LIPE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sequestering of triglyceride (GO:0010889)8.79997048
2* triglyceride catabolic process (GO:0019433)8.31540014
3* neutral lipid catabolic process (GO:0046461)7.36069861
4* acylglycerol catabolic process (GO:0046464)7.36069861
5viral transcription (GO:0019083)6.61813996
6ribosomal small subunit assembly (GO:0000028)6.53212879
7translational termination (GO:0006415)6.34287595
8fatty acid homeostasis (GO:0055089)6.33524039
9lipid storage (GO:0019915)5.81454811
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.72613808
11cotranslational protein targeting to membrane (GO:0006613)5.63366042
12protein targeting to ER (GO:0045047)5.58915734
13transcytosis (GO:0045056)5.58378176
14ribosomal small subunit biogenesis (GO:0042274)5.57711479
15NADH metabolic process (GO:0006734)5.47624374
16* glycerolipid catabolic process (GO:0046503)5.35169976
17response to dietary excess (GO:0002021)5.34175002
18translational elongation (GO:0006414)5.32946888
19establishment of protein localization to endoplasmic reticulum (GO:0072599)5.32344685
20regulation of cholesterol storage (GO:0010885)5.31916665
21protein localization to endoplasmic reticulum (GO:0070972)5.30820194
22peptidyl-threonine dephosphorylation (GO:0035970)5.26057705
23protein heterotrimerization (GO:0070208)5.24468152
24regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033395.23701620
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.22453337
26platelet dense granule organization (GO:0060155)5.22216489
27regulation of glycogen (starch) synthase activity (GO:2000465)5.15910809
28lipid particle organization (GO:0034389)5.07672772
29plasma lipoprotein particle clearance (GO:0034381)5.07512703
30triglyceride biosynthetic process (GO:0019432)5.06883648
31DNA deamination (GO:0045006)5.06355219
32brown fat cell differentiation (GO:0050873)5.04647867
33white fat cell differentiation (GO:0050872)5.01597110
34negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)4.95710657
35biotin metabolic process (GO:0006768)4.94270489
36positive regulation of glomerulus development (GO:0090193)4.93965293
37lymphoid progenitor cell differentiation (GO:0002320)4.91243846
38negative regulation of erythrocyte differentiation (GO:0045647)4.90743195
39negative regulation of granulocyte differentiation (GO:0030853)4.86848440
40viral life cycle (GO:0019058)4.82686689
41negative regulation of metanephros development (GO:0072217)4.81610136
42polyol transport (GO:0015791)4.81234881
43acylglycerol biosynthetic process (GO:0046463)4.80598313
44neutral lipid biosynthetic process (GO:0046460)4.80598313
45regulation of cAMP-dependent protein kinase activity (GO:2000479)4.78730118
46pattern specification involved in kidney development (GO:0061004)4.74892468
47positive regulation of lipid storage (GO:0010884)4.70771686
48cellular response to epinephrine stimulus (GO:0071872)4.70067646
49cellular protein complex disassembly (GO:0043624)4.66024898
50positive regulation of cellular amine metabolic process (GO:0033240)4.61676963
51mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.61624892
52nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.61571327
53negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.58793073
54positive regulation of cholesterol efflux (GO:0010875)4.56311912
55regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)4.54123702
56fatty acid transmembrane transport (GO:1902001)4.52371219
57regulation of apoptotic process involved in morphogenesis (GO:1902337)4.48561725
58endothelium development (GO:0003158)4.47417684
59ethanol oxidation (GO:0006069)4.39597713
60CDP-diacylglycerol biosynthetic process (GO:0016024)4.38914562
61nephron tubule formation (GO:0072079)4.38780368
62ovulation from ovarian follicle (GO:0001542)4.35967953
63respiratory chain complex IV assembly (GO:0008535)4.34479453
64negative regulation of macrophage differentiation (GO:0045650)4.34359328
65translational initiation (GO:0006413)4.32019816
66response to interferon-alpha (GO:0035455)4.29195616
67endosome to pigment granule transport (GO:0043485)4.27971127
68endosome to melanosome transport (GO:0035646)4.27971127
69maturation of SSU-rRNA (GO:0030490)4.24535204
70CDP-diacylglycerol metabolic process (GO:0046341)4.23354869
71regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.22602287
72negative regulation of phagocytosis (GO:0050765)4.20240618
73* triglyceride metabolic process (GO:0006641)4.19248800
74definitive hemopoiesis (GO:0060216)4.12986012
75protein complex disassembly (GO:0043241)4.07064162
76negative regulation of protein autophosphorylation (GO:0031953)4.06890475
77antigen processing and presentation via MHC class Ib (GO:0002475)4.06610413
78GDP-mannose metabolic process (GO:0019673)4.02297431
79response to phenylpropanoid (GO:0080184)4.00160060
80response to epinephrine (GO:0071871)3.92103656
81regulation of macrophage derived foam cell differentiation (GO:0010743)3.90567043
82positive regulation of cholesterol transport (GO:0032376)3.89683056
83positive regulation of sterol transport (GO:0032373)3.89683056
84retina vasculature morphogenesis in camera-type eye (GO:0061299)3.89561609
85negative regulation of smooth muscle cell migration (GO:0014912)3.89084599
86telomere maintenance via semi-conservative replication (GO:0032201)3.88572087
87oxaloacetate metabolic process (GO:0006107)3.88259976
88* acylglycerol metabolic process (GO:0006639)3.87906587
89urogenital system development (GO:0001655)3.86638807
90* neutral lipid metabolic process (GO:0006638)3.82451878
91macromolecular complex disassembly (GO:0032984)3.81314424
92negative regulation of amino acid transport (GO:0051956)3.80252478
93alpha-linolenic acid metabolic process (GO:0036109)3.77523647
94negative regulation of gluconeogenesis (GO:0045721)3.75401737
95positive regulation of hormone metabolic process (GO:0032352)3.75330787
96response to interferon-beta (GO:0035456)3.74561739
97positive regulation of glycolytic process (GO:0045821)3.73328664
98mature B cell differentiation involved in immune response (GO:0002313)3.72025372
99protein targeting to membrane (GO:0006612)3.71656062
100mesonephros development (GO:0001823)3.71153415
101fatty-acyl-CoA biosynthetic process (GO:0046949)3.71024015
102fatty-acyl-CoA metabolic process (GO:0035337)3.70018074
103fucose catabolic process (GO:0019317)3.69633315
104L-fucose metabolic process (GO:0042354)3.69633315
105L-fucose catabolic process (GO:0042355)3.69633315
106positive regulation of glycoprotein biosynthetic process (GO:0010560)3.68048245
107facial nerve structural organization (GO:0021612)3.67725589
108regulation of triglyceride catabolic process (GO:0010896)3.62789448
109acyl-CoA biosynthetic process (GO:0071616)3.60503664
110thioester biosynthetic process (GO:0035384)3.60503664
111glycerol metabolic process (GO:0006071)3.60173651
112positive regulation of lipoprotein lipase activity (GO:0051006)3.60092551
