ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.00902057
2	protein polyglutamylation (GO:0018095)	4.07772708
3	regulation of cilium movement (GO:0003352)	3.85779472
4	DNA deamination (GO:0045006)	3.81202753
5	platelet dense granule organization (GO:0060155)	3.81065890
6	dopamine transport (GO:0015872)	3.68875643
7	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.65092639
8	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.57955289
9	retinal cone cell development (GO:0046549)	3.55408752
10	pyrimidine nucleobase catabolic process (GO:0006208)	3.49075140
11	fucose catabolic process (GO:0019317)	3.46672025
12	L-fucose metabolic process (GO:0042354)	3.46672025
13	L-fucose catabolic process (GO:0042355)	3.46672025
14	axoneme assembly (GO:0035082)	3.45569387
15	gamma-aminobutyric acid transport (GO:0015812)	3.45278164
16	protein-cofactor linkage (GO:0018065)	3.44973124
17	response to pheromone (GO:0019236)	3.43862126
18	epithelial cilium movement (GO:0003351)	3.19824633
19	organic cation transport (GO:0015695)	3.16632528
20	indole-containing compound catabolic process (GO:0042436)	3.12528158
21	indolalkylamine catabolic process (GO:0046218)	3.12528158
22	tryptophan catabolic process (GO:0006569)	3.12528158
23	kidney morphogenesis (GO:0060993)	3.12315891
24	cell wall macromolecule metabolic process (GO:0044036)	3.10787922
25	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.09444954
26	indolalkylamine metabolic process (GO:0006586)	3.06149567
27	regulation of microtubule-based movement (GO:0060632)	3.03417025
28	multicellular organism reproduction (GO:0032504)	3.01795809
29	cAMP catabolic process (GO:0006198)	3.01542437
30	protein localization to cilium (GO:0061512)	3.00099036
31	cilium morphogenesis (GO:0060271)	2.97992940
32	nucleobase catabolic process (GO:0046113)	2.97856818
33	nonmotile primary cilium assembly (GO:0035058)	2.95033698
34	cellular ketone body metabolic process (GO:0046950)	2.94658056
35	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.88307345
36	regulation of hexokinase activity (GO:1903299)	2.86410465
37	regulation of glucokinase activity (GO:0033131)	2.86410465
38	somite development (GO:0061053)	2.85623757
39	piRNA metabolic process (GO:0034587)	2.85506836
40	photoreceptor cell maintenance (GO:0045494)	2.85379114
41	ketone body metabolic process (GO:1902224)	2.82728839
42	neuronal action potential (GO:0019228)	2.82315731
43	adaptation of signaling pathway (GO:0023058)	2.80123059
44	detection of light stimulus involved in visual perception (GO:0050908)	2.79157850
45	detection of light stimulus involved in sensory perception (GO:0050962)	2.79157850
46	sperm motility (GO:0030317)	2.71621142
47	regulation of action potential (GO:0098900)	2.71229679
48	behavioral response to ethanol (GO:0048149)	2.68920593
49	nephron tubule morphogenesis (GO:0072078)	2.68361075
50	nephron epithelium morphogenesis (GO:0072088)	2.68361075
51	positive regulation of glycolytic process (GO:0045821)	2.67764681
52	sulfation (GO:0051923)	2.67609391
53	tryptophan metabolic process (GO:0006568)	2.67391263
54	protein complex biogenesis (GO:0070271)	2.64736593
55	water-soluble vitamin biosynthetic process (GO:0042364)	2.62007648
56	cyclic nucleotide catabolic process (GO:0009214)	2.59751481
57	peptidyl-histidine modification (GO:0018202)	2.58550955
58	photoreceptor cell development (GO:0042461)	2.58036299
59	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.57733228
60	L-methionine salvage (GO:0071267)	2.55244999
61	L-methionine biosynthetic process (GO:0071265)	2.55244999
62	amino acid salvage (GO:0043102)	2.55244999
63	kynurenine metabolic process (GO:0070189)	2.54459380
64	amine catabolic process (GO:0009310)	2.54305454
65	cellular biogenic amine catabolic process (GO:0042402)	2.54305454
66	synaptic transmission, cholinergic (GO:0007271)	2.54107814
67	acrosome reaction (GO:0007340)	2.53869432
68	NADH dehydrogenase complex assembly (GO:0010257)	2.48665566
69	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.48665566
70	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.48665566
71	limb bud formation (GO:0060174)	2.48243572
72	neural tube formation (GO:0001841)	2.47592584
73	respiratory chain complex IV assembly (GO:0008535)	2.47462969
74	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.46297830
