ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein K11-linked deubiquitination (GO:0035871)	4.60978650
2	tryptophan catabolic process (GO:0006569)	3.98447829
3	indole-containing compound catabolic process (GO:0042436)	3.98447829
4	indolalkylamine catabolic process (GO:0046218)	3.98447829
5	exogenous drug catabolic process (GO:0042738)	3.68436181
6	aromatic amino acid family catabolic process (GO:0009074)	3.62774044
7	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.60131383
8	cellular ketone body metabolic process (GO:0046950)	3.59061963
9	postsynaptic membrane organization (GO:0001941)	3.56721765
10	gamma-aminobutyric acid transport (GO:0015812)	3.55175597
11	dicarboxylic acid biosynthetic process (GO:0043650)	3.43693850
12	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	3.42536828
13	omega-hydroxylase P450 pathway (GO:0097267)	3.38091816
14	axon ensheathment in central nervous system (GO:0032291)	3.37800133
15	central nervous system myelination (GO:0022010)	3.37800133
16	locomotory exploration behavior (GO:0035641)	3.32670316
17	synaptic vesicle maturation (GO:0016188)	3.31992791
18	drug catabolic process (GO:0042737)	3.30891227
19	sex differentiation (GO:0007548)	3.27010944
20	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.22641036
21	L-phenylalanine catabolic process (GO:0006559)	3.22641036
22	auditory behavior (GO:0031223)	3.22122947
23	ketone body metabolic process (GO:1902224)	3.21224808
24	neuronal action potential propagation (GO:0019227)	3.21120784
25	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.19586943
26	C4-dicarboxylate transport (GO:0015740)	3.17570433
27	bile acid biosynthetic process (GO:0006699)	3.13859355
28	glycerophospholipid catabolic process (GO:0046475)	3.12630249
29	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.11677808
30	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.10190034
31	righting reflex (GO:0060013)	3.09871136
32	regulation of memory T cell differentiation (GO:0043380)	3.06217092
33	tryptophan metabolic process (GO:0006568)	3.02128377
34	serotonin receptor signaling pathway (GO:0007210)	2.99095285
35	proline transport (GO:0015824)	2.93393494
36	startle response (GO:0001964)	2.93129687
37	cholesterol catabolic process (GO:0006707)	2.90669123
38	sterol catabolic process (GO:0016127)	2.90669123
39	negative regulation of multicellular organism growth (GO:0040015)	2.90552265
40	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.87738559
41	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.84884410
42	mechanosensory behavior (GO:0007638)	2.79305441
43	serine family amino acid catabolic process (GO:0009071)	2.78932541
44	sulfation (GO:0051923)	2.78500557
45	neurotransmitter uptake (GO:0001504)	2.77888447
46	presynaptic membrane assembly (GO:0097105)	2.77628197
47	neuron cell-cell adhesion (GO:0007158)	2.77346627
48	auditory receptor cell stereocilium organization (GO:0060088)	2.75734022
49	regulation of action potential (GO:0098900)	2.73657837
50	alanine transport (GO:0032328)	2.73641297
51	synaptic transmission, glutamatergic (GO:0035249)	2.73230902
52	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.72258685
53	neurotransmitter-gated ion channel clustering (GO:0072578)	2.71947868
54	amino-acid betaine metabolic process (GO:0006577)	2.70896866
55	presynaptic membrane organization (GO:0097090)	2.67198162
56	positive regulation of vasculogenesis (GO:2001214)	2.65973674
57	androgen biosynthetic process (GO:0006702)	2.65593402
58	kynurenine metabolic process (GO:0070189)	2.64809744
59	NAD biosynthetic process (GO:0009435)	2.62993295
60	flavonoid metabolic process (GO:0009812)	2.62790512
61	lipid translocation (GO:0034204)	2.62491590
62	phospholipid translocation (GO:0045332)	2.62491590
63	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.62313718
64	cysteine metabolic process (GO:0006534)	2.60113093
65	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.60022306
66	organic cation transport (GO:0015695)	2.57124160
67	behavioral response to nicotine (GO:0035095)	2.56525723
68	potassium ion import (GO:0010107)	2.54815075
69	parturition (GO:0007567)	2.54706987
70	L-phenylalanine metabolic process (GO:0006558)	2.52889507
71	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.52889507
72	indolalkylamine metabolic process (GO:0006586)	2.52858310
