

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.90865568 |
| 2 | ATP synthesis coupled proton transport (GO:0015986) | 5.84495926 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.84495926 |
| 4 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.47437925 |
| 5 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.14777219 |
| 6 | respiratory electron transport chain (GO:0022904) | 5.12868424 |
| 7 | electron transport chain (GO:0022900) | 5.02205264 |
| 8 | proteasome assembly (GO:0043248) | 4.82413642 |
| 9 | protein neddylation (GO:0045116) | 4.70195905 |
| 10 | protein complex biogenesis (GO:0070271) | 4.60779328 |
| 11 | oxidative phosphorylation (GO:0006119) | 4.42648695 |
| 12 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.39339768 |
| 13 | respiratory chain complex IV assembly (GO:0008535) | 4.17568951 |
| 14 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.12168426 |
| 15 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.12168426 |
| 16 | NADH dehydrogenase complex assembly (GO:0010257) | 4.12168426 |
| 17 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.06887842 |
| 18 | chaperone-mediated protein transport (GO:0072321) | 4.01806303 |
| 19 | cytochrome complex assembly (GO:0017004) | 3.90913848 |
| 20 | inner mitochondrial membrane organization (GO:0007007) | 3.89192055 |
| 21 | regulation of mitochondrial translation (GO:0070129) | 3.86171876 |
| 22 | rRNA modification (GO:0000154) | 3.83526357 |
| 23 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.77233151 |
| 24 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.76228364 |
| 25 | negative regulation of ligase activity (GO:0051352) | 3.70881356 |
| 26 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.70881356 |
| 27 | ATP biosynthetic process (GO:0006754) | 3.52405191 |
| 28 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.49376886 |
| 29 | rRNA methylation (GO:0031167) | 3.47675382 |
| 30 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.47399227 |
| 31 | termination of RNA polymerase III transcription (GO:0006386) | 3.47399227 |
| 32 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.46223777 |
| 33 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.46082735 |
| 34 | purine nucleobase biosynthetic process (GO:0009113) | 3.45779499 |
| 35 | cullin deneddylation (GO:0010388) | 3.45688224 |
| 36 | ribosomal small subunit assembly (GO:0000028) | 3.44973914 |
| 37 | establishment of integrated proviral latency (GO:0075713) | 3.43141283 |
| 38 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.39129098 |
| 39 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.37820267 |
| 40 | protein targeting to mitochondrion (GO:0006626) | 3.36136923 |
| 41 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.35320420 |
| 42 | CENP-A containing nucleosome assembly (GO:0034080) | 3.32149639 |
| 43 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.30264926 |
| 44 | IMP biosynthetic process (GO:0006188) | 3.28928713 |
| 45 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.26813969 |
| 46 | positive regulation of ligase activity (GO:0051351) | 3.26103235 |
| 47 | hydrogen ion transmembrane transport (GO:1902600) | 3.25870072 |
| 48 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.23631281 |
| 49 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.23631281 |
| 50 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.23631281 |
| 51 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.22647322 |
| 52 | ribosomal large subunit biogenesis (GO:0042273) | 3.21929211 |
| 53 | chromatin remodeling at centromere (GO:0031055) | 3.20438086 |
| 54 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.19253141 |
| 55 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.19253141 |
| 56 | protein localization to mitochondrion (GO:0070585) | 3.18787881 |
| 57 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 3.18675309 |
| 58 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 3.18675309 |
| 59 | platelet dense granule organization (GO:0060155) | 3.17690819 |
| 60 | establishment of protein localization to mitochondrion (GO:0072655) | 3.17152113 |
| 61 | peptidyl-histidine modification (GO:0018202) | 3.16502171 |
| 62 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.13810004 |
| 63 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.13810004 |
