ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fucose catabolic process (GO:0019317)	5.02759216
2	L-fucose metabolic process (GO:0042354)	5.02759216
3	L-fucose catabolic process (GO:0042355)	5.02759216
4	behavioral response to nicotine (GO:0035095)	4.75630665
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.08365971
6	indole-containing compound catabolic process (GO:0042436)	3.89892136
7	indolalkylamine catabolic process (GO:0046218)	3.89892136
8	tryptophan catabolic process (GO:0006569)	3.89892136
9	epithelial cilium movement (GO:0003351)	3.69358212
10	indolalkylamine metabolic process (GO:0006586)	3.68690710
11	regulation of guanylate cyclase activity (GO:0031282)	3.61588234
12	axoneme assembly (GO:0035082)	3.57164482
13	water-soluble vitamin biosynthetic process (GO:0042364)	3.54278477
14	exogenous drug catabolic process (GO:0042738)	3.47444390
15	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.46173958
16	regulation of cilium movement (GO:0003352)	3.45037777
17	sulfation (GO:0051923)	3.43395485
18	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.43049879
19	tryptophan metabolic process (GO:0006568)	3.40807094
20	drug catabolic process (GO:0042737)	3.36524714
21	DNA deamination (GO:0045006)	3.35617144
22	kidney morphogenesis (GO:0060993)	3.34299926
23	kynurenine metabolic process (GO:0070189)	3.33164479
24	positive regulation of guanylate cyclase activity (GO:0031284)	3.31407781
25	cellular ketone body metabolic process (GO:0046950)	3.30353205
26	cilium movement (GO:0003341)	3.23353536
27	cilium or flagellum-dependent cell motility (GO:0001539)	3.17539740
28	neural tube formation (GO:0001841)	3.14487286
29	respiratory chain complex IV assembly (GO:0008535)	3.09536226
30	rRNA catabolic process (GO:0016075)	3.02632106
31	fucosylation (GO:0036065)	3.01613245
32	photoreceptor cell maintenance (GO:0045494)	3.01289677
33	protein K11-linked deubiquitination (GO:0035871)	2.99084897
34	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.98711309
35	ketone body metabolic process (GO:1902224)	2.95725576
36	detection of light stimulus involved in sensory perception (GO:0050962)	2.93912511
37	detection of light stimulus involved in visual perception (GO:0050908)	2.93912511
38	response to pheromone (GO:0019236)	2.92968946
39	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.89505873
40	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.89505873
41	thyroid hormone metabolic process (GO:0042403)	2.87821030
42	positive regulation of fatty acid transport (GO:2000193)	2.87472951
43	piRNA metabolic process (GO:0034587)	2.86539175
44	cytochrome complex assembly (GO:0017004)	2.86403665
45	retinal cone cell development (GO:0046549)	2.85798943
46	protein complex biogenesis (GO:0070271)	2.85735154
47	arginine metabolic process (GO:0006525)	2.84974442
48	flavonoid metabolic process (GO:0009812)	2.84558639
49	negative regulation of telomere maintenance (GO:0032205)	2.78846245
50	proline transport (GO:0015824)	2.75433815
51	indole-containing compound metabolic process (GO:0042430)	2.74835055
52	platelet dense granule organization (GO:0060155)	2.74632926
53	alkaloid metabolic process (GO:0009820)	2.68082816
54	negative regulation of mast cell activation (GO:0033004)	2.66758460
55	amine catabolic process (GO:0009310)	2.66227387
56	cellular biogenic amine catabolic process (GO:0042402)	2.66227387
57	regulation of hexokinase activity (GO:1903299)	2.66192814
58	regulation of glucokinase activity (GO:0033131)	2.66192814
59	protein polyglutamylation (GO:0018095)	2.66010100
60	cilium morphogenesis (GO:0060271)	2.65552414
61	behavioral response to ethanol (GO:0048149)	2.64582092
62	axonemal dynein complex assembly (GO:0070286)	2.64474125
63	cytidine metabolic process (GO:0046087)	2.63317713
64	cytidine catabolic process (GO:0006216)	2.63317713
65	cytidine deamination (GO:0009972)	2.63317713
66	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.62886379
67	C4-dicarboxylate transport (GO:0015740)	2.62160010
68	digestion (GO:0007586)	2.61748603
69	quinone biosynthetic process (GO:1901663)	2.60397410
70	positive regulation of icosanoid secretion (GO:0032305)	2.58635524
71	positive regulation of prostaglandin secretion (GO:0032308)	2.57811522
72	neuronal action potential (GO:0019228)	2.56680577
73	preassembly of GPI anchor in ER membrane (GO:0016254)	2.56416093
