ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	6.68303194
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	6.12357307
3	midbrain development (GO:0030901)	5.68643956
4	dopaminergic neuron differentiation (GO:0071542)	5.02360227
5	epithelial cilium movement (GO:0003351)	4.91683551
6	sequestering of actin monomers (GO:0042989)	4.91163256
7	cilium movement (GO:0003341)	4.42564815
8	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.42344812
9	microtubule depolymerization (GO:0007019)	4.38290835
10	behavioral response to nicotine (GO:0035095)	4.27626149
11	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.24170276
12	spermatid nucleus differentiation (GO:0007289)	4.15146467
13	limb bud formation (GO:0060174)	4.05500546
14	somite development (GO:0061053)	3.95513444
15	centriole replication (GO:0007099)	3.93320433
16	positive regulation of gastrulation (GO:2000543)	3.79634937
17	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.67133371
18	ATP synthesis coupled proton transport (GO:0015986)	3.67133371
19	viral transcription (GO:0019083)	3.56657467
20	tachykinin receptor signaling pathway (GO:0007217)	3.51673450
21	ventricular system development (GO:0021591)	3.50448508
22	retinal ganglion cell axon guidance (GO:0031290)	3.44700278
23	translational termination (GO:0006415)	3.41323492
24	pyrimidine nucleobase catabolic process (GO:0006208)	3.41209208
25	thalamus development (GO:0021794)	3.35266862
26	neuron fate determination (GO:0048664)	3.34018762
27	positive regulation of embryonic development (GO:0040019)	3.29908949
28	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.29091559
29	GTP biosynthetic process (GO:0006183)	3.25558613
30	negative regulation of axon guidance (GO:1902668)	3.23064251
31	cochlea development (GO:0090102)	3.22123290
32	intraciliary transport (GO:0042073)	3.20771728
33	hindbrain development (GO:0030902)	3.20648995
34	DNA damage response, detection of DNA damage (GO:0042769)	3.17798603
35	motile cilium assembly (GO:0044458)	3.14987653
36	respiratory electron transport chain (GO:0022904)	3.12770203
37	electron transport chain (GO:0022900)	3.12167901
38	centriole assembly (GO:0098534)	3.03206114
39	positive regulation of digestive system process (GO:0060456)	3.01107283
40	relaxation of smooth muscle (GO:0044557)	2.98484726
41	regulation of timing of cell differentiation (GO:0048505)	2.97991043
42	otic vesicle formation (GO:0030916)	2.97695408
43	gamma-aminobutyric acid transport (GO:0015812)	2.97231537
44	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.96049424
45	NADH dehydrogenase complex assembly (GO:0010257)	2.96049424
46	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.96049424
47	protein polyglutamylation (GO:0018095)	2.91723030
48	inner mitochondrial membrane organization (GO:0007007)	2.89218693
49	microtubule polymerization or depolymerization (GO:0031109)	2.88710366
50	proteasome assembly (GO:0043248)	2.87153919
51	protein complex biogenesis (GO:0070271)	2.86127068
52	cotranslational protein targeting to membrane (GO:0006613)	2.83383825
53	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.77406218
54	substrate-independent telencephalic tangential migration (GO:0021826)	2.77406218
55	regulation of development, heterochronic (GO:0040034)	2.76391416
56	cell proliferation in forebrain (GO:0021846)	2.75442062
57	cellular protein complex disassembly (GO:0043624)	2.73390431
58	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.71788517
59	protein targeting to ER (GO:0045047)	2.71187068
60	protein neddylation (GO:0045116)	2.71040201
61	DNA double-strand break processing (GO:0000729)	2.70893676
62	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.70033700
63	sperm motility (GO:0030317)	2.68667297
64	adaptation of signaling pathway (GO:0023058)	2.67360125
65	dentate gyrus development (GO:0021542)	2.65849110
66	sulfation (GO:0051923)	2.65419247
67	nucleobase catabolic process (GO:0046113)	2.63421829
68	translational elongation (GO:0006414)	2.62992920
69	positive regulation of meiosis (GO:0045836)	2.61070693
70	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.59782582
71	smoothened signaling pathway (GO:0007224)	2.59680517
72	dorsal/ventral neural tube patterning (GO:0021904)	2.59098556
73	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.58650616
74	left/right pattern formation (GO:0060972)	2.58176916
