LINGO4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)6.63567583
2sarcoplasmic reticulum calcium ion transport (GO:0070296)6.26499217
3fructose metabolic process (GO:0006000)6.11754764
4actin-myosin filament sliding (GO:0033275)6.01492441
5muscle filament sliding (GO:0030049)6.01492441
6short-term memory (GO:0007614)5.63200095
7skeletal muscle contraction (GO:0003009)5.41912722
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.37023076
9cerebellar granule cell differentiation (GO:0021707)4.99603810
10actin-mediated cell contraction (GO:0070252)4.73709144
11regulation of memory T cell differentiation (GO:0043380)4.65086016
12regulation of relaxation of muscle (GO:1901077)4.57372882
13positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.56959027
14lymph node development (GO:0048535)4.52854134
15regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.51433714
16gamma-aminobutyric acid signaling pathway (GO:0007214)4.46476659
17regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.36480770
18C4-dicarboxylate transport (GO:0015740)4.34230257
19auditory receptor cell stereocilium organization (GO:0060088)4.24585131
20regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.24013854
21striated muscle contraction (GO:0006941)4.20456509
22skeletal muscle fiber development (GO:0048741)4.18336500
23regulation of cell communication by electrical coupling (GO:0010649)4.15821549
24behavioral response to nicotine (GO:0035095)4.15001250
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.08008584
26cellular potassium ion homeostasis (GO:0030007)4.03219611
27myotube cell development (GO:0014904)3.76507083
28Peyers patch development (GO:0048541)3.75864302
29mucosal-associated lymphoid tissue development (GO:0048537)3.75864302
30response to histamine (GO:0034776)3.62825883
31neurofilament cytoskeleton organization (GO:0060052)3.61726259
32response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.61123233
33positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.59947971
34positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.55841994
35cerebellar Purkinje cell layer development (GO:0021680)3.53588196
36relaxation of cardiac muscle (GO:0055119)3.51823727
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.51159455
38L-phenylalanine catabolic process (GO:0006559)3.51159455
39T-helper cell differentiation (GO:0042093)3.48988349
40CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.48988349
41neuromuscular synaptic transmission (GO:0007274)3.47909448
42muscle fiber development (GO:0048747)3.46022587
43oxidative phosphorylation (GO:0006119)3.45810654
44cellular response to sterol (GO:0036315)3.44548117
45metanephric tubule development (GO:0072170)3.44224948
46metanephric nephron tubule development (GO:0072234)3.44224948
47regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.43617552
48positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.42933565
49regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.41826643
50fat-soluble vitamin biosynthetic process (GO:0042362)3.40725224
51relaxation of muscle (GO:0090075)3.40339134
52cell differentiation in hindbrain (GO:0021533)3.38033588
53ionotropic glutamate receptor signaling pathway (GO:0035235)3.37117027
54response to muscle activity (GO:0014850)3.34796900
55inositol phosphate-mediated signaling (GO:0048016)3.32843780
56actin filament-based movement (GO:0030048)3.31082961
57regulation of isotype switching to IgG isotypes (GO:0048302)3.28375372
58positive regulation of muscle hypertrophy (GO:0014742)3.27930314
59positive regulation of cardiac muscle hypertrophy (GO:0010613)3.27930314
60regulation of activation of Janus kinase activity (GO:0010533)3.27866511
61very-low-density lipoprotein particle assembly (GO:0034379)3.27263764
62cellular sodium ion homeostasis (GO:0006883)3.24814860
63sleep (GO:0030431)3.23654428
64regulation of bile acid biosynthetic process (GO:0070857)3.23418443
65muscle contraction (GO:0006936)3.21246032
66L-phenylalanine metabolic process (GO:0006558)3.21151679
67erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.21151679
68valine metabolic process (GO:0006573)3.18876439
69gluconeogenesis (GO:0006094)3.18227414
70regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.15594833
71glutamate receptor signaling pathway (GO:0007215)3.14777372
72creatine metabolic process (GO:0006600)3.13916362
73regulation of potassium ion transmembrane transporter activity (GO:1901016)3.13365260
74metanephric nephron epithelium development (GO:0072243)3.11890171
75regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.10730203
76positive regulation of circadian rhythm (GO:0042753)3.10276798
77cardiac muscle contraction (GO:0060048)3.07370669
78macroautophagy (GO:0016236)3.06495295
79regulation of gamma-delta T cell activation (GO:0046643)3.05467151
80nucleotide transmembrane transport (GO:1901679)3.05192149
81NADH metabolic process (GO:0006734)3.04425777
82neuron-neuron synaptic transmission (GO:0007270)3.03195339
83musculoskeletal movement (GO:0050881)3.01541211
84multicellular organismal movement (GO:0050879)3.01541211
85peripheral nervous system neuron development (GO:0048935)3.01317262
86prepulse inhibition (GO:0060134)3.01171748
87positive regulation of synaptic transmission, GABAergic (GO:0032230)3.01143191
88regulation of gamma-delta T cell differentiation (GO:0045586)3.00719405
89plasma membrane repair (GO:0001778)2.99465169
90regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.97714549
91detection of light stimulus involved in sensory perception (GO:0050962)2.97127913
92detection of light stimulus involved in visual perception (GO:0050908)2.97127913
93regulation of potassium ion transmembrane transport (GO:1901379)2.96139381
94membrane depolarization during action potential (GO:0086010)2.95725933
95negative regulation of thymocyte apoptotic process (GO:0070244)2.95634589
96viral protein processing (GO:0019082)2.95492906
97myofibril assembly (GO:0030239)2.94813760
98alpha-beta T cell activation (GO:0046631)2.92061824
