ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cysteine metabolic process (GO:0006534)	5.95684535
2	regulation of interleukin-12 biosynthetic process (GO:0045075)	5.49101646
3	protein K11-linked deubiquitination (GO:0035871)	4.76982064
4	response to nitrosative stress (GO:0051409)	4.74143332
5	response to xenobiotic stimulus (GO:0009410)	4.55270610
6	interleukin-6-mediated signaling pathway (GO:0070102)	4.24229733
7	regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043	4.21788833
8	protein heterotetramerization (GO:0051290)	4.08826161
9	negative regulation of T cell differentiation in thymus (GO:0033085)	4.08502383
10	adaptation of signaling pathway (GO:0023058)	3.88823838
11	respiratory chain complex IV assembly (GO:0008535)	3.79935048
12	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.70663896
13	N-terminal protein amino acid acetylation (GO:0006474)	3.67016245
14	proteasome assembly (GO:0043248)	3.66027141
15	cytidine metabolic process (GO:0046087)	3.64849512
16	cytidine catabolic process (GO:0006216)	3.64849512
17	cytidine deamination (GO:0009972)	3.64849512
18	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	3.64135183
19	DNA deamination (GO:0045006)	3.59388426
20	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.57770254
21	negative regulation of muscle hypertrophy (GO:0014741)	3.51732278
22	regulation of energy homeostasis (GO:2000505)	3.41087555
23	pseudouridine synthesis (GO:0001522)	3.40005818
24	fucose catabolic process (GO:0019317)	3.37465040
25	L-fucose metabolic process (GO:0042354)	3.37465040
26	L-fucose catabolic process (GO:0042355)	3.37465040
27	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.31611610
28	negative regulation of cardiac muscle hypertrophy (GO:0010614)	3.28495922
29	maturation of 5.8S rRNA (GO:0000460)	3.19942356
30	positive regulation of T cell apoptotic process (GO:0070234)	3.19470398
31	cellular response to interleukin-6 (GO:0071354)	3.18395897
32	cytochrome complex assembly (GO:0017004)	3.16640801
33	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.15890263
34	multicellular organism reproduction (GO:0032504)	3.15573743
35	response to pheromone (GO:0019236)	3.13110462
36	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.11536915
37	glutathione derivative metabolic process (GO:1901685)	3.09978282
38	glutathione derivative biosynthetic process (GO:1901687)	3.09978282
39	regulation of cellular respiration (GO:0043457)	3.05878542
40	auditory receptor cell stereocilium organization (GO:0060088)	2.99099110
41	glutathione biosynthetic process (GO:0006750)	2.97397912
42	forebrain morphogenesis (GO:0048853)	2.96164318
43	protein-cofactor linkage (GO:0018065)	2.95029603
44	tyrosine metabolic process (GO:0006570)	2.91980966
45	negative regulation of glycogen biosynthetic process (GO:0045719)	2.87608098
46	piRNA metabolic process (GO:0034587)	2.87366845
47	positive regulation of natural killer cell differentiation (GO:0032825)	2.86823072
48	galactose metabolic process (GO:0006012)	2.80555095
49	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.78243997
50	regulation of oxidative stress-induced neuron death (GO:1903203)	2.76602685
51	DNA double-strand break processing (GO:0000729)	2.75884547
52	protein polyglutamylation (GO:0018095)	2.75767557
53	platelet dense granule organization (GO:0060155)	2.74370753
54	tolerance induction (GO:0002507)	2.73522365
55	nonribosomal peptide biosynthetic process (GO:0019184)	2.73001117
56	regulation of thymocyte apoptotic process (GO:0070243)	2.72469748
57	response to interleukin-6 (GO:0070741)	2.71025005
58	interferon-gamma production (GO:0032609)	2.70658872
59	galactose catabolic process (GO:0019388)	2.68351547
60	heart process (GO:0003015)	2.67573246
61	heart contraction (GO:0060047)	2.67573246
62	positive regulation of glycolytic process (GO:0045821)	2.67012535