74	glucuronate metabolic process (GO:0019585)	2.56240698
75	uronic acid metabolic process (GO:0006063)	2.56240698
76	cilium organization (GO:0044782)	2.55296811
77	oxidative demethylation (GO:0070989)	2.55000651
78	transepithelial transport (GO:0070633)	2.54914235
79	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.53839271
80	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.53839271
81	NADH dehydrogenase complex assembly (GO:0010257)	2.53839271
82	dopamine transport (GO:0015872)	2.53190810
83	intraciliary transport (GO:0042073)	2.51406552
84	DNA demethylation (GO:0080111)	2.51243981
85	mitochondrial respiratory chain complex assembly (GO:0033108)	2.50087779
86	replication fork processing (GO:0031297)	2.49573195
87	protein localization to cilium (GO:0061512)	2.49301002
88	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.48846290
89	auditory receptor cell stereocilium organization (GO:0060088)	2.47836240
90	drug metabolic process (GO:0017144)	2.47199097
91	benzene-containing compound metabolic process (GO:0042537)	2.46579963
92	cilium assembly (GO:0042384)	2.46067985
93	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.45994587
94	sulfate transmembrane transport (GO:1902358)	2.45352722
95	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.44766429
96	mannosylation (GO:0097502)	2.43535623
97	vitamin biosynthetic process (GO:0009110)	2.42762588
98	regulation of action potential (GO:0098900)	2.42033795
99	cellular glucuronidation (GO:0052695)	2.41938751
100	epoxygenase P450 pathway (GO:0019373)	2.41291739

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.48934826
2	VDR_22108803_ChIP-Seq_LS180_Human	3.37787186
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.06794160
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.89852267
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.45743124
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.40558939
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.40269904
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.37558656
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.21725634
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.10694010
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06662253
12	P300_19829295_ChIP-Seq_ESCs_Human	2.00552473
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.94709282
14	EWS_26573619_Chip-Seq_HEK293_Human	1.94154026
15	FUS_26573619_Chip-Seq_HEK293_Human	1.93422162
16	TAF15_26573619_Chip-Seq_HEK293_Human	1.89101883
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.88642662
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.86322342
19	EZH2_22144423_ChIP-Seq_EOC_Human	1.82681440
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.81913874
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.73224641
22	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.69108274
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.68015280
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.67568951
25	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.66911084
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.59647898
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.59148289
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.59148289
29	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.57942794
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53081652
31	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.51497682
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.50712232
33	AR_25329375_ChIP-Seq_VCAP_Human	1.50272114
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.47830515
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.47439353
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.47207573
37	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.47009193
38	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.46761333
39	TCF4_22108803_ChIP-Seq_LS180_Human	1.45287905
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45225604
41	STAT3_23295773_ChIP-Seq_U87_Human	1.44356736
42	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.43927422
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.43607394
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.43236383
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.43236383
46	NANOG_19829295_ChIP-Seq_ESCs_Human	1.42267981
47	SOX2_19829295_ChIP-Seq_ESCs_Human	1.42267981
