ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.55958984
2	response to pheromone (GO:0019236)	4.51318687
3	regulation of hippo signaling (GO:0035330)	3.82864436
4	sperm motility (GO:0030317)	3.82009414
5	regulation of mesoderm development (GO:2000380)	3.76416655
6	rRNA methylation (GO:0031167)	3.69248078
7	multicellular organism reproduction (GO:0032504)	3.61463207
8	single strand break repair (GO:0000012)	3.55653913
9	epithelial cilium movement (GO:0003351)	3.55496483
10	rRNA modification (GO:0000154)	3.51474340
11	L-fucose metabolic process (GO:0042354)	3.48672881
12	L-fucose catabolic process (GO:0042355)	3.48672881
13	fucose catabolic process (GO:0019317)	3.48672881
14	acrosome reaction (GO:0007340)	3.44125372
15	cellular ketone body metabolic process (GO:0046950)	3.43428842
16	detection of light stimulus involved in sensory perception (GO:0050962)	3.40222958
17	detection of light stimulus involved in visual perception (GO:0050908)	3.40222958
18	negative regulation of telomere maintenance (GO:0032205)	3.33372475
19	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.30620179
20	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.27413178
21	protein polyglutamylation (GO:0018095)	3.20547802
22	regulation of posttranscriptional gene silencing (GO:0060147)	3.20314914
23	regulation of gene silencing by miRNA (GO:0060964)	3.20314914
24	regulation of gene silencing by RNA (GO:0060966)	3.20314914
25	tryptophan catabolic process (GO:0006569)	3.19998950
26	indole-containing compound catabolic process (GO:0042436)	3.19998950
27	indolalkylamine catabolic process (GO:0046218)	3.19998950
28	cilium movement (GO:0003341)	3.14788805
29	kynurenine metabolic process (GO:0070189)	3.13209990
30	axoneme assembly (GO:0035082)	3.10126076
31	cilium or flagellum-dependent cell motility (GO:0001539)	3.08955824
32	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.08219074
33	indolalkylamine metabolic process (GO:0006586)	3.04954739
34	platelet dense granule organization (GO:0060155)	2.97949099
35	DNA deamination (GO:0045006)	2.97428801
36	ketone body metabolic process (GO:1902224)	2.97412523
37	spermatid development (GO:0007286)	2.92857738
38	nonmotile primary cilium assembly (GO:0035058)	2.92096659
39	centriole replication (GO:0007099)	2.91355498
40	water-soluble vitamin biosynthetic process (GO:0042364)	2.91262392
41	cornea development in camera-type eye (GO:0061303)	2.90055048
42	axonemal dynein complex assembly (GO:0070286)	2.89248070
43	nephron tubule morphogenesis (GO:0072078)	2.87364349
44	nephron epithelium morphogenesis (GO:0072088)	2.87364349
45	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.87151601
46	preassembly of GPI anchor in ER membrane (GO:0016254)	2.83177459
47	microtubule depolymerization (GO:0007019)	2.82946227
48	photoreceptor cell maintenance (GO:0045494)	2.82926760
49	somite rostral/caudal axis specification (GO:0032525)	2.81746006
50	regulation of cilium movement (GO:0003352)	2.80898578
51	piRNA metabolic process (GO:0034587)	2.80128971
52	DNA double-strand break processing (GO:0000729)	2.76109955
53	cilium organization (GO:0044782)	2.71596682
54	spinal cord motor neuron differentiation (GO:0021522)	2.70311970
55	male meiosis I (GO:0007141)	2.69927070
56	respiratory chain complex IV assembly (GO:0008535)	2.67389773
57	cilium assembly (GO:0042384)	2.67381808
58	reciprocal DNA recombination (GO:0035825)	2.66577408
59	reciprocal meiotic recombination (GO:0007131)	2.66577408
60	sperm-egg recognition (GO:0035036)	2.66532355
61	cilium morphogenesis (GO:0060271)	2.65149888
62	endoderm formation (GO:0001706)	2.61903347
63	regulation of meiosis I (GO:0060631)	2.61798423
64	rhodopsin mediated signaling pathway (GO:0016056)	2.58222634
65	pseudouridine synthesis (GO:0001522)	2.57515488