63	termination of RNA polymerase III transcription (GO:0006386)	2.65853727
64	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.65853727
65	cellular response to zinc ion (GO:0071294)	2.65144353
66	melanin biosynthetic process (GO:0042438)	2.64719507
67	vesicle fusion (GO:0006906)	2.64412199
68	lactate metabolic process (GO:0006089)	2.59723917
69	negative regulation of mast cell activation (GO:0033004)	2.59268991
70	dopamine transport (GO:0015872)	2.55913879
71	sulfation (GO:0051923)	2.55103830
72	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.54881689
73	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.54768810
74	ubiquinone biosynthetic process (GO:0006744)	2.54502984
75	activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)	2.53777812
76	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.52674171
77	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.52674171
78	regulation of hippo signaling (GO:0035330)	2.51399290
79	glycolipid biosynthetic process (GO:0009247)	2.49980497
80	rRNA methylation (GO:0031167)	2.49872978
81	behavioral response to nicotine (GO:0035095)	2.49785633
82	intestinal epithelial cell development (GO:0060576)	2.48093896
83	secondary metabolite biosynthetic process (GO:0044550)	2.46378347
84	rRNA modification (GO:0000154)	2.45546039
85	membrane tubulation (GO:0097320)	2.45197708
86	regulation of cellular amino acid metabolic process (GO:0006521)	2.43446984
87	ribosome biogenesis (GO:0042254)	2.43274621
88	negative regulation of JAK-STAT cascade (GO:0046426)	2.43045445
89	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.42774571
90	S-adenosylmethionine metabolic process (GO:0046500)	2.42166106
91	negative regulation of execution phase of apoptosis (GO:1900118)	2.42049047
92	negative regulation of glycogen metabolic process (GO:0070874)	2.41947279
93	L-phenylalanine catabolic process (GO:0006559)	2.41614868
94	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.41614868
95	signal peptide processing (GO:0006465)	2.41171322
96	recombinational repair (GO:0000725)	2.39607387
97	double-strand break repair via homologous recombination (GO:0000724)	2.39526094
98	acrosome reaction (GO:0007340)	2.38944066
99	regulation of acrosome reaction (GO:0060046)	2.37554235
100	protein complex biogenesis (GO:0070271)	2.36036339

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.65293201
2	VDR_22108803_ChIP-Seq_LS180_Human	3.46098484
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.16043427
4	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.84562517
5	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.69451703
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.60409265
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.49810995
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.40415708
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.37647660
10	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.25189552
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.04285409
12	ER_23166858_ChIP-Seq_MCF-7_Human	1.99271062
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.98285420
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.98106478
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.94150462
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.92728973
17	IGF1R_20145208_ChIP-Seq_DFB_Human	1.91833759
18	P300_19829295_ChIP-Seq_ESCs_Human	1.90367235
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.89175698
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.84089691
21	CBP_20019798_ChIP-Seq_JUKART_Human	1.80307372
22	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.80307372
23	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.76637023
24	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.72450380
25	ELK1_19687146_ChIP-ChIP_HELA_Human	1.71183212
