ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of memory T cell differentiation (GO:0043380)	6.60221199
2	negative regulation of multicellular organism growth (GO:0040015)	5.51612445
3	kynurenine metabolic process (GO:0070189)	4.81240842
4	indole-containing compound catabolic process (GO:0042436)	4.62616646
5	indolalkylamine catabolic process (GO:0046218)	4.62616646
6	tryptophan catabolic process (GO:0006569)	4.62616646
7	behavioral response to nicotine (GO:0035095)	4.46714049
8	regulation of establishment of cell polarity (GO:2000114)	4.29926564
9	L-fucose catabolic process (GO:0042355)	4.24194240
10	fucose catabolic process (GO:0019317)	4.24194240
11	L-fucose metabolic process (GO:0042354)	4.24194240
12	indolalkylamine metabolic process (GO:0006586)	4.22481024
13	regulation of MHC class I biosynthetic process (GO:0045343)	4.22303976
14	sex differentiation (GO:0007548)	4.11268903
15	detection of light stimulus involved in sensory perception (GO:0050962)	3.99598203
16	detection of light stimulus involved in visual perception (GO:0050908)	3.99598203
17	tryptophan metabolic process (GO:0006568)	3.97094008
18	cellular ketone body metabolic process (GO:0046950)	3.83359338
19	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.83021044
20	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.81823267
21	neural tube formation (GO:0001841)	3.81550492
22	piRNA metabolic process (GO:0034587)	3.81219241
23	cytoplasmic mRNA processing body assembly (GO:0033962)	3.71421158
24	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.54560091
25	ADP metabolic process (GO:0046031)	3.49694184
26	cerebellar Purkinje cell differentiation (GO:0021702)	3.48010052
27	protein polyglutamylation (GO:0018095)	3.45912690
28	ketone body metabolic process (GO:1902224)	3.43000893
29	regulation of action potential (GO:0098900)	3.39885956
30	dopamine transport (GO:0015872)	3.34864673
31	amino acid salvage (GO:0043102)	3.32773581
32	L-methionine salvage (GO:0071267)	3.32773581
33	L-methionine biosynthetic process (GO:0071265)	3.32773581
34	amine catabolic process (GO:0009310)	3.31505755
35	cellular biogenic amine catabolic process (GO:0042402)	3.31505755
36	seminiferous tubule development (GO:0072520)	3.31099612
37	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.29277309
38	indole-containing compound metabolic process (GO:0042430)	3.25888729
39	positive regulation of vasculogenesis (GO:2001214)	3.23986060
40	cholesterol catabolic process (GO:0006707)	3.22115461
41	sterol catabolic process (GO:0016127)	3.22115461
42	auditory receptor cell stereocilium organization (GO:0060088)	3.19505368
43	estrogen biosynthetic process (GO:0006703)	3.15716332
44	behavioral response to ethanol (GO:0048149)	3.15556381
45	synaptic transmission, cholinergic (GO:0007271)	3.12053660
46	photoreceptor cell maintenance (GO:0045494)	3.11032568
47	negative regulation of mast cell activation (GO:0033004)	3.10060395
48	neuronal action potential propagation (GO:0019227)	3.06422017
49	neuronal action potential (GO:0019228)	3.05342916
50	methionine biosynthetic process (GO:0009086)	3.02166231
51	DNA methylation involved in gamete generation (GO:0043046)	3.01931508
52	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.00815229
53	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.00815229
54	NADH dehydrogenase complex assembly (GO:0010257)	3.00815229
55	response to pheromone (GO:0019236)	3.00003137
56	male meiosis I (GO:0007141)	2.99396947
57	lipid particle organization (GO:0034389)	2.98631362
58	water-soluble vitamin biosynthetic process (GO:0042364)	2.98117822
59	preassembly of GPI anchor in ER membrane (GO:0016254)	2.97528228
60	somite rostral/caudal axis specification (GO:0032525)	2.95589896
61	retinal cone cell development (GO:0046549)	2.95280293
62	platelet dense granule organization (GO:0060155)	2.94890918
63	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.93633109
64	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.89825202
65	protein complex biogenesis (GO:0070271)	2.86052235
66	aromatic amino acid family catabolic process (GO:0009074)	2.84302569
67	multicellular organism reproduction (GO:0032504)	2.83697518
68	metallo-sulfur cluster assembly (GO:0031163)	2.82552545
69	iron-sulfur cluster assembly (GO:0016226)	2.82552545
70	proline transport (GO:0015824)	2.81274258
