ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.42667833
2	tryptophan catabolic process (GO:0006569)	4.36083919
3	indole-containing compound catabolic process (GO:0042436)	4.36083919
4	indolalkylamine catabolic process (GO:0046218)	4.36083919
5	indolalkylamine metabolic process (GO:0006586)	4.34175694
6	L-fucose catabolic process (GO:0042355)	4.18314373
7	fucose catabolic process (GO:0019317)	4.18314373
8	L-fucose metabolic process (GO:0042354)	4.18314373
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.15107149
10	DNA deamination (GO:0045006)	4.09700031
11	response to pheromone (GO:0019236)	4.02868623
12	piRNA metabolic process (GO:0034587)	4.01262676
13	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.87534923
14	tryptophan metabolic process (GO:0006568)	3.84419298
15	kynurenine metabolic process (GO:0070189)	3.81847999
16	platelet dense granule organization (GO:0060155)	3.48263566
17	axoneme assembly (GO:0035082)	3.48156097
18	epithelial cilium movement (GO:0003351)	3.46618479
19	negative regulation of telomere maintenance (GO:0032205)	3.42686857
20	cellular ketone body metabolic process (GO:0046950)	3.31862133
21	detection of light stimulus involved in visual perception (GO:0050908)	3.30836913
22	detection of light stimulus involved in sensory perception (GO:0050962)	3.30836913
23	indole-containing compound metabolic process (GO:0042430)	3.30076725
24	cilium or flagellum-dependent cell motility (GO:0001539)	3.23689058
25	DNA methylation involved in gamete generation (GO:0043046)	3.08098101
26	ketone body metabolic process (GO:1902224)	3.06575442
27	cilium movement (GO:0003341)	3.06223469
28	amine catabolic process (GO:0009310)	3.05086503
29	cellular biogenic amine catabolic process (GO:0042402)	3.05086503
30	water-soluble vitamin biosynthetic process (GO:0042364)	3.01164859
31	multicellular organism reproduction (GO:0032504)	3.00001907
32	sulfation (GO:0051923)	2.99027438
33	ubiquinone biosynthetic process (GO:0006744)	2.98958870
34	protein polyglutamylation (GO:0018095)	2.96543205
35	negative regulation of mast cell activation (GO:0033004)	2.95038326
36	primary amino compound metabolic process (GO:1901160)	2.91989589
37	protein K11-linked deubiquitination (GO:0035871)	2.91737254
38	neuronal action potential (GO:0019228)	2.90662911
39	neural tube formation (GO:0001841)	2.87001620
40	cornea development in camera-type eye (GO:0061303)	2.83714292
41	reflex (GO:0060004)	2.82650328
42	preassembly of GPI anchor in ER membrane (GO:0016254)	2.81044250
43	gamma-aminobutyric acid transport (GO:0015812)	2.79563821
44	photoreceptor cell maintenance (GO:0045494)	2.79368769
45	dopamine transport (GO:0015872)	2.79343578
46	nonmotile primary cilium assembly (GO:0035058)	2.79244821
47	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.78535311
48	protein complex biogenesis (GO:0070271)	2.77102555
49	ubiquinone metabolic process (GO:0006743)	2.76718511
50	regulation of cilium movement (GO:0003352)	2.75690824
51	protein-cofactor linkage (GO:0018065)	2.75151424
52	regulation of action potential (GO:0098900)	2.74645899
53	rRNA catabolic process (GO:0016075)	2.73473839
54	positive regulation of fatty acid transport (GO:2000193)	2.72701215
55	respiratory chain complex IV assembly (GO:0008535)	2.72537438
56	cilium morphogenesis (GO:0060271)	2.69944653
57	mannosylation (GO:0097502)	2.69088770
58	auditory receptor cell stereocilium organization (GO:0060088)	2.67305476
59	serotonin metabolic process (GO:0042428)	2.66989846
60	positive regulation of defense response to virus by host (GO:0002230)	2.66224907
61	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.65036341
62	NADH dehydrogenase complex assembly (GO:0010257)	2.65036341
63	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.65036341
64	synaptic transmission, cholinergic (GO:0007271)	2.61680948
65	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.59362250
66	retinal cone cell development (GO:0046549)	2.58543235
67	cytochrome complex assembly (GO:0017004)	2.58505491
68	S-adenosylmethionine metabolic process (GO:0046500)	2.58085427
69	cilium organization (GO:0044782)	2.56342034
70	adaptation of signaling pathway (GO:0023058)	2.55536704
71	mitochondrial respiratory chain complex assembly (GO:0033108)	2.54283242
72	photoreceptor cell development (GO:0042461)	2.54205466
