ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	7.52278458
2	relaxation of smooth muscle (GO:0044557)	5.70845613
3	cGMP-mediated signaling (GO:0019934)	5.65046675
4	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	5.51613177
5	negative regulation of striated muscle cell apoptotic process (GO:0010664)	5.16622883
6	regulation of phosphoprotein phosphatase activity (GO:0043666)	5.14076363
7	coenzyme catabolic process (GO:0009109)	5.00439641
8	motile cilium assembly (GO:0044458)	4.85260703
9	activation of protein kinase B activity (GO:0032148)	4.74586708
10	positive regulation of catecholamine secretion (GO:0033605)	4.63804488
11	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	4.38468991
12	regulation of phospholipase A2 activity (GO:0032429)	4.21547522
13	paraxial mesoderm development (GO:0048339)	4.16389979
14	mRNA cleavage (GO:0006379)	4.10405953
15	cellular response to zinc ion (GO:0071294)	4.05990748
16	potassium ion export (GO:0071435)	4.01839145
17	sulfation (GO:0051923)	3.94865490
18	regulation of oxidative stress-induced neuron death (GO:1903203)	3.84979338
19	tongue development (GO:0043586)	3.82234346
20	diacylglycerol metabolic process (GO:0046339)	3.76218070
21	regulation of cardiac muscle cell apoptotic process (GO:0010665)	3.73259607
22	protein localization to cell surface (GO:0034394)	3.68747115
23	mesenchymal-epithelial cell signaling (GO:0060638)	3.61681360
24	positive regulation of glycolytic process (GO:0045821)	3.56638798
25	phospholipid efflux (GO:0033700)	3.52690647
26	positive regulation of protein kinase C signaling (GO:0090037)	3.51158316
27	serine family amino acid catabolic process (GO:0009071)	3.48211556
28	androgen biosynthetic process (GO:0006702)	3.40077114
29	indole-containing compound catabolic process (GO:0042436)	3.39267860
30	indolalkylamine catabolic process (GO:0046218)	3.39267860
31	tryptophan catabolic process (GO:0006569)	3.39267860
32	myofibril assembly (GO:0030239)	3.39166118
33	smooth muscle contraction (GO:0006939)	3.31986835
34	organic cation transport (GO:0015695)	3.30909688
35	omega-hydroxylase P450 pathway (GO:0097267)	3.25746332
36	genitalia morphogenesis (GO:0035112)	3.23849433
37	barbed-end actin filament capping (GO:0051016)	3.22632315
38	relaxation of muscle (GO:0090075)	3.20680736
39	adult heart development (GO:0007512)	3.20274385
40	regulation of striated muscle cell apoptotic process (GO:0010662)	3.19511042
41	urinary tract smooth muscle contraction (GO:0014848)	3.17995864
42	multicellular organism reproduction (GO:0032504)	3.11363989
43	regulation of protein activation cascade (GO:2000257)	3.09993977
44	ovulation from ovarian follicle (GO:0001542)	3.08368641
45	regulation of autophagic vacuole assembly (GO:2000785)	3.07902662
46	cardiac myofibril assembly (GO:0055003)	3.05210172
47	melanin biosynthetic process (GO:0042438)	3.04692647
48	cytoplasmic mRNA processing body assembly (GO:0033962)	3.01898102
49	cell migration involved in heart development (GO:0060973)	3.00209115
50	high-density lipoprotein particle remodeling (GO:0034375)	2.99228390
51	muscle fiber development (GO:0048747)	2.98687990
52	smooth muscle cell differentiation (GO:0051145)	2.97303583
53	regulation of complement activation (GO:0030449)	2.94882660
54	regulation of cardioblast differentiation (GO:0051890)	2.94672456
55	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	2.94593368
56	type B pancreatic cell development (GO:0003323)	2.93848346
57	glycogen metabolic process (GO:0005977)	2.93841500
58	complement activation, alternative pathway (GO:0006957)	2.92763939
59	extracellular matrix assembly (GO:0085029)	2.91708959
60	cellular glucan metabolic process (GO:0006073)	2.89344891
61	glucan metabolic process (GO:0044042)	2.89344891
62	negative regulation of lipase activity (GO:0060192)	2.88252292
