LINC00998

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.90865568
2ATP synthesis coupled proton transport (GO:0015986)5.84495926
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.84495926
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.47437925
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.14777219
6respiratory electron transport chain (GO:0022904)5.12868424
7electron transport chain (GO:0022900)5.02205264
8proteasome assembly (GO:0043248)4.82413642
9protein neddylation (GO:0045116)4.70195905
10protein complex biogenesis (GO:0070271)4.60779328
11oxidative phosphorylation (GO:0006119)4.42648695
12mitochondrial respiratory chain complex assembly (GO:0033108)4.39339768
13respiratory chain complex IV assembly (GO:0008535)4.17568951
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.12168426
15mitochondrial respiratory chain complex I assembly (GO:0032981)4.12168426
16NADH dehydrogenase complex assembly (GO:0010257)4.12168426
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.06887842
18chaperone-mediated protein transport (GO:0072321)4.01806303
19cytochrome complex assembly (GO:0017004)3.90913848
20inner mitochondrial membrane organization (GO:0007007)3.89192055
21regulation of mitochondrial translation (GO:0070129)3.86171876
22rRNA modification (GO:0000154)3.83526357
23regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.77233151
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.76228364
25negative regulation of ligase activity (GO:0051352)3.70881356
26negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.70881356
27ATP biosynthetic process (GO:0006754)3.52405191
28anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.49376886
29rRNA methylation (GO:0031167)3.47675382
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.47399227
31termination of RNA polymerase III transcription (GO:0006386)3.47399227
32nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46223777
33regulation of cellular amino acid metabolic process (GO:0006521)3.46082735
34purine nucleobase biosynthetic process (GO:0009113)3.45779499
35cullin deneddylation (GO:0010388)3.45688224
36ribosomal small subunit assembly (GO:0000028)3.44973914
37establishment of integrated proviral latency (GO:0075713)3.43141283
38positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.39129098
39exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37820267
40protein targeting to mitochondrion (GO:0006626)3.36136923
41water-soluble vitamin biosynthetic process (GO:0042364)3.35320420
42CENP-A containing nucleosome assembly (GO:0034080)3.32149639
43purine nucleoside triphosphate biosynthetic process (GO:0009145)3.30264926
44IMP biosynthetic process (GO:0006188)3.28928713
45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26813969
46positive regulation of ligase activity (GO:0051351)3.26103235
47hydrogen ion transmembrane transport (GO:1902600)3.25870072
48signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.23631281
49signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.23631281
50signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.23631281
51purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.22647322
52ribosomal large subunit biogenesis (GO:0042273)3.21929211
53chromatin remodeling at centromere (GO:0031055)3.20438086
54signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.19253141
55intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.19253141
56protein localization to mitochondrion (GO:0070585)3.18787881
57purine nucleoside monophosphate biosynthetic process (GO:0009127)3.18675309
58purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.18675309
59platelet dense granule organization (GO:0060155)3.17690819
60establishment of protein localization to mitochondrion (GO:0072655)3.17152113
61peptidyl-histidine modification (GO:0018202)3.16502171
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.13810004
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.13810004
64protein deneddylation (GO:0000338)3.13712728
65signal transduction involved in DNA damage checkpoint (GO:0072422)3.10068007
66signal transduction involved in DNA integrity checkpoint (GO:0072401)3.10068007