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.71125910
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.64829383
28	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.63460688
29	BCAT_22108803_ChIP-Seq_LS180_Human	1.63169485
30	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.63026981
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.60622801
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.58587344
33	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.58556707
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.58443979
35	FUS_26573619_Chip-Seq_HEK293_Human	1.58312489
36	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.56704767
37	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.55481672
38	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.54780112
39	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.54565084
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.54393313
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.52747231
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48815500
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.47251460
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.46139737
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.42550626
46	STAT3_23295773_ChIP-Seq_U87_Human	1.42470411
47	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.41449906
48	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.39065404
49	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.37347244
50	SMAD4_21799915_ChIP-Seq_A2780_Human	1.37209131
51	HOXB7_26014856_ChIP-Seq_BT474_Human	1.36568412
52	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.36554987
53	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.34598654
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.34598654
55	VDR_23849224_ChIP-Seq_CD4+_Human	1.33361502
56	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.32510819
57	EWS_26573619_Chip-Seq_HEK293_Human	1.31291472
58	TCF4_22108803_ChIP-Seq_LS180_Human	1.28345827
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28032887
60	TCF4_23295773_ChIP-Seq_U87_Human	1.26259925
61	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.25315826
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23480305
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23480305
64	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.22949578
65	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.21650537
66	CDX2_22108803_ChIP-Seq_LS180_Human	1.21311154
67	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.20791126
68	NCOR_22424771_ChIP-Seq_293T_Human	1.20552093
69	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.17965355
70	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.17298498
71	AR_25329375_ChIP-Seq_VCAP_Human	1.14960050
72	PHF8_20622853_ChIP-Seq_HELA_Human	1.14066931
73	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13434415
74	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.11680756
75	TP53_16413492_ChIP-PET_HCT116_Human	1.11367772
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.11329478
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.09445223
78	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09421023
79	GATA3_26560356_Chip-Seq_TH2_Human	1.08753324
80	RBPJ_21746931_ChIP-Seq_IB4_Human	1.08177754
81	AR_20517297_ChIP-Seq_VCAP_Human	1.07274806
82	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.06929679
83	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.06686284
84	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.06552702
85	CJUN_26792858_Chip-Seq_BT549_Human	1.06424272
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05867124
87	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05851481
88	HTT_18923047_ChIP-ChIP_STHdh_Human	1.04889899
89	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04830467