63	negative regulation of JNK cascade (GO:0046329)	2.87142091
64	cardiac muscle hypertrophy (GO:0003300)	2.85376486
65	glutamine family amino acid catabolic process (GO:0009065)	2.84654182
66	DNA double-strand break processing (GO:0000729)	2.83718372
67	ethanol metabolic process (GO:0006067)	2.81542300
68	regulation of oxidative phosphorylation (GO:0002082)	2.80598083
69	regulation of dopamine secretion (GO:0014059)	2.79237719
70	regulation of triglyceride catabolic process (GO:0010896)	2.78870650
71	spermatid development (GO:0007286)	2.78498258
72	regulation of transforming growth factor beta2 production (GO:0032909)	2.78404565
73	regulation of cholesterol esterification (GO:0010872)	2.78369691
74	secondary metabolite biosynthetic process (GO:0044550)	2.77837764
75	histone H3-K36 demethylation (GO:0070544)	2.77271755
76	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.76659980
77	melanin metabolic process (GO:0006582)	2.76655825
78	negative regulation of protein activation cascade (GO:2000258)	2.76407594
79	uterus development (GO:0060065)	2.75361177
80	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.75131898
81	negative regulation of defense response to virus (GO:0050687)	2.73970616
82	ethanol oxidation (GO:0006069)	2.73630868
83	quaternary ammonium group transport (GO:0015697)	2.73289013
84	reverse cholesterol transport (GO:0043691)	2.71689867
85	myelination in peripheral nervous system (GO:0022011)	2.70080188
86	peripheral nervous system axon ensheathment (GO:0032292)	2.70080188
87	regulation of protein kinase C signaling (GO:0090036)	2.67469720
88	striated muscle hypertrophy (GO:0014897)	2.66656151
89	heme transport (GO:0015886)	2.66318653
90	oligosaccharide biosynthetic process (GO:0009312)	2.63548364
91	negative regulation of fatty acid biosynthetic process (GO:0045717)	2.63251123
92	Leydig cell differentiation (GO:0033327)	2.63242944
93	tryptophan metabolic process (GO:0006568)	2.62657626
94	definitive hemopoiesis (GO:0060216)	2.61349761
95	single fertilization (GO:0007338)	2.60536973
96	negative regulation of muscle cell apoptotic process (GO:0010656)	2.58954669
97	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.58793982
98	heterochromatin organization (GO:0070828)	2.58640482
99	cellular zinc ion homeostasis (GO:0006882)	2.58163180
100	binding of sperm to zona pellucida (GO:0007339)	2.57405864

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.85188760
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.30595696
3	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	5.10978879
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.99672745
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.61880647
6	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.39353607
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.97726115
8	VDR_22108803_ChIP-Seq_LS180_Human	2.67316016
9	AR_21572438_ChIP-Seq_LNCaP_Human	2.56086455
10	GATA1_22025678_ChIP-Seq_K562_Human	2.26893200
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.06917618
12	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.99221803
13	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.88243910
14	FUS_26573619_Chip-Seq_HEK293_Human	1.85009670
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.84524033
16	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.83925931
17	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.83925931
18	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.71286228
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.70746484
20	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.70459874
21	RXR_22108803_ChIP-Seq_LS180_Human	1.69666061
22	AHR_22903824_ChIP-Seq_MCF-7_Human	1.66775510
23	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.64187730
24	AR_21909140_ChIP-Seq_LNCAP_Human	1.63339781
25	P300_19829295_ChIP-Seq_ESCs_Human	1.62420421
