LINGO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.73502736
2synaptic vesicle maturation (GO:0016188)6.57474569
3locomotory exploration behavior (GO:0035641)6.23153946
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.12624975
5glutamate secretion (GO:0014047)5.92993527
6vocalization behavior (GO:0071625)5.90613906
7synaptic vesicle exocytosis (GO:0016079)5.80962386
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.79585126
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.77683037
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.65275427
11regulation of synaptic vesicle exocytosis (GO:2000300)5.41637620
12protein localization to synapse (GO:0035418)5.32574586
13regulation of glutamate receptor signaling pathway (GO:1900449)5.31257388
14exploration behavior (GO:0035640)4.85400159
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.83612644
16regulation of synaptic vesicle transport (GO:1902803)4.82613762
17regulation of neuronal synaptic plasticity (GO:0048168)4.81987521
18neuron cell-cell adhesion (GO:0007158)4.79788104
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.74077867
20layer formation in cerebral cortex (GO:0021819)4.63461934
21dendritic spine morphogenesis (GO:0060997)4.62576552
22synaptic transmission, glutamatergic (GO:0035249)4.45911599
23neurotransmitter secretion (GO:0007269)4.43569232
24neuronal action potential propagation (GO:0019227)4.42679936
25neuronal ion channel clustering (GO:0045161)4.38584760
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.31453265
27neurotransmitter-gated ion channel clustering (GO:0072578)4.30611881
28glutamate receptor signaling pathway (GO:0007215)4.29858875
29proline transport (GO:0015824)4.28049630
30regulation of synapse structural plasticity (GO:0051823)4.23778144
31presynaptic membrane organization (GO:0097090)4.15426278
32positive regulation of membrane potential (GO:0045838)4.12529526
33positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.10835738
34regulation of excitatory postsynaptic membrane potential (GO:0060079)4.05049224
35long-term memory (GO:0007616)3.99689319
36neuron-neuron synaptic transmission (GO:0007270)3.97893545
37positive regulation of synapse maturation (GO:0090129)3.91650538
38establishment of mitochondrion localization (GO:0051654)3.90880544
39regulation of synaptic plasticity (GO:0048167)3.87747326
40regulation of postsynaptic membrane potential (GO:0060078)3.84668495
41regulation of dendritic spine morphogenesis (GO:0061001)3.82144024
42central nervous system myelination (GO:0022010)3.78533075
43axon ensheathment in central nervous system (GO:0032291)3.78533075
44postsynaptic membrane organization (GO:0001941)3.76264558
45regulation of neurotransmitter secretion (GO:0046928)3.73419035
46cerebellar granule cell differentiation (GO:0021707)3.72974472
47cellular potassium ion homeostasis (GO:0030007)3.72151419
48neuron recognition (GO:0008038)3.68203169
49gamma-aminobutyric acid transport (GO:0015812)3.65797169
50activation of protein kinase A activity (GO:0034199)3.64596417
51dendritic spine organization (GO:0097061)3.63018169
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.62933653
53positive regulation of neurotransmitter secretion (GO:0001956)3.61445170
54pyrimidine nucleobase catabolic process (GO:0006208)3.59761579
55synaptic vesicle endocytosis (GO:0048488)3.59285765
56mitochondrion transport along microtubule (GO:0047497)3.57907024
57establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.57907024
58adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.56921750
59neurotransmitter transport (GO:0006836)3.54554555
60G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.49834120
61dendrite morphogenesis (GO:0048813)3.47047214
62axonal fasciculation (GO:0007413)3.46820138
63long-term synaptic potentiation (GO:0060291)3.44856805
64regulation of vesicle fusion (GO:0031338)3.43169521
65neuromuscular process controlling balance (GO:0050885)3.42672536
66sodium ion export (GO:0071436)3.41354138
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.40635844
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.38200594
69potassium ion homeostasis (GO:0055075)3.38122033
70regulation of neurotransmitter transport (GO:0051588)3.36562300
71innervation (GO:0060384)3.35211961
72regulation of voltage-gated calcium channel activity (GO:1901385)3.34701522
73positive regulation of neurotransmitter transport (GO:0051590)3.33857035
74regulation of dendritic spine development (GO:0060998)3.32660500
75regulation of synaptic transmission, glutamatergic (GO:0051966)3.31233654
