ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore complex assembly (GO:0051292)	5.11961632
2	nuclear pore organization (GO:0006999)	4.77457410
3	regulation of hippo signaling (GO:0035330)	4.36932798
4	regulation of translational fidelity (GO:0006450)	4.15701826
5	pore complex assembly (GO:0046931)	3.82316175
6	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.65117609
7	regulation of centrosome duplication (GO:0010824)	3.63296757
8	regulation of centrosome cycle (GO:0046605)	3.55039738
9	regulation of centriole replication (GO:0046599)	3.37424021
10	mitotic sister chromatid segregation (GO:0000070)	3.27610954
11	mitotic sister chromatid cohesion (GO:0007064)	3.16894931
12	mitotic chromosome condensation (GO:0007076)	3.16785251
13	sister chromatid segregation (GO:0000819)	3.16002751
14	DNA replication initiation (GO:0006270)	3.11095203
15	meiotic chromosome segregation (GO:0045132)	3.10211532
16	iron ion import (GO:0097286)	3.04022273
17	mRNA cleavage (GO:0006379)	2.98780434
18	ribosome assembly (GO:0042255)	2.98203215
19	DNA replication checkpoint (GO:0000076)	2.84711394
20	proline biosynthetic process (GO:0006561)	2.83362780
21	ribosome biogenesis (GO:0042254)	2.81482351
22	DNA duplex unwinding (GO:0032508)	2.80692193
23	regulation of translational elongation (GO:0006448)	2.77205003
24	DNA geometric change (GO:0032392)	2.75286459
25	folic acid-containing compound biosynthetic process (GO:0009396)	2.73770829
26	biotin metabolic process (GO:0006768)	2.73179051
27	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.72969107
28	monoubiquitinated protein deubiquitination (GO:0035520)	2.69198255
29	DNA strand elongation (GO:0022616)	2.65017018
30	DNA strand elongation involved in DNA replication (GO:0006271)	2.63765502
31	mitochondrial RNA metabolic process (GO:0000959)	2.63588483
32	nucleobase-containing small molecule interconversion (GO:0015949)	2.59173561
33	mitotic nuclear envelope disassembly (GO:0007077)	2.57342838
34	rRNA methylation (GO:0031167)	2.56639790
35	sister chromatid cohesion (GO:0007062)	2.56317968
36	folic acid metabolic process (GO:0046655)	2.55683100
37	gonadal mesoderm development (GO:0007506)	2.55531927
38	nucleotide-sugar biosynthetic process (GO:0009226)	2.55001833
39	aspartate family amino acid biosynthetic process (GO:0009067)	2.54836669
40	TOR signaling (GO:0031929)	2.52250129
41	methionine biosynthetic process (GO:0009086)	2.52223333
42	rRNA modification (GO:0000154)	2.51849352
43	binding of sperm to zona pellucida (GO:0007339)	2.51842539
44	folic acid-containing compound metabolic process (GO:0006760)	2.51824537
45	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.48098023
46	tRNA aminoacylation (GO:0043039)	2.47729170
47	amino acid activation (GO:0043038)	2.47729170
48	regulation of sister chromatid cohesion (GO:0007063)	2.47587409
49	telomere maintenance via semi-conservative replication (GO:0032201)	2.47070674
50	tRNA aminoacylation for protein translation (GO:0006418)	2.46410552
51	centrosome duplication (GO:0051298)	2.44672102
52	sulfur amino acid biosynthetic process (GO:0000097)	2.43898830
53	tetrahydrofolate metabolic process (GO:0046653)	2.43743552
54	replication fork processing (GO:0031297)	2.43512223
55	peptidyl-lysine dimethylation (GO:0018027)	2.42808146
56	DNA-dependent DNA replication (GO:0006261)	2.41382979
57	DNA unwinding involved in DNA replication (GO:0006268)	2.39821660
58	regulation of mitotic spindle organization (GO:0060236)	2.39617267
59	regulation of mitochondrial translation (GO:0070129)	2.39319388
60	ribonucleoprotein complex biogenesis (GO:0022613)	2.36911957
61	pteridine-containing compound metabolic process (GO:0042558)	2.36760030
62	negative regulation of sodium ion transport (GO:0010766)	2.35962687
63	DNA conformation change (GO:0071103)	2.35724699