26	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.61325285
27	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.56367692
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.54046200
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.53262227
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.53126279
31	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.52367915
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.49864850
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49174964
34	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.44073402
35	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.41896638
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.36047780
37	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33352544
38	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.31613220
39	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30773882
40	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.30722714
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.30444437
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.30444437
43	TP53_18474530_ChIP-ChIP_U2OS_Human	1.29302939
44	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.26495650
45	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.26495650
46	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26123244
47	CJUN_26792858_Chip-Seq_BT549_Human	1.25367975
48	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.25052241
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.23450594
50	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.21933036
51	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.18982243
52	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.18402517
53	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.16901298
54	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.16626539
55	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.14266437
56	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.13922758
57	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.13726096
58	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.12227047
59	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.10375111
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.08898269
61	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.06971611
62	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.06660205
63	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.06165979
64	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.05728827
65	TBL1_22424771_ChIP-Seq_293T_Human	1.05546837
66	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.05282106
67	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	1.04702882
68	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.03879735
69	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.03141988
70	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.01635820
71	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.01472390
72	RXR_22158963_ChIP-Seq_LIVER_Mouse	0.97824266
73	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.96011866
74	STAT3_23295773_ChIP-Seq_U87_Human	0.95357029
75	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.94386461
76	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.94203068
77	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.94034826
78	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.94034826
79	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.93566515
80	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.93393597
81	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.92336416
82	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.90969600
83	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.90535378
84	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.89754532
85	CDX2_22108803_ChIP-Seq_LS180_Human	0.89641971
86	AR_25329375_ChIP-Seq_VCAP_Human	0.89393983
