LINC01225

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of autophagic vacuole assembly (GO:2000785)9.44490136
2mast cell activation involved in immune response (GO:0002279)7.89727010
3mast cell degranulation (GO:0043303)7.89727010
4radial glial cell differentiation (GO:0060019)7.88901821
5regulation of vacuole organization (GO:0044088)7.86871178
6cellular response to lithium ion (GO:0071285)7.62263102
7regulation of receptor binding (GO:1900120)7.45745137
8histone H3-K36 demethylation (GO:0070544)7.23494878
9V(D)J recombination (GO:0033151)7.22391543
10tongue development (GO:0043586)6.58395034
11C21-steroid hormone biosynthetic process (GO:0006700)6.34185485
12negative regulation of macroautophagy (GO:0016242)6.23451506
13positive regulation of granulocyte differentiation (GO:0030854)6.10615870
14regulation of interleukin-13 production (GO:0032656)6.01334562
15mast cell activation (GO:0045576)5.88661900
16negative regulation of bone resorption (GO:0045779)5.65462454
17omega-hydroxylase P450 pathway (GO:0097267)5.45852423
18regulation of granulocyte differentiation (GO:0030852)5.40659349
19detection of chemical stimulus involved in sensory perception of smell (GO:0050911)5.38925496
20negative regulation of T cell apoptotic process (GO:0070233)5.30093223
21negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.11110612
22positive regulation by host of viral transcription (GO:0043923)5.05007805
23negative regulation of organelle assembly (GO:1902116)5.04476055
24patterning of blood vessels (GO:0001569)4.99414154
25negative regulation of thymocyte apoptotic process (GO:0070244)4.98284173
26motile cilium assembly (GO:0044458)4.89736214
27membrane tubulation (GO:0097320)4.67488812
28hypothalamus development (GO:0021854)4.65800801
29cellular response to interleukin-15 (GO:0071350)4.61437372
30granulocyte differentiation (GO:0030851)4.60071242
31negative regulation of phagocytosis (GO:0050765)4.56271020
32regulation of interleukin-5 production (GO:0032674)4.52414855
33negative regulation of bone remodeling (GO:0046851)4.50377592
34T-helper cell differentiation (GO:0042093)4.42601965
35CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.42601965
36response to lithium ion (GO:0010226)4.41053459
37DNA double-strand break processing (GO:0000729)4.35618469
38dentate gyrus development (GO:0021542)4.30936280
39regulation of interleukin-4 production (GO:0032673)4.24508367
40cytoplasmic mRNA processing body assembly (GO:0033962)4.19830675
41positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.10324083
42developmental pigmentation (GO:0048066)4.05040252
43coenzyme catabolic process (GO:0009109)4.03135218
44regulation of ARF GTPase activity (GO:0032312)4.01956579
45negative regulation of granulocyte differentiation (GO:0030853)4.00334969
46apoptotic process involved in morphogenesis (GO:0060561)3.96304636
47regulation of exit from mitosis (GO:0007096)3.94919551
48long term synaptic depression (GO:0060292)3.94280844
49forebrain neuron differentiation (GO:0021879)3.91178072
50lysosome localization (GO:0032418)3.89879859
51alpha-beta T cell differentiation involved in immune response (GO:0002293)3.84746936
52alpha-beta T cell activation involved in immune response (GO:0002287)3.84746936
53T cell differentiation involved in immune response (GO:0002292)3.84746936
54negative regulation of autophagy (GO:0010507)3.79414958
55negative regulation of macrophage differentiation (GO:0045650)3.78767131
56negative regulation of tissue remodeling (GO:0034104)3.77629683
57response to hydroperoxide (GO:0033194)3.74915519
58smooth muscle cell differentiation (GO:0051145)3.70104578
