ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.91510413
2	L-fucose catabolic process (GO:0042355)	3.90372282
3	fucose catabolic process (GO:0019317)	3.90372282
4	L-fucose metabolic process (GO:0042354)	3.90372282
5	mannosylation (GO:0097502)	3.75273326
6	indolalkylamine metabolic process (GO:0006586)	3.63376272
7	cytidine metabolic process (GO:0046087)	3.62691867
8	cytidine catabolic process (GO:0006216)	3.62691867
9	cytidine deamination (GO:0009972)	3.62691867
10	behavioral response to nicotine (GO:0035095)	3.56531644
11	indolalkylamine catabolic process (GO:0046218)	3.52262971
12	tryptophan catabolic process (GO:0006569)	3.52262971
13	indole-containing compound catabolic process (GO:0042436)	3.52262971
14	response to pheromone (GO:0019236)	3.51372315
15	adaptation of signaling pathway (GO:0023058)	3.49650765
16	respiratory chain complex IV assembly (GO:0008535)	3.46108662
17	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.45801978
18	protein complex biogenesis (GO:0070271)	3.39494501
19	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.35844048
20	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.35596869
21	preassembly of GPI anchor in ER membrane (GO:0016254)	3.34889716
22	tryptophan metabolic process (GO:0006568)	3.32007964
23	platelet dense granule organization (GO:0060155)	3.28779978
24	cellular ketone body metabolic process (GO:0046950)	3.17845216
25	piRNA metabolic process (GO:0034587)	3.15080666
26	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.12679311
27	cytochrome complex assembly (GO:0017004)	3.12006562
28	regulation of B cell receptor signaling pathway (GO:0050855)	3.11104424
29	protein deneddylation (GO:0000338)	3.10716504
30	cullin deneddylation (GO:0010388)	3.10456454
31	mitochondrial respiratory chain complex assembly (GO:0033108)	3.07775048
32	kynurenine metabolic process (GO:0070189)	3.05529827
33	sulfation (GO:0051923)	3.01681600
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.01333205
35	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.01333205
36	NADH dehydrogenase complex assembly (GO:0010257)	3.01333205
37	axoneme assembly (GO:0035082)	3.01212767
38	positive regulation of defense response to virus by host (GO:0002230)	2.98343636
39	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.98016506
40	negative regulation of mast cell activation (GO:0033004)	2.93758795
41	epithelial cilium movement (GO:0003351)	2.82950695
42	ketone body metabolic process (GO:1902224)	2.79789750
43	ubiquinone biosynthetic process (GO:0006744)	2.77152174
44	adenosine metabolic process (GO:0046085)	2.74701728
45	negative T cell selection (GO:0043383)	2.74415770
46	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.70571162
47	GPI anchor metabolic process (GO:0006505)	2.69938652
48	water-soluble vitamin biosynthetic process (GO:0042364)	2.66312978
49	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.64825903
50	multicellular organism reproduction (GO:0032504)	2.63783825
51	negative regulation of execution phase of apoptosis (GO:1900118)	2.63705946
52	regulation of cilium movement (GO:0003352)	2.62462182
53	S-adenosylmethionine metabolic process (GO:0046500)	2.61828241
54	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.57656265
55	regulation of T cell mediated cytotoxicity (GO:0001914)	2.57587456
56	regulation of hexokinase activity (GO:1903299)	2.55571795
57	regulation of glucokinase activity (GO:0033131)	2.55571795
58	indole-containing compound metabolic process (GO:0042430)	2.54623528
59	GPI anchor biosynthetic process (GO:0006506)	2.53809832
60	retinal cone cell development (GO:0046549)	2.51972848
61	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.51643552
62	negative regulation of telomere maintenance (GO:0032205)	2.51518284
63	regulation of defense response to virus by host (GO:0050691)	2.50260553
64	ubiquinone metabolic process (GO:0006743)	2.49972396
65	DNA methylation involved in gamete generation (GO:0043046)	2.46680782
66	negative thymic T cell selection (GO:0045060)	2.46530890
67	metallo-sulfur cluster assembly (GO:0031163)	2.45128571
68	iron-sulfur cluster assembly (GO:0016226)	2.45128571
69	neuronal action potential (GO:0019228)	2.44214578
70	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.43128286
71	ATP synthesis coupled proton transport (GO:0015986)	2.42929959
72	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.42929959