99positive regulation of steroid hormone secretion (GO:2000833)2.90898899
100glycogen catabolic process (GO:0005980)2.90651666
101CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.89470056
102positive regulation of interleukin-17 production (GO:0032740)2.89319897
103negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.88884672
104postsynaptic membrane organization (GO:0001941)2.88676011
105hexose biosynthetic process (GO:0019319)2.87999267
106negative regulation of T cell receptor signaling pathway (GO:0050860)2.87657847
107positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.87624210
108signal peptide processing (GO:0006465)2.86696913
109T cell differentiation involved in immune response (GO:0002292)2.86407587
110alpha-beta T cell differentiation involved in immune response (GO:0002293)2.86407587
111alpha-beta T cell activation involved in immune response (GO:0002287)2.86407587
112G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.85236863
113muscle system process (GO:0003012)2.84552493
114regulation of calcium ion transmembrane transport (GO:1903169)2.82900390
115regulation of calcium ion transmembrane transporter activity (GO:1901019)2.82900390
116metanephric epithelium development (GO:0072207)2.80732809
117peroxisome fission (GO:0016559)2.78348449
118plasma lipoprotein particle assembly (GO:0034377)2.77091506
119aromatic amino acid family catabolic process (GO:0009074)2.77037388
120positive regulation of heat generation (GO:0031652)2.71828263
121cerebellar Purkinje cell differentiation (GO:0021702)2.69391180
122negative regulation of glycoprotein biosynthetic process (GO:0010561)2.68209539
123regulation of timing of cell differentiation (GO:0048505)2.62870775
124positive regulation of uterine smooth muscle contraction (GO:0070474)2.62177844
125neuromuscular process controlling posture (GO:0050884)2.61686812
1263-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.58252904
127purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.58252904
128CD4-positive, alpha-beta T cell activation (GO:0035710)2.57261614
129linoleic acid metabolic process (GO:0043651)2.56768297
130regulation of cholesterol homeostasis (GO:2000188)2.52202673
131acylglycerol homeostasis (GO:0055090)2.51977024
132triglyceride homeostasis (GO:0070328)2.51977024
133regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.51584010
134interleukin-1-mediated signaling pathway (GO:0070498)2.50696287
135vitamin catabolic process (GO:0009111)2.50259713
136fat-soluble vitamin catabolic process (GO:0042363)2.50259713
137coenzyme catabolic process (GO:0009109)2.49844506
138regulation of respiratory system process (GO:0044065)2.49208712
139negative regulation of execution phase of apoptosis (GO:1900118)2.48392870
140interferon-gamma production (GO:0032609)2.48159903
141positive regulation of cell fate commitment (GO:0010455)2.46252965
142steroid catabolic process (GO:0006706)2.45080212
143neuronal action potential propagation (GO:0019227)2.44100883
144positive regulation of T-helper 1 type immune response (GO:0002827)2.42660283
145alpha-beta T cell differentiation (GO:0046632)2.42081315
146regulation of uterine smooth muscle contraction (GO:0070472)2.41512681
147negative regulation of dendrite morphogenesis (GO:0050774)2.41269363
148endocrine pancreas development (GO:0031018)2.37515261
149negative regulation of digestive system process (GO:0060457)2.37223540
150axoneme assembly (GO:0035082)2.36514545
151negative regulation of glycoprotein metabolic process (GO:1903019)2.35341236
152vitamin D metabolic process (GO:0042359)2.32292693
153positive regulation of T cell mediated cytotoxicity (GO:0001916)2.31620811
154lactate metabolic process (GO:0006089)2.29869761
155positive regulation of prostaglandin secretion (GO:0032308)2.28894731
156bile acid biosynthetic process (GO:0006699)2.26221166
157tryptophan metabolic process (GO:0006568)2.26074150
158regulation of transcription involved in cell fate commitment (GO:0060850)2.25971986
159regulation of heat generation (GO:0031650)2.25440762
160tolerance induction (GO:0002507)2.23987600
161startle response (GO:0001964)2.23914976
162regulation of fever generation (GO:0031620)2.23871653
163regulation of respiratory gaseous exchange (GO:0043576)2.22696084
164cellular response to interleukin-15 (GO:0071350)2.21714051
165purine nucleotide transport (GO:0015865)2.21670442
166adenine nucleotide transport (GO:0051503)2.20244265
167phospholipid efflux (GO:0033700)2.17420729
168indolalkylamine catabolic process (GO:0046218)2.17336585
169tryptophan catabolic process (GO:0006569)2.17336585
170indole-containing compound catabolic process (GO:0042436)2.17336585
171positive regulation of lipoprotein lipase activity (GO:0051006)2.16982175
172positive regulation of triglyceride lipase activity (GO:0061365)2.16982175
173plasma lipoprotein particle organization (GO:0071827)2.16853524
174regulation of beta-amyloid formation (GO:1902003)2.16087774
175positive regulation of osteoclast differentiation (GO:0045672)2.15848102
176positive regulation of action potential (GO:0045760)2.15342983
177purine ribonucleotide transport (GO:0015868)2.14212145
178inositol phosphate catabolic process (GO:0071545)2.14144807
179innervation (GO:0060384)2.13926642
180sterol catabolic process (GO:0016127)2.12576477
181cholesterol catabolic process (GO:0006707)2.12576477
182protein-lipid complex assembly (GO:0065005)2.11102918
183response to interleukin-15 (GO:0070672)2.10597384
184nitrogen cycle metabolic process (GO:0071941)2.10039613
185amine catabolic process (GO:0009310)2.09737445

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.72140552
2VDR_22108803_ChIP-Seq_LS180_Human3.79983836
3EZH2_22144423_ChIP-Seq_EOC_Human3.52811277
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.91492851
5GBX2_23144817_ChIP-Seq_PC3_Human2.75460536
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.26205526
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.26130921
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15376211
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12705863
