ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.78830618
2	ATP synthesis coupled proton transport (GO:0015986)	6.14738489
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.14738489
4	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.96621380
5	protein complex biogenesis (GO:0070271)	5.42875442
6	respiratory electron transport chain (GO:0022904)	5.32165079
7	electron transport chain (GO:0022900)	5.25237849
8	mitochondrial respiratory chain complex assembly (GO:0033108)	4.96301401
9	chaperone-mediated protein transport (GO:0072321)	4.95701730
10	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.91505210
11	NADH dehydrogenase complex assembly (GO:0010257)	4.91505210
12	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.91505210
13	protein neddylation (GO:0045116)	4.85235209
14	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.81382032
15	respiratory chain complex IV assembly (GO:0008535)	4.27312008
16	cytochrome complex assembly (GO:0017004)	4.11792694
17	ribosomal small subunit assembly (GO:0000028)	3.92885948
18	cullin deneddylation (GO:0010388)	3.88709195
19	proteasome assembly (GO:0043248)	3.80758040
20	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.79140707
21	cotranslational protein targeting to membrane (GO:0006613)	3.77897184
22	viral transcription (GO:0019083)	3.76440952
23	hydrogen ion transmembrane transport (GO:1902600)	3.74413059
24	protein targeting to ER (GO:0045047)	3.72982247
25	translational termination (GO:0006415)	3.71312336
26	platelet dense granule organization (GO:0060155)	3.67753420
27	water-soluble vitamin biosynthetic process (GO:0042364)	3.67246537
28	sequestering of actin monomers (GO:0042989)	3.66829257
29	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.64682612
30	protein deneddylation (GO:0000338)	3.61056728
31	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.60695897
32	protein localization to endoplasmic reticulum (GO:0070972)	3.57855505
33	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.57830866
34	termination of RNA polymerase III transcription (GO:0006386)	3.57830866
35	ATP biosynthetic process (GO:0006754)	3.55681512
36	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.52964965
37	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.51842998
38	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.51105219
39	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.50936339
40	regulation of mitochondrial translation (GO:0070129)	3.49248193
41	proton transport (GO:0015992)	3.44067790
42	hydrogen transport (GO:0006818)	3.37966025
43	GTP biosynthetic process (GO:0006183)	3.36613625
44	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.32583350
45	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.28249222
46	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.28249222
47	translational elongation (GO:0006414)	3.19248523
48	DNA deamination (GO:0045006)	3.12154025
49	translation (GO:0006412)	3.04029142
50	ribosomal small subunit biogenesis (GO:0042274)	3.03586995
51	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.03228893
52	mannosylation (GO:0097502)	3.01549189
53	protein localization to cilium (GO:0061512)	2.99596125
54	epithelial cilium movement (GO:0003351)	2.93352341
55	protein targeting to mitochondrion (GO:0006626)	2.93100417
56	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.92377629
57	DNA damage response, detection of DNA damage (GO:0042769)	2.92085563
58	protein-cofactor linkage (GO:0018065)	2.91740542
59	intraciliary transport (GO:0042073)	2.90621096
60	aldehyde catabolic process (GO:0046185)	2.89216965
61	regulation of cilium movement (GO:0003352)	2.88792531
62	intracellular protein transmembrane import (GO:0044743)	2.87598940
63	nucleoside triphosphate biosynthetic process (GO:0009142)	2.86422870
64	behavioral response to nicotine (GO:0035095)	2.84950660
65	viral life cycle (GO:0019058)	2.83378805
66	nonmotile primary cilium assembly (GO:0035058)	2.82157921
67	establishment of protein localization to mitochondrion (GO:0072655)	2.81693266
68	regulation of cellular amino acid metabolic process (GO:0006521)	2.80449037
69	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.80423840
70	protein localization to mitochondrion (GO:0070585)	2.79484504
71	spliceosomal snRNP assembly (GO:0000387)	2.78459547
72	oxidative phosphorylation (GO:0006119)	2.77309843
73	cellular protein complex disassembly (GO:0043624)	2.77290982
74	translational initiation (GO:0006413)	2.74273418
75	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.73794380
76	pyrimidine nucleotide catabolic process (GO:0006244)	2.72127012
77	maturation of SSU-rRNA (GO:0030490)	2.72038814
78	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.70456653
79	inner mitochondrial membrane organization (GO:0007007)	2.68285755
80	ribosomal large subunit biogenesis (GO:0042273)	2.67426161
81	UTP biosynthetic process (GO:0006228)	2.65329394
82	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.64638349
83	DNA double-strand break processing (GO:0000729)	2.64407265
84	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.62789321
85	anterograde synaptic vesicle transport (GO:0048490)	2.60729983
86	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.60458396
87	negative regulation of ligase activity (GO:0051352)	2.60458396
88	preassembly of GPI anchor in ER membrane (GO:0016254)	2.57878789
89	peptidyl-histidine modification (GO:0018202)	2.57721902
90	C-terminal protein lipidation (GO:0006501)	2.57316266
91	base-excision repair, AP site formation (GO:0006285)	2.57121290
92	rRNA modification (GO:0000154)	2.56697721
93	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.56330394
94	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.56330394
95	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.56330394
96	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.55143553
97	spliceosomal complex assembly (GO:0000245)	2.55082546
98	cellular component biogenesis (GO:0044085)	2.54996290
99	UTP metabolic process (GO:0046051)	2.54366166
100	mitochondrial transport (GO:0006839)	2.52616870

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.36662525
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.22481134
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.91574153
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.35543429
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.34548441
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.17419213
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.77624726
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.71622497
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.70764450
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.60996562
11	ELK1_19687146_ChIP-ChIP_HELA_Human	2.56269381
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.35501900
13	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.29667755
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.27727091
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.27253510
16	FUS_26573619_Chip-Seq_HEK293_Human	2.17009987
17	EWS_26573619_Chip-Seq_HEK293_Human	2.05693779
18	VDR_22108803_ChIP-Seq_LS180_Human	2.04909824
19	IGF1R_20145208_ChIP-Seq_DFB_Human	2.02766617
20	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.99028342
21	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.96364026
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.93064528
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.89947658
24	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.86370337
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.83513479
26	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.80938188
27	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.77194163
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.74089790
29	P300_19829295_ChIP-Seq_ESCs_Human	1.66047167
30	GBX2_23144817_ChIP-Seq_PC3_Human	1.64279771
31	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.62208955
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.61447031
33	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.61038519
34	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.59913768
35	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.58221639
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.50707798
37	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.49156837
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47078007
39	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.42767099
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.40494751
41	TTF2_22483619_ChIP-Seq_HELA_Human	1.40283548
42	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.38341536
43	EZH2_22144423_ChIP-Seq_EOC_Human	1.38113868
44	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.36146821
45	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.36135707
46	IRF1_19129219_ChIP-ChIP_H3396_Human	1.35300085
47	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.33671354
48	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.30775683
49	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.28111196
50	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.27744333
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25876186
52	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.25586585
53	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.25322137
54	DCP1A_22483619_ChIP-Seq_HELA_Human	1.23604137
55	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.22235686
56	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.21705485
57	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.21629845
58	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.20648852
59	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.20566556
60	GABP_19822575_ChIP-Seq_HepG2_Human	1.19616602
61	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16817343
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16817343
63	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.16314024
64	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.14800501
65	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.14714850
66	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.14714850
67	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.13298139
68	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13230682
69	RNF2_27304074_Chip-Seq_NSC_Mouse	1.13005876
70	HTT_18923047_ChIP-ChIP_STHdh_Human	1.13004687
71	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.12171436
72	CBP_20019798_ChIP-Seq_JUKART_Human	1.12171436
73	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.10965651
74	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.05378017
75	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.04216070
76	BCAT_22108803_ChIP-Seq_LS180_Human	1.01224431
77	AR_20517297_ChIP-Seq_VCAP_Human	1.00891470
78	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.00862500
79	ER_23166858_ChIP-Seq_MCF-7_Human	1.00347413
80	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00335587
81	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.99915145
82	NCOR_22424771_ChIP-Seq_293T_Human	0.99476602
83	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.97419046
84	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.97322000
85	XRN2_22483619_ChIP-Seq_HELA_Human	0.97201526
86	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.97019473
87	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.94592999
88	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.93864779
89	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.93607708
90	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.92094396
91	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.91295090
92	AR_25329375_ChIP-Seq_VCAP_Human	0.90678894
93	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.90418065
94	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.89249613
95	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.89233820
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.86927358
97	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.86325646
98	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.86320775
99	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.84385662
100	SMAD4_21799915_ChIP-Seq_A2780_Human	0.84251395

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006072_abnormal_retinal_apoptosis	2.84462633
2	MP0006292_abnormal_olfactory_placode	2.79294811
3	MP0003880_abnormal_central_pattern	2.77109979
4	MP0002837_dystrophic_cardiac_calcinosis	2.54685890
5	MP0003787_abnormal_imprinting	2.46075021
6	MP0001529_abnormal_vocalization	2.36446785
7	MP0008877_abnormal_DNA_methylation	2.28476043
8	MP0002102_abnormal_ear_morphology	2.27817092
9	MP0009379_abnormal_foot_pigmentation	2.24089269
10	MP0006276_abnormal_autonomic_nervous	2.17526713
11	MP0003122_maternal_imprinting	2.16984614
12	MP0001984_abnormal_olfaction	2.10611016
13	MP0001968_abnormal_touch/_nociception	2.07821394
14	MP0005084_abnormal_gallbladder_morpholo	2.06718186
15	MP0003136_yellow_coat_color	2.04654439
16	MP0005646_abnormal_pituitary_gland	2.00939188
17	MP0008789_abnormal_olfactory_epithelium	1.99830925
18	MP0000372_irregular_coat_pigmentation	1.97414913
19	MP0003121_genomic_imprinting	1.96927399
20	MP0001905_abnormal_dopamine_level	1.89149862
21	MP0003011_delayed_dark_adaptation	1.84381891
22	MP0002938_white_spotting	1.83814722
23	MP0003186_abnormal_redox_activity	1.83669211
24	MP0002736_abnormal_nociception_after	1.81488886
25	MP0008058_abnormal_DNA_repair	1.81156005
26	MP0005253_abnormal_eye_physiology	1.75694417
27	MP0005551_abnormal_eye_electrophysiolog	1.72153727
28	MP0002163_abnormal_gland_morphology	1.70986480
29	MP0004142_abnormal_muscle_tone	1.70449151
30	MP0002653_abnormal_ependyma_morphology	1.67328148
31	MP0003195_calcinosis	1.66446363
32	MP0005645_abnormal_hypothalamus_physiol	1.64526244
33	MP0005394_taste/olfaction_phenotype	1.58699679
34	MP0005499_abnormal_olfactory_system	1.58699679
35	MP0009046_muscle_twitch	1.57335920
36	MP0006036_abnormal_mitochondrial_physio	1.56961440
37	MP0010386_abnormal_urinary_bladder	1.54973822
38	MP0005379_endocrine/exocrine_gland_phen	1.54602033
39	MP0003806_abnormal_nucleotide_metabolis	1.53650488
40	MP0004133_heterotaxia	1.52188954
41	MP0000631_abnormal_neuroendocrine_gland	1.51643160
42	MP0008995_early_reproductive_senescence	1.45467373
43	MP0002638_abnormal_pupillary_reflex	1.41495620
44	MP0001485_abnormal_pinna_reflex	1.40824901
45	MP0002272_abnormal_nervous_system	1.40783070
46	MP0003718_maternal_effect	1.37287697
47	MP0009745_abnormal_behavioral_response	1.32524700
48	MP0002735_abnormal_chemical_nociception	1.30503672
49	MP0002277_abnormal_respiratory_mucosa	1.30092800
50	MP0005075_abnormal_melanosome_morpholog	1.26245057
51	MP0009697_abnormal_copulation	1.26043425
52	MP0002822_catalepsy	1.24715743
53	MP0000516_abnormal_urinary_system	1.24141851
54	MP0005367_renal/urinary_system_phenotyp	1.24141851
55	MP0001188_hyperpigmentation	1.21711139
56	MP0001293_anophthalmia	1.19465788
57	MP0002751_abnormal_autonomic_nervous	1.18140159
58	MP0002734_abnormal_mechanical_nocicepti	1.16780637
59	MP0001970_abnormal_pain_threshold	1.16032798
60	MP0008872_abnormal_physiological_respon	1.10908252
61	MP0002733_abnormal_thermal_nociception	1.07507431
62	MP0008875_abnormal_xenobiotic_pharmacok	1.06443102
63	MP0002557_abnormal_social/conspecific_i	1.04524333
64	MP0002572_abnormal_emotion/affect_behav	1.04280979
65	MP0003786_premature_aging	0.99980975
66	MP0004147_increased_porphyrin_level	0.99875480
67	MP0004885_abnormal_endolymph	0.99402136
68	MP0002234_abnormal_pharynx_morphology	0.97972383
69	MP0006035_abnormal_mitochondrial_morpho	0.97959324
70	MP0002160_abnormal_reproductive_system	0.97948929
71	MP0002090_abnormal_vision	0.97854434
72	MP0005195_abnormal_posterior_eye	0.96918920
73	MP0002876_abnormal_thyroid_physiology	0.94389519
74	MP0001486_abnormal_startle_reflex	0.94250898
75	MP0002752_abnormal_somatic_nervous	0.94188140
76	MP0005410_abnormal_fertilization	0.90554496
77	MP0001324_abnormal_eye_pigmentation	0.89586007
78	MP0000026_abnormal_inner_ear	0.89214279
79	MP0002095_abnormal_skin_pigmentation	0.88627079
80	MP0000049_abnormal_middle_ear	0.88348088
81	MP0002928_abnormal_bile_duct	0.88052515
82	MP0005389_reproductive_system_phenotype	0.87309468
83	MP0000778_abnormal_nervous_system	0.87164566
84	MP0002067_abnormal_sensory_capabilities	0.86616996
85	MP0002184_abnormal_innervation	0.86353567
86	MP0002064_seizures	0.85990295
87	MP0010030_abnormal_orbit_morphology	0.84431635
88	MP0002233_abnormal_nose_morphology	0.84022480
89	MP0003137_abnormal_impulse_conducting	0.82553280
90	MP0001756_abnormal_urination	0.82476252
91	MP0001764_abnormal_homeostasis	0.81768269
92	MP0003693_abnormal_embryo_hatching	0.80034344
93	MP0005391_vision/eye_phenotype	0.79830683
94	MP0001963_abnormal_hearing_physiology	0.78143387
95	MP0005377_hearing/vestibular/ear_phenot	0.76537813
96	MP0003878_abnormal_ear_physiology	0.76537813
97	MP0002210_abnormal_sex_determination	0.75048651
98	MP0005174_abnormal_tail_pigmentation	0.74658701
99	MP0002909_abnormal_adrenal_gland	0.74039726
100	MP0002282_abnormal_trachea_morphology	0.73405622

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.42184033
2	Mitochondrial inheritance (HP:0001427)	4.90124424
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.79411812
4	Acute encephalopathy (HP:0006846)	4.70245153
5	Progressive macrocephaly (HP:0004481)	4.69855600
6	Increased CSF lactate (HP:0002490)	4.37894649
7	Hepatocellular necrosis (HP:0001404)	4.23955960
8	Increased hepatocellular lipid droplets (HP:0006565)	4.13331071
9	Hepatic necrosis (HP:0002605)	4.03424792
10	Lipid accumulation in hepatocytes (HP:0006561)	3.86432989
11	3-Methylglutaconic aciduria (HP:0003535)	3.83958440
12	Renal Fanconi syndrome (HP:0001994)	3.69097331
13	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.42253904
14	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.42253904
15	Cerebral edema (HP:0002181)	3.41547797
16	Pancreatic fibrosis (HP:0100732)	3.38684017
17	Pancreatic cysts (HP:0001737)	3.33140747
18	Abnormality of midbrain morphology (HP:0002418)	3.31312214
19	Molar tooth sign on MRI (HP:0002419)	3.31312214
20	Medial flaring of the eyebrow (HP:0010747)	3.24695105
21	True hermaphroditism (HP:0010459)	3.21410857
22	Optic disc pallor (HP:0000543)	3.04353074
23	Abnormal number of erythroid precursors (HP:0012131)	2.80181706
24	Exertional dyspnea (HP:0002875)	2.78783359
25	Respiratory failure (HP:0002878)	2.76153543
26	Nephronophthisis (HP:0000090)	2.75472823
27	Lactic acidosis (HP:0003128)	2.75376215
28	Methylmalonic acidemia (HP:0002912)	2.72426568
29	Increased intramyocellular lipid droplets (HP:0012240)	2.71438970
30	Congenital primary aphakia (HP:0007707)	2.65933661
31	Gait imbalance (HP:0002141)	2.65905738
32	Congenital, generalized hypertrichosis (HP:0004540)	2.63333831
33	Abnormality of cells of the erythroid lineage (HP:0012130)	2.61810948
34	Increased serum lactate (HP:0002151)	2.59550382
35	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.55676701
36	Abnormality of renal resorption (HP:0011038)	2.55625175
37	Methylmalonic aciduria (HP:0012120)	2.52163653
38	Hyperglycinemia (HP:0002154)	2.50615145
39	Nephrogenic diabetes insipidus (HP:0009806)	2.49930644
40	Colon cancer (HP:0003003)	2.49434750
41	Macrocytic anemia (HP:0001972)	2.39710299
42	Glycosuria (HP:0003076)	2.35771598
43	Abnormality of urine glucose concentration (HP:0011016)	2.35771598
44	Reticulocytopenia (HP:0001896)	2.34664434
45	Hypothermia (HP:0002045)	2.32857145
46	Leukodystrophy (HP:0002415)	2.29288727
47	Exercise intolerance (HP:0003546)	2.28620761
48	Lethargy (HP:0001254)	2.27017819
49	Abolished electroretinogram (ERG) (HP:0000550)	2.23683223
50	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.23600203
51	Myokymia (HP:0002411)	2.21927716
52	Generalized aminoaciduria (HP:0002909)	2.21714661
53	Increased muscle lipid content (HP:0009058)	2.21712365
54	Sclerocornea (HP:0000647)	2.20864874
55	Congenital stationary night blindness (HP:0007642)	2.19667263
56	Abnormality of the renal medulla (HP:0100957)	2.19650534
57	Abnormality of the labia minora (HP:0012880)	2.17757215
58	Type I transferrin isoform profile (HP:0003642)	2.16162025
59	Genital tract atresia (HP:0001827)	2.14051852
60	Vaginal atresia (HP:0000148)	2.07996714
61	Constricted visual fields (HP:0001133)	2.04131189
62	X-linked dominant inheritance (HP:0001423)	2.01746510
63	Abnormality of the anterior horn cell (HP:0006802)	1.99253207
64	Degeneration of anterior horn cells (HP:0002398)	1.99253207
65	Respiratory difficulties (HP:0002880)	1.97606736
66	Male pseudohermaphroditism (HP:0000037)	1.94413949
67	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.90931402
68	Abnormal protein N-linked glycosylation (HP:0012347)	1.90931402
69	Abnormal protein glycosylation (HP:0012346)	1.90931402
70	Abnormal glycosylation (HP:0012345)	1.90931402
71	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.90874518
72	Aplastic anemia (HP:0001915)	1.88536716
73	Cystic liver disease (HP:0006706)	1.88091803
74	Anencephaly (HP:0002323)	1.86711636
75	Renal cortical cysts (HP:0000803)	1.83793701
76	CNS demyelination (HP:0007305)	1.83462602
77	Polyphagia (HP:0002591)	1.82373332
78	Short tibia (HP:0005736)	1.81374818
79	Hyperphosphaturia (HP:0003109)	1.81215071
80	Septo-optic dysplasia (HP:0100842)	1.80630556
81	Optic nerve hypoplasia (HP:0000609)	1.80162072
82	Type II lissencephaly (HP:0007260)	1.79181143
83	Retinal dysplasia (HP:0007973)	1.78941250
84	Abnormal rod and cone electroretinograms (HP:0008323)	1.78731990
85	Postaxial hand polydactyly (HP:0001162)	1.76616615
86	Abnormality of the renal cortex (HP:0011035)	1.76359872
87	Poor suck (HP:0002033)	1.74700120
88	Aplasia/hypoplasia of the uterus (HP:0008684)	1.73411848
89	Intestinal atresia (HP:0011100)	1.73094870
90	Attenuation of retinal blood vessels (HP:0007843)	1.70870522
91	Dicarboxylic aciduria (HP:0003215)	1.70341241
92	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.70341241
93	Postaxial foot polydactyly (HP:0001830)	1.68718263
94	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.68692127
95	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.67479020
96	Abnormality of macular pigmentation (HP:0008002)	1.67089241
97	Hypoglycemic coma (HP:0001325)	1.66048956
98	Emotional lability (HP:0000712)	1.65171165
99	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.65063309
100	Abnormal biliary tract physiology (HP:0012439)	1.64752041

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.78829766
2	BMPR1B	3.25577111
3	MAP4K2	2.76651087
4	STK16	2.72758355
5	TRIM28	2.41079840
6	ZAK	2.39478069
7	WNK3	2.34188232
8	FRK	2.33959639
9	BCKDK	2.32121153
10	VRK1	2.16735077
11	CASK	2.00988390
12	NUAK1	1.84525878
13	TAF1	1.79907327
14	MAP3K12	1.79420666
15	PINK1	1.76647491
16	MST4	1.75989562
17	DYRK2	1.74520072
18	ADRBK2	1.72611383
19	BUB1	1.68910480
20	GRK1	1.68682604
21	CSNK1G3	1.66004395
22	TNIK	1.65694363
23	MARK1	1.63924685
24	CSNK1G1	1.56132267
25	MAP3K9	1.53213971
26	MAP2K7	1.49215050
27	CSNK1G2	1.49035849
28	INSRR	1.37947671
29	TLK1	1.36231510
30	TGFBR1	1.33117754
31	MAP3K4	1.31391082
32	CDK8	1.30878848
33	CSNK1A1L	1.28748370
34	BCR	1.27577333
35	CDK19	1.27431204
36	DYRK3	1.21453001
37	LIMK1	1.20131445
38	PLK3	1.17208769
39	SRPK1	1.15298929
40	PLK2	1.08642722
41	NME1	1.07057267
42	ERBB3	1.01505376
43	EIF2AK3	0.93664921
44	MAPK13	0.91830689
45	NME2	0.88157061
46	PRKCG	0.86798956
47	MKNK1	0.84213749
48	PRKCE	0.78145148
49	OXSR1	0.77596550
50	EPHA4	0.76918252
51	MKNK2	0.76568864
52	RPS6KA5	0.74117479
53	CDC7	0.71818656
54	MYLK	0.71533732
55	CDK3	0.67848027
56	RPS6KA4	0.66459459
57	GRK7	0.65868057
58	MINK1	0.65141056
59	PAK3	0.65117626
60	PLK4	0.63937423
61	FGFR2	0.63814060
62	PLK1	0.61873706
63	GRK5	0.61627386
64	ACVR1B	0.61596627
65	PDK2	0.61595471
66	EIF2AK1	0.60502751
67	ADRBK1	0.60192089
68	DAPK3	0.58917890
69	WNK4	0.58271943
70	CSNK1A1	0.57481148
71	PIM2	0.56868091
72	PHKG2	0.55244612
73	PHKG1	0.55244612
74	PBK	0.52093538
75	KIT	0.52058965
76	EPHB2	0.51306763
77	NEK1	0.49682086
78	DAPK1	0.49634838
79	TIE1	0.49384658
80	CSNK2A2	0.49163672
81	PASK	0.48661705
82	MAPKAPK5	0.48200379
83	PNCK	0.47528373
84	CSNK2A1	0.46477043
85	CCNB1	0.46273684
86	AURKB	0.44821982
87	KDR	0.43426649
88	CAMK2A	0.43344991
89	PRKACA	0.42221683
90	NTRK2	0.41496774
91	STK38L	0.40877242
92	TAOK3	0.38148988
93	CAMK2D	0.37620541
94	AURKA	0.37601719
95	PRKG1	0.34494231
96	TEC	0.34370799
97	FLT3	0.34096240
98	MUSK	0.33699707
99	CHEK2	0.33623305
100	STK39	0.33276347

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	5.02186714
2	Parkinsons disease_Homo sapiens_hsa05012	4.21848317
3	Ribosome_Homo sapiens_hsa03010	3.83432404
4	Protein export_Homo sapiens_hsa03060	3.51644402
5	Proteasome_Homo sapiens_hsa03050	3.36610311
6	Huntingtons disease_Homo sapiens_hsa05016	2.87663027
7	Alzheimers disease_Homo sapiens_hsa05010	2.81335250
8	RNA polymerase_Homo sapiens_hsa03020	2.58604464
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.33675814
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.24981318
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.05460366
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.97624752
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.93650972
14	Homologous recombination_Homo sapiens_hsa03440	1.88841901
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.56043850
16	Mismatch repair_Homo sapiens_hsa03430	1.53995124
17	Phototransduction_Homo sapiens_hsa04744	1.51827967
18	Collecting duct acid secretion_Homo sapiens_hsa04966	1.44086325
19	Butanoate metabolism_Homo sapiens_hsa00650	1.43936070
20	Basal transcription factors_Homo sapiens_hsa03022	1.40950379
21	Fatty acid elongation_Homo sapiens_hsa00062	1.38297267
22	Propanoate metabolism_Homo sapiens_hsa00640	1.37762229
23	RNA degradation_Homo sapiens_hsa03018	1.35148803
24	Pyrimidine metabolism_Homo sapiens_hsa00240	1.34581180
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.27811852
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.22727785
27	Folate biosynthesis_Homo sapiens_hsa00790	1.17912475
28	Purine metabolism_Homo sapiens_hsa00230	1.14379803
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.14108534
30	Base excision repair_Homo sapiens_hsa03410	1.10333201
31	Peroxisome_Homo sapiens_hsa04146	1.10274099
32	Spliceosome_Homo sapiens_hsa03040	1.08831156
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.05890398
34	Glutathione metabolism_Homo sapiens_hsa00480	1.04729138
35	Nitrogen metabolism_Homo sapiens_hsa00910	1.00984628
36	Nucleotide excision repair_Homo sapiens_hsa03420	0.99213252
37	DNA replication_Homo sapiens_hsa03030	0.98559729
38	Tryptophan metabolism_Homo sapiens_hsa00380	0.97225587
39	Asthma_Homo sapiens_hsa05310	0.97151048
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.94859427
41	Sulfur metabolism_Homo sapiens_hsa00920	0.94514443
42	Nicotine addiction_Homo sapiens_hsa05033	0.92350039
43	Metabolic pathways_Homo sapiens_hsa01100	0.87698805
44	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.86085607
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.82944791
46	Non-homologous end-joining_Homo sapiens_hsa03450	0.80282526
47	Regulation of autophagy_Homo sapiens_hsa04140	0.78369884
48	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.75131230
49	One carbon pool by folate_Homo sapiens_hsa00670	0.74766042
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.74354002
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.73790203
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.73704058
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.72828993
54	RNA transport_Homo sapiens_hsa03013	0.71511906
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71382066
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71159077
57	Linoleic acid metabolism_Homo sapiens_hsa00591	0.70951827
58	Selenocompound metabolism_Homo sapiens_hsa00450	0.70159451
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.69641287
60	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.65381271
61	Pyruvate metabolism_Homo sapiens_hsa00620	0.64483145
62	Type I diabetes mellitus_Homo sapiens_hsa04940	0.62923463
63	Rheumatoid arthritis_Homo sapiens_hsa05323	0.62557796
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.62071186
65	Caffeine metabolism_Homo sapiens_hsa00232	0.61407029
66	Olfactory transduction_Homo sapiens_hsa04740	0.60525535
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59814372
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58506580
69	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.58320168
70	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.54542697
71	Ether lipid metabolism_Homo sapiens_hsa00565	0.54479585
72	GABAergic synapse_Homo sapiens_hsa04727	0.52694983
73	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.52445602
74	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.51565698
75	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.50392164
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.49022567
77	Taste transduction_Homo sapiens_hsa04742	0.46609004
78	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.46034459
79	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.44649523
80	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.42789522
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42350234
82	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.41977211
83	Retinol metabolism_Homo sapiens_hsa00830	0.38849447
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38083277
85	Morphine addiction_Homo sapiens_hsa05032	0.36991487
86	Serotonergic synapse_Homo sapiens_hsa04726	0.36887846
87	Graft-versus-host disease_Homo sapiens_hsa05332	0.35571710
88	Sulfur relay system_Homo sapiens_hsa04122	0.34063947
89	Vibrio cholerae infection_Homo sapiens_hsa05110	0.34031037
90	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.31616189
91	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.31478852
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.31430320
93	Allograft rejection_Homo sapiens_hsa05330	0.29509037
94	Insulin secretion_Homo sapiens_hsa04911	0.29486826
95	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.29347403
96	Tyrosine metabolism_Homo sapiens_hsa00350	0.29237701
97	Circadian entrainment_Homo sapiens_hsa04713	0.29037014
98	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.27898541
99	Oocyte meiosis_Homo sapiens_hsa04114	0.26738011
100	Fatty acid degradation_Homo sapiens_hsa00071	0.26624610

LINC01420

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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