59anatomical structure regression (GO:0060033)3.66649145
60negative regulation of necroptotic process (GO:0060546)3.58805572
61positive regulation of B cell proliferation (GO:0030890)3.54008441
62negative regulation of metanephros development (GO:0072217)3.53252771
63CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.53087410
64telomere maintenance via semi-conservative replication (GO:0032201)3.52993043
65regulation of phosphoprotein phosphatase activity (GO:0043666)3.52015792
66lymphocyte homeostasis (GO:0002260)3.49945717
67negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.49679817
68positive regulation of protein kinase C signaling (GO:0090037)3.47061466
69response to interleukin-15 (GO:0070672)3.41132864
70B cell proliferation (GO:0042100)3.38164416
71detection of chemical stimulus involved in sensory perception (GO:0050907)3.36573974
72negative regulation of striated muscle cell apoptotic process (GO:0010664)3.35995348
73leukocyte degranulation (GO:0043299)3.34717083
74barbed-end actin filament capping (GO:0051016)3.32719130
75DNA replication initiation (GO:0006270)3.32564088
76cortical actin cytoskeleton organization (GO:0030866)3.31863490
77regulation of macrophage differentiation (GO:0045649)3.29353893
78heterochromatin organization (GO:0070828)3.28109175
79negative regulation of lymphocyte apoptotic process (GO:0070229)3.27755411
80L-fucose catabolic process (GO:0042355)3.25160299
81fucose catabolic process (GO:0019317)3.25160299
82L-fucose metabolic process (GO:0042354)3.25160299
83positive regulation of T cell migration (GO:2000406)3.23125087
84somatic stem cell division (GO:0048103)3.22198504
85cellular response to ammonium ion (GO:0071242)3.18747929
86regulation of protein kinase A signaling (GO:0010738)3.16689025
87apoptotic process involved in development (GO:1902742)3.16445802
88low-density lipoprotein particle clearance (GO:0034383)3.15797634
89C21-steroid hormone metabolic process (GO:0008207)3.15269492
90regulation of cellular extravasation (GO:0002691)3.15040819
91CD4-positive, alpha-beta T cell activation (GO:0035710)3.14326211
92modulation by host of symbiont transcription (GO:0052472)3.12629528
93modulation by host of viral transcription (GO:0043921)3.12629528
94regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.12396317
95myoblast migration (GO:0051451)3.10761778
96leukocyte homeostasis (GO:0001776)3.05117951
97cellular response to interleukin-4 (GO:0071353)3.04692166
98cellular response to epinephrine stimulus (GO:0071872)3.02279325
99positive regulation of macrophage differentiation (GO:0045651)2.93416993
100cortical cytoskeleton organization (GO:0030865)2.92717832

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human9.85310079
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse7.08751593
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.66554176
4IGF1R_20145208_ChIP-Seq_DFB_Human4.07491094
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.61664821
6AR_21572438_ChIP-Seq_LNCaP_Human2.53612801
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.47604977
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41394270
9VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.28034273
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.19380873
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.15622541
12CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.03397049
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse12.2448888
14GATA3_27048872_Chip-Seq_THYMUS_Human1.94993829
15ESR1_20079471_ChIP-ChIP_T-47D_Human1.90857253
16MYB_26560356_Chip-Seq_TH2_Human1.81380993
17ER_23166858_ChIP-Seq_MCF-7_Human1.79157887
18WDR5_24793694_ChIP-Seq_LNCAP_Human1.73030808