87	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.89348057
88	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89115488
89	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.88376774
90	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.88330242
91	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.86969895
92	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.86624183
93	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.84351329
94	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.82681989
95	TCF4_23295773_ChIP-Seq_U87_Human	0.82582899
96	BRD4_25478319_ChIP-Seq_HGPS_Human	0.82533537
97	CLOCK_20551151_ChIP-Seq_293T_Human	0.81284128
98	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.80773930
99	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.80389979
100	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.80387940

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	5.82789862
2	MP0004272_abnormal_basement_membrane	3.90858009
3	MP0008004_abnormal_stomach_pH	3.68627618
4	MP0010368_abnormal_lymphatic_system	3.52495358
5	MP0009840_abnormal_foam_cell	3.23636417
6	MP0003315_abnormal_perineum_morphology	3.19501431
7	MP0004084_abnormal_cardiac_muscle	2.93288445
8	MP0003806_abnormal_nucleotide_metabolis	2.70006976
9	MP0009697_abnormal_copulation	2.62175658
10	MP0000462_abnormal_digestive_system	2.47106808
11	MP0002160_abnormal_reproductive_system	2.40607948
12	MP0002132_abnormal_respiratory_system	2.33574066
13	MP0005410_abnormal_fertilization	2.32402512
14	MP0005360_urolithiasis	2.20726950
15	MP0005171_absent_coat_pigmentation	2.18853743
16	MP0002127_abnormal_cardiovascular_syste	2.17022150
17	MP0004036_abnormal_muscle_relaxation	2.16168738
18	MP0000537_abnormal_urethra_morphology	2.11837619
19	MP0010386_abnormal_urinary_bladder	2.00096980
20	MP0005248_abnormal_Harderian_gland	1.99605059
21	MP0002102_abnormal_ear_morphology	1.93390325
22	MP0004264_abnormal_extraembryonic_tissu	1.89068838
23	MP0001661_extended_life_span	1.86114529
24	MP0008438_abnormal_cutaneous_collagen	1.84942580
25	MP0003385_abnormal_body_wall	1.79998946
26	MP0005409_darkened_coat_color	1.79654475
27	MP0009250_abnormal_appendicular_skeleto	1.72505678
28	MP0004145_abnormal_muscle_electrophysio	1.72021778
29	MP0005275_abnormal_skin_tensile	1.69538034
30	MP0002254_reproductive_system_inflammat	1.64827043
31	MP0004215_abnormal_myocardial_fiber	1.60537122
32	MP0005330_cardiomyopathy	1.59817330
33	MP0003567_abnormal_fetal_cardiomyocyte	1.55731335
34	MP0001664_abnormal_digestion	1.54956422
35	MP0005595_abnormal_vascular_smooth	1.52184359
36	MP0000538_abnormal_urinary_bladder	1.49010346
37	MP0003941_abnormal_skin_development	1.48918721
38	MP0000749_muscle_degeneration	1.46754127
39	MP0001958_emphysema	1.43907190
40	MP0002108_abnormal_muscle_morphology	1.42707545
41	MP0001984_abnormal_olfaction	1.41084241
42	MP0005620_abnormal_muscle_contractility	1.40987318
43	MP0001849_ear_inflammation	1.40918841
44	MP0002233_abnormal_nose_morphology	1.39956626
45	MP0003868_abnormal_feces_composition	1.38329613
46	MP0002249_abnormal_larynx_morphology	1.37846642
47	MP0005503_abnormal_tendon_morphology	1.36327681
48	MP0005187_abnormal_penis_morphology	1.34412462
49	MP0006072_abnormal_retinal_apoptosis	1.18286641
50	MP0003890_abnormal_embryonic-extraembry	1.17352987
51	MP0002295_abnormal_pulmonary_circulatio	1.14499833
52	MP0002115_abnormal_skeleton_extremities	1.09360882
53	MP0006138_congestive_heart_failure	1.07226472
54	MP0008775_abnormal_heart_ventricle	1.04263970
55	MP0000230_abnormal_systemic_arterial	1.02947712
56	MP0001188_hyperpigmentation	1.02092134
57	MP0002837_dystrophic_cardiac_calcinosis	0.98579800
58	MP0001756_abnormal_urination	0.98505755
59	MP0010630_abnormal_cardiac_muscle	0.96139330
60	MP0005647_abnormal_sex_gland	0.95961539
61	MP0000767_abnormal_smooth_muscle	0.94822012