73	detection of light stimulus involved in sensory perception (GO:0050962)	2.42476089
74	detection of light stimulus involved in visual perception (GO:0050908)	2.42476089
75	negative regulation of interleukin-1 beta production (GO:0032691)	2.40266971
76	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.39124235
77	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.38289278
78	response to interferon-beta (GO:0035456)	2.37471723
79	male meiosis (GO:0007140)	2.37458839
80	protein-cofactor linkage (GO:0018065)	2.37159558
81	cellular biogenic amine catabolic process (GO:0042402)	2.36656181
82	amine catabolic process (GO:0009310)	2.36656181
83	primary amino compound metabolic process (GO:1901160)	2.36599768
84	rhodopsin mediated signaling pathway (GO:0016056)	2.36585265
85	negative regulation of interleukin-1 production (GO:0032692)	2.36479795
86	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.36293398
87	cilium movement (GO:0003341)	2.34950592
88	C-terminal protein amino acid modification (GO:0018410)	2.34682102
89	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.33390171
90	rRNA catabolic process (GO:0016075)	2.33094362
91	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.32659013
92	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.32659013
93	cellular response to interleukin-15 (GO:0071350)	2.31537922
94	aromatic amino acid family catabolic process (GO:0009074)	2.31442746
95	NAD biosynthetic process (GO:0009435)	2.31014923
96	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.29946186
97	cellular response to exogenous dsRNA (GO:0071360)	2.29860079
98	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.28281371
99	negative regulation by host of viral transcription (GO:0043922)	2.27864095
100	activated T cell proliferation (GO:0050798)	2.27409855

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.67293675
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.53246950
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.07403994
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.97007586
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.86547335
6	VDR_22108803_ChIP-Seq_LS180_Human	2.64867679
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.53842536
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.36105973
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.14572131
10	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.06315412
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.05977316
12	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.04501792
13	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.99749351
14	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.98496347
15	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.93429662
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.92612871
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.80973242
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.80699550
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.79517924
20	TP53_22573176_ChIP-Seq_HFKS_Human	1.77258650
21	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.76443642
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.76208492
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.72726252
24	P300_19829295_ChIP-Seq_ESCs_Human	1.62631719
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.58387322
26	EWS_26573619_Chip-Seq_HEK293_Human	1.57486933
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.57392846
28	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.56842486
29	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.56842486
30	GATA3_26560356_Chip-Seq_TH2_Human	1.49769910
31	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.49294320
32	EZH2_22144423_ChIP-Seq_EOC_Human	1.48789197
33	VDR_23849224_ChIP-Seq_CD4+_Human	1.43597597
34	AR_20517297_ChIP-Seq_VCAP_Human	1.43326414
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.42709393
36	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.40807801
37	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.40482716
38	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.38057207
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.37922014
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.37423733
41	FUS_26573619_Chip-Seq_HEK293_Human	1.37319643
42	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.36983347