73	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.51605798
74	glutamate secretion (GO:0014047)	2.51069259
75	reflex (GO:0060004)	2.51068542
76	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.50026943
77	regulation of neurotransmitter uptake (GO:0051580)	2.49922728
78	L-amino acid import (GO:0043092)	2.48132317
79	reverse cholesterol transport (GO:0043691)	2.47473226
80	amine catabolic process (GO:0009310)	2.47446878
81	cellular biogenic amine catabolic process (GO:0042402)	2.47446878
82	neuron-neuron synaptic transmission (GO:0007270)	2.46622074
83	exploration behavior (GO:0035640)	2.46022138
84	steroid catabolic process (GO:0006706)	2.45756670
85	ethanol oxidation (GO:0006069)	2.45161263
86	vocalization behavior (GO:0071625)	2.45144970
87	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.43476700
88	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.43476700
89	amino acid salvage (GO:0043102)	2.43390076
90	L-methionine salvage (GO:0071267)	2.43390076
91	L-methionine biosynthetic process (GO:0071265)	2.43390076
92	aromatic amino acid family metabolic process (GO:0009072)	2.43198324
93	bile acid metabolic process (GO:0008206)	2.42882546
94	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.42123544
95	cilium or flagellum-dependent cell motility (GO:0001539)	2.41781372
96	glyoxylate metabolic process (GO:0046487)	2.41734706
97	ADP metabolic process (GO:0046031)	2.41288417
98	indole-containing compound metabolic process (GO:0042430)	2.41057983
99	chondroitin sulfate catabolic process (GO:0030207)	2.39711088
100	seminiferous tubule development (GO:0072520)	2.39600622

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.98617340
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.90123964
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.34806086
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.25886970
5	VDR_22108803_ChIP-Seq_LS180_Human	2.23363467
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.14499718
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.13782095
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.02565131
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.99523821
10	DROSHA_22980978_ChIP-Seq_HELA_Human	1.95579327
11	TAF15_26573619_Chip-Seq_HEK293_Human	1.95441109
12	REST_21632747_ChIP-Seq_MESCs_Mouse	1.91368712
13	AR_21572438_ChIP-Seq_LNCaP_Human	1.87067796
14	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.83119216
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.77960507
16	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.77451461
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.74216550
18	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.72640001
19	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.72165793
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.68868378
21	ZNF274_21170338_ChIP-Seq_K562_Hela	1.67378394
22	SMAD4_21799915_ChIP-Seq_A2780_Human	1.66684952
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.65496603
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.63378020
25	P300_19829295_ChIP-Seq_ESCs_Human	1.62838140
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.58039670
27	STAT3_23295773_ChIP-Seq_U87_Human	1.56881390
28	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.55772137
29	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.53852514
30	AR_25329375_ChIP-Seq_VCAP_Human	1.51158810
31	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.49538435
32	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.49104281
33	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.47141697
34	TCF4_23295773_ChIP-Seq_U87_Human	1.45405846
35	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.44641302
36	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.44134972
37	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.43840084
38	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.43377823
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41919500
40	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.39617966
41	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.36722211
42	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.34598494
43	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.34348739
44	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.33462129
45	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.33394837