76positive regulation of dendritic spine development (GO:0060999)3.30701769
77transmission of nerve impulse (GO:0019226)3.30222972
78auditory behavior (GO:0031223)3.29515457
79neuromuscular synaptic transmission (GO:0007274)3.27977434
80negative regulation of synaptic transmission, GABAergic (GO:0032229)3.26578021
81gamma-aminobutyric acid signaling pathway (GO:0007214)3.26382079
82regulation of neurotransmitter levels (GO:0001505)3.26371417
83cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.26178134
84chemosensory behavior (GO:0007635)3.23213431
85amino acid import (GO:0043090)3.22019025
86membrane depolarization (GO:0051899)3.22000006
87cell communication by electrical coupling (GO:0010644)3.21094506
88potassium ion import (GO:0010107)3.21055030
89cerebellar Purkinje cell differentiation (GO:0021702)3.19686615
90response to auditory stimulus (GO:0010996)3.19558740
91presynaptic membrane assembly (GO:0097105)3.18677941
92G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.18173072
93positive regulation of synaptic transmission, GABAergic (GO:0032230)3.17863762
94positive regulation of dendritic spine morphogenesis (GO:0061003)3.17469934
95learning (GO:0007612)3.16727903
96behavioral defense response (GO:0002209)3.13820558
97behavioral fear response (GO:0001662)3.13820558
98regulation of ARF protein signal transduction (GO:0032012)3.13613817
99regulation of synaptic transmission (GO:0050804)3.12944332
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09209481
101cell migration in hindbrain (GO:0021535)3.08999048
102glycine transport (GO:0015816)3.08589793
103regulation of synapse maturation (GO:0090128)3.06723026
104social behavior (GO:0035176)3.06255339
105intraspecies interaction between organisms (GO:0051703)3.06255339
106behavioral response to nicotine (GO:0035095)3.05839611
107membrane depolarization during action potential (GO:0086010)3.04390670
108central nervous system projection neuron axonogenesis (GO:0021952)3.03730701
109positive regulation of synaptic transmission (GO:0050806)3.03673587
110synaptic transmission (GO:0007268)3.01553644
111L-amino acid import (GO:0043092)3.00183933
112positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.99496607
113membrane hyperpolarization (GO:0060081)2.99218820
114synapse assembly (GO:0007416)2.97796339
115fear response (GO:0042596)2.97559688
116mechanosensory behavior (GO:0007638)2.97379897
117nucleobase catabolic process (GO:0046113)2.97252737
118dopamine receptor signaling pathway (GO:0007212)2.95261712
119regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.93467582
120neuromuscular process (GO:0050905)2.93296463
121cell differentiation in hindbrain (GO:0021533)2.92786176
122adult walking behavior (GO:0007628)2.91633378
123behavioral response to cocaine (GO:0048148)2.91384124
124axon extension (GO:0048675)2.91054733
125neurofilament cytoskeleton organization (GO:0060052)2.90883230
126cochlea development (GO:0090102)2.90279366
127cerebellar Purkinje cell layer development (GO:0021680)2.89016766

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.46397903
2GBX2_23144817_ChIP-Seq_PC3_Human3.41671583
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21407071
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.20930702
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07816701
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.94340148
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.85917409
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.85917409
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.80827590
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.80138724
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.68247226
12DROSHA_22980978_ChIP-Seq_HELA_Human2.66420413
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.64915550
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.63180812
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.62255771
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58046082
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57639447
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50111492
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.38066300
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37968456
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.35818640
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.30606547
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.26193228
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11739011
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09422443