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.71841944
20E2F7_22180533_ChIP-Seq_HELA_Human1.67943555
21SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.66807881
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.64376202
23UTX_26944678_Chip-Seq_JUKART_Human1.62369574
24RUNX_20019798_ChIP-Seq_JUKART_Human1.61146460
25FOXM1_23109430_ChIP-Seq_U2OS_Human1.52947412
26VDR_21846776_ChIP-Seq_THP-1_Human1.50925366
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46646773
28MAF_26560356_Chip-Seq_TH2_Human1.44145323
29MYC_22102868_ChIP-Seq_BL_Human1.43262324
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.40330493
31MYB_26560356_Chip-Seq_TH1_Human1.38363115
32RXR_22108803_ChIP-Seq_LS180_Human1.35596147
33KDM2B_26808549_Chip-Seq_DND41_Human1.34090057
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33841608
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28896634
36SCL_19346495_ChIP-Seq_HPC-7_Human1.28108573
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16824361
38MAF_26560356_Chip-Seq_TH1_Human1.15847609
39VDR_24763502_ChIP-Seq_THP-1_Human1.13983443
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13497688
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05494650
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02275591
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02104752
44E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00932686
45SPI1_23127762_ChIP-Seq_K562_Human0.96969652
46CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95774847
47TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95409514
48AHR_22903824_ChIP-Seq_MCF-7_Human0.94522988
49VDR_24787735_ChIP-Seq_THP-1_Human0.93181494
50KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92579632
51EWS_26573619_Chip-Seq_HEK293_Human0.91225016
52CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87770490
53CTCF_21964334_Chip-Seq_Bcells_Human0.86795686
54CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86471752
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85418183
56PKCTHETA_26484144_Chip-Seq_BREAST_Human0.84794483
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.83573549
58ZNF274_21170338_ChIP-Seq_K562_Hela0.80721341
59CIITA_25753668_ChIP-Seq_RAJI_Human0.79352805
60ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.77713874
61BP1_19119308_ChIP-ChIP_Hs578T_Human0.77709763
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75817360
63CHD1_26751641_Chip-Seq_LNCaP_Human0.75699891
64GATA3_26560356_Chip-Seq_TH2_Human0.74910992
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.74025972
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73537989
67ARNT_22903824_ChIP-Seq_MCF-7_Human0.73186266
68RUNX1_27514584_Chip-Seq_MCF-7_Human0.72370017
69CDX2_22108803_ChIP-Seq_LS180_Human0.71541076
70CBP_21632823_ChIP-Seq_H3396_Human0.71494972
71IRF8_21731497_ChIP-ChIP_J774_Mouse0.71223127
72KDM5A_27292631_Chip-Seq_BREAST_Human0.68689003
73MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.68127751
74ESR1_15608294_ChIP-ChIP_MCF-7_Human0.66650201
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.66564445
76OCT1_27270436_Chip-Seq_PROSTATE_Human0.65973809
77LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.65213496
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63449216
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.62741333
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62644637
81TDRD3_21172665_ChIP-Seq_MCF-7_Human0.61573330
82HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.60644925
83CREB1_26743006_Chip-Seq_LNCaP_Human0.59832791
84SPI1_23547873_ChIP-Seq_NB4_Human0.59610653
85RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.59558827