73	protein import into peroxisome matrix (GO:0016558)	2.53846476
74	reciprocal meiotic recombination (GO:0007131)	2.53304787
75	reciprocal DNA recombination (GO:0035825)	2.53304787
76	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.51273456
77	kidney morphogenesis (GO:0060993)	2.51221333
78	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.50475384
79	behavioral response to ethanol (GO:0048149)	2.50275497
80	male meiosis (GO:0007140)	2.49549559
81	maturation of 5.8S rRNA (GO:0000460)	2.49543165
82	rhodopsin mediated signaling pathway (GO:0016056)	2.49112564
83	nephron epithelium morphogenesis (GO:0072088)	2.48548989
84	nephron tubule morphogenesis (GO:0072078)	2.48548989
85	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.48446294
86	cAMP catabolic process (GO:0006198)	2.48284446
87	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.47701062
88	protein localization to cilium (GO:0061512)	2.47198400
89	cilium assembly (GO:0042384)	2.47061755
90	regulation of memory T cell differentiation (GO:0043380)	2.46732030
91	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.45912288
92	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.42919389
93	sperm motility (GO:0030317)	2.42489703
94	recombinational repair (GO:0000725)	2.42349756
95	double-strand break repair via homologous recombination (GO:0000724)	2.41894129
96	positive regulation of prostaglandin secretion (GO:0032308)	2.41367455
97	aromatic amino acid family catabolic process (GO:0009074)	2.41041947
98	glycerophospholipid catabolic process (GO:0046475)	2.40368076
99	male meiosis I (GO:0007141)	2.39998862
100	quinone biosynthetic process (GO:1901663)	2.37126639

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.94856377
2	VDR_22108803_ChIP-Seq_LS180_Human	3.52446993
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.96499954
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.82457675
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.80548762
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.69181351
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.66425273
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.47193252
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.20089823
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.17654005
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.13077587
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.12608111
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06204798
14	FUS_26573619_Chip-Seq_HEK293_Human	1.96964447
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.95982212
16	EWS_26573619_Chip-Seq_HEK293_Human	1.94784540
17	P300_19829295_ChIP-Seq_ESCs_Human	1.93241796
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.79783949
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.77307968
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.76791674
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.76586941
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.71616032
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.70770272
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.65722699
25	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.58512371
26	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.57120092
27	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.54847310
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54013968
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.50778251
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.49648718
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49025071
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.48370574
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.48370574
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.47487456
35	STAT3_23295773_ChIP-Seq_U87_Human	1.47288411
36	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.43999230
37	AR_25329375_ChIP-Seq_VCAP_Human	1.43624794
38	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.42853435
39	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41289472
40	TCF4_23295773_ChIP-Seq_U87_Human	1.40549362
41	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.40364477
42	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40364477
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.39619109
44	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.39495313