| 64 | protein deneddylation (GO:0000338) | 3.13712728 |
| 65 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.10068007 |
| 66 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.10068007 |
| 67 | ubiquinone metabolic process (GO:0006743) | 3.05813163 |
| 68 | ubiquinone biosynthetic process (GO:0006744) | 3.05803377 |
| 69 | translation (GO:0006412) | 3.03897022 |
| 70 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.03694085 |
| 71 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.02840810 |
| 72 | IMP metabolic process (GO:0046040) | 2.98293725 |
| 73 | 7-methylguanosine mRNA capping (GO:0006370) | 2.96978160 |
| 74 | mitochondrial transport (GO:0006839) | 2.96948818 |
| 75 | intracellular protein transmembrane import (GO:0044743) | 2.95390736 |
| 76 | proton transport (GO:0015992) | 2.94751648 |
| 77 | maturation of 5.8S rRNA (GO:0000460) | 2.94203323 |
| 78 | regulation of ligase activity (GO:0051340) | 2.93458454 |
| 79 | aerobic respiration (GO:0009060) | 2.90933832 |
| 80 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.90753894 |
| 81 | AMP metabolic process (GO:0046033) | 2.90686660 |
| 82 | pseudouridine synthesis (GO:0001522) | 2.90369729 |
| 83 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.90196342 |
| 84 | hydrogen transport (GO:0006818) | 2.89851872 |
| 85 | cotranslational protein targeting to membrane (GO:0006613) | 2.89671521 |
| 86 | pteridine-containing compound biosynthetic process (GO:0042559) | 2.89309123 |
| 87 | nucleobase biosynthetic process (GO:0046112) | 2.88633496 |
| 88 | RNA capping (GO:0036260) | 2.88133170 |
| 89 | 7-methylguanosine RNA capping (GO:0009452) | 2.88133170 |
| 90 | organelle disassembly (GO:1903008) | 2.87083937 |
| 91 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.86709266 |
| 92 | aldehyde catabolic process (GO:0046185) | 2.84308491 |
| 93 | ribosome assembly (GO:0042255) | 2.83752948 |
| 94 | cellular respiration (GO:0045333) | 2.82891206 |
| 95 | protein targeting to ER (GO:0045047) | 2.82550687 |
| 96 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.78101709 |
| 97 | ribonucleoside monophosphate biosynthetic process (GO:0009156) | 2.76009047 |
| 98 | protein localization to endoplasmic reticulum (GO:0070972) | 2.75484897 |
| 99 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.73531595 |
| 100 | DNA double-strand break processing (GO:0000729) | 2.73296283 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.52160238 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.66473864 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.09267977 |
| 4 | ELK1_19687146_ChIP-ChIP_HELA_Human | 3.39336653 |
| 5 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.35043081 |
| 6 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.27305283 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.23695746 |
| 8 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.10056838 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.01752350 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.94978790 |
| 11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.93521915 |
| 12 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.93408866 |
| 13 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.62470732 |
| 14 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.54096554 |
| 15 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.53479135 |
| 16 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.51618588 |
| 17 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.29880904 |
| 18 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.25468529 |
| 19 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.14041622 |
| 20 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.13054939 |
| 21 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.09321838 |
| 22 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.09313473 |
| 23 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.09032781 |
| 24 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.07958719 |
| 25 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.03489607 |
| 26 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.01905973 |
| 27 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.00136227 |
| 28 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.99477945 |
| 29 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.98604684 |
| 30 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.95937531 |