64	COPII vesicle coating (GO:0048208)	2.35435947
65	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.34955623
66	zinc ion transmembrane transport (GO:0071577)	2.32926091
67	protein localization to chromosome, centromeric region (GO:0071459)	2.31209329
68	telomere maintenance via recombination (GO:0000722)	2.27855749
69	mitochondrial DNA replication (GO:0006264)	2.26370988
70	gene silencing by RNA (GO:0031047)	2.26323904
71	regulation of establishment of cell polarity (GO:2000114)	2.26300807
72	pseudouridine synthesis (GO:0001522)	2.25862678
73	chromosome condensation (GO:0030261)	2.25217539
74	membrane disassembly (GO:0030397)	2.24938499
75	nuclear envelope disassembly (GO:0051081)	2.24938499
76	pteridine-containing compound biosynthetic process (GO:0042559)	2.24683815
77	chromosome organization involved in meiosis (GO:0070192)	2.24117847
78	nucleotide-sugar metabolic process (GO:0009225)	2.23327178
79	positive regulation of cell cycle checkpoint (GO:1901978)	2.23247689
80	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.23217146
81	translesion synthesis (GO:0019985)	2.20999574
82	DNA replication-dependent nucleosome organization (GO:0034723)	2.20888559
83	DNA replication-dependent nucleosome assembly (GO:0006335)	2.20888559
84	protein localization to kinetochore (GO:0034501)	2.20707314
85	mitotic cytokinesis (GO:0000281)	2.19434547
86	rRNA transcription (GO:0009303)	2.18128442
87	sperm-egg recognition (GO:0035036)	2.17860185
88	mitochondrial DNA metabolic process (GO:0032042)	2.17347912
89	double-strand break repair via homologous recombination (GO:0000724)	2.17339281
90	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.15548353
91	mitotic recombination (GO:0006312)	2.15184104
92	recombinational repair (GO:0000725)	2.15054097
93	tRNA methylation (GO:0030488)	2.14901627
94	melanin biosynthetic process (GO:0042438)	2.14570003
95	amino acid salvage (GO:0043102)	2.14272819
96	L-methionine salvage (GO:0071267)	2.14272819
97	L-methionine biosynthetic process (GO:0071265)	2.14272819
98	kinetochore organization (GO:0051383)	2.14215053
99	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.12936981
100	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	2.12788460

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.06318539
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.78967874
3	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.65242396
4	AR_21909140_ChIP-Seq_LNCAP_Human	3.60055207
5	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.09483505
6	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.99870686
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.95361688
8	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.77930328
9	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.69109954
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.55258280
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.43986989
12	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.43050228
13	ZNF263_19887448_ChIP-Seq_K562_Human	2.43043839
14	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.40202159
15	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.28470103
16	PADI4_21655091_ChIP-ChIP_MCF-7_Human	2.18398936
17	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.18248240
18	DCP1A_22483619_ChIP-Seq_HELA_Human	2.15443720
19	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.14833914
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.12481027
21	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.04954438
22	KDM5A_27292631_Chip-Seq_BREAST_Human	2.04096259
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.93888422
24	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.90373709
25	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.82919153