75	negative regulation of telomere maintenance (GO:0032205)	2.45994098
76	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.45870758
77	renal tubule morphogenesis (GO:0061333)	2.45846312
78	cornea development in camera-type eye (GO:0061303)	2.45718218
79	cilium organization (GO:0044782)	2.44264054
80	positive regulation of guanylate cyclase activity (GO:0031284)	2.41473866
81	cilium movement (GO:0003341)	2.41377371
82	arginine catabolic process (GO:0006527)	2.40723353
83	mitochondrial respiratory chain complex assembly (GO:0033108)	2.39418818
84	neuronal action potential propagation (GO:0019227)	2.38331488
85	positive regulation of fatty acid transport (GO:2000193)	2.37268711
86	neuron cell-cell adhesion (GO:0007158)	2.36761945
87	inner ear receptor stereocilium organization (GO:0060122)	2.36627378
88	regulation of isotype switching to IgG isotypes (GO:0048302)	2.34687338
89	S-adenosylmethionine metabolic process (GO:0046500)	2.34301609
90	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.34224503
91	inositol phosphate catabolic process (GO:0071545)	2.32986305
92	presynaptic membrane assembly (GO:0097105)	2.32875924
93	nitric oxide mediated signal transduction (GO:0007263)	2.32715601
94	cilium assembly (GO:0042384)	2.32472852
95	indole-containing compound metabolic process (GO:0042430)	2.31609372
96	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.31343597
97	brain morphogenesis (GO:0048854)	2.30672582
98	mannosylation (GO:0097502)	2.30603338
99	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.29748395
100	cellular response to zinc ion (GO:0071294)	2.29491521

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.70702661
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.49909064
3	VDR_22108803_ChIP-Seq_LS180_Human	2.92685041
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.92384191
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.81881727
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.79362519
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.64930943
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.56196275
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.36575943
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.26833967
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.23118425
12	P300_19829295_ChIP-Seq_ESCs_Human	2.13749862
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.10657825
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06482365
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.05948178
16	FUS_26573619_Chip-Seq_HEK293_Human	1.93062018
17	EWS_26573619_Chip-Seq_HEK293_Human	1.88305148
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.86243455
19	BCAT_22108803_ChIP-Seq_LS180_Human	1.81359500
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.75869624
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.72096248
22	CBP_20019798_ChIP-Seq_JUKART_Human	1.65902407
23	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.65902407
24	AR_21572438_ChIP-Seq_LNCaP_Human	1.65271622
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.59216513
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.57835997
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.57143541
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.54750439
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54022837
30	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.51074032
31	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.50676154
32	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49214605
33	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.49047819
34	SOX2_19829295_ChIP-Seq_ESCs_Human	1.48220194
35	NANOG_19829295_ChIP-Seq_ESCs_Human	1.48220194
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.46261890
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.43270462
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43124772
39	STAT3_23295773_ChIP-Seq_U87_Human	1.40637081
40	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.40187040
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.39749009
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.39214419
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38847384
44	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.38847384
45	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.38830259