10AR_21572438_ChIP-Seq_LNCaP_Human2.00400207
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.97546950
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.94646537
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.94283160
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.91808793
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90494556
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87896532
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85746519
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85701399
19LXR_22158963_ChIP-Seq_LIVER_Mouse1.81855133
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81836967
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81616562
22GATA1_22025678_ChIP-Seq_K562_Human1.80029717
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79992591
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79179961
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78748131
26DROSHA_22980978_ChIP-Seq_HELA_Human1.77492260
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77222863
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76579851
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.76011595
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.75672251
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.73825233
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72158786
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.69818357
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68756836
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68756836
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66861673
37* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65036623
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64144375
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.58872362
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.54928651
41REST_21632747_ChIP-Seq_MESCs_Mouse1.54781737
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.52403567
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51421731
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.50853332
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.50044077
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.49115543
47FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48887176
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46300210
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.44904129
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44708939
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44335136
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.42034628
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.41341340
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.40753446
55NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39818443
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.38534097
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38118618
58SMAD4_21799915_ChIP-Seq_A2780_Human1.37417987
59IGF1R_20145208_ChIP-Seq_DFB_Human1.36405987
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34693185
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31768323
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30594045
63TAF15_26573619_Chip-Seq_HEK293_Human1.29257439
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28364476
65RUNX_20019798_ChIP-Seq_JUKART_Human1.26965528
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26359980
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.24925988
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24136977
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23574231
70P300_19829295_ChIP-Seq_ESCs_Human1.23363413
71PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.23358000
72AHR_22903824_ChIP-Seq_MCF-7_Human1.22387345
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.22326357
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22055260
75TAF2_19829295_ChIP-Seq_ESCs_Human1.21630264
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21502814
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.21229079
78PPARA_22158963_ChIP-Seq_LIVER_Mouse1.19941794
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17266163
80ESR1_21235772_ChIP-Seq_MCF-7_Human1.17168870
81ELK4_26923725_Chip-Seq_MESODERM_Mouse1.16840361
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16404701
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15298359
84SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.15235353
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11592168
86IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11532276
87P53_22387025_ChIP-Seq_ESCs_Mouse1.11473239
88* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10345519
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09884849
90REST_18959480_ChIP-ChIP_MESCs_Mouse1.09380533
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.08045293
92NANOG_20526341_ChIP-Seq_ESCs_Human1.07552706
93CBX2_27304074_Chip-Seq_ESCs_Mouse1.06247135
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05438429
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05414340
96KDM2B_26808549_Chip-Seq_REH_Human1.03480507
97HTT_18923047_ChIP-ChIP_STHdh_Human1.02954086
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02808533
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02653682
100AR_25329375_ChIP-Seq_VCAP_Human1.01603283
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01349809
102NMYC_18555785_Chip-Seq_ESCs_Mouse1.00855401
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00693936
104STAT3_23295773_ChIP-Seq_U87_Human1.00628333
105CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00430705
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.00343015
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00312954
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00275924
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.00114005
110TCF4_23295773_ChIP-Seq_U87_Human0.99965048
111KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99931030
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99198520