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99724422
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98618333
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.95848492
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94984321
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89225103
31AR_21572438_ChIP-Seq_LNCaP_Human1.86567316
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72024821
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64544959
34* CTCF_27219007_Chip-Seq_Bcells_Human1.61997873
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.60955454
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59723234
37OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.57251991
38GATA1_26923725_Chip-Seq_HPCs_Mouse1.55758604
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53357413
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52816404
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.51841415
42TP53_20018659_ChIP-ChIP_R1E_Mouse1.45444202
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.40875438
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40147484
45TAF15_26573619_Chip-Seq_HEK293_Human1.40010346
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39245835
47RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35406820
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34629898
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32797209
50ZNF274_21170338_ChIP-Seq_K562_Hela1.27900381
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.27818765
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27760338
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.27577902
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25399480
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24893049
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23703366
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.23404471
58P300_19829295_ChIP-Seq_ESCs_Human1.22177953
59AR_19668381_ChIP-Seq_PC3_Human1.19664483
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.19561069
61KDM2B_26808549_Chip-Seq_K562_Human1.19404490
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.19341996
63* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17554401
64* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15791475
65* AR_25329375_ChIP-Seq_VCAP_Human1.15680596
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14414651
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12845382
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11376392
69* STAT3_23295773_ChIP-Seq_U87_Human1.11231572
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10948799
71LXR_22292898_ChIP-Seq_THP-1_Human1.08830743
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08263539
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07924502
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07696357
75* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07110521
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05282455
77* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04943872
78RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04622627
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03622793
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.03563414
81* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03560765
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02953603
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02699094
84TCF4_23295773_ChIP-Seq_U87_Human1.00886089
85PIAS1_25552417_ChIP-Seq_VCAP_Human0.99821033
86AHR_22903824_ChIP-Seq_MCF-7_Human0.99213492
87* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99102444
88CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98052721
89* RNF2_27304074_Chip-Seq_NSC_Mouse0.98020739
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97597849
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.96479536
92OCT4_19829295_ChIP-Seq_ESCs_Human0.96398246
93SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95976236
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95397589
95* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95101350
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95047412
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95020547
98STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94237328
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93591842
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.93571220
101SMAD3_21741376_ChIP-Seq_HESCs_Human0.93051393
102HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92955008