46	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.38126030
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35963895
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35870178
49	AR_25329375_ChIP-Seq_VCAP_Human	1.33587209
50	TCF4_23295773_ChIP-Seq_U87_Human	1.33063480
51	REST_21632747_ChIP-Seq_MESCs_Mouse	1.31890280
52	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30933882
53	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.30381702
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.27625795
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26956519
56	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.26076704
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25900975
58	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.24231974
59	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24020162
60	RNF2_27304074_Chip-Seq_NSC_Mouse	1.23417238
61	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.22962792
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.22931473
63	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.18323918
64	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.17784053
65	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17703039
66	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17022057
67	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16287443
68	NCOR_22424771_ChIP-Seq_293T_Human	1.15966400
69	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11371351
70	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11371351
71	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.11132676
72	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.10447050
73	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10398667
74	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.10299228
75	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10241925
76	MYC_18940864_ChIP-ChIP_HL60_Human	1.09618389
77	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.09221571
78	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08794982
79	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08317990
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07740863
81	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05699989
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05645595
83	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05410102
84	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.04768910
85	AR_20517297_ChIP-Seq_VCAP_Human	1.04619329
86	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.03649415
87	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.02706470
88	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.02447638
89	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.02146987
90	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.01341494
91	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.01171293
92	CDX2_22108803_ChIP-Seq_LS180_Human	1.00986410
93	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.00902748
94	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99355335
95	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.99124227
96	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.98577159
97	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.98050529
98	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.97787064
99	P53_22387025_ChIP-Seq_ESCs_Mouse	0.97537832
100	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97454928

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	2.68236705
2	MP0001984_abnormal_olfaction	2.65744555
3	MP0004885_abnormal_endolymph	2.46273770
4	MP0002102_abnormal_ear_morphology	2.39676208
5	MP0005551_abnormal_eye_electrophysiolog	2.34531790
6	MP0005084_abnormal_gallbladder_morpholo	2.32280908
7	MP0001968_abnormal_touch/_nociception	2.23937202
8	MP0002736_abnormal_nociception_after	2.11373295
9	MP0002638_abnormal_pupillary_reflex	2.10327956
10	MP0004142_abnormal_muscle_tone	2.04441200
11	MP0005253_abnormal_eye_physiology	2.03127492
12	MP0008877_abnormal_DNA_methylation	2.00200531
13	MP0001529_abnormal_vocalization	1.97309168
14	MP0002876_abnormal_thyroid_physiology	1.94423635
15	MP0005646_abnormal_pituitary_gland	1.92261512
16	MP0006072_abnormal_retinal_apoptosis	1.89343895
17	MP0003011_delayed_dark_adaptation	1.88519874
18	MP0009745_abnormal_behavioral_response	1.87582857