66	establishment of protein localization to Golgi (GO:0072600)	2.57040269
67	recombinational repair (GO:0000725)	2.56489229
68	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.56019099
69	replication fork processing (GO:0031297)	2.55707266
70	reflex (GO:0060004)	2.55232479
71	double-strand break repair via homologous recombination (GO:0000724)	2.55037722
72	regulation of telomere maintenance (GO:0032204)	2.54336927
73	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.53105335
74	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.52078136
75	kidney morphogenesis (GO:0060993)	2.50771257
76	male meiosis (GO:0007140)	2.49728364
77	tryptophan metabolic process (GO:0006568)	2.47541003
78	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.47526490
79	protein-cofactor linkage (GO:0018065)	2.46864613
80	sulfation (GO:0051923)	2.46221483
81	retinal cone cell development (GO:0046549)	2.46143053
82	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.45325511
83	DNA methylation involved in gamete generation (GO:0043046)	2.44419681
84	microtubule polymerization or depolymerization (GO:0031109)	2.44182773
85	nephron tubule formation (GO:0072079)	2.44140590
86	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.43781397
87	regulation of translation, ncRNA-mediated (GO:0045974)	2.43781397
88	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.43781397
89	indole-containing compound metabolic process (GO:0042430)	2.42850169
90	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.41065707
91	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.40567825
92	mannosylation (GO:0097502)	2.39566898
93	protein complex biogenesis (GO:0070271)	2.39186968
94	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.38565425
95	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.38565425
96	NADH dehydrogenase complex assembly (GO:0010257)	2.38565425
97	NAD biosynthetic process (GO:0009435)	2.33357167
98	neural tube formation (GO:0001841)	2.32974547
99	cytochrome complex assembly (GO:0017004)	2.32865152
100	peptidyl-histidine modification (GO:0018202)	2.31100592

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.03208316
2	VDR_22108803_ChIP-Seq_LS180_Human	3.50551442
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.09099726
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.81669472
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.72122310
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.40170004
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.37298690
8	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.23851383
9	P300_19829295_ChIP-Seq_ESCs_Human	2.20243401
10	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.17472334
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.16068996
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.11753857
13	FUS_26573619_Chip-Seq_HEK293_Human	2.08844631
14	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.06511346
15	EWS_26573619_Chip-Seq_HEK293_Human	2.05766663
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.05760140
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.00920431
18	TAF15_26573619_Chip-Seq_HEK293_Human	1.89987797
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.87053371
20	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.84760272
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.82994335
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.76011197
23	CBP_20019798_ChIP-Seq_JUKART_Human	1.67305557
24	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.67305557
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.67199972
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.64835738
27	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.62346068
28	AR_25329375_ChIP-Seq_VCAP_Human	1.61168757
