LIPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycosphingolipid catabolic process (GO:0046479)6.91640422
2oligosaccharide catabolic process (GO:0009313)6.30780025
3glycolipid catabolic process (GO:0019377)6.26456777
4ceramide catabolic process (GO:0046514)5.57143211
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.43620944
6modulation by symbiont of host immune response (GO:0052553)5.43620944
7positive regulation by symbiont of host defense response (GO:0052509)5.43620944
8modulation by symbiont of host defense response (GO:0052031)5.43620944
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.43620944
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.43620944
11cellular extravasation (GO:0045123)5.04513851
12virion attachment to host cell (GO:0019062)4.97253620
13adhesion of symbiont to host cell (GO:0044650)4.97253620
14regulation of interferon-beta biosynthetic process (GO:0045357)4.85126562
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.81001803
16positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.79738305
17amino sugar catabolic process (GO:0046348)4.73699608
18positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.58312794
19adhesion of symbiont to host (GO:0044406)4.44878990
20membrane lipid catabolic process (GO:0046466)4.25858224
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.24379057
22positive regulation of mast cell activation (GO:0033005)4.21022166
23sphingolipid catabolic process (GO:0030149)4.15241640
24neutrophil activation involved in immune response (GO:0002283)4.12692222
25positive regulation of interferon-alpha production (GO:0032727)4.09444119
26apoptotic cell clearance (GO:0043277)4.08749570
27regulation of cholesterol storage (GO:0010885)4.01162531
28macrophage activation involved in immune response (GO:0002281)3.97060600
29plasma lipoprotein particle clearance (GO:0034381)3.95030303
30low-density lipoprotein particle clearance (GO:0034383)3.88545137
31positive regulation of cellular amide metabolic process (GO:0034250)3.86679142
32positive regulation of monocyte chemotaxis (GO:0090026)3.85834847
33regulation of interferon-alpha production (GO:0032647)3.85573649
34peptidyl-glutamic acid carboxylation (GO:0017187)3.85153445
35protein carboxylation (GO:0018214)3.85153445
36positive regulation of leukocyte degranulation (GO:0043302)3.80156985
37positive regulation of gamma-delta T cell activation (GO:0046645)3.78992957
38positive regulation of mast cell degranulation (GO:0043306)3.76098694
39positive regulation of mast cell activation involved in immune response (GO:0033008)3.76098694
40aldehyde catabolic process (GO:0046185)3.70089408
41positive regulation of bone remodeling (GO:0046852)3.63582421
42positive regulation of bone resorption (GO:0045780)3.63582421
43alpha-linolenic acid metabolic process (GO:0036109)3.59729489
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.53755624
45L-phenylalanine catabolic process (GO:0006559)3.53755624
46response to host immune response (GO:0052572)3.50748191
47response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.50748191
48peptide catabolic process (GO:0043171)3.48862846
49negative regulation of interleukin-12 production (GO:0032695)3.45860733
50barbed-end actin filament capping (GO:0051016)3.45582226
51fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.44273366
52eosinophil chemotaxis (GO:0048245)3.43265511
53complement activation, alternative pathway (GO:0006957)3.43208596
54regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.42072237
55mannose metabolic process (GO:0006013)3.40732032
56erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.37937555
57L-phenylalanine metabolic process (GO:0006558)3.37937555
58T-helper 1 type immune response (GO:0042088)3.33693937
59respiratory burst (GO:0045730)3.33640143
60aromatic amino acid family catabolic process (GO:0009074)3.32390762
61osteoclast differentiation (GO:0030316)3.29947965
62myeloid dendritic cell differentiation (GO:0043011)3.29172803
63regulation of mast cell degranulation (GO:0043304)3.28468710
64protein localization to endosome (GO:0036010)3.26615155
65immunoglobulin mediated immune response (GO:0016064)3.23072257
66regulation of mast cell activation (GO:0033003)3.22648353
67cholesterol efflux (GO:0033344)3.20878451
68angiotensin maturation (GO:0002003)3.20800235
69positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.20098442
70urea cycle (GO:0000050)3.18797494
71urea metabolic process (GO:0019627)3.18797494
72regulation of leukocyte degranulation (GO:0043300)3.14421152
73keratan sulfate catabolic process (GO:0042340)3.12809840
74microglial cell activation (GO:0001774)3.12325998
75response to host (GO:0075136)3.12129418
76response to host defenses (GO:0052200)3.12129418
77response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.12129418
78phospholipid efflux (GO:0033700)3.11211879
79bile acid biosynthetic process (GO:0006699)3.10395964
80hydrogen peroxide biosynthetic process (GO:0050665)3.10315510
81eosinophil migration (GO:0072677)3.10271994
82N-acetylneuraminate metabolic process (GO:0006054)3.10110823
83high-density lipoprotein particle remodeling (GO:0034375)3.10095939
84detection of other organism (GO:0098543)3.08757529
85tryptophan catabolic process (GO:0006569)3.06657989