86E2F4_17652178_ChIP-ChIP_JURKAT_Human0.59503427
87BRD4_25478319_ChIP-Seq_HGPS_Human0.58772322
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.57202951
89RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.55693067
90OCT4_20526341_ChIP-Seq_ESCs_Human0.55268513
91HNFA_21074721_ChIP-Seq_CACO-2_Human0.55020741
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.54932800
93ERA_21632823_ChIP-Seq_H3396_Human0.54095280
94TBL1_22424771_ChIP-Seq_293T_Human0.53054785
95KDM2B_26808549_Chip-Seq_JURKAT_Human0.52698514
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.51695494
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.51669973
98ELF5_23300383_ChIP-Seq_T47D_Human0.51637011
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.51597748
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.51421297

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004381_abnormal_hair_follicle6.67365846
2MP0003763_abnormal_thymus_physiology4.89947795
3MP0001849_ear_inflammation3.97328024
4MP0002132_abnormal_respiratory_system3.60440113
5MP0005075_abnormal_melanosome_morpholog3.30854890
6MP0000678_abnormal_parathyroid_gland3.15487815
7MP0005503_abnormal_tendon_morphology3.15066802
8MP0009840_abnormal_foam_cell2.54756520
9MP0003315_abnormal_perineum_morphology2.47210605
10MP0000703_abnormal_thymus_morphology2.47077714
11MP0010094_abnormal_chromosome_stability2.46965643
12MP0006035_abnormal_mitochondrial_morpho2.38772840
13MP0004484_altered_response_of2.36572727
14MP0000681_abnormal_thyroid_gland2.34905034
15MP0000747_muscle_weakness2.22418723
16MP0005166_decreased_susceptibility_to2.20574124
17MP0001270_distended_abdomen2.12803816
18MP0000685_abnormal_immune_system2.12199708
19MP0003136_yellow_coat_color2.11313795
20MP0010234_abnormal_vibrissa_follicle2.02916923
21MP0005499_abnormal_olfactory_system1.99831782
22MP0005394_taste/olfaction_phenotype1.99831782
23MP0002249_abnormal_larynx_morphology1.96929872
24MP0008004_abnormal_stomach_pH1.92727906
25MP0009697_abnormal_copulation1.89387353
26MP0005671_abnormal_response_to1.82103775
27MP0008789_abnormal_olfactory_epithelium1.80533145
28MP0001800_abnormal_humoral_immune1.74978943
29MP0002876_abnormal_thyroid_physiology1.71347492
30MP0003828_pulmonary_edema1.69808822
31MP0001188_hyperpigmentation1.67049917
32MP0002722_abnormal_immune_system1.64303937
33MP0005646_abnormal_pituitary_gland1.64244940
34MP0002166_altered_tumor_susceptibility1.56420819
35MP0001835_abnormal_antigen_presentation1.52808459
36MP0002405_respiratory_system_inflammati1.50970279
37MP0001529_abnormal_vocalization1.43251464
38MP0005000_abnormal_immune_tolerance1.39768409
39MP0002420_abnormal_adaptive_immunity1.38838326
40MP0009278_abnormal_bone_marrow1.36469220
41MP0001819_abnormal_immune_cell1.34760822
42MP0002398_abnormal_bone_marrow1.34142837
43MP0001944_abnormal_pancreas_morphology1.25835537
44MP0002138_abnormal_hepatobiliary_system1.22240759
45MP0002160_abnormal_reproductive_system1.21876564
46MP0002148_abnormal_hypersensitivity_rea1.21399960
47MP0000049_abnormal_middle_ear1.20891235
48MP0005387_immune_system_phenotype1.20144025
49MP0001790_abnormal_immune_system1.20144025
50MP0000716_abnormal_immune_system1.19741768
51MP0001879_abnormal_lymphatic_vessel1.18064861
52MP0002233_abnormal_nose_morphology1.13244421
53MP0003385_abnormal_body_wall1.13184223
54MP0003077_abnormal_cell_cycle1.10932533
55MP0009785_altered_susceptibility_to1.10285853
56MP0005409_darkened_coat_color1.07495989
57MP0003868_abnormal_feces_composition1.04792466
58MP0005025_abnormal_response_to1.01477824
59MP0006036_abnormal_mitochondrial_physio0.98858458
60MP0010386_abnormal_urinary_bladder0.98757958