90	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.04293733
91	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.04246198
92	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.03548963
93	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03376398
94	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.03286201
95	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.01554239
96	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.00642054
97	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.00387517
98	NANOG_20526341_ChIP-Seq_ESCs_Human	1.00144539
99	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.99408790
100	NFYB_21822215_ChIP-Seq_K562_Human	0.99164983

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006054_spinal_hemorrhage	5.54960225
2	MP0002837_dystrophic_cardiac_calcinosis	5.10516238
3	MP0000372_irregular_coat_pigmentation	4.19207600
4	MP0003950_abnormal_plasma_membrane	3.90236840
5	MP0001986_abnormal_taste_sensitivity	3.14757719
6	MP0002653_abnormal_ependyma_morphology	3.10127235
7	MP0003195_calcinosis	3.01370089
8	MP0004084_abnormal_cardiac_muscle	2.56118502
9	MP0008875_abnormal_xenobiotic_pharmacok	2.42728175
10	MP0005171_absent_coat_pigmentation	2.25540288
11	MP0002102_abnormal_ear_morphology	2.24597373
12	MP0003646_muscle_fatigue	2.23377668
13	MP0003136_yellow_coat_color	2.17988458
14	MP0005075_abnormal_melanosome_morpholog	2.17373352
15	MP0005174_abnormal_tail_pigmentation	2.14804895
16	MP0000569_abnormal_digit_pigmentation	2.07445104
17	MP0004147_increased_porphyrin_level	1.95173293
18	MP0004381_abnormal_hair_follicle	1.93499013
19	MP0002095_abnormal_skin_pigmentation	1.90863059
20	MP0005408_hypopigmentation	1.87959867
21	MP0003186_abnormal_redox_activity	1.84329284
22	MP0005551_abnormal_eye_electrophysiolog	1.82778620
23	MP0009785_altered_susceptibility_to	1.78934973
24	MP0005310_abnormal_salivary_gland	1.76743578
25	MP0001764_abnormal_homeostasis	1.75493027
26	MP0004145_abnormal_muscle_electrophysio	1.75282157
27	MP0002938_white_spotting	1.61225093
28	MP0004484_altered_response_of	1.56432138
29	MP0003890_abnormal_embryonic-extraembry	1.56227827
30	MP0000015_abnormal_ear_pigmentation	1.52632754
31	MP0004215_abnormal_myocardial_fiber	1.51614820
32	MP0002163_abnormal_gland_morphology	1.50922528
33	MP0005360_urolithiasis	1.40988177
34	MP0005379_endocrine/exocrine_gland_phen	1.40093184
35	MP0008872_abnormal_physiological_respon	1.38634403
36	MP0005253_abnormal_eye_physiology	1.38594153
37	MP0001485_abnormal_pinna_reflex	1.36095337
38	MP0005410_abnormal_fertilization	1.35947049
39	MP0002254_reproductive_system_inflammat	1.30858158
40	MP0004036_abnormal_muscle_relaxation	1.27321254
41	MP0003806_abnormal_nucleotide_metabolis	1.26237547
42	MP0001853_heart_inflammation	1.25579155
43	MP0001348_abnormal_lacrimal_gland	1.25552851
44	MP0003011_delayed_dark_adaptation	1.24731483
45	MP0005423_abnormal_somatic_nervous	1.12984635
46	MP0003943_abnormal_hepatobiliary_system	1.12616298
47	MP0003878_abnormal_ear_physiology	1.09867573
48	MP0005377_hearing/vestibular/ear_phenot	1.09867573
49	MP0008058_abnormal_DNA_repair	1.09346326
50	MP0003279_aneurysm	1.06836961
51	MP0005332_abnormal_amino_acid	1.03460995
52	MP0008775_abnormal_heart_ventricle	1.02555072
53	MP0003252_abnormal_bile_duct	0.99386782
54	MP0001501_abnormal_sleep_pattern	0.98139178
55	MP0001790_abnormal_immune_system	0.96672205
56	MP0005387_immune_system_phenotype	0.96672205
57	MP0002160_abnormal_reproductive_system	0.92480117
58	MP0000371_diluted_coat_color	0.91026699
59	MP0001984_abnormal_olfaction	0.89121269
60	MP0001529_abnormal_vocalization	0.86756327
61	MP0002272_abnormal_nervous_system	0.86752201
62	MP0002933_joint_inflammation	0.86621768
63	MP0002693_abnormal_pancreas_physiology	0.85758346
64	MP0006082_CNS_inflammation	0.82775751
