.78885224
12Alzheimers disease_Homo sapiens_hsa050101.75765369
13Phototransduction_Homo sapiens_hsa047441.75411358
14Cardiac muscle contraction_Homo sapiens_hsa042601.73256306
15RNA polymerase_Homo sapiens_hsa030201.72415501
16Steroid biosynthesis_Homo sapiens_hsa001001.71502366
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70732232
18Basal transcription factors_Homo sapiens_hsa030221.66701663
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62700750
20Fatty acid elongation_Homo sapiens_hsa000621.56147018
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54883606
22RNA degradation_Homo sapiens_hsa030181.46846930
23Fanconi anemia pathway_Homo sapiens_hsa034601.43022665
24Homologous recombination_Homo sapiens_hsa034401.42150433
25Selenocompound metabolism_Homo sapiens_hsa004501.34459549
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34015170
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30187157
28Mismatch repair_Homo sapiens_hsa034301.26597889
29GABAergic synapse_Homo sapiens_hsa047271.25731445
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23884648
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21585413
32Peroxisome_Homo sapiens_hsa041461.19405484
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19309981
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19207124
35Pyruvate metabolism_Homo sapiens_hsa006201.16178414
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11547993
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10389914
38Non-homologous end-joining_Homo sapiens_hsa034501.09779606
39Taste transduction_Homo sapiens_hsa047421.08752511
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05500850
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.05082398
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05038360
43Tryptophan metabolism_Homo sapiens_hsa003801.01769467
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01087230
45Collecting duct acid secretion_Homo sapiens_hsa049660.99443964
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97769878
47Regulation of autophagy_Homo sapiens_hsa041400.96820837
48Linoleic acid metabolism_Homo sapiens_hsa005910.96814584
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95118304
50Morphine addiction_Homo sapiens_hsa050320.94341101
51Nitrogen metabolism_Homo sapiens_hsa009100.91115638
52Sulfur metabolism_Homo sapiens_hsa009200.90693783
53Insulin secretion_Homo sapiens_hsa049110.90550842
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.90319178
55Glutamatergic synapse_Homo sapiens_hsa047240.90179264
56Circadian entrainment_Homo sapiens_hsa047130.88758207
57RNA transport_Homo sapiens_hsa030130.88614857
58Ribosome_Homo sapiens_hsa030100.87505027
59Fat digestion and absorption_Homo sapiens_hsa049750.86230779
60Folate biosynthesis_Homo sapiens_hsa007900.86154994
61Spliceosome_Homo sapiens_hsa030400.85556378
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83812263
63Olfactory transduction_Homo sapiens_hsa047400.81961801
64Basal cell carcinoma_Homo sapiens_hsa052170.81015392
65Fatty acid metabolism_Homo sapiens_hsa012120.78978034
66Ether lipid metabolism_Homo sapiens_hsa005650.78817581
67Hedgehog signaling pathway_Homo sapiens_hsa043400.76531910
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76507749
69Cocaine addiction_Homo sapiens_hsa050300.74765551
70Purine metabolism_Homo sapiens_hsa002300.74161648
71Nucleotide excision repair_Homo sapiens_hsa034200.73457685
72Metabolic pathways_Homo sapiens_hsa011000.72440339
73Dopaminergic synapse_Homo sapiens_hsa047280.67604881
74Caffeine metabolism_Homo sapiens_hsa002320.66488560
75Synaptic vesicle cycle_Homo sapiens_hsa047210.65973664
76Oocyte meiosis_Homo sapiens_hsa041140.63563465
77beta-Alanine metabolism_Homo sapiens_hsa004100.62989162
78Circadian rhythm_Homo sapiens_hsa047100.62372437
79Serotonergic synapse_Homo sapiens_hsa047260.62335268
80Fatty acid degradation_Homo sapiens_hsa000710.62320566
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60531828
82Amphetamine addiction_Homo sapiens_hsa050310.58269240
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58238423
84Base excision repair_Homo sapiens_hsa034100.55641688
85Glutathione metabolism_Homo sapiens_hsa004800.55433651
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54937353
87Pyrimidine metabolism_Homo sapiens_hsa002400.53345582
88TGF-beta signaling pathway_Homo sapiens_hsa043500.52635104
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52076479
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51304377
91Chemical carcinogenesis_Homo sapiens_hsa052040.51081040
92Alcoholism_Homo sapiens_hsa050340.49690281
93Retinol metabolism_Homo sapiens_hsa008300.49400998
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49379803
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49371006
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48791194
97One carbon pool by folate_Homo sapiens_hsa006700.48062340
98Vitamin B6 metabolism_Homo sapiens_hsa007500.46506747
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.46284330
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45874168

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