46	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.33322200
47	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.32157750
48	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30638567
49	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.28653741
50	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.28604104
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27662682
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.27662682
53	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.27189259
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.27042721
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26240156
56	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.25331609
57	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.21362296
58	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.20605037
59	FUS_26573619_Chip-Seq_HEK293_Human	1.19092895
60	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.18895169
61	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.18471154
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18453071
63	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.18315354
64	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.18279862
65	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.14888783
66	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.14863265
67	TP53_18474530_ChIP-ChIP_U2OS_Human	1.13563231
68	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.13462857
69	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13113667
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.13047164
71	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.13036176
72	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.13036176
73	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11477085
74	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.10417119
75	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.10205642
76	CDX2_22108803_ChIP-Seq_LS180_Human	1.09636903
77	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.08958402
78	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.08290537
79	TP53_16413492_ChIP-PET_HCT116_Human	1.08181307
80	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.07607253
81	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.07425047
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06692317
83	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.04880312
84	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.04787007
85	KDM2B_26808549_Chip-Seq_REH_Human	1.04572204
86	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04485759
87	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.04053927
88	AR_19668381_ChIP-Seq_PC3_Human	1.03778856
89	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.02209851
90	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.00872851
91	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98383569
92	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.98082587
93	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98082587
94	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97983462
95	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.97619382
96	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.97334708
97	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.96824001
98	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.95531700
99	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.94352710
100	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.93823446

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005646_abnormal_pituitary_gland	3.28143921
2	MP0002139_abnormal_hepatobiliary_system	3.13021156
3	MP0001501_abnormal_sleep_pattern	2.83087589
4	MP0009745_abnormal_behavioral_response	2.73998797
5	MP0003136_yellow_coat_color	2.69927447
6	MP0001968_abnormal_touch/_nociception	2.67434513
7	MP0001486_abnormal_startle_reflex	2.62517679
8	MP0008875_abnormal_xenobiotic_pharmacok	2.59170593
9	MP0003195_calcinosis	2.58224838
10	MP0002064_seizures	2.51820332
11	MP0002736_abnormal_nociception_after	2.49807050
12	MP0009046_muscle_twitch	2.47691976
13	MP0003880_abnormal_central_pattern	2.40054760
14	MP0004859_abnormal_synaptic_plasticity	2.34880974
15	MP0002272_abnormal_nervous_system	2.27313484
16	MP0000569_abnormal_digit_pigmentation	2.25294980
17	MP0005085_abnormal_gallbladder_physiolo	2.18252194