26	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.75980857
27	GABP_19822575_ChIP-Seq_HepG2_Human	1.72579312
28	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.71680000
29	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.70567474
30	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.68194387
31	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.68029834
32	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.67085905
33	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.66831059
34	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.63763514
35	XRN2_22483619_ChIP-Seq_HELA_Human	1.57250056
36	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.56723446
37	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.54596510
38	ER_23166858_ChIP-Seq_MCF-7_Human	1.53418074
39	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.49632714
40	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.48876766
41	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.46300511
42	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.46095354
43	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.44366153
44	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.41898877
45	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.38992874
46	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.36484444
47	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.35497307
48	TTF2_22483619_ChIP-Seq_HELA_Human	1.33625153
49	CHD1_26751641_Chip-Seq_LNCaP_Human	1.33357065
50	VDR_23849224_ChIP-Seq_CD4+_Human	1.32397695
51	VDR_22108803_ChIP-Seq_LS180_Human	1.32197719
52	ZNF274_21170338_ChIP-Seq_K562_Hela	1.31369638
53	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.28818054
54	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.27027213
55	GATA6_25053715_ChIP-Seq_YYC3_Human	1.26135835
56	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.24438016
57	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.22675139
58	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.22513097
59	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.22513097
60	FUS_26573619_Chip-Seq_HEK293_Human	1.22039316
61	EWS_26573619_Chip-Seq_HEK293_Human	1.21938357
62	TFEB_21752829_ChIP-Seq_HELA_Human	1.20209763
63	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.19526388
64	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.18506721
65	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.17215315
66	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.16956512
67	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.15506386
68	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.14412834
69	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.14370188
70	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.12925429
71	MYC_18940864_ChIP-ChIP_HL60_Human	1.11745410
72	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.11701317
73	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.11619252
74	AHR_22903824_ChIP-Seq_MCF-7_Human	1.09497861
75	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.07403792
76	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.06315957
77	ELF5_23300383_ChIP-Seq_T47D_Human	1.06126881
78	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.05232009
79	FOXP3_21729870_ChIP-Seq_TREG_Human	1.04748175
80	IGF1R_20145208_ChIP-Seq_DFB_Human	1.04171669
81	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.03044584
82	AR_21572438_ChIP-Seq_LNCaP_Human	1.02606073
83	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.02050923
84	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.01800418
85	BRD4_25478319_ChIP-Seq_HGPS_Human	1.00282932
86	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98572966
87	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.98182203
