

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | neuron cell-cell adhesion (GO:0007158) | 6.21438754 |
| 2 | pyrimidine nucleobase catabolic process (GO:0006208) | 5.44417371 |
| 3 | presynaptic membrane assembly (GO:0097105) | 5.40297449 |
| 4 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 4.90283095 |
| 5 | nucleobase catabolic process (GO:0046113) | 4.85871086 |
| 6 | presynaptic membrane organization (GO:0097090) | 4.82708308 |
| 7 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.70361282 |
| 8 | regulation of feeding behavior (GO:0060259) | 4.68928701 |
| 9 | synaptic vesicle exocytosis (GO:0016079) | 4.68078491 |
| 10 | vocalization behavior (GO:0071625) | 4.64929142 |
| 11 | protein localization to synapse (GO:0035418) | 4.54412733 |
| 12 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.47314379 |
| 13 | glutamate secretion (GO:0014047) | 4.37600555 |
| 14 | neuronal action potential propagation (GO:0019227) | 4.33064953 |
| 15 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.31336071 |
| 16 | neuron recognition (GO:0008038) | 4.26479547 |
| 17 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.14773970 |
| 18 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.11259939 |
| 19 | axonal fasciculation (GO:0007413) | 4.09777634 |
| 20 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.05607085 |
| 21 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.98305906 |
| 22 | transmission of nerve impulse (GO:0019226) | 3.93153526 |
| 23 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.87673836 |
| 24 | postsynaptic membrane organization (GO:0001941) | 3.87330559 |
| 25 | glutamate receptor signaling pathway (GO:0007215) | 3.86635597 |
| 26 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.78450701 |
| 27 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.77271089 |
| 28 | sensory perception of smell (GO:0007608) | 3.72678859 |
| 29 | neuron-neuron synaptic transmission (GO:0007270) | 3.70441328 |
| 30 | cerebellar granule cell differentiation (GO:0021707) | 3.66046627 |
| 31 | positive regulation of mitochondrial fission (GO:0090141) | 3.65437922 |
| 32 | synaptic transmission, glutamatergic (GO:0035249) | 3.64399462 |
| 33 | retinal ganglion cell axon guidance (GO:0031290) | 3.54340098 |
| 34 | glycosphingolipid biosynthetic process (GO:0006688) | 3.53151498 |
| 35 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.52016906 |
| 36 | negative regulation of neurotransmitter transport (GO:0051589) | 3.50017267 |
| 37 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.47481127 |
| 38 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.46160581 |
| 39 | regulation of synaptic vesicle transport (GO:1902803) | 3.43487896 |
| 40 | response to histamine (GO:0034776) | 3.42997181 |
| 41 | dendritic spine morphogenesis (GO:0060997) | 3.42689834 |
| 42 | positive regulation of gastrulation (GO:2000543) | 3.41431550 |
| 43 | regulation of postsynaptic membrane potential (GO:0060078) | 3.36671860 |
| 44 | behavioral response to cocaine (GO:0048148) | 3.36062072 |
| 45 | positive regulation of membrane potential (GO:0045838) | 3.35320813 |
| 46 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.35095493 |
| 47 | neurotransmitter secretion (GO:0007269) | 3.29459819 |
| 48 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.28848272 |
| 49 | synaptic vesicle maturation (GO:0016188) | 3.28730430 |
| 50 | positive regulation of synapse assembly (GO:0051965) | 3.28231516 |
| 51 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.27213469 |
| 52 | regulation of glutamate secretion (GO:0014048) | 3.26576243 |
| 53 | negative regulation of neurotransmitter secretion (GO:0046929) | 3.26303205 |
| 54 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339) | 3.25112696 |
| 55 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.24001973 |
| 56 | exploration behavior (GO:0035640) | 3.23395826 |
| 57 | mating behavior (GO:0007617) | 3.22402633 |
| 58 | regulation of vesicle fusion (GO:0031338) | 3.22299665 |
| 59 | locomotory exploration behavior (GO:0035641) | 3.22201225 |
| 60 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.20792956 |
| 61 | epithelial cilium movement (GO:0003351) | 3.18463395 |
| 62 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.16508007 |
| 63 | dendrite development (GO:0016358) | 3.14961942 |
| 64 | retinal cone cell development (GO:0046549) | 3.14781449 |
| 65 | detection of calcium ion (GO:0005513) | 3.11183356 |
| 66 | membrane hyperpolarization (GO:0060081) | 3.10685194 |
| 67 | long-term synaptic potentiation (GO:0060291) | 3.09900518 |
| 68 | positive regulation of amino acid transport (GO:0051957) | 3.09221538 |
| 69 | regulation of neurotransmitter secretion (GO:0046928) | 3.07781003 |
| 70 | protein localization to cilium (GO:0061512) | 3.02779497 |
| 71 | regulation of synaptic plasticity (GO:0048167) | 3.00220397 |
| 72 | membrane depolarization (GO:0051899) | 2.99662488 |
| 73 | synapse assembly (GO:0007416) | 2.97021788 |
| 74 | regulation of dendritic spine development (GO:0060998) | 2.96132055 |
| 75 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.96112614 |
| 76 | adult walking behavior (GO:0007628) | 2.95551416 |
| 77 | synaptic vesicle endocytosis (GO:0048488) | 2.95355850 |
| 78 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.95311228 |
| 79 | membrane assembly (GO:0071709) | 2.94359558 |
| 80 | dendrite morphogenesis (GO:0048813) | 2.93865613 |
| 81 | negative regulation of peptidyl-threonine phosphorylation (GO:0010801) | 2.92951087 |
| 82 | cell migration in hindbrain (GO:0021535) | 2.92805680 |
| 83 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 2.92163541 |
| 84 | regulation of synapse structural plasticity (GO:0051823) | 2.92113761 |
| 85 | long-chain fatty acid biosynthetic process (GO:0042759) | 2.91720791 |