113PRDM14_20953172_ChIP-Seq_ESCs_Human0.98697731
114STAT3_18555785_Chip-Seq_ESCs_Mouse0.98428851
115SMAD4_21741376_ChIP-Seq_EPCs_Human0.98009834
116PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97464877
117BCAT_22108803_ChIP-Seq_LS180_Human0.97242083
118RXR_22108803_ChIP-Seq_LS180_Human0.96563087
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96212264
120TP53_18474530_ChIP-ChIP_U2OS_Human0.95825845
121P300_18555785_Chip-Seq_ESCs_Mouse0.95648809
122CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95346820
123SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95122565
124ER_23166858_ChIP-Seq_MCF-7_Human0.94842294
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94735734
126RARB_27405468_Chip-Seq_BRAIN_Mouse0.94635452
127* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94377342
128NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94242830
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93636393
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93589413
131SOX2_19829295_ChIP-Seq_ESCs_Human0.93221245
132NANOG_19829295_ChIP-Seq_ESCs_Human0.93221245
133* MYC_19829295_ChIP-Seq_ESCs_Human0.92660571
134SOX2_18555785_Chip-Seq_ESCs_Mouse0.92570918
135CMYC_18555785_Chip-Seq_ESCs_Mouse0.92477172
136SMAD3_21741376_ChIP-Seq_EPCs_Human0.92458093
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90864429
138BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90763265
139FOXH1_21741376_ChIP-Seq_EPCs_Human0.90346646
140SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89814921
141OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89413447
142OCT1_27270436_Chip-Seq_PROSTATE_Human0.89397863
143STAT1_20625510_ChIP-Seq_HELA_Human0.88157802
144IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88087219
145CBP_20019798_ChIP-Seq_JUKART_Human0.88087219
146CRX_20693478_ChIP-Seq_RETINA_Mouse0.87178540
147GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.86692569
148BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85519613

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio4.97292269
2MP0003646_muscle_fatigue4.76989806
3MP0004036_abnormal_muscle_relaxation3.82677990
4MP0005365_abnormal_bile_salt3.77202795
5MP0002139_abnormal_hepatobiliary_system3.57265065
6MP0000749_muscle_degeneration3.41708643
7MP0004742_abnormal_vestibular_system3.31784472
8MP0000751_myopathy3.18642935
9MP0003195_calcinosis2.92839906
10MP0005083_abnormal_biliary_tract2.91355561
11MP0001502_abnormal_circadian_rhythm2.70153563
12MP0001188_hyperpigmentation2.62606112
13MP0002735_abnormal_chemical_nociception2.52457579
14MP0005085_abnormal_gallbladder_physiolo2.49924223
15MP0008875_abnormal_xenobiotic_pharmacok2.44499635
16MP0005620_abnormal_muscle_contractility2.31893152
17MP0001501_abnormal_sleep_pattern2.30443749
18MP0002106_abnormal_muscle_physiology2.29203565
19MP0004381_abnormal_hair_follicle2.21400042
20MP0005645_abnormal_hypothalamus_physiol2.20671222
21MP0004084_abnormal_cardiac_muscle2.14398812
22MP0000747_muscle_weakness2.03856781
23MP0008877_abnormal_DNA_methylation2.02199397
24MP0001440_abnormal_grooming_behavior2.01407214
25MP0002277_abnormal_respiratory_mucosa1.95769679
26MP0004087_abnormal_muscle_fiber1.95130525
27MP0000759_abnormal_skeletal_muscle1.93879695
28MP0006035_abnormal_mitochondrial_morpho1.93668218
29MP0004130_abnormal_muscle_cell1.89812937
30MP0005369_muscle_phenotype1.85278829
31MP0004484_altered_response_of1.85251511
32MP0004019_abnormal_vitamin_homeostasis1.85228414
33MP0004233_abnormal_muscle_weight1.78948601
34MP0003880_abnormal_central_pattern1.78376904
35MP0010386_abnormal_urinary_bladder1.77817705
36MP0009745_abnormal_behavioral_response1.76381492
37MP0004215_abnormal_myocardial_fiber1.76031424
38MP0006276_abnormal_autonomic_nervous1.73673256
39MP0000750_abnormal_muscle_regeneration1.71933484
40MP0008872_abnormal_physiological_respon1.71665469
41MP0003724_increased_susceptibility_to1.71201841
42MP0005330_cardiomyopathy1.67986662
43MP0004142_abnormal_muscle_tone1.63756731
44MP0003011_delayed_dark_adaptation1.63499429
45MP0001984_abnormal_olfaction1.63090203
46MP0002876_abnormal_thyroid_physiology1.61311710
47MP0005409_darkened_coat_color1.60727461
48MP0009046_muscle_twitch1.59485065
49MP0010329_abnormal_lipoprotein_level1.54036396
50MP0002736_abnormal_nociception_after1.50381435
51MP0008569_lethality_at_weaning1.50346633
52MP0000678_abnormal_parathyroid_gland1.49918153
53MP0003868_abnormal_feces_composition1.48028563
54MP0004043_abnormal_pH_regulation1.47309563
55MP0002272_abnormal_nervous_system1.46319224
56MP0001968_abnormal_touch/_nociception1.45631962
57MP0003137_abnormal_impulse_conducting1.43727940
58MP0005423_abnormal_somatic_nervous1.42181321
59MP0001944_abnormal_pancreas_morphology1.38757665
60MP0003635_abnormal_synaptic_transmissio1.38463988
61MP0002064_seizures1.36420515
62MP0006292_abnormal_olfactory_placode1.35674859
63MP0002557_abnormal_social/conspecific_i1.34573631
64MP0009379_abnormal_foot_pigmentation1.33185733
65MP0002837_dystrophic_cardiac_calcinosis1.32889901
66MP0004147_increased_porphyrin_level1.32163993
67MP0000003_abnormal_adipose_tissue1.32053080
68MP0002269_muscular_atrophy1.31775602
69MP0009764_decreased_sensitivity_to1.31012635
70MP0005360_urolithiasis1.31003585
71MP0002693_abnormal_pancreas_physiology1.29163465
72MP0005647_abnormal_sex_gland1.29046534
73MP0003638_abnormal_response/metabolism_1.27664564
74MP0006036_abnormal_mitochondrial_physio1.27023924
75MP0005084_abnormal_gallbladder_morpholo1.24255769
76MP0003252_abnormal_bile_duct1.22941348
77MP0002972_abnormal_cardiac_muscle1.22884646
78MP0005379_endocrine/exocrine_gland_phen1.22671500
79MP0001986_abnormal_taste_sensitivity1.22289219
80MP0004270_analgesia1.20637132
81MP0002067_abnormal_sensory_capabilities1.20477057
82MP0002332_abnormal_exercise_endurance1.19483074
83MP0001486_abnormal_startle_reflex1.19291313
84MP0005451_abnormal_body_composition1.17102687
85MP0005646_abnormal_pituitary_gland1.15102167
86MP0005220_abnormal_exocrine_pancreas1.13465560
87MP0000015_abnormal_ear_pigmentation1.13107834