67ubiquinone metabolic process (GO:0006743)3.05813163
68ubiquinone biosynthetic process (GO:0006744)3.05803377
69translation (GO:0006412)3.03897022
70signal transduction involved in cell cycle checkpoint (GO:0072395)3.03694085
71regulation of ubiquitin-protein transferase activity (GO:0051438)3.02840810
72IMP metabolic process (GO:0046040)2.98293725
737-methylguanosine mRNA capping (GO:0006370)2.96978160
74mitochondrial transport (GO:0006839)2.96948818
75intracellular protein transmembrane import (GO:0044743)2.95390736
76proton transport (GO:0015992)2.94751648
77maturation of 5.8S rRNA (GO:0000460)2.94203323
78regulation of ligase activity (GO:0051340)2.93458454
79aerobic respiration (GO:0009060)2.90933832
80SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.90753894
81AMP metabolic process (GO:0046033)2.90686660
82pseudouridine synthesis (GO:0001522)2.90369729
83L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.90196342
84hydrogen transport (GO:0006818)2.89851872
85cotranslational protein targeting to membrane (GO:0006613)2.89671521
86pteridine-containing compound biosynthetic process (GO:0042559)2.89309123
87nucleobase biosynthetic process (GO:0046112)2.88633496
88RNA capping (GO:0036260)2.88133170
897-methylguanosine RNA capping (GO:0009452)2.88133170
90organelle disassembly (GO:1903008)2.87083937
91ribonucleoside triphosphate biosynthetic process (GO:0009201)2.86709266
92aldehyde catabolic process (GO:0046185)2.84308491
93ribosome assembly (GO:0042255)2.83752948
94cellular respiration (GO:0045333)2.82891206
95protein targeting to ER (GO:0045047)2.82550687
96establishment of protein localization to endoplasmic reticulum (GO:0072599)2.78101709
97ribonucleoside monophosphate biosynthetic process (GO:0009156)2.76009047
98protein localization to endoplasmic reticulum (GO:0070972)2.75484897
99nucleoside triphosphate biosynthetic process (GO:0009142)2.73531595
100DNA double-strand break processing (GO:0000729)2.73296283

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.52160238
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.66473864
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.09267977
4ELK1_19687146_ChIP-ChIP_HELA_Human3.39336653
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.35043081
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.27305283
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.23695746
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.10056838
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01752350
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.94978790
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.93521915
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.93408866
13VDR_23849224_ChIP-Seq_CD4+_Human2.62470732
14E2F7_22180533_ChIP-Seq_HELA_Human2.54096554
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.53479135
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.51618588
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.29880904
18FOXP3_21729870_ChIP-Seq_TREG_Human2.25468529
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.14041622
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13054939
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09321838
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.09313473
23DCP1A_22483619_ChIP-Seq_HELA_Human2.09032781
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07958719
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03489607
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01905973
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00136227
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.99477945
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.98604684
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.95937531
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87661262
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.84083678
33TTF2_22483619_ChIP-Seq_HELA_Human1.74682711
34EWS_26573619_Chip-Seq_HEK293_Human1.70036996
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69913787
36VDR_22108803_ChIP-Seq_LS180_Human1.67279999
37MYC_18940864_ChIP-ChIP_HL60_Human1.65378172
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64994659