71	startle response (GO:0001964)	2.79040493
72	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.76885783
73	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.73259674
74	synapsis (GO:0007129)	2.72989231
75	benzene-containing compound metabolic process (GO:0042537)	2.72245641
76	gamma-aminobutyric acid transport (GO:0015812)	2.71677033
77	central nervous system neuron axonogenesis (GO:0021955)	2.71637200
78	mitochondrial respiratory chain complex assembly (GO:0033108)	2.71368387
79	reciprocal DNA recombination (GO:0035825)	2.69704640
80	reciprocal meiotic recombination (GO:0007131)	2.69704640
81	axoneme assembly (GO:0035082)	2.67852977
82	rRNA catabolic process (GO:0016075)	2.67190526
83	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.67047205
84	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.67047205
85	ubiquinone biosynthetic process (GO:0006744)	2.66940401
86	NAD biosynthetic process (GO:0009435)	2.65934910
87	male meiosis (GO:0007140)	2.65551339
88	alanine transport (GO:0032328)	2.63618226
89	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.63194608
90	protein-chromophore linkage (GO:0018298)	2.61550835
91	bile acid biosynthetic process (GO:0006699)	2.60184148
92	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.59108662
93	regulation of cilium movement (GO:0003352)	2.57024371
94	regulation of vasculogenesis (GO:2001212)	2.56886863
95	cilium morphogenesis (GO:0060271)	2.56716233
96	reflex (GO:0060004)	2.56427676
97	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.55889260
98	DNA deamination (GO:0045006)	2.54506648
99	mannosylation (GO:0097502)	2.53665593
100	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.52957987

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.69009037
2	VDR_22108803_ChIP-Seq_LS180_Human	3.60362078
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.24941664
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.03418983
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.96134365
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.89536980
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.63087018
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.59622606
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.58152118
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.55817806
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.55459283
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.48513064
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.32222988
14	ER_23166858_ChIP-Seq_MCF-7_Human	2.21773823
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11234960
16	FUS_26573619_Chip-Seq_HEK293_Human	2.03657112
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97479450
18	P300_19829295_ChIP-Seq_ESCs_Human	1.92983940
19	BCAT_22108803_ChIP-Seq_LS180_Human	1.89374579
20	EWS_26573619_Chip-Seq_HEK293_Human	1.85519962
21	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.85427072
22	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.82789538
23	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.76180260
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.73623523
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.72787945
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.61717936
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.61371490
28	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.59863097
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.58834350
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.58075018
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.58075018
32	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.57776525
33	STAT3_23295773_ChIP-Seq_U87_Human	1.57302738
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56741291
35	AR_25329375_ChIP-Seq_VCAP_Human	1.55446617
36	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.54816473
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.53441440
38	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.51268585
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49595618
40	TCF4_23295773_ChIP-Seq_U87_Human	1.46896508
41	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.45807392
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.45140860
43	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.45140860
44	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.40702669