| 31 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.87661262 |
| 32 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.84083678 |
| 33 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.74682711 |
| 34 | EWS_26573619_Chip-Seq_HEK293_Human | 1.70036996 |
| 35 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.69913787 |
| 36 | VDR_22108803_ChIP-Seq_LS180_Human | 1.67279999 |
| 37 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.65378172 |
| 38 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.64994659 |
| 39 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.63951727 |
| 40 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.63477240 |
| 41 | FUS_26573619_Chip-Seq_HEK293_Human | 1.62211525 |
| 42 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.61543255 |
| 43 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.61515649 |
| 44 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.58827194 |
| 45 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.48705939 |
| 46 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.48111488 |
| 47 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.43112978 |
| 48 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.42080480 |
| 49 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.34968145 |
| 50 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.33303733 |
| 51 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.32089744 |
| 52 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.31616341 |
| 53 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.29942651 |
| 54 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.27946468 |
| 55 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.22012741 |
| 56 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.17777229 |
| 57 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.17558979 |
| 58 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.15988612 |
| 59 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.14945812 |
| 60 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.14678950 |
| 61 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.12858596 |
| 62 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.11817859 |
| 63 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.10865051 |
| 64 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.08367971 |
| 65 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.06199918 |
| 66 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.06017932 |
| 67 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.04822026 |
| 68 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.03861840 |
| 69 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.02803617 |
| 70 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.00325972 |
| 71 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.98857904 |
| 72 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.98366276 |
| 73 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.98162978 |
| 74 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.97990800 |
| 75 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.97798080 |
| 76 | P300_19829295_ChIP-Seq_ESCs_Human | 0.97388710 |
| 77 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.95563340 |
| 78 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.94973636 |
| 79 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.94953238 |
| 80 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.94739061 |
| 81 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.94380987 |
| 82 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.94355015 |
| 83 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.94262051 |
| 84 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.93866143 |
| 85 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.92980021 |
| 86 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.92980021 |
| 87 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.92952259 |
| 88 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.92575709 |
| 89 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.91761899 |
| 90 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.90215991 |
| 91 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.89231061 |
| 92 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.86292041 |
| 93 | AR_20517297_ChIP-Seq_VCAP_Human | 0.85156963 |