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63951727
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.63477240
41FUS_26573619_Chip-Seq_HEK293_Human1.62211525
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61543255
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61515649
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58827194
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.48705939
46GABP_19822575_ChIP-Seq_HepG2_Human1.48111488
47IGF1R_20145208_ChIP-Seq_DFB_Human1.43112978
48XRN2_22483619_ChIP-Seq_HELA_Human1.42080480
49HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.34968145
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.33303733
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32089744
52ZNF274_21170338_ChIP-Seq_K562_Hela1.31616341
53ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.29942651
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27946468
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22012741
56AR_21909140_ChIP-Seq_LNCAP_Human1.17777229
57CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.17558979
58HTT_18923047_ChIP-ChIP_STHdh_Human1.15988612
59TAF15_26573619_Chip-Seq_HEK293_Human1.14945812
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14678950
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12858596
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11817859
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10865051
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08367971
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.06199918
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06017932
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04822026
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.03861840
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02803617
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00325972
71SALL1_21062744_ChIP-ChIP_HESCs_Human0.98857904
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98366276
73KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98162978
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97990800
75SOX17_20123909_ChIP-Seq_XEN_Mouse0.97798080
76P300_19829295_ChIP-Seq_ESCs_Human0.97388710
77TFEB_21752829_ChIP-Seq_HELA_Human0.95563340
78ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94973636
79ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94953238
80ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94739061
81SALL4_22934838_ChIP-ChIP_CD34+_Human0.94380987
82E2F1_21310950_ChIP-Seq_MCF-7_Human0.94355015
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94262051
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93866143
85NANOG_19829295_ChIP-Seq_ESCs_Human0.92980021
86SOX2_19829295_ChIP-Seq_ESCs_Human0.92980021
87EZH2_27294783_Chip-Seq_NPCs_Mouse0.92952259
88POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92575709
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91761899
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90215991
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89231061
92SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86292041
93AR_20517297_ChIP-Seq_VCAP_Human0.85156963
94KDM5A_27292631_Chip-Seq_BREAST_Human0.83007707
95TP53_22573176_ChIP-Seq_HFKS_Human0.83007163
96SOX2_16153702_ChIP-ChIP_HESCs_Human0.82939292
97NFE2_27457419_Chip-Seq_LIVER_Mouse0.80569665
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80195862
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.78273163
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78166466

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.56642291
2MP0003806_abnormal_nucleotide_metabolis3.52081114
3MP0008058_abnormal_DNA_repair3.40969016
4MP0006036_abnormal_mitochondrial_physio3.09323361
5MP0003186_abnormal_redox_activity2.91661416
6MP0000372_irregular_coat_pigmentation2.82149993
7MP0009697_abnormal_copulation2.82125604
8MP0004147_increased_porphyrin_level2.76056482
9MP0010094_abnormal_chromosome_stability2.74538830
10MP0006072_abnormal_retinal_apoptosis2.68215116
11MP0003136_yellow_coat_color2.64543333
12MP0003718_maternal_effect2.38365357
13MP0006035_abnormal_mitochondrial_morpho2.34888379
14MP0004957_abnormal_blastocyst_morpholog2.34435698