61MP0002452_abnormal_antigen_presenting0.96654529
62MP0002108_abnormal_muscle_morphology0.95965662
63MP0000465_gastrointestinal_hemorrhage0.95952621
64MP0001544_abnormal_cardiovascular_syste0.94863360
65MP0005385_cardiovascular_system_phenoty0.94863360
66MP0006072_abnormal_retinal_apoptosis0.94545132
67MP0003935_abnormal_craniofacial_develop0.94084880
68MP0010368_abnormal_lymphatic_system0.93445750
69MP0000689_abnormal_spleen_morphology0.93112675
70MP0002092_abnormal_eye_morphology0.92782371
71MP0003693_abnormal_embryo_hatching0.91083592
72MP0001502_abnormal_circadian_rhythm0.90587566
73MP0001845_abnormal_inflammatory_respons0.88617529
74MP0002723_abnormal_immune_serum0.86709513
75MP0005464_abnormal_platelet_physiology0.86603108
76MP0003724_increased_susceptibility_to0.86117739
77MP0005174_abnormal_tail_pigmentation0.85345767
78MP0002006_tumorigenesis0.85326859
79MP0002098_abnormal_vibrissa_morphology0.84608793
80MP0008770_decreased_survivor_rate0.84585219
81MP0000477_abnormal_intestine_morphology0.82121776
82MP0000490_abnormal_crypts_of0.80825067
83MP0005187_abnormal_penis_morphology0.80314716
84MP0010155_abnormal_intestine_physiology0.80150049
85MP0001545_abnormal_hematopoietic_system0.80107184
86MP0005397_hematopoietic_system_phenotyp0.80107184
87MP0002429_abnormal_blood_cell0.78003502
88MP0000627_abnormal_mammary_gland0.77338864
89MP0002998_abnormal_bone_remodeling0.73705660
90MP0001984_abnormal_olfaction0.69461268
91MP0002127_abnormal_cardiovascular_syste0.68518947
92MP0004084_abnormal_cardiac_muscle0.68450944
93MP0003936_abnormal_reproductive_system0.66455585
94MP0009250_abnormal_appendicular_skeleto0.66218201
95MP0002419_abnormal_innate_immunity0.65373671
96MP0010630_abnormal_cardiac_muscle0.64645439
97MP0004087_abnormal_muscle_fiber0.64151962
98MP0004947_skin_inflammation0.63928143
99MP0000759_abnormal_skeletal_muscle0.62264553
100MP0000858_altered_metastatic_potential0.61937568

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the columella (HP:0009929)7.99568298
2B lymphocytopenia (HP:0010976)7.29037135
3Thyroiditis (HP:0100646)6.40697084
4Abnormality of B cell number (HP:0010975)6.39438288
5Panhypogammaglobulinemia (HP:0003139)6.30150166
6Reduced antithrombin III activity (HP:0001976)6.00890943
7Hypoplasia of the thymus (HP:0000778)5.96912673
8Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)5.93475060
9Thoracic kyphosis (HP:0002942)5.52732991
10Severe combined immunodeficiency (HP:0004430)5.36466296
11Aplasia/Hypoplasia involving the sinuses (HP:0009120)4.89594973
12Abnormality of the frontal sinuses (HP:0002687)4.86819565
13High anterior hairline (HP:0009890)4.63940452
14Eosinophilia (HP:0001880)4.49105618
15Combined immunodeficiency (HP:0005387)4.37064224
16Unsteady gait (HP:0002317)4.16287291
17Acute lymphatic leukemia (HP:0006721)3.96299146
18Lower limb hyperreflexia (HP:0002395)3.91794617
19Hypoproteinemia (HP:0003075)3.87138245
20Abnormality of the thoracic spine (HP:0100711)3.76701038
21Granulocytopenia (HP:0001913)3.73764627
22Hypothermia (HP:0002045)3.70813626
23Recurrent viral infections (HP:0004429)3.66772116
24Aplasia cutis congenita (HP:0001057)3.60572760
25T lymphocytopenia (HP:0005403)3.58786536
26Facial hemangioma (HP:0000329)3.56915759
27Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.50796667
28Thoracolumbar scoliosis (HP:0002944)3.50578890
29Recurrent fungal infections (HP:0002841)3.44057644
30Abnormality of T cell number (HP:0011839)3.16959455
31Abnormality of eosinophils (HP:0001879)3.16631281
32Abnormality of the intrinsic pathway (HP:0010989)3.09720455
33Capillary hemangiomas (HP:0005306)3.06608145
34Oligodontia (HP:0000677)3.01210307