45	SMAD4_21799915_ChIP-Seq_A2780_Human	1.39406043
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.38264428
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.38264428
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.37174197
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.37166820
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34897435
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34897435
52	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.33818634
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32268892
54	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.31815275
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.31100923
56	MYC_18940864_ChIP-ChIP_HL60_Human	1.30973146
57	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.30438870
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28856790
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.27922103
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27734048
61	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25287695
62	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.25284972
63	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24041191
64	REST_21632747_ChIP-Seq_MESCs_Mouse	1.23829896
65	NCOR_22424771_ChIP-Seq_293T_Human	1.22813355
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.21981535
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21922943
68	AR_21572438_ChIP-Seq_LNCaP_Human	1.21759487
69	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.20871496
70	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19984597
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19639620
72	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19038411
73	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18965901
74	AR_20517297_ChIP-Seq_VCAP_Human	1.18390089
75	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18246138
76	HOXB7_26014856_ChIP-Seq_BT474_Human	1.14994794
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14495263
78	RNF2_27304074_Chip-Seq_NSC_Mouse	1.10717888
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07792473
80	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.07170851
81	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.06694384
82	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.06147140
83	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.05048023
84	CDX2_22108803_ChIP-Seq_LS180_Human	1.04431051
85	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.03631391
86	MYC_19829295_ChIP-Seq_ESCs_Human	1.03590346
87	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02593054
88	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.01549378
89	GATA3_26560356_Chip-Seq_TH2_Human	1.00969002
90	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00818069
91	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00343776
92	ERA_21632823_ChIP-Seq_H3396_Human	1.00247804
93	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.99430802
94	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.99328993
95	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98496871
96	P53_22387025_ChIP-Seq_ESCs_Mouse	0.97972586
97	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.97815486
98	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.96324104
99	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96166670
100	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.95910387

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.24802409
2	MP0008877_abnormal_DNA_methylation	2.62176959
3	MP0002102_abnormal_ear_morphology	2.48642774
4	MP0005551_abnormal_eye_electrophysiolog	2.45692466
5	MP0000569_abnormal_digit_pigmentation	2.39362269
6	MP0002837_dystrophic_cardiac_calcinosis	2.38381763
7	MP0001968_abnormal_touch/_nociception	2.33527007
8	MP0003646_muscle_fatigue	2.29949130
9	MP0002876_abnormal_thyroid_physiology	2.22272302
10	MP0006072_abnormal_retinal_apoptosis	2.04626630
11	MP0009046_muscle_twitch	2.02825445
12	MP0001986_abnormal_taste_sensitivity	2.00175179
13	MP0000372_irregular_coat_pigmentation	1.99662512
14	MP0003136_yellow_coat_color	1.95796321
15	MP0005646_abnormal_pituitary_gland	1.94662007
16	MP0001501_abnormal_sleep_pattern	1.94613452
17	MP0008872_abnormal_physiological_respon	1.94266858
18	MP0009745_abnormal_behavioral_response	1.88578481
19	MP0008875_abnormal_xenobiotic_pharmacok	1.87891606