18	MP0003252_abnormal_bile_duct	2.14863451
19	MP0002822_catalepsy	2.14375497
20	MP0003635_abnormal_synaptic_transmissio	2.12223435
21	MP0001984_abnormal_olfaction	2.08411243
22	MP0004885_abnormal_endolymph	2.06054519
23	MP0001986_abnormal_taste_sensitivity	2.00975485
24	MP0005171_absent_coat_pigmentation	2.00451824
25	MP0005551_abnormal_eye_electrophysiolog	1.96029207
26	MP0002138_abnormal_hepatobiliary_system	1.93092480
27	MP0004043_abnormal_pH_regulation	1.89294989
28	MP0002735_abnormal_chemical_nociception	1.88013904
29	MP0002572_abnormal_emotion/affect_behav	1.79953891
30	MP0002063_abnormal_learning/memory/cond	1.76882161
31	MP0001905_abnormal_dopamine_level	1.75026303
32	MP0001970_abnormal_pain_threshold	1.70110233
33	MP0003183_abnormal_peptide_metabolism	1.66783277
34	MP0005365_abnormal_bile_salt	1.66479122
35	MP0002733_abnormal_thermal_nociception	1.61847781
36	MP0002734_abnormal_mechanical_nocicepti	1.60344762
37	MP0004270_analgesia	1.60174497
38	MP0005670_abnormal_white_adipose	1.56500301
39	MP0005167_abnormal_blood-brain_barrier	1.56182762
40	MP0002876_abnormal_thyroid_physiology	1.55910432
41	MP0005174_abnormal_tail_pigmentation	1.50440095
42	MP0003633_abnormal_nervous_system	1.43469879
43	MP0002837_dystrophic_cardiac_calcinosis	1.41482290
44	MP0010329_abnormal_lipoprotein_level	1.38270345
45	MP0005423_abnormal_somatic_nervous	1.35180975
46	MP0004924_abnormal_behavior	1.33192980
47	MP0005386_behavior/neurological_phenoty	1.33192980
48	MP0006276_abnormal_autonomic_nervous	1.30495258
49	MP0002067_abnormal_sensory_capabilities	1.30124845
50	MP0003646_muscle_fatigue	1.25507212
51	MP0003011_delayed_dark_adaptation	1.22551956
52	MP0002909_abnormal_adrenal_gland	1.21729756
53	MP0005253_abnormal_eye_physiology	1.21260649
54	MP0002254_reproductive_system_inflammat	1.20226670
55	MP0005360_urolithiasis	1.18346841
56	MP0002557_abnormal_social/conspecific_i	1.17581793
57	MP0005187_abnormal_penis_morphology	1.15855219
58	MP0003631_nervous_system_phenotype	1.13528415
59	MP0010386_abnormal_urinary_bladder	1.12725498
60	MP0008569_lethality_at_weaning	1.12156093
61	MP0005332_abnormal_amino_acid	1.10421166
62	MP0003806_abnormal_nucleotide_metabolis	1.08486135
63	MP0009780_abnormal_chondrocyte_physiolo	1.05949505
64	MP0000920_abnormal_myelination	1.04850571
65	MP0001502_abnormal_circadian_rhythm	1.04733159
66	MP0004142_abnormal_muscle_tone	1.04691640
67	MP0005379_endocrine/exocrine_gland_phen	1.03651438
68	MP0002229_neurodegeneration	1.03461189
69	MP0003879_abnormal_hair_cell	0.99281184
70	MP0005408_hypopigmentation	0.98515607
71	MP0001485_abnormal_pinna_reflex	0.98064255
72	MP0003632_abnormal_nervous_system	0.97405024
73	MP0003329_amyloid_beta_deposits	0.97055978
74	MP0000639_abnormal_adrenal_gland	0.94321743
75	MP0001963_abnormal_hearing_physiology	0.94228545
76	MP0008872_abnormal_physiological_respon	0.93129282
77	MP0002638_abnormal_pupillary_reflex	0.92073045
78	MP0002118_abnormal_lipid_homeostasis	0.90226286
79	MP0005647_abnormal_sex_gland	0.87820673
80	MP0002653_abnormal_ependyma_morphology	0.87031822
81	MP0002938_white_spotting	0.86860452
82	MP0005075_abnormal_melanosome_morpholog	0.85834023
83	MP0000015_abnormal_ear_pigmentation	0.85750121
84	MP0004019_abnormal_vitamin_homeostasis	0.85323936
85	MP0005310_abnormal_salivary_gland	0.85018246
86	MP0000371_diluted_coat_color	0.84674159
87	MP0004130_abnormal_muscle_cell	0.84213535
88	MP0001756_abnormal_urination	0.82353807
89	MP0002066_abnormal_motor_capabilities/c	0.79089794
90	MP0001440_abnormal_grooming_behavior	0.77995613
91	MP0003045_fibrosis	0.76978044
92	MP0003690_abnormal_glial_cell	0.75686681
93	MP0000026_abnormal_inner_ear	0.75345239
94	MP0005645_abnormal_hypothalamus_physiol	0.74473636
95	MP0002882_abnormal_neuron_morphology	0.73317916
96	MP0005410_abnormal_fertilization	0.73103780
97	MP0000631_abnormal_neuroendocrine_gland	0.73006261
98	MP0000230_abnormal_systemic_arterial	0.72142845
99	MP0004147_increased_porphyrin_level	0.69242395
100	MP0006072_abnormal_retinal_apoptosis	0.67485008

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Action tremor (HP:0002345)	6.04546056
2	Progressive cerebellar ataxia (HP:0002073)	4.52809088
3	Focal motor seizures (HP:0011153)	4.23207422
4	Focal seizures (HP:0007359)	4.06457211
5	Congenital sensorineural hearing impairment (HP:0008527)	4.01872765
6	Genetic anticipation (HP:0003743)	4.01338270