35Median cleft lip (HP:0000161)2.96677866
36Basal ganglia calcification (HP:0002135)2.94065936
37IgG deficiency (HP:0004315)2.83696214
38Abnormality of the lumbar spine (HP:0100712)2.79629388
39Atonic seizures (HP:0010819)2.78115900
40Colitis (HP:0002583)2.77148168
41Sensory axonal neuropathy (HP:0003390)2.65902911
42Self-mutilation (HP:0000742)2.62562698
43Abnormality of the incisor (HP:0000676)2.60350314
44Protruding tongue (HP:0010808)2.52189327
45Recurrent sinusitis (HP:0011108)2.43472246
46Absent thumb (HP:0009777)2.43067571
47Benign neoplasm of the central nervous system (HP:0100835)2.41965581
48Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.36521319
49High pitched voice (HP:0001620)2.35270656
50Centrally nucleated skeletal muscle fibers (HP:0003687)2.33435991
51Carpal bone hypoplasia (HP:0001498)2.26838232
52Multiple lipomas (HP:0001012)2.25024224
53Chronic diarrhea (HP:0002028)2.22315923
54IgM deficiency (HP:0002850)2.19537511
55Erythroderma (HP:0001019)2.18623007
56Abnormality of T cells (HP:0002843)2.12001125
57Skin tags (HP:0010609)2.10228535
58Inflammation of the large intestine (HP:0002037)2.06471937
59Abnormality of the basal ganglia (HP:0002134)2.03405732
60Broad nasal tip (HP:0000455)2.03013317
61Intellectual disability, progressive (HP:0006887)2.03006835
62Squamous cell carcinoma (HP:0002860)2.02740098
63Recurrent cutaneous fungal infections (HP:0011370)2.02140573
64Chronic mucocutaneous candidiasis (HP:0002728)2.02140573
65Abnormal protein glycosylation (HP:0012346)1.95581276
66Abnormal glycosylation (HP:0012345)1.95581276
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95581276
68Abnormal protein N-linked glycosylation (HP:0012347)1.95581276
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.95278707
70Decreased activity of mitochondrial respiratory chain (HP:0008972)1.95278707
71Meningitis (HP:0001287)1.91031006
72Gastrointestinal inflammation (HP:0004386)1.90842676
73Prominent nose (HP:0000448)1.90814086
74Preauricular skin tag (HP:0000384)1.90441306
75Leukocytosis (HP:0001974)1.89031427
76Abnormality of the thymus (HP:0000777)1.88845238
77Coxa valga (HP:0002673)1.88165514
78Abnormality of the ileum (HP:0001549)1.87441867
79Aplasia/Hypoplasia of the thymus (HP:0010515)1.86709503
80Xerostomia (HP:0000217)1.81837747
81Asymmetry of the thorax (HP:0001555)1.81618821
82Thyroid-stimulating hormone excess (HP:0002925)1.80678851
83Poor head control (HP:0002421)1.80078811
84Hyporeflexia of lower limbs (HP:0002600)1.77491826
85IgA deficiency (HP:0002720)1.77426004
86Aplasia/Hypoplasia of the uvula (HP:0010293)1.76982146
87Ketosis (HP:0001946)1.75456352
88Agammaglobulinemia (HP:0004432)1.75084999
89Thickened helices (HP:0000391)1.74165496
90Popliteal pterygium (HP:0009756)1.72870712
91Meningioma (HP:0002858)1.71354912
92Abnormality of the shoulder girdle musculature (HP:0001435)1.71100771
93Abnormality of lateral ventricle (HP:0030047)1.70195267
94Small epiphyses (HP:0010585)1.68361132
95Abnormal delayed hypersensitivity skin test (HP:0002963)1.63718909
96Ureteral duplication (HP:0000073)1.63406249
97Papilledema (HP:0001085)1.60362391
98Autoimmune hemolytic anemia (HP:0001890)1.57465071
99Hypoplasia of the maxilla (HP:0000327)1.56144937
100Autoimmune thrombocytopenia (HP:0001973)1.55439081

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NLK5.69302726
2CSNK1A1L4.74128799
3CSNK1G34.51418939
4MARK34.05133820
5MAP2K73.91330177
6CSNK1G13.64440977
7CSNK1G23.57163166
8ZAP703.20877156
9NEK23.15339558
10MAP3K102.59237071
11TLK12.41092820
12FRK2.35669241
13ZAK2.24412464
14BMPR1B1.97802045
15DYRK31.90273468
16PINK11.79205905
17CDK31.72006569
18RPS6KA41.58788840