86indole-containing compound catabolic process (GO:0042436)3.06657989
87indolalkylamine catabolic process (GO:0046218)3.06657989
88regulation of interleukin-8 biosynthetic process (GO:0045414)3.06475590
89fat-soluble vitamin biosynthetic process (GO:0042362)3.06138109
90regulation of cholesterol esterification (GO:0010872)3.05346111
91positive regulation of blood coagulation (GO:0030194)3.04522027
92positive regulation of hemostasis (GO:1900048)3.04522027
93positive regulation of coagulation (GO:0050820)3.04255609
94myeloid dendritic cell activation (GO:0001773)3.03687738
95ganglioside metabolic process (GO:0001573)3.03605699
96tryptophan metabolic process (GO:0006568)3.03560445
97plasma lipoprotein particle remodeling (GO:0034369)3.03517440
98protein-lipid complex remodeling (GO:0034368)3.03517440
99macromolecular complex remodeling (GO:0034367)3.03517440
100regulation of mast cell activation involved in immune response (GO:0033006)3.02632500
101lipoprotein transport (GO:0042953)3.02422511
102glyoxylate metabolic process (GO:0046487)3.02351013
103regulation of superoxide anion generation (GO:0032928)3.02250429
104positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.01423219
105regulation of triglyceride catabolic process (GO:0010896)3.00111453
106positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.99736856
107regulation of monocyte chemotaxis (GO:0090025)2.97942994
108positive regulation of macrophage cytokine production (GO:0060907)2.97289250
109regulation of protein activation cascade (GO:2000257)2.96387430
110response to peptidoglycan (GO:0032494)2.96236949
111reverse cholesterol transport (GO:0043691)2.95764878
112lipoxygenase pathway (GO:0019372)2.95376641
113kynurenine metabolic process (GO:0070189)2.95174356
114regulation of mononuclear cell migration (GO:0071675)2.95061835
115regulation of apoptotic cell clearance (GO:2000425)2.93858158
116nitrogen cycle metabolic process (GO:0071941)2.89438587
117negative regulation of fibrinolysis (GO:0051918)2.88720121
118macrophage differentiation (GO:0030225)2.88563749
119cysteine metabolic process (GO:0006534)2.87232276
120intracellular pH reduction (GO:0051452)2.86804473
121regulation of myeloid leukocyte mediated immunity (GO:0002886)2.85593051
122negative regulation of lipid storage (GO:0010888)2.84376385
123regulation of B cell receptor signaling pathway (GO:0050855)2.84053761
124macrophage activation (GO:0042116)2.83519372
125positive regulation of lipid storage (GO:0010884)2.83291004
126positive regulation of B cell differentiation (GO:0045579)2.82836435
127regulation of complement activation (GO:0030449)2.82550811
128detection of external biotic stimulus (GO:0098581)2.80654240
129detection of molecule of bacterial origin (GO:0032490)2.80476201
130glucosamine-containing compound catabolic process (GO:1901072)2.80327541
131negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.80067146
132cofactor catabolic process (GO:0051187)2.79622231
133myeloid cell activation involved in immune response (GO:0002275)2.79193331
134sulfur amino acid catabolic process (GO:0000098)2.78962422
135fibrinolysis (GO:0042730)2.78959612
136regulation of hypersensitivity (GO:0002883)2.78884146
137regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78567853
138positive regulation of tissue remodeling (GO:0034105)2.77661016
139regulation of T-helper 2 cell differentiation (GO:0045628)2.76315444
140plasma lipoprotein particle assembly (GO:0034377)2.76299522
141negative regulation of interleukin-17 production (GO:0032700)2.74680059
142negative regulation of nitric oxide biosynthetic process (GO:0045019)2.74197475
143glucuronate metabolic process (GO:0019585)2.73832721
144uronic acid metabolic process (GO:0006063)2.73832721
145reactive oxygen species biosynthetic process (GO:1903409)2.73201090
146regulation of sequestering of triglyceride (GO:0010889)2.73022292
147positive regulation of antigen processing and presentation (GO:0002579)2.72167360
148phospholipid homeostasis (GO:0055091)2.72145934
149pH reduction (GO:0045851)2.72015243
150positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.71293382
151low-density lipoprotein particle remodeling (GO:0034374)2.71072749
152pinocytosis (GO:0006907)2.70804658
153regulation of monocyte differentiation (GO:0045655)2.70444261
154regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.70362530
155bile acid metabolic process (GO:0008206)2.70307264
156detection of bacterium (GO:0016045)2.69839318
157iron ion import (GO:0097286)2.69787813
158phagosome maturation (GO:0090382)2.69595864
159response to thyroid hormone (GO:0097066)2.69371358
160production of molecular mediator involved in inflammatory response (GO:0002532)2.68867757
161positive regulation of lipid catabolic process (GO:0050996)2.68116113
162positive regulation of cholesterol efflux (GO:0010875)2.68031843
163lysosome organization (GO:0007040)2.67709464
164lytic vacuole organization (GO:0080171)2.67709464
165protein-lipid complex assembly (GO:0065005)2.67610368
166positive regulation of interferon-beta production (GO:0032728)2.66746349
167dendritic cell differentiation (GO:0097028)2.66625616
168lipoprotein metabolic process (GO:0042157)2.65352234
169regulation of fibrinolysis (GO:0051917)2.65316022