48	TCF4_23295773_ChIP-Seq_U87_Human	1.41240655
49	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.39342607
50	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.37122261
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.36442961
52	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.35525096
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.35213449
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.34892407
55	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.34312940
56	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.32502850
57	CDX2_22108803_ChIP-Seq_LS180_Human	1.29728216
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.29690069
59	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.29618460
60	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.29306422
61	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28857224
62	AR_20517297_ChIP-Seq_VCAP_Human	1.28019704
63	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.27498307
64	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.27466121
65	MYC_18940864_ChIP-ChIP_HL60_Human	1.25044757
66	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.25024526
67	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24871895
68	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.24871895
69	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.24710439
70	NCOR_22424771_ChIP-Seq_293T_Human	1.23496768
71	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21127509
72	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19941849
73	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.17475154
74	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17419289
75	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.15975181
76	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.15181728
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.14492122
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14250823
79	HOXB7_26014856_ChIP-Seq_BT474_Human	1.14195978
80	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09612285
81	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.08880901
82	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08015852
83	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.07640524
84	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.07319372
85	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.07012396
86	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.06708741
87	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.06612996
88	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05806364
89	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05214120
90	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03647986
91	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.03258143
92	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.03256919
93	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.01930270
94	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01780488
95	NANOG_20526341_ChIP-Seq_ESCs_Human	1.01208567
96	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01024027
97	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.00818251
98	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99302635
99	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98489313
100	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.97640196

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004043_abnormal_pH_regulation	2.69830471
2	MP0008875_abnormal_xenobiotic_pharmacok	2.66643324
3	MP0003195_calcinosis	2.59646010
4	MP0005360_urolithiasis	2.50076386
5	MP0005085_abnormal_gallbladder_physiolo	2.44610481
6	MP0004147_increased_porphyrin_level	2.41049191
7	MP0005551_abnormal_eye_electrophysiolog	2.33276207
8	MP0002876_abnormal_thyroid_physiology	2.32718047
9	MP0008877_abnormal_DNA_methylation	2.28112880
10	MP0008872_abnormal_physiological_respon	2.05687991
11	MP0002102_abnormal_ear_morphology	1.94342757
12	MP0001501_abnormal_sleep_pattern	1.91266091
13	MP0002837_dystrophic_cardiac_calcinosis	1.90465064
14	MP0001968_abnormal_touch/_nociception	1.88935642
15	MP0002139_abnormal_hepatobiliary_system	1.83883470
16	MP0002138_abnormal_hepatobiliary_system	1.77553572
17	MP0005365_abnormal_bile_salt	1.75713010
18	MP0001485_abnormal_pinna_reflex	1.74561851
19	MP0003787_abnormal_imprinting	1.67649592
20	MP0006072_abnormal_retinal_apoptosis	1.67646373