113positive regulation of triglyceride lipase activity (GO:0061365)3.60092551
114regulation of gonadotropin secretion (GO:0032276)3.59846083
115regulation of lipid storage (GO:0010883)3.58276957
116positive regulation of metanephros development (GO:0072216)3.57234686
117ribosomal large subunit biogenesis (GO:0042273)3.57143088
118negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.56585186
119primary alcohol metabolic process (GO:0034308)3.56217862
120negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.55847982
121positive regulation of glucose import (GO:0046326)3.54759872
122mannosylation (GO:0097502)3.54334104
123valine metabolic process (GO:0006573)3.52956265
124N-acetylneuraminate metabolic process (GO:0006054)3.52738074
125positive regulation of cellular response to insulin stimulus (GO:1900078)3.52186368
126tricarboxylic acid metabolic process (GO:0072350)3.51450107
127phosphatidic acid metabolic process (GO:0046473)3.51274261
128phosphatidic acid biosynthetic process (GO:0006654)3.51274261
129regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.48771687
130cGMP-mediated signaling (GO:0019934)3.46033385
131retinol metabolic process (GO:0042572)3.45582708
132deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.42641779
133regulation of receptor binding (GO:1900120)3.41983281
134cellular response to lithium ion (GO:0071285)3.38258395
135generation of neurons (GO:0048699)3.37536182
136triglyceride homeostasis (GO:0070328)3.34935021
137acylglycerol homeostasis (GO:0055090)3.34935021
138negative regulation of lipid catabolic process (GO:0050995)3.33014065
139carnitine shuttle (GO:0006853)3.32791927
140long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.32641593
141nuclear-transcribed mRNA catabolic process (GO:0000956)3.32476283
142protein localization to cell surface (GO:0034394)3.32414739
143positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.31437816
144glomerular filtration (GO:0003094)3.31245928
145ethanol metabolic process (GO:0006067)3.30568004
146regulation of type B pancreatic cell apoptotic process (GO:2000674)3.30565837
147positive regulation of T cell mediated cytotoxicity (GO:0001916)3.29843019
148positive regulation of fatty acid metabolic process (GO:0045923)3.29283836
149positive regulation of insulin receptor signaling pathway (GO:0046628)3.28141911
150negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.27477752
151negative regulation of DNA biosynthetic process (GO:2000279)3.26603307
152positive regulation of protein export from nucleus (GO:0046827)3.25979812
153cytochrome complex assembly (GO:0017004)3.23745471
154translation (GO:0006412)3.23187441
155amino sugar catabolic process (GO:0046348)3.21057414
156negative regulation of smooth muscle cell proliferation (GO:0048662)3.19901643
157mRNA catabolic process (GO:0006402)3.16343817
158antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16063479
159antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.16063479
160* diacylglycerol metabolic process (GO:0046339)3.15428690
161thyroid gland development (GO:0030878)3.14659607
162regulation of protein kinase A signaling (GO:0010738)3.14259623
163negative regulation of lipid storage (GO:0010888)3.13093114
164regulation of lipid catabolic process (GO:0050994)3.12806378
165metanephric nephron tubule development (GO:0072234)3.12791729
166metanephric tubule development (GO:0072170)3.12791729
167GPI anchor biosynthetic process (GO:0006506)3.12552257
168L-serine transport (GO:0015825)3.12149895
169positive regulation of B cell differentiation (GO:0045579)3.12094001
170telomere maintenance via recombination (GO:0000722)3.11408739
171alditol metabolic process (GO:0019400)3.10432954
172fatty acid beta-oxidation (GO:0006635)3.08723667
173secretory granule organization (GO:0033363)3.06047784
174megakaryocyte development (GO:0035855)3.04129780
175regulation of T cell mediated cytotoxicity (GO:0001914)3.02948623
176mesenchymal to epithelial transition (GO:0060231)3.01748031
177nephron epithelium development (GO:0072009)3.00397854
178cellular response to thyroid hormone stimulus (GO:0097067)2.98450898
179phospholipid scrambling (GO:0017121)2.95831887
180lymph node development (GO:0048535)2.95709673
181regulation of hormone metabolic process (GO:0032350)2.95424096
182DNA replication initiation (GO:0006270)2.95209843
183RNA catabolic process (GO:0006401)2.94443053
184mature B cell differentiation (GO:0002335)2.94396407
185positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.92210332
186DNA strand elongation involved in DNA replication (GO:0006271)2.91838406
187C-terminal protein lipidation (GO:0006501)2.91162699
188genitalia morphogenesis (GO:0035112)2.90939602
189ribonucleoprotein complex biogenesis (GO:0022613)2.88541008
190pseudouridine synthesis (GO:0001522)2.87827561
191response to folic acid (GO:0051593)2.86568194
192cranial nerve morphogenesis (GO:0021602)2.82093756
193transcription elongation from RNA polymerase III promoter (GO:0006385)2.81477232
194termination of RNA polymerase III transcription (GO:0006386)2.81477232
195DNA strand elongation (GO:0022616)2.80506294
196postsynaptic membrane organization (GO:0001941)2.79202329
197dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.78520371
198low-density lipoprotein particle clearance (GO:0034383)11.5969472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.97117255
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.61012239
3SCL_19346495_ChIP-Seq_HPC-7_Human4.01001584
4* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.49511780
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47670102
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.47524760
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.40176590
8CLOCK_20551151_ChIP-Seq_293T_Human3.25557105
9* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.19694709
10NOTCH1_21737748_ChIP-Seq_TLL_Human3.18990789
11TAL1_20887958_ChIP-Seq_HPC-7_Mouse3.11371676
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.09855270
13FLI1_20887958_ChIP-Seq_HPC-7_Mouse3.05216236
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.95845605
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.94976342
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.94024881
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.88902079
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.86724124
19* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.84783731
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.58875864
21ERG_20887958_ChIP-Seq_HPC-7_Mouse2.57843587
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.56431714
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.51169239
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.49821518
25GATA1_22025678_ChIP-Seq_K562_Human2.48308096
26* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.46728989
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41843622
28* RXR_22158963_ChIP-Seq_LIVER_Mouse2.38718150
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.36472135