75	cilium organization (GO:0044782)	2.57590879
76	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.57508107
77	axon extension involved in axon guidance (GO:0048846)	2.57508107
78	mitochondrial respiratory chain complex assembly (GO:0033108)	2.56084480
79	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.55355188
80	positive regulation of meiotic cell cycle (GO:0051446)	2.55240512
81	cilium assembly (GO:0042384)	2.54942124
82	cartilage morphogenesis (GO:0060536)	2.54499069
83	UTP metabolic process (GO:0046051)	2.54498172
84	positive regulation of catecholamine secretion (GO:0033605)	2.54267481
85	acrosome reaction (GO:0007340)	2.53601549
86	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.53575207
87	regulation of male gonad development (GO:2000018)	2.53417218
88	negative regulation of telomere maintenance (GO:0032205)	2.53142541
89	postsynaptic membrane organization (GO:0001941)	2.52945184
90	UTP biosynthetic process (GO:0006228)	2.52900540
91	ganglion development (GO:0061548)	2.52601504
92	regulation of telomere maintenance (GO:0032204)	2.51798779
93	determination of left/right symmetry (GO:0007368)	2.51444225
94	transmission of nerve impulse (GO:0019226)	2.49334536
95	protein localization to endoplasmic reticulum (GO:0070972)	2.49242307
96	indolalkylamine metabolic process (GO:0006586)	2.46737866
97	viral life cycle (GO:0019058)	2.44988618
98	hematopoietic stem cell proliferation (GO:0071425)	2.43419060
99	telencephalon development (GO:0021537)	2.43150209
100	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.41971848

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.74443318
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.59851089
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.46651970
4	VDR_22108803_ChIP-Seq_LS180_Human	3.22147812
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.07260120
6	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.98689060
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.76914087
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.54480204
9	FUS_26573619_Chip-Seq_HEK293_Human	2.51286787
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.40136164
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.20373486
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20122425
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.19906591
14	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.18069141
15	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.14234935
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.14162476
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.10523217
18	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.06207211
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.99461272
20	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.94434774
21	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.91676248
22	RNF2_27304074_Chip-Seq_NSC_Mouse	1.89166266
23	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.84198498
24	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.82658995
25	P300_19829295_ChIP-Seq_ESCs_Human	1.82152880
26	EWS_26573619_Chip-Seq_HEK293_Human	1.78422541
27	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.72089039
28	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.70087657
29	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.69934250
30	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.67354225
31	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.64997460
32	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.62671150
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.58373941
34	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.58143914
35	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.57130771
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57130771
37	TAF15_26573619_Chip-Seq_HEK293_Human	1.56672903
38	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.55505622
39	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.53827602
40	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.53099865
41	AR_21572438_ChIP-Seq_LNCaP_Human	1.50344207
42	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.49118627
43	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.44299269
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.42537615
45	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.41796009
