ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	9.31832695
2	acrosome reaction (GO:0007340)	8.84842240
3	response to pheromone (GO:0019236)	8.42590211
4	fusion of sperm to egg plasma membrane (GO:0007342)	7.53416518
5	single strand break repair (GO:0000012)	7.40114795
6	spermatid development (GO:0007286)	6.55702396
7	microtubule depolymerization (GO:0007019)	6.49799207
8	spermatid nucleus differentiation (GO:0007289)	6.30511670
9	multicellular organism reproduction (GO:0032504)	6.18791624
10	regulation of cilium movement (GO:0003352)	6.06698619
11	establishment of protein localization to Golgi (GO:0072600)	6.02277429
12	protein targeting to Golgi (GO:0000042)	5.92751748
13	axonemal dynein complex assembly (GO:0070286)	5.84843930
14	cilium or flagellum-dependent cell motility (GO:0001539)	5.81753861
15	plasma membrane fusion (GO:0045026)	5.78470126
16	protein polyglutamylation (GO:0018095)	5.73788359
17	sperm-egg recognition (GO:0035036)	5.71135533
18	sperm capacitation (GO:0048240)	5.67809887
19	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.41041284
20	centriole replication (GO:0007099)	5.34106361
21	epithelial cilium movement (GO:0003351)	5.25525749
22	reproduction (GO:0000003)	5.20603998
23	DNA packaging (GO:0006323)	5.18408814
24	microtubule polymerization or depolymerization (GO:0031109)	5.18013050
25	chromosome condensation (GO:0030261)	5.15621047
26	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.12461601
27	cell wall macromolecule catabolic process (GO:0016998)	5.03041233
28	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.94310248
29	cellular ketone body metabolic process (GO:0046950)	4.94118783
30	cell-cell recognition (GO:0009988)	4.82911747
31	phosphatidylethanolamine metabolic process (GO:0046337)	4.78790774
32	cell wall macromolecule metabolic process (GO:0044036)	4.76726003
33	rRNA methylation (GO:0031167)	4.76314544
34	calcium ion-dependent exocytosis (GO:0017156)	4.68205377
35	motile cilium assembly (GO:0044458)	4.59910182
36	cilium movement (GO:0003341)	4.57099551
37	protein localization to Golgi apparatus (GO:0034067)	4.55459518
38	binding of sperm to zona pellucida (GO:0007339)	4.55219045
39	spermatogenesis (GO:0007283)	4.46759691
40	male gamete generation (GO:0048232)	4.45757397
41	ketone body metabolic process (GO:1902224)	4.35459767
42	centriole assembly (GO:0098534)	4.33231541
43	RNA destabilization (GO:0050779)	4.30729207
44	single fertilization (GO:0007338)	4.20740899
45	positive regulation of Rab GTPase activity (GO:0032851)	4.16243121
46	regulation of Rab GTPase activity (GO:0032313)	4.16243121
47	gamete generation (GO:0007276)	4.12099003
48	seminiferous tubule development (GO:0072520)	4.09185761
49	regulation of microtubule-based movement (GO:0060632)	3.90085245
50	rRNA modification (GO:0000154)	3.82840642
51	regulation of transcription involved in cell fate commitment (GO:0060850)	3.77167320
52	germ cell development (GO:0007281)	3.72026733
53	microtubule severing (GO:0051013)	3.70121070
54	negative regulation of inclusion body assembly (GO:0090084)	3.63201992
55	regulation of centriole replication (GO:0046599)	3.60531680
56	fertilization (GO:0009566)	3.54986196
57	cilium organization (GO:0044782)	3.52069375
58	organic cation transport (GO:0015695)	3.48031024
59	cilium assembly (GO:0042384)	3.44848462
60	coenzyme catabolic process (GO:0009109)	3.44660259
61	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.40941578
62	negative regulation of Rho protein signal transduction (GO:0035024)	3.36870549
63	axoneme assembly (GO:0035082)	3.36772339
64	sexual reproduction (GO:0019953)	3.35122757
65	fucose catabolic process (GO:0019317)	3.26470174
66	L-fucose metabolic process (GO:0042354)	3.26470174