| 94 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.83007707 |
| 95 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.83007163 |
| 96 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.82939292 |
| 97 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.80569665 |
| 98 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.80195862 |
| 99 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.78273163 |
| 100 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.78166466 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002837_dystrophic_cardiac_calcinosis | 3.56642291 |
| 2 | MP0003806_abnormal_nucleotide_metabolis | 3.52081114 |
| 3 | MP0008058_abnormal_DNA_repair | 3.40969016 |
| 4 | MP0006036_abnormal_mitochondrial_physio | 3.09323361 |
| 5 | MP0003186_abnormal_redox_activity | 2.91661416 |
| 6 | MP0000372_irregular_coat_pigmentation | 2.82149993 |
| 7 | MP0009697_abnormal_copulation | 2.82125604 |
| 8 | MP0004147_increased_porphyrin_level | 2.76056482 |
| 9 | MP0010094_abnormal_chromosome_stability | 2.74538830 |
| 10 | MP0006072_abnormal_retinal_apoptosis | 2.68215116 |
| 11 | MP0003136_yellow_coat_color | 2.64543333 |
| 12 | MP0003718_maternal_effect | 2.38365357 |
| 13 | MP0006035_abnormal_mitochondrial_morpho | 2.34888379 |
| 14 | MP0004957_abnormal_blastocyst_morpholog | 2.34435698 |
| 15 | MP0004215_abnormal_myocardial_fiber | 2.30661570 |
| 16 | MP0008007_abnormal_cellular_replicative | 2.19765535 |
| 17 | MP0001529_abnormal_vocalization | 2.16464313 |
| 18 | MP0004145_abnormal_muscle_electrophysio | 2.15588640 |
| 19 | MP0003786_premature_aging | 2.04356590 |
| 20 | MP0003011_delayed_dark_adaptation | 2.02877112 |
| 21 | MP0002638_abnormal_pupillary_reflex | 1.97706902 |
| 22 | MP0002938_white_spotting | 1.93061305 |
| 23 | MP0008932_abnormal_embryonic_tissue | 1.91697529 |
| 24 | MP0002090_abnormal_vision | 1.87608054 |
| 25 | MP0003693_abnormal_embryo_hatching | 1.83514560 |
| 26 | MP0003111_abnormal_nucleus_morphology | 1.83347933 |
| 27 | MP0003077_abnormal_cell_cycle | 1.80146436 |
| 28 | MP0008877_abnormal_DNA_methylation | 1.79748648 |
| 29 | MP0004084_abnormal_cardiac_muscle | 1.75773368 |
| 30 | MP0005084_abnormal_gallbladder_morpholo | 1.75287402 |
| 31 | MP0005253_abnormal_eye_physiology | 1.69948007 |
| 32 | MP0000749_muscle_degeneration | 1.58861146 |
| 33 | MP0003195_calcinosis | 1.58696613 |
| 34 | MP0005408_hypopigmentation | 1.58283761 |
| 35 | MP0001984_abnormal_olfaction | 1.54346262 |
| 36 | MP0005171_absent_coat_pigmentation | 1.50284501 |
| 37 | MP0005332_abnormal_amino_acid | 1.45343173 |
| 38 | MP0001764_abnormal_homeostasis | 1.44285638 |
| 39 | MP0008995_early_reproductive_senescence | 1.43531217 |
| 40 | MP0006292_abnormal_olfactory_placode | 1.40603257 |
| 41 | MP0005330_cardiomyopathy | 1.39840986 |
| 42 | MP0002095_abnormal_skin_pigmentation | 1.38642251 |
| 43 | MP0004036_abnormal_muscle_relaxation | 1.37818733 |
| 44 | MP0003941_abnormal_skin_development | 1.35355916 |
| 45 | MP0000358_abnormal_cell_content/ | 1.34276560 |
| 46 | MP0010386_abnormal_urinary_bladder | 1.30504775 |
| 47 | MP0003137_abnormal_impulse_conducting | 1.25758298 |
| 48 | MP0009379_abnormal_foot_pigmentation | 1.20385382 |
| 49 | MP0008775_abnormal_heart_ventricle | 1.18193445 |
| 50 | MP0002972_abnormal_cardiac_muscle | 1.16430745 |
| 51 | MP0005551_abnormal_eye_electrophysiolog | 1.14623233 |
| 52 | MP0001293_anophthalmia | 1.11024360 |
| 53 | MP0005379_endocrine/exocrine_gland_phen | 1.09880891 |
| 54 | MP0005174_abnormal_tail_pigmentation | 1.09663188 |
| 55 | MP0002102_abnormal_ear_morphology | 1.08356933 |
| 56 | MP0005620_abnormal_muscle_contractility | 1.04969229 |
| 57 | MP0002210_abnormal_sex_determination | 1.03317739 |
| 58 | MP0003646_muscle_fatigue | 1.02773714 |
| 59 | MP0003950_abnormal_plasma_membrane | 1.02392881 |
| 60 | MP0008789_abnormal_olfactory_epithelium | 1.01298405 |
| 61 | MP0001929_abnormal_gametogenesis | 1.00778649 |
| 62 | MP0002277_abnormal_respiratory_mucosa | 0.99773383 |
| 63 | MP0005410_abnormal_fertilization | 0.99726879 |
| 64 | MP0005646_abnormal_pituitary_gland | 0.97134366 |
| 65 | MP0004142_abnormal_muscle_tone | 0.96487037 |
| 66 | MP0000647_abnormal_sebaceous_gland | 0.91801836 |
| 67 | MP0005636_abnormal_mineral_homeostasis | 0.89606763 |
| 68 | MP0001145_abnormal_male_reproductive | 0.88542007 |
