LIPC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.64397729
2L-phenylalanine catabolic process (GO:0006559)7.64397729
3L-phenylalanine metabolic process (GO:0006558)7.30254747
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.30254747
5exogenous drug catabolic process (GO:0042738)6.96761897
6aromatic amino acid family catabolic process (GO:0009074)6.87428538
7indole-containing compound catabolic process (GO:0042436)6.18755826
8indolalkylamine catabolic process (GO:0046218)6.18755826
9tryptophan catabolic process (GO:0006569)6.18755826
10kynurenine metabolic process (GO:0070189)6.08204030
11bile acid biosynthetic process (GO:0006699)6.01452441
12* triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.00765257
13glyoxylate metabolic process (GO:0046487)5.85677778
14tryptophan metabolic process (GO:0006568)5.82908644
15negative regulation of fibrinolysis (GO:0051918)5.76519499
16urea metabolic process (GO:0019627)5.70756340
17urea cycle (GO:0000050)5.70756340
18epoxygenase P450 pathway (GO:0019373)5.69277823
19omega-hydroxylase P450 pathway (GO:0097267)5.68286115
20alpha-linolenic acid metabolic process (GO:0036109)5.63021150
21regulation of fibrinolysis (GO:0051917)5.55123644
22protein carboxylation (GO:0018214)5.45390418
23peptidyl-glutamic acid carboxylation (GO:0017187)5.45390418
24sulfur amino acid catabolic process (GO:0000098)5.44455832
25cysteine metabolic process (GO:0006534)5.42661798
26* high-density lipoprotein particle remodeling (GO:0034375)5.37789741
27complement activation, alternative pathway (GO:0006957)5.34891010
28regulation of protein activation cascade (GO:2000257)5.34521257
29nitrogen cycle metabolic process (GO:0071941)5.24459875
30serine family amino acid catabolic process (GO:0009071)5.18465532
31bile acid metabolic process (GO:0008206)5.15353025
32regulation of cholesterol esterification (GO:0010872)5.00862903
33aromatic amino acid family metabolic process (GO:0009072)4.99232917
34regulation of complement activation (GO:0030449)4.97521801
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.91110961
36regulation of triglyceride catabolic process (GO:0010896)4.90089007
37tyrosine metabolic process (GO:0006570)4.85649244
38homocysteine metabolic process (GO:0050667)4.76878829
39phospholipid efflux (GO:0033700)4.69518446
40negative regulation of sterol transport (GO:0032372)4.69160726
41negative regulation of cholesterol transport (GO:0032375)4.69160726
42alpha-amino acid catabolic process (GO:1901606)4.68348984
43* reverse cholesterol transport (GO:0043691)4.64453292
44* plasma lipoprotein particle remodeling (GO:0034369)4.64316413
45* protein-lipid complex remodeling (GO:0034368)4.64316413
46* macromolecular complex remodeling (GO:0034367)4.64316413
47amino-acid betaine metabolic process (GO:0006577)4.62317961
48lysine catabolic process (GO:0006554)4.60062766
49lysine metabolic process (GO:0006553)4.60062766
50cellular ketone body metabolic process (GO:0046950)4.56660226
51glycine metabolic process (GO:0006544)4.52236386
52* acylglycerol homeostasis (GO:0055090)4.46951291
53* triglyceride homeostasis (GO:0070328)4.46951291
54bile acid and bile salt transport (GO:0015721)4.45637258
55* low-density lipoprotein particle remodeling (GO:0034374)4.44335943
56imidazole-containing compound metabolic process (GO:0052803)4.41020781
57indolalkylamine metabolic process (GO:0006586)4.38572609
58coenzyme catabolic process (GO:0009109)4.36064764
59cholesterol efflux (GO:0033344)4.32793274
60cellular amino acid catabolic process (GO:0009063)4.31081226
61intestinal cholesterol absorption (GO:0030299)4.30202937
62cellular glucuronidation (GO:0052695)4.29796954
63cellular biogenic amine catabolic process (GO:0042402)4.29227362
64amine catabolic process (GO:0009310)4.29227362
65glutamate metabolic process (GO:0006536)4.26721014
66serine family amino acid metabolic process (GO:0009069)4.23718783
67drug metabolic process (GO:0017144)4.23571230
68* plasma lipoprotein particle clearance (GO:0034381)4.20476625
69negative regulation of hemostasis (GO:1900047)4.19620543
70negative regulation of blood coagulation (GO:0030195)4.19620543
71positive regulation of hemostasis (GO:1900048)4.19121726
72positive regulation of blood coagulation (GO:0030194)4.19121726
73ethanol oxidation (GO:0006069)4.15265942
74benzene-containing compound metabolic process (GO:0042537)4.15081548
75positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.11281408
76serine family amino acid biosynthetic process (GO:0009070)4.11124372
77plasma lipoprotein particle assembly (GO:0034377)4.10927789
78aldehyde catabolic process (GO:0046185)4.10912913
79dicarboxylic acid biosynthetic process (GO:0043650)4.08553410
80cellular modified amino acid catabolic process (GO:0042219)4.08124802
81fibrinolysis (GO:0042730)4.07498292
82arginine metabolic process (GO:0006525)4.06705497
83oxidative demethylation (GO:0070989)4.06155963
84negative regulation of protein activation cascade (GO:2000258)3.96281385
85ketone body metabolic process (GO:1902224)3.95348233
86blood coagulation, intrinsic pathway (GO:0007597)3.94284802
87drug catabolic process (GO:0042737)3.93174137