15MP0004215_abnormal_myocardial_fiber2.30661570
16MP0008007_abnormal_cellular_replicative2.19765535
17MP0001529_abnormal_vocalization2.16464313
18MP0004145_abnormal_muscle_electrophysio2.15588640
19MP0003786_premature_aging2.04356590
20MP0003011_delayed_dark_adaptation2.02877112
21MP0002638_abnormal_pupillary_reflex1.97706902
22MP0002938_white_spotting1.93061305
23MP0008932_abnormal_embryonic_tissue1.91697529
24MP0002090_abnormal_vision1.87608054
25MP0003693_abnormal_embryo_hatching1.83514560
26MP0003111_abnormal_nucleus_morphology1.83347933
27MP0003077_abnormal_cell_cycle1.80146436
28MP0008877_abnormal_DNA_methylation1.79748648
29MP0004084_abnormal_cardiac_muscle1.75773368
30MP0005084_abnormal_gallbladder_morpholo1.75287402
31MP0005253_abnormal_eye_physiology1.69948007
32MP0000749_muscle_degeneration1.58861146
33MP0003195_calcinosis1.58696613
34MP0005408_hypopigmentation1.58283761
35MP0001984_abnormal_olfaction1.54346262
36MP0005171_absent_coat_pigmentation1.50284501
37MP0005332_abnormal_amino_acid1.45343173
38MP0001764_abnormal_homeostasis1.44285638
39MP0008995_early_reproductive_senescence1.43531217
40MP0006292_abnormal_olfactory_placode1.40603257
41MP0005330_cardiomyopathy1.39840986
42MP0002095_abnormal_skin_pigmentation1.38642251
43MP0004036_abnormal_muscle_relaxation1.37818733
44MP0003941_abnormal_skin_development1.35355916
45MP0000358_abnormal_cell_content/1.34276560
46MP0010386_abnormal_urinary_bladder1.30504775
47MP0003137_abnormal_impulse_conducting1.25758298
48MP0009379_abnormal_foot_pigmentation1.20385382
49MP0008775_abnormal_heart_ventricle1.18193445
50MP0002972_abnormal_cardiac_muscle1.16430745
51MP0005551_abnormal_eye_electrophysiolog1.14623233
52MP0001293_anophthalmia1.11024360
53MP0005379_endocrine/exocrine_gland_phen1.09880891
54MP0005174_abnormal_tail_pigmentation1.09663188
55MP0002102_abnormal_ear_morphology1.08356933
56MP0005620_abnormal_muscle_contractility1.04969229
57MP0002210_abnormal_sex_determination1.03317739
58MP0003646_muscle_fatigue1.02773714
59MP0003950_abnormal_plasma_membrane1.02392881
60MP0008789_abnormal_olfactory_epithelium1.01298405
61MP0001929_abnormal_gametogenesis1.00778649
62MP0002277_abnormal_respiratory_mucosa0.99773383
63MP0005410_abnormal_fertilization0.99726879
64MP0005646_abnormal_pituitary_gland0.97134366
65MP0004142_abnormal_muscle_tone0.96487037
66MP0000647_abnormal_sebaceous_gland0.91801836
67MP0005636_abnormal_mineral_homeostasis0.89606763
68MP0001145_abnormal_male_reproductive0.88542007
69MP0000653_abnormal_sex_gland0.87864338
70MP0005645_abnormal_hypothalamus_physiol0.86646606
71MP0004085_abnormal_heartbeat0.84676270
72MP0002139_abnormal_hepatobiliary_system0.84033093
73MP0008875_abnormal_xenobiotic_pharmacok0.83929392
74MP0000343_altered_response_to0.83148963
75MP0005165_increased_susceptibility_to0.82321415
76MP0003567_abnormal_fetal_cardiomyocyte0.81925503
77MP0004484_altered_response_of0.81759909
78MP0002160_abnormal_reproductive_system0.77783958
79MP0001661_extended_life_span0.77425871
80MP0005075_abnormal_melanosome_morpholog0.77307811
81MP0001905_abnormal_dopamine_level0.75480080
82MP0002269_muscular_atrophy0.75214753
83MP0005391_vision/eye_phenotype0.74727618
84MP0005389_reproductive_system_phenotype0.74175826
85MP0005385_cardiovascular_system_phenoty0.72807596
86MP0001544_abnormal_cardiovascular_syste0.72807596
87MP0002163_abnormal_gland_morphology0.71483757
88MP0003937_abnormal_limbs/digits/tail_de0.70347414
89MP0001324_abnormal_eye_pigmentation0.70329124
90MP0005266_abnormal_metabolism0.70236955
91MP0000631_abnormal_neuroendocrine_gland0.69552047
92MP0006276_abnormal_autonomic_nervous0.69366354
93MP0002282_abnormal_trachea_morphology0.69258110
94MP0001485_abnormal_pinna_reflex0.68312141
95MP0009046_muscle_twitch0.65128265
96MP0001727_abnormal_embryo_implantation0.64845268
97MP0000516_abnormal_urinary_system0.64315593
98MP0005367_renal/urinary_system_phenotyp0.64315593
99MP0001697_abnormal_embryo_size0.62931372
100MP0001853_heart_inflammation0.62576503

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.51956675
2Acute encephalopathy (HP:0006846)4.98110066
3Abnormal mitochondria in muscle tissue (HP:0008316)4.97507819
4Mitochondrial inheritance (HP:0001427)4.89418575