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37330232
46	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.36005405
47	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.35630751
48	TCF4_22108803_ChIP-Seq_LS180_Human	1.33379690
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.33285017
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.32272956
51	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.32020143
52	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31424079
53	IRF1_19129219_ChIP-ChIP_H3396_Human	1.31103655
54	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.31081482
55	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.30594656
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.29935712
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.27596066
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.27596066
59	CDX2_22108803_ChIP-Seq_LS180_Human	1.26113450
60	MYC_18940864_ChIP-ChIP_HL60_Human	1.25812558
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24735599
62	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.22980915
63	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.20991745
64	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.20686786
65	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.19181605
66	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.18903738
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17283168
68	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.16474470
69	REST_21632747_ChIP-Seq_MESCs_Mouse	1.14682288
70	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13592424
71	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.13592424
72	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.13430553
73	NCOR_22424771_ChIP-Seq_293T_Human	1.13311705
74	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.11636708
75	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11578137
76	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.11142683
77	AR_20517297_ChIP-Seq_VCAP_Human	1.10502284
78	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10386645
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09642363
80	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.09428903
81	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.08097494
82	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07576720
83	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05438586
84	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.05136999
85	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.05101747
86	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.03901281
87	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02957625
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02572288
89	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.01200583
90	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00511523
91	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.99427587
92	KDM2B_26808549_Chip-Seq_REH_Human	0.98843162
93	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.98319775
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98274726
95	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.97294141
96	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.97125669
97	P53_22387025_ChIP-Seq_ESCs_Mouse	0.96281663
98	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95407867
99	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.94584391
100	TBL1_22424771_ChIP-Seq_293T_Human	0.94516744

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003011_delayed_dark_adaptation	3.55357308
2	MP0001968_abnormal_touch/_nociception	3.40559703
3	MP0002102_abnormal_ear_morphology	3.34620130
4	MP0002736_abnormal_nociception_after	3.28159421
5	MP0003195_calcinosis	3.17530579
6	MP0005551_abnormal_eye_electrophysiolog	2.99770900
7	MP0005646_abnormal_pituitary_gland	2.79202036
8	MP0008877_abnormal_DNA_methylation	2.76638098
9	MP0003252_abnormal_bile_duct	2.66573983
10	MP0001986_abnormal_taste_sensitivity	2.32694363
11	MP0005253_abnormal_eye_physiology	2.26958123
12	MP0009046_muscle_twitch	2.19440440
13	MP0004147_increased_porphyrin_level	2.11026219
14	MP0000372_irregular_coat_pigmentation	2.08819175
15	MP0006072_abnormal_retinal_apoptosis	2.07214943
16	MP0000569_abnormal_digit_pigmentation	2.00650050
17	MP0006276_abnormal_autonomic_nervous	1.98456293