88complement activation, classical pathway (GO:0006958)3.89554654
89positive regulation of lipoprotein lipase activity (GO:0051006)3.86248514
90positive regulation of triglyceride lipase activity (GO:0061365)3.86248514
91negative regulation of coagulation (GO:0050819)3.86094095
92complement activation (GO:0006956)3.84061920
93cofactor catabolic process (GO:0051187)3.82308058
94very-low-density lipoprotein particle assembly (GO:0034379)3.81634459
95protein activation cascade (GO:0072376)3.81576930
96glucuronate metabolic process (GO:0019585)3.81008697
97uronic acid metabolic process (GO:0006063)3.81008697
98positive regulation of lipid catabolic process (GO:0050996)3.80759195
99regulation of plasminogen activation (GO:0010755)3.80073023
100negative regulation of lipase activity (GO:0060192)3.79304429
101positive regulation of coagulation (GO:0050820)3.78792349
102phospholipid homeostasis (GO:0055091)3.77574485
103organic acid catabolic process (GO:0016054)3.77262898
104carboxylic acid catabolic process (GO:0046395)3.77262898
105short-chain fatty acid metabolic process (GO:0046459)3.71179335
106regulation of bile acid biosynthetic process (GO:0070857)3.71095453
107protein-lipid complex assembly (GO:0065005)3.69257641
108S-adenosylmethionine metabolic process (GO:0046500)3.68365696
109* cholesterol homeostasis (GO:0042632)3.68338579
110acetyl-CoA metabolic process (GO:0006084)3.65605434
111negative regulation of wound healing (GO:0061045)3.65479535
112xenobiotic catabolic process (GO:0042178)3.63897998
113cytolysis (GO:0019835)3.63683709
114* sterol homeostasis (GO:0055092)3.62023031
115regulation of cholesterol homeostasis (GO:2000188)3.61386482
116NAD biosynthetic process (GO:0009435)3.58797559
117flavonoid metabolic process (GO:0009812)3.57950628
118nicotinamide nucleotide biosynthetic process (GO:0019359)3.55221896
119pyridine nucleotide biosynthetic process (GO:0019363)3.55221896
120peptidyl-glutamic acid modification (GO:0018200)3.54727566
121opsonization (GO:0008228)3.53248694
122phenylpropanoid metabolic process (GO:0009698)3.46341511
123regulation of humoral immune response (GO:0002920)3.44998512
124* plasma lipoprotein particle organization (GO:0071827)3.44662362
125regulation of lipoprotein metabolic process (GO:0050746)3.35568878
126ethanol metabolic process (GO:0006067)3.32546543
127disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.25689830
128killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.25689830
129arginine catabolic process (GO:0006527)3.24484929
130dopamine transport (GO:0015872)3.19381588
131acute-phase response (GO:0006953)3.19344246
132* protein-lipid complex subunit organization (GO:0071825)3.11184672
133thrombin receptor signaling pathway (GO:0070493)3.10620824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.46664718
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.24543960
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse7.07064291
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.52866536
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.28570323
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.17763800
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.85189099
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.05484152
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.97381688
10GBX2_23144817_ChIP-Seq_PC3_Human3.24508579
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.62038267
12VDR_22108803_ChIP-Seq_LS180_Human2.36948230
13ZNF274_21170338_ChIP-Seq_K562_Hela2.25399559
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19363763
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07864666
16* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03744864
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.03354908
18* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9888134
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96192938
20IGF1R_20145208_ChIP-Seq_DFB_Human1.93947009
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.92781934
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86399050
23* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.81460212
24ER_23166858_ChIP-Seq_MCF-7_Human1.77383628
25EZH2_22144423_ChIP-Seq_EOC_Human1.73141970
26* FOXA2_19822575_ChIP-Seq_HepG2_Human1.59041163
27HTT_18923047_ChIP-ChIP_STHdh_Human1.57517658
28IRF1_19129219_ChIP-ChIP_H3396_Human1.55078431
29CLOCK_20551151_ChIP-Seq_293T_Human1.53633279
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52722639
31GATA1_22025678_ChIP-Seq_K562_Human1.48308083
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.46836479
33* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46310672
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45056673
35* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44970740
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.42607236
37* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42321687
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.41433167
39STAT3_23295773_ChIP-Seq_U87_Human1.41411841
40* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40500215
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37919155