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.60665239
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.58198261
31	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.58065937
32	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.58008216
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.55443865
34	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.53419268
35	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53419268
36	STAT3_23295773_ChIP-Seq_U87_Human	1.50151841
37	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.48590232
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.47940487
39	SOX2_19829295_ChIP-Seq_ESCs_Human	1.45111737
40	NANOG_19829295_ChIP-Seq_ESCs_Human	1.45111737
41	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.44750855
42	TCF4_22108803_ChIP-Seq_LS180_Human	1.42921058
43	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.40619981
44	AR_21572438_ChIP-Seq_LNCaP_Human	1.39900512
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.38846464
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.38318147
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.38170558
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.37524838
49	TCF4_23295773_ChIP-Seq_U87_Human	1.37413150
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36723724
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36723724
52	BCAT_22108803_ChIP-Seq_LS180_Human	1.34479146
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33141347
54	RUNX2_22187159_ChIP-Seq_PCA_Human	1.33127699
55	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32609259
56	HOXB7_26014856_ChIP-Seq_BT474_Human	1.32252158
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.29329731
58	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.29150318
59	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.29007608
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28387953
61	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.27132029
62	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.25421076
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25148389
64	ERA_21632823_ChIP-Seq_H3396_Human	1.24034241
65	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.23832882
66	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.23039231
67	NCOR_22424771_ChIP-Seq_293T_Human	1.21979185
68	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.19485815
69	RNF2_27304074_Chip-Seq_NSC_Mouse	1.18786179
70	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18539503
71	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.18087771
72	MYC_19829295_ChIP-Seq_ESCs_Human	1.17103031
73	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.15039929
74	CDX2_22108803_ChIP-Seq_LS180_Human	1.13101366
75	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.12977259
76	NANOG_20526341_ChIP-Seq_ESCs_Human	1.11426090
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11241215
78	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.11096380
79	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.10354034
80	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.10305071
81	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.09055512
82	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.07525153
83	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07112437
84	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06393634
85	AR_20517297_ChIP-Seq_VCAP_Human	1.05393145
86	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.04266583
87	P53_21459846_ChIP-Seq_SAOS-2_Human	1.03056568
88	REST_21632747_ChIP-Seq_MESCs_Mouse	1.02967835
89	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02886323
90	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.99041132
91	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.97751942