21	MP0002653_abnormal_ependyma_morphology	1.63181760
22	MP0006292_abnormal_olfactory_placode	1.62529020
23	MP0004885_abnormal_endolymph	1.62302587
24	MP0003183_abnormal_peptide_metabolism	1.61539199
25	MP0000569_abnormal_digit_pigmentation	1.59083761
26	MP0000427_abnormal_hair_cycle	1.58886532
27	MP0002736_abnormal_nociception_after	1.57378244
28	MP0005646_abnormal_pituitary_gland	1.55899241
29	MP0001986_abnormal_taste_sensitivity	1.54711779
30	MP0005645_abnormal_hypothalamus_physiol	1.53960561
31	MP0005253_abnormal_eye_physiology	1.53655213
32	MP0003718_maternal_effect	1.53519528
33	MP0005174_abnormal_tail_pigmentation	1.52332937
34	MP0009745_abnormal_behavioral_response	1.51774674
35	MP0004019_abnormal_vitamin_homeostasis	1.51707242
36	MP0003880_abnormal_central_pattern	1.50560551
37	MP0002638_abnormal_pupillary_reflex	1.49017853
38	MP0000372_irregular_coat_pigmentation	1.47928824
39	MP0001666_abnormal_nutrient_absorption	1.47479894
40	MP0003252_abnormal_bile_duct	1.47243272
41	MP0002272_abnormal_nervous_system	1.42889651
42	MP0003646_muscle_fatigue	1.41007266
43	MP0005332_abnormal_amino_acid	1.36526634
44	MP0001764_abnormal_homeostasis	1.35860713
45	MP0002735_abnormal_chemical_nociception	1.35117045
46	MP0009046_muscle_twitch	1.33942686
47	MP0010329_abnormal_lipoprotein_level	1.32989879
48	MP0001486_abnormal_startle_reflex	1.29710090
49	MP0000631_abnormal_neuroendocrine_gland	1.28586159
50	MP0002938_white_spotting	1.27807165
51	MP0005084_abnormal_gallbladder_morpholo	1.27578640
52	MP0001664_abnormal_digestion	1.25843650
53	MP0010386_abnormal_urinary_bladder	1.23900096
54	MP0003806_abnormal_nucleotide_metabolis	1.23815654
55	MP0000230_abnormal_systemic_arterial	1.23797944
56	MP0001984_abnormal_olfaction	1.21455210
57	MP0002277_abnormal_respiratory_mucosa	1.21326002
58	MP0003011_delayed_dark_adaptation	1.20879079
59	MP0004142_abnormal_muscle_tone	1.20388178
60	MP0002733_abnormal_thermal_nociception	1.19927472
61	MP0003136_yellow_coat_color	1.16064677
62	MP0001188_hyperpigmentation	1.14604232
63	MP0001970_abnormal_pain_threshold	1.13912532
64	MP0006276_abnormal_autonomic_nervous	1.11906928
65	MP0002572_abnormal_emotion/affect_behav	1.11845719
66	MP0000538_abnormal_urinary_bladder	1.11156375
67	MP0002557_abnormal_social/conspecific_i	1.10602183
68	MP0001873_stomach_inflammation	1.08555524
69	MP0008961_abnormal_basal_metabolism	1.07747494
70	MP0002064_seizures	1.06275549
71	MP0005636_abnormal_mineral_homeostasis	1.06155114
72	MP0001765_abnormal_ion_homeostasis	1.05961258
73	MP0000383_abnormal_hair_follicle	1.04851762
74	MP0004133_heterotaxia	1.03799536
75	MP0005389_reproductive_system_phenotype	1.02396854
76	MP0002909_abnormal_adrenal_gland	1.01283144
77	MP0002234_abnormal_pharynx_morphology	1.00542926
78	MP0005167_abnormal_blood-brain_barrier	0.99249815
79	MP0004742_abnormal_vestibular_system	0.98001564
80	MP0005448_abnormal_energy_balance	0.97692016
81	MP0008995_early_reproductive_senescence	0.97468390
82	MP0001529_abnormal_vocalization	0.96322181
83	MP0004924_abnormal_behavior	0.95847216
84	MP0005386_behavior/neurological_phenoty	0.95847216
85	MP0001919_abnormal_reproductive_system	0.94074474
86	MP0004215_abnormal_myocardial_fiber	0.92841904
87	MP0008775_abnormal_heart_ventricle	0.92588686
88	MP0009643_abnormal_urine_homeostasis	0.92323673
89	MP0001756_abnormal_urination	0.86213440
90	MP0005310_abnormal_salivary_gland	0.85801392
91	MP0008058_abnormal_DNA_repair	0.83947934
92	MP0005410_abnormal_fertilization	0.81911878
93	MP0005195_abnormal_posterior_eye	0.81843017
94	MP0001905_abnormal_dopamine_level	0.81671809
95	MP0002734_abnormal_mechanical_nocicepti	0.81180134
96	MP0002160_abnormal_reproductive_system	0.81153944
97	MP0005670_abnormal_white_adipose	0.80182471
98	MP0009764_decreased_sensitivity_to	0.79987725
99	MP0000026_abnormal_inner_ear	0.78478194
100	MP0002067_abnormal_sensory_capabilities	0.78187349

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.32826184
2	True hermaphroditism (HP:0010459)	4.03769862
3	Pancreatic fibrosis (HP:0100732)	4.00734381
4	Abnormality of midbrain morphology (HP:0002418)	3.87895359
5	Molar tooth sign on MRI (HP:0002419)	3.87895359
6	Congenital stationary night blindness (HP:0007642)	3.75778476
7	Nephronophthisis (HP:0000090)	3.60470886
8	Hyperventilation (HP:0002883)	3.50046092
9	Decreased circulating renin level (HP:0003351)	3.38263206