7	Hemiparesis (HP:0001269)	3.74478376
8	Febrile seizures (HP:0002373)	3.65058863
9	Absence seizures (HP:0002121)	3.64331211
10	Hyperventilation (HP:0002883)	3.47342400
11	Gaze-evoked nystagmus (HP:0000640)	3.41760752
12	Dialeptic seizures (HP:0011146)	3.40346859
13	Absent speech (HP:0001344)	3.14501399
14	Atonic seizures (HP:0010819)	3.14245820
15	Hyperglycinuria (HP:0003108)	3.14241660
16	Postural instability (HP:0002172)	3.07773827
17	Blue irides (HP:0000635)	2.90351422
18	True hermaphroditism (HP:0010459)	2.90285611
19	Large for gestational age (HP:0001520)	2.84764943
20	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.83160743
21	Abnormality of glycine metabolism (HP:0010895)	2.68765828
22	Abnormality of serine family amino acid metabolism (HP:0010894)	2.68765828
23	Attenuation of retinal blood vessels (HP:0007843)	2.63596940
24	Hyperglycinemia (HP:0002154)	2.61861426
25	Dysdiadochokinesis (HP:0002075)	2.57543996
26	Congenital stationary night blindness (HP:0007642)	2.56137958
27	Clumsiness (HP:0002312)	2.55817040
28	Pancreatic cysts (HP:0001737)	2.52379319
29	Abolished electroretinogram (ERG) (HP:0000550)	2.51766722
30	Hemiplegia (HP:0002301)	2.50541289
31	Polydipsia (HP:0001959)	2.47320172
32	Abnormal drinking behavior (HP:0030082)	2.47320172
33	Generalized hypopigmentation of hair (HP:0011358)	2.46936580
34	Dysmetric saccades (HP:0000641)	2.42907684
35	Retinal atrophy (HP:0001105)	2.38810357
36	Epileptic encephalopathy (HP:0200134)	2.38472629
37	Postural tremor (HP:0002174)	2.38222021
38	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.35938736
39	Enlarged penis (HP:0000040)	2.34427275
40	Urinary bladder sphincter dysfunction (HP:0002839)	2.32011025
41	Decreased central vision (HP:0007663)	2.31338972
42	Prolonged partial thromboplastin time (HP:0003645)	2.30410432
43	Diplopia (HP:0000651)	2.30376242
44	Abnormality of binocular vision (HP:0011514)	2.30376242
45	Inability to walk (HP:0002540)	2.29342440
46	Fair hair (HP:0002286)	2.29035621
47	Pancreatic fibrosis (HP:0100732)	2.22973306
48	Hyperlipoproteinemia (HP:0010980)	2.21079720
49	Myokymia (HP:0002411)	2.19070788
50	Ketoacidosis (HP:0001993)	2.17296912
51	Xanthomatosis (HP:0000991)	2.14686873
52	Generalized tonic-clonic seizures (HP:0002069)	2.08162084
53	Pendular nystagmus (HP:0012043)	2.07203647
54	Male pseudohermaphroditism (HP:0000037)	2.07076397
55	Arthropathy (HP:0003040)	2.06125717
56	Hypoplasia of the fovea (HP:0007750)	2.04471655
57	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.04471655
58	Abnormality of the hepatic vasculature (HP:0006707)	2.03661443
59	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.98292386
60	Absent/shortened dynein arms (HP:0200106)	1.98292386
61	Ketosis (HP:0001946)	1.97210511
62	Hypokalemic alkalosis (HP:0001949)	1.96325286
63	Impaired vibratory sensation (HP:0002495)	1.95246213
64	Abnormality of midbrain morphology (HP:0002418)	1.93386640
65	Molar tooth sign on MRI (HP:0002419)	1.93386640
66	Complement deficiency (HP:0004431)	1.93069896
67	Bundle branch block (HP:0011710)	1.90332167
68	White forelock (HP:0002211)	1.90023420
69	Progressive inability to walk (HP:0002505)	1.88165297
70	Chronic hepatic failure (HP:0100626)	1.87611844
71	Atrioventricular block (HP:0001678)	1.86868968
72	Epidermoid cyst (HP:0200040)	1.85925556
73	Fetal akinesia sequence (HP:0001989)	1.85362975
74	Increased corneal curvature (HP:0100692)	1.85065853
75	Keratoconus (HP:0000563)	1.85065853
76	Hypobetalipoproteinemia (HP:0003563)	1.83910018
77	Patchy hypopigmentation of hair (HP:0011365)	1.83247862
78	Mesangial abnormality (HP:0001966)	1.83153378
79	Bilateral microphthalmos (HP:0007633)	1.82839288
80	Status epilepticus (HP:0002133)	1.81323346
81	Intellectual disability, progressive (HP:0006887)	1.77112492
82	Impaired smooth pursuit (HP:0007772)	1.75585159
83	Polyuria (HP:0000103)	1.72486695
84	Confusion (HP:0001289)	1.71374889
85	Broad-based gait (HP:0002136)	1.70384439
86	Heart block (HP:0012722)	1.70241920
87	Protruding tongue (HP:0010808)	1.70075265
88	Neurofibrillary tangles (HP:0002185)	1.69804566
89	Abnormality of the renal cortex (HP:0011035)	1.69609719
90	Decreased circulating renin level (HP:0003351)	1.68702171
91	Abnormal biliary tract physiology (HP:0012439)	1.68504710
92	Bile duct proliferation (HP:0001408)	1.68504710
93	Cystic liver disease (HP:0006706)	1.67712880