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35286923
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.33510336
45	TAF15_26573619_Chip-Seq_HEK293_Human	1.33087239
46	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.33057072
47	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.32226042
48	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.31846703
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.31693172
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.31693172
51	NANOG_20526341_ChIP-Seq_ESCs_Human	1.30274009
52	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30008518
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29815294
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29815294
55	RUNX_20019798_ChIP-Seq_JUKART_Human	1.29498202
56	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.28474007
57	NCOR_22424771_ChIP-Seq_293T_Human	1.27995555
58	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.26655271
59	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.26581953
60	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.25622313
61	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24075087
62	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.23978444
63	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23604815
64	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.18997866
65	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17730074
66	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.17570097
67	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.16118963
68	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.15961186
69	MYC_19829295_ChIP-Seq_ESCs_Human	1.15415524
70	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15069472
71	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.14957274
72	HOXB7_26014856_ChIP-Seq_BT474_Human	1.13944087
73	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.13838059
74	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13597751
75	AR_25329375_ChIP-Seq_VCAP_Human	1.13071838
76	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11511362
77	GATA3_27048872_Chip-Seq_THYMUS_Human	1.10907196
78	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.09901359
79	HTT_18923047_ChIP-ChIP_STHdh_Human	1.09027333
80	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.07851646
81	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.07253953
82	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.06838148
83	TAF2_19829295_ChIP-Seq_ESCs_Human	1.06172099
84	MYB_26560356_Chip-Seq_TH2_Human	1.05613910
85	ERA_21632823_ChIP-Seq_H3396_Human	1.05310099
86	FOXP3_21729870_ChIP-Seq_TREG_Human	1.03954678
87	OCT4_20526341_ChIP-Seq_ESCs_Human	1.03447579
88	TCF4_23295773_ChIP-Seq_U87_Human	1.02287383
89	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02245049
90	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.99967961
91	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99770611
92	TCF4_22108803_ChIP-Seq_LS180_Human	0.97595488
93	STAT3_23295773_ChIP-Seq_U87_Human	0.97511742
94	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.95544272
95	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95544272
96	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.94495799
97	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.93768836
98	SMAD4_21799915_ChIP-Seq_A2780_Human	0.93177956
99	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.91697038
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.91659281

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.28826656
2	MP0003195_calcinosis	2.85720631
3	MP0002876_abnormal_thyroid_physiology	2.55278185
4	MP0008877_abnormal_DNA_methylation	2.33206615
5	MP0005645_abnormal_hypothalamus_physiol	2.31300137
6	MP0002653_abnormal_ependyma_morphology	2.27880010
7	MP0002837_dystrophic_cardiac_calcinosis	2.24952106
8	MP0003806_abnormal_nucleotide_metabolis	2.07064515
9	MP0008872_abnormal_physiological_respon	2.05107993
10	MP0001835_abnormal_antigen_presentation	2.01191933
11	MP0001968_abnormal_touch/_nociception	2.00237555
12	MP0002102_abnormal_ear_morphology	1.90222265
13	MP0000372_irregular_coat_pigmentation	1.88986209
14	MP0005551_abnormal_eye_electrophysiolog	1.88872615
15	MP0003787_abnormal_imprinting	1.85797801
16	MP0003011_delayed_dark_adaptation	1.85130796
17	MP0006072_abnormal_retinal_apoptosis	1.82551634
18	MP0000569_abnormal_digit_pigmentation	1.78707356