92	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.97469508
93	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.95173937
94	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.94416808
95	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.92772549
96	OCT4_20526341_ChIP-Seq_ESCs_Human	0.92697307
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92191597
98	PHF8_20622853_ChIP-Seq_HELA_Human	0.91811163
99	ETV1_20927104_ChIP-Seq_GIST48_Human	0.90514224
100	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.89096727

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.79507759
2	MP0006292_abnormal_olfactory_placode	2.72840132
3	MP0005410_abnormal_fertilization	2.69208200
4	MP0004133_heterotaxia	2.43047625
5	MP0003718_maternal_effect	2.28435852
6	MP0003136_yellow_coat_color	2.25736444
7	MP0005551_abnormal_eye_electrophysiolog	2.24635473
8	MP0003195_calcinosis	2.23468809
9	MP0003890_abnormal_embryonic-extraembry	2.17423268
10	MP0001968_abnormal_touch/_nociception	2.00502886
11	MP0002102_abnormal_ear_morphology	1.91042513
12	MP0006072_abnormal_retinal_apoptosis	1.85828686
13	MP0000569_abnormal_digit_pigmentation	1.73890859
14	MP0003119_abnormal_digestive_system	1.72901028
15	MP0002254_reproductive_system_inflammat	1.70854924
16	MP0002736_abnormal_nociception_after	1.70316500
17	MP0002234_abnormal_pharynx_morphology	1.67785267
18	MP0005084_abnormal_gallbladder_morpholo	1.66454816
19	MP0005377_hearing/vestibular/ear_phenot	1.65979241
20	MP0003878_abnormal_ear_physiology	1.65979241
21	MP0001485_abnormal_pinna_reflex	1.62083545
22	MP0003693_abnormal_embryo_hatching	1.62061365
23	MP0005253_abnormal_eye_physiology	1.61589210
24	MP0008872_abnormal_physiological_respon	1.61300912
25	MP0005645_abnormal_hypothalamus_physiol	1.59568250
26	MP0009046_muscle_twitch	1.57258449
27	MP0002938_white_spotting	1.55866447
28	MP0004043_abnormal_pH_regulation	1.52650643
29	MP0008789_abnormal_olfactory_epithelium	1.51932246
30	MP0003698_abnormal_male_reproductive	1.49318374
31	MP0006276_abnormal_autonomic_nervous	1.45358191
32	MP0003646_muscle_fatigue	1.42479694
33	MP0000427_abnormal_hair_cycle	1.39938547
34	MP0001929_abnormal_gametogenesis	1.39147781
35	MP0002928_abnormal_bile_duct	1.36167177
36	MP0002653_abnormal_ependyma_morphology	1.35592932
37	MP0004019_abnormal_vitamin_homeostasis	1.33419297
38	MP0003937_abnormal_limbs/digits/tail_de	1.32127174
39	MP0009745_abnormal_behavioral_response	1.31223203
40	MP0005670_abnormal_white_adipose	1.28555469
41	MP0001501_abnormal_sleep_pattern	1.26226092
42	MP0000631_abnormal_neuroendocrine_gland	1.26174768
43	MP0008875_abnormal_xenobiotic_pharmacok	1.24827515
44	MP0002735_abnormal_chemical_nociception	1.24452899
45	MP0002138_abnormal_hepatobiliary_system	1.23214180
46	MP0002163_abnormal_gland_morphology	1.22083407
47	MP0002272_abnormal_nervous_system	1.21453130
48	MP0002733_abnormal_thermal_nociception	1.20167077
49	MP0000647_abnormal_sebaceous_gland	1.19778187
50	MP0001986_abnormal_taste_sensitivity	1.18119356
51	MP0002160_abnormal_reproductive_system	1.17948974
52	MP0010386_abnormal_urinary_bladder	1.17865261
53	MP0005394_taste/olfaction_phenotype	1.16014986
54	MP0005499_abnormal_olfactory_system	1.16014986
55	MP0000372_irregular_coat_pigmentation	1.15557419
56	MP0005646_abnormal_pituitary_gland	1.15324088
57	MP0001188_hyperpigmentation	1.15290961
58	MP0008058_abnormal_DNA_repair	1.13326660
59	MP0002210_abnormal_sex_determination	1.12695130
60	MP0002557_abnormal_social/conspecific_i	1.11520006
61	MP0003787_abnormal_imprinting	1.10719819
62	MP0001486_abnormal_startle_reflex	1.09661221
63	MP0002837_dystrophic_cardiac_calcinosis	1.09513562
64	MP0000383_abnormal_hair_follicle	1.09050458
65	MP0005083_abnormal_biliary_tract	1.08946494
66	MP0001984_abnormal_olfaction	1.06406128