94	Global brain atrophy (HP:0002283)	1.67435767
95	Abnormal eating behavior (HP:0100738)	1.66519431
96	Anxiety (HP:0000739)	1.66338249
97	Facial diplegia (HP:0001349)	1.64398350
98	Abnormality of macular pigmentation (HP:0008002)	1.63569931
99	Lower limb hyperreflexia (HP:0002395)	1.62406880
100	Medial flaring of the eyebrow (HP:0010747)	1.62365774

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.10577033
2	PINK1	4.28992275
3	EPHA4	3.70513195
4	NTRK3	2.68931674
5	DAPK2	2.65039487
6	OXSR1	2.60290366
7	STK38L	2.56320537
8	WNK3	2.09995565
9	CDK19	2.05319058
10	BMPR1B	2.03612486
11	GRK1	2.00986584
12	CASK	1.98375236
13	TXK	1.91297324
14	PHKG2	1.73563341
15	PHKG1	1.73563341
16	ADRBK2	1.71066876
17	MAPK13	1.66028813
18	FGFR2	1.60191878
19	MARK1	1.59702146
20	LMTK2	1.54767770
21	NTRK2	1.53124162
22	PAK6	1.49598664
23	CAMKK2	1.44744362
24	PRKD3	1.41170309
25	LATS1	1.39120802
26	PRKCG	1.28340780
27	MAPKAPK5	1.22973955
28	TNK2	1.13107793
29	STK38	1.09463616
30	WNK4	1.07275974
31	MAP3K9	1.03221188
32	MAP3K7	1.00640207
33	MAPKAPK3	0.99634463
34	CSNK1G2	0.98421801
35	MUSK	0.98404211
36	CCNB1	0.97349131
37	FER	0.96791862
38	PLK2	0.95915828
39	STK39	0.89206545
40	MAP3K4	0.87702222
41	ZAK	0.84715007
42	CAMK1	0.84525166
43	CDK5	0.80778792
44	CAMK2A	0.80574131
45	CSNK1A1L	0.79578950
46	CSNK1G1	0.78689865
47	PRKAA2	0.78412740
48	PRKCE	0.77307560
49	TIE1	0.76827852
50	CSNK1G3	0.76319349
51	TRPM7	0.75985531
52	CAMKK1	0.74283238
53	PAK3	0.73950041
54	TAOK3	0.71692005
55	SGK223	0.69436547
56	SGK494	0.69436547
57	PTK2B	0.66216985
58	GRK5	0.66165812
59	EEF2K	0.65640397
60	SGK2	0.64309250
61	STK11	0.61662877
62	PRKCZ	0.60655940
63	PNCK	0.56062060
64	DAPK1	0.55691888
65	PIK3CA	0.54855145
66	MAP2K7	0.53130906
67	PRKG1	0.52815161
68	SGK1	0.51651799
69	PKN1	0.50317966
70	CAMK2D	0.49327591
71	PRKACA	0.48414268
72	CSNK1A1	0.47975775
73	ADRBK1	0.47060592
74	ACVR1B	0.45963455
75	PRKCA	0.45704127
76	MAPK12	0.45664888
77	MKNK2	0.44068794
78	OBSCN	0.42662349
79	MINK1	0.41885974
80	NTRK1	0.41455597
81	PDK1	0.41332815
82	PRKCQ	0.40280147
83	TLK1	0.39621453
84	NEK6	0.39408439
85	CSNK1D	0.38631178
86	PRKCH	0.37890931
87	RPS6KB1	0.37764495
88	IGF1R	0.37606017
89	MAPK15	0.37574544
90	PDPK1	0.36570231
91	PDK2	0.36463470
92	TYRO3	0.35770377
93	RPS6KA3	0.35716373
94	CAMK2B	0.35689090
95	DYRK1A	0.35554392
96	MAPK11	0.35439564
97	SIK2	0.35247766
98	PRKAA1	0.34304982
99	GSK3A	0.32140273
100	ERBB2	0.32048428

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.64304684
2	Butanoate metabolism_Homo sapiens_hsa00650	2.65576855
3	Nicotine addiction_Homo sapiens_hsa05033	2.32391477
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.10128910
5	Caffeine metabolism_Homo sapiens_hsa00232	2.09944436
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.00996482
7	Histidine metabolism_Homo sapiens_hsa00340	2.00534003
8	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.96801779
9	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.90186012
10	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.89000856
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.87749396
12	Propanoate metabolism_Homo sapiens_hsa00640	1.84542156
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.81756881
14	Retinol metabolism_Homo sapiens_hsa00830	1.77405696
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.72459339
16	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.72133884
17	GABAergic synapse_Homo sapiens_hsa04727	1.67893632
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.57808578
19	Arginine biosynthesis_Homo sapiens_hsa00220	1.55406225
20	Fatty acid degradation_Homo sapiens_hsa00071	1.52029485
21	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.51842198
22	Morphine addiction_Homo sapiens_hsa05032	1.51671639
23	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.49874250
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.47305939
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.46792197
26	Chemical carcinogenesis_Homo sapiens_hsa05204	1.46456153
27	Olfactory transduction_Homo sapiens_hsa04740	1.46043220
28	Complement and coagulation cascades_Homo sapiens_hsa04610	1.44211186
29	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.43217599
30	Insulin secretion_Homo sapiens_hsa04911	1.42258628
31	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.41600726