88MP0005535_abnormal_body_temperature1.12503737
89MP0008874_decreased_physiological_sensi1.12031946
90MP0005075_abnormal_melanosome_morpholog1.11323099
91MP0002638_abnormal_pupillary_reflex1.09133690
92MP0002254_reproductive_system_inflammat1.07714517
93MP0002822_catalepsy1.07691640
94MP0002734_abnormal_mechanical_nocicepti1.07074637
95MP0002118_abnormal_lipid_homeostasis1.06673515
96MP0005387_immune_system_phenotype1.05231562
97MP0001790_abnormal_immune_system1.05231562
98MP0002928_abnormal_bile_duct1.04517893
99MP0005377_hearing/vestibular/ear_phenot1.01952921
100MP0003878_abnormal_ear_physiology1.01952921
101MP0002132_abnormal_respiratory_system1.00160268
102MP0001970_abnormal_pain_threshold0.99688782
103MP0002063_abnormal_learning/memory/cond0.99100872
104MP0005671_abnormal_response_to0.99017297
105MP0002572_abnormal_emotion/affect_behav0.97952140
106MP0000013_abnormal_adipose_tissue0.97826648
107MP0002733_abnormal_thermal_nociception0.97544566
108MP0004924_abnormal_behavior0.96869497
109MP0005386_behavior/neurological_phenoty0.96869497
110MP0008057_abnormal_DNA_replication0.96862059
111MP0003866_abnormal_defecation0.96534114
112MP0002138_abnormal_hepatobiliary_system0.95837239
113MP0003329_amyloid_beta_deposits0.94023036
114MP0001835_abnormal_antigen_presentation0.93524068
115MP0004859_abnormal_synaptic_plasticity0.92731766
116MP0002078_abnormal_glucose_homeostasis0.92498397
117MP0002184_abnormal_innervation0.92230430
118MP0008995_early_reproductive_senescence0.92052901
119MP0000613_abnormal_salivary_gland0.91821632
120MP0001270_distended_abdomen0.91253708
121MP0002877_abnormal_melanocyte_morpholog0.90770414
122MP0001666_abnormal_nutrient_absorption0.90520306
123MP0000465_gastrointestinal_hemorrhage0.90440151
124MP0003953_abnormal_hormone_level0.89581133
125MP0002066_abnormal_motor_capabilities/c0.87560201
126MP0002127_abnormal_cardiovascular_syste0.87446625
127MP0000955_abnormal_spinal_cord0.87317900
128MP0001661_extended_life_span0.87067237
129MP0006072_abnormal_retinal_apoptosis0.86554452
130MP0003136_yellow_coat_color0.86418323
131MP0003633_abnormal_nervous_system0.86063609
132MP0005174_abnormal_tail_pigmentation0.85978047
133MP0005551_abnormal_eye_electrophysiolog0.85103613
134MP0004885_abnormal_endolymph0.83833453
135MP0002751_abnormal_autonomic_nervous0.83469383
136MP0002229_neurodegeneration0.82649331
137MP0002933_joint_inflammation0.80444944
138MP0004085_abnormal_heartbeat0.77878922
139MP0001544_abnormal_cardiovascular_syste0.77872349
140MP0005385_cardiovascular_system_phenoty0.77872349
141MP0000566_synostosis0.77781717
142MP0003879_abnormal_hair_cell0.77389447
143MP0005334_abnormal_fat_pad0.77113460
144MP0001485_abnormal_pinna_reflex0.77055102
145MP0001664_abnormal_digestion0.77007775
146MP0001765_abnormal_ion_homeostasis0.76617698
147MP0002069_abnormal_eating/drinking_beha0.75431442
148MP0009765_abnormal_xenobiotic_induced0.75074632
149MP0005410_abnormal_fertilization0.74445778
150MP0008775_abnormal_heart_ventricle0.72979640
151MP0001881_abnormal_mammary_gland0.72856886
152MP0003763_abnormal_thymus_physiology0.72402910
153MP0005636_abnormal_mineral_homeostasis0.71379916
154MP0000579_abnormal_nail_morphology0.70996125
155MP0002108_abnormal_muscle_morphology0.70081860
156MP0003787_abnormal_imprinting0.67416245
157MP0005266_abnormal_metabolism0.64011646
158MP0003221_abnormal_cardiomyocyte_apopto0.63521168
159MP0005332_abnormal_amino_acid0.59384383

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)8.30310301
2Muscle fiber inclusion bodies (HP:0100299)8.23707903
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.85226059
4Exercise-induced myalgia (HP:0003738)6.08730517
5Type 1 muscle fiber predominance (HP:0003803)5.37449265
6Exercise-induced muscle cramps (HP:0003710)5.36158522
7Muscle hypertrophy of the lower extremities (HP:0008968)4.89210507
8Myopathic facies (HP:0002058)4.53387640
9Calf muscle hypertrophy (HP:0008981)4.34969298
10Optic neuritis (HP:0100653)4.22198286
11Retrobulbar optic neuritis (HP:0100654)4.22198286
12Dysmetric saccades (HP:0000641)4.21986955
13Distal arthrogryposis (HP:0005684)4.18152533
14Abnormality of aromatic amino acid family metabolism (HP:0004338)4.10727992
15Focal motor seizures (HP:0011153)3.99116884
16Myoglobinuria (HP:0002913)3.90692208
17EMG: myopathic abnormalities (HP:0003458)3.87992188
18Hypoglycemic seizures (HP:0002173)3.80840286
19Orchitis (HP:0100796)3.77937119
20Absence seizures (HP:0002121)3.74025139
21Symptomatic seizures (HP:0011145)3.63102680
22Rhabdomyolysis (HP:0003201)3.56418181
23Hypothermia (HP:0002045)3.54414491
24Febrile seizures (HP:0002373)3.49242133
25Scanning speech (HP:0002168)3.37040667
26Horizontal nystagmus (HP:0000666)3.32192297
27Ulnar deviation of the wrist (HP:0003049)3.30475581
28Hyperinsulinemic hypoglycemia (HP:0000825)3.27050473
29Centrally nucleated skeletal muscle fibers (HP:0003687)3.25451568
30Stomatitis (HP:0010280)3.20067170
31Bulbar palsy (HP:0001283)3.16901702
32Dysdiadochokinesis (HP:0002075)3.12287700
33Gaze-evoked nystagmus (HP:0000640)3.09976565
34Abnormality of the neuromuscular junction (HP:0003398)3.09313535
35Fatigable weakness (HP:0003473)3.09313535
36Progressive cerebellar ataxia (HP:0002073)3.05506634
37Areflexia of lower limbs (HP:0002522)3.04818837
38Round ear (HP:0100830)3.03048648
39Myositis (HP:0100614)3.00814012
40Hypoglycemic coma (HP:0001325)2.98680115
41Abnormality of skeletal muscle fiber size (HP:0012084)2.98658075
42Rimmed vacuoles (HP:0003805)2.98632452
43Hyporeflexia of lower limbs (HP:0002600)2.97137694
44Frequent falls (HP:0002359)2.96969761
45Bundle branch block (HP:0011710)2.96860872
46Abnormality of the calf musculature (HP:0001430)2.96272023
47Myotonia (HP:0002486)2.92939492
48Facial diplegia (HP:0001349)2.91209226
49Chronic hepatic failure (HP:0100626)2.86688050
50Neck muscle weakness (HP:0000467)2.83745154
51Hyperglycemia (HP:0003074)2.81404445
52Sudden death (HP:0001699)2.81285496
53Keratoconjunctivitis sicca (HP:0001097)2.72144320
54Muscle fiber splitting (HP:0003555)2.71993051