19	MP0001986_abnormal_taste_sensitivity	1.78094200
20	MP0004147_increased_porphyrin_level	1.76296693
21	MP0008875_abnormal_xenobiotic_pharmacok	1.74697227
22	MP0005075_abnormal_melanosome_morpholog	1.69386714
23	MP0002163_abnormal_gland_morphology	1.64652390
24	MP0002138_abnormal_hepatobiliary_system	1.64207192
25	MP0009785_altered_susceptibility_to	1.63508345
26	MP0002277_abnormal_respiratory_mucosa	1.57552591
27	MP0005379_endocrine/exocrine_gland_phen	1.54905513
28	MP0001800_abnormal_humoral_immune	1.52479305
29	MP0003646_muscle_fatigue	1.50039503
30	MP0005174_abnormal_tail_pigmentation	1.49771571
31	MP0002693_abnormal_pancreas_physiology	1.48368630
32	MP0002148_abnormal_hypersensitivity_rea	1.47075566
33	MP0001501_abnormal_sleep_pattern	1.46170786
34	MP0009046_muscle_twitch	1.43587872
35	MP0005253_abnormal_eye_physiology	1.38255485
36	MP0001984_abnormal_olfaction	1.37837468
37	MP0004142_abnormal_muscle_tone	1.36039187
38	MP0000685_abnormal_immune_system	1.35665731
39	MP0005084_abnormal_gallbladder_morpholo	1.35077612
40	MP0001905_abnormal_dopamine_level	1.34877381
41	MP0005646_abnormal_pituitary_gland	1.32905630
42	MP0002723_abnormal_immune_serum	1.30396965
43	MP0000427_abnormal_hair_cycle	1.29191203
44	MP0001790_abnormal_immune_system	1.24537599
45	MP0005387_immune_system_phenotype	1.24537599
46	MP0001485_abnormal_pinna_reflex	1.21861266
47	MP0002420_abnormal_adaptive_immunity	1.21672856
48	MP0005410_abnormal_fertilization	1.21571965
49	MP0001819_abnormal_immune_cell	1.21037224
50	MP0005000_abnormal_immune_tolerance	1.20216296
51	MP0008995_early_reproductive_senescence	1.19543933
52	MP0005389_reproductive_system_phenotype	1.19525139
53	MP0009745_abnormal_behavioral_response	1.17174523
54	MP0003763_abnormal_thymus_physiology	1.17110146
55	MP0001873_stomach_inflammation	1.15573785
56	MP0002452_abnormal_antigen_presenting	1.15305049
57	MP0000230_abnormal_systemic_arterial	1.14699905
58	MP0002160_abnormal_reproductive_system	1.13963103
59	MP0006036_abnormal_mitochondrial_physio	1.12948307
60	MP0003724_increased_susceptibility_to	1.07484902
61	MP0002928_abnormal_bile_duct	1.04803617
62	MP0002736_abnormal_nociception_after	1.03996861
63	MP0004145_abnormal_muscle_electrophysio	1.02856434
64	MP0002272_abnormal_nervous_system	1.02785623
65	MP0005332_abnormal_amino_acid	1.00253846
66	MP0001919_abnormal_reproductive_system	0.99409979
67	MP0003786_premature_aging	0.99365408
68	MP0008775_abnormal_heart_ventricle	0.98929815
69	MP0006082_CNS_inflammation	0.98278526
70	MP0002638_abnormal_pupillary_reflex	0.98203183
71	MP0002735_abnormal_chemical_nociception	0.97774765
72	MP0002733_abnormal_thermal_nociception	0.96175861
73	MP0002405_respiratory_system_inflammati	0.96146147
74	MP0003136_yellow_coat_color	0.95519292
75	MP0006276_abnormal_autonomic_nervous	0.95147696
76	MP0005025_abnormal_response_to	0.93806180
77	MP0009764_decreased_sensitivity_to	0.92745709
78	MP0002557_abnormal_social/conspecific_i	0.92158419
79	MP0000716_abnormal_immune_system	0.91711188
80	MP0002095_abnormal_skin_pigmentation	0.90825273
81	MP0009333_abnormal_splenocyte_physiolog	0.90004006
82	MP0005220_abnormal_exocrine_pancreas	0.89708685
83	MP0005310_abnormal_salivary_gland	0.88915595
84	MP0010386_abnormal_urinary_bladder	0.88648602
85	MP0000631_abnormal_neuroendocrine_gland	0.87642796
86	MP0006292_abnormal_olfactory_placode	0.86655555
87	MP0001944_abnormal_pancreas_morphology	0.86126812
88	MP0003638_abnormal_response/metabolism_	0.85363006
89	MP0003283_abnormal_digestive_organ	0.85060779
90	MP0004043_abnormal_pH_regulation	0.83976530
91	MP0002572_abnormal_emotion/affect_behav	0.83608506
92	MP0003252_abnormal_bile_duct	0.83238334
93	MP0000689_abnormal_spleen_morphology	0.83148978
94	MP0010329_abnormal_lipoprotein_level	0.82991469
95	MP0001929_abnormal_gametogenesis	0.82609677
96	MP0001970_abnormal_pain_threshold	0.81354020
97	MP0001765_abnormal_ion_homeostasis	0.79418550
98	MP0005448_abnormal_energy_balance	0.78412693
99	MP0004133_heterotaxia	0.76276238
100	MP0001529_abnormal_vocalization	0.75775316

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.86852712
2	Congenital stationary night blindness (HP:0007642)	3.50153727
3	Pancreatic fibrosis (HP:0100732)	3.44696079
4	Type II lissencephaly (HP:0007260)	3.41225436
5	Abnormality of midbrain morphology (HP:0002418)	3.25694105
6	Molar tooth sign on MRI (HP:0002419)	3.25694105
7	True hermaphroditism (HP:0010459)	3.24121001