18	MP0009745_abnormal_behavioral_response	1.96996417
19	MP0001501_abnormal_sleep_pattern	1.95696761
20	MP0002876_abnormal_thyroid_physiology	1.94842852
21	MP0008875_abnormal_xenobiotic_pharmacok	1.79645370
22	MP0000427_abnormal_hair_cycle	1.75617591
23	MP0002837_dystrophic_cardiac_calcinosis	1.74818509
24	MP0005645_abnormal_hypothalamus_physiol	1.73106332
25	MP0003646_muscle_fatigue	1.62745540
26	MP0003718_maternal_effect	1.62075869
27	MP0002272_abnormal_nervous_system	1.60637791
28	MP0001486_abnormal_startle_reflex	1.57313913
29	MP0004142_abnormal_muscle_tone	1.56832126
30	MP0004043_abnormal_pH_regulation	1.54029635
31	MP0004885_abnormal_endolymph	1.49187759
32	MP0003950_abnormal_plasma_membrane	1.48207744
33	MP0002163_abnormal_gland_morphology	1.48152854
34	MP0005379_endocrine/exocrine_gland_phen	1.45897784
35	MP0005410_abnormal_fertilization	1.43275601
36	MP0003787_abnormal_imprinting	1.39917003
37	MP0002733_abnormal_thermal_nociception	1.39853109
38	MP0008872_abnormal_physiological_respon	1.39815749
39	MP0006035_abnormal_mitochondrial_morpho	1.37068158
40	MP0003880_abnormal_central_pattern	1.36020203
41	MP0004924_abnormal_behavior	1.35771484
42	MP0005386_behavior/neurological_phenoty	1.35771484
43	MP0001529_abnormal_vocalization	1.34362359
44	MP0005647_abnormal_sex_gland	1.33146536
45	MP0002638_abnormal_pupillary_reflex	1.29730168
46	MP0008775_abnormal_heart_ventricle	1.23395861
47	MP0002064_seizures	1.19022156
48	MP0005187_abnormal_penis_morphology	1.15570212
49	MP0000631_abnormal_neuroendocrine_gland	1.15421800
50	MP0001970_abnormal_pain_threshold	1.12533524
51	MP0004133_heterotaxia	1.12524454
52	MP0002572_abnormal_emotion/affect_behav	1.12337718
53	MP0010386_abnormal_urinary_bladder	1.11772537
54	MP0002067_abnormal_sensory_capabilities	1.09816247
55	MP0004742_abnormal_vestibular_system	1.09628680
56	MP0002254_reproductive_system_inflammat	1.09531462
57	MP0003186_abnormal_redox_activity	1.03776084
58	MP0006292_abnormal_olfactory_placode	1.02418976
59	MP0002557_abnormal_social/conspecific_i	1.02233317
60	MP0005389_reproductive_system_phenotype	1.02156785
61	MP0005084_abnormal_gallbladder_morpholo	1.01572087
62	MP0001905_abnormal_dopamine_level	0.99267296
63	MP0005075_abnormal_melanosome_morpholog	0.98419894
64	MP0000230_abnormal_systemic_arterial	0.98061742
65	MP0002160_abnormal_reproductive_system	0.98000589
66	MP0002693_abnormal_pancreas_physiology	0.93281493
67	MP0003698_abnormal_male_reproductive	0.91889127
68	MP0000653_abnormal_sex_gland	0.91807378
69	MP0002282_abnormal_trachea_morphology	0.91640259
70	MP0006036_abnormal_mitochondrial_physio	0.91089427
71	MP0008058_abnormal_DNA_repair	0.90929926
72	MP0002938_white_spotting	0.90016372
73	MP0002735_abnormal_chemical_nociception	0.89530635
74	MP0009780_abnormal_chondrocyte_physiolo	0.88938442
75	MP0001485_abnormal_pinna_reflex	0.88325285
76	MP0000647_abnormal_sebaceous_gland	0.88050969
77	MP0001764_abnormal_homeostasis	0.86673638
78	MP0005195_abnormal_posterior_eye	0.86131427
79	MP0002751_abnormal_autonomic_nervous	0.85138745
80	MP0002229_neurodegeneration	0.85133289
81	MP0003136_yellow_coat_color	0.84487378
82	MP0005310_abnormal_salivary_gland	0.84411895
83	MP0008995_early_reproductive_senescence	0.84165624
84	MP0004215_abnormal_myocardial_fiber	0.83812753
85	MP0000383_abnormal_hair_follicle	0.80483339
86	MP0003635_abnormal_synaptic_transmissio	0.79859483
87	MP0003137_abnormal_impulse_conducting	0.79051457
88	MP0001929_abnormal_gametogenesis	0.78742904
89	MP0005636_abnormal_mineral_homeostasis	0.77105591
90	MP0002909_abnormal_adrenal_gland	0.76050765
91	MP0002752_abnormal_somatic_nervous	0.75955738
92	MP0002210_abnormal_sex_determination	0.75154846
93	MP0001984_abnormal_olfaction	0.74711922
94	MP0000371_diluted_coat_color	0.74624485
95	MP0003786_premature_aging	0.73484792
96	MP0001145_abnormal_male_reproductive	0.73065947
97	MP0005332_abnormal_amino_acid	0.71885521
98	MP0001119_abnormal_female_reproductive	0.71318976
99	MP0005395_other_phenotype	0.71201836
100	MP0006054_spinal_hemorrhage	0.70063211

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	5.41545878
2	Progressive cerebellar ataxia (HP:0002073)	4.51665504
3	Gaze-evoked nystagmus (HP:0000640)	4.34241585
4	Pancreatic cysts (HP:0001737)	4.16076201
5	Congenital stationary night blindness (HP:0007642)	4.11536636
6	Pancreatic fibrosis (HP:0100732)	4.01022743