67	L-fucose catabolic process (GO:0042355)	3.26470174
68	multicellular organismal reproductive process (GO:0048609)	3.23296136
69	DNA methylation involved in gamete generation (GO:0043046)	3.23070904
70	cAMP catabolic process (GO:0006198)	3.17861067
71	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.12905657
72	regulation of translation, ncRNA-mediated (GO:0045974)	3.12905657
73	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.12905657
74	histone mRNA catabolic process (GO:0071044)	3.10376534
75	piRNA metabolic process (GO:0034587)	3.08877038
76	male meiosis (GO:0007140)	3.08771693
77	histone H3-K9 methylation (GO:0051567)	3.01253092
78	peptidyl-threonine dephosphorylation (GO:0035970)	3.00338813
79	male meiosis I (GO:0007141)	2.99371183
80	nucleus organization (GO:0006997)	2.96958759
81	chromatin silencing (GO:0006342)	2.94597727
82	ventricular system development (GO:0021591)	2.92980422
83	multicellular organismal movement (GO:0050879)	2.92235471
84	musculoskeletal movement (GO:0050881)	2.92235471
85	microtubule nucleation (GO:0007020)	2.90936031
86	spinal cord motor neuron differentiation (GO:0021522)	2.89236433
87	Golgi to endosome transport (GO:0006895)	2.86192750
88	cyclic nucleotide catabolic process (GO:0009214)	2.84542546
89	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.78948607
90	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.78624275
91	photoreceptor cell maintenance (GO:0045494)	2.77981885
92	retinal cone cell development (GO:0046549)	2.74697683
93	intra-Golgi vesicle-mediated transport (GO:0006891)	2.70735622
94	cellular component assembly involved in morphogenesis (GO:0010927)	2.62720592
95	histone H3-K9 modification (GO:0061647)	2.60303301
96	positive regulation of action potential (GO:0045760)	2.60037599
97	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.59939671
98	cell recognition (GO:0008037)	2.53201245
99	NAD biosynthetic process (GO:0009435)	2.52089831
100	positive regulation of guanylate cyclase activity (GO:0031284)	2.50470736

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.27753511
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.83782124
3	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.69743970
4	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.60139994
5	FUS_26573619_Chip-Seq_HEK293_Human	2.59334694
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.44444125
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.44420138
8	VDR_22108803_ChIP-Seq_LS180_Human	2.42160178
9	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.36797420
10	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.36797420
11	ER_23166858_ChIP-Seq_MCF-7_Human	2.35395756
12	CBP_20019798_ChIP-Seq_JUKART_Human	2.34847280
13	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.34847280
14	EZH2_22144423_ChIP-Seq_EOC_Human	2.29456230
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.21643417
16	P300_19829295_ChIP-Seq_ESCs_Human	2.10320564
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.05458740
18	IGF1R_20145208_ChIP-Seq_DFB_Human	2.02949759
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.00489395
20	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.96381981
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.96007034
22	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.89914315
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.84107990
24	AR_21572438_ChIP-Seq_LNCaP_Human	1.77215710
25	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.75534133
26	AR_25329375_ChIP-Seq_VCAP_Human	1.71056558
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.67055459
28	STAT3_23295773_ChIP-Seq_U87_Human	1.66848375
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.64762057