8	3-Methylglutaconic aciduria (HP:0003535)	3.05842142
9	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.05353792
10	Absent/shortened dynein arms (HP:0200106)	3.05353792
11	Attenuation of retinal blood vessels (HP:0007843)	2.90449810
12	Mitochondrial inheritance (HP:0001427)	2.81628835
13	Nephronophthisis (HP:0000090)	2.78130264
14	Hypothermia (HP:0002045)	2.73874025
15	Lipid accumulation in hepatocytes (HP:0006561)	2.73190772
16	Abnormality of the renal cortex (HP:0011035)	2.72779934
17	Stomatitis (HP:0010280)	2.69411537
18	Abolished electroretinogram (ERG) (HP:0000550)	2.68684283
19	Hyperalaninemia (HP:0003348)	2.64264356
20	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.64264356
21	Abnormality of alanine metabolism (HP:0010916)	2.64264356
22	Increased CSF lactate (HP:0002490)	2.61433607
23	Increased hepatocellular lipid droplets (HP:0006565)	2.56448681
24	Hepatocellular necrosis (HP:0001404)	2.55365821
25	Renal cortical cysts (HP:0000803)	2.55056399
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.54037692
27	Polydipsia (HP:0001959)	2.47826295
28	Abnormal drinking behavior (HP:0030082)	2.47826295
29	Cerebellar dysplasia (HP:0007033)	2.45450916
30	Renal Fanconi syndrome (HP:0001994)	2.43987288
31	Elevated erythrocyte sedimentation rate (HP:0003565)	2.41671698
32	IgG deficiency (HP:0004315)	2.41148315
33	Thyroiditis (HP:0100646)	2.39845520
34	Hepatic necrosis (HP:0002605)	2.37915112
35	Severe combined immunodeficiency (HP:0004430)	2.37711858
36	Acute necrotizing encephalopathy (HP:0006965)	2.37071743
37	Abnormality of the renal medulla (HP:0100957)	2.35025126
38	Medial flaring of the eyebrow (HP:0010747)	2.34260582
39	Abnormal biliary tract physiology (HP:0012439)	2.33997393
40	Bile duct proliferation (HP:0001408)	2.33997393
41	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.32125198
42	Abnormal respiratory motile cilium morphology (HP:0005938)	2.25376918
43	Abnormal respiratory epithelium morphology (HP:0012253)	2.25376918
44	Abnormal ciliary motility (HP:0012262)	2.24586493
45	Congenital, generalized hypertrichosis (HP:0004540)	2.23621403
46	Large for gestational age (HP:0001520)	2.18156352
47	Abnormality of the pons (HP:0007361)	2.17702303
48	Progressive macrocephaly (HP:0004481)	2.16931058
49	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.16871581
50	Cystic liver disease (HP:0006706)	2.16767413
51	Methylmalonic acidemia (HP:0002912)	2.15324846
52	Hypoproteinemia (HP:0003075)	2.14564333
53	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.13344645
54	Stomach cancer (HP:0012126)	2.12973515
55	Abnormality of T cell number (HP:0011839)	2.11316513
56	Retrobulbar optic neuritis (HP:0100654)	2.11276247
57	Optic neuritis (HP:0100653)	2.11276247
58	Chronic hepatic failure (HP:0100626)	2.10468462
59	Hypoplasia of the pons (HP:0012110)	2.09678375
60	Abnormal mitochondria in muscle tissue (HP:0008316)	2.09336632
61	Tubular atrophy (HP:0000092)	2.08651252
62	Increased intramyocellular lipid droplets (HP:0012240)	2.05898427
63	Abnormality of eosinophils (HP:0001879)	2.04654482
64	Myositis (HP:0100614)	2.03801978
65	Abnormality of T cells (HP:0002843)	2.02490466
66	Hyperventilation (HP:0002883)	2.02296833
67	Progressive inability to walk (HP:0002505)	2.01727187
68	Encephalitis (HP:0002383)	2.00986517
69	Hypoalbuminemia (HP:0003073)	2.00193437
70	Abnormal albumin level (HP:0012116)	2.00193437
71	Acute encephalopathy (HP:0006846)	1.99636900
72	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.97740455
73	Asplenia (HP:0001746)	1.97622662
74	Polyuria (HP:0000103)	1.97288598
75	Panhypogammaglobulinemia (HP:0003139)	1.96855973
76	Optic disc pallor (HP:0000543)	1.96785907
77	Type I transferrin isoform profile (HP:0003642)	1.95958250
78	Exertional dyspnea (HP:0002875)	1.95677737
79	Abnormal respiratory motile cilium physiology (HP:0012261)	1.94853792
80	Methylmalonic aciduria (HP:0012120)	1.94120053
81	Inability to walk (HP:0002540)	1.93627837
82	Ketoacidosis (HP:0001993)	1.91505216
83	Increased muscle lipid content (HP:0009058)	1.91403911
84	Abnormality of T cell physiology (HP:0011840)	1.90388676
85	T lymphocytopenia (HP:0005403)	1.89760732
86	Increased corneal curvature (HP:0100692)	1.88858704
87	Keratoconus (HP:0000563)	1.88858704
88	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.88133123
89	Sclerocornea (HP:0000647)	1.86561257
90	Ketosis (HP:0001946)	1.85768366