20	MP0005645_abnormal_hypothalamus_physiol	1.87302041
21	MP0002736_abnormal_nociception_after	1.86479069
22	MP0002638_abnormal_pupillary_reflex	1.83090212
23	MP0005253_abnormal_eye_physiology	1.80952821
24	MP0006292_abnormal_olfactory_placode	1.77730820
25	MP0004885_abnormal_endolymph	1.73336071
26	MP0004147_increased_porphyrin_level	1.69488637
27	MP0003787_abnormal_imprinting	1.63200630
28	MP0004043_abnormal_pH_regulation	1.63188871
29	MP0005174_abnormal_tail_pigmentation	1.61442225
30	MP0002272_abnormal_nervous_system	1.59483944
31	MP0003880_abnormal_central_pattern	1.55043296
32	MP0004142_abnormal_muscle_tone	1.51717279
33	MP0004145_abnormal_muscle_electrophysio	1.51187097
34	MP0002653_abnormal_ependyma_morphology	1.49883337
35	MP0001984_abnormal_olfaction	1.43366442
36	MP0006276_abnormal_autonomic_nervous	1.43264081
37	MP0001486_abnormal_startle_reflex	1.42868211
38	MP0002938_white_spotting	1.41120198
39	MP0005410_abnormal_fertilization	1.41060689
40	MP0000427_abnormal_hair_cycle	1.39429908
41	MP0002735_abnormal_chemical_nociception	1.38821774
42	MP0001485_abnormal_pinna_reflex	1.36125941
43	MP0010386_abnormal_urinary_bladder	1.33580298
44	MP0000631_abnormal_neuroendocrine_gland	1.33577866
45	MP0005389_reproductive_system_phenotype	1.33447237
46	MP0002138_abnormal_hepatobiliary_system	1.31427673
47	MP0005084_abnormal_gallbladder_morpholo	1.30478629
48	MP0004133_heterotaxia	1.30383569
49	MP0003011_delayed_dark_adaptation	1.27205732
50	MP0002572_abnormal_emotion/affect_behav	1.26662966
51	MP0005075_abnormal_melanosome_morpholog	1.24686645
52	MP0002733_abnormal_thermal_nociception	1.24441437
53	MP0002064_seizures	1.23793159
54	MP0002160_abnormal_reproductive_system	1.22202913
55	MP0001970_abnormal_pain_threshold	1.20521371
56	MP0005671_abnormal_response_to	1.18913218
57	MP0004742_abnormal_vestibular_system	1.16267596
58	MP0002928_abnormal_bile_duct	1.15427984
59	MP0001919_abnormal_reproductive_system	1.14867425
60	MP0005167_abnormal_blood-brain_barrier	1.14219513
61	MP0002277_abnormal_respiratory_mucosa	1.13442618
62	MP0002557_abnormal_social/conspecific_i	1.09687441
63	MP0002095_abnormal_skin_pigmentation	1.08117211
64	MP0001905_abnormal_dopamine_level	1.07439187
65	MP0000230_abnormal_systemic_arterial	1.06545953
66	MP0008995_early_reproductive_senescence	1.06519573
67	MP0002067_abnormal_sensory_capabilities	1.04851496
68	MP0000383_abnormal_hair_follicle	0.97423067
69	MP0004924_abnormal_behavior	0.96546849
70	MP0005386_behavior/neurological_phenoty	0.96546849
71	MP0008775_abnormal_heart_ventricle	0.96322877
72	MP0005195_abnormal_posterior_eye	0.95995337
73	MP0002163_abnormal_gland_morphology	0.95518540
74	MP0004215_abnormal_myocardial_fiber	0.94936434
75	MP0002063_abnormal_learning/memory/cond	0.91556629
76	MP0005379_endocrine/exocrine_gland_phen	0.91441027
77	MP0003698_abnormal_male_reproductive	0.91222942
78	MP0003635_abnormal_synaptic_transmissio	0.91009949
79	MP0003718_maternal_effect	0.90718924
80	MP0002693_abnormal_pancreas_physiology	0.89245321
81	MP0001502_abnormal_circadian_rhythm	0.87459284
82	MP0001764_abnormal_homeostasis	0.86786389
83	MP0003878_abnormal_ear_physiology	0.86550368
84	MP0005377_hearing/vestibular/ear_phenot	0.86550368
85	MP0001324_abnormal_eye_pigmentation	0.83726077
86	MP0001529_abnormal_vocalization	0.81510473
87	MP0002229_neurodegeneration	0.80623867
88	MP0005171_absent_coat_pigmentation	0.79898722
89	MP0001929_abnormal_gametogenesis	0.79867856
90	MP0002234_abnormal_pharynx_morphology	0.77549297
91	MP0002752_abnormal_somatic_nervous	0.77537715
92	MP0009764_decreased_sensitivity_to	0.75989918
93	MP0005332_abnormal_amino_acid	0.75385907
94	MP0003137_abnormal_impulse_conducting	0.74964049
95	MP0008789_abnormal_olfactory_epithelium	0.74595358
96	MP0000015_abnormal_ear_pigmentation	0.74037557
97	MP0002909_abnormal_adrenal_gland	0.73756519
98	MP0002210_abnormal_sex_determination	0.72496208
99	MP0000026_abnormal_inner_ear	0.72247447
100	MP0005448_abnormal_energy_balance	0.72026194

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.81647344
2	Pancreatic fibrosis (HP:0100732)	4.26611397
3	Congenital stationary night blindness (HP:0007642)	4.18091444
4	True hermaphroditism (HP:0010459)	4.15110951
5	Molar tooth sign on MRI (HP:0002419)	4.10229745
6	Abnormality of midbrain morphology (HP:0002418)	4.10229745
7	Type II lissencephaly (HP:0007260)	3.74755111