62	MP0005085_abnormal_gallbladder_physiolo	0.93676733
63	MP0005389_reproductive_system_phenotype	0.91833163
64	MP0002282_abnormal_trachea_morphology	0.89843541
65	MP0004085_abnormal_heartbeat	0.89751657
66	MP0005058_abnormal_lysosome_morphology	0.89273897
67	MP0005646_abnormal_pituitary_gland	0.89258647
68	MP0000534_abnormal_ureter_morphology	0.89220139
69	MP0003935_abnormal_craniofacial_develop	0.88947981
70	MP0003698_abnormal_male_reproductive	0.84607399
71	MP0003045_fibrosis	0.83485781
72	MP0004510_myositis	0.80901799
73	MP0000762_abnormal_tongue_morphology	0.79526418
74	MP0003937_abnormal_limbs/digits/tail_de	0.77517692
75	MP0001879_abnormal_lymphatic_vessel	0.77206121
76	MP0001666_abnormal_nutrient_absorption	0.76271587
77	MP0001177_atelectasis	0.75431288
78	MP0000372_irregular_coat_pigmentation	0.75275128
79	MP0005253_abnormal_eye_physiology	0.73024536
80	MP0000049_abnormal_middle_ear	0.72985918
81	MP0003632_abnormal_nervous_system	0.69863665
82	MP0002133_abnormal_respiratory_system	0.69680118
83	MP0005388_respiratory_system_phenotype	0.69680118
84	MP0002269_muscular_atrophy	0.68982201
85	MP0010030_abnormal_orbit_morphology	0.68644959
86	MP0003755_abnormal_palate_morphology	0.66798917
87	MP0001544_abnormal_cardiovascular_syste	0.66556779
88	MP0005385_cardiovascular_system_phenoty	0.66556779
89	MP0004197_abnormal_fetal_growth/weight/	0.65176837
90	MP0002998_abnormal_bone_remodeling	0.64995672
91	MP0003936_abnormal_reproductive_system	0.62766766
92	MP0002128_abnormal_blood_circulation	0.60261188
93	MP0004087_abnormal_muscle_fiber	0.60186495
94	MP0002139_abnormal_hepatobiliary_system	0.59801830
95	MP0000751_myopathy	0.58956446
96	MP0002114_abnormal_axial_skeleton	0.58766937
97	MP0001929_abnormal_gametogenesis	0.58706866
98	MP0005391_vision/eye_phenotype	0.58617137
99	MP0002109_abnormal_limb_morphology	0.57483102
100	MP0001270_distended_abdomen	0.56174824

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aortic aneurysm (HP:0004942)	8.03145386
2	Aortic dissection (HP:0002647)	5.81690405
3	Abnormality of the columella (HP:0009929)	4.58346899
4	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	4.14169102
5	Vitreoretinal degeneration (HP:0000655)	4.12887468
6	Right ventricular cardiomyopathy (HP:0011663)	3.43324395
7	Reduced antithrombin III activity (HP:0001976)	3.38567690
8	Abnormality of the intrinsic pathway (HP:0010989)	3.38053665
9	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	3.36385910
10	Aortic regurgitation (HP:0001659)	3.17743591
11	Hypobetalipoproteinemia (HP:0003563)	3.14277269
12	Abnormality of the frontal sinuses (HP:0002687)	3.10343371
13	Thoracic kyphosis (HP:0002942)	3.00806560
14	Abnormality of the lumbar spine (HP:0100712)	3.00665105
15	Resting tremor (HP:0002322)	2.99285711
16	Thoracolumbar scoliosis (HP:0002944)	2.97575906
17	Complement deficiency (HP:0004431)	2.92810565
18	Retinal atrophy (HP:0001105)	2.84313052
19	Prolonged partial thromboplastin time (HP:0003645)	2.65684359
20	Abnormality of the calf musculature (HP:0001430)	2.63315326
21	Self-mutilation (HP:0000742)	2.57252899
22	Hyporeflexia of lower limbs (HP:0002600)	2.56503071
23	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.54794461
24	Aplasia involving bones of the upper limbs (HP:0009823)	2.53286255
25	Aplasia of the phalanges of the hand (HP:0009802)	2.53286255
26	Aplasia involving bones of the extremities (HP:0009825)	2.53286255
27	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.51312653
28	Malnutrition (HP:0004395)	2.49794648
29	Protruding tongue (HP:0010808)	2.49251844
30	High anterior hairline (HP:0009890)	2.48111157
31	Cerebellar dysplasia (HP:0007033)	2.46520057
32	Hypoplasia of the iris (HP:0007676)	2.36747040
33	Aneurysm (HP:0002617)	2.34557111
34	Abnormal sex determination (HP:0012244)	2.29609700
35	Sex reversal (HP:0012245)	2.29609700