42TP53_16413492_ChIP-PET_HCT116_Human1.36942873
43* NANOG_19829295_ChIP-Seq_ESCs_Human1.36722421
44* SOX2_19829295_ChIP-Seq_ESCs_Human1.36722421
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35880332
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34128813
47P300_19829295_ChIP-Seq_ESCs_Human1.33943967
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32777550
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32329493
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30393501
51* AR_25329375_ChIP-Seq_VCAP_Human1.28446091
52* TCF4_23295773_ChIP-Seq_U87_Human1.26207441
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25867997
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.23557262
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.22873664
56TCF4_22108803_ChIP-Seq_LS180_Human1.20395330
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19908136
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19651155
59CRX_20693478_ChIP-Seq_RETINA_Mouse1.19501427
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19337110
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.19337110
62ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18143168
63* SMAD4_21799915_ChIP-Seq_A2780_Human1.17099440
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11047052
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10417286
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09752205
67EWS_26573619_Chip-Seq_HEK293_Human1.09508875
68OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09073206
69CBP_20019798_ChIP-Seq_JUKART_Human1.07676521
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07676521
71CDX2_22108803_ChIP-Seq_LS180_Human1.06774659
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06236876
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05346917
74P53_22387025_ChIP-Seq_ESCs_Mouse1.04117562
75* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03288300
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.03245363
77TCF4_18268006_ChIP-ChIP_LS174T_Human1.02813525
78IRF8_22096565_ChIP-ChIP_GC-B_Human1.01664712
79ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01371741
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99202469
81STAT3_18555785_Chip-Seq_ESCs_Mouse0.98813338
82TP53_22573176_ChIP-Seq_HFKS_Human0.96429614
83* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96264295
84OCT4_18555785_Chip-Seq_ESCs_Mouse0.96165894
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95136404
86KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95099459
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95032821
88* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94678257
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93754799
90NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93268113
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92064008
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92036895
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91392246
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91021868
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.90760600
96SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90537518
97FLI1_21867929_ChIP-Seq_TH2_Mouse0.90138196
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89359829
99* IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89120665
100* NANOG_20526341_ChIP-Seq_ESCs_Human0.88824315
101PHF8_20622853_ChIP-Seq_HELA_Human0.88694644
102E2F1_18555785_Chip-Seq_ESCs_Mouse0.88154641
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87897005
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85975227
105PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85867995
106RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80620874
107KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78703608
108ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78388299
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78364824
110* GATA4_25053715_ChIP-Seq_YYC3_Human0.77938466
111* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76750568
112RARA_24833708_ChIP-Seq_LIVER_Mouse0.76656172
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.76636909
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73506375
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72666005
116ZNF263_19887448_ChIP-Seq_K562_Human0.72007797
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69792982
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.68064369
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.66885584
120RARB_24833708_ChIP-Seq_LIVER_Mouse0.66437669
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.65303425
122AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65069804
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65050077
124E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.62271711
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62055760
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62055760
127RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61995022
128ESR2_21235772_ChIP-Seq_MCF-7_Human0.61825340
129BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61588322