103SMAD4_21741376_ChIP-Seq_HESCs_Human0.92588632
104IGF1R_20145208_ChIP-Seq_DFB_Human0.92404355
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90600094
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90153671
107KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89945812
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89661566
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88383114
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88233728
111MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87332349
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87086882
113RUNX2_22187159_ChIP-Seq_PCA_Human0.87015699
114RXR_22108803_ChIP-Seq_LS180_Human0.86776677
115ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86717753
116TP53_16413492_ChIP-PET_HCT116_Human0.86639038
117TET1_21490601_ChIP-Seq_MESCs_Mouse0.84918522
118* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84715257
119* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84715257
120JUN_21703547_ChIP-Seq_K562_Human0.84634981
121DPY_21335234_ChIP-Seq_ESCs_Mouse0.83875737
122KLF4_19829295_ChIP-Seq_ESCs_Human0.82266184
123TET1_21451524_ChIP-Seq_MESCs_Mouse0.82135901
124SOX3_22085726_ChIP-Seq_NPCs_Mouse0.81774205
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81099603
126P68_20966046_ChIP-Seq_HELA_Human0.79509978
127SMC4_20622854_ChIP-Seq_HELA_Human0.79383212
128PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78816028
129* CREB1_26743006_Chip-Seq_LNCaP_Human0.76479344
130POU5F1_16518401_ChIP-PET_MESCs_Mouse0.75738708
131SMAD4_21741376_ChIP-Seq_ESCs_Human0.75501792
132RUNX1_26923725_Chip-Seq_HPCs_Mouse0.75303846
133NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.75005843
134DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.73123311
135UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.72832995
136ISL1_27105846_Chip-Seq_CPCs_Mouse0.72791327
137KDM2B_26808549_Chip-Seq_JURKAT_Human0.72693250

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.43306780
2MP0003880_abnormal_central_pattern4.85265299
3MP0003635_abnormal_synaptic_transmissio4.37884732
4MP0004270_analgesia4.06853688
5MP0002063_abnormal_learning/memory/cond3.55385564
6MP0009745_abnormal_behavioral_response3.48910597
7MP0002064_seizures3.16489298
8MP0001968_abnormal_touch/_nociception3.04501884
9MP0003123_paternal_imprinting3.01372965
10MP0005423_abnormal_somatic_nervous2.89441829
11MP0002572_abnormal_emotion/affect_behav2.86136997
12MP0009046_muscle_twitch2.79961036
13MP0002734_abnormal_mechanical_nocicepti2.76387417
14MP0001486_abnormal_startle_reflex2.57294507
15MP0002272_abnormal_nervous_system2.48591175
16MP0002822_catalepsy2.34447051
17MP0002736_abnormal_nociception_after2.32021432
18MP0002735_abnormal_chemical_nociception2.31321201
19MP0004858_abnormal_nervous_system2.23210202
20MP0001501_abnormal_sleep_pattern2.21979838
21MP0009780_abnormal_chondrocyte_physiolo2.21612785
22MP0001440_abnormal_grooming_behavior2.15057693
23MP0002733_abnormal_thermal_nociception2.05656754
24MP0001970_abnormal_pain_threshold2.01227200
25MP0000778_abnormal_nervous_system1.98488811
26MP0004811_abnormal_neuron_physiology1.90949194
27MP0002067_abnormal_sensory_capabilities1.87543835
28MP0008569_lethality_at_weaning1.87121828
29MP0003879_abnormal_hair_cell1.86324748
30MP0002184_abnormal_innervation1.85888514
31MP0003329_amyloid_beta_deposits1.81778171
32MP0002557_abnormal_social/conspecific_i1.80855711
33MP0001984_abnormal_olfaction1.70348353
34MP0003121_genomic_imprinting1.69563314
35MP0005646_abnormal_pituitary_gland1.59966905
36MP0004924_abnormal_behavior1.59704434
37MP0005386_behavior/neurological_phenoty1.59704434
38MP0002909_abnormal_adrenal_gland1.59022138
39MP0000955_abnormal_spinal_cord1.58103812
40MP0002882_abnormal_neuron_morphology1.46813737
41MP0006276_abnormal_autonomic_nervous1.44408304
42MP0004885_abnormal_endolymph1.43077456
43MP0003787_abnormal_imprinting1.40670685
44MP0002066_abnormal_motor_capabilities/c1.40121171
45MP0002653_abnormal_ependyma_morphology1.40118013
46MP0003633_abnormal_nervous_system1.39013091
47MP0008877_abnormal_DNA_methylation1.38131360
48MP0005645_abnormal_hypothalamus_physiol1.34846640
49MP0009379_abnormal_foot_pigmentation1.30811961
50MP0001502_abnormal_circadian_rhythm1.28984226
51MP0001905_abnormal_dopamine_level1.16640407
52MP0003631_nervous_system_phenotype1.16144619
53MP0002152_abnormal_brain_morphology1.15192957
54MP0000569_abnormal_digit_pigmentation1.13701235
55MP0006292_abnormal_olfactory_placode1.12052009
56MP0004142_abnormal_muscle_tone1.05875963