88	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.97213217
89	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	0.96430386
90	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.94458577
91	ATF3_27146783_Chip-Seq_COLON_Human	0.94175157
92	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.93078065
93	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.92290283
94	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.91138538
95	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.90808974
96	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.90793013
97	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.90130754
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.86357548
99	CJUN_26792858_Chip-Seq_BT549_Human	0.86342537
100	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.85587918

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	3.62518232
2	MP0010094_abnormal_chromosome_stability	3.14792262
3	MP0005408_hypopigmentation	2.63795713
4	MP0004233_abnormal_muscle_weight	2.45313028
5	MP0002160_abnormal_reproductive_system	2.31251888
6	MP0005171_absent_coat_pigmentation	2.29011115
7	MP0003111_abnormal_nucleus_morphology	2.27542839
8	MP0003693_abnormal_embryo_hatching	2.26494852
9	MP0003077_abnormal_cell_cycle	2.24369215
10	MP0008058_abnormal_DNA_repair	2.12205545
11	MP0002877_abnormal_melanocyte_morpholog	2.11228216
12	MP0003950_abnormal_plasma_membrane	2.04111505
13	MP0003806_abnormal_nucleotide_metabolis	2.02371270
14	MP0001661_extended_life_span	1.93527129
15	MP0009697_abnormal_copulation	1.88797243
16	MP0003136_yellow_coat_color	1.82064824
17	MP0009780_abnormal_chondrocyte_physiolo	1.81218167
18	MP0000372_irregular_coat_pigmentation	1.79890925
19	MP0004957_abnormal_blastocyst_morpholog	1.76685659
20	MP0008007_abnormal_cellular_replicative	1.75239952
21	MP0002009_preneoplasia	1.73683945
22	MP0003718_maternal_effect	1.66907020
23	MP0008438_abnormal_cutaneous_collagen	1.54957784
24	MP0008932_abnormal_embryonic_tissue	1.53202815
25	MP0003315_abnormal_perineum_morphology	1.51213110
26	MP0004272_abnormal_basement_membrane	1.44493645
27	MP0005410_abnormal_fertilization	1.40911406
28	MP0002938_white_spotting	1.39219764
29	MP0000427_abnormal_hair_cycle	1.36256236
30	MP0005360_urolithiasis	1.29567692
31	MP0003786_premature_aging	1.28728782
32	MP0003937_abnormal_limbs/digits/tail_de	1.27930755
33	MP0005076_abnormal_cell_differentiation	1.27111999
34	MP0010307_abnormal_tumor_latency	1.23997795
35	MP0005187_abnormal_penis_morphology	1.22559795
36	MP0010234_abnormal_vibrissa_follicle	1.21508239
37	MP0000569_abnormal_digit_pigmentation	1.21419422
38	MP0000371_diluted_coat_color	1.20195573
39	MP0001672_abnormal_embryogenesis/_devel	1.19448005
40	MP0005380_embryogenesis_phenotype	1.19448005
41	MP0000538_abnormal_urinary_bladder	1.18528906
42	MP0002088_abnormal_embryonic_growth/wei	1.17375523
43	MP0003984_embryonic_growth_retardation	1.17351898
44	MP0000537_abnormal_urethra_morphology	1.17053354
45	MP0005389_reproductive_system_phenotype	1.14597864
46	MP0000627_abnormal_mammary_gland	1.10762595
47	MP0001697_abnormal_embryo_size	1.08828519
48	MP0005503_abnormal_tendon_morphology	1.07284818
49	MP0000358_abnormal_cell_content/	1.05279503
50	MP0000350_abnormal_cell_proliferation	1.03799008
51	MP0010352_gastrointestinal_tract_polyps	1.02498815
52	MP0010678_abnormal_skin_adnexa	1.02008073
53	MP0004197_abnormal_fetal_growth/weight/	1.01501010
54	MP0002084_abnormal_developmental_patter	1.00178991
55	MP0001270_distended_abdomen	1.00149649
56	MP0000383_abnormal_hair_follicle	0.99454795
57	MP0004264_abnormal_extraembryonic_tissu	0.98684297
58	MP0003943_abnormal_hepatobiliary_system	0.98576807
59	MP0005395_other_phenotype	0.97627930
60	MP0001929_abnormal_gametogenesis	0.97535954
61	MP0005646_abnormal_pituitary_gland	0.96246225