| 69 | MP0000653_abnormal_sex_gland | 0.87864338 |
| 70 | MP0005645_abnormal_hypothalamus_physiol | 0.86646606 |
| 71 | MP0004085_abnormal_heartbeat | 0.84676270 |
| 72 | MP0002139_abnormal_hepatobiliary_system | 0.84033093 |
| 73 | MP0008875_abnormal_xenobiotic_pharmacok | 0.83929392 |
| 74 | MP0000343_altered_response_to | 0.83148963 |
| 75 | MP0005165_increased_susceptibility_to | 0.82321415 |
| 76 | MP0003567_abnormal_fetal_cardiomyocyte | 0.81925503 |
| 77 | MP0004484_altered_response_of | 0.81759909 |
| 78 | MP0002160_abnormal_reproductive_system | 0.77783958 |
| 79 | MP0001661_extended_life_span | 0.77425871 |
| 80 | MP0005075_abnormal_melanosome_morpholog | 0.77307811 |
| 81 | MP0001905_abnormal_dopamine_level | 0.75480080 |
| 82 | MP0002269_muscular_atrophy | 0.75214753 |
| 83 | MP0005391_vision/eye_phenotype | 0.74727618 |
| 84 | MP0005389_reproductive_system_phenotype | 0.74175826 |
| 85 | MP0005385_cardiovascular_system_phenoty | 0.72807596 |
| 86 | MP0001544_abnormal_cardiovascular_syste | 0.72807596 |
| 87 | MP0002163_abnormal_gland_morphology | 0.71483757 |
| 88 | MP0003937_abnormal_limbs/digits/tail_de | 0.70347414 |
| 89 | MP0001324_abnormal_eye_pigmentation | 0.70329124 |
| 90 | MP0005266_abnormal_metabolism | 0.70236955 |
| 91 | MP0000631_abnormal_neuroendocrine_gland | 0.69552047 |
| 92 | MP0006276_abnormal_autonomic_nervous | 0.69366354 |
| 93 | MP0002282_abnormal_trachea_morphology | 0.69258110 |
| 94 | MP0001485_abnormal_pinna_reflex | 0.68312141 |
| 95 | MP0009046_muscle_twitch | 0.65128265 |
| 96 | MP0001727_abnormal_embryo_implantation | 0.64845268 |
| 97 | MP0000516_abnormal_urinary_system | 0.64315593 |
| 98 | MP0005367_renal/urinary_system_phenotyp | 0.64315593 |
| 99 | MP0001697_abnormal_embryo_size | 0.62931372 |
| 100 | MP0001853_heart_inflammation | 0.62576503 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.51956675 |
| 2 | Acute encephalopathy (HP:0006846) | 4.98110066 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.97507819 |
| 4 | Mitochondrial inheritance (HP:0001427) | 4.89418575 |
| 5 | Progressive macrocephaly (HP:0004481) | 4.71298962 |
| 6 | Increased hepatocellular lipid droplets (HP:0006565) | 4.62492237 |
| 7 | Increased CSF lactate (HP:0002490) | 4.56640595 |
| 8 | Lipid accumulation in hepatocytes (HP:0006561) | 4.43898671 |
| 9 | Hepatocellular necrosis (HP:0001404) | 4.14445551 |
| 10 | Renal Fanconi syndrome (HP:0001994) | 4.06868315 |
| 11 | Hepatic necrosis (HP:0002605) | 4.03767599 |
| 12 | Cerebral edema (HP:0002181) | 3.83865002 |
| 13 | Increased intramyocellular lipid droplets (HP:0012240) | 3.57227480 |
| 14 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.41371095 |
| 15 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.41371095 |
| 16 | Type I transferrin isoform profile (HP:0003642) | 3.39260858 |
| 17 | Increased serum pyruvate (HP:0003542) | 3.35423035 |
| 18 | Lactic acidosis (HP:0003128) | 3.23268498 |
| 19 | Increased serum lactate (HP:0002151) | 3.22520659 |
| 20 | 3-Methylglutaconic aciduria (HP:0003535) | 3.21200178 |
| 21 | Respiratory failure (HP:0002878) | 3.14073138 |
| 22 | Abnormality of glycolysis (HP:0004366) | 3.03580243 |
| 23 | Increased muscle lipid content (HP:0009058) | 3.00700941 |
| 24 | Exercise intolerance (HP:0003546) | 2.99240831 |
| 25 | Exertional dyspnea (HP:0002875) | 2.87378618 |
| 26 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.87200322 |
| 27 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.87200322 |
| 28 | Abnormal protein glycosylation (HP:0012346) | 2.87200322 |
| 29 | Abnormal glycosylation (HP:0012345) | 2.87200322 |
| 30 | Methylmalonic acidemia (HP:0002912) | 2.81656228 |
| 31 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.68758046 |
| 32 | Lethargy (HP:0001254) | 2.63949768 |
| 33 | Abnormality of methionine metabolism (HP:0010901) | 2.63753046 |
| 34 | Abnormal number of erythroid precursors (HP:0012131) | 2.60447953 |
| 35 | Leukodystrophy (HP:0002415) | 2.55820379 |
| 36 | Abnormality of the anterior horn cell (HP:0006802) | 2.53098806 |
| 37 | Degeneration of anterior horn cells (HP:0002398) | 2.53098806 |
| 38 | Reduced antithrombin III activity (HP:0001976) | 2.49468323 |
| 39 | Congenital, generalized hypertrichosis (HP:0004540) | 2.48452290 |
| 40 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.48450447 |
| 41 | Exercise-induced muscle cramps (HP:0003710) | 2.48285275 |