19	MP0004147_increased_porphyrin_level	1.86566412
20	MP0005645_abnormal_hypothalamus_physiol	1.83888485
21	MP0005167_abnormal_blood-brain_barrier	1.82139351
22	MP0000569_abnormal_digit_pigmentation	1.80967595
23	MP0000372_irregular_coat_pigmentation	1.75935354
24	MP0003195_calcinosis	1.75755859
25	MP0003136_yellow_coat_color	1.73437114
26	MP0004215_abnormal_myocardial_fiber	1.70195995
27	MP0004145_abnormal_muscle_electrophysio	1.68928456
28	MP0002272_abnormal_nervous_system	1.65612667
29	MP0003787_abnormal_imprinting	1.61183177
30	MP0006276_abnormal_autonomic_nervous	1.57279165
31	MP0005410_abnormal_fertilization	1.56963764
32	MP0003646_muscle_fatigue	1.56449423
33	MP0001986_abnormal_taste_sensitivity	1.51753166
34	MP0009046_muscle_twitch	1.51687504
35	MP0001486_abnormal_startle_reflex	1.49530777
36	MP0001501_abnormal_sleep_pattern	1.43184316
37	MP0002572_abnormal_emotion/affect_behav	1.40556707
38	MP0004084_abnormal_cardiac_muscle	1.37900348
39	MP0000013_abnormal_adipose_tissue	1.37613873
40	MP0000631_abnormal_neuroendocrine_gland	1.37191899
41	MP0004133_heterotaxia	1.35470983
42	MP0003880_abnormal_central_pattern	1.35219510
43	MP0001485_abnormal_pinna_reflex	1.29819524
44	MP0001905_abnormal_dopamine_level	1.29469341
45	MP0000749_muscle_degeneration	1.29327084
46	MP0003122_maternal_imprinting	1.26460787
47	MP0002938_white_spotting	1.25234705
48	MP0008872_abnormal_physiological_respon	1.23479125
49	MP0008875_abnormal_xenobiotic_pharmacok	1.22242869
50	MP0004924_abnormal_behavior	1.19512802
51	MP0005386_behavior/neurological_phenoty	1.19512802
52	MP0002064_seizures	1.19384013
53	MP0008775_abnormal_heart_ventricle	1.18875891
54	MP0003718_maternal_effect	1.18022578
55	MP0001502_abnormal_circadian_rhythm	1.17195930
56	MP0003137_abnormal_impulse_conducting	1.16857510
57	MP0000230_abnormal_systemic_arterial	1.13948935
58	MP0008789_abnormal_olfactory_epithelium	1.13856925
59	MP0000427_abnormal_hair_cycle	1.10976847
60	MP0005075_abnormal_melanosome_morpholog	1.10439179
61	MP0002928_abnormal_bile_duct	1.09776005
62	MP0003635_abnormal_synaptic_transmissio	1.08875769
63	MP0002733_abnormal_thermal_nociception	1.08817763
64	MP0002067_abnormal_sensory_capabilities	1.08513886
65	MP0004085_abnormal_heartbeat	1.08224796
66	MP0005171_absent_coat_pigmentation	1.00451883
67	MP0002132_abnormal_respiratory_system	1.00208879
68	MP0003121_genomic_imprinting	0.99941512
69	MP0002653_abnormal_ependyma_morphology	0.99856420
70	MP0002160_abnormal_reproductive_system	0.99068874
71	MP0001970_abnormal_pain_threshold	0.99050216
72	MP0002557_abnormal_social/conspecific_i	0.98964714
73	MP0000778_abnormal_nervous_system	0.98492737
74	MP0004484_altered_response_of	0.98263844
75	MP0002234_abnormal_pharynx_morphology	0.97890077
76	MP0005195_abnormal_posterior_eye	0.95995015
77	MP0002735_abnormal_chemical_nociception	0.95108771
78	MP0010368_abnormal_lymphatic_system	0.94776425
79	MP0002751_abnormal_autonomic_nervous	0.92872654
80	MP0004043_abnormal_pH_regulation	0.91678320
81	MP0002063_abnormal_learning/memory/cond	0.90079994
82	MP0005174_abnormal_tail_pigmentation	0.89980882
83	MP0002752_abnormal_somatic_nervous	0.89250664
84	MP0003045_fibrosis	0.88544092
85	MP0002184_abnormal_innervation	0.85863699
86	MP0001879_abnormal_lymphatic_vessel	0.85512786
87	MP0002277_abnormal_respiratory_mucosa	0.85487465
88	MP0004742_abnormal_vestibular_system	0.85415373
89	MP0009697_abnormal_copulation	0.85313843
90	MP0003698_abnormal_male_reproductive	0.84671979
91	MP0001764_abnormal_homeostasis	0.83241936
92	MP0005423_abnormal_somatic_nervous	0.82772403
93	MP0002138_abnormal_hepatobiliary_system	0.80699059
94	MP0005499_abnormal_olfactory_system	0.80650554
95	MP0005394_taste/olfaction_phenotype	0.80650554
96	MP0000026_abnormal_inner_ear	0.79063850
97	MP0005391_vision/eye_phenotype	0.77788374
98	MP0003283_abnormal_digestive_organ	0.77342547
99	MP0001929_abnormal_gametogenesis	0.76685969
100	MP0005620_abnormal_muscle_contractility	0.76537308

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.09679226
2	Molar tooth sign on MRI (HP:0002419)	4.00898914
3	Abnormality of midbrain morphology (HP:0002418)	4.00898914
4	Pancreatic fibrosis (HP:0100732)	3.65522074
5	Type II lissencephaly (HP:0007260)	3.63566217
6	True hermaphroditism (HP:0010459)	3.62118385
7	Nephronophthisis (HP:0000090)	3.61358377