62	MP0003385_abnormal_body_wall	0.94114782
63	MP0002086_abnormal_extraembryonic_tissu	0.93513126
64	MP0005409_darkened_coat_color	0.92759991
65	MP0003942_abnormal_urinary_system	0.91509320
66	MP0005174_abnormal_tail_pigmentation	0.91360674
67	MP0002210_abnormal_sex_determination	0.91068920
68	MP0002075_abnormal_coat/hair_pigmentati	0.90445097
69	MP0002108_abnormal_muscle_morphology	0.89791009
70	MP0000003_abnormal_adipose_tissue	0.88266792
71	MP0002060_abnormal_skin_morphology	0.88175517
72	MP0004782_abnormal_surfactant_physiolog	0.86726413
73	MP0001186_pigmentation_phenotype	0.86477325
74	MP0002080_prenatal_lethality	0.86271681
75	MP0000762_abnormal_tongue_morphology	0.85838619
76	MP0003936_abnormal_reproductive_system	0.84441052
77	MP0003252_abnormal_bile_duct	0.83479788
78	MP0002269_muscular_atrophy	0.83398839
79	MP0009250_abnormal_appendicular_skeleto	0.82792020
80	MP0003698_abnormal_male_reproductive	0.81953944
81	MP0003705_abnormal_hypodermis_morpholog	0.81666028
82	MP0001873_stomach_inflammation	0.81564789
83	MP0000653_abnormal_sex_gland	0.79339069
84	MP0002234_abnormal_pharynx_morphology	0.78564293
85	MP0003935_abnormal_craniofacial_develop	0.78530126
86	MP0001730_embryonic_growth_arrest	0.78230801
87	MP0002697_abnormal_eye_size	0.78133041
88	MP0002085_abnormal_embryonic_tissue	0.77265397
89	MP0001145_abnormal_male_reproductive	0.76955810
90	MP0003755_abnormal_palate_morphology	0.76860945
91	MP0002098_abnormal_vibrissa_morphology	0.76212932
92	MP0001919_abnormal_reproductive_system	0.76208917
93	MP0003123_paternal_imprinting	0.74515699
94	MP0000013_abnormal_adipose_tissue	0.74386403
95	MP0000733_abnormal_muscle_development	0.71921081
96	MP0003115_abnormal_respiratory_system	0.70938955
97	MP0001299_abnormal_eye_distance/	0.70881430
98	MP0000534_abnormal_ureter_morphology	0.70811759
99	MP0005647_abnormal_sex_gland	0.70418434
100	MP0006138_congestive_heart_failure	0.70314494

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromsome breakage (HP:0040012)	4.85642034
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.81077438
3	Asymmetry of the thorax (HP:0001555)	3.15546831
4	Abnormality of the preputium (HP:0100587)	2.93473903
5	Abnormality of the intrinsic pathway (HP:0010989)	2.89053848
6	Meckel diverticulum (HP:0002245)	2.87913871
7	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.85378016
8	Abnormality of the ileum (HP:0001549)	2.84897463
9	Birth length less than 3rd percentile (HP:0003561)	2.82266654
10	Abnormality of chromosome stability (HP:0003220)	2.67932901
11	Abnormality of the carotid arteries (HP:0005344)	2.62973341
12	Cerebellar dysplasia (HP:0007033)	2.58179239
13	Hypopigmentation of the fundus (HP:0007894)	2.57861174
14	Fibular aplasia (HP:0002990)	2.54907291
15	Small epiphyses (HP:0010585)	2.52658856
16	Cutaneous melanoma (HP:0012056)	2.48039711
17	Absent radius (HP:0003974)	2.35655391
18	Capillary hemangiomas (HP:0005306)	2.26401696
19	Reduced antithrombin III activity (HP:0001976)	2.25438981
20	Septate vagina (HP:0001153)	2.22754250
21	Clubbing of toes (HP:0100760)	2.22027558
22	Poikiloderma (HP:0001029)	2.20725671
23	Absent forearm bone (HP:0003953)	2.20452116
24	Aplasia involving forearm bones (HP:0009822)	2.20452116
25	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.18126209
26	Abnormality of the astrocytes (HP:0100707)	2.15852863
27	Astrocytoma (HP:0009592)	2.15852863
28	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.15306618
29	Short thumb (HP:0009778)	2.10409572
30	Hamartoma of the eye (HP:0010568)	2.08899015
31	Ependymoma (HP:0002888)	2.08017477
32	Lip pit (HP:0100267)	2.07968487
33	Breast hypoplasia (HP:0003187)	2.05158595
34	Concave nail (HP:0001598)	2.02533650
35	Sloping forehead (HP:0000340)	2.01906612
36	Enlarged kidneys (HP:0000105)	1.98846484