65	MP0000427_abnormal_hair_cycle	0.82750677
66	MP0005671_abnormal_response_to	0.82535185
67	MP0005389_reproductive_system_phenotype	0.82002874
68	MP0006276_abnormal_autonomic_nervous	0.81091240
69	MP0009780_abnormal_chondrocyte_physiolo	0.79870194
70	MP0001873_stomach_inflammation	0.78235922
71	MP0002876_abnormal_thyroid_physiology	0.77566947
72	MP0005623_abnormal_meninges_morphology	0.77157678
73	MP0006036_abnormal_mitochondrial_physio	0.74641543
74	MP0001915_intracranial_hemorrhage	0.74468816
75	MP0003718_maternal_effect	0.74416280
76	MP0006072_abnormal_retinal_apoptosis	0.73225467
77	MP0003633_abnormal_nervous_system	0.72499747
78	MP0001968_abnormal_touch/_nociception	0.71116351
79	MP0001800_abnormal_humoral_immune	0.68772286
80	MP0005647_abnormal_sex_gland	0.68385144
81	MP0005266_abnormal_metabolism	0.68287385
82	MP0002148_abnormal_hypersensitivity_rea	0.67825950
83	MP0003045_fibrosis	0.66750564
84	MP0001324_abnormal_eye_pigmentation	0.65863802
85	MP0004142_abnormal_muscle_tone	0.64303961
86	MP0008877_abnormal_DNA_methylation	0.64215831
87	MP0000230_abnormal_systemic_arterial	0.63126041
88	MP0009046_muscle_twitch	0.61947976
89	MP0003936_abnormal_reproductive_system	0.61180570
90	MP0000749_muscle_degeneration	0.60315731
91	MP0010155_abnormal_intestine_physiology	0.59779016
92	MP0002723_abnormal_immune_serum	0.58490656
93	MP0004742_abnormal_vestibular_system	0.57418256
94	MP0002736_abnormal_nociception_after	0.57366775
95	MP0005376_homeostasis/metabolism_phenot	0.57171043
96	MP0008789_abnormal_olfactory_epithelium	0.55723614
97	MP0001929_abnormal_gametogenesis	0.55553882
98	MP0009745_abnormal_behavioral_response	0.54981074
99	MP0002972_abnormal_cardiac_muscle	0.54155246
100	MP0002735_abnormal_chemical_nociception	0.53760096

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic hepatic failure (HP:0100626)	5.94199181
2	Progressive inability to walk (HP:0002505)	4.47792736
3	Congenital stationary night blindness (HP:0007642)	4.39706182
4	Acute necrotizing encephalopathy (HP:0006965)	3.57380809
5	Acute encephalopathy (HP:0006846)	3.56437483
6	Aplastic anemia (HP:0001915)	3.33701263
7	Progressive macrocephaly (HP:0004481)	3.22100304
8	Pancreatic cysts (HP:0001737)	3.21048503
9	Abnormality of midbrain morphology (HP:0002418)	3.18028383
10	Molar tooth sign on MRI (HP:0002419)	3.18028383
11	Mitochondrial inheritance (HP:0001427)	3.16790057
12	Inability to walk (HP:0002540)	3.14558144
13	Congenital sensorineural hearing impairment (HP:0008527)	3.03595912
14	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.99144792
15	Absent/shortened dynein arms (HP:0200106)	2.99144792
16	Abnormal mitochondria in muscle tissue (HP:0008316)	2.93884886
17	Increased CSF lactate (HP:0002490)	2.92617294
18	Increased hepatocellular lipid droplets (HP:0006565)	2.82857753
19	Hypoplasia of the fovea (HP:0007750)	2.78695136
20	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.78695136
21	Lipid accumulation in hepatocytes (HP:0006561)	2.77577015
22	True hermaphroditism (HP:0010459)	2.74472983
23	Hepatocellular necrosis (HP:0001404)	2.72936599
24	Type 2 muscle fiber atrophy (HP:0003554)	2.68691242
25	Posterior subcapsular cataract (HP:0007787)	2.67247621
26	Popliteal pterygium (HP:0009756)	2.59084538
27	Pancreatic fibrosis (HP:0100732)	2.52421424
28	Horizontal nystagmus (HP:0000666)	2.50258195
29	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.47242222
30	Attenuation of retinal blood vessels (HP:0007843)	2.43594404
31	Chorioretinal atrophy (HP:0000533)	2.39595721
32	Optic disc pallor (HP:0000543)	2.37637944
33	Abnormal gallbladder physiology (HP:0012438)	2.37131172
34	Cholecystitis (HP:0001082)	2.37131172
35	Aplasia/Hypoplasia of the macula (HP:0008059)	2.36959169
36	Tubular atrophy (HP:0000092)	2.35795973
37	Hypoproteinemia (HP:0003075)	2.34570983
38	Stomatitis (HP:0010280)	2.32909112