46	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.41796009
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.40730381
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40730381
49	ER_23166858_ChIP-Seq_MCF-7_Human	1.40472996
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.36211966
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35943383
52	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.35223878
53	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.33092767
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.33067747
55	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.32624924
56	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.32349669
57	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.31840206
58	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30767206
59	SMAD4_21799915_ChIP-Seq_A2780_Human	1.29876691
60	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.29113511
61	IRF1_19129219_ChIP-ChIP_H3396_Human	1.28923077
62	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.26943531
63	AR_25329375_ChIP-Seq_VCAP_Human	1.26776095
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.21442140
65	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.19943996
66	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.19148655
67	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.19008805
68	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18918820
69	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.18374738
70	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.15521152
71	REST_21632747_ChIP-Seq_MESCs_Mouse	1.15178954
72	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.14362535
73	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.14209823
74	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.11602500
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10677293
76	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.09889603
77	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.07866364
78	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.06408528
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03989936
80	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02908432
81	TCF4_22108803_ChIP-Seq_LS180_Human	1.02666831
82	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01370077
83	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.98850705
84	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.97465848
85	MYC_18940864_ChIP-ChIP_HL60_Human	0.95988615
86	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.95540244
87	NANOG_19829295_ChIP-Seq_ESCs_Human	0.95418866
88	SOX2_19829295_ChIP-Seq_ESCs_Human	0.95418866
89	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.95410349
90	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.95057400
91	STAT3_23295773_ChIP-Seq_U87_Human	0.94804205
92	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.93993155
93	TBL1_22424771_ChIP-Seq_293T_Human	0.92681593
94	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.92585545
95	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.91608101
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.91545702
97	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.90098199
98	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.89611680
99	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.88548464
100	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.87574664

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	5.11593508
2	MP0003136_yellow_coat_color	3.20391048
3	MP0010030_abnormal_orbit_morphology	2.67790653
4	MP0002938_white_spotting	2.62176345
5	MP0009379_abnormal_foot_pigmentation	2.44502632
6	MP0001529_abnormal_vocalization	2.43113612
7	MP0005171_absent_coat_pigmentation	2.11344632
8	MP0002736_abnormal_nociception_after	2.09870572
9	MP0002638_abnormal_pupillary_reflex	2.04009902
10	MP0003315_abnormal_perineum_morphology	2.02054526
11	MP0005646_abnormal_pituitary_gland	1.98338380
12	MP0003880_abnormal_central_pattern	1.94485700
13	MP0002837_dystrophic_cardiac_calcinosis	1.92017327
14	MP0006276_abnormal_autonomic_nervous	1.90733877
15	MP0005248_abnormal_Harderian_gland	1.86059556
16	MP0000778_abnormal_nervous_system	1.83778234
17	MP0001346_abnormal_lacrimal_gland	1.79499381
18	MP0000631_abnormal_neuroendocrine_gland	1.79458402
19	MP0000569_abnormal_digit_pigmentation	1.78420553