37	Short chin (HP:0000331)	1.97688293
38	Meningioma (HP:0002858)	1.97619892
39	Abnormality of the nasal septum (HP:0000419)	1.97176754
40	Type II lissencephaly (HP:0007260)	1.96326746
41	Abnormality of alanine metabolism (HP:0010916)	1.94575155
42	Hyperalaninemia (HP:0003348)	1.94575155
43	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.94575155
44	Pheochromocytoma (HP:0002666)	1.93303064
45	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.93225255
46	Microglossia (HP:0000171)	1.93063899
47	Sensory axonal neuropathy (HP:0003390)	1.92760006
48	Glioma (HP:0009733)	1.92457021
49	Deviation of the thumb (HP:0009603)	1.92068586
50	Dysmetric saccades (HP:0000641)	1.89436546
51	Squamous cell carcinoma (HP:0002860)	1.86708174
52	Duplicated collecting system (HP:0000081)	1.86570487
53	Volvulus (HP:0002580)	1.82287856
54	Proximal placement of thumb (HP:0009623)	1.81990996
55	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.77392451
56	Abnormal protein N-linked glycosylation (HP:0012347)	1.77392451
57	Abnormal protein glycosylation (HP:0012346)	1.77392451
58	Abnormal glycosylation (HP:0012345)	1.77392451
59	Type I transferrin isoform profile (HP:0003642)	1.76918076
60	Hypoplasia of the pons (HP:0012110)	1.76525477
61	Clumsiness (HP:0002312)	1.76185591
62	Patellar aplasia (HP:0006443)	1.75466670
63	Absent thumb (HP:0009777)	1.75323286
64	Ectopic kidney (HP:0000086)	1.74769434
65	Duodenal stenosis (HP:0100867)	1.74325237
66	Small intestinal stenosis (HP:0012848)	1.74325237
67	Increased nuchal translucency (HP:0010880)	1.73394021
68	Deep philtrum (HP:0002002)	1.72268113
69	Abnormality of DNA repair (HP:0003254)	1.72022903
70	Aplasia/Hypoplasia of the patella (HP:0006498)	1.71709712
71	Entropion (HP:0000621)	1.70423016
72	Facial hemangioma (HP:0000329)	1.70304812
73	Myelodysplasia (HP:0002863)	1.70288956
74	Aplasia cutis congenita (HP:0001057)	1.69862789
75	Mitral stenosis (HP:0001718)	1.69600040
76	Abnormality of the pons (HP:0007361)	1.68571187
77	Cafe-au-lait spot (HP:0000957)	1.67561717
78	Flat acetabular roof (HP:0003180)	1.67309320
79	Self-mutilation (HP:0000742)	1.66444706
80	Absent epiphyses (HP:0010577)	1.66232405
81	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.66232405
82	Pancreatic cysts (HP:0001737)	1.65651201
83	High pitched voice (HP:0001620)	1.62903602
84	Abnormality of the renal collecting system (HP:0004742)	1.62826561
85	Renovascular hypertension (HP:0100817)	1.62707383
86	Underdeveloped nasal alae (HP:0000430)	1.61240480
87	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.61181161
88	Arteriovenous malformation (HP:0100026)	1.61021962
89	Sparse lateral eyebrow (HP:0005338)	1.60894554
90	Hyperacusis (HP:0010780)	1.57863782
91	Microretrognathia (HP:0000308)	1.57707163
92	Renal cortical cysts (HP:0000803)	1.57338170
93	Fibular hypoplasia (HP:0003038)	1.57258068
94	Aplasia/hypoplasia of the humerus (HP:0006507)	1.55984517
95	Neuroendocrine neoplasm (HP:0100634)	1.55804148
96	Neoplasm of the peripheral nervous system (HP:0100007)	1.55650092
97	Hypobetalipoproteinemia (HP:0003563)	1.54362556
98	Oligodontia (HP:0000677)	1.54004284
99	Short humerus (HP:0005792)	1.53766642
100	Melanoma (HP:0002861)	1.53675429

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.67963852
2	EIF2AK1	3.04593426
3	PBK	2.94204727
4	MST1R	2.76437526
5	LATS1	2.74638255
6	TLK1	2.60396827
7	ZAK	2.51190417
8	BMPR1B	2.26711803
9	SCYL2	2.26390523
10	IRAK3	2.25753378
11	NME2	2.24985294
12	AKT3	2.18281339
13	EEF2K	2.15594854
14	EIF2AK3	2.08502127
15	MET	1.99243448
16	TRIB3	1.95794683
17	NEK2	1.82594010
18	WEE1	1.79550742
19	BRSK2	1.77654062
20	EPHA2	1.77343066
21	ICK	1.71983757
22	SRPK1	1.68762286
23	CDK12	1.66035143
24	NEK1	1.55570560
25	BUB1	1.54129489
26	CDK8	1.47921623
27	CHEK2	1.36594672