57MP0003075_altered_response_to1.04098921
58MP0008961_abnormal_basal_metabolism1.01451264
59MP0001188_hyperpigmentation0.96507276
60MP0008872_abnormal_physiological_respon0.95268974
61MP0002069_abnormal_eating/drinking_beha0.94981813
62MP0010386_abnormal_urinary_bladder0.94666434
63MP0003938_abnormal_ear_development0.94261205
64MP0000751_myopathy0.93258559
65MP0001177_atelectasis0.92866341
66MP0001529_abnormal_vocalization0.92128582
67MP0003122_maternal_imprinting0.92063875
68MP0004133_heterotaxia0.91457619
69MP0000566_synostosis0.89811314
70MP0008874_decreased_physiological_sensi0.86470585
71MP0001348_abnormal_lacrimal_gland0.85863235
72MP0002229_neurodegeneration0.84723039
73MP0001963_abnormal_hearing_physiology0.82471177
74MP0004510_myositis0.82019769
75MP0005499_abnormal_olfactory_system0.81962937
76MP0005394_taste/olfaction_phenotype0.81962937
77MP0003283_abnormal_digestive_organ0.80980026
78MP0001346_abnormal_lacrimal_gland0.80454360
79MP0000026_abnormal_inner_ear0.79821932
80MP0004742_abnormal_vestibular_system0.79568525
81MP0005551_abnormal_eye_electrophysiolog0.79484983
82MP0004130_abnormal_muscle_cell0.78654943
83MP0003119_abnormal_digestive_system0.78402869
84MP0005535_abnormal_body_temperature0.78187910
85MP0004145_abnormal_muscle_electrophysio0.77846009
86MP0003890_abnormal_embryonic-extraembry0.77716221
87MP0003634_abnormal_glial_cell0.77211849
88MP0003632_abnormal_nervous_system0.75818045
89MP0000604_amyloidosis0.75545918
90MP0004085_abnormal_heartbeat0.75458013
91MP0002752_abnormal_somatic_nervous0.73979271
92MP0000631_abnormal_neuroendocrine_gland0.72865222
93MP0000534_abnormal_ureter_morphology0.71585023
94MP0002638_abnormal_pupillary_reflex0.71402518
95MP0003942_abnormal_urinary_system0.70112868
96MP0002090_abnormal_vision0.69806213
97MP0003690_abnormal_glial_cell0.68922363
98MP0002163_abnormal_gland_morphology0.67890418
99MP0000579_abnormal_nail_morphology0.67526630
100MP0001485_abnormal_pinna_reflex0.65661668
101MP0001664_abnormal_digestion0.65575698
102MP0002081_perinatal_lethality0.65423867
103MP0003861_abnormal_nervous_system0.63063102
104MP0004484_altered_response_of0.62162055
105MP0000049_abnormal_middle_ear0.61623211
106MP0002249_abnormal_larynx_morphology0.60890811
107MP0001986_abnormal_taste_sensitivity0.60459243
108MP0002876_abnormal_thyroid_physiology0.58738287
109MP0005623_abnormal_meninges_morphology0.58334263
110MP0005187_abnormal_penis_morphology0.58255207
111MP0004233_abnormal_muscle_weight0.58060481
112MP0005167_abnormal_blood-brain_barrier0.57175986
113MP0005409_darkened_coat_color0.56749664
114MP0010769_abnormal_survival0.54030454
115MP0003172_abnormal_lysosome_physiology0.53467218
116MP0003137_abnormal_impulse_conducting0.53305380
117MP0001943_abnormal_respiration0.52052548
118* MP0000920_abnormal_myelination0.51203608
119MP0004215_abnormal_myocardial_fiber0.51133320
120MP0002082_postnatal_lethality0.50880997
121MP0010770_preweaning_lethality0.50880997
122MP0010768_mortality/aging0.50669770
123MP0001299_abnormal_eye_distance/0.50396659

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.71234679
2Focal motor seizures (HP:0011153)7.69646842
3Focal seizures (HP:0007359)5.89301582
4Visual hallucinations (HP:0002367)5.53071600
5Epileptic encephalopathy (HP:0200134)5.20064452
6Progressive cerebellar ataxia (HP:0002073)4.62259893
7Febrile seizures (HP:0002373)4.54524447
8Atonic seizures (HP:0010819)4.50862560
9Absence seizures (HP:0002121)4.07538784
10Generalized tonic-clonic seizures (HP:0002069)3.93232014
11Action tremor (HP:0002345)3.93074637
12Dialeptic seizures (HP:0011146)3.72915405
13Supranuclear gaze palsy (HP:0000605)3.69775390
14Broad-based gait (HP:0002136)3.65900798
15Ankle clonus (HP:0011448)3.54938480
16Poor eye contact (HP:0000817)3.50885039
17Impaired vibration sensation in the lower limbs (HP:0002166)3.49946871
18Papilledema (HP:0001085)3.41116621
19Gaze-evoked nystagmus (HP:0000640)3.38434662
20Mutism (HP:0002300)3.36314448
21Amblyopia (HP:0000646)3.30710043
22Urinary bladder sphincter dysfunction (HP:0002839)3.29047106
23Depression (HP:0000716)3.28216595
24Genetic anticipation (HP:0003743)3.21732733
25Hyperventilation (HP:0002883)3.14600840
26Dysmetria (HP:0001310)3.06817543
27Abnormal social behavior (HP:0012433)3.05778644
28Impaired social interactions (HP:0000735)3.05778644
29Dysdiadochokinesis (HP:0002075)3.01422154
30Postural instability (HP:0002172)2.98332391
31Hepatoblastoma (HP:0002884)2.96946085
32Anxiety (HP:0000739)2.94389711
33Abnormal eating behavior (HP:0100738)2.93293183
34Abnormality of the lower motor neuron (HP:0002366)2.86038358