10	Abnormality of the renal cortex (HP:0011035)	3.33144556
11	Abnormality of the renal medulla (HP:0100957)	3.23940243
12	Abolished electroretinogram (ERG) (HP:0000550)	3.00023375
13	Absent/shortened dynein arms (HP:0200106)	2.86667973
14	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.86667973
15	Attenuation of retinal blood vessels (HP:0007843)	2.86074750
16	Medial flaring of the eyebrow (HP:0010747)	2.79589781
17	Tubular atrophy (HP:0000092)	2.75528077
18	Cystic liver disease (HP:0006706)	2.72804951
19	Decreased central vision (HP:0007663)	2.72403719
20	Abnormal respiratory epithelium morphology (HP:0012253)	2.70504013
21	Abnormal respiratory motile cilium morphology (HP:0005938)	2.70504013
22	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.69446414
23	Congenital sensorineural hearing impairment (HP:0008527)	2.58173652
24	Chronic hepatic failure (HP:0100626)	2.57455324
25	Abnormality of vitamin B metabolism (HP:0004340)	2.55144926
26	Hyperglycinuria (HP:0003108)	2.54821004
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.52661886
28	Renal cortical cysts (HP:0000803)	2.50919116
29	Abnormal ciliary motility (HP:0012262)	2.42498151
30	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.41955721
31	Abnormality of renin-angiotensin system (HP:0000847)	2.41317030
32	Metabolic alkalosis (HP:0200114)	2.33461286
33	Congenital, generalized hypertrichosis (HP:0004540)	2.33030321
34	Large for gestational age (HP:0001520)	2.32995225
35	Abnormal drinking behavior (HP:0030082)	2.30772509
36	Polydipsia (HP:0001959)	2.30772509
37	Abnormality of urine glucose concentration (HP:0011016)	2.29999899
38	Glycosuria (HP:0003076)	2.29999899
39	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.24888636
40	Type II lissencephaly (HP:0007260)	2.24874226
41	Abnormality of proline metabolism (HP:0010907)	2.24523473
42	Hydroxyprolinuria (HP:0003080)	2.24523473
43	Stomach cancer (HP:0012126)	2.22988480
44	Mitochondrial inheritance (HP:0001427)	2.21945624
45	Sclerocornea (HP:0000647)	2.21378536
46	Furrowed tongue (HP:0000221)	2.19665720
47	Pendular nystagmus (HP:0012043)	2.19644191
48	Abnormality of glycine metabolism (HP:0010895)	2.19215041
49	Abnormality of serine family amino acid metabolism (HP:0010894)	2.19215041
50	Methylmalonic aciduria (HP:0012120)	2.19152029
51	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.17064055
52	Acute necrotizing encephalopathy (HP:0006965)	2.16462556
53	Increased CSF lactate (HP:0002490)	2.16118932
54	Inability to walk (HP:0002540)	2.16004776
55	Nephrogenic diabetes insipidus (HP:0009806)	2.14764538
56	Congenital hepatic fibrosis (HP:0002612)	2.14573986
57	Abnormal respiratory motile cilium physiology (HP:0012261)	2.13604850
58	Gait imbalance (HP:0002141)	2.13090440
59	Acute encephalopathy (HP:0006846)	2.11211705
60	Congenital primary aphakia (HP:0007707)	2.10940319
61	Fair hair (HP:0002286)	2.10573464
62	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10503385
63	Male pseudohermaphroditism (HP:0000037)	2.10285109
64	Lipid accumulation in hepatocytes (HP:0006561)	2.09472666
65	Progressive inability to walk (HP:0002505)	2.08374621
66	3-Methylglutaconic aciduria (HP:0003535)	2.07602742
67	Methylmalonic acidemia (HP:0002912)	2.06357104
68	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.06121432
69	Hypothermia (HP:0002045)	2.03922615
70	Anencephaly (HP:0002323)	2.02389100
71	Alkalosis (HP:0001948)	2.01344538
72	Broad-based gait (HP:0002136)	1.99661122
73	Keratoconus (HP:0000563)	1.98421673
74	Increased corneal curvature (HP:0100692)	1.98421673
75	Absent speech (HP:0001344)	1.97152678
76	Hyperactive renin-angiotensin system (HP:0000841)	1.96763030
77	Bile duct proliferation (HP:0001408)	1.95643451
78	Abnormal biliary tract physiology (HP:0012439)	1.95643451
79	Progressive macrocephaly (HP:0004481)	1.95489725
80	Gaze-evoked nystagmus (HP:0000640)	1.94700519
81	Ketosis (HP:0001946)	1.93813368
82	Postaxial foot polydactyly (HP:0001830)	1.93765115
83	Polyuria (HP:0000103)	1.90629906
84	Bony spicule pigmentary retinopathy (HP:0007737)	1.90155724
85	Intestinal atresia (HP:0011100)	1.90136991
86	Hypoplasia of the fovea (HP:0007750)	1.88879486
87	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.88879486
88	Rhinitis (HP:0012384)	1.88638560
89	Hepatocellular necrosis (HP:0001404)	1.88628217
90	Abnormality of the labia minora (HP:0012880)	1.88263762