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61711088
31	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.60179036
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.58029936
33	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.56110585
34	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.52500582
35	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.50188090
36	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.46464600
37	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.46399009
38	RUNX2_22187159_ChIP-Seq_PCA_Human	1.46014126
39	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.44482731
40	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.43933840
41	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43915526
42	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43915526
43	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.42367399
44	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.42250935
45	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.37067644
46	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.36239574
47	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.35930748
48	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.35748011
49	TCF4_23295773_ChIP-Seq_U87_Human	1.34642438
50	ERA_21632823_ChIP-Seq_H3396_Human	1.33510673
51	EWS_26573619_Chip-Seq_HEK293_Human	1.33467302
52	NANOG_20526341_ChIP-Seq_ESCs_Human	1.30360883
53	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.29106892
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.28170804
55	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.27719987
56	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.27605731
57	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.27439186
58	TBL1_22424771_ChIP-Seq_293T_Human	1.25078001
59	ETV1_20927104_ChIP-Seq_GIST48_Human	1.24805377
60	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.24599480
61	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.22088172
62	MYC_19829295_ChIP-Seq_ESCs_Human	1.20919707
63	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.19922265
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18872341
65	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.18818929
66	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.18714362
67	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.16787901
68	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.16401104
69	NFYB_21822215_ChIP-Seq_K562_Human	1.15324349
70	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.14475031
71	RBPJ_21746931_ChIP-Seq_IB4_Human	1.14402770
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13471625
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13471625
74	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.13433194
75	DROSHA_22980978_ChIP-Seq_HELA_Human	1.12465133
76	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.12208820
77	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.11819158
78	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.11782065
79	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.11234195
80	HOXB7_26014856_ChIP-Seq_BT474_Human	1.11144049
81	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10888524
82	RAC3_21632823_ChIP-Seq_H3396_Human	1.10808521
83	OCT4_20526341_ChIP-Seq_ESCs_Human	1.10734290
84	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10237512
85	PHF8_20622853_ChIP-Seq_HELA_Human	1.09805452
86	NCOR_22424771_ChIP-Seq_293T_Human	1.06912313
87	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.06487132
88	BCAT_22108803_ChIP-Seq_LS180_Human	1.06134676
89	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.06098765
90	TCF4_22108803_ChIP-Seq_LS180_Human	1.05582846
91	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.05567443