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.34280942
31* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.26618907
32ETS1_20019798_ChIP-Seq_JURKAT_Human2.25892030
33* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.25093434
34SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.24191360
35EST1_17652178_ChIP-ChIP_JURKAT_Human2.21793131
36LXR_22158963_ChIP-Seq_LIVER_Mouse2.18755245
37E2F7_22180533_ChIP-Seq_HELA_Human2.15059316
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14890768
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13696244
40SPI1_23547873_ChIP-Seq_NB4_Human2.13395867
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.11572625
42VDR_23849224_ChIP-Seq_CD4+_Human2.11418023
43VDR_21846776_ChIP-Seq_THP-1_Human2.08995108
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07182201
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.06342754
46* PPARG_19300518_ChIP-PET_3T3-L1_Mouse10.3782185
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.99180996
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.95870302
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93422403
50* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.92703742
51PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.91173161
52FOXP3_21729870_ChIP-Seq_TREG_Human1.90679568
53VDR_24763502_ChIP-Seq_THP-1_Human1.88908534
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86989379
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81949773
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.81120839
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80289599
58GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.79410987
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.79002358
60CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.78636005
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.77399154
62XRN2_22483619_ChIP-Seq_HELA_Human1.76747699
63TBX20_22080862_ChIP-Seq_HEART_Mouse1.74619343
64TBX20_22328084_ChIP-Seq_HEART_Mouse1.74619343
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.72607081
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.71864957
67CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69531051
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.68098877
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.62726166
70MYC_22102868_ChIP-Seq_BL_Human1.62110498
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60908799
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60210717
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59836788
74RUNX1_22412390_ChIP-Seq_EML_Mouse1.58460268
75ZNF263_19887448_ChIP-Seq_K562_Human1.57852410
76BP1_19119308_ChIP-ChIP_Hs578T_Human1.56718111
77DCP1A_22483619_ChIP-Seq_HELA_Human1.56302347
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.54183812
79KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52939272
80* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.51767025
81TTF2_22483619_ChIP-Seq_HELA_Human1.48708658
82SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46434941
83CIITA_25753668_ChIP-Seq_RAJI_Human1.46205233
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.42023003
85* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41571253
86RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40112766
87EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40112766
88MYB_26560356_Chip-Seq_TH2_Human1.38474048
89LXR_22292898_ChIP-Seq_THP-1_Human1.38337922
90GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36207867
91NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.35136684
92MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35012679
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33588041
94MAF_26560356_Chip-Seq_TH1_Human1.32696478
95THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32405635
96* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31384330
97ELK1_19687146_ChIP-ChIP_HELA_Human1.30696207
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28173595
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27340795
100PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27147017
101DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26796503
102NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26326548
103WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25801049
104CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25632993
105EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25486811
106GABP_19822575_ChIP-Seq_HepG2_Human1.24955212
107* MYB_26560356_Chip-Seq_TH1_Human1.24287804
108ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22525993
109SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21882975
110RAD21_21589869_ChIP-Seq_MESCs_Mouse1.21683186
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21506549
112KDM2B_26808549_Chip-Seq_K562_Human1.20136167
113EED_16625203_ChIP-ChIP_MESCs_Mouse1.19894554
114* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19128470
115SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18434868
116EZH2_22144423_ChIP-Seq_EOC_Human1.17834892
117UTX_26944678_Chip-Seq_JUKART_Human1.16598535
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16245238
119SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16175931
120ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15307769
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13803760
122PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13017832
123GATA1_19941827_ChIP-Seq_MEL_Mouse1.11651713
124NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11647782
125SA1_22415368_ChIP-Seq_MEFs_Mouse1.11112493
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10959786
127SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10463891
128CTCF_27219007_Chip-Seq_Bcells_Human1.10368547
129SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09960050
130E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09091132
131ELK1_22589737_ChIP-Seq_MCF10A_Human1.07070479
132SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05639001
133SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05379403
134SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04322770
135ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03493600
136TET1_21490601_ChIP-Seq_MESCs_Mouse1.03141571
137NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02834127
138ERG_21242973_ChIP-ChIP_JURKAT_Human1.02641159
139BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02399072
140NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02321057
141YY1_21170310_ChIP-Seq_MESCs_Mouse1.01942653
142JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01899962
143TCF7_22412390_ChIP-Seq_EML_Mouse1.00475570
144PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99898622
145MYC_18940864_ChIP-ChIP_HL60_Human0.98672450
146KLF4_19829295_ChIP-Seq_ESCs_Human0.98630859
147P68_20966046_ChIP-Seq_HELA_Human0.98353598
148WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98076610
149MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97991381
150IRF8_21731497_ChIP-ChIP_J774_Mouse0.97824352
151CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97654706
152SMC4_20622854_ChIP-Seq_HELA_Human0.97532627
153* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97462311
154FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97378846
155TP63_17297297_ChIP-ChIP_HaCaT_Human0.97321686
156P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97145759
157KDM2B_26808549_Chip-Seq_DND41_Human0.95551574
158E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95020695
159IRF8_27001747_Chip-Seq_BMDM_Mouse0.94875340
160SPI1_23127762_ChIP-Seq_K562_Human0.94449462
161SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93245691
162MAF_26560356_Chip-Seq_TH2_Human0.91864687
163EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91575032
164* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90460491
165NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90129361
166EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88844716
167STAT1_20625510_ChIP-Seq_HELA_Human0.88551489
168UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88151751
169CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88143744
170CJUN_26792858_Chip-Seq_BT549_Human0.87954973
171PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87443560
172IGF1R_20145208_ChIP-Seq_DFB_Human0.87248687
173SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86626216
174CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86287256
175PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86142486
176BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86084270
177EZH2_27304074_Chip-Seq_ESCs_Mouse0.85830218
178HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84098877
179RACK7_27058665_Chip-Seq_MCF-7_Human0.83849935
180TP53_20018659_ChIP-ChIP_R1E_Mouse0.83606918
181NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.82940796
182DROSHA_22980978_ChIP-Seq_HELA_Human0.82045597
183IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81695994
184EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.81207395
185CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.81048988
186EZH2_27294783_Chip-Seq_ESCs_Mouse0.80790161
187SA1_27219007_Chip-Seq_ERYTHROID_Human0.79973258
188SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79874632
189RNF2_27304074_Chip-Seq_ESCs_Mouse0.78931811
190KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.78286085
191EP300_21415370_ChIP-Seq_HL-1_Mouse0.77192636
192CBP_21632823_ChIP-Seq_H3396_Human0.75066889
193SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.74783907
194SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.74618296
195CTCF_27219007_Chip-Seq_ERYTHROID_Human0.74285007
196KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74146847
197SA1_27219007_Chip-Seq_Bcells_Human0.72390940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose9.22877637
2MP0009379_abnormal_foot_pigmentation6.80242630
3* MP0005666_abnormal_adipose_tissue5.41164432
4MP0004185_abnormal_adipocyte_glucose4.26706299
5* MP0002971_abnormal_brown_adipose4.12980476
6* MP0004130_abnormal_muscle_cell4.07502572
7* MP0005375_adipose_tissue_phenotype4.05347955
8MP0003724_increased_susceptibility_to3.96611257
9MP0005174_abnormal_tail_pigmentation3.78797544
10MP0002396_abnormal_hematopoietic_system3.68048281
11MP0001188_hyperpigmentation3.23895773
12MP0005409_darkened_coat_color3.07183547
13MP0010329_abnormal_lipoprotein_level2.95641828
14MP0004147_increased_porphyrin_level2.84866376
15* MP0009115_abnormal_fat_cell2.80586984
16MP0005075_abnormal_melanosome_morpholog2.71436932
17MP0001545_abnormal_hematopoietic_system2.59857695
18MP0005397_hematopoietic_system_phenotyp2.59857695
19MP0006138_congestive_heart_failure2.58478370
20MP0000003_abnormal_adipose_tissue2.55391363
21* MP0002970_abnormal_white_adipose2.54953157
22MP0005535_abnormal_body_temperature2.54879796
23MP0000490_abnormal_crypts_of2.51022357
24MP0001986_abnormal_taste_sensitivity2.46552205
25MP0000685_abnormal_immune_system2.44214706
26MP0001835_abnormal_antigen_presentation2.41708355
27MP0009785_altered_susceptibility_to2.40567304
28MP0002095_abnormal_skin_pigmentation2.40453810
29* MP0005334_abnormal_fat_pad2.37436817
30MP0006292_abnormal_olfactory_placode2.35984439
31MP0000015_abnormal_ear_pigmentation2.29276919
32MP0003011_delayed_dark_adaptation2.23199090
33MP0000681_abnormal_thyroid_gland2.20951013
34MP0000465_gastrointestinal_hemorrhage2.20175323
35MP0005671_abnormal_response_to2.18833269
36MP0005275_abnormal_skin_tensile2.14518851
37MP0008438_abnormal_cutaneous_collagen2.11623592
38MP0003303_peritoneal_inflammation2.08004997
39MP0003879_abnormal_hair_cell2.07637117
40* MP0003959_abnormal_lean_body2.02668855
41MP0004808_abnormal_hematopoietic_stem2.00606146
42MP0000751_myopathy1.98849120
43MP0003690_abnormal_glial_cell1.97648989
44MP0005503_abnormal_tendon_morphology1.91053649
45* MP0002118_abnormal_lipid_homeostasis1.89628418
46MP0003828_pulmonary_edema1.85304746
47MP0005025_abnormal_response_to1.79800862
48MP0003646_muscle_fatigue1.75161899
49* MP0005448_abnormal_energy_balance1.72902507
50MP0000372_irregular_coat_pigmentation1.72849974
51MP0003436_decreased_susceptibility_to1.71632151
52MP0005167_abnormal_blood-brain_barrier1.70059454
53MP0002398_abnormal_bone_marrow1.68594465
54MP0003763_abnormal_thymus_physiology1.67529559
55MP0009333_abnormal_splenocyte_physiolog1.57805262
56MP0003705_abnormal_hypodermis_morpholog1.56870807
57* MP0005452_abnormal_adipose_tissue1.56439850
58MP0002148_abnormal_hypersensitivity_rea1.56390338
59MP0000689_abnormal_spleen_morphology1.56353169
60MP0008007_abnormal_cellular_replicative1.54105196
61MP0005000_abnormal_immune_tolerance1.52930095
62MP0000013_abnormal_adipose_tissue1.50617224
63MP0002723_abnormal_immune_serum1.47536174
64MP0010155_abnormal_intestine_physiology1.47452845
65MP0001800_abnormal_humoral_immune1.46923493
66MP0002420_abnormal_adaptive_immunity1.46452322
67MP0001873_stomach_inflammation1.46142996
68MP0001819_abnormal_immune_cell1.43380765
69MP0001661_extended_life_span1.41753351
70MP0002909_abnormal_adrenal_gland1.40792115
71MP0003136_yellow_coat_color1.39216409
72MP0003191_abnormal_cellular_cholesterol1.38610023
73MP0005464_abnormal_platelet_physiology1.38519855
74MP0002722_abnormal_immune_system1.37772805
75MP0005385_cardiovascular_system_phenoty1.36859268
76MP0001544_abnormal_cardiovascular_syste1.36859268
77MP0003656_abnormal_erythrocyte_physiolo1.35895990
78MP0002108_abnormal_muscle_morphology1.35786199
79MP0000716_abnormal_immune_system1.35607395
80MP0003866_abnormal_defecation1.33920327
81MP0002452_abnormal_antigen_presenting1.33819737
82MP0002429_abnormal_blood_cell1.28644119
83MP0002177_abnormal_outer_ear1.27976819
84MP0004272_abnormal_basement_membrane1.27625639
85* MP0002078_abnormal_glucose_homeostasis1.26697045
86MP0002876_abnormal_thyroid_physiology1.26367601
87MP0003950_abnormal_plasma_membrane1.25829765
88MP0003693_abnormal_embryo_hatching1.25350033
89MP0003279_aneurysm1.25120479
90MP0002933_joint_inflammation1.23413505
91MP0004381_abnormal_hair_follicle1.22662089
92MP0002166_altered_tumor_susceptibility1.22625666
93MP0006036_abnormal_mitochondrial_physio1.22074092
94MP0006054_spinal_hemorrhage1.21174186
95MP0002419_abnormal_innate_immunity1.19964631
96MP0009780_abnormal_chondrocyte_physiolo1.16642523
97MP0005647_abnormal_sex_gland1.15575519
98MP0001853_heart_inflammation1.14375980
99MP0000049_abnormal_middle_ear1.09834106
100MP0001663_abnormal_digestive_system1.05631692
101MP0002295_abnormal_pulmonary_circulatio1.05575213
102MP0000249_abnormal_blood_vessel1.04810522
103MP0000759_abnormal_skeletal_muscle1.03160779
104MP0002132_abnormal_respiratory_system1.03092061
105MP0004087_abnormal_muscle_fiber1.02874810
106MP0004215_abnormal_myocardial_fiber0.99656299
107MP0008469_abnormal_protein_level0.98565908
108MP0001501_abnormal_sleep_pattern0.98257197
109* MP0003948_abnormal_gas_homeostasis0.94125187
110MP0008058_abnormal_DNA_repair0.94007307
111MP0005164_abnormal_response_to0.93853562
112MP0001845_abnormal_inflammatory_respons0.93473576
113MP0002102_abnormal_ear_morphology0.93317839
114MP0001764_abnormal_homeostasis0.92315480
115MP0000631_abnormal_neuroendocrine_gland0.90317889
116MP0005387_immune_system_phenotype0.89573504
117MP0001790_abnormal_immune_system0.89573504
118MP0001881_abnormal_mammary_gland0.89299273
119MP0000703_abnormal_thymus_morphology0.89013118
120MP0000767_abnormal_smooth_muscle0.88728443
121MP0002006_tumorigenesis0.88658439
122MP0002019_abnormal_tumor_incidence0.87283190
123MP0003938_abnormal_ear_development0.86211227
124* MP0000609_abnormal_liver_physiology0.84110822
125MP0001958_emphysema0.83719904
126MP0002938_white_spotting0.82649065
127MP0001533_abnormal_skeleton_physiology0.82361354
128MP0003786_premature_aging0.81277543
129MP0002075_abnormal_coat/hair_pigmentati0.79957589
130MP0005365_abnormal_bile_salt0.78922395
131MP0001727_abnormal_embryo_implantation0.78777087
132MP0008775_abnormal_heart_ventricle0.77728166
133MP0006276_abnormal_autonomic_nervous0.77012317
134MP0005595_abnormal_vascular_smooth0.75869911
135* MP0003953_abnormal_hormone_level0.75582957
136MP0005084_abnormal_gallbladder_morpholo0.75170560
137MP0004084_abnormal_cardiac_muscle0.75156784
138MP0000477_abnormal_intestine_morphology0.74849769
139MP0005620_abnormal_muscle_contractility0.74681649
140MP0002972_abnormal_cardiac_muscle0.73713521
141MP0002405_respiratory_system_inflammati0.73524128
142* MP0005584_abnormal_enzyme/coenzyme_acti0.72641063
143MP0008569_lethality_at_weaning0.72059151
144MP0000749_muscle_degeneration0.70495725
145MP0010368_abnormal_lymphatic_system0.69698057
146MP0000858_altered_metastatic_potential0.69307475
147MP0002133_abnormal_respiratory_system0.68995972
148MP0005388_respiratory_system_phenotype0.68995972
149MP0010094_abnormal_chromosome_stability0.68849731
150MP0004782_abnormal_surfactant_physiolog0.68428397
151MP0001879_abnormal_lymphatic_vessel0.67055594
152MP0003186_abnormal_redox_activity0.65556102
153MP0003075_altered_response_to0.65403798
154MP0000230_abnormal_systemic_arterial0.64294807
155MP0004036_abnormal_muscle_relaxation0.63485309
156MP0004957_abnormal_blastocyst_morpholog0.62600279
157MP0005379_endocrine/exocrine_gland_phen0.62186091
158MP0005636_abnormal_mineral_homeostasis0.61858843
159MP0000343_altered_response_to0.61613921
160MP0002796_impaired_skin_barrier0.61289693
161MP0004142_abnormal_muscle_tone0.60702436
162MP0001348_abnormal_lacrimal_gland0.60177279
163MP0009643_abnormal_urine_homeostasis0.59692865
164MP0003566_abnormal_cell_adhesion0.59649624
165MP0010630_abnormal_cardiac_muscle0.57886620
166MP0002638_abnormal_pupillary_reflex0.57830860
167MP0008260_abnormal_autophagy0.57215289
168MP0005381_digestive/alimentary_phenotyp0.55828207
169MP0001177_atelectasis0.55344637
170MP0000470_abnormal_stomach_morphology0.54689895
171MP0003943_abnormal_hepatobiliary_system0.52667010
172MP0005508_abnormal_skeleton_morphology0.51319209
173MP0000613_abnormal_salivary_gland0.51057291
174MP0000313_abnormal_cell_death0.50738224
175MP0003137_abnormal_impulse_conducting0.50647573
176MP0004858_abnormal_nervous_system0.49903378
177MP0005369_muscle_phenotype0.48557575
178MP0003091_abnormal_cell_migration0.47728019
179MP0009672_abnormal_birth_weight0.47294454
180MP0003448_altered_tumor_morphology0.45690606
181MP0005165_increased_susceptibility_to0.44962509
182MP0001614_abnormal_blood_vessel0.44805514

Predicted human phenotypes

RankGene SetZ-score
1Oligomenorrhea (HP:0000876)8.63662082
2Hypertriglyceridemia (HP:0002155)7.57192312
3Acanthosis nigricans (HP:0000956)7.54673754
4Reduced antithrombin III activity (HP:0001976)7.13155283
5Hypothermia (HP:0002045)6.51696529
6Type I transferrin isoform profile (HP:0003642)6.43761054
7Thyroid-stimulating hormone excess (HP:0002925)6.00788288
8Abnormality of cells of the erythroid lineage (HP:0012130)5.27261505
9Abnormal number of erythroid precursors (HP:0012131)5.20323178
10Increased variability in muscle fiber diameter (HP:0003557)5.19704482
11Difficulty running (HP:0009046)4.76262831
12Abnormal protein glycosylation (HP:0012346)4.68972816
13Abnormal glycosylation (HP:0012345)4.68972816
14Abnormal isoelectric focusing of serum transferrin (HP:0003160)4.68972816
15Abnormal protein N-linked glycosylation (HP:0012347)4.68972816
16Protrusio acetabuli (HP:0003179)4.63239230
17Abnormality of skeletal muscle fiber size (HP:0012084)4.33060634
18Aplastic anemia (HP:0001915)4.18213823
19Absent rod-and cone-mediated responses on ERG (HP:0007688)4.17351731
20Reticulocytopenia (HP:0001896)4.14180125
21Hyperlipoproteinemia (HP:0010980)4.05167467
22Thrombocytosis (HP:0001894)3.97399895
23Insulin-resistant diabetes mellitus (HP:0000831)3.96555034
24Abnormality of the heme biosynthetic pathway (HP:0010472)3.84423630
25Myocardial infarction (HP:0001658)3.80769929
26Hemorrhage of the eye (HP:0011885)3.73177471
27Abnormal eating behavior (HP:0100738)3.70241543
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.64305249
29Severe visual impairment (HP:0001141)3.63247128
30Bone cyst (HP:0012062)3.62684352
31Growth hormone excess (HP:0000845)3.59942206
32Pigmentary retinal degeneration (HP:0001146)3.47361874
33Muscle fiber splitting (HP:0003555)3.46150816
34Pallor (HP:0000980)3.41953311
35Long foot (HP:0001833)3.41251311
36Elevated erythrocyte sedimentation rate (HP:0003565)3.35647635
37Skin nodule (HP:0200036)3.35416657
38Spinal rigidity (HP:0003306)3.34999434
39Macrocytic anemia (HP:0001972)3.28539068
40Epidermoid cyst (HP:0200040)3.27433507
41Increased connective tissue (HP:0009025)3.26323328
42Hypercortisolism (HP:0001578)3.25723642
43Hepatocellular necrosis (HP:0001404)3.23444057
44Nonprogressive disorder (HP:0003680)3.22226710
45Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.20891367
46Chronic otitis media (HP:0000389)3.19574688
47Axonal loss (HP:0003447)3.12776835
48Increased hepatocellular lipid droplets (HP:0006565)3.10996074
49Nausea (HP:0002018)3.05157418
50Prolonged bleeding time (HP:0003010)3.04761108
51Petechiae (HP:0000967)3.03803246
52Muscle fiber atrophy (HP:0100295)3.01443564
53Prolonged partial thromboplastin time (HP:0003645)2.98994137
54Type 2 muscle fiber atrophy (HP:0003554)2.97237169
55Microvesicular hepatic steatosis (HP:0001414)2.96456346
56Complement deficiency (HP:0004431)2.96110836
57Back pain (HP:0003418)2.96016927
58Subcapsular cataract (HP:0000523)2.93660258
59Polycythemia (HP:0001901)2.91913381
60Ectopia lentis (HP:0001083)2.91823620
61* Insulin resistance (HP:0000855)2.91000753
62IgM deficiency (HP:0002850)2.86674343
63Reduced subcutaneous adipose tissue (HP:0003758)2.86352727
64Exertional dyspnea (HP:0002875)2.86244554
65Decreased activity of mitochondrial respiratory chain (HP:0008972)2.85750821
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.85750821
67Polyphagia (HP:0002591)2.83079817
68Hypercholesterolemia (HP:0003124)2.79481223
69Ankle contracture (HP:0006466)2.78907422
70Lipid accumulation in hepatocytes (HP:0006561)2.77654355
71Myositis (HP:0100614)2.74739828
72Flat occiput (HP:0005469)2.73948219
73Colitis (HP:0002583)2.73879685
74Cortical visual impairment (HP:0100704)2.73834388
75Aortic aneurysm (HP:0004942)2.72569508
76Xanthomatosis (HP:0000991)2.72403350
77Prominent supraorbital ridges (HP:0000336)2.71415057
783-Methylglutaconic aciduria (HP:0003535)2.70964757
79Hepatic necrosis (HP:0002605)2.70597286
80Increased intramyocellular lipid droplets (HP:0012240)2.68534356
81Acute lymphatic leukemia (HP:0006721)2.67196171
82Ileus (HP:0002595)2.66642086
83Aplasia/Hypoplasia of the sacrum (HP:0008517)2.66339702
84Renal Fanconi syndrome (HP:0001994)2.65619814
85Lymphangioma (HP:0100764)2.64079325
86Cerebral aneurysm (HP:0004944)2.63892967
87Abnormality of complement system (HP:0005339)2.60221303
88Microcytic anemia (HP:0001935)2.58917886
89Polar cataract (HP:0010696)2.56897158
90Neck muscle weakness (HP:0000467)2.56678964
91Increased muscle lipid content (HP:0009058)2.54880404
92Abnormal rod and cone electroretinograms (HP:0008323)2.54769847
93Accelerated skeletal maturation (HP:0005616)2.52944296
94Easy fatigability (HP:0003388)2.52273592
95Rhabdomyolysis (HP:0003201)2.52255828
96Striae distensae (HP:0001065)2.52191882
97Frequent falls (HP:0002359)2.51960979
98Panhypogammaglobulinemia (HP:0003139)2.48269879
99Lipoatrophy (HP:0100578)2.46103568
100Epistaxis (HP:0000421)2.44640386
101Abnormal hemoglobin (HP:0011902)2.44256462
102Infantile muscular hypotonia (HP:0008947)2.41227628
103Attenuation of retinal blood vessels (HP:0007843)2.40914965
104Shallow orbits (HP:0000586)2.39045300
105Lower limb hyperreflexia (HP:0002395)2.38007510
106Abnormal platelet function (HP:0011869)2.32821490
107Impaired platelet aggregation (HP:0003540)2.32821490
108Increased serum pyruvate (HP:0003542)2.31818226
109Abnormality of fatty-acid metabolism (HP:0004359)2.30125453
110Pancytopenia (HP:0001876)2.27781128
111Progressive muscle weakness (HP:0003323)2.26226740
112Systemic lupus erythematosus (HP:0002725)2.26095741
113Amyloidosis (HP:0011034)2.26016076
114Cervical subluxation (HP:0003308)2.24481708
115Gowers sign (HP:0003391)2.22184650
116Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.20640169
117Asymmetric septal hypertrophy (HP:0001670)2.19003816
118Abnormality of T cell physiology (HP:0011840)2.18928511
119Respiratory difficulties (HP:0002880)2.18323864
120Abnormality of the nasal mucosa (HP:0000433)2.15767100
121Hypoproteinemia (HP:0003075)2.14672011
122Abnormality of the periventricular white matter (HP:0002518)2.13044974
123Stridor (HP:0010307)2.11285350
124Acute myeloid leukemia (HP:0004808)2.09467960
125Abnormality of glycolysis (HP:0004366)2.09379800
126Vertebral compression fractures (HP:0002953)2.07572118
127Broad metatarsal (HP:0001783)2.06454979
128Abnormality of magnesium homeostasis (HP:0004921)2.04591032
129Hyperpituitarism (HP:0010514)2.04240701
130Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.01821635
131Ragged-red muscle fibers (HP:0003200)2.01413336
132Biconcave vertebral bodies (HP:0004586)2.00775031
133Myoglobinuria (HP:0002913)1.97837285
134Wormian bones (HP:0002645)1.97652025
135Mitochondrial inheritance (HP:0001427)1.97401576
136Thoracic kyphosis (HP:0002942)1.97199895
137Premature rupture of membranes (HP:0001788)1.96919677
138Large hands (HP:0001176)1.96130910
139Abnormality of B cell number (HP:0010975)1.94115730
140B lymphocytopenia (HP:0010976)1.94115730
141Entropion (HP:0000621)1.94051778
142Recurrent bronchitis (HP:0002837)1.94051102
143Abnormality of the columella (HP:0009929)1.94041494
144Agammaglobulinemia (HP:0004432)1.93707014
145Pulmonary artery stenosis (HP:0004415)1.92038496
146Increased serum lactate (HP:0002151)1.91965619
147Purpura (HP:0000979)1.91680493
148Glucose intolerance (HP:0000833)1.91580445
149Hyperbilirubinemia (HP:0002904)1.90968263
150Dilatation of the ascending aorta (HP:0005111)1.90542700
151Erythema (HP:0010783)1.90034589
152Gastrointestinal dysmotility (HP:0002579)1.89896643
153Hypoalphalipoproteinemia (HP:0003233)1.89126772
154Myotonia (HP:0002486)1.88091175
155Atrioventricular block (HP:0001678)1.87278778
156Muscle stiffness (HP:0003552)1.86801385
157Migraine (HP:0002076)1.86114965
158Obstructive sleep apnea (HP:0002870)1.84896969
159Hyporeflexia of lower limbs (HP:0002600)1.83510568
160Vascular tortuosity (HP:0004948)1.83280791
161Mitral valve prolapse (HP:0001634)1.83276609
162Esophageal varix (HP:0002040)1.82758490
163Broad face (HP:0000283)1.82654964
164Hyperalaninemia (HP:0003348)1.82544367
165Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82544367
166Abnormality of alanine metabolism (HP:0010916)1.82544367
167Bradycardia (HP:0001662)1.81727695
168Potter facies (HP:0002009)1.79074572
169Facial shape deformation (HP:0011334)1.79074572
170Megalocornea (HP:0000485)1.78905973
171Amaurosis fugax (HP:0100576)1.78870041
172Pendular nystagmus (HP:0012043)1.78075622
173Venous abnormality (HP:0002624)1.77466625
174Nuclear cataract (HP:0100018)1.77004016
175Mutism (HP:0002300)1.74551711
176Meningitis (HP:0001287)1.74427163
177Impulsivity (HP:0100710)1.73833831
178Congenital, generalized hypertrichosis (HP:0004540)1.73714478
179Dry hair (HP:0011359)1.73146813
180Beaking of vertebral bodies (HP:0004568)1.73024899
181Hypoplasia of the iris (HP:0007676)1.72984702
182Nasal polyposis (HP:0100582)1.72378220
183Abnormality of the lower motor neuron (HP:0002366)1.71669734
184Foot dorsiflexor weakness (HP:0009027)1.70751331
185Recurrent abscess formation (HP:0002722)1.70649556
186Increased CSF lactate (HP:0002490)1.70367022
187True hermaphroditism (HP:0010459)1.69565400
188Exercise-induced myalgia (HP:0003738)1.69416056
189Type II lissencephaly (HP:0007260)1.68365863
190Gastrointestinal stroma tumor (HP:0100723)1.65894077
191Abnormal spermatogenesis (HP:0008669)1.63455705
192Albinism (HP:0001022)1.63246752

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK9.89753519
2TRIB34.31273727
3NLK3.80721652
4RIPK13.50160596
5EPHB23.50143138
6DDR23.12836608
7KIT3.09792242
8NME23.04693281
9SIK13.02603902
10TESK12.97533190
11STK162.97295338
12FES2.86085390
13FLT32.65506785
14ERN12.55029368
15MUSK2.49179523
16TEC2.23724290
17CDK192.22577011
18PIM22.17404527
19WEE12.14266759
20EIF2AK32.13611902
21LATS22.10554920
22MKNK22.09648623
23CAMK1D1.94701794
24CAMKK21.79556544
25* PRKAA21.72434608
26ABL21.69822822
27GRK51.65483259
28TLK11.63330390
29PDGFRA1.63017958
30MKNK11.57528650
31CDK61.50785225
32CSF1R1.39217981
33PDPK11.38125250
34ARAF1.37586911
35MAP3K131.33459406
36BTK1.30926162
37TGFBR11.30843210
38MATK1.27279905
39TIE11.20646894
40TGFBR21.20495909
41DYRK31.19538205
42CAMK1G1.18081909
43EPHB11.16934505
44BRSK21.15510940
45MAP2K71.14671395
46EPHA31.13699310
47MAP2K11.11633632
48LATS11.10992579
49VRK11.07487697
50TRPM71.07048114
51MAP3K121.06897343
52PRPF4B1.06610931
53EIF2AK11.06215493
54ACVR1B1.05227616
55PKN21.04583778
56BCKDK0.98600244
57NEK90.97845800
58MOS0.96958902
59BLK0.94379676
60EIF2AK20.93848778
61KDR0.92925695
62GSK3A0.91622941
63TBK10.90739233
64MAP3K60.89629412
65PDGFRB0.89553994
66MAPKAPK50.89547671
67MAPK130.88596952
68MAP4K10.87963365
69MAPK70.87653409
70JAK20.86852489
71BUB10.85807278
72ZAP700.85277367
73CDC42BPA0.83494418
74PDK10.78045222
75PKN10.76906415
76LYN0.75071852
77ADRBK20.74564059
78SCYL20.74020780
79* PRKACG0.71699997
80SYK0.70925583
81CDK90.70688398
82* PRKAA10.70313409
83STK380.69822777
84PAK20.68853418
85MTOR0.68851462
86MAPK110.67816665
87PRKD30.67452561
88PRKD10.67244967
89PTK20.66568265
90JAK10.66438359
91TYRO30.66378701
92STK38L0.65527156
93IRAK40.64569519
94LCK0.63526141
95CDK80.61730309
96CDK70.60822876
97PRKG20.59857432
98YES10.58275790
99RPS6KB20.58134158
100RIPK40.57682611
101MAPKAPK30.57065678
102EEF2K0.56664032
103IGF1R0.56184637
104RET0.55998821
105JAK30.54192655
106MAP2K30.53625380
107KSR20.53526843
108CLK10.53262644
109IKBKB0.51796570
110MAP3K10.51290839
111ILK0.51272758
112DAPK30.50600921
113IRAK30.49610514
114HIPK20.49469813
115IKBKE0.48176550
116MARK10.47959894
117ICK0.46943344
118TAOK30.46391372
119PINK10.45609903
120* MAPK30.45527674
121CDK50.43189766
122RAF10.42293020
123TYK20.41873821
124ABL10.41629358
125PIM10.41475987
126MAP2K40.41229958
127MAP3K110.40376625
128SRPK10.39925209
129AKT20.39791588
130CASK0.39656329
131CSK0.38722709
132INSR0.38260951
133PDK20.37761326
134TTN0.37158612
135* CAMK10.36487095
136* RPS6KA30.36281089
137DYRK1B0.35702122
138FGFR40.35238084
139SRC0.35010733
140PTK2B0.33623436
141BMPR1B0.32524774
142FER0.31637235
143* PRKG10.31632470
144HCK0.30913095
145MAPK150.29092209
146CSNK2A20.29021323
147CCNB10.27192144
148TXK0.27098295
149MARK20.26107874
150TESK20.25932155
151TNK20.25698416
152MAPK120.25635397
153PAK40.25256471
154CSNK2A10.22979900
155LRRK20.22899446
156CDK40.22764566
157PRKD20.21243818
158MYLK0.21033178
159MAP3K70.20405531
160PIK3CG0.19842564
161GRK70.18336081
162CAMKK10.17586717
163RPS6KA40.17349696
164ADRBK10.17030622
165IRAK10.16821593
166CAMK40.16126635
167* MAPK40.16110448

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.96512663
2* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049235.17224675
3PPAR signaling pathway_Homo sapiens_hsa033205.04052745
4DNA replication_Homo sapiens_hsa030304.25642042
5Fatty acid biosynthesis_Homo sapiens_hsa000613.85684335
6Glycerolipid metabolism_Homo sapiens_hsa005613.66800068
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.64004576
8Phenylalanine metabolism_Homo sapiens_hsa003603.55876511
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.38431967
10Thyroid cancer_Homo sapiens_hsa052163.14538907
11Protein export_Homo sapiens_hsa030603.10402498
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.92781106
13Sulfur relay system_Homo sapiens_hsa041222.88722860
14Fatty acid degradation_Homo sapiens_hsa000712.72497101
15Pyruvate metabolism_Homo sapiens_hsa006202.71073852
16Fatty acid metabolism_Homo sapiens_hsa012122.65860670
17RNA polymerase_Homo sapiens_hsa030202.50831789
18Homologous recombination_Homo sapiens_hsa034402.49232003
19Pyrimidine metabolism_Homo sapiens_hsa002402.46744439
20Adipocytokine signaling pathway_Homo sapiens_hsa049202.41322741
21beta-Alanine metabolism_Homo sapiens_hsa004102.37149840
22Propanoate metabolism_Homo sapiens_hsa006402.36841057
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.34196675
24Mismatch repair_Homo sapiens_hsa034302.31044472
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.22191975
26Base excision repair_Homo sapiens_hsa034102.21118939
27Tyrosine metabolism_Homo sapiens_hsa003502.16452875
28N-Glycan biosynthesis_Homo sapiens_hsa005102.03545052
29Fat digestion and absorption_Homo sapiens_hsa049751.98161465
30Histidine metabolism_Homo sapiens_hsa003401.94688258
31Primary immunodeficiency_Homo sapiens_hsa053401.80479821
32Nucleotide excision repair_Homo sapiens_hsa034201.78149699
33Spliceosome_Homo sapiens_hsa030401.75499203
34* AMPK signaling pathway_Homo sapiens_hsa041521.72249763
35Acute myeloid leukemia_Homo sapiens_hsa052211.71494547
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68946144
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.65427725
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.54272621
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51762015
40Tryptophan metabolism_Homo sapiens_hsa003801.51582409
41Hematopoietic cell lineage_Homo sapiens_hsa046401.48015512
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.46772830
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44472377
44Purine metabolism_Homo sapiens_hsa002301.40133129
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.39700763
46Folate biosynthesis_Homo sapiens_hsa007901.37405846
47Other glycan degradation_Homo sapiens_hsa005111.32581118
48Herpes simplex infection_Homo sapiens_hsa051681.29387538
49ECM-receptor interaction_Homo sapiens_hsa045121.22670650
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21196237
51Ovarian steroidogenesis_Homo sapiens_hsa049131.21186907
52Non-homologous end-joining_Homo sapiens_hsa034501.20265984
53Basal transcription factors_Homo sapiens_hsa030221.15400831
54Proteasome_Homo sapiens_hsa030501.14512047
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14292903
56Glycerophospholipid metabolism_Homo sapiens_hsa005641.13765479
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11858507
58Jak-STAT signaling pathway_Homo sapiens_hsa046301.10610868
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10480190
60Renin secretion_Homo sapiens_hsa049241.10386323
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10334869
62Measles_Homo sapiens_hsa051621.09534578
63p53 signaling pathway_Homo sapiens_hsa041151.08449898
64B cell receptor signaling pathway_Homo sapiens_hsa046621.07684166
65Fanconi anemia pathway_Homo sapiens_hsa034601.02830413
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96312748
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94093947
68Malaria_Homo sapiens_hsa051440.92669004
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91929502
70Insulin resistance_Homo sapiens_hsa049310.87838896
71Leishmaniasis_Homo sapiens_hsa051400.86619969
72* Insulin signaling pathway_Homo sapiens_hsa049100.86255513
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80941771
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.80325137
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79007948
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76443198
77Carbon metabolism_Homo sapiens_hsa012000.74960084
78Butanoate metabolism_Homo sapiens_hsa006500.74931395
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74704641
80One carbon pool by folate_Homo sapiens_hsa006700.74096827
81Cell cycle_Homo sapiens_hsa041100.73927148
82Focal adhesion_Homo sapiens_hsa045100.73334939
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.73036124
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71218818
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70661962
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.68330728
87RNA degradation_Homo sapiens_hsa030180.67282470
88* Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67002318
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.66190318
90Pentose phosphate pathway_Homo sapiens_hsa000300.64785185
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.64691749
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.63740042
93Type II diabetes mellitus_Homo sapiens_hsa049300.62265731
94Platelet activation_Homo sapiens_hsa046110.59189122
95Renin-angiotensin system_Homo sapiens_hsa046140.56928474
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56868858
97Antigen processing and presentation_Homo sapiens_hsa046120.56770194
98Lysine degradation_Homo sapiens_hsa003100.55945036
99Shigellosis_Homo sapiens_hsa051310.55617781
100Peroxisome_Homo sapiens_hsa041460.55513565
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55257207
102Pertussis_Homo sapiens_hsa051330.55100923
103Glucagon signaling pathway_Homo sapiens_hsa049220.54667238
104Systemic lupus erythematosus_Homo sapiens_hsa053220.53584285
105Allograft rejection_Homo sapiens_hsa053300.52793736
106Arachidonic acid metabolism_Homo sapiens_hsa005900.52737670
107Retinol metabolism_Homo sapiens_hsa008300.52711912
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52076510
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51649703
110Notch signaling pathway_Homo sapiens_hsa043300.51231930
111Caffeine metabolism_Homo sapiens_hsa002320.50796135
112Dorso-ventral axis formation_Homo sapiens_hsa043200.50679956
113Parkinsons disease_Homo sapiens_hsa050120.50185130
114RNA transport_Homo sapiens_hsa030130.49370108
115Epstein-Barr virus infection_Homo sapiens_hsa051690.48793303
116Dilated cardiomyopathy_Homo sapiens_hsa054140.48601398
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48533815
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45883044
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45772991
120Morphine addiction_Homo sapiens_hsa050320.43368769
121Hepatitis B_Homo sapiens_hsa051610.42942544
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42921420
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42833524
124Arginine biosynthesis_Homo sapiens_hsa002200.40680112
125Metabolic pathways_Homo sapiens_hsa011000.40450509
126ABC transporters_Homo sapiens_hsa020100.38925200
127Osteoclast differentiation_Homo sapiens_hsa043800.38822385
128Sulfur metabolism_Homo sapiens_hsa009200.37733382
129Oxidative phosphorylation_Homo sapiens_hsa001900.37726528
130Vitamin B6 metabolism_Homo sapiens_hsa007500.37603071
131Influenza A_Homo sapiens_hsa051640.36814295
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33751799
133Protein digestion and absorption_Homo sapiens_hsa049740.33639199
134Drug metabolism - other enzymes_Homo sapiens_hsa009830.33545273
135Regulation of autophagy_Homo sapiens_hsa041400.33136555
136Fatty acid elongation_Homo sapiens_hsa000620.32837524
137Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32818055
138Arginine and proline metabolism_Homo sapiens_hsa003300.32540611
139Sphingolipid metabolism_Homo sapiens_hsa006000.31630491
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31397566
141* cAMP signaling pathway_Homo sapiens_hsa040240.30033881
142Alcoholism_Homo sapiens_hsa050340.27633537
143Asthma_Homo sapiens_hsa053100.27097845
144Hepatitis C_Homo sapiens_hsa051600.26047798
145Bile secretion_Homo sapiens_hsa049760.25997209
146Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24655901
147Huntingtons disease_Homo sapiens_hsa050160.22766764
148Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22721070
149Cocaine addiction_Homo sapiens_hsa050300.22255110
150Chemical carcinogenesis_Homo sapiens_hsa052040.21203596
151Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20514181
152Melanogenesis_Homo sapiens_hsa049160.19594007
153Galactose metabolism_Homo sapiens_hsa000520.19321499
154Estrogen signaling pathway_Homo sapiens_hsa049150.18759238
155Rap1 signaling pathway_Homo sapiens_hsa040150.18508311
156Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18415929
157Toxoplasmosis_Homo sapiens_hsa051450.18132431
158Complement and coagulation cascades_Homo sapiens_hsa046100.18130785
159Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.18037681
160Colorectal cancer_Homo sapiens_hsa052100.17982098
161Salmonella infection_Homo sapiens_hsa051320.17364749
162Staphylococcus aureus infection_Homo sapiens_hsa051500.16877090
163GnRH signaling pathway_Homo sapiens_hsa049120.16381043
164Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16021099
165Pathways in cancer_Homo sapiens_hsa052000.15244825
166Circadian rhythm_Homo sapiens_hsa047100.14545133
167Proteoglycans in cancer_Homo sapiens_hsa052050.14122515
168Viral carcinogenesis_Homo sapiens_hsa052030.14064278
169FoxO signaling pathway_Homo sapiens_hsa040680.13971017
170Tuberculosis_Homo sapiens_hsa051520.13871106
171Legionellosis_Homo sapiens_hsa051340.13663082
172Leukocyte transendothelial migration_Homo sapiens_hsa046700.13196791
173Glutathione metabolism_Homo sapiens_hsa004800.12808016
174Vitamin digestion and absorption_Homo sapiens_hsa049770.12509753
175PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12454632
176AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.12260912
177Gap junction_Homo sapiens_hsa045400.10123380
178Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09798163
179Oxytocin signaling pathway_Homo sapiens_hsa049210.09407808
180Long-term potentiation_Homo sapiens_hsa047200.07908108
181Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.07407227
182Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07161150
183Ras signaling pathway_Homo sapiens_hsa040140.06376166
184Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.06161499
185Adherens junction_Homo sapiens_hsa045200.05884850

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