| 42 | Palpitations (HP:0001962) | 2.46585431 |
| 43 | Abnormality of renal resorption (HP:0011038) | 2.46506925 |
| 44 | Hypoglycemic coma (HP:0001325) | 2.45932385 |
| 45 | Optic disc pallor (HP:0000543) | 2.45221422 |
| 46 | Methylmalonic aciduria (HP:0012120) | 2.44455437 |
| 47 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.42031292 |
| 48 | Glycosuria (HP:0003076) | 2.38849059 |
| 49 | Abnormality of urine glucose concentration (HP:0011016) | 2.38849059 |
| 50 | Amniotic constriction ring (HP:0009775) | 2.36483338 |
| 51 | Abnormality of placental membranes (HP:0011409) | 2.36483338 |
| 52 | Pancreatic fibrosis (HP:0100732) | 2.33014918 |
| 53 | Respiratory difficulties (HP:0002880) | 2.29931479 |
| 54 | CNS demyelination (HP:0007305) | 2.28323305 |
| 55 | True hermaphroditism (HP:0010459) | 2.26691166 |
| 56 | Pancreatic cysts (HP:0001737) | 2.25010641 |
| 57 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.22946361 |
| 58 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.22195383 |
| 59 | Abnormality of alanine metabolism (HP:0010916) | 2.22195383 |
| 60 | Hyperalaninemia (HP:0003348) | 2.22195383 |
| 61 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.20780279 |
| 62 | Macrocytic anemia (HP:0001972) | 2.18035570 |
| 63 | Medial flaring of the eyebrow (HP:0010747) | 2.17480631 |
| 64 | Generalized aminoaciduria (HP:0002909) | 2.17417582 |
| 65 | Microvesicular hepatic steatosis (HP:0001414) | 2.17174502 |
| 66 | Renal cortical cysts (HP:0000803) | 2.07978188 |
| 67 | Nemaline bodies (HP:0003798) | 2.07637912 |
| 68 | Aplastic anemia (HP:0001915) | 2.03465692 |
| 69 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.01059295 |
| 70 | Dicarboxylic aciduria (HP:0003215) | 2.01059295 |
| 71 | Colon cancer (HP:0003003) | 1.99488345 |
| 72 | Hyperphosphaturia (HP:0003109) | 1.98102026 |
| 73 | Myoglobinuria (HP:0002913) | 1.96465091 |
| 74 | Abnormality of serum amino acid levels (HP:0003112) | 1.93472906 |
| 75 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.92066068 |
| 76 | Hyperglycinemia (HP:0002154) | 1.91768028 |
| 77 | Muscle fiber inclusion bodies (HP:0100299) | 1.89381499 |
| 78 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.88061732 |
| 79 | Hypoplasia of the fovea (HP:0007750) | 1.88061732 |
| 80 | Abnormality of midbrain morphology (HP:0002418) | 1.87554779 |
| 81 | Molar tooth sign on MRI (HP:0002419) | 1.87554779 |
| 82 | Poor head control (HP:0002421) | 1.87542240 |
| 83 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 1.86024686 |
| 84 | X-linked dominant inheritance (HP:0001423) | 1.85334151 |
| 85 | Neuroendocrine neoplasm (HP:0100634) | 1.83040363 |
| 86 | Abnormality of the fovea (HP:0000493) | 1.83013888 |
| 87 | Pancytopenia (HP:0001876) | 1.82577648 |
| 88 | Rhabdomyolysis (HP:0003201) | 1.81560302 |
| 89 | Congenital primary aphakia (HP:0007707) | 1.80813079 |
| 90 | Reticulocytopenia (HP:0001896) | 1.78654611 |
| 91 | Hypoglycemic seizures (HP:0002173) | 1.77328569 |
| 92 | Large for gestational age (HP:0001520) | 1.75925224 |
| 93 | Rimmed vacuoles (HP:0003805) | 1.73280150 |
| 94 | Oral leukoplakia (HP:0002745) | 1.73055405 |
| 95 | Abnormality of the labia minora (HP:0012880) | 1.72385652 |
| 96 | Hyperglycinuria (HP:0003108) | 1.72355736 |
| 97 | Sclerocornea (HP:0000647) | 1.70778783 |
| 98 | Ketoacidosis (HP:0001993) | 1.69956412 |
| 99 | Central scotoma (HP:0000603) | 1.68519485 |
| 100 | Abnormality of vitamin B metabolism (HP:0004340) | 1.68094243 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 3.78562933 |
| 2 | MST4 | 3.61912684 |
| 3 | BUB1 | 3.34855138 |
| 4 | PBK | 2.99481592 |
| 5 | STK16 | 2.80600188 |
| 6 | ZAK | 2.77167075 |
| 7 | EIF2AK1 | 2.61331526 |
| 8 | NEK1 | 2.58660874 |
| 9 | EIF2AK3 | 2.55262286 |
| 10 | VRK1 | 2.48091045 |
| 11 | PLK3 | 1.93528863 |
| 12 | SRPK1 | 1.91819567 |
| 13 | BCKDK | 1.82194287 |
| 14 | TTK | 1.81957710 |
| 15 | MAP3K12 | 1.78705552 |
| 16 | NUAK1 | 1.72681980 |
| 17 | TSSK6 | 1.71564400 |
| 18 | WEE1 | 1.71377655 |
| 19 | OBSCN | 1.70952124 |
| 20 | BMPR1B | 1.67599058 |
| 21 | NME1 | 1.66299887 |
| 22 | BRSK2 | 1.54459686 |
| 23 | PLK4 | 1.50821250 |
| 24 | PDK2 | 1.42680429 |
| 25 | NME2 | 1.40362408 |
| 26 | CDC7 | 1.38906578 |
| 27 | MUSK | 1.38576107 |
| 28 | CSNK1G3 | 1.36157640 |
| 29 | CSNK1G1 | 1.30305163 |
| 30 | MKNK1 | 1.27256869 |