8	Abnormality of the renal cortex (HP:0011035)	3.51325856
9	Congenital stationary night blindness (HP:0007642)	3.42177708
10	Chronic hepatic failure (HP:0100626)	3.35072646
11	Abnormality of the renal medulla (HP:0100957)	3.33083280
12	Inability to walk (HP:0002540)	3.30504358
13	Renal cortical cysts (HP:0000803)	3.20156046
14	Attenuation of retinal blood vessels (HP:0007843)	3.11274262
15	Medial flaring of the eyebrow (HP:0010747)	2.93905031
16	Increased corneal curvature (HP:0100692)	2.75566381
17	Keratoconus (HP:0000563)	2.75566381
18	Cystic liver disease (HP:0006706)	2.66236037
19	Congenital, generalized hypertrichosis (HP:0004540)	2.55114213
20	Acute necrotizing encephalopathy (HP:0006965)	2.55040859
21	Progressive macrocephaly (HP:0004481)	2.52107500
22	Progressive inability to walk (HP:0002505)	2.51200276
23	Sclerocornea (HP:0000647)	2.50049801
24	Gait imbalance (HP:0002141)	2.49781821
25	Abnormal rod and cone electroretinograms (HP:0008323)	2.45521332
26	Cerebellar dysplasia (HP:0007033)	2.43811414
27	3-Methylglutaconic aciduria (HP:0003535)	2.43293666
28	Hyperventilation (HP:0002883)	2.39557811
29	Abolished electroretinogram (ERG) (HP:0000550)	2.36256077
30	Optic disc pallor (HP:0000543)	2.34647264
31	Congenital primary aphakia (HP:0007707)	2.33065794
32	Hemiparesis (HP:0001269)	2.31073463
33	Pendular nystagmus (HP:0012043)	2.27958809
34	Nephrogenic diabetes insipidus (HP:0009806)	2.26690437
35	Abnormal drinking behavior (HP:0030082)	2.24646932
36	Polydipsia (HP:0001959)	2.24646932
37	Delayed CNS myelination (HP:0002188)	2.22907060
38	Stomach cancer (HP:0012126)	2.20680173
39	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.20265161
40	Retinal dysplasia (HP:0007973)	2.17903864
41	Mitochondrial inheritance (HP:0001427)	2.16945055
42	Broad-based gait (HP:0002136)	2.16813783
43	Hypothermia (HP:0002045)	2.16199699
44	Progressive cerebellar ataxia (HP:0002073)	2.14447884
45	Decreased circulating renin level (HP:0003351)	2.13813156
46	Abnormal mitochondria in muscle tissue (HP:0008316)	2.13299030
47	Anencephaly (HP:0002323)	2.11611710
48	Congenital hepatic fibrosis (HP:0002612)	2.09585608
49	Increased CSF lactate (HP:0002490)	2.08710987
50	Limb dystonia (HP:0002451)	2.08320893
51	Lissencephaly (HP:0001339)	2.08206324
52	Hypoproteinemia (HP:0003075)	2.08048073
53	Methylmalonic acidemia (HP:0002912)	2.03321184
54	Calf muscle hypertrophy (HP:0008981)	2.01963066
55	Absent/shortened dynein arms (HP:0200106)	2.01027676
56	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.01027676
57	Focal seizures (HP:0007359)	1.99399350
58	Large for gestational age (HP:0001520)	1.98533695
59	Acute encephalopathy (HP:0006846)	1.97201237
60	Tubular atrophy (HP:0000092)	1.96010699
61	Abnormal biliary tract physiology (HP:0012439)	1.95079618
62	Bile duct proliferation (HP:0001408)	1.95079618
63	Genital tract atresia (HP:0001827)	1.94948732
64	Male pseudohermaphroditism (HP:0000037)	1.93356981
65	Furrowed tongue (HP:0000221)	1.93356120
66	Methylmalonic aciduria (HP:0012120)	1.93165096
67	Concave nail (HP:0001598)	1.92780892
68	Pachygyria (HP:0001302)	1.91808701
69	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.91741718
70	Aplasia/hypoplasia of the uterus (HP:0008684)	1.91520545
71	Absent speech (HP:0001344)	1.91273371
72	Decreased central vision (HP:0007663)	1.91158477
73	Polyuria (HP:0000103)	1.89957597
74	Vaginal atresia (HP:0000148)	1.89183416
75	Focal motor seizures (HP:0011153)	1.89150446
76	Abnormal respiratory epithelium morphology (HP:0012253)	1.88094594
77	Abnormal respiratory motile cilium morphology (HP:0005938)	1.88094594
78	Clumsiness (HP:0002312)	1.87265410
79	Muscle hypertrophy of the lower extremities (HP:0008968)	1.86276823
80	Anterior segment dysgenesis (HP:0007700)	1.84285066
81	Gaze-evoked nystagmus (HP:0000640)	1.83210911
82	Occipital encephalocele (HP:0002085)	1.83055381
83	Abnormality of macular pigmentation (HP:0008002)	1.82681603
84	Febrile seizures (HP:0002373)	1.82236074
85	Facial diplegia (HP:0001349)	1.82206218
86	Hypoplasia of the uterus (HP:0000013)	1.82122270
87	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.81775360
88	Severe muscular hypotonia (HP:0006829)	1.81285665
89	Hypsarrhythmia (HP:0002521)	1.79053785
90	Reduced antithrombin III activity (HP:0001976)	1.78563576
91	Polyphagia (HP:0002591)	1.78215452