39	Gaze-evoked nystagmus (HP:0000640)	2.31580537
40	Abnormality of placental membranes (HP:0011409)	2.31029887
41	Amniotic constriction ring (HP:0009775)	2.31029887
42	Medial flaring of the eyebrow (HP:0010747)	2.30212955
43	Ketoacidosis (HP:0001993)	2.28676731
44	Decreased central vision (HP:0007663)	2.27421581
45	Nephronophthisis (HP:0000090)	2.22878029
46	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.20644527
47	Increased serum lactate (HP:0002151)	2.18782051
48	Abnormal respiratory epithelium morphology (HP:0012253)	2.16289217
49	Abnormal respiratory motile cilium morphology (HP:0005938)	2.16289217
50	Type II lissencephaly (HP:0007260)	2.14018643
51	Chromsome breakage (HP:0040012)	2.13314871
52	Hepatic necrosis (HP:0002605)	2.12208305
53	Chronic sinusitis (HP:0011109)	2.10823715
54	Mutism (HP:0002300)	2.10795869
55	Renal Fanconi syndrome (HP:0001994)	2.09636258
56	Abnormality of the fovea (HP:0000493)	2.08735723
57	Dyschromatopsia (HP:0007641)	2.06690697
58	Abnormality of alanine metabolism (HP:0010916)	2.03902683
59	Hyperalaninemia (HP:0003348)	2.03902683
60	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.03902683
61	Hypergonadotropic hypogonadism (HP:0000815)	2.01915978
62	Abnormal ciliary motility (HP:0012262)	1.95486715
63	Cerebral edema (HP:0002181)	1.95297805
64	Spastic paraparesis (HP:0002313)	1.95148937
65	Muscle fiber atrophy (HP:0100295)	1.94926260
66	Median cleft lip (HP:0000161)	1.92115063
67	Loss of speech (HP:0002371)	1.91790486
68	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.88551833
69	Bony spicule pigmentary retinopathy (HP:0007737)	1.87862066
70	Abnormality of the renal medulla (HP:0100957)	1.86367868
71	Abolished electroretinogram (ERG) (HP:0000550)	1.83535383
72	Constricted visual fields (HP:0001133)	1.83433966
73	Severe visual impairment (HP:0001141)	1.83392106
74	Pendular nystagmus (HP:0012043)	1.80426068
75	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.80103225
76	Abnormal number of erythroid precursors (HP:0012131)	1.78024068
77	Chronic otitis media (HP:0000389)	1.77769415
78	Cystic liver disease (HP:0006706)	1.77504645
79	Abnormal respiratory motile cilium physiology (HP:0012261)	1.76667538
80	Abnormality of DNA repair (HP:0003254)	1.76377687
81	Concave nail (HP:0001598)	1.76184682
82	Male pseudohermaphroditism (HP:0000037)	1.74717106
83	Exertional dyspnea (HP:0002875)	1.74376372
84	Metaphyseal dysplasia (HP:0100255)	1.74357374
85	Nephrogenic diabetes insipidus (HP:0009806)	1.74088476
86	Hypothermia (HP:0002045)	1.73815254
87	Bulbous nose (HP:0000414)	1.72852969
88	Abnormal rod and cone electroretinograms (HP:0008323)	1.71383731
89	Congenital primary aphakia (HP:0007707)	1.70626116
90	Rhinitis (HP:0012384)	1.69704700
91	Neonatal respiratory distress (HP:0002643)	1.69568093
92	Birth length less than 3rd percentile (HP:0003561)	1.69533587
93	Thyroiditis (HP:0100646)	1.69128483
94	Albinism (HP:0001022)	1.67695165
95	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.67008917
96	Genetic anticipation (HP:0003743)	1.65913328
97	Decreased circulating renin level (HP:0003351)	1.64416177
98	Abnormality of the pons (HP:0007361)	1.63908019
99	Dyskinesia (HP:0100660)	1.63576164
100	Tachypnea (HP:0002789)	1.62304665

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PASK	4.96427327
2	TXK	3.98411252
3	FRK	3.23312313
4	BMPR1B	3.19038576
5	NEK1	3.18648798
6	MAP3K13	3.13029898
7	MST4	2.65521388
8	ACVR1B	2.61982508
9	NUAK1	2.42149377
10	EIF2AK3	2.33221030
11	EIF2AK1	2.29355408
12	CAMKK1	2.06047733
13	MAP3K12	2.03762186
14	STK38L	2.02968869
15	TRIM28	1.99262132
16	VRK2	1.96047885
17	BRSK2	1.90412908
18	GRK1	1.82890691
19	MUSK	1.70422801
20	ADRBK2	1.68916844
21	LATS1	1.53506264
22	FER	1.52591110
23	MAP4K2	1.46317408
24	STK39	1.46003089
25	MAPKAPK3	1.35449242
26	OXSR1	1.31049088
27	CASK	1.30230029