| 86 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.90803651 |
| 87 | mechanosensory behavior (GO:0007638) | 2.90789767 |
| 88 | intraciliary transport (GO:0042073) | 2.90589920 |
| 89 | positive regulation of synapse maturation (GO:0090129) | 2.90161928 |
| 90 | startle response (GO:0001964) | 2.89479000 |
| 91 | layer formation in cerebral cortex (GO:0021819) | 2.89313813 |
| 92 | nonmotile primary cilium assembly (GO:0035058) | 2.88859292 |
| 93 | neurotransmitter transport (GO:0006836) | 2.88787621 |
| 94 | gamma-aminobutyric acid transport (GO:0015812) | 2.88264372 |
| 95 | axon ensheathment in central nervous system (GO:0032291) | 2.86531990 |
| 96 | central nervous system myelination (GO:0022010) | 2.86531990 |
| 97 | negative regulation of amino acid transport (GO:0051956) | 2.85220029 |
| 98 | regulation of cell communication by electrical coupling (GO:0010649) | 2.84342854 |
| 99 | positive regulation of neurotransmitter secretion (GO:0001956) | 2.83233994 |
| 100 | short-term memory (GO:0007614) | 2.82488627 |
| 101 | neuronal ion channel clustering (GO:0045161) | 2.81983075 |
| 102 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 2.80753223 |
| 103 | synapse organization (GO:0050808) | 2.80245479 |
| 104 | auditory behavior (GO:0031223) | 2.80093705 |
| 105 | regulation of synapse assembly (GO:0051963) | 2.79502913 |
| 106 | membrane depolarization during action potential (GO:0086010) | 2.79486688 |
| 107 | behavioral defense response (GO:0002209) | 2.78624889 |
| 108 | behavioral fear response (GO:0001662) | 2.78624889 |
| 109 | regulation of neurotransmitter transport (GO:0051588) | 2.77521073 |
| 110 | fear response (GO:0042596) | 2.77012393 |
| 111 | positive regulation of neurotransmitter transport (GO:0051590) | 2.75623912 |
| 112 | establishment of mitochondrion localization (GO:0051654) | 2.72723487 |
| 113 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.72517204 |
| 114 | glycerophospholipid catabolic process (GO:0046475) | 2.72431501 |
| 115 | positive regulation of dendritic spine development (GO:0060999) | 2.71978217 |
| 116 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 2.71844745 |
| 117 | serotonin receptor signaling pathway (GO:0007210) | 2.71607225 |
| 118 | neurofilament cytoskeleton organization (GO:0060052) | 2.70748980 |
| 119 | long-term memory (GO:0007616) | 2.70093049 |
| 120 | negative regulation of axon extension (GO:0030517) | 2.69955978 |
| 121 | establishment of melanosome localization (GO:0032401) | 2.69839631 |
| 122 | regulation of action potential (GO:0098900) | 2.68747135 |
| 123 | negative regulation of axon guidance (GO:1902668) | 2.68263512 |
| 124 | regulation of neurotransmitter levels (GO:0001505) | 2.68181151 |
| 125 | neuron fate determination (GO:0048664) | 2.67862301 |
| 126 | cilium movement (GO:0003341) | 2.67170331 |
| 127 | calcium ion-dependent exocytosis (GO:0017156) | 2.63364432 |
| 128 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 2.63247472 |
| 129 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.62035011 |
| 130 | regulation of respiratory system process (GO:0044065) | 2.55124041 |
| 131 | negative regulation of hormone biosynthetic process (GO:0032353) | 2.54495873 |
| 132 | establishment of pigment granule localization (GO:0051905) | 2.53736167 |
| 133 | behavioral response to nicotine (GO:0035095) | 2.53356380 |
| 134 | positive regulation of amine transport (GO:0051954) | 2.52590066 |
| 135 | urinary tract smooth muscle contraction (GO:0014848) | 2.52196944 |
| 136 | regulation of synaptic transmission, GABAergic (GO:0032228) | 2.51330999 |
| 137 | positive regulation of meiosis (GO:0045836) | 2.50923379 |
| 138 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.50661256 |
| 139 | regulation of acrosome reaction (GO:0060046) | 2.47235961 |
| 140 | acrosome reaction (GO:0007340) | 2.46310035 |
| 141 | dendritic spine organization (GO:0097061) | 2.44285918 |
| 142 | cellular ketone body metabolic process (GO:0046950) | 2.43709303 |
| 143 | positive regulation of action potential (GO:0045760) | 2.39564125 |
| 144 | brain morphogenesis (GO:0048854) | 2.38744748 |
| 145 | melanosome transport (GO:0032402) | 2.37435920 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.00382202 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 4.42444821 |
| 3 | TAF15_26573619_Chip-Seq_HEK293_Human | 3.04461088 |
| 4 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.89177001 |
| 5 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.84404046 |
| 6 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.72164586 |
| 7 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.44988492 |
| 8 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.44890755 |
| 9 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.42614104 |
| 10 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.40553725 |
| 11 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.40553725 |
| 12 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.32650015 |
| 13 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.32452851 |
| 14 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.31774007 |
| 15 | * JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.22809739 |
| 16 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.18904111 |
| 17 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.18338601 |
| 18 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.18174440 |
| 19 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.12808578 |
| 20 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.12276393 |
| 21 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.10775345 |
| 22 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 2.07724178 |
| 23 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.98681570 |