92	Ketoacidosis (HP:0001993)	1.78133117
93	Intestinal atresia (HP:0011100)	1.77834680
94	Ketosis (HP:0001946)	1.77553998
95	Hypoalbuminemia (HP:0003073)	1.76860348
96	Abnormal albumin level (HP:0012116)	1.76860348
97	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.76222498
98	Protruding tongue (HP:0010808)	1.75497654
99	Optic nerve hypoplasia (HP:0000609)	1.75124924
100	EEG with generalized epileptiform discharges (HP:0011198)	1.72812203

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	4.70122830
2	FRK	4.08634512
3	INSRR	3.17809849
4	MAP4K2	2.93242247
5	ADRBK2	2.72784331
6	TIE1	2.66728534
7	ZAK	2.53784559
8	WNK3	2.29205999
9	BMPR1B	2.22994586
10	NUAK1	2.12563392
11	MARK1	2.05469040
12	TLK1	1.92152281
13	MAPK13	1.81365416
14	GRK1	1.76836568
15	PHKG2	1.71705732
16	PHKG1	1.71705732
17	OBSCN	1.71449275
18	TXK	1.63494405
19	ITK	1.44693399
20	PTK2B	1.41673594
21	WNK4	1.37907305
22	DYRK2	1.37058827
23	MAPKAPK3	1.32641262
24	CASK	1.28760009
25	MUSK	1.28637451
26	PAK3	1.27629569
27	PNCK	1.27356489
28	MAPK15	1.25598542
29	MAP3K4	1.24143607
30	STK39	1.17880827
31	VRK1	1.12141303
32	TAOK3	1.10623089
33	PRKCE	1.08025167
34	CSNK1G2	1.07074197
35	MARK3	1.06702626
36	MAP2K7	1.06017248
37	OXSR1	1.01072771
38	CSNK1A1L	1.00595776
39	CSNK1G1	0.99891776
40	ADRBK1	0.98931524
41	TNIK	0.98556394
42	RPS6KA5	0.98204639
43	DAPK2	0.97926852
44	BCKDK	0.96401557
45	ACVR1B	0.94565514
46	MYLK	0.94508958
47	CSNK1G3	0.92056495
48	PRKCG	0.90726952
49	LATS1	0.85868757
50	MAPKAPK5	0.85366534
51	STK38L	0.85141064
52	TSSK6	0.84737862
53	GRK5	0.82930817
54	TEC	0.81250668
55	PLK2	0.73656484
56	PKN1	0.72943109
57	NME1	0.71938014
58	PRKCQ	0.70351686
59	CAMKK2	0.70039072
60	TGFBR1	0.66181198
61	FER	0.63912643
62	MAP3K12	0.63533053
63	NLK	0.61317682
64	EPHA3	0.59079937
65	BCR	0.57457458
66	CCNB1	0.56465650
67	BRSK2	0.55829050
68	EIF2AK3	0.55576874
69	CAMK2A	0.55121474
70	CDK3	0.55092948
71	NTRK2	0.53497230
72	CSNK1A1	0.52259951
73	PRKACA	0.51055348
74	EPHB2	0.50763146
75	GRK7	0.50120395
76	PRKG1	0.49066574
77	PLK3	0.48641622
78	GSK3A	0.46947975
79	PIK3CA	0.46418912
80	NTRK3	0.45823108
81	SGK223	0.45659440
82	SGK494	0.45659440
83	KDR	0.44828582
84	ERBB3	0.44739155
85	MAP2K6	0.43948857
86	PRKCZ	0.43657528
87	CSNK1D	0.42398950
88	PRKAA1	0.42085877
89	SGK2	0.42066042
90	FGFR2	0.40594398
91	IGF1R	0.39266163
92	CHEK2	0.38245534
93	IRAK1	0.38231316
94	IKBKB	0.38017301
95	TRIM28	0.37917695
96	CAMK2D	0.37872716
97	MAP2K2	0.37778098
98	PRKAA2	0.36474488
99	MAPK7	0.36387873
100	CHUK	0.35760116

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.08754142
2	Nitrogen metabolism_Homo sapiens_hsa00910	2.67329538
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.51534140
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.36781990
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.33393254
6	Butanoate metabolism_Homo sapiens_hsa00650	2.28939354
7	Nicotine addiction_Homo sapiens_hsa05033	2.28672842
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.24005240
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.22694175
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.14879822
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.10808516
12	RNA polymerase_Homo sapiens_hsa03020	2.02539014
13	Parkinsons disease_Homo sapiens_hsa05012	1.99278916
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.89832129
15	Protein export_Homo sapiens_hsa03060	1.89576193
16	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.80814122
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.77447432
18	Olfactory transduction_Homo sapiens_hsa04740	1.75227319
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.67538395
20	Taste transduction_Homo sapiens_hsa04742	1.61710248
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.60675032
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.58530578
23	Propanoate metabolism_Homo sapiens_hsa00640	1.55266471
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.53953170
25	Morphine addiction_Homo sapiens_hsa05032	1.49980947
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.46255795
27	Basal transcription factors_Homo sapiens_hsa03022	1.43686473
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.35452547
29	GABAergic synapse_Homo sapiens_hsa04727	1.30696829
30	Alzheimers disease_Homo sapiens_hsa05010	1.29302633
31	Regulation of autophagy_Homo sapiens_hsa04140	1.22920434