28	NME1	1.30198844
29	IKBKB	1.28135351
30	INSRR	1.25487781
31	MKNK2	1.21117475
32	TAOK3	1.19198278
33	PAK3	1.17347711
34	GRK5	1.09184386
35	WNK4	1.08934655
36	SIK3	1.07602564
37	TAF1	0.98363371
38	PDK2	0.93214578
39	ZAK	0.92458195
40	WNK3	0.91045019
41	TGFBR1	0.90999961
42	TIE1	0.87204237
43	ADRBK1	0.83768675
44	PLK2	0.83502911
45	BCR	0.82650517
46	CSNK1A1L	0.82305706
47	MST1R	0.82300022
48	WEE1	0.80512793
49	MAPKAPK5	0.79443319
50	DAPK1	0.78369562
51	TSSK6	0.76120186
52	CSNK1G3	0.74250669
53	MARK3	0.73428444
54	PLK3	0.72193011
55	VRK1	0.71525856
56	DAPK2	0.69364931
57	MAP3K14	0.68923496
58	MYLK	0.68257945
59	EIF2AK2	0.66887295
60	PRKCQ	0.63999184
61	AKT3	0.63815431
62	MKNK1	0.63166863
63	MAP4K1	0.60768443
64	CAMKK2	0.60059726
65	PINK1	0.59175901
66	CHUK	0.58928269
67	MAP3K3	0.58253713
68	PRKCI	0.57823940
69	CSNK1G1	0.56993248
70	CSNK1G2	0.56978079
71	DYRK2	0.54603292
72	ITK	0.53816137
73	BRSK1	0.52036355
74	MAPK13	0.49511738
75	PTK2B	0.48157708
76	GRK7	0.46731238
77	STK38	0.46687673
78	CLK1	0.46229416
79	TEC	0.46005914
80	ERBB3	0.45534223
81	TNIK	0.43570193
82	CCNB1	0.41915117
83	LRRK2	0.39482396
84	NEK6	0.39384275
85	STK3	0.38523902
86	NLK	0.36944289
87	PIK3CG	0.36425491
88	PAK6	0.35935808
89	MAP2K1	0.35183728
90	PLK4	0.34907595
91	IGF1R	0.34290906
92	PRKAA2	0.32587032
93	MELK	0.30963117
94	ABL2	0.28863238
95	LCK	0.27871684
96	PRKCE	0.26933651
97	STK10	0.25113091
98	TNK2	0.24648894
99	TGFBR2	0.24043236
100	PIK3CA	0.23739992

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.81033327
2	Caffeine metabolism_Homo sapiens_hsa00232	3.44915575
3	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.13186778
4	Protein export_Homo sapiens_hsa03060	3.04570800
5	Phototransduction_Homo sapiens_hsa04744	2.64000265
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.53105315
7	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.37957967
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.20975626
9	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.17088437
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.11688879
11	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.03714483
12	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.03045200
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.98845633
14	RNA polymerase_Homo sapiens_hsa03020	1.88939317
15	Basal transcription factors_Homo sapiens_hsa03022	1.79041965
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.76313123
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.71824605
18	Oxidative phosphorylation_Homo sapiens_hsa00190	1.52492699
19	One carbon pool by folate_Homo sapiens_hsa00670	1.50257112
20	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.49857884
21	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.49167801
22	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.48830281
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.43369359
24	Primary immunodeficiency_Homo sapiens_hsa05340	1.42499194
25	Homologous recombination_Homo sapiens_hsa03440	1.42364764
26	Glutathione metabolism_Homo sapiens_hsa00480	1.41482463
27	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.40956691
28	Propanoate metabolism_Homo sapiens_hsa00640	1.39293092
29	Steroid biosynthesis_Homo sapiens_hsa00100	1.32265243
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.31682807
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.29833346
32	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.29492360
33	Sulfur metabolism_Homo sapiens_hsa00920	1.27321553
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.24900080
35	RNA degradation_Homo sapiens_hsa03018	1.23240258
36	Parkinsons disease_Homo sapiens_hsa05012	1.21413075
37	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.21334567
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.20046805