5Progressive macrocephaly (HP:0004481)4.71298962
6Increased hepatocellular lipid droplets (HP:0006565)4.62492237
7Increased CSF lactate (HP:0002490)4.56640595
8Lipid accumulation in hepatocytes (HP:0006561)4.43898671
9Hepatocellular necrosis (HP:0001404)4.14445551
10Renal Fanconi syndrome (HP:0001994)4.06868315
11Hepatic necrosis (HP:0002605)4.03767599
12Cerebral edema (HP:0002181)3.83865002
13Increased intramyocellular lipid droplets (HP:0012240)3.57227480
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.41371095
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.41371095
16Type I transferrin isoform profile (HP:0003642)3.39260858
17Increased serum pyruvate (HP:0003542)3.35423035
18Lactic acidosis (HP:0003128)3.23268498
19Increased serum lactate (HP:0002151)3.22520659
203-Methylglutaconic aciduria (HP:0003535)3.21200178
21Respiratory failure (HP:0002878)3.14073138
22Abnormality of glycolysis (HP:0004366)3.03580243
23Increased muscle lipid content (HP:0009058)3.00700941
24Exercise intolerance (HP:0003546)2.99240831
25Exertional dyspnea (HP:0002875)2.87378618
26Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.87200322
27Abnormal protein N-linked glycosylation (HP:0012347)2.87200322
28Abnormal protein glycosylation (HP:0012346)2.87200322
29Abnormal glycosylation (HP:0012345)2.87200322
30Methylmalonic acidemia (HP:0002912)2.81656228
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.68758046
32Lethargy (HP:0001254)2.63949768
33Abnormality of methionine metabolism (HP:0010901)2.63753046
34Abnormal number of erythroid precursors (HP:0012131)2.60447953
35Leukodystrophy (HP:0002415)2.55820379
36Abnormality of the anterior horn cell (HP:0006802)2.53098806
37Degeneration of anterior horn cells (HP:0002398)2.53098806
38Reduced antithrombin III activity (HP:0001976)2.49468323
39Congenital, generalized hypertrichosis (HP:0004540)2.48452290
40Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.48450447
41Exercise-induced muscle cramps (HP:0003710)2.48285275
42Palpitations (HP:0001962)2.46585431
43Abnormality of renal resorption (HP:0011038)2.46506925
44Hypoglycemic coma (HP:0001325)2.45932385
45Optic disc pallor (HP:0000543)2.45221422
46Methylmalonic aciduria (HP:0012120)2.44455437
47Abnormality of cells of the erythroid lineage (HP:0012130)2.42031292
48Glycosuria (HP:0003076)2.38849059
49Abnormality of urine glucose concentration (HP:0011016)2.38849059
50Amniotic constriction ring (HP:0009775)2.36483338
51Abnormality of placental membranes (HP:0011409)2.36483338
52Pancreatic fibrosis (HP:0100732)2.33014918
53Respiratory difficulties (HP:0002880)2.29931479
54CNS demyelination (HP:0007305)2.28323305
55True hermaphroditism (HP:0010459)2.26691166
56Pancreatic cysts (HP:0001737)2.25010641
57Hyperinsulinemic hypoglycemia (HP:0000825)2.22946361
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22195383
59Abnormality of alanine metabolism (HP:0010916)2.22195383
60Hyperalaninemia (HP:0003348)2.22195383
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20780279
62Macrocytic anemia (HP:0001972)2.18035570
63Medial flaring of the eyebrow (HP:0010747)2.17480631
64Generalized aminoaciduria (HP:0002909)2.17417582
65Microvesicular hepatic steatosis (HP:0001414)2.17174502
66Renal cortical cysts (HP:0000803)2.07978188
67Nemaline bodies (HP:0003798)2.07637912
68Aplastic anemia (HP:0001915)2.03465692
69Abnormality of dicarboxylic acid metabolism (HP:0010995)2.01059295
70Dicarboxylic aciduria (HP:0003215)2.01059295
71Colon cancer (HP:0003003)1.99488345
72Hyperphosphaturia (HP:0003109)1.98102026
73Myoglobinuria (HP:0002913)1.96465091
74Abnormality of serum amino acid levels (HP:0003112)1.93472906
75Pancreatic islet-cell hyperplasia (HP:0004510)1.92066068
76Hyperglycinemia (HP:0002154)1.91768028
77Muscle fiber inclusion bodies (HP:0100299)1.89381499
78Aplasia/Hypoplasia of the fovea (HP:0008060)1.88061732
79Hypoplasia of the fovea (HP:0007750)1.88061732
80Abnormality of midbrain morphology (HP:0002418)1.87554779
81Molar tooth sign on MRI (HP:0002419)1.87554779
82Poor head control (HP:0002421)1.87542240
83Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.86024686
84X-linked dominant inheritance (HP:0001423)1.85334151