28	WNK4	1.34972966
29	RPS6KB2	1.33847055
30	MAPKAPK3	1.28907189
31	STK38L	1.27304302
32	TTK	1.18492571
33	PRKD3	1.17543445
34	STK39	1.16633430
35	CDK7	1.16349152
36	PINK1	1.05795885
37	CDC7	1.01757088
38	STK3	1.01701982
39	PKN2	0.99971008
40	PTK2	0.98757828
41	TSSK6	0.98717121
42	ACVR1B	0.98376103
43	MARK3	0.98242772
44	ILK	0.97588419
45	ATR	0.97422036
46	PIK3CA	0.96074673
47	AURKB	0.95839693
48	PLK1	0.92600652
49	ERBB3	0.92447858
50	TRPM7	0.92180082
51	PDGFRA	0.91129198
52	MTOR	0.91101130
53	LATS2	0.90202416
54	PAK2	0.86779026
55	ERBB4	0.85342722
56	BRSK1	0.83332832
57	MUSK	0.82372878
58	ATM	0.80956426
59	MELK	0.80949394
60	CHEK1	0.71962524
61	MAP3K2	0.71624788
62	TGFBR1	0.68552360
63	FER	0.66236324
64	MAPK11	0.66072480
65	PNCK	0.64328967
66	STK38	0.64000270
67	AURKA	0.63312968
68	PAK4	0.63262731
69	CSNK1A1L	0.61998348
70	MYLK	0.61990948
71	PRKCI	0.60689894
72	CCNB1	0.60090914
73	GRK1	0.59577781
74	AKT2	0.59366495
75	RPS6KB1	0.57923252
76	CDK1	0.57097131
77	NEK6	0.54667632
78	PLK4	0.53847044
79	TRIM28	0.52338074
80	INSRR	0.52103281
81	MAP2K1	0.51986498
82	CAMK1G	0.51679770
83	PLK3	0.49449711
84	MAPKAPK5	0.48827390
85	PDK2	0.48719836
86	CAMK1D	0.48603534
87	RPS6KA5	0.48228629
88	EIF2AK2	0.43518987
89	CSNK1E	0.42244489
90	CDK4	0.39638438
91	CDK2	0.38631919
92	PDGFRB	0.38039995
93	BRD4	0.37444287
94	RET	0.36864826
95	SIK1	0.36602607
96	PRKAA2	0.36548452
97	CDK3	0.35585552
98	FLT3	0.35160799
99	PRKAA1	0.34156193
100	MKNK2	0.33008704

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.18505219
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.11504422
3	One carbon pool by folate_Homo sapiens_hsa00670	2.78831723
4	DNA replication_Homo sapiens_hsa03030	2.62185793
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.59420259
6	Homologous recombination_Homo sapiens_hsa03440	2.56014660
7	Non-homologous end-joining_Homo sapiens_hsa03450	2.40381264
8	Nucleotide excision repair_Homo sapiens_hsa03420	2.14284358
9	RNA polymerase_Homo sapiens_hsa03020	2.12469638
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.12129079
11	RNA transport_Homo sapiens_hsa03013	2.06226371
12	Mismatch repair_Homo sapiens_hsa03430	1.94156087
13	Pyrimidine metabolism_Homo sapiens_hsa00240	1.80103631
14	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.79587075
15	Cell cycle_Homo sapiens_hsa04110	1.75823758
16	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.73588318
17	Basal transcription factors_Homo sapiens_hsa03022	1.71750570
18	Sulfur relay system_Homo sapiens_hsa04122	1.67959194
19	Lysine degradation_Homo sapiens_hsa00310	1.67009996
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.47559651
21	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.47450728
22	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.46274749
23	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.42516910
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.39853385
25	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.35872692
26	Base excision repair_Homo sapiens_hsa03410	1.33361796
27	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.32466433
28	ABC transporters_Homo sapiens_hsa02010	1.25995551
29	p53 signaling pathway_Homo sapiens_hsa04115	1.19386347
30	Pyruvate metabolism_Homo sapiens_hsa00620	1.14084362
31	mRNA surveillance pathway_Homo sapiens_hsa03015	1.12275549
32	Purine metabolism_Homo sapiens_hsa00230	1.11833659
33	RNA degradation_Homo sapiens_hsa03018	1.09406789
34	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.08493848
35	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.05136166
36	Arginine biosynthesis_Homo sapiens_hsa00220	1.00948189
37	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.00579059
38	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.97129147