35Truncal ataxia (HP:0002078)2.84760058
36Torticollis (HP:0000473)2.80927107
37Drooling (HP:0002307)2.80149052
38Excessive salivation (HP:0003781)2.80149052
39Impaired smooth pursuit (HP:0007772)2.74171365
40Megalencephaly (HP:0001355)2.68728042
41Focal dystonia (HP:0004373)2.68664571
42Urinary urgency (HP:0000012)2.68607010
43Stereotypic behavior (HP:0000733)2.61541372
44Epileptiform EEG discharges (HP:0011182)2.61166124
45Hemiparesis (HP:0001269)2.57960666
46Cerebral hypomyelination (HP:0006808)2.54562739
47Abnormality of binocular vision (HP:0011514)2.52153535
48Diplopia (HP:0000651)2.52153535
49Obstructive sleep apnea (HP:0002870)2.51210752
50Peripheral hypomyelination (HP:0007182)2.49792536
51Spastic gait (HP:0002064)2.48090786
52Bradykinesia (HP:0002067)2.45774544
53Cerebral inclusion bodies (HP:0100314)2.44289602
54EEG with generalized epileptiform discharges (HP:0011198)2.42619495
55Neurofibrillary tangles (HP:0002185)2.42290686
56Absent speech (HP:0001344)2.38017084
57Ventricular fibrillation (HP:0001663)2.36271183
58Impaired vibratory sensation (HP:0002495)2.35979217
59Abnormality of ocular smooth pursuit (HP:0000617)2.35177641
60Hemiplegia (HP:0002301)2.34506830
61Progressive inability to walk (HP:0002505)2.33774952
62Fetal akinesia sequence (HP:0001989)2.32018080
63Limb dystonia (HP:0002451)2.31075804
64Hypsarrhythmia (HP:0002521)2.30772381
65Craniofacial dystonia (HP:0012179)2.29853580
66Intention tremor (HP:0002080)2.29128769
67Termporal pattern (HP:0011008)2.28443248
68Insidious onset (HP:0003587)2.28443248
69Scanning speech (HP:0002168)2.27848846
70Turricephaly (HP:0000262)2.25472415
71Inability to walk (HP:0002540)2.21752102
72Agitation (HP:0000713)2.15472688
73Abnormality of the corticospinal tract (HP:0002492)2.13757941
74Lower limb muscle weakness (HP:0007340)2.13278465
75Annular pancreas (HP:0001734)2.13082872
76Spastic tetraparesis (HP:0001285)2.12828885
77Pointed chin (HP:0000307)2.12548740
78Generalized myoclonic seizures (HP:0002123)2.10270163
79Polyphagia (HP:0002591)2.09995241
80Aplasia involving bones of the extremities (HP:0009825)2.09930407
81Aplasia involving bones of the upper limbs (HP:0009823)2.09930407
82Aplasia of the phalanges of the hand (HP:0009802)2.09930407
83Abnormality of the labia minora (HP:0012880)2.09881905
84Insomnia (HP:0100785)2.09500865
85Thickened helices (HP:0000391)2.09041123
86Status epilepticus (HP:0002133)2.05683585
87Incomplete penetrance (HP:0003829)2.04673490
88Dysmetric saccades (HP:0000641)2.03048646
89Hyperthyroidism (HP:0000836)2.02084976
90Inappropriate behavior (HP:0000719)2.01557081
91Bundle branch block (HP:0011710)2.01415132
92Morphological abnormality of the pyramidal tract (HP:0002062)1.96111210
93Abnormality of salivation (HP:0100755)1.94278188
94Deep palmar crease (HP:0006191)1.93115817
95Delusions (HP:0000746)1.91678303
96Amyotrophic lateral sclerosis (HP:0007354)1.91388848
97Blue irides (HP:0000635)1.88530460
98Lower limb amyotrophy (HP:0007210)1.88257858
99Gait ataxia (HP:0002066)1.86693032
100Spastic tetraplegia (HP:0002510)1.86593093
101Apathy (HP:0000741)1.85490522
102Bronchomalacia (HP:0002780)1.84025877
103Tetraplegia (HP:0002445)1.83173234
104Poor suck (HP:0002033)1.82344797
105Pheochromocytoma (HP:0002666)1.82048249
106Sleep apnea (HP:0010535)1.81209514
107Lower limb asymmetry (HP:0100559)1.80695316
108Anomalous pulmonary venous return (HP:0010772)1.76591939
109Akinesia (HP:0002304)1.74177362
110Abnormal EKG (HP:0003115)1.73956125
111Partial duplication of thumb phalanx (HP:0009944)1.73846637
112Anosmia (HP:0000458)1.73755345
113Aqueductal stenosis (HP:0002410)1.73197870
114Clonus (HP:0002169)1.72662228
115Protruding tongue (HP:0010808)1.72545334
116Intellectual disability, profound (HP:0002187)1.72133291
117CNS hypomyelination (HP:0003429)1.71563694
118Rigidity (HP:0002063)1.71384561
119Overriding aorta (HP:0002623)1.70013416
120Failure to thrive in infancy (HP:0001531)1.69864289
121Hypoventilation (HP:0002791)1.68839834
122Rapidly progressive (HP:0003678)1.67854227
123Hypoplasia of the corpus callosum (HP:0002079)1.65480266
124Neoplasm of the adrenal cortex (HP:0100641)1.64147243
125Split foot (HP:0001839)1.63133846
126Diminished motivation (HP:0000745)1.61899838

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.54128130
2NTRK34.43981533
3MAP3K93.89449699
4MARK13.49172514
5DAPK23.17441373
6MAP3K42.80623133
7MINK12.74800133
8PAK62.50228400
9MAP2K72.50199944
10PRKD32.29241052
11NTRK22.14120577
12KSR22.01763201
13CAMKK11.98046325
14DAPK11.96470077
15NTRK11.79702157
16MAP3K121.78961823