85Neuroendocrine neoplasm (HP:0100634)1.83040363
86Abnormality of the fovea (HP:0000493)1.83013888
87Pancytopenia (HP:0001876)1.82577648
88Rhabdomyolysis (HP:0003201)1.81560302
89Congenital primary aphakia (HP:0007707)1.80813079
90Reticulocytopenia (HP:0001896)1.78654611
91Hypoglycemic seizures (HP:0002173)1.77328569
92Large for gestational age (HP:0001520)1.75925224
93Rimmed vacuoles (HP:0003805)1.73280150
94Oral leukoplakia (HP:0002745)1.73055405
95Abnormality of the labia minora (HP:0012880)1.72385652
96Hyperglycinuria (HP:0003108)1.72355736
97Sclerocornea (HP:0000647)1.70778783
98Ketoacidosis (HP:0001993)1.69956412
99Central scotoma (HP:0000603)1.68519485
100Abnormality of vitamin B metabolism (HP:0004340)1.68094243

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.78562933
2MST43.61912684
3BUB13.34855138
4PBK2.99481592
5STK162.80600188
6ZAK2.77167075
7EIF2AK12.61331526
8NEK12.58660874
9EIF2AK32.55262286
10VRK12.48091045
11PLK31.93528863
12SRPK11.91819567
13BCKDK1.82194287
14TTK1.81957710
15MAP3K121.78705552
16NUAK11.72681980
17TSSK61.71564400
18WEE11.71377655
19OBSCN1.70952124
20BMPR1B1.67599058
21NME11.66299887
22BRSK21.54459686
23PLK41.50821250
24PDK21.42680429
25NME21.40362408
26CDC71.38906578
27MUSK1.38576107
28CSNK1G31.36157640
29CSNK1G11.30305163
30MKNK11.27256869
31ERBB31.26134633
32MAP4K21.24473490
33PLK21.24371690
34PNCK1.23871335
35TAF11.23304279
36LIMK11.20683073
37MYLK1.18309797
38ADRBK21.18206746
39CSNK1G21.12840947
40PINK11.12502168
41CCNB11.08810247
42WNK31.08415974
43FRK1.07500722
44TRIM281.06454956
45PLK11.00929486
46ACVR1B1.00161245
47PHKG20.98237065
48PHKG10.98237065
49TLK10.96541996
50TNIK0.96441019
51MKNK20.95292036
52CSNK1A1L0.94632761
53MAP3K40.88789482
54GRK10.83139363
55MAPKAPK30.81811914
56INSRR0.75212089
57MAP2K70.72622348
58TXK0.72467258
59AURKB0.70605072
60STK390.66769656
61CHEK20.65173997
62EIF2AK20.64824656
63WNK40.63519849
64BMPR20.61827478
65ATR0.59527398
66BRSK10.57857443
67CDK30.57646368
68CSNK2A20.57642363
69CSNK2A10.56553761
70BCR0.55643559
71MAPKAPK50.54521622
72STK38L0.53351671
73PRKCE0.52712364
74CAMK2D0.52442157
75PIK3CG0.50961772
76STK30.48920828
77PIM20.47868246
78NEK90.44224978
79STK40.44056987
80RPS6KA40.43536514
81TEC0.42265105
82GRK70.41855132
83ERBB40.41800023
84DAPK10.41680848
85RPS6KA50.41445006
86DYRK30.40938899
87ATM0.40640430
88AURKA0.40280719
89DAPK30.39589198
90CSNK1A10.39545933
91SCYL20.39366845
92OXSR10.39169432
93KDR0.38449264
94TAOK30.38033089
95CLK10.37173212
96PASK0.35585956
97CDK80.35376494
98TGFBR10.31683021
99CAMK2G0.30051213
100CAMK2A0.29002921

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.11934628
2Proteasome_Homo sapiens_hsa030503.92355859
3Parkinsons disease_Homo sapiens_hsa050123.56382949
4Protein export_Homo sapiens_hsa030603.30234917
5Ribosome_Homo sapiens_hsa030102.87525306
6Mismatch repair_Homo sapiens_hsa034302.51541203
7RNA polymerase_Homo sapiens_hsa030202.43414545
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.42773177
9Alzheimers disease_Homo sapiens_hsa050102.39583608
10Huntingtons disease_Homo sapiens_hsa050162.38385120
11Propanoate metabolism_Homo sapiens_hsa006402.23531131
12Homologous recombination_Homo sapiens_hsa034402.09223431
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.04252115
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.00949878
15DNA replication_Homo sapiens_hsa030301.95747640
16Fatty acid elongation_Homo sapiens_hsa000621.87453214
17Nucleotide excision repair_Homo sapiens_hsa034201.85279032
18Cardiac muscle contraction_Homo sapiens_hsa042601.84153578
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.81123260
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78806194
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.70185948
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.67458866
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67167185
24One carbon pool by folate_Homo sapiens_hsa006701.65922818
25Pyruvate metabolism_Homo sapiens_hsa006201.65911669
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61413504
27RNA degradation_Homo sapiens_hsa030181.49092120
28Spliceosome_Homo sapiens_hsa030401.46357226
29Steroid biosynthesis_Homo sapiens_hsa001001.43690902