19CDK121.58277105
20ICK1.54906267
21PDGFRB1.52154397
22SGK2231.48909911
23SGK4941.48909911
24FGFR21.40676278
25MELK1.39998481
26MAP4K11.35031070
27EIF2AK31.31442149
28NME21.29445701
29PRKCQ1.21249829
30EEF2K1.15487152
31MAP3K11.11269138
32TGFBR11.10674939
33MAP3K131.10150516
34STK41.05375504
35ARAF1.03673189
36RPS6KB11.00453419
37BTK0.99839385
38CDK80.99211932
39VRK10.90777271
40SGK20.90686439
41SYK0.88148483
42WEE10.83686810
43MAP3K90.81815676
44CSNK1A10.79366072
45LATS10.74772702
46RPS6KA50.72668244
47RET0.71594984
48MAP3K50.67639344
49MTOR0.67406853
50OBSCN0.65366191
51HIPK20.63484554
52MAPK120.59982739
53MAPK110.56687783
54CSNK1D0.56577845
55CDC70.55487703
56ATM0.52555534
57GRK60.50270811
58MST1R0.49655952
59PKN20.48933061
60FES0.48381852
61MAP3K80.48172855
62CAMK40.45065001
63SGK30.45031773
64PDPK10.41945913
65TIE10.40440867
66AKT20.39534930
67MAPKAPK30.39127792
68FGFR30.38305236
69MINK10.38049826
70RPS6KA20.37134541
71DAPK30.34913689
72MOS0.33789371
73GRK10.32960858
74PAK10.31733358
75TRIB30.30300500
76AURKA0.29324862
77HCK0.28041689
78PDK10.27633462
79CDK70.24615334
80CDK140.23671975
81RPS6KC10.23165213
82RPS6KL10.23165213
83AURKB0.23042113
84CDK50.22768509
85JAK10.22101032
86DYRK20.20313999
87BLK0.19168339
88MAPKAPK50.19094810
89RPS6KA10.18968780
90IRAK20.18299596
91PRKCB0.18224444
92ADRBK20.18094178
93SIK20.17832287
94PRKAA10.17819459
95CDK90.16570129
96RPS6KA60.16546479
97MAP3K30.15995545
98MAPK90.15493493
99STK38L0.15120878
100PIK3CG0.15095367

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047404.96741932
2Phototransduction_Homo sapiens_hsa047444.52034983
3Systemic lupus erythematosus_Homo sapiens_hsa053223.89950160
4Alcoholism_Homo sapiens_hsa050343.56131703
5Renin secretion_Homo sapiens_hsa049242.55986910
6Primary immunodeficiency_Homo sapiens_hsa053402.44236475
7T cell receptor signaling pathway_Homo sapiens_hsa046602.32073386
8Glioma_Homo sapiens_hsa052142.24215331
9Oxytocin signaling pathway_Homo sapiens_hsa049212.08129305
10Thyroid cancer_Homo sapiens_hsa052162.02193212
11Endometrial cancer_Homo sapiens_hsa052131.99911060
12Salivary secretion_Homo sapiens_hsa049701.94934098
13DNA replication_Homo sapiens_hsa030301.92583255
14Melanogenesis_Homo sapiens_hsa049161.85488807
15B cell receptor signaling pathway_Homo sapiens_hsa046621.85099126
16Long-term potentiation_Homo sapiens_hsa047201.82083306
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78062662
18Gastric acid secretion_Homo sapiens_hsa049711.75386661
19cGMP-PKG signaling pathway_Homo sapiens_hsa040221.73243001
20Amphetamine addiction_Homo sapiens_hsa050311.72339621
21Circadian entrainment_Homo sapiens_hsa047131.42563071
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40807834
23Phosphatidylinositol signaling system_Homo sapiens_hsa040701.40063025
24Estrogen signaling pathway_Homo sapiens_hsa049151.36756125
25Vascular smooth muscle contraction_Homo sapiens_hsa042701.30851215
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28571154
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.26728090
28Prostate cancer_Homo sapiens_hsa052151.26700230
29Pertussis_Homo sapiens_hsa051331.25596841
30Glucagon signaling pathway_Homo sapiens_hsa049221.22440150
31GnRH signaling pathway_Homo sapiens_hsa049121.21742439
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20771712
33Oocyte meiosis_Homo sapiens_hsa041141.19493349
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14666912
35Acute myeloid leukemia_Homo sapiens_hsa052211.11898319
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11873037
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09606707
38Hepatitis B_Homo sapiens_hsa051611.09559977