17PLK21.78064321
18CASK1.75376965
19MAP2K41.72767635
20RIPK41.68232713
21KSR11.67223937
22DYRK21.66481086
23CDK51.62123807
24BRAF1.57849642
25TNIK1.52219093
26GRK51.48784487
27MAPK131.48523597
28SIK21.48096088
29PRPF4B1.42443065
30CDK191.40113904
31PRKCG1.28358349
32STK381.28223008
33LATS21.21213460
34ARAF1.19179280
35TAOK11.17629332
36UHMK11.13332342
37MAP3K21.11853434
38TYRO31.11376080
39CAMK11.05928337
40PHKG21.04905347
41PHKG11.04905347
42FES1.02332405
43MAP3K130.98256251
44CAMK1D0.97435519
45PNCK0.96879604
46CDK180.95691468
47CAMK2A0.95277661
48CDK150.93736110
49STK110.92776180
50FGFR20.88909224
51MARK20.88896484
52CDK140.88731937
53CAMKK20.86406869
54PAK30.82686639
55CDK11A0.82361215
56RAF10.79980193
57SGK2230.79916459
58SGK4940.79916459
59ALK0.79683173
60ICK0.79343176
61PKN10.78115802
62RET0.78091337
63PRKCH0.77833926
64CSNK1G20.77756078
65PTK2B0.76840107
66CAMK2B0.76553616
67DYRK1A0.74618589
68MAP3K110.70491276
69SGK10.68343750
70BMPR20.67653616
71SGK20.66474088
72CCNB10.66104310
73PDK10.64521801
74PINK10.63227373
75ERBB20.61893923
76LMTK20.61079034
77SGK30.58377415
78OXSR10.56664582
79PDPK10.54642611
80DAPK30.54619567
81PRKCZ0.52848490
82CSNK1E0.51486374
83DYRK1B0.51210508
84CAMK40.49767685
85MAP3K10.49361105
86MAP3K70.47417714
87RPS6KA30.45779266
88PRKCE0.45485937
89NEK60.45284460
90BRSK10.44083664
91MAP2K20.43791259
92EPHB20.43241307
93FYN0.42296493
94DMPK0.41949861
95CAMK1G0.41918543
96CDC42BPA0.41700673
97RIPK10.41374440
98WNK40.40412065
99SIK30.40158926
100TNK20.40141672
101MAPK80.37621743
102EEF2K0.37118828
103GSK3B0.37025821
104MAPK100.36752413
105LIMK10.35597320
106PRKACA0.35458221
107MAP2K10.35178110
108CAMK2G0.34977213
109MAPK120.34167717
110CAMK2D0.34123698
111PRKCI0.33757317
112SCYL20.33730469
113RPS6KA20.33250813
114MAP3K60.32598526
115NME10.32039210
116CSNK1D0.31328793
117FER0.30634720
118PRKCA0.30530395
119PRKCB0.29331377
120PRKG10.29272389
121CSNK1A10.29079023
122MAP2K60.28634647
123PRKDC0.28459510
124CSNK1G30.28459020
125WNK10.28161052
126FGR0.27653171
127MAPK90.24564931

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.58883744
2Synaptic vesicle cycle_Homo sapiens_hsa047213.36424303
3Olfactory transduction_Homo sapiens_hsa047402.98022403
4Circadian entrainment_Homo sapiens_hsa047132.80712147
5Long-term potentiation_Homo sapiens_hsa047202.71491679
6Glutamatergic synapse_Homo sapiens_hsa047242.64584760
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.61071030
8GABAergic synapse_Homo sapiens_hsa047272.53603280
9Amphetamine addiction_Homo sapiens_hsa050312.47738015
10Morphine addiction_Homo sapiens_hsa050322.44316558
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29340126
12Salivary secretion_Homo sapiens_hsa049702.23335535
13Insulin secretion_Homo sapiens_hsa049112.13868251
14Dopaminergic synapse_Homo sapiens_hsa047282.13628412
15Cholinergic synapse_Homo sapiens_hsa047252.00526883
16Gastric acid secretion_Homo sapiens_hsa049711.95922783
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94157870
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72148632
19Oxytocin signaling pathway_Homo sapiens_hsa049211.71483534
20Taste transduction_Homo sapiens_hsa047421.63415138
21Long-term depression_Homo sapiens_hsa047301.60123758
22Calcium signaling pathway_Homo sapiens_hsa040201.59434936
23Renin secretion_Homo sapiens_hsa049241.57704905
24Serotonergic synapse_Homo sapiens_hsa047261.55804804
25Cocaine addiction_Homo sapiens_hsa050301.54422979
26GnRH signaling pathway_Homo sapiens_hsa049121.49349888
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47427298
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44825141
29Gap junction_Homo sapiens_hsa045401.34094838
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33626306
31cAMP signaling pathway_Homo sapiens_hsa040241.30554300
32Glioma_Homo sapiens_hsa052141.29377134
33Vitamin B6 metabolism_Homo sapiens_hsa007501.28839656
34Type II diabetes mellitus_Homo sapiens_hsa049301.26329125
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24782104
36Collecting duct acid secretion_Homo sapiens_hsa049661.23662257
37Axon guidance_Homo sapiens_hsa043601.23629702
38Estrogen signaling pathway_Homo sapiens_hsa049151.19711559
39Melanogenesis_Homo sapiens_hsa049161.12255555
40ErbB signaling pathway_Homo sapiens_hsa040121.11269601
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10426520
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06424123
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97580526
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95605362