| 24 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.97717059 |
| 25 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.96698569 |
| 26 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.95913290 |
| 27 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.93602121 |
| 28 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.92580873 |
| 29 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.84639917 |
| 30 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.84632120 |
| 31 | * P300_19829295_ChIP-Seq_ESCs_Human | 1.84413795 |
| 32 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.84211407 |
| 33 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.82280237 |
| 34 | FUS_26573619_Chip-Seq_HEK293_Human | 1.77579669 |
| 35 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.76556872 |
| 36 | * SMAD4_21799915_ChIP-Seq_A2780_Human | 1.74935909 |
| 37 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.74412361 |
| 38 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.74175083 |
| 39 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.73468833 |
| 40 | * SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.71674838 |
| 41 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.71445974 |
| 42 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.67367355 |
| 43 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.66124381 |
| 44 | VDR_22108803_ChIP-Seq_LS180_Human | 1.65303187 |
| 45 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.61838640 |
| 46 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.61392054 |
| 47 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.58637555 |
| 48 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.58598588 |
| 49 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.58363343 |
| 50 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.57534707 |
| 51 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.56617826 |
| 52 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.54223543 |
| 53 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.50932238 |
| 54 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.49084086 |
| 55 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.48354837 |
| 56 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.46184821 |
| 57 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.37892389 |
| 58 | STAT3_23295773_ChIP-Seq_U87_Human | 1.36375421 |
| 59 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.35679768 |
| 60 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.33722009 |
| 61 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.32740908 |
| 62 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.32496135 |
| 63 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.32496135 |
| 64 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.30805758 |
| 65 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.28401080 |
| 66 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.28401080 |
| 67 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.27790589 |
| 68 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.27053941 |
| 69 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.26476724 |
| 70 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.25246405 |
| 71 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.23382980 |
| 72 | AR_25329375_ChIP-Seq_VCAP_Human | 1.23131157 |
| 73 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.22999505 |
| 74 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.22979946 |
| 75 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.22253966 |
| 76 | TCF4_23295773_ChIP-Seq_U87_Human | 1.21876875 |
| 77 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.21205199 |
| 78 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.20937017 |
| 79 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.18725698 |
| 80 | * UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.18114488 |
| 81 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.16436277 |
| 82 | JUN_21703547_ChIP-Seq_K562_Human | 1.16073891 |
| 83 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.13595502 |
| 84 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.13222358 |
| 85 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.12006787 |
| 86 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.10513871 |
| 87 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.10329133 |
| 88 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.09956961 |
| 89 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.08805197 |
| 90 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.08677672 |
| 91 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.08281440 |
| 92 | * EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.06846029 |
| 93 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.06786104 |
| 94 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.05967221 |
| 95 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.05498410 |
| 96 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.04096367 |
| 97 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.03173129 |
| 98 | EWS_26573619_Chip-Seq_HEK293_Human | 1.02327071 |
| 99 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.01887832 |
| 100 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.01299600 |
| 101 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.00632425 |
| 102 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.00568830 |
| 103 | * SOX9_26525672_Chip-Seq_HEART_Mouse | 1.00421112 |
| 104 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 0.99049539 |
| 105 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.98780860 |
| 106 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.98065456 |
| 107 | KDM2B_26808549_Chip-Seq_REH_Human | 0.96815681 |
| 108 | * TP53_18474530_ChIP-ChIP_U2OS_Human | 0.96780071 |