7	True hermaphroditism (HP:0010459)	3.88958879
8	Pendular nystagmus (HP:0012043)	3.81787094
9	Action tremor (HP:0002345)	3.80446572
10	Prostate neoplasm (HP:0100787)	3.62633725
11	Hyperventilation (HP:0002883)	3.54815765
12	Attenuation of retinal blood vessels (HP:0007843)	3.46408047
13	Abnormality of the renal cortex (HP:0011035)	3.34853924
14	Nephronophthisis (HP:0000090)	3.32602807
15	Keratoconus (HP:0000563)	3.24711677
16	Increased corneal curvature (HP:0100692)	3.24711677
17	Molar tooth sign on MRI (HP:0002419)	3.22501507
18	Abnormality of midbrain morphology (HP:0002418)	3.22501507
19	Dysmetric saccades (HP:0000641)	3.10249721
20	Inability to walk (HP:0002540)	3.06878839
21	Renal cortical cysts (HP:0000803)	3.02347346
22	Type II lissencephaly (HP:0007260)	3.01394743
23	Medial flaring of the eyebrow (HP:0010747)	2.96241460
24	Abolished electroretinogram (ERG) (HP:0000550)	2.89320534
25	Tubular atrophy (HP:0000092)	2.88325872
26	Abnormality of the renal medulla (HP:0100957)	2.82529826
27	Abnormality of macular pigmentation (HP:0008002)	2.82145568
28	Progressive inability to walk (HP:0002505)	2.74078611
29	Focal seizures (HP:0007359)	2.73157263
30	Decreased central vision (HP:0007663)	2.72304616
31	Absence seizures (HP:0002121)	2.70628350
32	Dialeptic seizures (HP:0011146)	2.67674396
33	Chronic hepatic failure (HP:0100626)	2.60403990
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.60255534
35	Abnormality of alanine metabolism (HP:0010916)	2.60255534
36	Hyperalaninemia (HP:0003348)	2.60255534
37	Abnormality of the hepatic vasculature (HP:0006707)	2.57456149
38	Abnormal rod and cone electroretinograms (HP:0008323)	2.55310236
39	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.43232154
40	Hypoplasia of the fovea (HP:0007750)	2.43232154
41	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.42705030
42	Dysdiadochokinesis (HP:0002075)	2.42554302
43	Cystic liver disease (HP:0006706)	2.40599246
44	Congenital sensorineural hearing impairment (HP:0008527)	2.39049580
45	Hemiparesis (HP:0001269)	2.38076149
46	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.37270371
47	Severe visual impairment (HP:0001141)	2.30633888
48	Febrile seizures (HP:0002373)	2.30501350
49	Sclerocornea (HP:0000647)	2.30388950
50	Abnormality of the prostate (HP:0008775)	2.30151685
51	Cerebellar dysplasia (HP:0007033)	2.29824947
52	Abnormal drinking behavior (HP:0030082)	2.27991551
53	Polydipsia (HP:0001959)	2.27991551
54	Absent speech (HP:0001344)	2.23480610
55	Gait imbalance (HP:0002141)	2.22384662
56	Bony spicule pigmentary retinopathy (HP:0007737)	2.22108023
57	Congenital primary aphakia (HP:0007707)	2.19893780
58	Retinitis pigmentosa (HP:0000510)	2.19165548
59	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.17277843
60	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.14966686
61	Congenital hepatic fibrosis (HP:0002612)	2.14160374
62	Broad-based gait (HP:0002136)	2.14117024
63	Protruding tongue (HP:0010808)	2.12844102
64	Urinary bladder sphincter dysfunction (HP:0002839)	2.12325029
65	Chorioretinal atrophy (HP:0000533)	2.11369391
66	Abnormality of the fovea (HP:0000493)	2.09271395
67	Nephrogenic diabetes insipidus (HP:0009806)	2.06475125
68	Hypochromic microcytic anemia (HP:0004840)	2.01391845
69	Increased CSF lactate (HP:0002490)	1.99944916
70	Optic nerve hypoplasia (HP:0000609)	1.99267251
71	3-Methylglutaconic aciduria (HP:0003535)	1.97103741
72	Generalized aminoaciduria (HP:0002909)	1.96131348
73	Focal motor seizures (HP:0011153)	1.93461303
74	Disproportionate short-trunk short stature (HP:0003521)	1.93296021
75	Hyperglycinuria (HP:0003108)	1.92918141
76	Furrowed tongue (HP:0000221)	1.91636622
77	Bile duct proliferation (HP:0001408)	1.91472093
78	Abnormal biliary tract physiology (HP:0012439)	1.91472093
79	Male pseudohermaphroditism (HP:0000037)	1.88043922
80	Concave nail (HP:0001598)	1.87532996
81	Hypothermia (HP:0002045)	1.86977680
82	Tubulointerstitial nephritis (HP:0001970)	1.86922811
83	Clumsiness (HP:0002312)	1.85784544
84	Anencephaly (HP:0002323)	1.85137514
85	Postural instability (HP:0002172)	1.83328569
86	Lissencephaly (HP:0001339)	1.83190538
87	Mitochondrial inheritance (HP:0001427)	1.81363212
88	Hepatic necrosis (HP:0002605)	1.80394758
89	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.79758506
90	Postaxial foot polydactyly (HP:0001830)	1.78141887
91	Stomach cancer (HP:0012126)	1.77971071
92	Postural tremor (HP:0002174)	1.76647987
93	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.74738558
94	Oculomotor apraxia (HP:0000657)	1.74425450
95	Ketoacidosis (HP:0001993)	1.74157724
96	Abnormality of proline metabolism (HP:0010907)	1.74130577
97	Hydroxyprolinuria (HP:0003080)	1.74130577
98	Atonic seizures (HP:0010819)	1.74076108
99	Pachygyria (HP:0001302)	1.71819547
100	Genital tract atresia (HP:0001827)	1.70756464

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.66129168
2	CDK19	4.05313215
3	ADRBK2	3.52703560
4	OXSR1	3.26271776
5	MAP4K2	3.16586882
6	ZAK	3.03934002
7	BMPR1B	2.80580711
8	GRK1	2.54402539
9	NUAK1	2.53116686
10	PINK1	2.29722945
11	ACVR1B	2.24083734
12	WNK4	1.93990931
13	WNK3	1.90703039
14	CASK	1.86066619
15	TAOK3	1.55457629
16	INSRR	1.55119630
17	BCR	1.50704246
18	MKNK1	1.41722888
19	TXK	1.39475877
20	MKNK2	1.27443905
21	BCKDK	1.26087312
22	MAPK13	1.25544360
23	TRIM28	1.21389733
24	ADRBK1	1.20321407
25	STK38L	1.17919298
26	TIE1	1.15773542
27	MAP3K4	1.14537093
28	CSNK1G2	1.14204779
29	MST4	1.10225330
30	STK3	1.10147087
31	MAPKAPK5	1.09820623
32	CSNK1G3	1.08634465
33	CSNK1G1	1.06929418
34	MAP3K7	1.05082628
35	TGFBR1	1.03494117
36	STK39	0.97958603
37	PAK3	0.97479430
38	TNK2	0.96103178
39	MAP2K7	0.94421566
40	PLK2	0.93112843
41	DYRK2	0.91384752
42	MARK1	0.89670418
43	TLK1	0.89043999
44	TAF1	0.88137073
45	PTK2B	0.86323293
46	TEC	0.83841389
47	PRKCG	0.83338269
48	CSNK1A1L	0.82958173
49	FER	0.80781799
50	PRKCE	0.80733818
51	EPHA3	0.80288706
52	DAPK2	0.79314482
53	PLK4	0.77655953
54	AKT3	0.69658103
55	MUSK	0.68992454
56	KIT	0.66047306
57	GRK5	0.65383005
58	TNIK	0.64748866
59	MAP2K6	0.58351465
60	GRK7	0.57324301
61	PLK3	0.56079944
62	STK11	0.55802030
63	VRK1	0.55345352
64	VRK2	0.55084073
65	CSNK1A1	0.50252465
66	NTRK3	0.49700072
67	PRKCQ	0.47244572
68	PRKAA2	0.46762249
69	RPS6KA5	0.45798445
70	MATK	0.45496166
71	CAMK2A	0.43967561
72	IKBKB	0.41920548
73	DYRK1A	0.40036994
74	PIK3CG	0.35899393
75	FGFR2	0.34986618
76	PRKACA	0.34691117
77	PNCK	0.33826688
78	DYRK3	0.33127590
79	PKN1	0.32418063
80	STK38	0.31118843
81	PRKG1	0.30785520
82	CDK8	0.30443819
83	ITK	0.30414914
84	IRAK1	0.30408183
85	PRKCA	0.29518671
86	PHKG1	0.29375199
87	PHKG2	0.29375199
88	ERBB3	0.28589901
89	NLK	0.28539851
90	CHEK2	0.28478106
91	IGF1R	0.27787945
92	PIK3CA	0.26968319
93	MAPKAPK3	0.26832917
94	CSNK1D	0.26788797
95	PLK1	0.25207016
96	ABL1	0.25203944
97	PRKAA1	0.23920408
98	CAMK1	0.22488415
99	OBSCN	0.20882333
100	PRKG2	0.20786885

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.39841294
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.53226846
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.51620723
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.45361730
5	Phototransduction_Homo sapiens_hsa04744	2.44038538
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.42413093
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.42332145
8	Butanoate metabolism_Homo sapiens_hsa00650	2.37980018
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.23239264
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.20851427
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.12998064
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.08829069
13	Ether lipid metabolism_Homo sapiens_hsa00565	2.07465787
14	Tryptophan metabolism_Homo sapiens_hsa00380	2.07098281
15	Caffeine metabolism_Homo sapiens_hsa00232	1.93113609
16	RNA polymerase_Homo sapiens_hsa03020	1.89409269
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.83523714
18	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.82662727
19	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.70634318
20	Olfactory transduction_Homo sapiens_hsa04740	1.69655282
21	Basal transcription factors_Homo sapiens_hsa03022	1.68058845
22	Nicotine addiction_Homo sapiens_hsa05033	1.67478043
23	Taste transduction_Homo sapiens_hsa04742	1.63435214
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.56640114
25	Propanoate metabolism_Homo sapiens_hsa00640	1.53726774
26	Retinol metabolism_Homo sapiens_hsa00830	1.50563592
27	Homologous recombination_Homo sapiens_hsa03440	1.47606949
28	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.46513498
29	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.46319724
30	Oxidative phosphorylation_Homo sapiens_hsa00190	1.31742558
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.30747973
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.26339203
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.24547343
34	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.15971523
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.14899603
36	Protein export_Homo sapiens_hsa03060	1.13682665
37	ABC transporters_Homo sapiens_hsa02010	1.10365361
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.08327929
39	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.06352034
40	One carbon pool by folate_Homo sapiens_hsa00670	1.05125637
41	Morphine addiction_Homo sapiens_hsa05032	1.04898788
42	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.04060852
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.01094596
44	Parkinsons disease_Homo sapiens_hsa05012	0.98642338
45	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.98317380
46	Non-homologous end-joining_Homo sapiens_hsa03450	0.97005674
47	Circadian rhythm_Homo sapiens_hsa04710	0.95054138
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.95022512
49	Peroxisome_Homo sapiens_hsa04146	0.94435960
50	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.92988500
51	Salivary secretion_Homo sapiens_hsa04970	0.90493550
52	Glutamatergic synapse_Homo sapiens_hsa04724	0.90099367
53	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.85322648
54	Purine metabolism_Homo sapiens_hsa00230	0.84790378
55	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.84553521
56	GABAergic synapse_Homo sapiens_hsa04727	0.84503824
57	RNA degradation_Homo sapiens_hsa03018	0.84128919
58	Sulfur metabolism_Homo sapiens_hsa00920	0.83321333
59	Glycerolipid metabolism_Homo sapiens_hsa00561	0.82437481
60	Insulin secretion_Homo sapiens_hsa04911	0.80553806
61	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.77515478
62	Serotonergic synapse_Homo sapiens_hsa04726	0.76869837
63	Circadian entrainment_Homo sapiens_hsa04713	0.75078141
64	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.74506319
65	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.72339171
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.72271328
67	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.69786438
68	Long-term depression_Homo sapiens_hsa04730	0.69242682
69	Regulation of autophagy_Homo sapiens_hsa04140	0.69061992
70	Metabolic pathways_Homo sapiens_hsa01100	0.67185466
71	Calcium signaling pathway_Homo sapiens_hsa04020	0.65437106
72	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.64580724
73	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.62361853
74	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.62202478
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.61268506
76	Huntingtons disease_Homo sapiens_hsa05016	0.60474969
77	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.59303255
78	Pyrimidine metabolism_Homo sapiens_hsa00240	0.56743419
79	Alzheimers disease_Homo sapiens_hsa05010	0.56470380
80	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.51868970
81	Collecting duct acid secretion_Homo sapiens_hsa04966	0.50742336
82	Sulfur relay system_Homo sapiens_hsa04122	0.50633438
83	Fatty acid degradation_Homo sapiens_hsa00071	0.50352558
84	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.48552608
85	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.46197569
86	Fatty acid elongation_Homo sapiens_hsa00062	0.45124978
87	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.44703034
88	Sphingolipid metabolism_Homo sapiens_hsa00600	0.42426320
89	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.40646418
90	Cardiac muscle contraction_Homo sapiens_hsa04260	0.40507273
91	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.40023486
92	Proteasome_Homo sapiens_hsa03050	0.36927387
93	Mineral absorption_Homo sapiens_hsa04978	0.35415209
94	Asthma_Homo sapiens_hsa05310	0.33999883
95	Type I diabetes mellitus_Homo sapiens_hsa04940	0.33060684
96	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.31487174
97	Steroid biosynthesis_Homo sapiens_hsa00100	0.31402033
98	Gastric acid secretion_Homo sapiens_hsa04971	0.31120178
99	Fatty acid metabolism_Homo sapiens_hsa01212	0.30424136
100	Primary immunodeficiency_Homo sapiens_hsa05340	0.30110152

LINC00933

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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