55Abnormality of the left ventricular outflow tract (HP:0011103)2.68751007
56Subaortic stenosis (HP:0001682)2.68751007
57Truncal ataxia (HP:0002078)2.68244383
58Malignant hyperthermia (HP:0002047)2.65443146
59Muscle stiffness (HP:0003552)2.59829840
60Depressed nasal tip (HP:0000437)2.57136727
61Keratoconjunctivitis (HP:0001096)2.54160573
62Submucous cleft hard palate (HP:0000176)2.52848349
63Asymmetric septal hypertrophy (HP:0001670)2.51062860
64Intestinal atresia (HP:0011100)2.50249461
65Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.50115500
66Distal lower limb muscle weakness (HP:0009053)2.45341105
67Mildly elevated creatine phosphokinase (HP:0008180)2.38812276
68Prolonged partial thromboplastin time (HP:0003645)2.38633742
69Alveolar cell carcinoma (HP:0006519)2.37740273
70Myokymia (HP:0002411)2.36763866
71Hyperventilation (HP:0002883)2.34606715
72Acute necrotizing encephalopathy (HP:0006965)2.33152724
73Genetic anticipation (HP:0003743)2.32433333
74Intrahepatic cholestasis (HP:0001406)2.30266177
75Hyperkalemia (HP:0002153)2.30047859
76Joint hemorrhage (HP:0005261)2.29253366
77Abnormal ciliary motility (HP:0012262)2.27425515
78Split foot (HP:0001839)2.26990593
79Ketoacidosis (HP:0001993)2.25706264
80Broad-based gait (HP:0002136)2.25253719
81Abnormal mitochondria in muscle tissue (HP:0008316)2.23841759
82Distal lower limb amyotrophy (HP:0008944)2.22726348
83Enlarged kidneys (HP:0000105)2.22527253
84Increased intramyocellular lipid droplets (HP:0012240)2.20909439
85Impaired smooth pursuit (HP:0007772)2.20763655
86Hypoplasia of the fovea (HP:0007750)2.19843366
87Aplasia/Hypoplasia of the fovea (HP:0008060)2.19843366
88Rhinitis (HP:0012384)2.19807150
89Heart block (HP:0012722)2.19707997
90White forelock (HP:0002211)2.18692057
91Postural tremor (HP:0002174)2.18345844
92EMG: neuropathic changes (HP:0003445)2.18099273
93Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.18095240
94Abnormal hair whorl (HP:0010721)2.17278971
95Generalized tonic-clonic seizures (HP:0002069)2.15174250
96Renal cortical cysts (HP:0000803)2.14848639
97Weak cry (HP:0001612)2.13806316
98Pulmonary infiltrates (HP:0002113)2.13338092
99Optic nerve hypoplasia (HP:0000609)2.11923306
100Absent phalangeal crease (HP:0006109)2.11359408
101Oligodactyly (hands) (HP:0001180)2.11136958
102Widely patent fontanelles and sutures (HP:0004492)2.10848600
103Generalized muscle weakness (HP:0003324)2.10658656
104Increased variability in muscle fiber diameter (HP:0003557)2.10040107
105Calcaneovalgus deformity (HP:0001848)2.09626700
106Blue irides (HP:0000635)2.09268711
107Difficulty running (HP:0009046)2.09169730
108Atonic seizures (HP:0010819)2.09087499
109Dysmetria (HP:0001310)2.08542551
110Opisthotonus (HP:0002179)2.08453787
111Exercise intolerance (HP:0003546)2.07946641
112Increased muscle lipid content (HP:0009058)2.05885098
113Progressive muscle weakness (HP:0003323)2.05683237
114Abnormality of calcium-phosphate metabolism (HP:0100530)2.05619334
115Abnormality of the intrinsic pathway (HP:0010989)2.05552236
116Impaired vibration sensation in the lower limbs (HP:0002166)2.03382833
117Enlarged epiphyses (HP:0010580)2.03118258
118Proximal amyotrophy (HP:0007126)2.01578620
119Severe combined immunodeficiency (HP:0004430)2.01456158
120Progressive inability to walk (HP:0002505)2.00607452
121Mitochondrial inheritance (HP:0001427)1.98905205
122Slow saccadic eye movements (HP:0000514)1.98884119
123Patchy hypopigmentation of hair (HP:0011365)1.96014769
124Neoplasm of the tracheobronchial system (HP:0100552)1.95360587
125Respiratory insufficiency due to muscle weakness (HP:0002747)1.95190712
126Abnormal atrioventricular conduction (HP:0005150)1.94433618
127Focal seizures (HP:0007359)1.94023167
128Acute encephalopathy (HP:0006846)1.93980393
129Hypophosphatemia (HP:0002148)1.93254179
130Osteomalacia (HP:0002749)1.92362083
131Gowers sign (HP:0003391)1.92100198
132Epileptiform EEG discharges (HP:0011182)1.91152205
133Nonprogressive disorder (HP:0003680)1.90893876
134Progressive macrocephaly (HP:0004481)1.90284691
135Ketosis (HP:0001946)1.89671170
136Type 2 muscle fiber atrophy (HP:0003554)1.89173384
137Aplasia/Hypoplasia of the tibia (HP:0005772)1.88901475
138Acne (HP:0001061)1.87607307
139EEG with generalized epileptiform discharges (HP:0011198)1.87089761
140Abnormality of saccadic eye movements (HP:0000570)1.86314710
141Lipid accumulation in hepatocytes (HP:0006561)1.85978623
142Epidermoid cyst (HP:0200040)1.85423855
143Abnormality of binocular vision (HP:0011514)1.85281083
144Diplopia (HP:0000651)1.85281083
145Ragged-red muscle fibers (HP:0003200)1.84527648
146Hypsarrhythmia (HP:0002521)1.84308448
147Easy fatigability (HP:0003388)1.81975538
148Hyperglycinuria (HP:0003108)1.81953395
149Delayed CNS myelination (HP:0002188)1.81417609
150Dialeptic seizures (HP:0011146)1.81404764
151Renal dysplasia (HP:0000110)1.81027567
152Increased hepatocellular lipid droplets (HP:0006565)1.80921797
153Increased serum pyruvate (HP:0003542)1.80721982
154Prolonged QT interval (HP:0001657)1.80614353
155Median cleft lip (HP:0000161)1.80476868
156Abnormality of fatty-acid metabolism (HP:0004359)1.80144165
157Intention tremor (HP:0002080)1.78977503
158Pancreatitis (HP:0001733)1.78265599
159Limb ataxia (HP:0002070)1.78038326
160Increased connective tissue (HP:0009025)1.77315835
161Deformed tarsal bones (HP:0008119)1.76552313
162Abnormality of the nasal septum (HP:0000419)1.75650796
163Joint swelling (HP:0001386)1.74661460
164Action tremor (HP:0002345)1.74570090
165Hypoplasia of the thymus (HP:0000778)1.74472884
166Encephalitis (HP:0002383)1.74386562
167Anorexia (HP:0002039)1.72787303
168Epileptic encephalopathy (HP:0200134)1.70298017
169Decreased circulating renin level (HP:0003351)1.69821073
170Generalized aminoaciduria (HP:0002909)1.69209152
171Abnormality of glutamine family amino acid metabolism (HP:0010902)1.68788352
172T lymphocytopenia (HP:0005403)1.68643972
173Meningitis (HP:0001287)1.68630456
174Abnormality of monocarboxylic acid metabolism (HP:0010996)1.67777436
175Thyroiditis (HP:0100646)1.67682798