8	Nephronophthisis (HP:0000090)	3.61673061
9	Abnormality of the renal cortex (HP:0011035)	3.47397108
10	Abnormality of the renal medulla (HP:0100957)	3.23223788
11	Hyperventilation (HP:0002883)	3.08013276
12	Attenuation of retinal blood vessels (HP:0007843)	3.05277753
13	Cystic liver disease (HP:0006706)	3.03496249
14	Abolished electroretinogram (ERG) (HP:0000550)	3.01757707
15	Abnormal drinking behavior (HP:0030082)	2.95470185
16	Polydipsia (HP:0001959)	2.95470185
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.90369708
18	Medial flaring of the eyebrow (HP:0010747)	2.88633765
19	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.88129660
20	Absent/shortened dynein arms (HP:0200106)	2.88129660
21	Tubular atrophy (HP:0000092)	2.84987046
22	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.82559965
23	Cerebellar dysplasia (HP:0007033)	2.70725028
24	Abnormal respiratory motile cilium morphology (HP:0005938)	2.67537827
25	Abnormal respiratory epithelium morphology (HP:0012253)	2.67537827
26	Chronic hepatic failure (HP:0100626)	2.64769567
27	Gaze-evoked nystagmus (HP:0000640)	2.51605317
28	Abnormal ciliary motility (HP:0012262)	2.47399647
29	Bile duct proliferation (HP:0001408)	2.46345437
30	Abnormal biliary tract physiology (HP:0012439)	2.46345437
31	Pendular nystagmus (HP:0012043)	2.45216999
32	Renal cortical cysts (HP:0000803)	2.39545125
33	Inability to walk (HP:0002540)	2.38988589
34	Decreased central vision (HP:0007663)	2.38299357
35	Progressive cerebellar ataxia (HP:0002073)	2.38253681
36	Polyuria (HP:0000103)	2.33269639
37	Sclerocornea (HP:0000647)	2.32994299
38	Increased corneal curvature (HP:0100692)	2.31518596
39	Keratoconus (HP:0000563)	2.31518596
40	Furrowed tongue (HP:0000221)	2.28312273
41	Congenital hepatic fibrosis (HP:0002612)	2.27974920
42	Congenital, generalized hypertrichosis (HP:0004540)	2.27352545
43	Lissencephaly (HP:0001339)	2.24042152
44	Hyperalaninemia (HP:0003348)	2.22887925
45	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.22887925
46	Abnormality of alanine metabolism (HP:0010916)	2.22887925
47	Large for gestational age (HP:0001520)	2.21887397
48	Male pseudohermaphroditism (HP:0000037)	2.21435068
49	Anencephaly (HP:0002323)	2.20132203
50	Genetic anticipation (HP:0003743)	2.17433328
51	Progressive inability to walk (HP:0002505)	2.16339356
52	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.16246546
53	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.16197148
54	Clumsiness (HP:0002312)	2.15202321
55	Gait imbalance (HP:0002141)	2.14444489
56	Hypothermia (HP:0002045)	2.08940718
57	Bony spicule pigmentary retinopathy (HP:0007737)	2.07287321
58	Stomach cancer (HP:0012126)	2.06764342
59	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.06417768
60	Congenital primary aphakia (HP:0007707)	2.05969671
61	Abnormal respiratory motile cilium physiology (HP:0012261)	2.04385071
62	Protruding tongue (HP:0010808)	2.03756638
63	Congenital sensorineural hearing impairment (HP:0008527)	2.03107553
64	Concave nail (HP:0001598)	1.99980522
65	Increased CSF lactate (HP:0002490)	1.98113618
66	Broad-based gait (HP:0002136)	1.97379485
67	Mitochondrial inheritance (HP:0001427)	1.96228891
68	Severe muscular hypotonia (HP:0006829)	1.95774915
69	Febrile seizures (HP:0002373)	1.95587485
70	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.95017201
71	Stomatitis (HP:0010280)	1.92402114
72	Nephrogenic diabetes insipidus (HP:0009806)	1.92380021
73	Decreased circulating renin level (HP:0003351)	1.89874639
74	Postaxial foot polydactyly (HP:0001830)	1.89625065
75	Fair hair (HP:0002286)	1.87208611
76	Retinal dysplasia (HP:0007973)	1.86379197
77	Absent speech (HP:0001344)	1.86327567
78	Abnormality of the pons (HP:0007361)	1.85975283
79	Methylmalonic acidemia (HP:0002912)	1.84927708
80	Hypoplasia of the pons (HP:0012110)	1.84564242
81	Abnormal urine output (HP:0012590)	1.83989833
82	Pachygyria (HP:0001302)	1.83343684
83	Hemiparesis (HP:0001269)	1.83200447
84	Asplenia (HP:0001746)	1.82106776
85	3-Methylglutaconic aciduria (HP:0003535)	1.79873578
86	Patellar aplasia (HP:0006443)	1.78831232
87	Acute necrotizing encephalopathy (HP:0006965)	1.78258719
88	Methylmalonic aciduria (HP:0012120)	1.77765508
89	Thyroiditis (HP:0100646)	1.77623264
90	Aplasia/hypoplasia of the uterus (HP:0008684)	1.76774206
91	Optic disc pallor (HP:0000543)	1.73938524