91	Constricted visual fields (HP:0001133)	1.85337856
92	Mesangial abnormality (HP:0001966)	1.84870532
93	Male pseudohermaphroditism (HP:0000037)	1.84069417
94	Bony spicule pigmentary retinopathy (HP:0007737)	1.83075476
95	Concave nail (HP:0001598)	1.81378890
96	Gaze-evoked nystagmus (HP:0000640)	1.81225383
97	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.80116212
98	Abnormal protein N-linked glycosylation (HP:0012347)	1.80116212
99	Abnormal protein glycosylation (HP:0012346)	1.80116212
100	Abnormal glycosylation (HP:0012345)	1.80116212

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.75961889
2	BMPR1B	3.35493613
3	ADRBK2	3.15741323
4	TAOK3	3.13707090
5	ZAK	3.07359812
6	MAP4K2	2.81567371
7	TLK1	2.80651548
8	NUAK1	2.71652421
9	TXK	2.69155622
10	INSRR	2.50736829
11	GRK1	2.38078504
12	PINK1	2.03676422
13	MAP4K1	1.93685214
14	VRK2	1.93083300
15	WNK4	1.67665910
16	TESK2	1.66574540
17	STK16	1.53951334
18	WNK3	1.48846945
19	MUSK	1.48778390
20	MAPK13	1.38872544
21	MAP2K6	1.36870820
22	OXSR1	1.36459319
23	TEC	1.28004877
24	KIT	1.25542531
25	CAMKK2	1.25181645
26	ITK	1.24801624
27	IKBKB	1.21826444
28	GRK6	1.20068924
29	KDR	1.19627228
30	ACVR1B	1.18325643
31	PRKCQ	1.11193550
32	BCKDK	1.10851207
33	TNK2	1.10693147
34	VRK1	1.08237314
35	SYK	1.06724561
36	STK39	1.04933302
37	DAPK2	0.99708356
38	MAPKAPK3	0.98255684
39	TRIM28	0.97457275
40	MAP3K13	0.97334132
41	IKBKE	0.96739418
42	OBSCN	0.96568888
43	ADRBK1	0.96235790
44	LIMK1	0.94131004
45	PHKG1	0.92542896
46	PHKG2	0.92542896
47	TGFBR1	0.91920450
48	BTK	0.90937752
49	PAK3	0.89804869
50	MST4	0.89546042
51	NLK	0.86109748
52	FES	0.80328410
53	STK38L	0.79287040
54	PRKCE	0.76409410
55	LCK	0.73527728
56	LYN	0.72822794
57	FGFR2	0.72697114
58	TIE1	0.71060467
59	MAPK15	0.68633012
60	PIK3CG	0.67938853
61	RPS6KA5	0.67537813
62	PIK3CA	0.67244378
63	CSF1R	0.66115665
64	IRAK1	0.63614273
65	MARK3	0.57549646
66	CSNK1G3	0.55683749
67	CHUK	0.54958632
68	PRKCI	0.54890160
69	CSNK1G1	0.54587182
70	CSNK1G2	0.54132928
71	MAPKAPK5	0.52133860
72	PTK2B	0.51696105
73	GRK7	0.51507182
74	TNIK	0.50956128
75	PRKCH	0.49300151
76	TRPM7	0.49258787
77	MAP3K12	0.47977259
78	PRKCG	0.46795945
79	BLK	0.46780187
80	TBK1	0.46234833
81	EPHA3	0.43461737
82	PKN1	0.41469600
83	CDK19	0.41332910
84	PIM1	0.40508353
85	ZAP70	0.40183589
86	CDK8	0.39483968
87	PIM2	0.38072744
88	DYRK2	0.36958104
89	MATK	0.36766077
90	PRKACA	0.36620594
91	GRK5	0.36571871
92	CAMK2A	0.36232874
93	PRKD2	0.34193602
94	PRKCA	0.33494147
95	MAP2K2	0.33046255
96	CSNK1A1	0.30825420
97	ABL1	0.29842694
98	PLK2	0.28545512
99	CAMK1	0.28511100
100	STK11	0.27578420

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	2.97204001
2	Phototransduction_Homo sapiens_hsa04744	2.60764709
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.56606357
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.55004457
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.46291791
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.38671984
7	Butanoate metabolism_Homo sapiens_hsa00650	2.25927598
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.24554041
9	Asthma_Homo sapiens_hsa05310	2.22569718
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.21318681
11	Allograft rejection_Homo sapiens_hsa05330	2.17698350
12	Graft-versus-host disease_Homo sapiens_hsa05332	2.15915554
13	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.13126677
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.06546132
15	Linoleic acid metabolism_Homo sapiens_hsa00591	2.06030915
16	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.96471520
17	Parkinsons disease_Homo sapiens_hsa05012	1.91290898
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.75665577
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.72613702
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.65778297
21	RNA polymerase_Homo sapiens_hsa03020	1.65048553
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.62848970
23	Protein export_Homo sapiens_hsa03060	1.62642159
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.58578417
25	Homologous recombination_Homo sapiens_hsa03440	1.51095938
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.46773527
27	Caffeine metabolism_Homo sapiens_hsa00232	1.40862008
28	Peroxisome_Homo sapiens_hsa04146	1.40841530
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.33976443
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.33345833