176Abnormality of methionine metabolism (HP:0010901)1.67272389
177Muscle fiber atrophy (HP:0100295)1.64414114
178Abnormal respiratory motile cilium physiology (HP:0012261)1.64231861
179Conjugated hyperbilirubinemia (HP:0002908)1.63734464
180Progressive hearing impairment (HP:0001730)1.63358208
181Fetal akinesia sequence (HP:0001989)1.63277958
182Pulmonary embolism (HP:0002204)1.62575703
183Cheilitis (HP:0100825)1.61976069
184Absent rod-and cone-mediated responses on ERG (HP:0007688)1.61580352
185Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.61359411
186Abnormal platelet function (HP:0011869)1.60700421
187Impaired platelet aggregation (HP:0003540)1.60700421
188Gangrene (HP:0100758)1.60353136

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.72856014
2TAOK34.46791010
3TXK4.32617910
4INSRR3.40488868
5IRAK33.27370135
6TTN2.64012133
7MAPK152.36863423
8TNIK2.31051156
9CASK2.19869367
10NTRK32.13323432
11GRK62.12607177
12FRK2.08418476
13SGK22.02331923
14VRK21.89332923
15DAPK21.87286243
16MAP3K121.86699127
17MUSK1.84666368
18AKT31.79963144
19TEC1.79349064
20PIK3CG1.74062475
21PRPF4B1.70122593
22GRK71.63802213
23BMPR21.55757156
24SGK2231.53013730
25SGK4941.53013730
26TIE11.46073965
27ITK1.45276128
28ARAF1.39385695
29NTRK21.36806237
30TSSK61.35045299
31MST41.34424159
32BTK1.31447490
33WNK11.30342965
34MAP3K91.29474596
35TNK21.27031226
36SGK31.25632225
37STK241.21251118
38HIPK21.16877431
39MAP3K141.16513813
40VRK11.08695982
41GRK11.08218660
42MAP2K21.07135773
43YES11.06116497
44PDK21.04541961
45EPHA41.04499713
46SIK31.04391565
47NEK61.00233732
48MAP2K40.99332521
49LIMK10.97946772
50IRAK40.97700978
51SIK10.95233162
52EIF2AK20.92500624
53JAK10.91524833
54NEK10.90836692
55WNK40.90172349
56MKNK20.89054686
57IKBKE0.87858887
58PASK0.86320014
59LMTK20.84617884
60ADRBK20.83373175
61SYK0.82967900
62MAPK130.81808433
63TESK10.81041102
64PRKCQ0.80534089
65RPS6KB10.79893736
66MAP2K70.78742098
67MAP3K20.77687779
68CAMKK20.77060238
69TRPM70.75015977
70MAP3K130.74359826
71MYLK0.72269123
72PINK10.71332993
73TAOK20.70961854
74PRKAA10.70822580
75SIK20.70516388
76PRKCE0.67178551
77MARK10.66763696
78MAPKAPK30.66709405
79ZAP700.65560454
80CDC42BPA0.64231036
81GRK50.64036314
82PDK10.63711110
83CDK30.63416445
84JAK30.61496265
85PHKG20.60827879
86PHKG10.60827879
87LATS10.60565254
88ZAK0.60075126
89IKBKB0.59593861
90ERBB30.59587418
91ERBB40.58022000
92CAMK10.57933011
93NUAK10.57842033
94CSNK1A1L0.54081639
95FGFR30.53797467
96MAPK40.53712447
97IGF1R0.51905028
98MST1R0.51853310
99CHUK0.51471937
100MAP4K10.51374928
101MAPK70.51304859
102MAP3K70.50992061
103WNK30.48664940
104PRKACA0.47789049
105DYRK1A0.46514302
106MAP3K40.45460895
107CAMK40.44713070
108RPS6KA30.44559359
109IRAK10.44548346
110TBK10.43706117
111CSK0.43596927
112PRKG10.43409447
113CAMK2G0.42989419
114SGK10.42946733
115PRKAA20.41376563
116PRKCG0.41270365
117CSNK1G30.41194381
118KIT0.41118362
119PRKCA0.39574388
120FGFR40.39232378
121NME10.38846447
122MAP2K30.38755551
123PKN10.38237940
124IRAK20.38027981
125FES0.37917560
126MAP2K60.37649805
127PRKCH0.37257298
128CSNK1G10.36157124
129CAMK1G0.35819781
130JAK20.35245916
131CAMKK10.35051309
132LCK0.34844095
133MAPK120.34266398
134BRAF0.33978620
135PRKACG0.33843784
136MINK10.33222787
137CAMK2A0.33147626
138FER0.33105140
139UHMK10.32387655
140PIK3CA0.32246564
141CAMK2D0.32117482
142CDK50.31222669
143MAPK30.31183514
144EIF2AK30.30355312
145CSNK1G20.27572681
146MAP4K20.24369347
147FYN0.23795442
148CSNK1D0.23358361
149CSNK1A10.22893309
150PRKG20.22261509

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.05898412
2Circadian rhythm_Homo sapiens_hsa047103.76536097
3Cardiac muscle contraction_Homo sapiens_hsa042603.34849824
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.67347904
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.36181637
6Sulfur metabolism_Homo sapiens_hsa009202.30348483
7Nitrogen metabolism_Homo sapiens_hsa009102.15654853
8Oxidative phosphorylation_Homo sapiens_hsa001902.13764884
9Steroid biosynthesis_Homo sapiens_hsa001002.10336819
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.07150014
11Fructose and mannose metabolism_Homo sapiens_hsa000512.01134709
12Alzheimers disease_Homo sapiens_hsa050101.96373613
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.85786891
14Parkinsons disease_Homo sapiens_hsa050121.79539100
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72990862
16Protein export_Homo sapiens_hsa030601.69136363
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.68823851
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.68546837
19Insulin secretion_Homo sapiens_hsa049111.68184608
20Histidine metabolism_Homo sapiens_hsa003401.67412454
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.58504629
22ABC transporters_Homo sapiens_hsa020101.55524581
23Nicotine addiction_Homo sapiens_hsa050331.49110262
24Pentose phosphate pathway_Homo sapiens_hsa000301.47987063
25Peroxisome_Homo sapiens_hsa041461.43978474
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42956238
27Arginine biosynthesis_Homo sapiens_hsa002201.36605390
28Morphine addiction_Homo sapiens_hsa050321.31190711
29Fatty acid degradation_Homo sapiens_hsa000711.30343255
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30293305
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28261827
32Dilated cardiomyopathy_Homo sapiens_hsa054141.28255915
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.26296001
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.25125203
35Primary immunodeficiency_Homo sapiens_hsa053401.23280297
36Taste transduction_Homo sapiens_hsa047421.22792354
37Renin secretion_Homo sapiens_hsa049241.22490871
38Dopaminergic synapse_Homo sapiens_hsa047281.22071235
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20444216
40Oxytocin signaling pathway_Homo sapiens_hsa049211.19801661
41beta-Alanine metabolism_Homo sapiens_hsa004101.18958071
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18390829
43GABAergic synapse_Homo sapiens_hsa047271.18084415
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16799907
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16575638