| 31 | ERBB3 | 1.26134633 |
| 32 | MAP4K2 | 1.24473490 |
| 33 | PLK2 | 1.24371690 |
| 34 | PNCK | 1.23871335 |
| 35 | TAF1 | 1.23304279 |
| 36 | LIMK1 | 1.20683073 |
| 37 | MYLK | 1.18309797 |
| 38 | ADRBK2 | 1.18206746 |
| 39 | CSNK1G2 | 1.12840947 |
| 40 | PINK1 | 1.12502168 |
| 41 | CCNB1 | 1.08810247 |
| 42 | WNK3 | 1.08415974 |
| 43 | FRK | 1.07500722 |
| 44 | TRIM28 | 1.06454956 |
| 45 | PLK1 | 1.00929486 |
| 46 | ACVR1B | 1.00161245 |
| 47 | PHKG2 | 0.98237065 |
| 48 | PHKG1 | 0.98237065 |
| 49 | TLK1 | 0.96541996 |
| 50 | TNIK | 0.96441019 |
| 51 | MKNK2 | 0.95292036 |
| 52 | CSNK1A1L | 0.94632761 |
| 53 | MAP3K4 | 0.88789482 |
| 54 | GRK1 | 0.83139363 |
| 55 | MAPKAPK3 | 0.81811914 |
| 56 | INSRR | 0.75212089 |
| 57 | MAP2K7 | 0.72622348 |
| 58 | TXK | 0.72467258 |
| 59 | AURKB | 0.70605072 |
| 60 | STK39 | 0.66769656 |
| 61 | CHEK2 | 0.65173997 |
| 62 | EIF2AK2 | 0.64824656 |
| 63 | WNK4 | 0.63519849 |
| 64 | BMPR2 | 0.61827478 |
| 65 | ATR | 0.59527398 |
| 66 | BRSK1 | 0.57857443 |
| 67 | CDK3 | 0.57646368 |
| 68 | CSNK2A2 | 0.57642363 |
| 69 | CSNK2A1 | 0.56553761 |
| 70 | BCR | 0.55643559 |
| 71 | MAPKAPK5 | 0.54521622 |
| 72 | STK38L | 0.53351671 |
| 73 | PRKCE | 0.52712364 |
| 74 | CAMK2D | 0.52442157 |
| 75 | PIK3CG | 0.50961772 |
| 76 | STK3 | 0.48920828 |
| 77 | PIM2 | 0.47868246 |
| 78 | NEK9 | 0.44224978 |
| 79 | STK4 | 0.44056987 |
| 80 | RPS6KA4 | 0.43536514 |
| 81 | TEC | 0.42265105 |
| 82 | GRK7 | 0.41855132 |
| 83 | ERBB4 | 0.41800023 |
| 84 | DAPK1 | 0.41680848 |
| 85 | RPS6KA5 | 0.41445006 |
| 86 | DYRK3 | 0.40938899 |
| 87 | ATM | 0.40640430 |
| 88 | AURKA | 0.40280719 |
| 89 | DAPK3 | 0.39589198 |
| 90 | CSNK1A1 | 0.39545933 |
| 91 | SCYL2 | 0.39366845 |
| 92 | OXSR1 | 0.39169432 |
| 93 | KDR | 0.38449264 |
| 94 | TAOK3 | 0.38033089 |
| 95 | CLK1 | 0.37173212 |
| 96 | PASK | 0.35585956 |
| 97 | CDK8 | 0.35376494 |
| 98 | TGFBR1 | 0.31683021 |
| 99 | CAMK2G | 0.30051213 |
| 100 | CAMK2A | 0.29002921 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.11934628 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 3.92355859 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 3.56382949 |
| 4 | Protein export_Homo sapiens_hsa03060 | 3.30234917 |
| 5 | Ribosome_Homo sapiens_hsa03010 | 2.87525306 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 2.51541203 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 2.43414545 |
| 8 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.42773177 |
| 9 | Alzheimers disease_Homo sapiens_hsa05010 | 2.39583608 |
| 10 | Huntingtons disease_Homo sapiens_hsa05016 | 2.38385120 |
| 11 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.23531131 |
| 12 | Homologous recombination_Homo sapiens_hsa03440 | 2.09223431 |
| 13 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.04252115 |
| 14 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.00949878 |
| 15 | DNA replication_Homo sapiens_hsa03030 | 1.95747640 |
| 16 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.87453214 |
| 17 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.85279032 |
| 18 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.84153578 |
| 19 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.81123260 |
| 20 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.78806194 |
| 21 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.70185948 |
| 22 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.67458866 |
| 23 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.67167185 |
| 24 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.65922818 |
| 25 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.65911669 |
| 26 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.61413504 |
| 27 | RNA degradation_Homo sapiens_hsa03018 | 1.49092120 |
| 28 | Spliceosome_Homo sapiens_hsa03040 | 1.46357226 |
| 29 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.43690902 |
| 30 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.43044681 |
| 31 | Basal transcription factors_Homo sapiens_hsa03022 | 1.42365620 |
| 32 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.39828668 |
| 33 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.36954172 |
| 34 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.36844567 |
| 35 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.36613677 |
| 36 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.31735997 |