31	Antigen processing and presentation_Homo sapiens_hsa04612	1.30396594
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.29246508
33	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.28601574
34	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.27032739
35	Basal transcription factors_Homo sapiens_hsa03022	1.20476655
36	Alzheimers disease_Homo sapiens_hsa05010	1.20076110
37	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.19454375
38	Olfactory transduction_Homo sapiens_hsa04740	1.18955745
39	Proteasome_Homo sapiens_hsa03050	1.17347193
40	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.16897189
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.15320933
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.15137252
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.13171895
44	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.11598135
45	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.09891399
46	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.09270045
47	Huntingtons disease_Homo sapiens_hsa05016	1.07666741
48	Propanoate metabolism_Homo sapiens_hsa00640	1.06352347
49	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.02936792
50	Chemical carcinogenesis_Homo sapiens_hsa05204	1.02861977
51	ABC transporters_Homo sapiens_hsa02010	1.02769425
52	Ether lipid metabolism_Homo sapiens_hsa00565	1.01998334
53	One carbon pool by folate_Homo sapiens_hsa00670	0.96793722
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.96340359
55	Rheumatoid arthritis_Homo sapiens_hsa05323	0.93359748
56	Retinol metabolism_Homo sapiens_hsa00830	0.87723699
57	Cardiac muscle contraction_Homo sapiens_hsa04260	0.85923557
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.84621693
59	Taste transduction_Homo sapiens_hsa04742	0.81622354
60	Regulation of autophagy_Homo sapiens_hsa04140	0.78450881
61	RNA degradation_Homo sapiens_hsa03018	0.75200103
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74145725
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.73946809
64	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.73538156
65	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.71664740
66	Ribosome_Homo sapiens_hsa03010	0.67244679
67	Purine metabolism_Homo sapiens_hsa00230	0.64910473
68	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.61759754
69	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.61631176
70	Morphine addiction_Homo sapiens_hsa05032	0.60689853
71	Collecting duct acid secretion_Homo sapiens_hsa04966	0.59272307
72	Nicotine addiction_Homo sapiens_hsa05033	0.58078660
73	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.57571914
74	Metabolic pathways_Homo sapiens_hsa01100	0.56795721
75	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.56346810
76	Pyrimidine metabolism_Homo sapiens_hsa00240	0.52435637
77	Sulfur metabolism_Homo sapiens_hsa00920	0.51846065
78	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.50871740
79	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.49785447
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49562527
81	Serotonergic synapse_Homo sapiens_hsa04726	0.48957233
82	Insulin secretion_Homo sapiens_hsa04911	0.46329695
83	Histidine metabolism_Homo sapiens_hsa00340	0.45727441
84	Calcium signaling pathway_Homo sapiens_hsa04020	0.43976102
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.43900005
86	Base excision repair_Homo sapiens_hsa03410	0.43804198
87	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.43287560
88	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.41931859
89	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.40382869
90	Mineral absorption_Homo sapiens_hsa04978	0.40376641
91	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.39473865
92	beta-Alanine metabolism_Homo sapiens_hsa00410	0.38810397
93	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.37057405
94	Circadian entrainment_Homo sapiens_hsa04713	0.35206155
95	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.33728854
96	Fatty acid elongation_Homo sapiens_hsa00062	0.31493816
97	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.30702987
98	Salivary secretion_Homo sapiens_hsa04970	0.30214018
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.29989831
100	Sulfur relay system_Homo sapiens_hsa04122	0.29111480

LINC00959

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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