92	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.05222992
93	REST_21632747_ChIP-Seq_MESCs_Mouse	1.04812498
94	KDM2B_26808549_Chip-Seq_REH_Human	1.04434983
95	NFYA_21822215_ChIP-Seq_K562_Human	1.04418946
96	IRF1_19129219_ChIP-ChIP_H3396_Human	1.03625985
97	TP53_18474530_ChIP-ChIP_U2OS_Human	1.03591077
98	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03433754
99	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.03229148
100	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.03185642

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	8.13560063
2	MP0003698_abnormal_male_reproductive	3.34644096
3	MP0003878_abnormal_ear_physiology	3.08760089
4	MP0005377_hearing/vestibular/ear_phenot	3.08760089
5	MP0001929_abnormal_gametogenesis	3.04179325
6	MP0003787_abnormal_imprinting	2.98047030
7	MP0000569_abnormal_digit_pigmentation	2.82234266
8	MP0008877_abnormal_DNA_methylation	2.80873432
9	MP0002735_abnormal_chemical_nociception	2.12492968
10	MP0005253_abnormal_eye_physiology	2.06638598
11	MP0005551_abnormal_eye_electrophysiolog	1.97706873
12	MP0005670_abnormal_white_adipose	1.97215401
13	MP0003718_maternal_effect	1.96981402
14	MP0002234_abnormal_pharynx_morphology	1.76956534
15	MP0001986_abnormal_taste_sensitivity	1.70848659
16	MP0008789_abnormal_olfactory_epithelium	1.69560203
17	MP0002161_abnormal_fertility/fecundity	1.66849068
18	MP0006072_abnormal_retinal_apoptosis	1.63931771
19	MP0008057_abnormal_DNA_replication	1.61628617
20	MP0001486_abnormal_startle_reflex	1.57816978
21	MP0003646_muscle_fatigue	1.54529759
22	MP0001968_abnormal_touch/_nociception	1.47529430
23	MP0001485_abnormal_pinna_reflex	1.45246677
24	MP0002102_abnormal_ear_morphology	1.44769079
25	MP0005499_abnormal_olfactory_system	1.42292810
26	MP0005394_taste/olfaction_phenotype	1.42292810
27	MP0002210_abnormal_sex_determination	1.41348341
28	MP0002132_abnormal_respiratory_system	1.36667570
29	MP0009697_abnormal_copulation	1.34958889
30	MP0003011_delayed_dark_adaptation	1.31240374
31	MP0005379_endocrine/exocrine_gland_phen	1.28235322
32	MP0002837_dystrophic_cardiac_calcinosis	1.27013621
33	MP0003195_calcinosis	1.26457493
34	MP0000516_abnormal_urinary_system	1.24275754
35	MP0005367_renal/urinary_system_phenotyp	1.24275754
36	MP0009046_muscle_twitch	1.23654388
37	MP0000653_abnormal_sex_gland	1.21349885
38	MP0001145_abnormal_male_reproductive	1.17423893
39	MP0006292_abnormal_olfactory_placode	1.17161914
40	MP0004742_abnormal_vestibular_system	1.15485929
41	MP0002009_preneoplasia	1.12189907
42	MP0008058_abnormal_DNA_repair	1.10918801
43	MP0001348_abnormal_lacrimal_gland	1.07121409
44	MP0002653_abnormal_ependyma_morphology	1.06812787
45	MP0002282_abnormal_trachea_morphology	1.05789979
46	MP0005084_abnormal_gallbladder_morpholo	1.05301836
47	MP0002067_abnormal_sensory_capabilities	1.03868734
48	MP0002928_abnormal_bile_duct	1.02395984
49	MP0002822_catalepsy	1.01222722
50	MP0004885_abnormal_endolymph	1.00188410
51	MP0005423_abnormal_somatic_nervous	0.99208160
52	MP0009745_abnormal_behavioral_response	0.99138493
53	MP0002127_abnormal_cardiovascular_syste	0.98929793
54	MP0002229_neurodegeneration	0.96569927
55	MP0001984_abnormal_olfaction	0.95873606
56	MP0003136_yellow_coat_color	0.95755153
57	MP0008995_early_reproductive_senescence	0.95585844
58	MP0001501_abnormal_sleep_pattern	0.94677311
59	MP0001764_abnormal_homeostasis	0.94630703
60	MP0000026_abnormal_inner_ear	0.94595187
61	MP0003121_genomic_imprinting	0.94101995
62	MP0005391_vision/eye_phenotype	0.93668667
63	MP0005386_behavior/neurological_phenoty	0.93661972
64	MP0004924_abnormal_behavior	0.93661972
65	MP0000955_abnormal_spinal_cord	0.93215991
66	MP0005248_abnormal_Harderian_gland	0.92721210
67	MP0004484_altered_response_of	0.91915583