92	Optic nerve hypoplasia (HP:0000609)	1.73787447
93	Aplasia/Hypoplasia of the patella (HP:0006498)	1.71191309
94	Hypomagnesemia (HP:0002917)	1.71067967
95	Constricted visual fields (HP:0001133)	1.70773442
96	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.70573458
97	Ketosis (HP:0001946)	1.70315125
98	Genital tract atresia (HP:0001827)	1.69382915
99	Focal motor seizures (HP:0011153)	1.67939826
100	Hyperglycinuria (HP:0003108)	1.67059839

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.91389708
2	ADRBK2	3.53256174
3	BMPR1B	3.21777465
4	PINK1	2.89628635
5	TAOK3	2.79722714
6	ZAK	2.70851974
7	MAP4K2	2.68266390
8	GRK1	2.58046342
9	WNK3	2.47419949
10	ACVR1B	2.40056535
11	TLK1	2.40003153
12	NUAK1	2.19681410
13	WNK4	2.11218659
14	TXK	2.00888094
15	INSRR	1.96268945
16	MAPK13	1.74258074
17	MAP3K4	1.52899096
18	OXSR1	1.42980497
19	CASK	1.42009517
20	BCKDK	1.27923831
21	DAPK2	1.23768229
22	MKNK2	1.22618075
23	STK39	1.21858087
24	MAPK15	1.19601688
25	ADRBK1	1.15867665
26	TGFBR1	1.14738304
27	BRSK2	1.08347441
28	CAMKK2	1.02519653
29	MUSK	0.99464610
30	DYRK2	0.96814707
31	TIE1	0.96480425
32	PAK3	0.95003606
33	PRKCE	0.93259566
34	VRK1	0.92955354
35	IKBKB	0.90881953
36	KIT	0.88600922
37	MAP2K7	0.88563343
38	TNIK	0.88164667
39	STK38L	0.87609835
40	MAPKAPK3	0.87003634
41	TRIM28	0.86353862
42	TEC	0.85731424
43	PRKCG	0.84295168
44	PHKG1	0.82251981
45	PHKG2	0.82251981
46	NTRK3	0.80971662
47	MAP2K6	0.79920045
48	CSNK1G2	0.78843045
49	CSNK1G1	0.77802610
50	PRKCQ	0.77696743
51	CSNK1G3	0.77680477
52	PTK2B	0.76722327
53	MARK3	0.72412772
54	GRK7	0.72060544
55	MARK1	0.68961512
56	ITK	0.68909726
57	TNK2	0.68713661
58	PIK3CA	0.64435982
59	PKN1	0.62889372
60	CSNK1A1L	0.62662271
61	IRAK1	0.62285371
62	FGFR2	0.61764858
63	RPS6KA5	0.61164206
64	OBSCN	0.61112052
65	EPHA3	0.60617509
66	PRKCI	0.60502466
67	EIF2AK3	0.57954280
68	PLK2	0.57841792
69	MKNK1	0.55878549
70	PLK4	0.55360314
71	NEK2	0.55000163
72	SYK	0.54385849
73	WEE1	0.54049036
74	PNCK	0.53728102
75	MAPKAPK5	0.53287810
76	MST4	0.50158600
77	NLK	0.47953671
78	NTRK2	0.47445539
79	FLT3	0.46525411
80	CAMK2A	0.45911622
81	CHUK	0.45730831
82	TRPM7	0.45017467
83	PRKACA	0.44679936
84	CSNK1A1	0.42276686
85	PIK3CG	0.40852671
86	PRKCZ	0.38422578
87	STK11	0.38090016
88	CSNK1D	0.37875459
89	IKBKE	0.37101595
90	GRK5	0.36405260
91	PLK3	0.34234838
92	CAMK1	0.34208461
93	PRKCA	0.33985497
94	PRKAA2	0.33902929
95	FER	0.32998801
96	NME1	0.32896184
97	MAP2K2	0.31714684
98	DYRK1A	0.30422228
99	LYN	0.30158041
100	STK3	0.29922592

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.88254276
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.71991375
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.65951633
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.64089307
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.52420898
6	Butanoate metabolism_Homo sapiens_hsa00650	2.21419933
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10860140
8	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.02148833
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.99931888
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.99874409
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.98443752
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.97142555
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.91386390
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.90988895
15	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.88316363
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.87941007
17	Oxidative phosphorylation_Homo sapiens_hsa00190	1.84376715
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.78871649
19	Nicotine addiction_Homo sapiens_hsa05033	1.74341358
20	Homologous recombination_Homo sapiens_hsa03440	1.66412143
21	Asthma_Homo sapiens_hsa05310	1.60050477
22	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.53898128
23	RNA polymerase_Homo sapiens_hsa03020	1.51442786
24	Olfactory transduction_Homo sapiens_hsa04740	1.44266588
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.44167007
26	Caffeine metabolism_Homo sapiens_hsa00232	1.40094569
27	Parkinsons disease_Homo sapiens_hsa05012	1.39837788
28	Taste transduction_Homo sapiens_hsa04742	1.37688826
29	Protein export_Homo sapiens_hsa03060	1.36289564
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.35118920
31	Propanoate metabolism_Homo sapiens_hsa00640	1.34486690