67	MP0005195_abnormal_posterior_eye	1.04523222
68	MP0005389_reproductive_system_phenotype	1.03934509
69	MP0001293_anophthalmia	1.02889083
70	MP0003011_delayed_dark_adaptation	0.98976719
71	MP0004885_abnormal_endolymph	0.98374072
72	MP0001970_abnormal_pain_threshold	0.97860154
73	MP0005395_other_phenotype	0.97790899
74	MP0002638_abnormal_pupillary_reflex	0.97668545
75	MP0002277_abnormal_respiratory_mucosa	0.96632828
76	MP0002572_abnormal_emotion/affect_behav	0.95240254
77	MP0003880_abnormal_central_pattern	0.94881001
78	MP0002752_abnormal_somatic_nervous	0.94761149
79	MP0000026_abnormal_inner_ear	0.94576896
80	MP0004742_abnormal_vestibular_system	0.93777044
81	MP0009697_abnormal_copulation	0.93321327
82	MP0004147_increased_porphyrin_level	0.92776003
83	MP0001529_abnormal_vocalization	0.92040036
84	MP0000230_abnormal_systemic_arterial	0.91719075
85	MP0005174_abnormal_tail_pigmentation	0.91681244
86	MP0002184_abnormal_innervation	0.91005229
87	MP0000653_abnormal_sex_gland	0.90628398
88	MP0005379_endocrine/exocrine_gland_phen	0.90199008
89	MP0005085_abnormal_gallbladder_physiolo	0.89994205
90	MP0000049_abnormal_middle_ear	0.89457444
91	MP0001286_abnormal_eye_development	0.88716985
92	MP0000470_abnormal_stomach_morphology	0.87634619
93	MP0001919_abnormal_reproductive_system	0.86187699
94	MP0004142_abnormal_muscle_tone	0.84424677
95	MP0002876_abnormal_thyroid_physiology	0.84401272
96	MP0001145_abnormal_male_reproductive	0.82909979
97	MP0003137_abnormal_impulse_conducting	0.81112523
98	MP0000778_abnormal_nervous_system	0.80762015
99	MP0002161_abnormal_fertility/fecundity	0.80736242
100	MP0004215_abnormal_myocardial_fiber	0.80345219

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.05223144
2	Abnormality of midbrain morphology (HP:0002418)	3.76600245
3	Molar tooth sign on MRI (HP:0002419)	3.76600245
4	Pancreatic fibrosis (HP:0100732)	3.74898355
5	True hermaphroditism (HP:0010459)	3.64083262
6	Congenital stationary night blindness (HP:0007642)	3.44825891
7	Nephronophthisis (HP:0000090)	3.17406631
8	Abnormal drinking behavior (HP:0030082)	3.14140069
9	Polydipsia (HP:0001959)	3.14140069
10	Attenuation of retinal blood vessels (HP:0007843)	3.11104785
11	Abnormality of the renal medulla (HP:0100957)	2.83346972
12	Chronic hepatic failure (HP:0100626)	2.81244265
13	Hypomagnesemia (HP:0002917)	2.72940499
14	Absent/shortened dynein arms (HP:0200106)	2.66520407
15	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.66520407
16	Bony spicule pigmentary retinopathy (HP:0007737)	2.61116155
17	Pendular nystagmus (HP:0012043)	2.60835466
18	Type II lissencephaly (HP:0007260)	2.60788759
19	Abnormality of the labia minora (HP:0012880)	2.56756087
20	Cystic liver disease (HP:0006706)	2.56027483
21	Polyuria (HP:0000103)	2.55892297
22	Abnormality of the renal cortex (HP:0011035)	2.53642470
23	Medial flaring of the eyebrow (HP:0010747)	2.52199676
24	Sclerocornea (HP:0000647)	2.45427660
25	Abnormal ciliary motility (HP:0012262)	2.43777430
26	Tubular atrophy (HP:0000092)	2.42518434
27	Hyperalaninemia (HP:0003348)	2.39393262
28	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.39393262
29	Abnormality of alanine metabolism (HP:0010916)	2.39393262
30	Abolished electroretinogram (ERG) (HP:0000550)	2.36354844
31	Abnormality of macular pigmentation (HP:0008002)	2.35572381
32	Tetany (HP:0001281)	2.32014115
33	Anencephaly (HP:0002323)	2.31724584
34	Abnormal respiratory motile cilium physiology (HP:0012261)	2.28229598
35	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.28217340
36	Decreased central vision (HP:0007663)	2.26273668
37	Hypoplasia of the pons (HP:0012110)	2.25776480
38	Inability to walk (HP:0002540)	2.25361943
39	Abnormal respiratory motile cilium morphology (HP:0005938)	2.23096900
40	Abnormal respiratory epithelium morphology (HP:0012253)	2.23096900