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.18683032
33	beta-Alanine metabolism_Homo sapiens_hsa00410	1.18631459
34	Peroxisome_Homo sapiens_hsa04146	1.16746018
35	Chemical carcinogenesis_Homo sapiens_hsa05204	1.16534919
36	Circadian entrainment_Homo sapiens_hsa04713	1.15977776
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.14685892
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.10876566
39	Circadian rhythm_Homo sapiens_hsa04710	1.09959225
40	Huntingtons disease_Homo sapiens_hsa05016	1.07528617
41	Caffeine metabolism_Homo sapiens_hsa00232	1.07376798
42	RNA degradation_Homo sapiens_hsa03018	1.07316696
43	Graft-versus-host disease_Homo sapiens_hsa05332	1.06035703
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.03169755
45	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.01645140
46	Salivary secretion_Homo sapiens_hsa04970	0.99108606
47	Glutamatergic synapse_Homo sapiens_hsa04724	0.98009489
48	Insulin secretion_Homo sapiens_hsa04911	0.96561956
49	Fanconi anemia pathway_Homo sapiens_hsa03460	0.95648278
50	ABC transporters_Homo sapiens_hsa02010	0.90985822
51	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.90619422
52	Renin secretion_Homo sapiens_hsa04924	0.88467833
53	Purine metabolism_Homo sapiens_hsa00230	0.88271254
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.88100078
55	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.86976970
56	Type I diabetes mellitus_Homo sapiens_hsa04940	0.84297828
57	Retinol metabolism_Homo sapiens_hsa00830	0.83454806
58	Serotonergic synapse_Homo sapiens_hsa04726	0.83400238
59	Mineral absorption_Homo sapiens_hsa04978	0.82843646
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.81874069
61	Sulfur metabolism_Homo sapiens_hsa00920	0.81704969
62	Homologous recombination_Homo sapiens_hsa03440	0.79829711
63	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.79437705
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.78353955
65	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.73165436
66	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.73091766
67	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.72489560
68	Pyrimidine metabolism_Homo sapiens_hsa00240	0.72058442
69	Collecting duct acid secretion_Homo sapiens_hsa04966	0.71646344
70	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.71287406
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70978005
72	Calcium signaling pathway_Homo sapiens_hsa04020	0.67746891
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67404869
74	Dopaminergic synapse_Homo sapiens_hsa04728	0.62763620
75	Cocaine addiction_Homo sapiens_hsa05030	0.61553757
76	Amphetamine addiction_Homo sapiens_hsa05031	0.60001742
77	Proteasome_Homo sapiens_hsa03050	0.58891791
78	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.57854443
79	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.57190801
80	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.53154068
81	Metabolic pathways_Homo sapiens_hsa01100	0.52912953
82	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.52235791
83	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.49018542
84	Asthma_Homo sapiens_hsa05310	0.48828115
85	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48353253
86	Fat digestion and absorption_Homo sapiens_hsa04975	0.48106209
87	Histidine metabolism_Homo sapiens_hsa00340	0.44594255
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.44296665
89	cAMP signaling pathway_Homo sapiens_hsa04024	0.43077357
90	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.41641447
91	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.38791229
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38029289
93	Allograft rejection_Homo sapiens_hsa05330	0.37764737
94	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.37541427
95	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.37088860
96	Arginine and proline metabolism_Homo sapiens_hsa00330	0.36519458
97	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.35700407
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.34778775
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.34671718
100	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.32682156

LINC00961

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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