32	Graft-versus-host disease_Homo sapiens_hsa05332	1.31209183
33	ABC transporters_Homo sapiens_hsa02010	1.30731610
34	Type I diabetes mellitus_Homo sapiens_hsa04940	1.30712637
35	Allograft rejection_Homo sapiens_hsa05330	1.27544138
36	Peroxisome_Homo sapiens_hsa04146	1.27247557
37	Primary immunodeficiency_Homo sapiens_hsa05340	1.23527792
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.23403236
39	Basal transcription factors_Homo sapiens_hsa03022	1.19661426
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.19542888
41	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.19096858
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.18741177
43	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.18327493
44	Morphine addiction_Homo sapiens_hsa05032	1.16113280
45	RNA degradation_Homo sapiens_hsa03018	1.14540093
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.13834055
47	Regulation of autophagy_Homo sapiens_hsa04140	1.12580759
48	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.11069042
49	One carbon pool by folate_Homo sapiens_hsa00670	1.10175336
50	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.08051826
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.00629418
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.94235067
53	Retinol metabolism_Homo sapiens_hsa00830	0.91628301
54	Cardiac muscle contraction_Homo sapiens_hsa04260	0.88474086
55	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.87783748
56	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.86548514
57	Huntingtons disease_Homo sapiens_hsa05016	0.86314738
58	Serotonergic synapse_Homo sapiens_hsa04726	0.85829826
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.85675375
60	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.84179664
61	Alzheimers disease_Homo sapiens_hsa05010	0.82904894
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80858571
63	Insulin secretion_Homo sapiens_hsa04911	0.79865887
64	GABAergic synapse_Homo sapiens_hsa04727	0.76318026
65	Circadian entrainment_Homo sapiens_hsa04713	0.75816374
66	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.74730926
67	Rheumatoid arthritis_Homo sapiens_hsa05323	0.72862262
68	Salivary secretion_Homo sapiens_hsa04970	0.70936971
69	Glutamatergic synapse_Homo sapiens_hsa04724	0.68381121
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68138453
71	Calcium signaling pathway_Homo sapiens_hsa04020	0.64893775
72	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.64493036
73	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.63809258
74	Purine metabolism_Homo sapiens_hsa00230	0.63765937
75	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.59407463
76	Histidine metabolism_Homo sapiens_hsa00340	0.57041447
77	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.56821747
78	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.56302964
79	Mineral absorption_Homo sapiens_hsa04978	0.55524430
80	Collecting duct acid secretion_Homo sapiens_hsa04966	0.53649453
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.52366233
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.52115361
83	Metabolic pathways_Homo sapiens_hsa01100	0.51548442
84	Sulfur metabolism_Homo sapiens_hsa00920	0.49140048
85	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.48183703
86	Circadian rhythm_Homo sapiens_hsa04710	0.44814394
87	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.41666639
88	Sulfur relay system_Homo sapiens_hsa04122	0.40815421
89	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.40304105
90	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.40266894
91	Fatty acid degradation_Homo sapiens_hsa00071	0.40166677
92	Antigen processing and presentation_Homo sapiens_hsa04612	0.40146419
93	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39302522
94	Proteasome_Homo sapiens_hsa03050	0.38350355
95	Pyrimidine metabolism_Homo sapiens_hsa00240	0.37555263
96	Non-homologous end-joining_Homo sapiens_hsa03450	0.37084278
97	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.36872520
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.31209020
99	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.28536984
100	cAMP signaling pathway_Homo sapiens_hsa04024	0.26069313

LINC01125

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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