170plasma lipoprotein particle organization (GO:0071827)2.65268021
171monocyte chemotaxis (GO:0002548)2.64657530
172granulocyte activation (GO:0036230)2.63833834
173cellular response to thyroid hormone stimulus (GO:0097067)2.61594852
174interferon-gamma-mediated signaling pathway (GO:0060333)2.61252196
175homocysteine metabolic process (GO:0050667)2.61249596
176protein-lipid complex subunit organization (GO:0071825)2.60934416
177response to muramyl dipeptide (GO:0032495)2.58701611
178lipopolysaccharide-mediated signaling pathway (GO:0031663)2.57996312
179amyloid precursor protein catabolic process (GO:0042987)2.57051088
180very-low-density lipoprotein particle assembly (GO:0034379)2.56851131
181regulation of membrane protein ectodomain proteolysis (GO:0051043)2.55319587
182epithelial cell differentiation involved in prostate gland development (GO:0060742)2.54645363

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.04806459
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.39765205
3* IRF8_22096565_ChIP-ChIP_GC-B_Human4.94915098
4* RXR_22158963_ChIP-Seq_LIVER_Mouse4.45104346
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.37754504
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.93376835
7* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.74448138
8* IRF8_27001747_Chip-Seq_BMDM_Mouse3.71871064
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.67308843
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.58008088
11EGR1_23403033_ChIP-Seq_LIVER_Mouse3.51848967
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.24508524
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.20547934
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.85901529
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.76700068
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.51123312
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.45233780
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.43492011
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.43167274
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40290310
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.29840088
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.24565574
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.03118575
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03115564
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.01696370
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84154358
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.80374348
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74522061
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.73752839
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.69186245
31* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69112147
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67248114
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62507806
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62117457
35GATA1_22025678_ChIP-Seq_K562_Human1.57240875
36CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53795541
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.50259121
38PU_27001747_Chip-Seq_BMDM_Mouse1.49560952
39VDR_24787735_ChIP-Seq_THP-1_Human1.44780628
40CLOCK_20551151_ChIP-Seq_293T_Human1.44563017
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44474556
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44371037
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43730344
44SPI1_23547873_ChIP-Seq_NB4_Human1.42954646
45CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42176360
46CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40643129
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38188374
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31686807
49* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31668325
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.31389971
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.29688008
52SPI1_23127762_ChIP-Seq_K562_Human1.28173784
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.28002489
54* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.24524635
55RUNX_20019798_ChIP-Seq_JUKART_Human1.24110852
56SCL_19346495_ChIP-Seq_HPC-7_Human1.22694898
57VDR_24763502_ChIP-Seq_THP-1_Human1.22216922
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21579844
59CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20821575
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19891695
61* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19544795
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17884193
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17884193
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16917264
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11233360
66MAF_26560356_Chip-Seq_TH1_Human1.06375102
67MYB_26560356_Chip-Seq_TH2_Human1.05726561
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03474590
69PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01906444
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00982266
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00495011
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99209695
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98467408
74FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96505665
75* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95735362
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95673637
77GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93777692
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93091608
79FOXO3_23340844_ChIP-Seq_DLD1_Human0.92867190
80ESR1_21235772_ChIP-Seq_MCF-7_Human0.91223297
81GATA3_26560356_Chip-Seq_TH2_Human0.91058616
82VDR_21846776_ChIP-Seq_THP-1_Human0.90598196
83SOX2_20726797_ChIP-Seq_SW620_Human0.90116888
84SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89376198
85* FOXA2_19822575_ChIP-Seq_HepG2_Human0.89120623
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88771696
87MYB_26560356_Chip-Seq_TH1_Human0.88739292
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87990447
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87810419
90ESR2_21235772_ChIP-Seq_MCF-7_Human0.87779433
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.85681764
92TRIM28_21343339_ChIP-Seq_HEK293_Human0.85361135
93SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84767650
94TFEB_21752829_ChIP-Seq_HELA_Human0.84525508
95* GATA2_19941826_ChIP-Seq_K562_Human0.83698225
96EGR1_19032775_ChIP-ChIP_M12_Human0.83123747
97GATA1_19941827_ChIP-Seq_MEL_Mouse0.82857485
98* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82168589
99* GATA1_19941826_ChIP-Seq_K562_Human0.81222266
100CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80231307
101GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80142126
102* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79721928
103CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79705391
104* GATA3_27048872_Chip-Seq_THYMUS_Human0.79538567
105KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79326218
106PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79256063
107PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78439097
108GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78083469
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77694424
110* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.77112727
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77096732
112TCF7_22412390_ChIP-Seq_EML_Mouse0.76602509
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76458411
114UTX_26944678_Chip-Seq_JUKART_Human0.75544891
115* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75500731
116LXR_22292898_ChIP-Seq_THP-1_Human0.75468314
117* GATA4_25053715_ChIP-Seq_YYC3_Human0.74353493

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.16190076
2MP0005360_urolithiasis4.08699234
3MP0005058_abnormal_lysosome_morphology3.86408143
4MP0009840_abnormal_foam_cell3.49491651
5MP0003191_abnormal_cellular_cholesterol3.02213319
6MP0001835_abnormal_antigen_presentation2.95738411
7MP0005365_abnormal_bile_salt2.94172202
8MP0003436_decreased_susceptibility_to2.92733724
9MP0006082_CNS_inflammation2.91753658
10MP0005085_abnormal_gallbladder_physiolo2.76710919
11MP0003303_peritoneal_inflammation2.64554429
12MP0008875_abnormal_xenobiotic_pharmacok2.62051446
13MP0003172_abnormal_lysosome_physiology2.49759412
14MP0002419_abnormal_innate_immunity2.40996777
15MP0003195_calcinosis2.21357232
16MP0009785_altered_susceptibility_to2.16201991
17MP0005083_abnormal_biliary_tract2.11806958
18* MP0010329_abnormal_lipoprotein_level2.06556705
19MP0000604_amyloidosis2.06180744
20MP0003252_abnormal_bile_duct1.98545326
21MP0005000_abnormal_immune_tolerance1.97063675
22MP0003724_increased_susceptibility_to1.95718839
23MP0005025_abnormal_response_to1.93170238
24MP0003690_abnormal_glial_cell1.91995982
25MP0002148_abnormal_hypersensitivity_rea1.88508384
26MP0008004_abnormal_stomach_pH1.86094800
27MP0005464_abnormal_platelet_physiology1.84157868
28MP0003329_amyloid_beta_deposits1.71943615
29MP0003806_abnormal_nucleotide_metabolis1.67257382
30MP0002877_abnormal_melanocyte_morpholog1.65705826
31MP0002452_abnormal_antigen_presenting1.65703910
32MP0001790_abnormal_immune_system1.64873693
33MP0005387_immune_system_phenotype1.64873693
34MP0008469_abnormal_protein_level1.64599586
35MP0009764_decreased_sensitivity_to1.63448850
36MP0001533_abnormal_skeleton_physiology1.58583765
37MP0003705_abnormal_hypodermis_morpholog1.56273258
38* MP0000609_abnormal_liver_physiology1.55073529
39MP0005332_abnormal_amino_acid1.53709071
40MP0003279_aneurysm1.52301309
41MP0003656_abnormal_erythrocyte_physiolo1.52231498
42MP0003300_gastrointestinal_ulcer1.51468881
43MP0002723_abnormal_immune_serum1.50410217
44MP0008438_abnormal_cutaneous_collagen1.46810074
45MP0001800_abnormal_humoral_immune1.46688171
46MP0000685_abnormal_immune_system1.46397915
47MP0003186_abnormal_redox_activity1.45942675
48MP0004019_abnormal_vitamin_homeostasis1.45268457
49* MP0001845_abnormal_inflammatory_respons1.40578553
50MP0003828_pulmonary_edema1.39783966
51MP0002138_abnormal_hepatobiliary_system1.36624050
52MP0005257_abnormal_intraocular_pressure1.35916016
53MP0003075_altered_response_to1.35618799
54MP0005319_abnormal_enzyme/_coenzyme1.34845521
55* MP0002118_abnormal_lipid_homeostasis1.31938239
56MP0004947_skin_inflammation1.31451025
57MP0000343_altered_response_to1.29510651
58MP0001819_abnormal_immune_cell1.28481228
59MP0002420_abnormal_adaptive_immunity1.26714202
60MP0005671_abnormal_response_to1.26374754
61MP0005166_decreased_susceptibility_to1.23169434