20	MP0004133_heterotaxia	1.77455581
21	MP0003283_abnormal_digestive_organ	1.72945160
22	MP0004145_abnormal_muscle_electrophysio	1.65870011
23	MP0001968_abnormal_touch/_nociception	1.62841555
24	MP0002234_abnormal_pharynx_morphology	1.59644087
25	MP0001905_abnormal_dopamine_level	1.54541889
26	MP0000026_abnormal_inner_ear	1.54177820
27	MP0002102_abnormal_ear_morphology	1.53190500
28	MP0003011_delayed_dark_adaptation	1.50979426
29	MP0003937_abnormal_limbs/digits/tail_de	1.49970803
30	MP0003938_abnormal_ear_development	1.43539233
31	MP0005410_abnormal_fertilization	1.42235169
32	MP0002751_abnormal_autonomic_nervous	1.40822308
33	MP0005253_abnormal_eye_physiology	1.39782341
34	MP0002282_abnormal_trachea_morphology	1.36589370
35	MP0009745_abnormal_behavioral_response	1.35199934
36	MP0005423_abnormal_somatic_nervous	1.35074591
37	MP0004142_abnormal_muscle_tone	1.32460568
38	MP0003119_abnormal_digestive_system	1.31841799
39	MP0002653_abnormal_ependyma_morphology	1.31448686
40	MP0005551_abnormal_eye_electrophysiolog	1.27631300
41	MP0002735_abnormal_chemical_nociception	1.25660783
42	MP0002249_abnormal_larynx_morphology	1.25450277
43	MP0000537_abnormal_urethra_morphology	1.23523327
44	MP0005394_taste/olfaction_phenotype	1.23416474
45	MP0005499_abnormal_olfactory_system	1.23416474
46	MP0010386_abnormal_urinary_bladder	1.21510446
47	MP0000049_abnormal_middle_ear	1.21499349
48	MP0006292_abnormal_olfactory_placode	1.19810802
49	MP0003698_abnormal_male_reproductive	1.19803474
50	MP0001293_anophthalmia	1.18591666
51	MP0009697_abnormal_copulation	1.15973221
52	MP0003890_abnormal_embryonic-extraembry	1.15206591
53	MP0008789_abnormal_olfactory_epithelium	1.15058911
54	MP0001501_abnormal_sleep_pattern	1.14747096
55	MP0002277_abnormal_respiratory_mucosa	1.14132079
56	MP0002928_abnormal_bile_duct	1.13974495
57	MP0009250_abnormal_appendicular_skeleto	1.13474000
58	MP0002127_abnormal_cardiovascular_syste	1.10633544
59	MP0005377_hearing/vestibular/ear_phenot	1.09873004
60	MP0003878_abnormal_ear_physiology	1.09873004
61	MP0001486_abnormal_startle_reflex	1.09360484
62	MP0008995_early_reproductive_senescence	1.08879579
63	MP0002064_seizures	1.08865584
64	MP0002572_abnormal_emotion/affect_behav	1.08398471
65	MP0005084_abnormal_gallbladder_morpholo	1.07828008
66	MP0002272_abnormal_nervous_system	1.07807407
67	MP0000955_abnormal_spinal_cord	1.07520194
68	MP0000749_muscle_degeneration	1.06895382
69	MP0002734_abnormal_mechanical_nocicepti	1.06127296
70	MP0001984_abnormal_olfaction	1.03563524
71	MP0004147_increased_porphyrin_level	1.01932655
72	MP0001485_abnormal_pinna_reflex	1.01290059
73	MP0001963_abnormal_hearing_physiology	1.01144185
74	MP0002067_abnormal_sensory_capabilities	1.00711649
75	MP0002752_abnormal_somatic_nervous	0.99594437
76	MP0006072_abnormal_retinal_apoptosis	0.98133277
77	MP0005670_abnormal_white_adipose	0.97611282
78	MP0003195_calcinosis	0.95702415
79	MP0000579_abnormal_nail_morphology	0.95685860
80	MP0004215_abnormal_myocardial_fiber	0.94920453
81	MP0009046_muscle_twitch	0.93642969
82	MP0005391_vision/eye_phenotype	0.93448024
83	MP0003635_abnormal_synaptic_transmissio	0.93337964
84	MP0005503_abnormal_tendon_morphology	0.93311081
85	MP0008961_abnormal_basal_metabolism	0.93007555
86	MP0005187_abnormal_penis_morphology	0.90789590
87	MP0002160_abnormal_reproductive_system	0.89792872
88	MP0002822_catalepsy	0.88259677
89	MP0003942_abnormal_urinary_system	0.86936377
90	MP0001324_abnormal_eye_pigmentation	0.85565860
91	MP0002184_abnormal_innervation	0.84689250
92	MP0001929_abnormal_gametogenesis	0.83725681
93	MP0002063_abnormal_learning/memory/cond	0.83188655
94	MP0003755_abnormal_palate_morphology	0.82624589
95	MP0000538_abnormal_urinary_bladder	0.82115414
96	MP0001286_abnormal_eye_development	0.81918930
97	MP0004885_abnormal_endolymph	0.78999385
98	MP0002210_abnormal_sex_determination	0.78332425
99	MP0003861_abnormal_nervous_system	0.76376694
100	MP0000751_myopathy	0.75964543

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium physiology (HP:0012261)	5.17021858
2	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.02386635
3	Abnormal ciliary motility (HP:0012262)	4.88928496
4	Congenital, generalized hypertrichosis (HP:0004540)	4.77206417
5	Abnormal respiratory epithelium morphology (HP:0012253)	4.75789201
6	Abnormal respiratory motile cilium morphology (HP:0005938)	4.75789201