91	Hyperaldosteronism (HP:0000859)	1.87451417
92	Abnormality of macular pigmentation (HP:0008002)	1.86678706
93	Optic disc pallor (HP:0000543)	1.86241959
94	Ketoacidosis (HP:0001993)	1.86213516
95	Hepatic necrosis (HP:0002605)	1.85029251
96	Aplasia/hypoplasia of the uterus (HP:0008684)	1.83307225
97	Pigmentary retinal degeneration (HP:0001146)	1.83214426
98	Hypomagnesemia (HP:0002917)	1.82910937
99	Lissencephaly (HP:0001339)	1.82867267
100	Abnormal mitochondria in muscle tissue (HP:0008316)	1.82437411

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.62271497
2	ACVR1B	3.61520036
3	WNK3	2.93108782
4	ADRBK2	2.90208514
5	BMPR1B	2.85532505
6	NUAK1	2.82128417
7	MAP4K2	2.53196026
8	PINK1	2.44991012
9	ZAK	2.44364085
10	GRK1	2.43456235
11	CASK	2.35972781
12	TAOK3	2.19780111
13	STK39	2.15890763
14	MST4	2.14382153
15	WNK4	2.05835963
16	OXSR1	2.04619329
17	TLK1	1.78608627
18	MAPK13	1.73210836
19	MAP3K4	1.51555139
20	TRIM28	1.50706342
21	INSRR	1.46673057
22	TNIK	1.44770044
23	TXK	1.32427145
24	DAPK2	1.23255272
25	STK16	1.12267812
26	MKNK2	1.09186379
27	PIK3CA	1.06780024
28	BCKDK	1.04512256
29	PAK3	1.03713263
30	CAMKK2	0.99953930
31	ADRBK1	0.98200819
32	MAP3K12	0.95077254
33	MAP2K7	0.95047151
34	PRKCE	0.92093506
35	STK38L	0.89425059
36	AKT3	0.86164864
37	DYRK2	0.84442735
38	EIF2AK3	0.78824712
39	BCR	0.78802973
40	FER	0.78565238
41	NEK2	0.74815054
42	VRK1	0.73951981
43	PRKCG	0.72817191
44	MAPKAPK3	0.71877021
45	ERBB3	0.70285366
46	PHKG2	0.69709954
47	PHKG1	0.69709954
48	NEK1	0.67685468
49	MAP2K6	0.67409435
50	IRAK1	0.66924020
51	TIE1	0.65237375
52	CSNK1G2	0.64965694
53	BRSK2	0.64298893
54	MAPK15	0.63698350
55	CSNK1G1	0.61768759
56	PTK2B	0.61245977
57	TEC	0.60573462
58	PLK4	0.59227534
59	PRKCQ	0.58791339
60	PLK2	0.58480311
61	MAPKAPK5	0.57105907
62	VRK2	0.56819081
63	STK3	0.56294127
64	KIT	0.55686227
65	PRKCI	0.55656579
66	TGFBR1	0.55312397
67	CSNK1G3	0.55152611
68	EPHA3	0.52247893
69	NTRK3	0.51980358
70	MARK1	0.51807338
71	CCNB1	0.51467168
72	CAMK2A	0.50721625
73	MKNK1	0.49574058
74	IKBKB	0.49124304
75	CSNK1A1L	0.47046350
76	PRKACA	0.46875697
77	PRKAA2	0.45946543
78	PRKCA	0.45640329
79	PRKG2	0.44810024
80	PRKCZ	0.44609684
81	ERBB2	0.44164618
82	FLT3	0.44039774
83	FGFR2	0.43133464
84	NLK	0.41200760
85	DYRK3	0.41044495
86	CSNK1A1	0.40369421
87	PLK3	0.40198123
88	EPHA4	0.39672885
89	STK11	0.39432961
90	NME1	0.36872454
91	TNK2	0.36831716
92	RPS6KA5	0.33724995
93	PRKG1	0.32485622
94	IGF1R	0.31580715
95	CHUK	0.31520520
96	CAMK2D	0.31256466
97	PDK2	0.30537427
98	ITK	0.29657735
99	CAMK1	0.28320841
100	MAP2K4	0.27280274

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	2.93356140
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.90914013
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.77715227
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.45720240
5	Fat digestion and absorption_Homo sapiens_hsa04975	2.26239851
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.21502343
7	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.11832954
8	Phototransduction_Homo sapiens_hsa04744	2.03180612
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.02424354
10	Chemical carcinogenesis_Homo sapiens_hsa05204	1.98652069
11	Ether lipid metabolism_Homo sapiens_hsa00565	1.96553337
12	Butanoate metabolism_Homo sapiens_hsa00650	1.91759534
13	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.91394542
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.89690767
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.88979758
16	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.87616108
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.85358960
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.84507730
19	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.75858009
20	Asthma_Homo sapiens_hsa05310	1.74337661
21	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.72143361
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.71482771
23	Retinol metabolism_Homo sapiens_hsa00830	1.70306782
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.69093998
25	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.65682004
26	Histidine metabolism_Homo sapiens_hsa00340	1.58362614
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.58050274
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.53400389
29	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.50777012