41	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.22338068
42	Abnormality of the pons (HP:0007361)	2.22204637
43	Abnormal rod and cone electroretinograms (HP:0008323)	2.21145475
44	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.20295043
45	Aplasia/hypoplasia of the uterus (HP:0008684)	2.19500689
46	Progressive cerebellar ataxia (HP:0002073)	2.14144621
47	Optic nerve hypoplasia (HP:0000609)	2.12709882
48	Progressive inability to walk (HP:0002505)	2.12430080
49	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.10652870
50	Severe visual impairment (HP:0001141)	2.09957898
51	Abnormal urine output (HP:0012590)	2.08206330
52	Abnormality of magnesium homeostasis (HP:0004921)	2.07861797
53	Gait imbalance (HP:0002141)	2.07804015
54	Hyperglycinuria (HP:0003108)	2.06679713
55	Bilateral microphthalmos (HP:0007633)	2.06081993
56	Congenital primary aphakia (HP:0007707)	2.02835259
57	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.02101486
58	Amelogenesis imperfecta (HP:0000705)	2.00572193
59	Congenital, generalized hypertrichosis (HP:0004540)	1.99664073
60	Abnormal biliary tract physiology (HP:0012439)	1.98680092
61	Bile duct proliferation (HP:0001408)	1.98680092
62	Birth length less than 3rd percentile (HP:0003561)	1.98516856
63	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.97657528
64	Genetic anticipation (HP:0003743)	1.96836001
65	Genital tract atresia (HP:0001827)	1.95495923
66	Congenital hepatic fibrosis (HP:0002612)	1.92820610
67	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.92563570
68	Patellar aplasia (HP:0006443)	1.92299981
69	Vaginal atresia (HP:0000148)	1.92125018
70	Male pseudohermaphroditism (HP:0000037)	1.90582310
71	Chorioretinal atrophy (HP:0000533)	1.90371821
72	Abnormality of renal excretion (HP:0011036)	1.90182830
73	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.89391778
74	Abnormal protein N-linked glycosylation (HP:0012347)	1.89391778
75	Abnormal protein glycosylation (HP:0012346)	1.89391778
76	Abnormal glycosylation (HP:0012345)	1.89391778
77	Type I transferrin isoform profile (HP:0003642)	1.87699413
78	Gaze-evoked nystagmus (HP:0000640)	1.86903024
79	Abnormality of the ileum (HP:0001549)	1.86437037
80	Postaxial foot polydactyly (HP:0001830)	1.86267896
81	Increased CSF lactate (HP:0002490)	1.85884420
82	Keratoconus (HP:0000563)	1.85242034
83	Increased corneal curvature (HP:0100692)	1.85242034
84	Furrowed tongue (HP:0000221)	1.83887939
85	Cerebellar dysplasia (HP:0007033)	1.83656372
86	Decreased circulating renin level (HP:0003351)	1.83364117
87	Aplasia/Hypoplasia of the patella (HP:0006498)	1.82923630
88	Clumsiness (HP:0002312)	1.81765699
89	Meckel diverticulum (HP:0002245)	1.81263953
90	Nephrogenic diabetes insipidus (HP:0009806)	1.80809814
91	Hypoplastic ischia (HP:0003175)	1.80175901
92	Preaxial hand polydactyly (HP:0001177)	1.79178998
93	Fibular aplasia (HP:0002990)	1.79119668
94	Hypothermia (HP:0002045)	1.78285123
95	Hypoplasia of the uterus (HP:0000013)	1.76834493
96	Lissencephaly (HP:0001339)	1.76396053
97	Oligodactyly (hands) (HP:0001180)	1.75109080
98	Median cleft lip (HP:0000161)	1.75069648
99	Optic disc pallor (HP:0000543)	1.74590569
100	Lipid accumulation in hepatocytes (HP:0006561)	1.74123306

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.58175833
2	WNK4	3.87836978
3	ZAK	3.21546194
4	STK39	3.11747143
5	BMPR1B	2.77025665
6	MST4	2.73265494
7	ACVR1B	2.63654823
8	ADRBK2	2.52229917
9	WNK3	2.51705077
10	MAP4K2	2.38455385
11	TNIK	2.30235519
12	TLK1	2.21724217
13	NUAK1	2.12306355
14	OXSR1	2.09437730
15	INSRR	2.02661025
16	MST1R	1.94526232
17	GRK1	1.85076172
18	PLK4	1.84485699
19	PINK1	1.74802571
20	MKNK2	1.59846965
21	EPHA2	1.46955119
22	STK38L	1.42500385
23	TRIM28	1.37846030
24	MAP3K9	1.37837179
25	PNCK	1.35711682