7	Rhinitis (HP:0012384)	4.12392786
8	Hypothermia (HP:0002045)	3.89926153
9	True hermaphroditism (HP:0010459)	3.80855457
10	Pancreatic cysts (HP:0001737)	3.50964523
11	Pancreatic fibrosis (HP:0100732)	3.39646303
12	Concave nail (HP:0001598)	3.37203217
13	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.13284917
14	Absent/shortened dynein arms (HP:0200106)	3.13284917
15	Limb dystonia (HP:0002451)	3.02587724
16	Acute necrotizing encephalopathy (HP:0006965)	2.93689166
17	Mitochondrial inheritance (HP:0001427)	2.79372682
18	Lipid accumulation in hepatocytes (HP:0006561)	2.74421037
19	Focal motor seizures (HP:0011153)	2.74210104
20	Septo-optic dysplasia (HP:0100842)	2.68556727
21	Chronic bronchitis (HP:0004469)	2.64274006
22	Nephronophthisis (HP:0000090)	2.63791212
23	Increased hepatocellular lipid droplets (HP:0006565)	2.63333484
24	Occipital encephalocele (HP:0002085)	2.62640342
25	Anencephaly (HP:0002323)	2.61656572
26	Prominent supraorbital ridges (HP:0000336)	2.55406241
27	Cystic liver disease (HP:0006706)	2.50196706
28	Male pseudohermaphroditism (HP:0000037)	2.43150375
29	Progressive macrocephaly (HP:0004481)	2.42652523
30	Acute encephalopathy (HP:0006846)	2.42128955
31	Bilateral microphthalmos (HP:0007633)	2.41393942
32	Pendular nystagmus (HP:0012043)	2.41178836
33	Chronic hepatic failure (HP:0100626)	2.40045866
34	Sclerocornea (HP:0000647)	2.33078515
35	Chronic sinusitis (HP:0011109)	2.30348128
36	Maternal diabetes (HP:0009800)	2.29857665
37	Abnormal mitochondria in muscle tissue (HP:0008316)	2.28805537
38	Medial flaring of the eyebrow (HP:0010747)	2.25757834
39	Renal Fanconi syndrome (HP:0001994)	2.24863452
40	Myokymia (HP:0002411)	2.24026025
41	Hepatocellular necrosis (HP:0001404)	2.23754708
42	Birth length less than 3rd percentile (HP:0003561)	2.22050718
43	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.21821690
44	Calf muscle hypertrophy (HP:0008981)	2.20226877
45	Muscle hypertrophy of the lower extremities (HP:0008968)	2.18960697
46	Sex reversal (HP:0012245)	2.18457179
47	Abnormal sex determination (HP:0012244)	2.18457179
48	Abnormality of macular pigmentation (HP:0008002)	2.15321674
49	Tubulointerstitial nephritis (HP:0001970)	2.12713206
50	Type II lissencephaly (HP:0007260)	2.12378946
51	Reticulocytopenia (HP:0001896)	2.12015580
52	Abnormality of the renal medulla (HP:0100957)	2.10162742
53	Esophageal atresia (HP:0002032)	2.09513272
54	Genital tract atresia (HP:0001827)	2.09357027
55	Abnormal number of erythroid precursors (HP:0012131)	2.07812566
56	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.07362506
57	Abnormality of urine glucose concentration (HP:0011016)	2.06813985
58	Glycosuria (HP:0003076)	2.06813985
59	Inability to walk (HP:0002540)	2.04677750
60	Vaginal atresia (HP:0000148)	2.02694738
61	Optic disc pallor (HP:0000543)	2.01492038
62	Anophthalmia (HP:0000528)	1.99394014
63	Optic nerve hypoplasia (HP:0000609)	1.98247826
64	Gait imbalance (HP:0002141)	1.96459139
65	Abnormality of cells of the erythroid lineage (HP:0012130)	1.93708727
66	Increased CSF lactate (HP:0002490)	1.93062132
67	Rimmed vacuoles (HP:0003805)	1.92152381
68	Hepatic necrosis (HP:0002605)	1.90480656
69	Cerebellar dysplasia (HP:0007033)	1.88835286
70	Furrowed tongue (HP:0000221)	1.88056273
71	Woolly hair (HP:0002224)	1.86416520
72	Congenital primary aphakia (HP:0007707)	1.85024915
73	Congenital hepatic fibrosis (HP:0002612)	1.84715599
74	Lissencephaly (HP:0001339)	1.83971742
75	Exertional dyspnea (HP:0002875)	1.82202696
76	Bronchiectasis (HP:0002110)	1.81053022
77	Abnormality of midbrain morphology (HP:0002418)	1.80969220
78	Molar tooth sign on MRI (HP:0002419)	1.80969220
79	Congenital sensorineural hearing impairment (HP:0008527)	1.80074231
80	Gastrointestinal atresia (HP:0002589)	1.78688880
81	Hyperphosphaturia (HP:0003109)	1.75494311
82	Abnormality of the labia minora (HP:0012880)	1.74530224
83	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.72698265
84	Generalized myoclonic seizures (HP:0002123)	1.69564635
85	Postaxial foot polydactyly (HP:0001830)	1.69132735
86	Dialeptic seizures (HP:0011146)	1.68540127
87	Generalized aminoaciduria (HP:0002909)	1.66801153
88	Neonatal respiratory distress (HP:0002643)	1.65879001
89	Retinal dysplasia (HP:0007973)	1.65059589
90	Midline defect of the nose (HP:0004122)	1.64942932