30	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.48146795
31	Propanoate metabolism_Homo sapiens_hsa00640	1.44281815
32	Mineral absorption_Homo sapiens_hsa04978	1.43624924
33	Parkinsons disease_Homo sapiens_hsa05012	1.42356139
34	Sulfur metabolism_Homo sapiens_hsa00920	1.36422407
35	Protein export_Homo sapiens_hsa03060	1.34492852
36	Nicotine addiction_Homo sapiens_hsa05033	1.33186078
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.30338318
38	Peroxisome_Homo sapiens_hsa04146	1.27488166
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.27275329
40	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.22924086
41	Homologous recombination_Homo sapiens_hsa03440	1.21174906
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.10457241
43	Selenocompound metabolism_Homo sapiens_hsa00450	1.06920667
44	Huntingtons disease_Homo sapiens_hsa05016	1.01156270
45	Renin-angiotensin system_Homo sapiens_hsa04614	1.00832341
46	Glycerolipid metabolism_Homo sapiens_hsa00561	1.00778312
47	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.00153325
48	Fatty acid degradation_Homo sapiens_hsa00071	0.99106306
49	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.98762842
50	Type I diabetes mellitus_Homo sapiens_hsa04940	0.96611697
51	Olfactory transduction_Homo sapiens_hsa04740	0.95692535
52	Allograft rejection_Homo sapiens_hsa05330	0.95592507
53	RNA polymerase_Homo sapiens_hsa03020	0.93234046
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.90848679
55	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.89863762
56	ABC transporters_Homo sapiens_hsa02010	0.87188177
57	Basal transcription factors_Homo sapiens_hsa03022	0.86893173
58	Taste transduction_Homo sapiens_hsa04742	0.85199813
59	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.84692724
60	Alzheimers disease_Homo sapiens_hsa05010	0.84338474
61	Fanconi anemia pathway_Homo sapiens_hsa03460	0.81928662
62	Graft-versus-host disease_Homo sapiens_hsa05332	0.78777460
63	RNA degradation_Homo sapiens_hsa03018	0.77094733
64	Insulin secretion_Homo sapiens_hsa04911	0.75934950
65	Serotonergic synapse_Homo sapiens_hsa04726	0.75858159
66	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.73337947
67	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.73035488
68	Protein digestion and absorption_Homo sapiens_hsa04974	0.70973277
69	Metabolic pathways_Homo sapiens_hsa01100	0.68315210
70	Glutathione metabolism_Homo sapiens_hsa00480	0.67489829
71	Cardiac muscle contraction_Homo sapiens_hsa04260	0.66729469
72	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.64550553
73	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.64465996
74	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.64191274
75	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.62988747
76	Regulation of autophagy_Homo sapiens_hsa04140	0.60353571
77	Proteasome_Homo sapiens_hsa03050	0.59400162
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58802198
79	Arginine and proline metabolism_Homo sapiens_hsa00330	0.58753313
80	Pancreatic secretion_Homo sapiens_hsa04972	0.57350498
81	Morphine addiction_Homo sapiens_hsa05032	0.57343935
82	Salivary secretion_Homo sapiens_hsa04970	0.57048626
83	Purine metabolism_Homo sapiens_hsa00230	0.55308756
84	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.54562159
85	PPAR signaling pathway_Homo sapiens_hsa03320	0.53827012
86	Sphingolipid metabolism_Homo sapiens_hsa00600	0.53313385
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.52857043
88	Bile secretion_Homo sapiens_hsa04976	0.50199636
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49650384
90	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.49038945
91	Arginine biosynthesis_Homo sapiens_hsa00220	0.48223263
92	Fatty acid metabolism_Homo sapiens_hsa01212	0.46890702
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.46700782
94	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.45875552
95	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.45042510
96	Circadian entrainment_Homo sapiens_hsa04713	0.44087777
97	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.41121998
98	Glutamatergic synapse_Homo sapiens_hsa04724	0.39817722
99	GABAergic synapse_Homo sapiens_hsa04727	0.37607060
100	Fatty acid elongation_Homo sapiens_hsa00062	0.36118333

LINC01207

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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