36	Gonadal dysgenesis (HP:0000133)	2.29580779
37	Preaxial foot polydactyly (HP:0001841)	2.29414857
38	Hyperglycinemia (HP:0002154)	2.28840008
39	Clumsiness (HP:0002312)	2.24542879
40	Sensory axonal neuropathy (HP:0003390)	2.23378844
41	Deep venous thrombosis (HP:0002625)	2.23239517
42	Partial duplication of thumb phalanx (HP:0009944)	2.21312715
43	Facial hemangioma (HP:0000329)	2.21155059
44	Spinal rigidity (HP:0003306)	2.20133102
45	Abnormal ciliary motility (HP:0012262)	2.18898408
46	Capillary hemangiomas (HP:0005306)	2.15697845
47	Chronic hepatic failure (HP:0100626)	2.13695928
48	Spontaneous abortion (HP:0005268)	2.10578036
49	Ulnar bowing (HP:0003031)	2.08025377
50	Syncope (HP:0001279)	2.04459641
51	Abnormality of pyrimidine metabolism (HP:0004353)	2.03924921
52	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.03527349
53	Ventricular fibrillation (HP:0001663)	2.02832626
54	Abnormality of complement system (HP:0005339)	2.02763176
55	Blue irides (HP:0000635)	2.01925235
56	Neoplasm of the heart (HP:0100544)	2.01765321
57	Abnormality of the shoulder girdle musculature (HP:0001435)	2.01601522
58	Abnormality of the thoracic spine (HP:0100711)	2.00163790
59	Knee flexion contracture (HP:0006380)	1.99900215
60	Joint hemorrhage (HP:0005261)	1.98826588
61	Partial duplication of the phalanx of hand (HP:0009999)	1.98573776
62	Abnormality of incisor morphology (HP:0011063)	1.96512540
63	Abnormal respiratory motile cilium physiology (HP:0012261)	1.96304284
64	Calf muscle hypertrophy (HP:0008981)	1.95884534
65	Pigmentary retinal degeneration (HP:0001146)	1.94568578
66	Sudden death (HP:0001699)	1.94300829
67	High pitched voice (HP:0001620)	1.93986899
68	Colitis (HP:0002583)	1.93590253
69	Enlarged kidneys (HP:0000105)	1.92920124
70	Abnormality of the ischium (HP:0003174)	1.88863857
71	Hypolipoproteinemia (HP:0010981)	1.87618443
72	Abnormality of the incisor (HP:0000676)	1.87259590
73	Abnormal tarsal ossification (HP:0008369)	1.86986453
74	Infertility (HP:0000789)	1.86862743
75	Male pseudohermaphroditism (HP:0000037)	1.86194125
76	Retinal dysplasia (HP:0007973)	1.85551277
77	Median cleft lip (HP:0000161)	1.82965650
78	Coxa valga (HP:0002673)	1.82299884
79	Bifid scrotum (HP:0000048)	1.81697241
80	Germ cell neoplasia (HP:0100728)	1.80757461
81	Conjugated hyperbilirubinemia (HP:0002908)	1.80665789
82	Benign neoplasm of the central nervous system (HP:0100835)	1.78696641
83	Limited hip movement (HP:0008800)	1.77280299
84	Buphthalmos (HP:0000557)	1.77151409
85	Hypoventilation (HP:0002791)	1.76043984
86	Cerebral aneurysm (HP:0004944)	1.75340579
87	Hypoplasia of the uterus (HP:0000013)	1.75310412
88	Atrial fibrillation (HP:0005110)	1.75207531
89	White forelock (HP:0002211)	1.74222272
90	Alacrima (HP:0000522)	1.74200449
91	Muscular dystrophy (HP:0003560)	1.72824814
92	Abnormality of the common coagulation pathway (HP:0010990)	1.67935609
93	Intrahepatic cholestasis (HP:0001406)	1.67888844
94	Bicuspid aortic valve (HP:0001647)	1.67877735
95	Occipital encephalocele (HP:0002085)	1.67004319
96	Decreased lacrimation (HP:0000633)	1.66807301
97	Retinal detachment (HP:0000541)	1.66408166
98	Hip contracture (HP:0003273)	1.66347691
99	Abnormality of molar morphology (HP:0011070)	1.66253848
100	Abnormality of molar (HP:0011077)	1.66253848

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	6.71784744
2	MYLK	5.55163054
3	LATS1	4.68631457
4	MARK3	4.15063245
5	OBSCN	3.67156564
6	STK38L	3.37625449
7	NEK2	2.64969150
8	LATS2	2.40117546
9	PKN2	2.26305741
10	DMPK	2.01172465
11	MAPK15	1.87848968
12	CDC42BPA	1.78760222
13	PIK3CG	1.64193647
14	CDK3	1.64013738
15	PAK2	1.62508191
16	ZAK	1.62419748
17	TIE1	1.51819445
18	SGK223	1.47603263
19	SGK494	1.47603263
20	EEF2K	1.46566834
21	STK38	1.38580880
22	AKT3	1.38000490
23	BRSK2	1.37450878
24	CASK	1.37288654
25	FRK	1.35354855
26	PDGFRA	1.25606401