39	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.16515220
40	Fanconi anemia pathway_Homo sapiens_hsa03460	1.10252882
41	Ribosome_Homo sapiens_hsa03010	1.09023535
42	Regulation of autophagy_Homo sapiens_hsa04140	1.08452367
43	Olfactory transduction_Homo sapiens_hsa04740	1.02740486
44	Glycerolipid metabolism_Homo sapiens_hsa00561	1.01282214
45	p53 signaling pathway_Homo sapiens_hsa04115	0.94689753
46	Purine metabolism_Homo sapiens_hsa00230	0.93840016
47	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.92465291
48	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.90668934
49	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.89617637
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87803076
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.82289234
52	Tyrosine metabolism_Homo sapiens_hsa00350	0.80063035
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79890270
54	Mineral absorption_Homo sapiens_hsa04978	0.79556374
55	Graft-versus-host disease_Homo sapiens_hsa05332	0.79048746
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.74821009
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.74696025
58	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.74181913
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71681252
60	Allograft rejection_Homo sapiens_hsa05330	0.71311985
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.71019591
62	Pyrimidine metabolism_Homo sapiens_hsa00240	0.70489987
63	Retinol metabolism_Homo sapiens_hsa00830	0.70143944
64	RNA transport_Homo sapiens_hsa03013	0.69913114
65	Metabolic pathways_Homo sapiens_hsa01100	0.69812589
66	Taste transduction_Homo sapiens_hsa04742	0.68979086
67	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.68416557
68	Huntingtons disease_Homo sapiens_hsa05016	0.67982476
69	ABC transporters_Homo sapiens_hsa02010	0.64896095
70	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.63422091
71	Type I diabetes mellitus_Homo sapiens_hsa04940	0.59578380
72	Butanoate metabolism_Homo sapiens_hsa00650	0.58571096
73	Rheumatoid arthritis_Homo sapiens_hsa05323	0.57838910
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55897520
75	Alzheimers disease_Homo sapiens_hsa05010	0.55318362
76	Histidine metabolism_Homo sapiens_hsa00340	0.52227543
77	Measles_Homo sapiens_hsa05162	0.51712564
78	Morphine addiction_Homo sapiens_hsa05032	0.51384986
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49799794
80	Sphingolipid metabolism_Homo sapiens_hsa00600	0.48776077
81	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46454717
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.45515085
83	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.45458263
84	Legionellosis_Homo sapiens_hsa05134	0.44889437
85	Non-homologous end-joining_Homo sapiens_hsa03450	0.44489637
86	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.43819930
87	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.43654046
88	Serotonergic synapse_Homo sapiens_hsa04726	0.42667315
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.41190555
90	Calcium signaling pathway_Homo sapiens_hsa04020	0.41032678
91	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.40452375
92	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.40446481
93	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.39897871
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.39271118
95	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38624573
96	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.36850654
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.35635147
98	Cardiac muscle contraction_Homo sapiens_hsa04260	0.33599605
99	Nicotine addiction_Homo sapiens_hsa05033	0.33561824
100	Salivary secretion_Homo sapiens_hsa04970	0.32921170

LINC00935

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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