46Chemical carcinogenesis_Homo sapiens_hsa052041.13951320
47Fatty acid elongation_Homo sapiens_hsa000621.13695881
48Tryptophan metabolism_Homo sapiens_hsa003801.13249077
49Butanoate metabolism_Homo sapiens_hsa006501.11749547
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10831657
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08969632
52PPAR signaling pathway_Homo sapiens_hsa033201.08298825
53Circadian entrainment_Homo sapiens_hsa047131.06099601
54Phototransduction_Homo sapiens_hsa047441.04854041
55Carbon metabolism_Homo sapiens_hsa012001.02778685
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02111663
57Bile secretion_Homo sapiens_hsa049761.00097013
58Huntingtons disease_Homo sapiens_hsa050160.99405777
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99254619
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98960884
61Phenylalanine metabolism_Homo sapiens_hsa003600.98621028
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97797587
63Cocaine addiction_Homo sapiens_hsa050300.94466427
64Synaptic vesicle cycle_Homo sapiens_hsa047210.94439033
65Glutamatergic synapse_Homo sapiens_hsa047240.93801978
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93698506
67Pancreatic secretion_Homo sapiens_hsa049720.92741760
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.91360974
69Amphetamine addiction_Homo sapiens_hsa050310.90087918
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89858905
71Tyrosine metabolism_Homo sapiens_hsa003500.89520035
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88992606
73Retinol metabolism_Homo sapiens_hsa008300.88238579
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87644438
75RNA polymerase_Homo sapiens_hsa030200.86031558
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84872518
77Complement and coagulation cascades_Homo sapiens_hsa046100.84664851
78Fat digestion and absorption_Homo sapiens_hsa049750.83537025
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79542901
80Pyruvate metabolism_Homo sapiens_hsa006200.79121273
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78552492
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77805210
83Calcium signaling pathway_Homo sapiens_hsa040200.77698267
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77621987
85Fatty acid metabolism_Homo sapiens_hsa012120.77573975
86Salivary secretion_Homo sapiens_hsa049700.74722969
87Starch and sucrose metabolism_Homo sapiens_hsa005000.74091524
88Cholinergic synapse_Homo sapiens_hsa047250.72361352
89T cell receptor signaling pathway_Homo sapiens_hsa046600.71826637
90Olfactory transduction_Homo sapiens_hsa047400.69852368
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68515488
92Vitamin digestion and absorption_Homo sapiens_hsa049770.68270296
93Regulation of autophagy_Homo sapiens_hsa041400.67739611
94Glucagon signaling pathway_Homo sapiens_hsa049220.66748055
95Folate biosynthesis_Homo sapiens_hsa007900.64409238
96Long-term potentiation_Homo sapiens_hsa047200.63446659
97Type II diabetes mellitus_Homo sapiens_hsa049300.62825694
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62340598
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61126019
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61076296
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60976840
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60847644
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.60039571
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59400256
105Prion diseases_Homo sapiens_hsa050200.59226214
106Thyroid hormone synthesis_Homo sapiens_hsa049180.59063279
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56811631
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56609941
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.55487109
110cAMP signaling pathway_Homo sapiens_hsa040240.54853145
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54682223
112Long-term depression_Homo sapiens_hsa047300.54363529
113Serotonergic synapse_Homo sapiens_hsa047260.53472536
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52634686
115Arginine and proline metabolism_Homo sapiens_hsa003300.52490735
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.52392984
117Gastric acid secretion_Homo sapiens_hsa049710.52255840
118Propanoate metabolism_Homo sapiens_hsa006400.50555217
119Linoleic acid metabolism_Homo sapiens_hsa005910.49581390
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48794118
121Inositol phosphate metabolism_Homo sapiens_hsa005620.48327025
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48297758
123Mineral absorption_Homo sapiens_hsa049780.46482800
124Ovarian steroidogenesis_Homo sapiens_hsa049130.46307495
125Lysine degradation_Homo sapiens_hsa003100.46053303
126Oocyte meiosis_Homo sapiens_hsa041140.45821787
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44960333
128Type I diabetes mellitus_Homo sapiens_hsa049400.44721416
129Melanogenesis_Homo sapiens_hsa049160.44211378
130Prolactin signaling pathway_Homo sapiens_hsa049170.42466593
131Biosynthesis of amino acids_Homo sapiens_hsa012300.40770275
132Vibrio cholerae infection_Homo sapiens_hsa051100.40725170
133Estrogen signaling pathway_Homo sapiens_hsa049150.39018827
134ErbB signaling pathway_Homo sapiens_hsa040120.38914152
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38711479
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.36575560
137GnRH signaling pathway_Homo sapiens_hsa049120.32871148
138Insulin signaling pathway_Homo sapiens_hsa049100.32832412
139Insulin resistance_Homo sapiens_hsa049310.31990010
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.30358489
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.30299600
142Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30129967
143Gap junction_Homo sapiens_hsa045400.29014199
144Basal transcription factors_Homo sapiens_hsa030220.23917904
145MAPK signaling pathway_Homo sapiens_hsa040100.22154656
146Glycerolipid metabolism_Homo sapiens_hsa005610.19229326

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