26	MET	1.33876769
27	CASK	1.31192261
28	DYRK3	1.14581633
29	MAPK13	1.12669019
30	MAPK15	1.12287721
31	PBK	1.10377191
32	LMTK2	0.98257109
33	DYRK2	0.97210578
34	TSSK6	0.96423472
35	ADRBK1	0.95067875
36	PLK2	0.94568873
37	PLK3	0.93186157
38	PHKG1	0.90234238
39	PHKG2	0.90234238
40	PRKCE	0.87946694
41	PTK2B	0.87855275
42	NEK2	0.86536644
43	STK16	0.83582325
44	MKNK1	0.83488105
45	VRK1	0.81002633
46	ERBB4	0.80601168
47	LATS1	0.80334638
48	TGFBR1	0.78529908
49	DAPK2	0.78263706
50	WNK1	0.77291406
51	BRSK1	0.77087739
52	NME1	0.75494444
53	TAOK3	0.75492023
54	PLK1	0.74414203
55	PRKCG	0.74204612
56	BRSK2	0.72397570
57	MAP2K6	0.71321232
58	STK3	0.71250201
59	MARK1	0.61836350
60	BUB1	0.58763762
61	MAP2K7	0.58081133
62	BCR	0.57547409
63	CHEK2	0.55607472
64	CSNK1A1L	0.53564450
65	CDK19	0.53271693
66	MAP3K4	0.52684931
67	CSNK1G1	0.52611355
68	TTK	0.52175465
69	PDK2	0.51859986
70	EPHB2	0.51853391
71	PRKCI	0.51719333
72	PKN1	0.51498540
73	PAK3	0.49994457
74	WEE1	0.44770811
75	VRK2	0.43754757
76	CDC7	0.43223487
77	CSNK1G3	0.43219822
78	STK38	0.42163835
79	NLK	0.41205333
80	CSNK1G2	0.40469702
81	CAMK2A	0.40104908
82	CSNK1A1	0.39264427
83	CDK3	0.37149549
84	CAMK1G	0.36814404
85	PRKCQ	0.32846806
86	TAF1	0.31910860
87	EIF2AK3	0.31884343
88	ERBB2	0.31112682
89	ATM	0.30834191
90	PRKCZ	0.30810725
91	ATR	0.30709127
92	RPS6KA5	0.30650542
93	MELK	0.30141791
94	PRKACA	0.29805202
95	DMPK	0.29338469
96	TIE1	0.28339535
97	CAMK1	0.28080321
98	IRAK1	0.27726360
99	BCKDK	0.27340050
100	NEK1	0.27269329

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.94675025
2	Basal transcription factors_Homo sapiens_hsa03022	2.42566232
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.39939904
4	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.38509579
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.30821760
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.14421190
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.12956563
8	RNA polymerase_Homo sapiens_hsa03020	2.09867264
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.07604621
10	Butanoate metabolism_Homo sapiens_hsa00650	2.04695906
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.04619649
12	Homologous recombination_Homo sapiens_hsa03440	2.01028977
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.94354703
14	Olfactory transduction_Homo sapiens_hsa04740	1.90699091
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.87867592
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.82641820
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.80710443
18	Oxidative phosphorylation_Homo sapiens_hsa00190	1.78668896
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.78416172
20	Nicotine addiction_Homo sapiens_hsa05033	1.76463337
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.74093096
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.68934743
23	One carbon pool by folate_Homo sapiens_hsa00670	1.60032286
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.52223703
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.47470069
26	Propanoate metabolism_Homo sapiens_hsa00640	1.45123550
27	Taste transduction_Homo sapiens_hsa04742	1.42271813
28	Caffeine metabolism_Homo sapiens_hsa00232	1.38063444
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.34668100
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.33036967
31	Proteasome_Homo sapiens_hsa03050	1.32553506
32	RNA degradation_Homo sapiens_hsa03018	1.31384866
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.31317399
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.30948772
35	Parkinsons disease_Homo sapiens_hsa05012	1.30177305
36	Huntingtons disease_Homo sapiens_hsa05016	1.24041931
37	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.22981087
38	Protein export_Homo sapiens_hsa03060	1.20045694