| 37 | RNA transport_Homo sapiens_hsa03013 | 1.31725677 |
| 38 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.27073261 |
| 39 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.26165576 |
| 40 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.25669907 |
| 41 | Purine metabolism_Homo sapiens_hsa00230 | 1.20313407 |
| 42 | Base excision repair_Homo sapiens_hsa03410 | 1.13734489 |
| 43 | Peroxisome_Homo sapiens_hsa04146 | 1.13142225 |
| 44 | Carbon metabolism_Homo sapiens_hsa01200 | 1.08967703 |
| 45 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.03678776 |
| 46 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.01081934 |
| 47 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.98097185 |
| 48 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.94816942 |
| 49 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.90291591 |
| 50 | Metabolic pathways_Homo sapiens_hsa01100 | 0.90129592 |
| 51 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.88951925 |
| 52 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.85759356 |
| 53 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.84838345 |
| 54 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.84093016 |
| 55 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.82232989 |
| 56 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.79273613 |
| 57 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.78824249 |
| 58 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.74930700 |
| 59 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.71602526 |
| 60 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.68688521 |
| 61 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.66411003 |
| 62 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.66113582 |
| 63 | Cell cycle_Homo sapiens_hsa04110 | 0.65668265 |
| 64 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.65278097 |
| 65 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.63681152 |
| 66 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.60358358 |
| 67 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.57799757 |
| 68 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.57379347 |
| 69 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.56888208 |
| 70 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.54458977 |
| 71 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.54385411 |
| 72 | Sulfur relay system_Homo sapiens_hsa04122 | 0.51925118 |
| 73 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.51126461 |
| 74 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.45859305 |
| 75 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.44429273 |
| 76 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.44144743 |
| 77 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.41525478 |
| 78 | Phototransduction_Homo sapiens_hsa04744 | 0.39449732 |
| 79 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.36792307 |
| 80 | Retinol metabolism_Homo sapiens_hsa00830 | 0.36160542 |
| 81 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.35750201 |
| 82 | Circadian rhythm_Homo sapiens_hsa04710 | 0.35650358 |
| 83 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.30321576 |
| 84 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.30201041 |
| 85 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.29548776 |
| 86 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.28825443 |
| 87 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.27451760 |
| 88 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.27341702 |
| 89 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.27055837 |
| 90 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.26776831 |
| 91 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.25948702 |
| 92 | Mineral absorption_Homo sapiens_hsa04978 | 0.25453711 |
| 93 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.22993401 |
| 94 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.22392194 |
| 95 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.19935694 |
| 96 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.19003216 |
| 97 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.16203448 |
| 98 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.14608828 |
| 99 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.14151601 |
| 100 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.13374636 |