27	EIF2AK3	1.23343333
28	FGFR2	1.19602892
29	ACVR1B	1.16686545
30	BMPR1B	1.14931294
31	TLK1	1.12792769
32	FLT3	1.11040483
33	WEE1	1.08913081
34	MUSK	1.06695353
35	SGK2	1.04453288
36	NLK	0.98806983
37	PBK	0.97816539
38	RPS6KA5	0.94227744
39	MELK	0.92786238
40	STK3	0.92384555
41	MAP2K7	0.88173896
42	TGFBR1	0.87250792
43	TTN	0.84793587
44	CLK1	0.80303378
45	PIK3CA	0.80142650
46	MAP3K10	0.78911256
47	TNIK	0.77784673
48	CSNK1A1L	0.76524404
49	MTOR	0.75381589
50	MOS	0.73596909
51	RET	0.72454428
52	PLK4	0.70843214
53	ROCK1	0.67387548
54	RPS6KB1	0.66162881
55	PRKG2	0.65303460
56	MAPK12	0.63076981
57	DAPK3	0.63048430
58	CDK12	0.60549770
59	PAK1	0.60084119
60	DYRK3	0.58943841
61	SGK3	0.54235691
62	MAP3K1	0.51128701
63	PRKCQ	0.50417168
64	CSNK1G1	0.49367487
65	EGFR	0.45326743
66	PNCK	0.42379802
67	CSNK1G3	0.42371072
68	PDK2	0.40543610
69	ILK	0.40212461
70	VRK1	0.37997747
71	CAMK1	0.37091600
72	FGFR3	0.36909085
73	TRPM7	0.35866424
74	MAPKAPK3	0.33871014
75	NME2	0.31762171
76	AKT2	0.31270597
77	IRAK2	0.30593407
78	PTK2B	0.30491677
79	CAMK1G	0.29358619
80	RPS6KA1	0.28434831
81	GSK3A	0.28249456
82	RPS6KA2	0.26985676
83	PRKAA2	0.26144674
84	PDGFRB	0.25626301
85	CSNK1G2	0.24502373
86	TRIB3	0.23646608
87	ATM	0.23360324
88	TGFBR2	0.20534161
89	PRKG1	0.20215452
90	CAMK1D	0.20095214
91	FGFR1	0.19469711
92	WNK3	0.18885274
93	NEK9	0.18354636
94	CDK14	0.17944789
95	BTK	0.17309985
96	RPS6KA4	0.17037216
97	ICK	0.16559292
98	MAPK1	0.16423180
99	PRKACB	0.16222640
100	CDK5	0.15638587

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.22887896
2	Chemical carcinogenesis_Homo sapiens_hsa05204	2.83399919
3	Complement and coagulation cascades_Homo sapiens_hsa04610	2.69712311
4	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.51373363
5	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.50616776
6	Vascular smooth muscle contraction_Homo sapiens_hsa04270	2.42669855
7	Gap junction_Homo sapiens_hsa04540	2.32018164
8	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.30943416
9	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.26685678
10	Arginine biosynthesis_Homo sapiens_hsa00220	2.20815498
11	Retinol metabolism_Homo sapiens_hsa00830	2.17679889
12	Butanoate metabolism_Homo sapiens_hsa00650	2.08272137
13	Tyrosine metabolism_Homo sapiens_hsa00350	2.07995744
14	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.03032002
15	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.00624450
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.74335682
17	Propanoate metabolism_Homo sapiens_hsa00640	1.69476395
18	Phenylalanine metabolism_Homo sapiens_hsa00360	1.65976613
19	Olfactory transduction_Homo sapiens_hsa04740	1.63721814
20	Fatty acid degradation_Homo sapiens_hsa00071	1.62606615
21	Histidine metabolism_Homo sapiens_hsa00340	1.53414727
22	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.44773460
23	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.43588287
24	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.40462334
25	beta-Alanine metabolism_Homo sapiens_hsa00410	1.36462424
26	Circadian rhythm_Homo sapiens_hsa04710	1.34982437
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.34859090
28	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.34420026
29	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.34162724
30	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.33796262
31	ECM-receptor interaction_Homo sapiens_hsa04512	1.33240864
32	PPAR signaling pathway_Homo sapiens_hsa03320	1.33136445
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.31603662
34	Caffeine metabolism_Homo sapiens_hsa00232	1.26317608
35	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.23039155
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.21456769
37	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.19256540
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.19143561
39	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.18033478
40	Renin secretion_Homo sapiens_hsa04924	1.17571235
41	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.14203964
42	Mineral absorption_Homo sapiens_hsa04978	1.14134749
43	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.11210344
44	Pyruvate metabolism_Homo sapiens_hsa00620	1.11175510
45	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.04288474
46	Focal adhesion_Homo sapiens_hsa04510	1.03672151
47	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.97596305
48	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.96438086
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.96383786
50	Protein digestion and absorption_Homo sapiens_hsa04974	0.96199644
51	Prostate cancer_Homo sapiens_hsa05215	0.89312807
52	Glutathione metabolism_Homo sapiens_hsa00480	0.88876755
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.86805646
54	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.84835801
55	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.83851742
56	Tight junction_Homo sapiens_hsa04530	0.83086562
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.81933671
58	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.79845917
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.79237093
60	Bile secretion_Homo sapiens_hsa04976	0.76613937
61	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.72915670
62	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.68893527
63	Sphingolipid metabolism_Homo sapiens_hsa00600	0.68659530
64	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.68132589
65	Hippo signaling pathway_Homo sapiens_hsa04390	0.67782043
66	Apoptosis_Homo sapiens_hsa04210	0.66942746
67	Glucagon signaling pathway_Homo sapiens_hsa04922	0.65769481
68	ABC transporters_Homo sapiens_hsa02010	0.61389470
69	Melanogenesis_Homo sapiens_hsa04916	0.60519555
70	Wnt signaling pathway_Homo sapiens_hsa04310	0.59648076
71	Calcium signaling pathway_Homo sapiens_hsa04020	0.59571950
72	Taste transduction_Homo sapiens_hsa04742	0.55343090
73	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.55168489
74	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.54233512
75	Peroxisome_Homo sapiens_hsa04146	0.54148614
76	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.53542595
77	Salivary secretion_Homo sapiens_hsa04970	0.52804242
78	Lysine degradation_Homo sapiens_hsa00310	0.52390747
79	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.48210931
80	Basal cell carcinoma_Homo sapiens_hsa05217	0.46878565
81	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.46459371
82	Amoebiasis_Homo sapiens_hsa05146	0.45913962
83	Arginine and proline metabolism_Homo sapiens_hsa00330	0.44609836
84	Platelet activation_Homo sapiens_hsa04611	0.44325278
85	Adherens junction_Homo sapiens_hsa04520	0.44195103
86	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.42349350
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.42018754
88	Melanoma_Homo sapiens_hsa05218	0.41756782
89	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40566668
90	Alcoholism_Homo sapiens_hsa05034	0.40213159
91	Choline metabolism in cancer_Homo sapiens_hsa05231	0.38387094
92	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.38284600
93	Insulin resistance_Homo sapiens_hsa04931	0.38260298
94	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.38099052
95	Circadian entrainment_Homo sapiens_hsa04713	0.35811268
96	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.35521262
97	Phagosome_Homo sapiens_hsa04145	0.34614837
98	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.33470262
99	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.32583111
100	AMPK signaling pathway_Homo sapiens_hsa04152	0.31997050

LINC00890

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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