39	Retinol metabolism_Homo sapiens_hsa00830	1.16697687
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.14720258
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.13690676
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.12190523
43	beta-Alanine metabolism_Homo sapiens_hsa00410	1.12156132
44	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.08787188
45	Purine metabolism_Homo sapiens_hsa00230	1.03880374
46	Fat digestion and absorption_Homo sapiens_hsa04975	1.00085358
47	Morphine addiction_Homo sapiens_hsa05032	0.99450103
48	Peroxisome_Homo sapiens_hsa04146	0.98371614
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.97882308
50	Non-homologous end-joining_Homo sapiens_hsa03450	0.97261971
51	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.94097390
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.93170771
53	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.93020068
54	Steroid biosynthesis_Homo sapiens_hsa00100	0.88740537
55	ABC transporters_Homo sapiens_hsa02010	0.88688316
56	Basal cell carcinoma_Homo sapiens_hsa05217	0.88142512
57	Glycerolipid metabolism_Homo sapiens_hsa00561	0.88084022
58	RNA transport_Homo sapiens_hsa03013	0.87771871
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.87564170
60	Pyrimidine metabolism_Homo sapiens_hsa00240	0.86194488
61	Histidine metabolism_Homo sapiens_hsa00340	0.83971175
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.83716678
63	Alzheimers disease_Homo sapiens_hsa05010	0.82911710
64	Metabolic pathways_Homo sapiens_hsa01100	0.77334518
65	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.76327270
66	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.75205014
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.74293499
68	Cardiac muscle contraction_Homo sapiens_hsa04260	0.73997229
69	Sulfur relay system_Homo sapiens_hsa04122	0.71215731
70	Serotonergic synapse_Homo sapiens_hsa04726	0.68630417
71	Regulation of autophagy_Homo sapiens_hsa04140	0.68412982
72	Circadian entrainment_Homo sapiens_hsa04713	0.65733969
73	Hippo signaling pathway_Homo sapiens_hsa04390	0.64355438
74	GABAergic synapse_Homo sapiens_hsa04727	0.64295052
75	Glutathione metabolism_Homo sapiens_hsa00480	0.63239026
76	Ribosome_Homo sapiens_hsa03010	0.62709590
77	Arginine and proline metabolism_Homo sapiens_hsa00330	0.61965045
78	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.61311037
79	Glutamatergic synapse_Homo sapiens_hsa04724	0.59306201
80	Salivary secretion_Homo sapiens_hsa04970	0.58989289
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.58949831
82	Insulin secretion_Homo sapiens_hsa04911	0.58529314
83	Fatty acid degradation_Homo sapiens_hsa00071	0.58279425
84	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.57471307
85	Calcium signaling pathway_Homo sapiens_hsa04020	0.55547952
86	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.55351219
87	Mismatch repair_Homo sapiens_hsa03430	0.53867451
88	Pyruvate metabolism_Homo sapiens_hsa00620	0.52231609
89	Mineral absorption_Homo sapiens_hsa04978	0.51916757
90	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.51808423
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.51694391
92	Tight junction_Homo sapiens_hsa04530	0.51199507
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.50180634
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.49310223
95	Nucleotide excision repair_Homo sapiens_hsa03420	0.46637962
96	Base excision repair_Homo sapiens_hsa03410	0.46546290
97	Circadian rhythm_Homo sapiens_hsa04710	0.45891662
98	Sphingolipid metabolism_Homo sapiens_hsa00600	0.44471974
99	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44452653
100	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.44100953

LINC01057

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »