LINC01420

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.78830618
2ATP synthesis coupled proton transport (GO:0015986)6.14738489
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.14738489
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.96621380
5protein complex biogenesis (GO:0070271)5.42875442
6respiratory electron transport chain (GO:0022904)5.32165079
7electron transport chain (GO:0022900)5.25237849
8mitochondrial respiratory chain complex assembly (GO:0033108)4.96301401
9chaperone-mediated protein transport (GO:0072321)4.95701730
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.91505210
11NADH dehydrogenase complex assembly (GO:0010257)4.91505210
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.91505210
13protein neddylation (GO:0045116)4.85235209
14establishment of protein localization to mitochondrial membrane (GO:0090151)4.81382032
15respiratory chain complex IV assembly (GO:0008535)4.27312008
16cytochrome complex assembly (GO:0017004)4.11792694
17ribosomal small subunit assembly (GO:0000028)3.92885948
18cullin deneddylation (GO:0010388)3.88709195
19proteasome assembly (GO:0043248)3.80758040
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.79140707
21cotranslational protein targeting to membrane (GO:0006613)3.77897184
22viral transcription (GO:0019083)3.76440952
23hydrogen ion transmembrane transport (GO:1902600)3.74413059
24protein targeting to ER (GO:0045047)3.72982247
25translational termination (GO:0006415)3.71312336
26platelet dense granule organization (GO:0060155)3.67753420
27water-soluble vitamin biosynthetic process (GO:0042364)3.67246537
28sequestering of actin monomers (GO:0042989)3.66829257
29nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.64682612
30protein deneddylation (GO:0000338)3.61056728
31establishment of protein localization to endoplasmic reticulum (GO:0072599)3.60695897
32protein localization to endoplasmic reticulum (GO:0070972)3.57855505
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.57830866
34termination of RNA polymerase III transcription (GO:0006386)3.57830866
35ATP biosynthetic process (GO:0006754)3.55681512
36purine nucleoside triphosphate biosynthetic process (GO:0009145)3.52964965
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.51842998
38purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.51105219
39deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.50936339
40regulation of mitochondrial translation (GO:0070129)3.49248193
41proton transport (GO:0015992)3.44067790
42hydrogen transport (GO:0006818)3.37966025
43GTP biosynthetic process (GO:0006183)3.36613625
44pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.32583350
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.28249222
46tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.28249222
47translational elongation (GO:0006414)3.19248523
48DNA deamination (GO:0045006)3.12154025
49translation (GO:0006412)3.04029142
50ribosomal small subunit biogenesis (GO:0042274)3.03586995
51ribonucleoside triphosphate biosynthetic process (GO:0009201)3.03228893
52mannosylation (GO:0097502)3.01549189
53protein localization to cilium (GO:0061512)2.99596125
54epithelial cilium movement (GO:0003351)2.93352341
55protein targeting to mitochondrion (GO:0006626)2.93100417
56negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.92377629
57DNA damage response, detection of DNA damage (GO:0042769)2.92085563
58protein-cofactor linkage (GO:0018065)2.91740542
59intraciliary transport (GO:0042073)2.90621096
60aldehyde catabolic process (GO:0046185)2.89216965
61regulation of cilium movement (GO:0003352)2.88792531
62intracellular protein transmembrane import (GO:0044743)2.87598940
63nucleoside triphosphate biosynthetic process (GO:0009142)2.86422870
64behavioral response to nicotine (GO:0035095)2.84950660
65viral life cycle (GO:0019058)2.83378805
66nonmotile primary cilium assembly (GO:0035058)2.82157921
67establishment of protein localization to mitochondrion (GO:0072655)2.81693266
68regulation of cellular amino acid metabolic process (GO:0006521)2.80449037
69pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.80423840
70protein localization to mitochondrion (GO:0070585)2.79484504
71spliceosomal snRNP assembly (GO:0000387)2.78459547
72oxidative phosphorylation (GO:0006119)2.77309843
73cellular protein complex disassembly (GO:0043624)2.77290982
74translational initiation (GO:0006413)2.74273418
75deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.73794380
76pyrimidine nucleotide catabolic process (GO:0006244)2.72127012
77maturation of SSU-rRNA (GO:0030490)2.72038814
78positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.70456653
79inner mitochondrial membrane organization (GO:0007007)2.68285755
80ribosomal large subunit biogenesis (GO:0042273)2.67426161
81UTP biosynthetic process (GO:0006228)2.65329394
82DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.64638349
83DNA double-strand break processing (GO:0000729)2.64407265
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.62789321
85anterograde synaptic vesicle transport (GO:0048490)2.60729983
86negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60458396
87negative regulation of ligase activity (GO:0051352)2.60458396
88preassembly of GPI anchor in ER membrane (GO:0016254)2.57878789
89peptidyl-histidine modification (GO:0018202)2.57721902
90C-terminal protein lipidation (GO:0006501)2.57316266
91base-excision repair, AP site formation (GO:0006285)2.57121290
92rRNA modification (GO:0000154)2.56697721
93signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.56330394
94signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.56330394
95signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.56330394
96nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.55143553
97spliceosomal complex assembly (GO:0000245)2.55082546
98cellular component biogenesis (GO:0044085)2.54996290
99UTP metabolic process (GO:0046051)2.54366166
100mitochondrial transport (GO:0006839)2.52616870

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.36662525
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.22481134
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.91574153
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.35543429
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.34548441
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.17419213
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.77624726
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.71622497
9ZNF274_21170338_ChIP-Seq_K562_Hela2.70764450
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.60996562
11ELK1_19687146_ChIP-ChIP_HELA_Human2.56269381
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35501900
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29667755
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27727091
15VDR_23849224_ChIP-Seq_CD4+_Human2.27253510
16FUS_26573619_Chip-Seq_HEK293_Human2.17009987
17EWS_26573619_Chip-Seq_HEK293_Human2.05693779
18VDR_22108803_ChIP-Seq_LS180_Human2.04909824
19IGF1R_20145208_ChIP-Seq_DFB_Human2.02766617
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.99028342
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96364026
22SRF_21415370_ChIP-Seq_HL-1_Mouse1.93064528
23MYC_18940864_ChIP-ChIP_HL60_Human1.89947658
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86370337
25FOXP3_21729870_ChIP-Seq_TREG_Human1.83513479
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80938188
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77194163
28TAF15_26573619_Chip-Seq_HEK293_Human1.74089790
29P300_19829295_ChIP-Seq_ESCs_Human1.66047167
30GBX2_23144817_ChIP-Seq_PC3_Human1.64279771
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62208955
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61447031
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.61038519
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59913768
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58221639
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50707798
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.49156837
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47078007
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42767099
40TP53_22573176_ChIP-Seq_HFKS_Human1.40494751
41TTF2_22483619_ChIP-Seq_HELA_Human1.40283548
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38341536
43EZH2_22144423_ChIP-Seq_EOC_Human1.38113868
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36146821
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36135707
46IRF1_19129219_ChIP-ChIP_H3396_Human1.35300085
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33671354
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30775683
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28111196
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.27744333
51GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25876186
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.25586585
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25322137
54DCP1A_22483619_ChIP-Seq_HELA_Human1.23604137
55ELK1_22589737_ChIP-Seq_MCF10A_Human1.22235686
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21705485
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21629845
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20648852
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20566556
60GABP_19822575_ChIP-Seq_HepG2_Human1.19616602
61NANOG_19829295_ChIP-Seq_ESCs_Human1.16817343
62SOX2_19829295_ChIP-Seq_ESCs_Human1.16817343
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16314024
64SOX2_16153702_ChIP-ChIP_HESCs_Human1.14800501
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14714850
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.14714850
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13298139
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13230682
69RNF2_27304074_Chip-Seq_NSC_Mouse1.13005876
70HTT_18923047_ChIP-ChIP_STHdh_Human1.13004687
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12171436
72CBP_20019798_ChIP-Seq_JUKART_Human1.12171436
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10965651
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05378017
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04216070
76BCAT_22108803_ChIP-Seq_LS180_Human1.01224431
77AR_20517297_ChIP-Seq_VCAP_Human1.00891470
78MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00862500
79ER_23166858_ChIP-Seq_MCF-7_Human1.00347413
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00335587
81E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99915145
82NCOR_22424771_ChIP-Seq_293T_Human0.99476602
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97419046
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97322000
85XRN2_22483619_ChIP-Seq_HELA_Human0.97201526
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97019473
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94592999
88NANOG_16153702_ChIP-ChIP_HESCs_Human0.93864779
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93607708
90PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92094396
91KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91295090
92AR_25329375_ChIP-Seq_VCAP_Human0.90678894
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90418065
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89249613
95TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89233820
96CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86927358
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86325646
98GATA3_21878914_ChIP-Seq_MCF-7_Human0.86320775
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84385662
100SMAD4_21799915_ChIP-Seq_A2780_Human0.84251395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006072_abnormal_retinal_apoptosis2.84462633
2MP0006292_abnormal_olfactory_placode2.79294811
3MP0003880_abnormal_central_pattern2.77109979
4MP0002837_dystrophic_cardiac_calcinosis2.54685890
5MP0003787_abnormal_imprinting2.46075021
6MP0001529_abnormal_vocalization2.36446785
7MP0008877_abnormal_DNA_methylation2.28476043
8MP0002102_abnormal_ear_morphology2.27817092
9MP0009379_abnormal_foot_pigmentation2.24089269
10MP0006276_abnormal_autonomic_nervous2.17526713
11MP0003122_maternal_imprinting2.16984614
12MP0001984_abnormal_olfaction2.10611016
13MP0001968_abnormal_touch/_nociception2.07821394
14MP0005084_abnormal_gallbladder_morpholo2.06718186
15MP0003136_yellow_coat_color2.04654439
16MP0005646_abnormal_pituitary_gland2.00939188
17MP0008789_abnormal_olfactory_epithelium1.99830925
18MP0000372_irregular_coat_pigmentation1.97414913
19MP0003121_genomic_imprinting1.96927399
20MP0001905_abnormal_dopamine_level1.89149862
21MP0003011_delayed_dark_adaptation1.84381891
22MP0002938_white_spotting1.83814722
23MP0003186_abnormal_redox_activity1.83669211
24MP0002736_abnormal_nociception_after1.81488886
25MP0008058_abnormal_DNA_repair1.81156005
26MP0005253_abnormal_eye_physiology1.75694417
27MP0005551_abnormal_eye_electrophysiolog1.72153727
28MP0002163_abnormal_gland_morphology1.70986480
29MP0004142_abnormal_muscle_tone1.70449151
30MP0002653_abnormal_ependyma_morphology1.67328148
31MP0003195_calcinosis1.66446363
32MP0005645_abnormal_hypothalamus_physiol1.64526244
33MP0005394_taste/olfaction_phenotype1.58699679
34MP0005499_abnormal_olfactory_system1.58699679
35MP0009046_muscle_twitch1.57335920
36MP0006036_abnormal_mitochondrial_physio1.56961440
37MP0010386_abnormal_urinary_bladder1.54973822
38MP0005379_endocrine/exocrine_gland_phen1.54602033
39MP0003806_abnormal_nucleotide_metabolis1.53650488
40MP0004133_heterotaxia1.52188954
41MP0000631_abnormal_neuroendocrine_gland1.51643160
42MP0008995_early_reproductive_senescence1.45467373
43MP0002638_abnormal_pupillary_reflex1.41495620
44MP0001485_abnormal_pinna_reflex1.40824901
45MP0002272_abnormal_nervous_system1.40783070
46MP0003718_maternal_effect1.37287697
47MP0009745_abnormal_behavioral_response1.32524700
48MP0002735_abnormal_chemical_nociception1.30503672
49MP0002277_abnormal_respiratory_mucosa1.30092800
50MP0005075_abnormal_melanosome_morpholog1.26245057
51MP0009697_abnormal_copulation1.26043425
52MP0002822_catalepsy1.24715743
53MP0000516_abnormal_urinary_system1.24141851
54MP0005367_renal/urinary_system_phenotyp1.24141851
55MP0001188_hyperpigmentation1.21711139
56MP0001293_anophthalmia1.19465788
57MP0002751_abnormal_autonomic_nervous1.18140159
58MP0002734_abnormal_mechanical_nocicepti1.16780637
59MP0001970_abnormal_pain_threshold1.16032798
60MP0008872_abnormal_physiological_respon1.10908252
61MP0002733_abnormal_thermal_nociception1.07507431
62MP0008875_abnormal_xenobiotic_pharmacok1.06443102
63MP0002557_abnormal_social/conspecific_i1.04524333
64MP0002572_abnormal_emotion/affect_behav1.04280979
65MP0003786_premature_aging0.99980975
66MP0004147_increased_porphyrin_level0.99875480
67MP0004885_abnormal_endolymph0.99402136
68MP0002234_abnormal_pharynx_morphology0.97972383
69MP0006035_abnormal_mitochondrial_morpho0.97959324
70MP0002160_abnormal_reproductive_system0.97948929
71MP0002090_abnormal_vision0.97854434
72MP0005195_abnormal_posterior_eye0.96918920
73MP0002876_abnormal_thyroid_physiology0.94389519
74MP0001486_abnormal_startle_reflex0.94250898
75MP0002752_abnormal_somatic_nervous0.94188140
76MP0005410_abnormal_fertilization0.90554496
77MP0001324_abnormal_eye_pigmentation0.89586007
78MP0000026_abnormal_inner_ear0.89214279
79MP0002095_abnormal_skin_pigmentation0.88627079
80MP0000049_abnormal_middle_ear0.88348088
81MP0002928_abnormal_bile_duct0.88052515
82MP0005389_reproductive_system_phenotype0.87309468
83MP0000778_abnormal_nervous_system0.87164566
84MP0002067_abnormal_sensory_capabilities0.86616996
85MP0002184_abnormal_innervation0.86353567
86MP0002064_seizures0.85990295
87MP0010030_abnormal_orbit_morphology0.84431635
88MP0002233_abnormal_nose_morphology0.84022480
89MP0003137_abnormal_impulse_conducting0.82553280
90MP0001756_abnormal_urination0.82476252
91MP0001764_abnormal_homeostasis0.81768269
92MP0003693_abnormal_embryo_hatching0.80034344
93MP0005391_vision/eye_phenotype0.79830683
94MP0001963_abnormal_hearing_physiology0.78143387
95MP0005377_hearing/vestibular/ear_phenot0.76537813
96MP0003878_abnormal_ear_physiology0.76537813
97MP0002210_abnormal_sex_determination0.75048651
98MP0005174_abnormal_tail_pigmentation0.74658701
99MP0002909_abnormal_adrenal_gland0.74039726
100MP0002282_abnormal_trachea_morphology0.73405622

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.42184033
2Mitochondrial inheritance (HP:0001427)4.90124424
3Abnormal mitochondria in muscle tissue (HP:0008316)4.79411812
4Acute encephalopathy (HP:0006846)4.70245153
5Progressive macrocephaly (HP:0004481)4.69855600
6Increased CSF lactate (HP:0002490)4.37894649
7Hepatocellular necrosis (HP:0001404)4.23955960
8Increased hepatocellular lipid droplets (HP:0006565)4.13331071
9Hepatic necrosis (HP:0002605)4.03424792
10Lipid accumulation in hepatocytes (HP:0006561)3.86432989
113-Methylglutaconic aciduria (HP:0003535)3.83958440
12Renal Fanconi syndrome (HP:0001994)3.69097331
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.42253904
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.42253904
15Cerebral edema (HP:0002181)3.41547797
16Pancreatic fibrosis (HP:0100732)3.38684017
17Pancreatic cysts (HP:0001737)3.33140747
18Abnormality of midbrain morphology (HP:0002418)3.31312214
19Molar tooth sign on MRI (HP:0002419)3.31312214
20Medial flaring of the eyebrow (HP:0010747)3.24695105
21True hermaphroditism (HP:0010459)3.21410857
22Optic disc pallor (HP:0000543)3.04353074
23Abnormal number of erythroid precursors (HP:0012131)2.80181706
24Exertional dyspnea (HP:0002875)2.78783359
25Respiratory failure (HP:0002878)2.76153543
26Nephronophthisis (HP:0000090)2.75472823
27Lactic acidosis (HP:0003128)2.75376215
28Methylmalonic acidemia (HP:0002912)2.72426568
29Increased intramyocellular lipid droplets (HP:0012240)2.71438970
30Congenital primary aphakia (HP:0007707)2.65933661
31Gait imbalance (HP:0002141)2.65905738
32Congenital, generalized hypertrichosis (HP:0004540)2.63333831
33Abnormality of cells of the erythroid lineage (HP:0012130)2.61810948
34Increased serum lactate (HP:0002151)2.59550382
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.55676701
36Abnormality of renal resorption (HP:0011038)2.55625175
37Methylmalonic aciduria (HP:0012120)2.52163653
38Hyperglycinemia (HP:0002154)2.50615145
39Nephrogenic diabetes insipidus (HP:0009806)2.49930644
40Colon cancer (HP:0003003)2.49434750
41Macrocytic anemia (HP:0001972)2.39710299
42Glycosuria (HP:0003076)2.35771598
43Abnormality of urine glucose concentration (HP:0011016)2.35771598
44Reticulocytopenia (HP:0001896)2.34664434
45Hypothermia (HP:0002045)2.32857145
46Leukodystrophy (HP:0002415)2.29288727
47Exercise intolerance (HP:0003546)2.28620761
48Lethargy (HP:0001254)2.27017819
49Abolished electroretinogram (ERG) (HP:0000550)2.23683223
50Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.23600203
51Myokymia (HP:0002411)2.21927716
52Generalized aminoaciduria (HP:0002909)2.21714661
53Increased muscle lipid content (HP:0009058)2.21712365
54Sclerocornea (HP:0000647)2.20864874
55Congenital stationary night blindness (HP:0007642)2.19667263
56Abnormality of the renal medulla (HP:0100957)2.19650534
57Abnormality of the labia minora (HP:0012880)2.17757215
58Type I transferrin isoform profile (HP:0003642)2.16162025
59Genital tract atresia (HP:0001827)2.14051852
60Vaginal atresia (HP:0000148)2.07996714
61Constricted visual fields (HP:0001133)2.04131189
62X-linked dominant inheritance (HP:0001423)2.01746510
63Abnormality of the anterior horn cell (HP:0006802)1.99253207
64Degeneration of anterior horn cells (HP:0002398)1.99253207
65Respiratory difficulties (HP:0002880)1.97606736
66Male pseudohermaphroditism (HP:0000037)1.94413949
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90931402
68Abnormal protein N-linked glycosylation (HP:0012347)1.90931402
69Abnormal protein glycosylation (HP:0012346)1.90931402
70Abnormal glycosylation (HP:0012345)1.90931402
71Aplasia/Hypoplasia of the tongue (HP:0010295)1.90874518
72Aplastic anemia (HP:0001915)1.88536716
73Cystic liver disease (HP:0006706)1.88091803
74Anencephaly (HP:0002323)1.86711636
75Renal cortical cysts (HP:0000803)1.83793701
76CNS demyelination (HP:0007305)1.83462602
77Polyphagia (HP:0002591)1.82373332
78Short tibia (HP:0005736)1.81374818
79Hyperphosphaturia (HP:0003109)1.81215071
80Septo-optic dysplasia (HP:0100842)1.80630556
81Optic nerve hypoplasia (HP:0000609)1.80162072
82Type II lissencephaly (HP:0007260)1.79181143
83Retinal dysplasia (HP:0007973)1.78941250
84Abnormal rod and cone electroretinograms (HP:0008323)1.78731990
85Postaxial hand polydactyly (HP:0001162)1.76616615
86Abnormality of the renal cortex (HP:0011035)1.76359872
87Poor suck (HP:0002033)1.74700120
88Aplasia/hypoplasia of the uterus (HP:0008684)1.73411848
89Intestinal atresia (HP:0011100)1.73094870
90Attenuation of retinal blood vessels (HP:0007843)1.70870522
91Dicarboxylic aciduria (HP:0003215)1.70341241
92Abnormality of dicarboxylic acid metabolism (HP:0010995)1.70341241
93Postaxial foot polydactyly (HP:0001830)1.68718263
94Abnormality of aspartate family amino acid metabolism (HP:0010899)1.68692127
95Aplasia/Hypoplasia of the tibia (HP:0005772)1.67479020
96Abnormality of macular pigmentation (HP:0008002)1.67089241
97Hypoglycemic coma (HP:0001325)1.66048956
98Emotional lability (HP:0000712)1.65171165
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65063309
100Abnormal biliary tract physiology (HP:0012439)1.64752041

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.78829766
2BMPR1B3.25577111
3MAP4K22.76651087
4STK162.72758355
5TRIM282.41079840
6ZAK2.39478069
7WNK32.34188232
8FRK2.33959639
9BCKDK2.32121153
10VRK12.16735077
11CASK2.00988390
12NUAK11.84525878
13TAF11.79907327
14MAP3K121.79420666
15PINK11.76647491
16MST41.75989562
17DYRK21.74520072
18ADRBK21.72611383
19BUB11.68910480
20GRK11.68682604
21CSNK1G31.66004395
22TNIK1.65694363
23MARK11.63924685
24CSNK1G11.56132267
25MAP3K91.53213971
26MAP2K71.49215050
27CSNK1G21.49035849
28INSRR1.37947671
29TLK11.36231510
30TGFBR11.33117754
31MAP3K41.31391082
32CDK81.30878848
33CSNK1A1L1.28748370
34BCR1.27577333
35CDK191.27431204
36DYRK31.21453001
37LIMK11.20131445
38PLK31.17208769
39SRPK11.15298929
40PLK21.08642722
41NME11.07057267
42ERBB31.01505376
43EIF2AK30.93664921
44MAPK130.91830689
45NME20.88157061
46PRKCG0.86798956
47MKNK10.84213749
48PRKCE0.78145148
49OXSR10.77596550
50EPHA40.76918252
51MKNK20.76568864
52RPS6KA50.74117479
53CDC70.71818656
54MYLK0.71533732
55CDK30.67848027
56RPS6KA40.66459459
57GRK70.65868057
58MINK10.65141056
59PAK30.65117626
60PLK40.63937423
61FGFR20.63814060
62PLK10.61873706
63GRK50.61627386
64ACVR1B0.61596627
65PDK20.61595471
66EIF2AK10.60502751
67ADRBK10.60192089
68DAPK30.58917890
69WNK40.58271943
70CSNK1A10.57481148
71PIM20.56868091
72PHKG20.55244612
73PHKG10.55244612
74PBK0.52093538
75KIT0.52058965
76EPHB20.51306763
77NEK10.49682086
78DAPK10.49634838
79TIE10.49384658
80CSNK2A20.49163672
81PASK0.48661705
82MAPKAPK50.48200379
83PNCK0.47528373
84CSNK2A10.46477043
85CCNB10.46273684
86AURKB0.44821982
87KDR0.43426649
88CAMK2A0.43344991
89PRKACA0.42221683
90NTRK20.41496774
91STK38L0.40877242
92TAOK30.38148988
93CAMK2D0.37620541
94AURKA0.37601719
95PRKG10.34494231
96TEC0.34370799
97FLT30.34096240
98MUSK0.33699707
99CHEK20.33623305
100STK390.33276347

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.02186714
2Parkinsons disease_Homo sapiens_hsa050124.21848317
3Ribosome_Homo sapiens_hsa030103.83432404
4Protein export_Homo sapiens_hsa030603.51644402
5Proteasome_Homo sapiens_hsa030503.36610311
6Huntingtons disease_Homo sapiens_hsa050162.87663027
7Alzheimers disease_Homo sapiens_hsa050102.81335250
8RNA polymerase_Homo sapiens_hsa030202.58604464
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.33675814
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24981318
11Cardiac muscle contraction_Homo sapiens_hsa042602.05460366
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97624752
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93650972
14Homologous recombination_Homo sapiens_hsa034401.88841901
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.56043850
16Mismatch repair_Homo sapiens_hsa034301.53995124
17Phototransduction_Homo sapiens_hsa047441.51827967
18Collecting duct acid secretion_Homo sapiens_hsa049661.44086325
19Butanoate metabolism_Homo sapiens_hsa006501.43936070
20Basal transcription factors_Homo sapiens_hsa030221.40950379
21Fatty acid elongation_Homo sapiens_hsa000621.38297267
22Propanoate metabolism_Homo sapiens_hsa006401.37762229
23RNA degradation_Homo sapiens_hsa030181.35148803
24Pyrimidine metabolism_Homo sapiens_hsa002401.34581180
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27811852
26Fanconi anemia pathway_Homo sapiens_hsa034601.22727785
27Folate biosynthesis_Homo sapiens_hsa007901.17912475
28Purine metabolism_Homo sapiens_hsa002301.14379803
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14108534
30Base excision repair_Homo sapiens_hsa034101.10333201
31Peroxisome_Homo sapiens_hsa041461.10274099
32Spliceosome_Homo sapiens_hsa030401.08831156
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05890398
34Glutathione metabolism_Homo sapiens_hsa004801.04729138
35Nitrogen metabolism_Homo sapiens_hsa009101.00984628
36Nucleotide excision repair_Homo sapiens_hsa034200.99213252
37DNA replication_Homo sapiens_hsa030300.98559729
38Tryptophan metabolism_Homo sapiens_hsa003800.97225587
39Asthma_Homo sapiens_hsa053100.97151048
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94859427
41Sulfur metabolism_Homo sapiens_hsa009200.94514443
42Nicotine addiction_Homo sapiens_hsa050330.92350039
43Metabolic pathways_Homo sapiens_hsa011000.87698805
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86085607
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82944791
46Non-homologous end-joining_Homo sapiens_hsa034500.80282526
47Regulation of autophagy_Homo sapiens_hsa041400.78369884
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75131230
49One carbon pool by folate_Homo sapiens_hsa006700.74766042
50Chemical carcinogenesis_Homo sapiens_hsa052040.74354002
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73790203
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.73704058
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72828993
54RNA transport_Homo sapiens_hsa030130.71511906
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71382066
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71159077
57Linoleic acid metabolism_Homo sapiens_hsa005910.70951827
58Selenocompound metabolism_Homo sapiens_hsa004500.70159451
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69641287
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65381271
61Pyruvate metabolism_Homo sapiens_hsa006200.64483145
62Type I diabetes mellitus_Homo sapiens_hsa049400.62923463
63Rheumatoid arthritis_Homo sapiens_hsa053230.62557796
64Steroid biosynthesis_Homo sapiens_hsa001000.62071186
65Caffeine metabolism_Homo sapiens_hsa002320.61407029
66Olfactory transduction_Homo sapiens_hsa047400.60525535
67beta-Alanine metabolism_Homo sapiens_hsa004100.59814372
68Arachidonic acid metabolism_Homo sapiens_hsa005900.58506580
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58320168
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54542697
71Ether lipid metabolism_Homo sapiens_hsa005650.54479585
72GABAergic synapse_Homo sapiens_hsa047270.52694983
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.52445602
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.51565698
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50392164
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49022567
77Taste transduction_Homo sapiens_hsa047420.46609004
78Synaptic vesicle cycle_Homo sapiens_hsa047210.46034459
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44649523
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42789522
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.42350234
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41977211
83Retinol metabolism_Homo sapiens_hsa008300.38849447
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38083277
85Morphine addiction_Homo sapiens_hsa050320.36991487
86Serotonergic synapse_Homo sapiens_hsa047260.36887846
87Graft-versus-host disease_Homo sapiens_hsa053320.35571710
88Sulfur relay system_Homo sapiens_hsa041220.34063947
89Vibrio cholerae infection_Homo sapiens_hsa051100.34031037
90Autoimmune thyroid disease_Homo sapiens_hsa053200.31616189
91N-Glycan biosynthesis_Homo sapiens_hsa005100.31478852
92Hedgehog signaling pathway_Homo sapiens_hsa043400.31430320
93Allograft rejection_Homo sapiens_hsa053300.29509037
94Insulin secretion_Homo sapiens_hsa049110.29486826
95Systemic lupus erythematosus_Homo sapiens_hsa053220.29347403
96Tyrosine metabolism_Homo sapiens_hsa003500.29237701
97Circadian entrainment_Homo sapiens_hsa047130.29037014
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27898541
99Oocyte meiosis_Homo sapiens_hsa041140.26738011
100Fatty acid degradation_Homo sapiens_hsa000710.26624610

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