39	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.96492843
40	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.93414020
41	Propanoate metabolism_Homo sapiens_hsa00640	0.91378420
42	Small cell lung cancer_Homo sapiens_hsa05222	0.91192846
43	Spliceosome_Homo sapiens_hsa03040	0.90192016
44	Nitrogen metabolism_Homo sapiens_hsa00910	0.89535315
45	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.89308444
46	Sulfur metabolism_Homo sapiens_hsa00920	0.88462233
47	Arginine and proline metabolism_Homo sapiens_hsa00330	0.88135486
48	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87309545
49	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.87074188
50	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.86360763
51	Alcoholism_Homo sapiens_hsa05034	0.85265871
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.84842853
53	Hippo signaling pathway_Homo sapiens_hsa04390	0.81644547
54	Ribosome_Homo sapiens_hsa03010	0.80876548
55	Sphingolipid metabolism_Homo sapiens_hsa00600	0.79805388
56	ECM-receptor interaction_Homo sapiens_hsa04512	0.78210875
57	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.77292821
58	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.76338633
59	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.75332259
60	Circadian rhythm_Homo sapiens_hsa04710	0.74807894
61	Melanoma_Homo sapiens_hsa05218	0.74272946
62	Fatty acid metabolism_Homo sapiens_hsa01212	0.73508245
63	Tyrosine metabolism_Homo sapiens_hsa00350	0.72886798
64	Proteasome_Homo sapiens_hsa03050	0.71580932
65	Butanoate metabolism_Homo sapiens_hsa00650	0.70905209
66	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.68860674
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.66202256
68	Glutathione metabolism_Homo sapiens_hsa00480	0.65660696
69	mTOR signaling pathway_Homo sapiens_hsa04150	0.63507944
70	Histidine metabolism_Homo sapiens_hsa00340	0.62646430
71	Tryptophan metabolism_Homo sapiens_hsa00380	0.62392004
72	Oocyte meiosis_Homo sapiens_hsa04114	0.61182399
73	Metabolic pathways_Homo sapiens_hsa01100	0.60176032
74	Thyroid cancer_Homo sapiens_hsa05216	0.60022633
75	Protein export_Homo sapiens_hsa03060	0.57395490
76	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.56730694
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.54260365
78	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.54250404
79	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.52853282
80	Bladder cancer_Homo sapiens_hsa05219	0.51332480
81	Folate biosynthesis_Homo sapiens_hsa00790	0.50287181
82	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.50237063
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.48330820
84	MicroRNAs in cancer_Homo sapiens_hsa05206	0.48320563
85	Steroid biosynthesis_Homo sapiens_hsa00100	0.47864416
86	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.46245080
87	Mineral absorption_Homo sapiens_hsa04978	0.45330337
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43224375
89	Prostate cancer_Homo sapiens_hsa05215	0.42540305
90	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.40480334
91	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.39444911
92	Glycerolipid metabolism_Homo sapiens_hsa00561	0.39277398
93	Glioma_Homo sapiens_hsa05214	0.37473035
94	Viral carcinogenesis_Homo sapiens_hsa05203	0.36896849
95	AMPK signaling pathway_Homo sapiens_hsa04152	0.36129635
96	Phenylalanine metabolism_Homo sapiens_hsa00360	0.36101258
97	Complement and coagulation cascades_Homo sapiens_hsa04610	0.35342372
98	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.34552076
99	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.34285285
100	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.33711981

LINC01296

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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