91	Attenuation of retinal blood vessels (HP:0007843)	1.64918111
92	Abnormality of the pubic bones (HP:0003172)	1.64498905
93	Nephrogenic diabetes insipidus (HP:0009806)	1.63552285
94	Oligodactyly (hands) (HP:0001180)	1.63184688
95	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.62026453
96	Short 4th metacarpal (HP:0010044)	1.62026453
97	Constricted visual fields (HP:0001133)	1.61547695
98	Patellar aplasia (HP:0006443)	1.61411562
99	Bony spicule pigmentary retinopathy (HP:0007737)	1.59379196
100	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.56801754

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	5.06255260
2	PNCK	4.01953888
3	CCNB1	3.21327360
4	OBSCN	2.67778708
5	TLK1	2.51188652
6	UHMK1	2.49325320
7	WNK3	2.44065799
8	WEE1	2.41983792
9	EPHB2	2.26853891
10	VRK2	2.24051419
11	DYRK3	2.16512870
12	NEK1	2.08098740
13	MAPK15	2.06998720
14	MARK1	2.01804364
15	MAPK13	1.99886662
16	MAP3K4	1.96820009
17	VRK1	1.91273728
18	MARK3	1.91269158
19	NEK2	1.88138176
20	INSRR	1.84992448
21	FRK	1.84254741
22	BMPR1B	1.63485991
23	CASK	1.50682590
24	DYRK2	1.49387369
25	MAP2K7	1.46334629
26	TNIK	1.45100001
27	TIE1	1.43900457
28	ZAK	1.35160008
29	PASK	1.34338122
30	TGFBR1	1.27353801
31	MINK1	1.20997776
32	STK38L	1.20812603
33	FGFR2	1.19471192
34	SRPK1	1.16053122
35	STK16	1.13640711
36	MKNK1	1.13207227
37	LATS2	1.10437431
38	MAP2K4	1.07284345
39	PRKCG	0.99562607
40	MYLK	0.94637541
41	ADRBK2	0.93701639
42	CDK3	0.91748766
43	NTRK2	0.89949280
44	CDC7	0.86621067
45	BUB1	0.83301844
46	EPHA4	0.81043495
47	CDK8	0.78929722
48	KSR1	0.78788430
49	NME1	0.74959569
50	LATS1	0.74227137
51	SGK223	0.73566040
52	SGK494	0.73566040
53	MKNK2	0.72235837
54	ADRBK1	0.71086388
55	PLK3	0.68883269
56	GRK7	0.68057781
57	STK3	0.64509641
58	SIK1	0.62594032
59	MAP4K2	0.62300506
60	AURKB	0.62125753
61	PRKCE	0.61837967
62	PHKG2	0.59885053
63	PHKG1	0.59885053
64	RPS6KA5	0.59572275
65	SGK2	0.59285348
66	PRKG1	0.58983587
67	DYRK1B	0.58082940
68	BRSK2	0.57287642
69	GRK1	0.56365085
70	NUAK1	0.50503490
71	PRKACB	0.48870465
72	STK11	0.48315038
73	CAMK2B	0.46173777
74	CSNK1A1	0.45792509
75	NTRK3	0.45462949
76	PKN1	0.44452341
77	PRKACA	0.43542401
78	PLK1	0.43205815
79	OXSR1	0.41919022
80	AURKA	0.41782810
81	DYRK1A	0.41693967
82	RPS6KA4	0.38875482
83	BCR	0.37301315
84	PAK3	0.37025347
85	CDK5	0.36700261
86	CAMK2A	0.35200310
87	STK4	0.35024317
88	CAMK1	0.34966684
89	PIK3CA	0.34423986
90	PRKCZ	0.32304232
91	STK39	0.31307085
92	MUSK	0.30452406
93	MAPK4	0.29325932
94	CDK14	0.28683787
95	ROCK1	0.27991334
96	ERBB2	0.27444068
97	ATM	0.26081029
98	PRKCQ	0.25244588
99	CSNK2A1	0.25021704
100	ATR	0.23654853

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.63419669
2	Parkinsons disease_Homo sapiens_hsa05012	3.40896769
3	Ribosome_Homo sapiens_hsa03010	3.37754875
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.71967360
5	Nicotine addiction_Homo sapiens_hsa05033	2.61877449
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.47670982
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.46419765
8	Butanoate metabolism_Homo sapiens_hsa00650	2.43863433
9	Huntingtons disease_Homo sapiens_hsa05016	2.38704957
10	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.28473908
11	Alzheimers disease_Homo sapiens_hsa05010	2.13351523
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.04905663
13	Basal cell carcinoma_Homo sapiens_hsa05217	2.01379116
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.89993182
15	Propanoate metabolism_Homo sapiens_hsa00640	1.85897245
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.75925015
17	RNA polymerase_Homo sapiens_hsa03020	1.72684073
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.72658396
19	GABAergic synapse_Homo sapiens_hsa04727	1.67735423
20	Taste transduction_Homo sapiens_hsa04742	1.65839311
21	Morphine addiction_Homo sapiens_hsa05032	1.57487394
22	Olfactory transduction_Homo sapiens_hsa04740	1.56580093
23	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.46524458
24	Protein export_Homo sapiens_hsa03060	1.42725174
25	Phototransduction_Homo sapiens_hsa04744	1.42719999
26	Proteasome_Homo sapiens_hsa03050	1.42261764
27	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.40164912
28	Gap junction_Homo sapiens_hsa04540	1.39916511
29	Histidine metabolism_Homo sapiens_hsa00340	1.39128333
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.37459441