32	Glutamatergic synapse_Homo sapiens_hsa04724	1.41027340
33	ABC transporters_Homo sapiens_hsa02010	1.39158836
34	Salivary secretion_Homo sapiens_hsa04970	1.38818815
35	Circadian entrainment_Homo sapiens_hsa04713	1.37503106
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.37124476
37	Ether lipid metabolism_Homo sapiens_hsa00565	1.34839487
38	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.33510491
39	Phototransduction_Homo sapiens_hsa04744	1.26987356
40	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.26670890
41	Bile secretion_Homo sapiens_hsa04976	1.24723516
42	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.23153780
43	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.22858250
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.20062520
45	PPAR signaling pathway_Homo sapiens_hsa03320	1.17409333
46	Peroxisome_Homo sapiens_hsa04146	1.14864312
47	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.13095526
48	Circadian rhythm_Homo sapiens_hsa04710	1.12856120
49	beta-Alanine metabolism_Homo sapiens_hsa00410	1.11015646
50	Calcium signaling pathway_Homo sapiens_hsa04020	1.08797230
51	Gastric acid secretion_Homo sapiens_hsa04971	1.07214989
52	Amphetamine addiction_Homo sapiens_hsa05031	1.01512108
53	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.98152831
54	Taste transduction_Homo sapiens_hsa04742	0.97941321
55	Serotonergic synapse_Homo sapiens_hsa04726	0.97578341
56	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.97307375
57	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.94544935
58	Arginine and proline metabolism_Homo sapiens_hsa00330	0.94249688
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.91527546
60	Tyrosine metabolism_Homo sapiens_hsa00350	0.90975806
61	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.90826343
62	Selenocompound metabolism_Homo sapiens_hsa00450	0.86803047
63	cAMP signaling pathway_Homo sapiens_hsa04024	0.86511322
64	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.85892721
65	Fatty acid metabolism_Homo sapiens_hsa01212	0.80551756
66	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.79579584
67	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.78918357
68	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.77489108
69	Dopaminergic synapse_Homo sapiens_hsa04728	0.75301471
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.74944525
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.74693625
72	Cholinergic synapse_Homo sapiens_hsa04725	0.74662914
73	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.71203292
74	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.70814489
75	Renin secretion_Homo sapiens_hsa04924	0.70566849
76	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.69601313
77	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.69522546
78	Phenylalanine metabolism_Homo sapiens_hsa00360	0.67277333
79	Cocaine addiction_Homo sapiens_hsa05030	0.64995392
80	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.64852563
81	Long-term depression_Homo sapiens_hsa04730	0.64755043
82	Collecting duct acid secretion_Homo sapiens_hsa04966	0.60608749
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.60487213
84	Pyruvate metabolism_Homo sapiens_hsa00620	0.59697512
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57760180
86	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.54337487
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.53110308
88	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.53071546
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.52933687
90	Sphingolipid metabolism_Homo sapiens_hsa00600	0.52607113
91	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.48311501
92	Pancreatic secretion_Homo sapiens_hsa04972	0.48181852
93	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.42594214
94	Metabolic pathways_Homo sapiens_hsa01100	0.42348789
95	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.42154543
96	Glucagon signaling pathway_Homo sapiens_hsa04922	0.41486291
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.40846072
98	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.38995143
99	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.38952247
100	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.38941318

LINC01314

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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