30Butanoate metabolism_Homo sapiens_hsa006501.43044681
31Basal transcription factors_Homo sapiens_hsa030221.42365620
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39828668
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.36954172
34Fanconi anemia pathway_Homo sapiens_hsa034601.36844567
35Sulfur metabolism_Homo sapiens_hsa009201.36613677
36Pyrimidine metabolism_Homo sapiens_hsa002401.31735997
37RNA transport_Homo sapiens_hsa030131.31725677
38Folate biosynthesis_Homo sapiens_hsa007901.27073261
39Non-homologous end-joining_Homo sapiens_hsa034501.26165576
40Glutathione metabolism_Homo sapiens_hsa004801.25669907
41Purine metabolism_Homo sapiens_hsa002301.20313407
42Base excision repair_Homo sapiens_hsa034101.13734489
43Peroxisome_Homo sapiens_hsa041461.13142225
44Carbon metabolism_Homo sapiens_hsa012001.08967703
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03678776
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01081934
47Selenocompound metabolism_Homo sapiens_hsa004500.98097185
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.94816942
49Fatty acid metabolism_Homo sapiens_hsa012120.90291591
50Metabolic pathways_Homo sapiens_hsa011000.90129592
51Nitrogen metabolism_Homo sapiens_hsa009100.88951925
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85759356
53Tryptophan metabolism_Homo sapiens_hsa003800.84838345
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.84093016
55Fatty acid degradation_Homo sapiens_hsa000710.82232989
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79273613
57Biosynthesis of amino acids_Homo sapiens_hsa012300.78824249
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74930700
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71602526
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68688521
61Vitamin B6 metabolism_Homo sapiens_hsa007500.66411003
62Collecting duct acid secretion_Homo sapiens_hsa049660.66113582
63Cell cycle_Homo sapiens_hsa041100.65668265
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65278097
65N-Glycan biosynthesis_Homo sapiens_hsa005100.63681152
66beta-Alanine metabolism_Homo sapiens_hsa004100.60358358
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57799757
68Arginine and proline metabolism_Homo sapiens_hsa003300.57379347
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56888208
70Pentose phosphate pathway_Homo sapiens_hsa000300.54458977
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54385411
72Sulfur relay system_Homo sapiens_hsa041220.51925118
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51126461
74Caffeine metabolism_Homo sapiens_hsa002320.45859305
75Chemical carcinogenesis_Homo sapiens_hsa052040.44429273
76Oocyte meiosis_Homo sapiens_hsa041140.44144743
77Regulation of autophagy_Homo sapiens_hsa041400.41525478
78Phototransduction_Homo sapiens_hsa047440.39449732
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36792307
80Retinol metabolism_Homo sapiens_hsa008300.36160542
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35750201
82Circadian rhythm_Homo sapiens_hsa047100.35650358
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30321576
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30201041
85p53 signaling pathway_Homo sapiens_hsa041150.29548776
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28825443
87Linoleic acid metabolism_Homo sapiens_hsa005910.27451760
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27341702
89Rheumatoid arthritis_Homo sapiens_hsa053230.27055837
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26776831
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25948702
92Mineral absorption_Homo sapiens_hsa049780.25453711
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22993401
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.22392194
95Tyrosine metabolism_Homo sapiens_hsa003500.19935694
96mRNA surveillance pathway_Homo sapiens_hsa030150.19003216
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.16203448
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14608828
99Arachidonic acid metabolism_Homo sapiens_hsa005900.14151601
100Fructose and mannose metabolism_Homo sapiens_hsa000510.13374636

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