39Viral carcinogenesis_Homo sapiens_hsa052031.09036525
40Hematopoietic cell lineage_Homo sapiens_hsa046401.07059986
41Calcium signaling pathway_Homo sapiens_hsa040200.99436617
42Dopaminergic synapse_Homo sapiens_hsa047280.96665344
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95672091
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91548685
45Non-small cell lung cancer_Homo sapiens_hsa052230.87006579
46Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85246224
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.84918943
48Insulin signaling pathway_Homo sapiens_hsa049100.83080639
49Wnt signaling pathway_Homo sapiens_hsa043100.79919284
50Sphingolipid signaling pathway_Homo sapiens_hsa040710.78276400
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77060874
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73940949
53Tuberculosis_Homo sapiens_hsa051520.73579357
54Circadian rhythm_Homo sapiens_hsa047100.73571314
55AMPK signaling pathway_Homo sapiens_hsa041520.68474561
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68265961
57Rap1 signaling pathway_Homo sapiens_hsa040150.67860072
58Chemical carcinogenesis_Homo sapiens_hsa052040.65056716
59Fanconi anemia pathway_Homo sapiens_hsa034600.64969421
60cAMP signaling pathway_Homo sapiens_hsa040240.64536845
61FoxO signaling pathway_Homo sapiens_hsa040680.63243596
62mTOR signaling pathway_Homo sapiens_hsa041500.59422623
63Apoptosis_Homo sapiens_hsa042100.58848823
64Ras signaling pathway_Homo sapiens_hsa040140.58820335
65PPAR signaling pathway_Homo sapiens_hsa033200.58268235
66Melanoma_Homo sapiens_hsa052180.57135956
67TGF-beta signaling pathway_Homo sapiens_hsa043500.56638891
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55944495
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53298481
70Colorectal cancer_Homo sapiens_hsa052100.53081279
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.52195491
72Herpes simplex infection_Homo sapiens_hsa051680.51550992
73Pyrimidine metabolism_Homo sapiens_hsa002400.51326190
74Basal cell carcinoma_Homo sapiens_hsa052170.50900105
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47456579
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44157055
77Hedgehog signaling pathway_Homo sapiens_hsa043400.43084348
78Measles_Homo sapiens_hsa051620.42908430
79Taste transduction_Homo sapiens_hsa047420.41171048
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39789322
81Hepatitis C_Homo sapiens_hsa051600.38056802
82Adherens junction_Homo sapiens_hsa045200.37012118
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36527342
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36487269
85HTLV-I infection_Homo sapiens_hsa051660.36403790
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36043454
87beta-Alanine metabolism_Homo sapiens_hsa004100.34446773
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33325801
89Arachidonic acid metabolism_Homo sapiens_hsa005900.31814082
90Graft-versus-host disease_Homo sapiens_hsa053320.30392283
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28655183
92Cholinergic synapse_Homo sapiens_hsa047250.28171436
93Autoimmune thyroid disease_Homo sapiens_hsa053200.27589221
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26065229
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23489313
96Antigen processing and presentation_Homo sapiens_hsa046120.23216520
97MAPK signaling pathway_Homo sapiens_hsa040100.23106202
98Hippo signaling pathway_Homo sapiens_hsa043900.22274077
99Choline metabolism in cancer_Homo sapiens_hsa052310.22270028
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.20574672

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