| 109 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 0.96653650 |
| 110 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.96239158 |
| 111 | AR_19668381_ChIP-Seq_PC3_Human | 0.95902851 |
| 112 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.94638959 |
| 113 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 0.94634251 |
| 114 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.94410188 |
| 115 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.93151255 |
| 116 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.91537166 |
| 117 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.91323933 |
| 118 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 0.91132785 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 5.72276699 |
| 2 | MP0004859_abnormal_synaptic_plasticity | 4.72952915 |
| 3 | MP0004270_analgesia | 3.86326849 |
| 4 | MP0003635_abnormal_synaptic_transmissio | 3.57741013 |
| 5 | MP0001984_abnormal_olfaction | 3.27466282 |
| 6 | MP0009745_abnormal_behavioral_response | 3.15552556 |
| 7 | MP0002064_seizures | 2.92923926 |
| 8 | MP0002063_abnormal_learning/memory/cond | 2.87986476 |
| 9 | MP0009046_muscle_twitch | 2.79166185 |
| 10 | MP0006276_abnormal_autonomic_nervous | 2.67432589 |
| 11 | MP0002572_abnormal_emotion/affect_behav | 2.65985262 |
| 12 | MP0005423_abnormal_somatic_nervous | 2.65653418 |
| 13 | MP0001968_abnormal_touch/_nociception | 2.60973706 |
| 14 | MP0002272_abnormal_nervous_system | 2.60805080 |
| 15 | MP0002734_abnormal_mechanical_nocicepti | 2.55418360 |
| 16 | MP0001486_abnormal_startle_reflex | 2.50832003 |
| 17 | MP0001529_abnormal_vocalization | 2.27049471 |
| 18 | MP0000566_synostosis | 2.25778826 |
| 19 | MP0000778_abnormal_nervous_system | 2.24852667 |
| 20 | MP0001501_abnormal_sleep_pattern | 2.17067900 |
| 21 | MP0002735_abnormal_chemical_nociception | 2.15810813 |
| 22 | MP0001440_abnormal_grooming_behavior | 2.15509172 |
| 23 | MP0002822_catalepsy | 2.14800532 |
| 24 | MP0002184_abnormal_innervation | 2.10664839 |
| 25 | MP0002067_abnormal_sensory_capabilities | 2.07298844 |
| 26 | MP0002736_abnormal_nociception_after | 2.04594165 |
| 27 | MP0001905_abnormal_dopamine_level | 1.94285772 |
| 28 | MP0004742_abnormal_vestibular_system | 1.90767813 |
| 29 | MP0002733_abnormal_thermal_nociception | 1.82304090 |
| 30 | MP0005645_abnormal_hypothalamus_physiol | 1.78137721 |
| 31 | MP0003329_amyloid_beta_deposits | 1.77289179 |
| 32 | MP0002638_abnormal_pupillary_reflex | 1.76637213 |
| 33 | MP0005386_behavior/neurological_phenoty | 1.76489639 |
| 34 | MP0004924_abnormal_behavior | 1.76489639 |
| 35 | MP0002557_abnormal_social/conspecific_i | 1.76267779 |
| 36 | MP0001485_abnormal_pinna_reflex | 1.75746066 |
| 37 | MP0002102_abnormal_ear_morphology | 1.72275988 |
| 38 | MP0001970_abnormal_pain_threshold | 1.66855573 |
| 39 | MP0003787_abnormal_imprinting | 1.66041367 |
| 40 | MP0002653_abnormal_ependyma_morphology | 1.65840711 |
| 41 | MP0001188_hyperpigmentation | 1.57424010 |
| 42 | MP0002882_abnormal_neuron_morphology | 1.56639016 |
| 43 | MP0003879_abnormal_hair_cell | 1.53902430 |
| 44 | MP0000569_abnormal_digit_pigmentation | 1.47962362 |
| 45 | MP0005499_abnormal_olfactory_system | 1.44956010 |
| 46 | MP0005394_taste/olfaction_phenotype | 1.44956010 |
| 47 | MP0000955_abnormal_spinal_cord | 1.41765357 |
| 48 | MP0004811_abnormal_neuron_physiology | 1.38240569 |
| 49 | MP0003718_maternal_effect | 1.36868283 |
| 50 | MP0002066_abnormal_motor_capabilities/c | 1.35890423 |
| 51 | MP0004142_abnormal_muscle_tone | 1.35285262 |
| 52 | MP0005646_abnormal_pituitary_gland | 1.34763899 |
| 53 | MP0003283_abnormal_digestive_organ | 1.31799627 |
| 54 | MP0001502_abnormal_circadian_rhythm | 1.28909289 |
| 55 | MP0008789_abnormal_olfactory_epithelium | 1.27128620 |
| 56 | MP0000920_abnormal_myelination | 1.27011298 |
| 57 | MP0004885_abnormal_endolymph | 1.26617847 |
| 58 | MP0005253_abnormal_eye_physiology | 1.24180528 |
| 59 | MP0001963_abnormal_hearing_physiology | 1.22001257 |
| 60 | MP0005551_abnormal_eye_electrophysiolog | 1.21947790 |
| 61 | MP0008569_lethality_at_weaning | 1.19048550 |
| 62 | MP0005171_absent_coat_pigmentation | 1.18406925 |
| 63 | MP0002229_neurodegeneration | 1.17516448 |
| 64 | MP0002938_white_spotting | 1.17169209 |
| 65 | MP0002752_abnormal_somatic_nervous | 1.17104602 |
| 66 | MP0002152_abnormal_brain_morphology | 1.14623425 |
| 67 | MP0002928_abnormal_bile_duct | 1.13512424 |
| 68 | MP0003122_maternal_imprinting | 1.12236834 |
| 69 | MP0003890_abnormal_embryonic-extraembry | 1.06536273 |
| 70 | MP0003011_delayed_dark_adaptation | 1.02195745 |
| 71 | MP0002234_abnormal_pharynx_morphology | 1.01507266 |
| 72 | MP0000026_abnormal_inner_ear | 0.97681747 |
| 73 | MP0003136_yellow_coat_color | 0.97201448 |
| 74 | MP0004858_abnormal_nervous_system | 0.96240899 |
| 75 | MP0002876_abnormal_thyroid_physiology | 0.95928976 |
| 76 | MP0003634_abnormal_glial_cell | 0.95908590 |
| 77 | MP0010386_abnormal_urinary_bladder | 0.94727468 |
| 78 | MP0000631_abnormal_neuroendocrine_gland | 0.93952519 |
| 79 | MP0005084_abnormal_gallbladder_morpholo | 0.93373158 |
| 80 | MP0003631_nervous_system_phenotype | 0.92727279 |
| 81 | MP0004133_heterotaxia | 0.89994969 |
| 82 | MP0009780_abnormal_chondrocyte_physiolo | 0.89761197 |
| 83 | MP0003633_abnormal_nervous_system | 0.88756339 |
| 84 | MP0003632_abnormal_nervous_system | 0.87748878 |
| 85 | MP0005195_abnormal_posterior_eye | 0.87637721 |
| 86 | MP0002837_dystrophic_cardiac_calcinosis | 0.85757479 |
| 87 | MP0004145_abnormal_muscle_electrophysio | 0.84662602 |
| 88 | MP0005409_darkened_coat_color | 0.84305303 |
| 89 | MP0008995_early_reproductive_senescence | 0.83882425 |
| 90 | MP0005187_abnormal_penis_morphology | 0.82530981 |
| 91 | MP0001324_abnormal_eye_pigmentation | 0.82083359 |
| 92 | MP0002090_abnormal_vision | 0.81146578 |
| 93 | MP0003119_abnormal_digestive_system | 0.79824174 |
| 94 | MP0000751_myopathy | 0.79447510 |
| 95 | MP0002069_abnormal_eating/drinking_beha | 0.78241735 |
| 96 | MP0003690_abnormal_glial_cell | 0.77578157 |
| 97 | MP0002233_abnormal_nose_morphology | 0.76339638 |
| 98 | MP0003123_paternal_imprinting | 0.75425281 |
| 99 | MP0003861_abnormal_nervous_system | 0.75419832 |
| 100 | MP0000049_abnormal_middle_ear | 0.74845546 |
| 101 | MP0004085_abnormal_heartbeat | 0.74209543 |
| 102 | MP0003195_calcinosis | 0.72143349 |
| 103 | MP0003698_abnormal_male_reproductive | 0.72070725 |
| 104 | MP0002751_abnormal_autonomic_nervous | 0.72054251 |
| 105 | MP0006072_abnormal_retinal_apoptosis | 0.70237692 |
| 106 | MP0008874_decreased_physiological_sensi | 0.69857038 |
| 107 | MP0006292_abnormal_olfactory_placode | 0.69689992 |
| 108 | MP0000604_amyloidosis | 0.66958110 |
| 109 | MP0008872_abnormal_physiological_respon | 0.66296070 |
| 110 | MP0003121_genomic_imprinting | 0.66151043 |
| 111 | MP0008877_abnormal_DNA_methylation | 0.65088679 |
| 112 | MP0003938_abnormal_ear_development | 0.64012373 |
| 113 | MP0002160_abnormal_reproductive_system | 0.63402728 |
| 114 | MP0002909_abnormal_adrenal_gland | 0.62324252 |
| 115 | MP0000372_irregular_coat_pigmentation | 0.59102821 |
| 116 | MP0000462_abnormal_digestive_system | 0.58907969 |
| 117 | MP0005410_abnormal_fertilization | 0.57778253 |
| 118 | MP0010770_preweaning_lethality | 0.56604002 |
| 119 | MP0002082_postnatal_lethality | 0.56604002 |
| 120 | MP0001943_abnormal_respiration | 0.56033579 |
| 121 | MP0010769_abnormal_survival | 0.54047253 |
| 122 | MP0001299_abnormal_eye_distance/ | 0.53998771 |
| 123 | MP0001664_abnormal_digestion | 0.52457231 |
| 124 | MP0001177_atelectasis | 0.52381852 |
| 125 | MP0005535_abnormal_body_temperature | 0.51987260 |
| 126 | MP0001986_abnormal_taste_sensitivity | 0.51224332 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 7.47425953 |
| 2 | Atonic seizures (HP:0010819) | 5.90044202 |
| 3 | Focal seizures (HP:0007359) | 5.30805381 |
| 4 | Febrile seizures (HP:0002373) | 4.79759526 |
| 5 | Absence seizures (HP:0002121) | 4.57998755 |
| 6 | Epileptic encephalopathy (HP:0200134) | 4.57624790 |
| 7 | Myokymia (HP:0002411) | 4.30835863 |
| 8 | Dialeptic seizures (HP:0011146) | 4.27549446 |
| 9 | Hyperventilation (HP:0002883) | 4.24595786 |
| 10 | Visual hallucinations (HP:0002367) | 3.66473733 |
| 11 | Sensory axonal neuropathy (HP:0003390) | 3.62962950 |
| 12 | Generalized tonic-clonic seizures (HP:0002069) | 3.42022987 |
| 13 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 3.34421630 |
| 14 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 3.34421630 |
| 15 | Progressive cerebellar ataxia (HP:0002073) | 3.20849212 |
| 16 | Broad-based gait (HP:0002136) | 3.16259427 |
| 17 | Abnormality of the corticospinal tract (HP:0002492) | 3.08033906 |
| 18 | Retinal dysplasia (HP:0007973) | 3.04097253 |
| 19 | Insidious onset (HP:0003587) | 3.00736415 |
| 20 | Termporal pattern (HP:0011008) | 3.00736415 |
| 21 | Gait imbalance (HP:0002141) | 2.92709533 |
| 22 | Gaze-evoked nystagmus (HP:0000640) | 2.85407807 |
| 23 | Akinesia (HP:0002304) | 2.83328319 |
| 24 | Hypoglycemic coma (HP:0001325) | 2.80587654 |
| 25 | Neurofibrillary tangles (HP:0002185) | 2.79378072 |
| 26 | Amblyopia (HP:0000646) | 2.76686597 |
| 27 | Excessive salivation (HP:0003781) | 2.72551485 |
| 28 | Drooling (HP:0002307) | 2.72551485 |
| 29 | Dysmetria (HP:0001310) | 2.68979260 |
| 30 | Limb dystonia (HP:0002451) | 2.67671297 |
| 31 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.65621428 |
| 32 | Absent speech (HP:0001344) | 2.64307077 |
| 33 | Medial flaring of the eyebrow (HP:0010747) | 2.62782423 |
| 34 | Cerebral inclusion bodies (HP:0100314) | 2.62414703 |
| 35 | Spastic gait (HP:0002064) | 2.57690207 |
| 36 | Congenital primary aphakia (HP:0007707) | 2.56117311 |
| 37 | Hypothermia (HP:0002045) | 2.55859503 |
| 38 | Supranuclear gaze palsy (HP:0000605) | 2.52411907 |
| 39 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.51542743 |
| 40 | Absent/shortened dynein arms (HP:0200106) | 2.51542743 |
| 41 | Inability to walk (HP:0002540) | 2.51411997 |
| 42 | Fetal akinesia sequence (HP:0001989) | 2.50920546 |
| 43 | Agitation (HP:0000713) | 2.48886675 |
| 44 | Abnormal ciliary motility (HP:0012262) | 2.45542694 |
| 45 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.43999228 |
| 46 | Pancreatic fibrosis (HP:0100732) | 2.43990980 |
| 47 | Genital tract atresia (HP:0001827) | 2.43530950 |
| 48 | Truncal ataxia (HP:0002078) | 2.42185757 |
| 49 | Protruding tongue (HP:0010808) | 2.42144660 |
| 50 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.41756303 |
| 51 | Nephrogenic diabetes insipidus (HP:0009806) | 2.41051285 |
| 52 | Action tremor (HP:0002345) | 2.40867706 |
| 53 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.39698866 |
| 54 | Hypsarrhythmia (HP:0002521) | 2.38218531 |
| 55 | Progressive inability to walk (HP:0002505) | 2.37469357 |
| 56 | Vaginal atresia (HP:0000148) | 2.35215575 |
| 57 | Amyotrophic lateral sclerosis (HP:0007354) | 2.32360900 |
| 58 | Abnormal eating behavior (HP:0100738) | 2.31762748 |
| 59 | Polyphagia (HP:0002591) | 2.31569417 |
| 60 | Supernumerary spleens (HP:0009799) | 2.27108876 |
| 61 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.24730588 |
| 62 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.24482495 |
| 63 | Oligodactyly (hands) (HP:0001180) | 2.24252209 |
| 64 | True hermaphroditism (HP:0010459) | 2.23745584 |
| 65 | Cortical dysplasia (HP:0002539) | 2.23082923 |
| 66 | Pancreatic cysts (HP:0001737) | 2.22375613 |
| 67 | Generalized myoclonic seizures (HP:0002123) | 2.20328682 |
| 68 | Optic nerve hypoplasia (HP:0000609) | 2.18679890 |
| 69 | Poor eye contact (HP:0000817) | 2.18586205 |
| 70 | Thickened helices (HP:0000391) | 2.16974035 |
| 71 | Scanning speech (HP:0002168) | 2.16799398 |
| 72 | Renal cortical cysts (HP:0000803) | 2.16147857 |
| 73 | Acute necrotizing encephalopathy (HP:0006965) | 2.15602303 |
| 74 | Abnormal hair whorl (HP:0010721) | 2.14946292 |
| 75 | Parakeratosis (HP:0001036) | 2.13752584 |
| 76 | Short tibia (HP:0005736) | 2.12991410 |
| 77 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.12257841 |
| 78 | Abnormality of salivation (HP:0100755) | 2.11195255 |
| 79 | Hyperglycinemia (HP:0002154) | 2.10700853 |
| 80 | Ankle clonus (HP:0011448) | 2.10252573 |
| 81 | Molar tooth sign on MRI (HP:0002419) | 2.09180029 |
| 82 | Abnormality of midbrain morphology (HP:0002418) | 2.09180029 |
| 83 | Epileptiform EEG discharges (HP:0011182) | 2.07992823 |
| 84 | Spastic tetraplegia (HP:0002510) | 2.06322095 |
| 85 | Specific learning disability (HP:0001328) | 2.06206448 |
| 86 | Pheochromocytoma (HP:0002666) | 2.05525381 |
| 87 | Dysdiadochokinesis (HP:0002075) | 2.05140000 |
| 88 | Lissencephaly (HP:0001339) | 2.03928976 |
| 89 | Hyperthyroidism (HP:0000836) | 2.03778193 |
| 90 | Blue irides (HP:0000635) | 2.02992590 |
| 91 | Pachygyria (HP:0001302) | 2.02215111 |
| 92 | Postaxial hand polydactyly (HP:0001162) | 2.00082480 |
| 93 | Failure to thrive in infancy (HP:0001531) | 1.99301923 |
| 94 | Broad foot (HP:0001769) | 1.99028735 |
| 95 | Polydipsia (HP:0001959) | 1.98474409 |
| 96 | Abnormal drinking behavior (HP:0030082) | 1.98474409 |
| 97 | Progressive macrocephaly (HP:0004481) | 1.95786092 |
| 98 | Abdominal situs inversus (HP:0003363) | 1.94291738 |
| 99 | Abnormality of abdominal situs (HP:0011620) | 1.94291738 |
| 100 | Abnormality of the renal cortex (HP:0011035) | 1.94066793 |
| 101 | Widely spaced teeth (HP:0000687) | 1.93246017 |
| 102 | Peripheral hypomyelination (HP:0007182) | 1.90919610 |
| 103 | Poor coordination (HP:0002370) | 1.89707506 |
| 104 | Decreased testicular size (HP:0008734) | 1.89316704 |
| 105 | Tubulointerstitial abnormality (HP:0001969) | 1.89254360 |
| 106 | Tubulointerstitial nephritis (HP:0001970) | 1.89164017 |
| 107 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.88852712 |
| 108 | Anxiety (HP:0000739) | 1.88606013 |
| 109 | Hypoglycemic seizures (HP:0002173) | 1.88566417 |
| 110 | Status epilepticus (HP:0002133) | 1.87400387 |
| 111 | Abnormal social behavior (HP:0012433) | 1.86747222 |
| 112 | Impaired social interactions (HP:0000735) | 1.86747222 |
| 113 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.85652684 |
| 114 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.85652684 |
| 115 | EEG with generalized epileptiform discharges (HP:0011198) | 1.84883826 |
| 116 | Hepatic necrosis (HP:0002605) | 1.84133630 |
| 117 | Methylmalonic acidemia (HP:0002912) | 1.83343478 |
| 118 | Lower limb muscle weakness (HP:0007340) | 1.83096846 |
| 119 | Muscular hypotonia of the trunk (HP:0008936) | 1.82798275 |
| 120 | Hemiparesis (HP:0001269) | 1.82029871 |
| 121 | Neuroendocrine neoplasm (HP:0100634) | 1.79692467 |
| 122 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.79561301 |
| 123 | Sclerocornea (HP:0000647) | 1.79424114 |
| 124 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.78912333 |
| 125 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.77366340 |
| 126 | Hypoplasia of the fovea (HP:0007750) | 1.77366340 |
| 127 | Genetic anticipation (HP:0003743) | 1.77289944 |
| 128 | Rhinitis (HP:0012384) | 1.76709745 |
| 129 | Abnormality of macular pigmentation (HP:0008002) | 1.76494954 |
| 130 | Abnormality of the labia minora (HP:0012880) | 1.76376641 |
| 131 | Fair hair (HP:0002286) | 1.75671663 |
| 132 | Ketoacidosis (HP:0001993) | 1.75440649 |
| 133 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.74982478 |
| 134 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.74966449 |
| 135 | Hypoplasia of the brainstem (HP:0002365) | 1.74966449 |
| 136 | Narrow forehead (HP:0000341) | 1.74612461 |
| 137 | Esotropia (HP:0000565) | 1.74246514 |
| 138 | Urinary urgency (HP:0000012) | 1.73426070 |
| 139 | Nephronophthisis (HP:0000090) | 1.73077709 |
| 140 | Autoamputation (HP:0001218) | 1.72952360 |
| 141 | Exotropia (HP:0000577) | 1.70944277 |
| 142 | Large for gestational age (HP:0001520) | 1.70394489 |
| 143 | Intellectual disability, moderate (HP:0002342) | 1.70252302 |
| 144 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.69640188 |
| 145 | Osteomalacia (HP:0002749) | 1.69112381 |
| 146 | Poor suck (HP:0002033) | 1.68876030 |
| 147 | Aplasia/Hypoplasia of the lens (HP:0008063) | 1.65153573 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CASK | 4.24551535 |
| 2 | NTRK3 | 3.54441181 |
| 3 | EPHA4 | 3.45958927 |
| 4 | TNIK | 3.28908947 |
| 5 | EPHA3 | 3.28638858 |
| 6 | STK39 | 2.75413031 |
| 7 | MAP3K4 | 2.68535599 |
| 8 | MAP2K7 | 2.67394687 |
| 9 | MARK1 | 2.51486901 |
| 10 | OXSR1 | 2.49999216 |
| 11 | MAP3K12 | 2.41150179 |
| 12 | BMPR1B | 2.39403923 |
| 13 | CDK19 | 2.38637818 |
| 14 | DAPK2 | 2.25113921 |
| 15 | MAP3K9 | 2.22202928 |
| 16 | TRIM28 | 2.19295885 |
| 17 | FRK | 2.15829131 |
| 18 | NTRK2 | 2.13521758 |
| 19 | PAK6 | 2.02419084 |
| 20 | MAP4K2 | 2.00649730 |
| 21 | MAPK13 | 1.92275436 |
| 22 | PRPF4B | 1.82233208 |
| 23 | BCR | 1.76665168 |
| 24 | MINK1 | 1.75280527 |
| 25 | MAP2K4 | 1.74762877 |
| 26 | PLK2 | 1.70398385 |
| 27 | PINK1 | 1.67121707 |
| 28 | PNCK | 1.60643791 |
| 29 | ARAF | 1.52921286 |
| 30 | KSR1 | 1.48605008 |
| 31 | NTRK1 | 1.41976529 |
| 32 | KSR2 | 1.30560571 |
| 33 | DYRK3 | 1.29470955 |
| 34 | CAMK2B | 1.28916859 |
| 35 | WNK4 | 1.28204771 |
| 36 | UHMK1 | 1.26321445 |
| 37 | CDK5 | 1.24929875 |
| 38 | GRK5 | 1.21508661 |
| 39 | DAPK1 | 1.19812989 |
| 40 | CCNB1 | 1.18167928 |
| 41 | CAMK2A | 1.17015440 |
| 42 | SIK3 | 1.15940168 |
| 43 | CSNK1G2 | 1.15937603 |
| 44 | PHKG2 | 1.09552598 |
| 45 | PHKG1 | 1.09552598 |
| 46 | PAK3 | 1.05069321 |
| 47 | CSNK1G3 | 1.01202821 |
| 48 | PASK | 0.99001893 |
| 49 | CAMKK2 | 0.98420672 |
| 50 | MAP3K6 | 0.96699017 |
| 51 | AKT3 | 0.95405903 |
| 52 | PRKCG | 0.94280308 |
| 53 | FGR | 0.94062339 |
| 54 | CDK18 | 0.93820494 |
| 55 | BMPR2 | 0.91837328 |
| 56 | SGK223 | 0.90821187 |
| 57 | SGK494 | 0.90821187 |
| 58 | TAOK3 | 0.90674724 |
| 59 | CSNK1A1L | 0.90492640 |
| 60 | SRPK1 | 0.89906490 |
| 61 | BCKDK | 0.89548998 |
| 62 | CDK14 | 0.89174672 |
| 63 | CDK15 | 0.87487483 |
| 64 | MAP3K13 | 0.84468822 |
| 65 | MUSK | 0.83011437 |
| 66 | CAMK2D | 0.82530801 |
| 67 | SIK2 | 0.79227797 |
| 68 | ROCK2 | 0.78647967 |
| 69 | PKN1 | 0.77320472 |
| 70 | RIPK4 | 0.77103074 |
| 71 | RPS6KA4 | 0.76784760 |
| 72 | CDK11A | 0.76199388 |
| 73 | GRK1 | 0.75981207 |
| 74 | BRAF | 0.73572647 |
| 75 | LIMK1 | 0.72220952 |
| 76 | MARK2 | 0.71082585 |
| 77 | PRKCE | 0.70751565 |
| 78 | WNK1 | 0.70648317 |
| 79 | CSNK1G1 | 0.70160798 |
| 80 | FGFR2 | 0.70063228 |
| 81 | NME1 | 0.69407644 |
| 82 | STK11 | 0.68787162 |
| 83 | INSRR | 0.66572157 |
| 84 | NEK6 | 0.66348731 |
| 85 | RAF1 | 0.66104759 |
| 86 | CDK3 | 0.64626121 |
| 87 | EPHB2 | 0.64094960 |
| 88 | CAMK2G | 0.63348887 |
| 89 | CAMK4 | 0.63151275 |
| 90 | DYRK1A | 0.62769968 |
| 91 | TYRO3 | 0.61060813 |
| 92 | MAPKAPK5 | 0.60328005 |
| 93 | CAMK1G | 0.59931825 |
| 94 | FES | 0.59664884 |
| 95 | MAP3K2 | 0.59488222 |
| 96 | GRK7 | 0.57273150 |
| 97 | MAPK15 | 0.57064970 |
| 98 | DYRK2 | 0.57043724 |
| 99 | ICK | 0.56750355 |
| 100 | PTK2B | 0.54998564 |
| 101 | ERBB4 | 0.53878121 |
| 102 | CSNK1D | 0.52860397 |
| 103 | PRKAA1 | 0.52720214 |
| 104 | SGK2 | 0.51892858 |
| 105 | CAMK1D | 0.51440145 |
| 106 | ADRBK1 | 0.50149715 |
| 107 | AURKA | 0.49765533 |
| 108 | SGK1 | 0.47590217 |
| 109 | LATS2 | 0.46791759 |
| 110 | CAMKK1 | 0.45801774 |
| 111 | PRKACB | 0.44838021 |
| 112 | ERBB3 | 0.44827675 |
| 113 | ADRBK2 | 0.43447421 |
| 114 | DYRK1B | 0.43045864 |
| 115 | FYN | 0.42130257 |
| 116 | MAPK7 | 0.41379633 |
| 117 | CAMK1 | 0.40451566 |
| 118 | CSNK1A1 | 0.39659436 |
| 119 | PRKD3 | 0.38112877 |
| 120 | PRKACA | 0.36297259 |
| 121 | FER | 0.35914828 |
| 122 | PRKG1 | 0.34770707 |
| 123 | MAPK12 | 0.33908007 |
| 124 | TLK1 | 0.33164780 |
| 125 | CSNK1E | 0.32708342 |
| 126 | PRKCZ | 0.32379068 |
| 127 | PRKCI | 0.32233492 |
| 128 | WNK3 | 0.32225687 |
| 129 | EPHB1 | 0.30651144 |
| 130 | RET | 0.30084009 |
| 131 | RPS6KA5 | 0.29931811 |
| 132 | PRKCA | 0.28586577 |
| 133 | PLK3 | 0.28407410 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.97522824 |
| 2 | Olfactory transduction_Homo sapiens_hsa04740 | 3.35377491 |
| 3 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.24848795 |
| 4 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.91439327 |
| 5 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 2.69807512 |
| 6 | GABAergic synapse_Homo sapiens_hsa04727 | 2.56430238 |
| 7 | Morphine addiction_Homo sapiens_hsa05032 | 2.54629844 |
| 8 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.50531525 |
| 9 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.49386486 |
| 10 | Circadian entrainment_Homo sapiens_hsa04713 | 2.43138264 |
| 11 | Protein export_Homo sapiens_hsa03060 | 2.40642950 |
| 12 | Serotonergic synapse_Homo sapiens_hsa04726 | 2.33978677 |
| 13 | Long-term potentiation_Homo sapiens_hsa04720 | 2.27721874 |
| 14 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.21671660 |
| 15 | Taste transduction_Homo sapiens_hsa04742 | 2.15890417 |
| 16 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.11323735 |
| 17 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.99607503 |
| 18 | Axon guidance_Homo sapiens_hsa04360 | 1.83947022 |
| 19 | Salivary secretion_Homo sapiens_hsa04970 | 1.82218554 |
| 20 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.72390451 |
| 21 | Long-term depression_Homo sapiens_hsa04730 | 1.67078851 |
| 22 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.59881988 |
| 23 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.57896194 |
| 24 | Insulin secretion_Homo sapiens_hsa04911 | 1.57391178 |
| 25 | Renin secretion_Homo sapiens_hsa04924 | 1.54817852 |
| 26 | Alzheimers disease_Homo sapiens_hsa05010 | 1.54650423 |
| 27 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.53901426 |
| 28 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.53240201 |
| 29 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.51945277 |
| 30 | Cocaine addiction_Homo sapiens_hsa05030 | 1.50291530 |
| 31 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.46136751 |
| 32 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.44564671 |
| 33 | Phototransduction_Homo sapiens_hsa04744 | 1.43946247 |
| 34 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.40862076 |
| 35 | Parkinsons disease_Homo sapiens_hsa05012 | 1.40021450 |
| 36 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.39697158 |
| 37 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.37901877 |
| 38 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.35611019 |
| 39 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.29364607 |
| 40 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.28761020 |
| 41 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.27625259 |
| 42 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.26528033 |
| 43 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.21171067 |
| 44 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.20066174 |
| 45 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.19317821 |
| 46 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.17377747 |
| 47 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.16152987 |
| 48 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.14264058 |