68	MP0001963_abnormal_hearing_physiology	0.89313794
69	MP0005645_abnormal_hypothalamus_physiol	0.88033362
70	MP0000631_abnormal_neuroendocrine_gland	0.87573206
71	MP0003880_abnormal_central_pattern	0.86125552
72	MP0002272_abnormal_nervous_system	0.85792877
73	MP0002557_abnormal_social/conspecific_i	0.85362175
74	MP0005646_abnormal_pituitary_gland	0.85212355
75	MP0005195_abnormal_posterior_eye	0.82785537
76	MP0005395_other_phenotype	0.82526002
77	MP0005451_abnormal_body_composition	0.82202843
78	MP0004133_heterotaxia	0.81564320
79	MP0000372_irregular_coat_pigmentation	0.80452990
80	MP0004142_abnormal_muscle_tone	0.79092510
81	MP0001529_abnormal_vocalization	0.78529351
82	MP0002572_abnormal_emotion/affect_behav	0.76005552
83	MP0005167_abnormal_blood-brain_barrier	0.75760423
84	MP0005310_abnormal_salivary_gland	0.75218212
85	MP0009053_abnormal_anal_canal	0.74669106
86	MP0001905_abnormal_dopamine_level	0.74240797
87	MP0000427_abnormal_hair_cycle	0.74061863
88	MP0009764_decreased_sensitivity_to	0.72058815
89	MP0000049_abnormal_middle_ear	0.71754760
90	MP0005083_abnormal_biliary_tract	0.71661641
91	MP0003119_abnormal_digestive_system	0.68887284
92	MP0004085_abnormal_heartbeat	0.68068973
93	MP0009115_abnormal_fat_cell	0.67898622
94	MP0004084_abnormal_cardiac_muscle	0.66362160
95	MP0000015_abnormal_ear_pigmentation	0.66180635
96	MP0000678_abnormal_parathyroid_gland	0.66131731
97	MP0001324_abnormal_eye_pigmentation	0.65930210
98	MP0008961_abnormal_basal_metabolism	0.65878584
99	MP0008775_abnormal_heart_ventricle	0.65859785
100	MP0001765_abnormal_ion_homeostasis	0.64933011

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.33372387
2	Absent/shortened dynein arms (HP:0200106)	5.33372387
3	Chronic hepatic failure (HP:0100626)	5.08053664
4	Severe visual impairment (HP:0001141)	4.71756559
5	Abnormal respiratory motile cilium morphology (HP:0005938)	4.40966117
6	Abnormal respiratory epithelium morphology (HP:0012253)	4.40966117
7	Abnormal ciliary motility (HP:0012262)	4.35039717
8	Attenuation of retinal blood vessels (HP:0007843)	4.20820680
9	Nephronophthisis (HP:0000090)	4.06742258
10	Abnormal respiratory motile cilium physiology (HP:0012261)	3.99473299
11	Pancreatic fibrosis (HP:0100732)	3.99464307
12	Tubulointerstitial nephritis (HP:0001970)	3.89692789
13	Pancreatic cysts (HP:0001737)	3.86252897
14	Bony spicule pigmentary retinopathy (HP:0007737)	3.58269183
15	Abnormality of the renal medulla (HP:0100957)	3.55727444
16	Abnormal rod and cone electroretinograms (HP:0008323)	3.53181830
17	True hermaphroditism (HP:0010459)	3.45218697
18	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.32566483
19	Molar tooth sign on MRI (HP:0002419)	2.98739170
20	Abnormality of midbrain morphology (HP:0002418)	2.98739170
21	Abnormality of macular pigmentation (HP:0008002)	2.94127055
22	Hypoplastic ischia (HP:0003175)	2.88971538
23	Abnormal drinking behavior (HP:0030082)	2.83015486
24	Polydipsia (HP:0001959)	2.83015486
25	Progressive cerebellar ataxia (HP:0002073)	2.77527319
26	Bell-shaped thorax (HP:0001591)	2.77356549
27	Occipital encephalocele (HP:0002085)	2.62331456
28	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.60879157
29	Rhinitis (HP:0012384)	2.59293443
30	Hyperkalemia (HP:0002153)	2.57863986
31	Abnormality of the renal cortex (HP:0011035)	2.56076820
32	Type II lissencephaly (HP:0007260)	2.52776677
33	Abnormality of the ischium (HP:0003174)	2.52628317
34	Infertility (HP:0000789)	2.46537584
35	Cystic liver disease (HP:0006706)	2.45077630
36	Congenital hepatic fibrosis (HP:0002612)	2.43433256
37	Medial flaring of the eyebrow (HP:0010747)	2.41571142
38	Polyuria (HP:0000103)	2.40642066
39	Tubular atrophy (HP:0000092)	2.36118228
40	Anencephaly (HP:0002323)	2.33307961