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59998149
131CEBPB_22108803_ChIP-Seq_LS180_Human0.58804501
132EGR1_19032775_ChIP-ChIP_M12_Human0.55840117
133LXR_22292898_ChIP-Seq_THP-1_Human0.55209187
134STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52417027
135MYC_19915707_ChIP-ChIP_AK7_Human0.52314871
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.52076774
137AR_20517297_ChIP-Seq_VCAP_Human0.51935945
138PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51713649
139FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50047754
140ESET_19884257_ChIP-Seq_ESCs_Mouse0.49847984
141FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49826793
142STAT1_17558387_ChIP-Seq_HELA_Human0.47909730
143P53_21459846_ChIP-Seq_SAOS-2_Human0.47870343
144FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.46844183
145CBP_21632823_ChIP-Seq_H3396_Human0.46769432
146PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46209740
147PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45520286
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43526843
149* GATA1_19941827_ChIP-Seq_MEL_Mouse0.42475395
150TAF2_19829295_ChIP-Seq_ESCs_Human0.42388921
151CDX2_20551321_ChIP-Seq_CACO-2_Human0.42002657
152TAF15_26573619_Chip-Seq_HEK293_Human0.41352707
153SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40993760
154FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40589824
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.40014140
156ESR1_21235772_ChIP-Seq_MCF-7_Human0.39734290
157CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39192606
158* GATA1_19941826_ChIP-Seq_K562_Human0.39150632
159* GATA2_19941826_ChIP-Seq_K562_Human0.38626104
160GATA6_25053715_ChIP-Seq_YYC3_Human0.37976080
161PPAR_26484153_Chip-Seq_NCI-H1993_Human0.37593150
162STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37545355
163MYC_27129775_Chip-Seq_CORNEA_Mouse0.37529877
164ERG_21242973_ChIP-ChIP_JURKAT_Human0.37415505
165ESR1_20079471_ChIP-ChIP_T-47D_Human0.37347829
166LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36718235
167BCAT_22108803_ChIP-Seq_LS180_Human0.36564285
168SPI1_26923725_Chip-Seq_HPCs_Mouse0.36375549
169SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.35710506
170CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.35584409
171SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.34162782
172NCOR_22424771_ChIP-Seq_293T_Human0.34071546
173ERG_20517297_ChIP-Seq_VCAP_Human0.33630022
174BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.33330824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.35377886
2MP0005360_urolithiasis7.57415340
3MP0005085_abnormal_gallbladder_physiolo6.43145808
4MP0005365_abnormal_bile_salt6.16618604
5MP0008875_abnormal_xenobiotic_pharmacok5.11721018
6MP0003806_abnormal_nucleotide_metabolis4.36530038
7MP0003252_abnormal_bile_duct3.89654918
8* MP0010329_abnormal_lipoprotein_level3.50710442
9MP0009840_abnormal_foam_cell3.32763149
10MP0005083_abnormal_biliary_tract3.06426980
11MP0003195_calcinosis2.87466040
12MP0005332_abnormal_amino_acid2.74538568
13MP0001666_abnormal_nutrient_absorption2.59117976
14MP0003191_abnormal_cellular_cholesterol2.28545107
15MP0000609_abnormal_liver_physiology2.17990520
16MP0004019_abnormal_vitamin_homeostasis2.11700827
17* MP0002118_abnormal_lipid_homeostasis2.06865414
18MP0002138_abnormal_hepatobiliary_system1.95476016
19MP0003868_abnormal_feces_composition1.90359524
20MP0005319_abnormal_enzyme/_coenzyme1.83484029
21MP0001764_abnormal_homeostasis1.69369576
22MP0009697_abnormal_copulation1.67813497
23MP0005167_abnormal_blood-brain_barrier1.61294809
24MP0005584_abnormal_enzyme/coenzyme_acti1.59833338
25MP0005551_abnormal_eye_electrophysiolog1.49223084
26MP0005451_abnormal_body_composition1.47560263
27MP0003011_delayed_dark_adaptation1.38661684
28MP0003656_abnormal_erythrocyte_physiolo1.30592591
29MP0003186_abnormal_redox_activity1.27814906
30MP0009643_abnormal_urine_homeostasis1.23194229
31MP0005646_abnormal_pituitary_gland1.20763874
32MP0003879_abnormal_hair_cell1.19252064
33MP0000598_abnormal_liver_morphology1.18781324
34MP0005410_abnormal_fertilization1.18642788
35MP0005647_abnormal_sex_gland1.13619668
36MP0003705_abnormal_hypodermis_morpholog1.13608707
37MP0002736_abnormal_nociception_after1.11033141
38MP0000604_amyloidosis1.10228299
39MP0008004_abnormal_stomach_pH1.09955135
40MP0009764_decreased_sensitivity_to1.06845442
41MP0004142_abnormal_muscle_tone1.05698450
42MP0003122_maternal_imprinting1.05070457
43MP0002254_reproductive_system_inflammat1.03724128
44MP0008775_abnormal_heart_ventricle1.03486779
45MP0009763_increased_sensitivity_to1.03077167
46MP0006276_abnormal_autonomic_nervous1.00590883
47MP0005379_endocrine/exocrine_gland_phen0.99471387
48MP0010368_abnormal_lymphatic_system0.97007124
49MP0004043_abnormal_pH_regulation0.94376393
50MP0001986_abnormal_taste_sensitivity0.93450415
51MP0005636_abnormal_mineral_homeostasis0.91943411
52MP0001968_abnormal_touch/_nociception0.91793097
53MP0008469_abnormal_protein_level0.90534621
54MP0003646_muscle_fatigue0.89893985
55MP0005187_abnormal_penis_morphology0.89726629
56* MP0009642_abnormal_blood_homeostasis0.86497800
57MP0009780_abnormal_chondrocyte_physiolo0.85646727
58MP0005408_hypopigmentation0.85531495
59MP0002163_abnormal_gland_morphology0.84996428
60MP0006036_abnormal_mitochondrial_physio0.83976229
61MP0005376_homeostasis/metabolism_phenot0.80902526
62MP0001984_abnormal_olfaction0.80193327
63MP0010386_abnormal_urinary_bladder0.78752626
64MP0009765_abnormal_xenobiotic_induced0.78368203
65MP0002078_abnormal_glucose_homeostasis0.77808006
66MP0002876_abnormal_thyroid_physiology0.77730138
67MP0005084_abnormal_gallbladder_morpholo0.76135113
68MP0004133_heterotaxia0.73790244
69MP0005670_abnormal_white_adipose0.71073022
70MP0005220_abnormal_exocrine_pancreas0.70992893
71MP0008877_abnormal_DNA_methylation0.70987152
72MP0002971_abnormal_brown_adipose0.70118326
73MP0003136_yellow_coat_color0.67702795
74MP0005334_abnormal_fat_pad0.67449030
75MP0001661_extended_life_span0.67368593
76MP0003690_abnormal_glial_cell0.66866322
77MP0004130_abnormal_muscle_cell0.66172733
78MP0005266_abnormal_metabolism0.65873148
79MP0009053_abnormal_anal_canal0.65514103
80MP0005535_abnormal_body_temperature0.65425988
81MP0003183_abnormal_peptide_metabolism0.64788832
82MP0000639_abnormal_adrenal_gland0.62684863
83MP0003329_amyloid_beta_deposits0.62453884
84MP0005645_abnormal_hypothalamus_physiol0.61154657
85MP0009745_abnormal_behavioral_response0.59815962
86MP0001663_abnormal_digestive_system0.57357828
87MP0001756_abnormal_urination0.57096505
88MP0002089_abnormal_postnatal_growth/wei0.56778433
89MP0006035_abnormal_mitochondrial_morpho0.56262343
90MP0005464_abnormal_platelet_physiology0.56206719
91MP0009046_muscle_twitch0.55821439
92MP0005448_abnormal_energy_balance0.54733189
93MP0002272_abnormal_nervous_system0.50316760
94MP0002822_catalepsy0.49035622
95MP0005395_other_phenotype0.48427273
96MP0001485_abnormal_pinna_reflex0.46890628
97MP0008874_decreased_physiological_sensi0.46389661
98MP0003638_abnormal_response/metabolism_0.46243474
99MP0002136_abnormal_kidney_physiology0.45997670
100MP0003718_maternal_effect0.45926716
101MP0003436_decreased_susceptibility_to0.45914395
102MP0008873_increased_physiological_sensi0.45026885
103MP0001324_abnormal_eye_pigmentation0.44589225
104MP0002928_abnormal_bile_duct0.43854010
105MP0004782_abnormal_surfactant_physiolog0.42526483
106MP0003075_altered_response_to0.41363205
107MP0002837_dystrophic_cardiac_calcinosis0.40904095
108MP0003724_increased_susceptibility_to0.39576856
109MP0005166_decreased_susceptibility_to0.38390151
110MP0008872_abnormal_physiological_respon0.38177999
111* MP0003953_abnormal_hormone_level0.37876264
112MP0005248_abnormal_Harderian_gland0.37593148
113MP0009672_abnormal_birth_weight0.37412588
114MP0004381_abnormal_hair_follicle0.37055138
115MP0006082_CNS_inflammation0.36738906
116MP0005666_abnormal_adipose_tissue0.34334742
117MP0001853_heart_inflammation0.34244913
118MP0000249_abnormal_blood_vessel0.34197499
119MP0001243_abnormal_dermal_layer0.33038127
120MP0004883_abnormal_blood_vessel0.33025701
121MP0009115_abnormal_fat_cell0.32774687
122MP0001845_abnormal_inflammatory_respons0.31297703
123MP0002796_impaired_skin_barrier0.30919555
124MP0002168_other_aberrant_phenotype0.30871503
125MP0000230_abnormal_systemic_arterial0.29764344
126MP0000579_abnormal_nail_morphology0.29190254
127MP0002970_abnormal_white_adipose0.29150822
128MP0002132_abnormal_respiratory_system0.25637078
129MP0001881_abnormal_mammary_gland0.25605330
130MP0005164_abnormal_response_to0.25217964
131MP0009384_cardiac_valve_regurgitation0.25190623
132MP0002090_abnormal_vision0.22545942
133MP0005058_abnormal_lysosome_morphology0.22394686

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.55682789
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.43333683
3Intrahepatic cholestasis (HP:0001406)7.36511793
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.67580257
5Prolonged partial thromboplastin time (HP:0003645)6.65749337
6Hypobetalipoproteinemia (HP:0003563)6.53191964
7* Xanthomatosis (HP:0000991)5.87602985
8Hyperlipoproteinemia (HP:0010980)5.62010501
9Complement deficiency (HP:0004431)5.30248230
10Joint hemorrhage (HP:0005261)4.90152446
11Hypolipoproteinemia (HP:0010981)4.86120905
12Hyperammonemia (HP:0001987)4.63904062
13Prolonged bleeding time (HP:0003010)4.51608768
14Abnormality of the common coagulation pathway (HP:0010990)4.50443371
15Epidermoid cyst (HP:0200040)4.48944129
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.44165022
17Hyperglycinemia (HP:0002154)4.43805040
18Purpura (HP:0000979)4.36324918
19Abnormality of methionine metabolism (HP:0010901)4.28134721
20Ketosis (HP:0001946)4.24557166
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.23774147
22Hypoalphalipoproteinemia (HP:0003233)4.21932429
23Fat malabsorption (HP:0002630)4.15508372
24Abnormality of glutamine family amino acid metabolism (HP:0010902)4.10279237
25Abnormality of aspartate family amino acid metabolism (HP:0010899)4.10083328
26Increased mean platelet volume (HP:0011877)3.92577672
27Hyperglycinuria (HP:0003108)3.92127349
28Abnormality of glycine metabolism (HP:0010895)3.91929535
29Abnormality of serine family amino acid metabolism (HP:0010894)3.91929535
30Abnormality of complement system (HP:0005339)3.86827200
31Hypoglycemic coma (HP:0001325)3.86782517
32Abnormality of pyrimidine metabolism (HP:0004353)3.85640932
33Abnormality of the intrinsic pathway (HP:0010989)3.81944130
34Conjugated hyperbilirubinemia (HP:0002908)3.71025724
35Hypercholesterolemia (HP:0003124)3.65832685
36Epistaxis (HP:0000421)3.57759132
37Abnormal platelet volume (HP:0011876)3.54748753
38Hyperbilirubinemia (HP:0002904)3.38043768
39Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36749543
40Abnormality of fatty-acid metabolism (HP:0004359)3.33935045
41Steatorrhea (HP:0002570)3.12937829
42Delayed CNS myelination (HP:0002188)3.11755143
43Abnormality of serum amino acid levels (HP:0003112)3.07432233
44Hypochromic microcytic anemia (HP:0004840)3.05381993
45Abnormality of nucleobase metabolism (HP:0010932)3.04233695
46Hepatocellular carcinoma (HP:0001402)3.01820005
47Spontaneous abortion (HP:0005268)3.01619198
48Ketoacidosis (HP:0001993)3.00917357
49Myocardial infarction (HP:0001658)2.97563045
50Petechiae (HP:0000967)2.83688699
51Metabolic acidosis (HP:0001942)2.77583223
52Skin nodule (HP:0200036)2.76698049
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.71218878
54Abnormality of alanine metabolism (HP:0010916)2.71218878
55Hyperalaninemia (HP:0003348)2.71218878
56Systemic lupus erythematosus (HP:0002725)2.68361170
57Vascular calcification (HP:0004934)2.63966569
58Abnormality of purine metabolism (HP:0004352)2.63530076
59Acanthocytosis (HP:0001927)2.62155510
60Lethargy (HP:0001254)2.60492008
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59126874
62Dicarboxylic aciduria (HP:0003215)2.59126874
63Fair hair (HP:0002286)2.53289614
64Abnormality of urine glucose concentration (HP:0011016)2.50460983
65Glycosuria (HP:0003076)2.50460983
66Abnormal gallbladder morphology (HP:0012437)2.49734102
67Glomerulonephritis (HP:0000099)2.49227876
68Impaired platelet aggregation (HP:0003540)2.48346454
69Abnormal platelet function (HP:0011869)2.48346454
70Joint swelling (HP:0001386)2.47766930
71Hypoglycemic seizures (HP:0002173)2.46644690
72Mitral stenosis (HP:0001718)2.46431517
73Spastic diplegia (HP:0001264)2.45930950
74Arthropathy (HP:0003040)2.44783528
75Cholelithiasis (HP:0001081)2.43691886
76Cerebral edema (HP:0002181)2.41895328
77Gout (HP:0001997)2.38151306
78Recurrent gram-negative bacterial infections (HP:0005420)2.36118660
79Irritability (HP:0000737)2.34457407
80Neonatal onset (HP:0003623)2.34007421
81Cardiovascular calcification (HP:0011915)2.33894679
82Abnormal gallbladder physiology (HP:0012438)2.32880956
83Cholecystitis (HP:0001082)2.32880956
84Malnutrition (HP:0004395)2.30319782
85Amyloidosis (HP:0011034)2.29334925
86Decreased central vision (HP:0007663)2.29092353
87Gingival bleeding (HP:0000225)2.25791084
88Esophageal varix (HP:0002040)2.19705620
89Menorrhagia (HP:0000132)2.19397781
90Pancreatitis (HP:0001733)2.14959992
91Sensorimotor neuropathy (HP:0007141)2.13685698
92Thrombophlebitis (HP:0004418)2.10670573
93Late onset (HP:0003584)2.10607676
94Brushfield spots (HP:0001088)2.09936796
95Enlarged kidneys (HP:0000105)2.08530183
96Poikilocytosis (HP:0004447)2.08466125
97Optic neuritis (HP:0100653)2.07917865
98Retrobulbar optic neuritis (HP:0100654)2.07917865
99Pulmonary embolism (HP:0002204)2.07336282
100Vomiting (HP:0002013)2.06523899
101Opisthotonus (HP:0002179)2.04311485
102Abnormality of the renal cortex (HP:0011035)2.03744575
103Pancreatic islet-cell hyperplasia (HP:0004510)2.03364994
104Abnormal biliary tract physiology (HP:0012439)2.02836941
105Bile duct proliferation (HP:0001408)2.02836941
106Generalized aminoaciduria (HP:0002909)2.02661868
107Abnormality of the gallbladder (HP:0005264)2.01314629
108Hemorrhage of the eye (HP:0011885)2.00950550
109Hyperinsulinemic hypoglycemia (HP:0000825)1.99671380
110Hypothermia (HP:0002045)1.97257475
111Rickets (HP:0002748)1.95069712
112Osteomalacia (HP:0002749)1.92845801
113Abnormality of iron homeostasis (HP:0011031)1.91441095
114Abnormal pupillary function (HP:0007686)1.89989323
115Abnormal cartilage morphology (HP:0002763)1.89642012
116Hypophosphatemic rickets (HP:0004912)1.89056889
117Abnormality of transition element cation homeostasis (HP:0011030)1.88688381
118Facial shape deformation (HP:0011334)1.87799980
119Potter facies (HP:0002009)1.87799980
120Chronic hepatic failure (HP:0100626)1.84387446
121Elevated hepatic transaminases (HP:0002910)1.83637919
122Thyroid-stimulating hormone excess (HP:0002925)1.83634762
123Renal cortical cysts (HP:0000803)1.82842329
124Hydroxyprolinuria (HP:0003080)1.82825463
125Abnormality of proline metabolism (HP:0010907)1.82825463
126Abnormal enzyme/coenzyme activity (HP:0012379)1.82245009
127Abolished electroretinogram (ERG) (HP:0000550)1.81092568
128Abnormal urine output (HP:0012590)1.79872748
129Status epilepticus (HP:0002133)1.78552683
130Alkalosis (HP:0001948)1.77877770
131Nephritis (HP:0000123)1.75899903
132Pancreatic cysts (HP:0001737)1.74387588
133Abnormality of vitamin metabolism (HP:0100508)1.73538979
134Reticulocytosis (HP:0001923)1.72891706
135Congenital stationary night blindness (HP:0007642)1.72229243
136Keratoconjunctivitis (HP:0001096)1.71020968
137Hyperphosphaturia (HP:0003109)1.70861067
138Generalized hypopigmentation of hair (HP:0011358)1.70457449
139Gangrene (HP:0100758)1.66627412
140Orchitis (HP:0100796)1.66467802
141Hyperventilation (HP:0002883)1.65464282

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.30876839
2SIK14.63866873
3FGFR44.58073096
4ERN14.39619699
5TLK13.14648488
6TAOK33.07930232
7ADRBK22.93771107
8INSRR2.82091819
9WNK42.70655783
10MST42.70567234
11ERBB42.65738907
12ZAK2.41861346
13PKN22.34322906
14MAP2K42.24212474
15MAP4K22.20675938
16WNK32.10975724
17ACVR1B2.10872636
18MST1R2.05985769
19FLT31.96835229
20PIK3CG1.92862099
21TRIB31.84737955
22MAPK111.84189026
23CAMKK21.83876208
24TYK21.82320801
25STK391.73673856
26DAPK21.71916704
27MAPKAPK31.71883481
28BRSK21.68947978
29BMPR1B1.67700709
30LMTK21.63923463
31NUAK11.52776003
32LATS11.48937159
33ABL21.46301075
34PTK61.44469837
35TXK1.41687869
36TNIK1.38226256
37KDR1.36867662
38NEK91.36423524
39FRK1.35396168
40FGFR21.35289167
41NTRK31.31736415
42EIF2AK11.25012757
43PTK2B1.21830794
44GRK61.21071229
45JAK21.20389524
46TEC1.18902129
47MYLK1.18797589
48MAP2K31.18334439
49TBK11.16572747
50BMX1.14590120
51MAP3K71.14430395
52NLK1.13701239
53MAP3K101.12364753
54MAP3K141.09615265
55PRKAA21.05723723
56PAK31.05199293
57CASK1.04633914
58STK161.04569648
59JAK11.03822238
60PINK11.02944792
61MAPK131.01856430
62SIK21.01343842
63MAPK40.97116660
64STK30.95302047
65PLK20.95081385
66PRKCZ0.92934047
67PIK3CA0.92805726
68ADRBK10.92284324
69ERBB20.91501149
70FER0.91256683
71MAP3K30.90377168
72SYK0.86288207
73MAP3K110.85609728
74BTK0.84057431
75STK240.83947286
76FGR0.83587672
77IKBKB0.83321991
78TRIM280.82496178
79MAPK120.81181994
80CDK60.80752765
81MET0.80198773
82MAPK150.79667835
83PRKCE0.79566063
84MAP3K40.79555805
85CSF1R0.78652207
86TIE10.76303621
87EPHB10.76256644
88CSK0.75908771
89GRK50.75162912
90PRKACG0.73932730
91STK38L0.72556533
92OXSR10.72198940
93TNK20.71080683
94DYRK20.70898325
95DYRK1B0.69528283
96EPHA30.67776300
97IRAK30.65741945
98MAP2K60.64975680
99CAMK2G0.64405213
100CAMK1D0.63487601
101GSK3A0.63255643
102TGFBR20.62486446
103PRKAA10.62302175
104PRKG10.61742442
105RIPK10.61685132
106IKBKE0.61171510
107PRKCQ0.60965721
108MAPK70.59595191
109SGK30.57303825
110TAOK20.56305838
111FGFR30.55970709
112PRKACA0.55830991
113MAP3K130.54367571
114CSNK1G10.53733998
115GRK10.53658167
116MAP4K10.51278350
117PTK20.50646719
118MAP3K120.49991609
119PDPK10.48939695
120BCR0.46723036
121PHKG20.44553952
122PHKG10.44553952
123CSNK1D0.44135518
124CDK40.43952044
125IGF1R0.43554237
126ILK0.43435967
127MAP3K50.43412191
128PRKCG0.41827666
129EPHA40.41760697
130MAP2K10.40680224
131PRKCB0.39823483
132SGK20.39733271
133RET0.39028108
134CAMKK10.37865197
135PBK0.37364345
136PDK20.36167849
137PDK10.34786640
138RIPK40.34600743
139ICK0.33885123
140EGFR0.33293774
141MTOR0.31648465
142PKN10.31509730
143CSNK1G20.31493617
144CAMK10.31087326
145CSNK1G30.31073893
146MAP3K60.30876437
147CAMK40.30051488
148MAP3K20.28398832
149CAMK2A0.28336405
150CSNK1A10.28170910
151SGK2230.25320010
152SGK4940.25320010
153MAP3K10.24951720
154PRKCA0.24798008
155ABL10.21747245
156CSNK1A1L0.21169493
157KIT0.21078736
158IRAK20.20782291
159ITK0.19646112
160BLK0.18795634
161LYN0.18629409
162IRAK10.18189381

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.53386430
2Nitrogen metabolism_Homo sapiens_hsa009103.62149950
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.39265206
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.37979228
5Arginine biosynthesis_Homo sapiens_hsa002203.06469357
6Complement and coagulation cascades_Homo sapiens_hsa046102.78720550
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.70651099
8Tryptophan metabolism_Homo sapiens_hsa003802.68501360
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.65666224
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54812207
11Fatty acid degradation_Homo sapiens_hsa000712.48631686
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39146718
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26216161
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15982156
15Butanoate metabolism_Homo sapiens_hsa006502.15615912
16Peroxisome_Homo sapiens_hsa041462.06556034
17Chemical carcinogenesis_Homo sapiens_hsa052041.97304111
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.95211752
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.94869884
20Propanoate metabolism_Homo sapiens_hsa006401.93175195
21Histidine metabolism_Homo sapiens_hsa003401.90925793
22PPAR signaling pathway_Homo sapiens_hsa033201.85146313
23Fatty acid metabolism_Homo sapiens_hsa012121.79787702
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.79548450
25Staphylococcus aureus infection_Homo sapiens_hsa051501.78300454
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74017941
27Retinol metabolism_Homo sapiens_hsa008301.71909966
28Caffeine metabolism_Homo sapiens_hsa002321.71815562
29beta-Alanine metabolism_Homo sapiens_hsa004101.71370933
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67419816
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63652117
32Selenocompound metabolism_Homo sapiens_hsa004501.58933765
33Phenylalanine metabolism_Homo sapiens_hsa003601.56500371
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50485838
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49366616
36Bile secretion_Homo sapiens_hsa049761.48494686
37Tyrosine metabolism_Homo sapiens_hsa003501.44748942
38Sulfur metabolism_Homo sapiens_hsa009201.36129759
39Pyruvate metabolism_Homo sapiens_hsa006201.35075189
40Fatty acid elongation_Homo sapiens_hsa000621.34230702
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.30332889
42Starch and sucrose metabolism_Homo sapiens_hsa005001.27366016
43Folate biosynthesis_Homo sapiens_hsa007901.22357384
44ABC transporters_Homo sapiens_hsa020101.19445165
45Steroid biosynthesis_Homo sapiens_hsa001001.19356900
46Biosynthesis of amino acids_Homo sapiens_hsa012301.19344879
47Fat digestion and absorption_Homo sapiens_hsa049751.16998138
48Carbon metabolism_Homo sapiens_hsa012001.12333212
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01252287
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00549243
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.98962206
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.97978086
53Arginine and proline metabolism_Homo sapiens_hsa003300.96635247
54Sulfur relay system_Homo sapiens_hsa041220.95700917
55Vitamin B6 metabolism_Homo sapiens_hsa007500.95258071
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86119855
57Vitamin digestion and absorption_Homo sapiens_hsa049770.84502254
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81352366
59Lysine degradation_Homo sapiens_hsa003100.80545651
60One carbon pool by folate_Homo sapiens_hsa006700.78611859
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69039570
62Glutathione metabolism_Homo sapiens_hsa004800.63784526
63Platelet activation_Homo sapiens_hsa046110.62069383
64Ether lipid metabolism_Homo sapiens_hsa005650.58329601
65Pentose phosphate pathway_Homo sapiens_hsa000300.58236548
66Phototransduction_Homo sapiens_hsa047440.57431698
67* Glycerolipid metabolism_Homo sapiens_hsa005610.52626898
68Fatty acid biosynthesis_Homo sapiens_hsa000610.51591995
69Serotonergic synapse_Homo sapiens_hsa047260.50659316
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45641514
71* Metabolic pathways_Homo sapiens_hsa011000.45217772
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42636201
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38679573
74Prion diseases_Homo sapiens_hsa050200.34006540
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30124406
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29305472
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27317721
78Galactose metabolism_Homo sapiens_hsa000520.26106208
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24912780
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.24431987
81Sphingolipid metabolism_Homo sapiens_hsa006000.23788783
82Linoleic acid metabolism_Homo sapiens_hsa005910.22885503
83Insulin resistance_Homo sapiens_hsa049310.22242522
84Fructose and mannose metabolism_Homo sapiens_hsa000510.22118381
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.20300082
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19714514
87Mineral absorption_Homo sapiens_hsa049780.15920406
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.15364712
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.14037413
90Oxidative phosphorylation_Homo sapiens_hsa001900.13208428
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.11588283
92Olfactory transduction_Homo sapiens_hsa047400.10452998
93Glucagon signaling pathway_Homo sapiens_hsa049220.07871972
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.07700202
95Pertussis_Homo sapiens_hsa051330.03808528
96GABAergic synapse_Homo sapiens_hsa047270.02867703
97Collecting duct acid secretion_Homo sapiens_hsa049660.02798004
98AMPK signaling pathway_Homo sapiens_hsa041520.00416989
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2521367
100Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2519921
101Bladder cancer_Homo sapiens_hsa05219-0.2477252
102Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2461590
103Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2390999
104Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1974386
105Renin-angiotensin system_Homo sapiens_hsa04614-0.1945370
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1925003
107Hepatitis C_Homo sapiens_hsa05160-0.1827209
108Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1725229
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1720013
110Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1673639
111Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1616574
112Regulation of autophagy_Homo sapiens_hsa04140-0.1502248
113Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1384399
114African trypanosomiasis_Homo sapiens_hsa05143-0.1306552
115Insulin signaling pathway_Homo sapiens_hsa04910-0.1129755
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1088448
117Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0846444
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0698325
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0425226

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