62MP0004510_myositis1.22456488
63MP0005584_abnormal_enzyme/coenzyme_acti1.21442717
64MP0002998_abnormal_bone_remodeling1.20392384
65MP0003448_altered_tumor_morphology1.20299623
66MP0001853_heart_inflammation1.20171131
67MP0009763_increased_sensitivity_to1.18905765
68MP0001666_abnormal_nutrient_absorption1.17593384
69MP0003091_abnormal_cell_migration1.17219554
70MP0005647_abnormal_sex_gland1.15923971
71MP0005451_abnormal_body_composition1.14193317
72MP0009643_abnormal_urine_homeostasis1.13926065
73MP0002254_reproductive_system_inflammat1.13552064
74MP0004130_abnormal_muscle_cell1.12956392
75MP0010234_abnormal_vibrissa_follicle1.11474661
76MP0000015_abnormal_ear_pigmentation1.09893604
77MP0005167_abnormal_blood-brain_barrier1.09561872
78MP0000371_diluted_coat_color1.08492157
79MP0008260_abnormal_autophagy1.06483368
80MP0000569_abnormal_digit_pigmentation1.05439590
81MP0006054_spinal_hemorrhage1.02715571
82* MP0002405_respiratory_system_inflammati1.02622565
83MP0003011_delayed_dark_adaptation1.01738603
84* MP0000598_abnormal_liver_morphology1.00934124
85MP0003453_abnormal_keratinocyte_physiol0.99585229
86MP0010155_abnormal_intestine_physiology0.92734064
87MP0002136_abnormal_kidney_physiology0.92391275
88MP0003566_abnormal_cell_adhesion0.92059459
89MP0005164_abnormal_response_to0.91706416
90MP0002090_abnormal_vision0.91300943
91MP0000858_altered_metastatic_potential0.91089563
92MP0005165_increased_susceptibility_to0.90126832
93* MP0000716_abnormal_immune_system0.87147596
94MP0001727_abnormal_embryo_implantation0.86685221
95MP0005310_abnormal_salivary_gland0.86572774
96MP0010307_abnormal_tumor_latency0.86464057
97* MP0000689_abnormal_spleen_morphology0.85987313
98MP0004782_abnormal_surfactant_physiolog0.85603115
99MP0001849_ear_inflammation0.85072028
100MP0000465_gastrointestinal_hemorrhage0.84651655
101MP0003634_abnormal_glial_cell0.84535229
102MP0009278_abnormal_bone_marrow0.83492014
103MP0000249_abnormal_blood_vessel0.82046398
104MP0001851_eye_inflammation0.80467725
105MP0002166_altered_tumor_susceptibility0.79053235
106MP0009333_abnormal_splenocyte_physiolog0.78827870
107MP0002933_joint_inflammation0.77771120
108MP0001764_abnormal_homeostasis0.76561279
109MP0003879_abnormal_hair_cell0.76058821
110MP0003632_abnormal_nervous_system0.75590212
111MP0005174_abnormal_tail_pigmentation0.75321906
112MP0004883_abnormal_blood_vessel0.73859701
113MP0005397_hematopoietic_system_phenotyp0.73548805
114MP0001545_abnormal_hematopoietic_system0.73548805
115MP0001881_abnormal_mammary_gland0.73390789
116MP0003183_abnormal_peptide_metabolism0.72874888
117MP0003795_abnormal_bone_structure0.72349392
118MP0008874_decreased_physiological_sensi0.71371077
119MP0001756_abnormal_urination0.71196521
120* MP0009642_abnormal_blood_homeostasis0.70726174
121* MP0002429_abnormal_blood_cell0.70605501
122MP0000920_abnormal_myelination0.69711984
123MP0002398_abnormal_bone_marrow0.67938296
124MP0005390_skeleton_phenotype0.64998035

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)5.41739457
2Increased cerebral lipofuscin (HP:0011813)5.26753896
3Recurrent abscess formation (HP:0002722)4.78502401
4Systemic lupus erythematosus (HP:0002725)4.69013698
5Eczematoid dermatitis (HP:0000976)4.55131153
6Increased neuronal autofluorescent lipopigment (HP:0002074)4.43834280
7Recurrent bacterial skin infections (HP:0005406)4.43009239
8Xanthomatosis (HP:0000991)4.20805343
9Axonal loss (HP:0003447)4.13177794
10Myocardial infarction (HP:0001658)3.97182498
11Complement deficiency (HP:0004431)3.97127979
12Joint hemorrhage (HP:0005261)3.94891784
13Dysostosis multiplex (HP:0000943)3.91576981
14Deep venous thrombosis (HP:0002625)3.88845564
15Mutism (HP:0002300)3.66680111
16* Vacuolated lymphocytes (HP:0001922)3.62980915
17Glomerulonephritis (HP:0000099)3.56404499
18Hyperlipoproteinemia (HP:0010980)3.51474787
19Mucopolysacchariduria (HP:0008155)3.47106736
20Urinary glycosaminoglycan excretion (HP:0003541)3.47106736
21Abnormality of liposaccharide metabolism (HP:0010968)3.46122238
22Abnormality of glycosphingolipid metabolism (HP:0004343)3.46122238
23Abnormality of glycolipid metabolism (HP:0010969)3.46122238
24Intrahepatic cholestasis (HP:0001406)3.45756154
25Abnormality of complement system (HP:0005339)3.38269026
26Neurofibrillary tangles (HP:0002185)3.37113158
27Abnormality of aromatic amino acid family metabolism (HP:0004338)3.33293030
28Disinhibition (HP:0000734)3.31790739
29Prolonged partial thromboplastin time (HP:0003645)3.26979154
30Abnormality of glycosaminoglycan metabolism (HP:0004371)3.26741207
31Abnormality of mucopolysaccharide metabolism (HP:0011020)3.26741207
32Abnormality of polysaccharide metabolism (HP:0011012)3.26741207
33* Abnormality of macrophages (HP:0004311)3.24172076
34Abnormality of monocarboxylic acid metabolism (HP:0010996)3.18966851
35Apathy (HP:0000741)3.09008655
36Autoimmune thrombocytopenia (HP:0001973)3.07412135
37Diminished motivation (HP:0000745)3.03241232
38Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.01234459
39Purpura (HP:0000979)2.99956806
40Loss of speech (HP:0002371)2.96627969
41Recurrent skin infections (HP:0001581)2.91064692
42Epidermoid cyst (HP:0200040)2.90258260
43Upper motor neuron abnormality (HP:0002127)2.89913226