41	Truncal obesity (HP:0001956)	2.29113146
42	Inability to walk (HP:0002540)	2.28426943
43	Abnormal urine output (HP:0012590)	2.28024175
44	Bulbous nose (HP:0000414)	2.25659239
45	Cone-rod dystrophy (HP:0000548)	2.24431702
46	Congenital stationary night blindness (HP:0007642)	2.24104999
47	Cerebellar dysplasia (HP:0007033)	2.23662085
48	Tubulointerstitial abnormality (HP:0001969)	2.20277102
49	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.18615565
50	Postaxial foot polydactyly (HP:0001830)	2.18583926
51	Hypoalphalipoproteinemia (HP:0003233)	2.16604153
52	Febrile seizures (HP:0002373)	2.16255314
53	Impulsivity (HP:0100710)	2.14255757
54	Azoospermia (HP:0000027)	2.12758076
55	Pendular nystagmus (HP:0012043)	2.12148287
56	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.11777771
57	Optic nerve hypoplasia (HP:0000609)	2.10410561
58	Decreased central vision (HP:0007663)	2.06316102
59	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.05743605
60	Sclerocornea (HP:0000647)	2.04115097
61	Gait imbalance (HP:0002141)	2.04027760
62	Resting tremor (HP:0002322)	2.02586157
63	Hyperventilation (HP:0002883)	2.01796193
64	Bile duct proliferation (HP:0001408)	2.01162229
65	Abnormal biliary tract physiology (HP:0012439)	2.01162229
66	Stage 5 chronic kidney disease (HP:0003774)	2.00644282
67	Asymmetric septal hypertrophy (HP:0001670)	2.00592701
68	Amelogenesis imperfecta (HP:0000705)	2.00450136
69	Atonic seizures (HP:0010819)	2.00102905
70	Abnormal spermatogenesis (HP:0008669)	1.99168611
71	Congenital primary aphakia (HP:0007707)	1.97695351
72	Enlarged epiphyses (HP:0010580)	1.95007748
73	Postural instability (HP:0002172)	1.94023051
74	Potter facies (HP:0002009)	1.93753467
75	Facial shape deformation (HP:0011334)	1.93753467
76	Poor coordination (HP:0002370)	1.93343500
77	Bronchiectasis (HP:0002110)	1.89293483
78	Renal dysplasia (HP:0000110)	1.89228936
79	Genital tract atresia (HP:0001827)	1.88052978
80	Abnormality of the pubic bones (HP:0003172)	1.87627411
81	Widely spaced teeth (HP:0000687)	1.84816357
82	Abnormality of DNA repair (HP:0003254)	1.83533504
83	Male pseudohermaphroditism (HP:0000037)	1.81099690
84	Absent speech (HP:0001344)	1.80780762
85	Nasal polyposis (HP:0100582)	1.79891510
86	Photophobia (HP:0000613)	1.79065767
87	Type II diabetes mellitus (HP:0005978)	1.78504054
88	Intestinal atresia (HP:0011100)	1.78003725
89	Portal hypertension (HP:0001409)	1.77929933
90	Hypoplastic iliac wings (HP:0002866)	1.77691256
91	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.77576610
92	Abnormality of renal excretion (HP:0011036)	1.77304612
93	Sloping forehead (HP:0000340)	1.75755839
94	Retinal dysplasia (HP:0007973)	1.75496941
95	Nephrogenic diabetes insipidus (HP:0009806)	1.74413944
96	Astigmatism (HP:0000483)	1.74256488
97	Hypochromic microcytic anemia (HP:0004840)	1.74063648
98	Gaze-evoked nystagmus (HP:0000640)	1.73652196
99	Congenital malformation of the right heart (HP:0011723)	1.73164705
100	Double outlet right ventricle (HP:0001719)	1.73164705

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	4.99584301
2	INSRR	4.55470946
3	FRK	3.92259289
4	MAP4K2	3.52102428
5	BMPR1B	3.20310661
6	ACVR1B	2.72702910
7	PINK1	2.68029227
8	AKT3	2.38028439
9	PNCK	2.14989549
10	PLK2	2.07118172
11	STK38	1.98851174
12	STK38L	1.89745127
13	MAPK15	1.89335493
14	BRD4	1.84116894
15	MAP3K4	1.82125095
16	TLK1	1.77777113
17	TAOK3	1.76839037
18	NTRK2	1.70783355
19	RIPK1	1.67760706
20	NUAK1	1.61029442
21	PTK2B	1.55900065
22	DDR2	1.54142366
23	TNIK	1.53624427
24	WNK3	1.51748191
25	ADRBK2	1.49966865
26	ZAK	1.44369992
27	DYRK3	1.36748134
28	TESK1	1.35302357
29	MAPK13	1.24119198
30	IRAK1	1.22360596
31	CAMK1G	1.17399350
32	BRSK2	1.13615427
33	GRK1	1.08648367