| 49 | Gap junction_Homo sapiens_hsa04540 | 1.11766633 |
| 50 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.06444636 |
| 51 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.98920795 |
| 52 | RNA degradation_Homo sapiens_hsa03018 | 0.98035777 |
| 53 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.97871262 |
| 54 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.97423980 |
| 55 | Huntingtons disease_Homo sapiens_hsa05016 | 0.96983815 |
| 56 | Peroxisome_Homo sapiens_hsa04146 | 0.94140205 |
| 57 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.91669140 |
| 58 | Basal transcription factors_Homo sapiens_hsa03022 | 0.89955652 |
| 59 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.86823608 |
| 60 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.83352927 |
| 61 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.81185442 |
| 62 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.80947437 |
| 63 | Melanogenesis_Homo sapiens_hsa04916 | 0.80851808 |
| 64 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.78820818 |
| 65 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.76776535 |
| 66 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.76737029 |
| 67 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.75651928 |
| 68 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.75581850 |
| 69 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.74398812 |
| 70 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.73492229 |
| 71 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.71436512 |
| 72 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.70798614 |
| 73 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.67389265 |
| 74 | Alcoholism_Homo sapiens_hsa05034 | 0.64458315 |
| 75 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.63116458 |
| 76 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.62302230 |
| 77 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.61334226 |
| 78 | Glioma_Homo sapiens_hsa05214 | 0.61331593 |
| 79 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.60260201 |
| 80 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.60213396 |
| 81 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.59918990 |
| 82 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.58458942 |
| 83 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.57104855 |
| 84 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.56809171 |
| 85 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.56749237 |
| 86 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.54929132 |
| 87 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.54208346 |
| 88 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.54017386 |
| 89 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.53966110 |
| 90 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.53223337 |
| 91 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.52082437 |
| 92 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.51372720 |
| 93 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.50448339 |
| 94 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.50278845 |
| 95 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.49716018 |
| 96 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.48601104 |
| 97 | Bile secretion_Homo sapiens_hsa04976 | 0.48004704 |
| 98 | Metabolic pathways_Homo sapiens_hsa01100 | 0.46203096 |
| 99 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.45594136 |
| 100 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.45519434 |
| 101 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.45119569 |
| 102 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.44214070 |
| 103 | Phagosome_Homo sapiens_hsa04145 | 0.42985883 |
| 104 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.42773192 |
| 105 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.42536101 |
| 106 | ABC transporters_Homo sapiens_hsa02010 | 0.42089509 |
| 107 | RNA polymerase_Homo sapiens_hsa03020 | 0.40166800 |
| 108 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.39738670 |
| 109 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.36399612 |
| 110 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.36305294 |
| 111 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.34609799 |
| 112 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.34394404 |
| 113 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.33860530 |
| 114 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.33581774 |
| 115 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.33528734 |
| 116 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.32469033 |
| 117 | Prion diseases_Homo sapiens_hsa05020 | 0.31799154 |
| 118 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.31693713 |
| 119 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.31198759 |
| 120 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.29952158 |
| 121 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.28361660 |
| 122 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.28102777 |
| 123 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.28071886 |
| 124 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.27759526 |
| 125 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.27034720 |
| 126 | Endocytosis_Homo sapiens_hsa04144 | 0.24789703 |
| 127 | Circadian rhythm_Homo sapiens_hsa04710 | 0.24303818 |
| 128 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.24044879 |
| 129 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.23858220 |
| 130 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.23132757 |
| 131 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.22470117 |
| 132 | Tight junction_Homo sapiens_hsa04530 | 0.22361024 |
| 133 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.21952129 |