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.86711735
45Gingivitis (HP:0000230)2.77702842
46Abnormality of the vasculature of the conjunctiva (HP:0008054)2.77083880
47Abnormality of the common coagulation pathway (HP:0010990)2.70724520
48Hypobetalipoproteinemia (HP:0003563)2.70277099
49Abnormality of the periventricular white matter (HP:0002518)2.69598492
50Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.69341254
51Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.61598383
52Nuclear cataract (HP:0100018)2.61439118
53Neuronal loss in central nervous system (HP:0002529)2.60455142
54Nephritis (HP:0000123)2.58857661
55Nausea (HP:0002018)2.58648551
56Conjunctival telangiectasia (HP:0000524)2.53036354
57* Hypercholesterolemia (HP:0003124)2.53005960
58Cerebral inclusion bodies (HP:0100314)2.49791097
59Gingival bleeding (HP:0000225)2.49012610
60Hypoalphalipoproteinemia (HP:0003233)2.47668226
61Peripheral demyelination (HP:0011096)2.42795645
62Hypolipoproteinemia (HP:0010981)2.41192944
63Mediastinal lymphadenopathy (HP:0100721)2.38917998
64Skin nodule (HP:0200036)2.36248043
65Pathologic fracture (HP:0002756)2.33809466
66Abnormality of the lumbar spine (HP:0100712)2.31379563
67Metaphyseal irregularity (HP:0003025)2.29822245
68Chronic mucocutaneous candidiasis (HP:0002728)2.29745446
69Recurrent cutaneous fungal infections (HP:0011370)2.29745446
70Inappropriate behavior (HP:0000719)2.29405595
71Myositis (HP:0100614)2.27956926
72Personality changes (HP:0000751)2.27828629
73Urticaria (HP:0001025)2.26178196
74Obstructive lung disease (HP:0006536)2.24951424
75Chronic obstructive pulmonary disease (HP:0006510)2.24951424
76Amyloidosis (HP:0011034)2.24359973
77Cardiomegaly (HP:0001640)2.22670459
78Hyperammonemia (HP:0001987)2.21391158
79Progressive neurologic deterioration (HP:0002344)2.20323298
80Periodontitis (HP:0000704)2.19283286
81Agnosia (HP:0010524)2.17291409
82Abnormality of sulfur amino acid metabolism (HP:0004339)2.16991906
83Dementia (HP:0000726)2.16866167
84Thoracic kyphosis (HP:0002942)2.16562702
85Hematochezia (HP:0002573)2.13765788
86Recurrent fungal infections (HP:0002841)2.13194269
87Mitral stenosis (HP:0001718)2.10527535
88Orchitis (HP:0100796)2.10016799
89Hydroxyprolinuria (HP:0003080)2.09694916
90Abnormality of proline metabolism (HP:0010907)2.09694916
91Elevated erythrocyte sedimentation rate (HP:0003565)2.08385733
92Abnormality of iron homeostasis (HP:0011031)2.07702916
93Global brain atrophy (HP:0002283)2.06969746
94Spontaneous hematomas (HP:0007420)2.06346009
95Pustule (HP:0200039)2.05525714
96Menorrhagia (HP:0000132)2.04748595
97Tetraparesis (HP:0002273)2.03078555
98Sensorimotor neuropathy (HP:0007141)2.02838200
99Basal ganglia calcification (HP:0002135)2.01665315
100Abnormality of the intrinsic pathway (HP:0010989)2.01181931
101Hepatocellular carcinoma (HP:0001402)1.99786333
102Increased serum ferritin (HP:0003281)1.99071920
103Petechiae (HP:0000967)1.98735750
104Abnormality of purine metabolism (HP:0004352)1.98455129
105Poor head control (HP:0002421)1.97410217
106Retinal atrophy (HP:0001105)1.96661138
107Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96657787
108Conjugated hyperbilirubinemia (HP:0002908)1.95709783
109* Hepatosplenomegaly (HP:0001433)1.95602351
110Abnormality of fatty-acid metabolism (HP:0004359)1.93533786
111Increased CSF protein (HP:0002922)1.93029126
112Ketosis (HP:0001946)1.92436619
113Abnormality of nucleobase metabolism (HP:0010932)1.90992608
114Mucosal telangiectasiae (HP:0100579)1.90876611
115J-shaped sella turcica (HP:0002680)1.88825987
116Asymmetric septal hypertrophy (HP:0001670)1.86081036
117Progressive visual loss (HP:0000529)1.85792380
118Bone pain (HP:0002653)1.85612619
119Abnormality of transition element cation homeostasis (HP:0011030)1.85447936
120Pulmonary embolism (HP:0002204)1.85378555
121Abnormality of methionine metabolism (HP:0010901)1.84840071
122Pulmonary infiltrates (HP:0002113)1.84699459
123Prostate neoplasm (HP:0100787)1.82890235
124T lymphocytopenia (HP:0005403)1.82289044
125Polygenic inheritance (HP:0010982)1.80954136
126Segmental peripheral demyelination/remyelination (HP:0003481)1.77635432
127Vertebral compression fractures (HP:0002953)1.77277208
128Polyneuropathy (HP:0001271)1.74197271
129Meningitis (HP:0001287)1.74079890
130Multiple enchondromatosis (HP:0005701)1.73866211
131Osteolytic defects of the hand bones (HP:0009699)1.73591731
132Osteolytic defects of the phalanges of the hand (HP:0009771)1.73591731
133Hemoptysis (HP:0002105)1.73445639
134Premature loss of primary teeth (HP:0006323)1.71101235
135Ovoid vertebral bodies (HP:0003300)1.70924838
136Prolonged neonatal jaundice (HP:0006579)1.70168763
137Abnormality of the prostate (HP:0008775)1.68920348
138Spondylolisthesis (HP:0003302)1.67905502
139Albinism (HP:0001022)1.67753598
140Amaurosis fugax (HP:0100576)1.66029477
141Thin bony cortex (HP:0002753)1.65142475
142Retrobulbar optic neuritis (HP:0100654)1.65061485
143Optic neuritis (HP:0100653)1.65061485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.51729796
2TBK13.25004416
3KIT3.02981098
4RIPK42.87235463
5TYK22.83978662
6MAP3K142.75340209
7PBK2.67610761
8BLK2.65110507
9NEK92.34328941
10MAP4K12.23144396
11TGFBR22.21441583
12IRAK42.19214017
13ACVR1B2.16716836
14IRAK32.11568931
15TRIB32.11070922
16PRPF4B2.04891582
17TAOK32.02128265
18FGFR41.99444755
19PKN21.95901973
20NME21.93490548
21JAK11.82521593
22IKBKE1.70902538
23PDK21.67866887
24CSF1R1.66383475
25CDC42BPA1.62624871
26JAK31.57065286
27DDR21.55826935
28BCKDK1.54462461
29IKBKB1.52331697
30SIK11.52128379
31ZAP701.50908886
32ABL21.50679710
33CSK1.50306528
34EPHB11.48746790
35CAMK1D1.47554923
36LIMK11.45163070
37RIPK11.44369579
38MAP2K31.43901325
39JAK21.37757632
40MST1R1.26284753
41HCK1.25572882
42SYK1.23247043
43ADRBK21.20832063
44PTK61.20629970
45PIM21.20317776
46MAP3K131.14082777
47TESK21.06675168
48LYN1.05799818
49RPS6KA21.05290959
50BTK1.05222517
51STK101.04155105
52TTN1.00300025
53TXK0.99381961
54LCK0.98308920
55BMX0.97224644
56BMPR20.97151697
57MAP3K30.96092797
58LRRK20.95566735
59ARAF0.94912550
60ITK0.93383411
61KDR0.93232810
62ERBB40.90302782
63SCYL20.88254828
64FGR0.87686183
65FES0.87146923
66GRK60.86330438
67TRPM70.85376022
68FLT30.84579178
69FGFR30.83429488
70MAP3K110.83023387
71TEC0.82734157
72EGFR0.81379539
73CDK60.80101960
74TESK10.77181745
75PIK3CG0.77123493
76MATK0.75685197
77CAMK1G0.74680496
78CHUK0.73896375
79ABL10.73090335
80RPS6KA40.69799330
81PRKCD0.68968236
82MAP3K20.68792768
83PIM10.65064088
84PRKG20.64855182
85RPS6KC10.63592570
86RPS6KL10.63592570
87PDPK10.61323057
88SGK30.60803315
89STK40.57873980
90YES10.57682930
91MAPK120.57316269
92MAP3K80.57020518
93EPHA30.55085284
94TAOK10.54890392
95MARK30.53948611
96IRAK20.53655874
97IGF1R0.53257553
98PRKCQ0.52722372
99MAPK110.51191516
100MAPK70.50836866
101PRKCH0.50330978
102PDK10.50258976
103STK30.48554361
104GSK3A0.48085429
105MAP3K50.46668129
106DAPK20.46165079
107RPS6KA60.45596080
108MOS0.45574212
109PDGFRB0.44633217
110PDGFRA0.44391752
111PAK40.44110640
112CAMKK10.43547255
113FYN0.43519712
114GRK70.43359453
115MAPKAPK20.42510131
116MAP3K10.42404465
117CAMKK20.40485848
118DYRK1B0.40308899
119MAP3K60.39052820
120MAP3K100.38736903
121FER0.37603097
122MAPK40.37535536
123KSR10.33453233
124CLK10.31020125
125SRC0.28854005
126TAOK20.28837188
127KSR20.28139803
128DAPK30.27218475
129PRKACG0.26373073

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.73415771
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.20203170
3Complement and coagulation cascades_Homo sapiens_hsa046102.94057278
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.75141803
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.56434660
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.50687197
7* Lysosome_Homo sapiens_hsa041422.45456026
8Nitrogen metabolism_Homo sapiens_hsa009102.43514267
9Caffeine metabolism_Homo sapiens_hsa002322.26492997
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.18040775
11Arginine biosynthesis_Homo sapiens_hsa002201.96934833
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.92216447
13Autoimmune thyroid disease_Homo sapiens_hsa053201.92174463
14Fatty acid degradation_Homo sapiens_hsa000711.82506788
15Leishmaniasis_Homo sapiens_hsa051401.80224155
16PPAR signaling pathway_Homo sapiens_hsa033201.79974433
17Other glycan degradation_Homo sapiens_hsa005111.77692225
18Tryptophan metabolism_Homo sapiens_hsa003801.72994313
19Histidine metabolism_Homo sapiens_hsa003401.59979229
20Peroxisome_Homo sapiens_hsa041461.58878693
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51469550
22Phagosome_Homo sapiens_hsa041451.49022265
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48656259
24Type I diabetes mellitus_Homo sapiens_hsa049401.46393809
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.43881756
26Osteoclast differentiation_Homo sapiens_hsa043801.40473639
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36167695
28Tuberculosis_Homo sapiens_hsa051521.35566679
29Pertussis_Homo sapiens_hsa051331.32366067
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.31397142
31Fatty acid metabolism_Homo sapiens_hsa012121.30317262
32Viral myocarditis_Homo sapiens_hsa054161.29179253
33Malaria_Homo sapiens_hsa051441.28454655
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28215221
35Chemical carcinogenesis_Homo sapiens_hsa052041.25774656
36beta-Alanine metabolism_Homo sapiens_hsa004101.25626056
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21185920
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21098715
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20968632
40Legionellosis_Homo sapiens_hsa051341.19542833
41Starch and sucrose metabolism_Homo sapiens_hsa005001.18657231
42Rheumatoid arthritis_Homo sapiens_hsa053231.16011517
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.14366463
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13103785
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07687822
46Retinol metabolism_Homo sapiens_hsa008301.06669459
47Chemokine signaling pathway_Homo sapiens_hsa040621.06426556
48Vibrio cholerae infection_Homo sapiens_hsa051101.03901579
49Propanoate metabolism_Homo sapiens_hsa006401.01967594
50Bile secretion_Homo sapiens_hsa049760.99285018
51Butanoate metabolism_Homo sapiens_hsa006500.98244376
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.98101178
53ABC transporters_Homo sapiens_hsa020100.94599318
54Sphingolipid metabolism_Homo sapiens_hsa006000.92791604
55Phenylalanine metabolism_Homo sapiens_hsa003600.88225009
56* Steroid biosynthesis_Homo sapiens_hsa001000.87927398
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81245280
58Selenocompound metabolism_Homo sapiens_hsa004500.80356713
59Antigen processing and presentation_Homo sapiens_hsa046120.78365652
60Graft-versus-host disease_Homo sapiens_hsa053320.77297755
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.77105405
62Measles_Homo sapiens_hsa051620.77066777
63B cell receptor signaling pathway_Homo sapiens_hsa046620.75787600
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74232764
65Fat digestion and absorption_Homo sapiens_hsa049750.73710073
66Fatty acid elongation_Homo sapiens_hsa000620.73538323
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73298986
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70712215
69Vitamin digestion and absorption_Homo sapiens_hsa049770.70182083
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67183324
71Salmonella infection_Homo sapiens_hsa051320.66807895
72Collecting duct acid secretion_Homo sapiens_hsa049660.66323788
73Folate biosynthesis_Homo sapiens_hsa007900.65866996
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64915767
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64733605
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64584294
77Platelet activation_Homo sapiens_hsa046110.64131495
78Apoptosis_Homo sapiens_hsa042100.62308397
79Carbon metabolism_Homo sapiens_hsa012000.61687123
80Influenza A_Homo sapiens_hsa051640.61672064
81Toxoplasmosis_Homo sapiens_hsa051450.61215148
82Fructose and mannose metabolism_Homo sapiens_hsa000510.61213112
83Tyrosine metabolism_Homo sapiens_hsa003500.61034729
84Glycerolipid metabolism_Homo sapiens_hsa005610.60982237
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60390464
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60324960
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59609433
88Prion diseases_Homo sapiens_hsa050200.57297184
89Pentose phosphate pathway_Homo sapiens_hsa000300.56669730
90Acute myeloid leukemia_Homo sapiens_hsa052210.55775030
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.55471097
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55324355
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54142606
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.53287452
95Mineral absorption_Homo sapiens_hsa049780.53069006
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52919188
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52707583
98TNF signaling pathway_Homo sapiens_hsa046680.52234169
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52119558
100Galactose metabolism_Homo sapiens_hsa000520.52066912
101Pyruvate metabolism_Homo sapiens_hsa006200.51480409
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.50744925
103Sulfur metabolism_Homo sapiens_hsa009200.50632029
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49565905
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.49484902
106Hepatitis C_Homo sapiens_hsa051600.48206443
107Asthma_Homo sapiens_hsa053100.47674282
108Herpes simplex infection_Homo sapiens_hsa051680.47601815
109Renin-angiotensin system_Homo sapiens_hsa046140.47306877
110Amoebiasis_Homo sapiens_hsa051460.46364683
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45881271
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45667495
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45376346
114Hematopoietic cell lineage_Homo sapiens_hsa046400.45241424
115Allograft rejection_Homo sapiens_hsa053300.45064658
116Arginine and proline metabolism_Homo sapiens_hsa003300.43985932
117Shigellosis_Homo sapiens_hsa051310.43752456
118Endocytosis_Homo sapiens_hsa041440.42774041
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42621406
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42618278
121Glutathione metabolism_Homo sapiens_hsa004800.41343824
122Hepatitis B_Homo sapiens_hsa051610.40164553
123Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39426364
124Lysine degradation_Homo sapiens_hsa003100.39018021
125HIF-1 signaling pathway_Homo sapiens_hsa040660.38347422
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37966146
127African trypanosomiasis_Homo sapiens_hsa051430.37105911
128T cell receptor signaling pathway_Homo sapiens_hsa046600.36637782
129Renal cell carcinoma_Homo sapiens_hsa052110.36309557
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.34965937
131Prolactin signaling pathway_Homo sapiens_hsa049170.33746276
132Arachidonic acid metabolism_Homo sapiens_hsa005900.28777086
133Ether lipid metabolism_Homo sapiens_hsa005650.28616513
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25443554
135Insulin resistance_Homo sapiens_hsa049310.24761503
136Bladder cancer_Homo sapiens_hsa052190.24015349
137VEGF signaling pathway_Homo sapiens_hsa043700.23708530
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.22419122
139Synaptic vesicle cycle_Homo sapiens_hsa047210.22259736
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20684202
141Type II diabetes mellitus_Homo sapiens_hsa049300.20613837
142GnRH signaling pathway_Homo sapiens_hsa049120.20271811
143Pancreatic cancer_Homo sapiens_hsa052120.20061307
144Epstein-Barr virus infection_Homo sapiens_hsa051690.20012142
145SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19307285

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