34	TGFBR1	1.08017104
35	MAP2K7	1.01784604
36	TIE1	0.96091402
37	PIK3CG	0.94715457
38	CDK3	0.89389614
39	CASK	0.88252516
40	NTRK3	0.85139590
41	LATS1	0.84466937
42	WNK1	0.82479168
43	MKNK2	0.79028316
44	CAMKK2	0.76151291
45	OXSR1	0.75404255
46	TRIM28	0.73094912
47	PRKAA2	0.68764583
48	MARK3	0.67300344
49	STK39	0.67088566
50	WNK4	0.67011178
51	SGK2	0.63372940
52	PRKG1	0.61089625
53	MARK1	0.56246004
54	PAK3	0.53975092
55	PDK1	0.53594252
56	PRKCE	0.52666247
57	CAMK1D	0.52119942
58	DYRK1B	0.51769925
59	BLK	0.50949793
60	TNK2	0.50482022
61	NEK2	0.49849704
62	SIK2	0.47011272
63	FGFR2	0.46837908
64	VRK1	0.46726662
65	SGK494	0.45771352
66	SGK223	0.45771352
67	TEC	0.45619680
68	PRKCG	0.45369704
69	DAPK2	0.43711165
70	NEK6	0.42377231
71	KSR2	0.41423596
72	PHKG1	0.41349952
73	PHKG2	0.41349952
74	MKNK1	0.41278513
75	PRKAA1	0.40312357
76	OBSCN	0.40055422
77	FLT3	0.39449335
78	CDK12	0.38889376
79	IKBKB	0.38573726
80	MAP3K7	0.38347158
81	MAP3K2	0.38075909
82	MUSK	0.36834329
83	MELK	0.36709302
84	KIT	0.36380805
85	JAK3	0.36115749
86	CSNK1A1L	0.35441163
87	CHUK	0.35163144
88	CAMK4	0.33780259
89	PRKCQ	0.32869756
90	NLK	0.31137710
91	YES1	0.30858742
92	PDPK1	0.29190353
93	CDK7	0.28807351
94	ADRBK1	0.28284417
95	EIF2AK3	0.27998525
96	RPS6KA1	0.27533247
97	RPS6KA5	0.26807323
98	SGK1	0.25059605
99	CAMK2A	0.24819024
100	TXK	0.24770073

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.76016953
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.44255036
3	Butanoate metabolism_Homo sapiens_hsa00650	3.33581089
4	Olfactory transduction_Homo sapiens_hsa04740	3.28775065
5	Selenocompound metabolism_Homo sapiens_hsa00450	2.63562707
6	Phototransduction_Homo sapiens_hsa04744	2.62927192
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.60555464
8	Taste transduction_Homo sapiens_hsa04742	2.17258196
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.13028928
10	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.01480934
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.97464252
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.91422926
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.81191386
14	Nicotine addiction_Homo sapiens_hsa05033	1.80088197
15	ABC transporters_Homo sapiens_hsa02010	1.75135097
16	Basal transcription factors_Homo sapiens_hsa03022	1.66616621
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.64829187
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.56723693
19	Circadian rhythm_Homo sapiens_hsa04710	1.54560357
20	Morphine addiction_Homo sapiens_hsa05032	1.51584251
21	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.46911861
22	Regulation of autophagy_Homo sapiens_hsa04140	1.44037044
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.39155119
24	Homologous recombination_Homo sapiens_hsa03440	1.38385092
25	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.37673452
26	Caffeine metabolism_Homo sapiens_hsa00232	1.35104420
27	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.31191136
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.13600288
29	Circadian entrainment_Homo sapiens_hsa04713	1.04869576
30	Type II diabetes mellitus_Homo sapiens_hsa04930	1.04546121
31	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.00876079
32	Propanoate metabolism_Homo sapiens_hsa00640	0.97667886
33	RNA transport_Homo sapiens_hsa03013	0.97269745
34	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.95415529
35	Fatty acid metabolism_Homo sapiens_hsa01212	0.92957480
36	Tryptophan metabolism_Homo sapiens_hsa00380	0.92743792
37	Insulin secretion_Homo sapiens_hsa04911	0.92215898
38	Calcium signaling pathway_Homo sapiens_hsa04020	0.91781005
39	Salivary secretion_Homo sapiens_hsa04970	0.91259988
40	Type I diabetes mellitus_Homo sapiens_hsa04940	0.90099696