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.91940256
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90777088
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90777030
48Oocyte meiosis_Homo sapiens_hsa041140.88878727
49Nitrogen metabolism_Homo sapiens_hsa009100.87586759
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85822835
51Cardiac muscle contraction_Homo sapiens_hsa042600.85753693
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.85678562
53Pancreatic secretion_Homo sapiens_hsa049720.83785410
54Alzheimers disease_Homo sapiens_hsa050100.83657986
55Vibrio cholerae infection_Homo sapiens_hsa051100.83462305
56Dorso-ventral axis formation_Homo sapiens_hsa043200.80048526
57Phototransduction_Homo sapiens_hsa047440.78990554
58Thyroid hormone synthesis_Homo sapiens_hsa049180.77622536
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76799233
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.76576595
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75181267
62Parkinsons disease_Homo sapiens_hsa050120.74026064
63Hippo signaling pathway_Homo sapiens_hsa043900.73728474
64Dilated cardiomyopathy_Homo sapiens_hsa054140.73720857
65Oxidative phosphorylation_Homo sapiens_hsa001900.73016994
66Choline metabolism in cancer_Homo sapiens_hsa052310.72540278
67MAPK signaling pathway_Homo sapiens_hsa040100.72283585
68VEGF signaling pathway_Homo sapiens_hsa043700.70941557
69Basal cell carcinoma_Homo sapiens_hsa052170.70822983
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67872561
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65899186
72Hedgehog signaling pathway_Homo sapiens_hsa043400.63891091
73Ras signaling pathway_Homo sapiens_hsa040140.63641995
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61640654
75Rap1 signaling pathway_Homo sapiens_hsa040150.59763590
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.58860129
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57315263
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56887933
79Glucagon signaling pathway_Homo sapiens_hsa049220.56255590
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55689902
81Notch signaling pathway_Homo sapiens_hsa043300.55111370
82Endometrial cancer_Homo sapiens_hsa052130.54440151
83mTOR signaling pathway_Homo sapiens_hsa041500.53228429
84Endocytosis_Homo sapiens_hsa041440.51354571
85Wnt signaling pathway_Homo sapiens_hsa043100.48775504
86Circadian rhythm_Homo sapiens_hsa047100.48273122
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48243924
88Non-small cell lung cancer_Homo sapiens_hsa052230.47667155
89Alcoholism_Homo sapiens_hsa050340.46445090
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45741248
91Type I diabetes mellitus_Homo sapiens_hsa049400.45477264
92Tight junction_Homo sapiens_hsa045300.44942553
93Huntingtons disease_Homo sapiens_hsa050160.44526965
94Bile secretion_Homo sapiens_hsa049760.44305266
95African trypanosomiasis_Homo sapiens_hsa051430.43914933
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43487159
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43364060
98Inositol phosphate metabolism_Homo sapiens_hsa005620.42783659
99Renal cell carcinoma_Homo sapiens_hsa052110.41621224
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41328008
101Prion diseases_Homo sapiens_hsa050200.41323145
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40459113
103Insulin signaling pathway_Homo sapiens_hsa049100.40423357
104Ovarian steroidogenesis_Homo sapiens_hsa049130.38934293
105Chemokine signaling pathway_Homo sapiens_hsa040620.37094264
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36468574
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35375337
108Arginine and proline metabolism_Homo sapiens_hsa003300.33279408
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32531749
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31794344
111Colorectal cancer_Homo sapiens_hsa052100.30487624
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30052188
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29146679
114Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27670328
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26023969
116AMPK signaling pathway_Homo sapiens_hsa041520.25964897
117Arginine biosynthesis_Homo sapiens_hsa002200.25038049
118Prolactin signaling pathway_Homo sapiens_hsa049170.24988949
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24939807
120Fatty acid biosynthesis_Homo sapiens_hsa000610.19607125

Most similar genes based on co-expression Upload to Enrichr

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