31	Circadian entrainment_Homo sapiens_hsa04713	1.35405408
32	Cocaine addiction_Homo sapiens_hsa05030	1.28567289
33	beta-Alanine metabolism_Homo sapiens_hsa00410	1.28053932
34	RNA degradation_Homo sapiens_hsa03018	1.21609151
35	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.20701370
36	Alcoholism_Homo sapiens_hsa05034	1.12984418
37	Serotonergic synapse_Homo sapiens_hsa04726	1.11885204
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.04843501
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.02185939
40	Glutamatergic synapse_Homo sapiens_hsa04724	0.99274319
41	Spliceosome_Homo sapiens_hsa03040	0.94874858
42	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.93791785
43	Basal transcription factors_Homo sapiens_hsa03022	0.91569036
44	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.88989692
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.88203885
46	Cholinergic synapse_Homo sapiens_hsa04725	0.83446761
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.81962742
48	Phenylalanine metabolism_Homo sapiens_hsa00360	0.81730913
49	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.81464905
50	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.81107365
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78960767
52	Amphetamine addiction_Homo sapiens_hsa05031	0.78883451
53	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.78140034
54	Purine metabolism_Homo sapiens_hsa00230	0.77669963
55	Dopaminergic synapse_Homo sapiens_hsa04728	0.76901357
56	Homologous recombination_Homo sapiens_hsa03440	0.76872402
57	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.75513346
58	Linoleic acid metabolism_Homo sapiens_hsa00591	0.74155002
59	Circadian rhythm_Homo sapiens_hsa04710	0.72766985
60	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.68983707
61	Melanogenesis_Homo sapiens_hsa04916	0.68299650
62	Calcium signaling pathway_Homo sapiens_hsa04020	0.67489237
63	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.65645851
64	Insulin secretion_Homo sapiens_hsa04911	0.65542741
65	Wnt signaling pathway_Homo sapiens_hsa04310	0.65414449
66	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.63904792
67	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.63809619
68	Peroxisome_Homo sapiens_hsa04146	0.62155480
69	Tyrosine metabolism_Homo sapiens_hsa00350	0.60747481
70	Axon guidance_Homo sapiens_hsa04360	0.60400020
71	Regulation of autophagy_Homo sapiens_hsa04140	0.59494138
72	Pyruvate metabolism_Homo sapiens_hsa00620	0.57605451
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.57117209
74	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.56734050
75	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.56557413
76	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.56464353
77	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.55616005
78	Fatty acid degradation_Homo sapiens_hsa00071	0.55576537
79	Renin secretion_Homo sapiens_hsa04924	0.55568015
80	Glutathione metabolism_Homo sapiens_hsa00480	0.54809510
81	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.54801530
82	Hippo signaling pathway_Homo sapiens_hsa04390	0.51317524
83	Metabolic pathways_Homo sapiens_hsa01100	0.49734842
84	Pyrimidine metabolism_Homo sapiens_hsa00240	0.46684614
85	Caffeine metabolism_Homo sapiens_hsa00232	0.46410164
86	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.45443473
87	Retinol metabolism_Homo sapiens_hsa00830	0.45434981
88	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.45352346
89	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.41717068
90	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.41185628
91	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.41050822
92	Salivary secretion_Homo sapiens_hsa04970	0.38834030
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.38572655
94	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38095286
95	Nucleotide excision repair_Homo sapiens_hsa03420	0.37561513
96	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.36978789
97	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.34864544
98	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.33131637
99	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.33117800
100	Arginine and proline metabolism_Homo sapiens_hsa00330	0.31603879

LINC01330

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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