41	GABAergic synapse_Homo sapiens_hsa04727	0.87354846
42	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.87201816
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.87010321
44	Ether lipid metabolism_Homo sapiens_hsa00565	0.86282368
45	cAMP signaling pathway_Homo sapiens_hsa04024	0.83538401
46	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.83456096
47	RNA degradation_Homo sapiens_hsa03018	0.83090690
48	Peroxisome_Homo sapiens_hsa04146	0.82903753
49	Serotonergic synapse_Homo sapiens_hsa04726	0.82735931
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.76726164
51	Purine metabolism_Homo sapiens_hsa00230	0.75458430
52	Glutamatergic synapse_Homo sapiens_hsa04724	0.72498798
53	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.71910682
54	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.71216600
55	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.70888027
56	Non-homologous end-joining_Homo sapiens_hsa03450	0.67904293
57	Fatty acid degradation_Homo sapiens_hsa00071	0.67525270
58	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.66439999
59	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.65559168
60	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.64017117
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63432558
62	Oocyte meiosis_Homo sapiens_hsa04114	0.62861428
63	Retinol metabolism_Homo sapiens_hsa00830	0.62225897
64	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.61701403
65	Renin secretion_Homo sapiens_hsa04924	0.55612506
66	Lysine degradation_Homo sapiens_hsa00310	0.55084221
67	Graft-versus-host disease_Homo sapiens_hsa05332	0.54356905
68	Sphingolipid metabolism_Homo sapiens_hsa00600	0.53515587
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.52956158
70	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.50562020
71	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50073201
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.49563498
73	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.48774158
74	One carbon pool by folate_Homo sapiens_hsa00670	0.46842980
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.43065397
76	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.42987972
77	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.42265537
78	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.41579323
79	Allograft rejection_Homo sapiens_hsa05330	0.41528287
80	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.40193566
81	Cardiac muscle contraction_Homo sapiens_hsa04260	0.39217308
82	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.38426581
83	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.37639856
84	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.35462132
85	FoxO signaling pathway_Homo sapiens_hsa04068	0.34192389
86	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.32776864
87	Cholinergic synapse_Homo sapiens_hsa04725	0.32301295
88	Protein export_Homo sapiens_hsa03060	0.32099896
89	Huntingtons disease_Homo sapiens_hsa05016	0.32021555
90	Metabolic pathways_Homo sapiens_hsa01100	0.31840801
91	RNA polymerase_Homo sapiens_hsa03020	0.29783442
92	Alcoholism_Homo sapiens_hsa05034	0.29472527
93	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.28838396
94	MAPK signaling pathway_Homo sapiens_hsa04010	0.28606940
95	Amphetamine addiction_Homo sapiens_hsa05031	0.27369357
96	Long-term depression_Homo sapiens_hsa04730	0.26595245
97	Antigen processing and presentation_Homo sapiens_hsa04612	0.25992685
98	Insulin resistance_Homo sapiens_hsa04931	0.25150137
99	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.24439784
100	Estrogen signaling pathway_Homo sapiens_hsa04915	0.21463689

LINC01347

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »