LIPF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sequestering of triglyceride (GO:0010889)9.81967350
2regulation of proton transport (GO:0010155)9.60293233
3peptide cross-linking (GO:0018149)9.51594191
4digestion (GO:0007586)9.17461057
5sarcoplasmic reticulum calcium ion transport (GO:0070296)8.85773279
6regulation of keratinocyte differentiation (GO:0045616)7.79625405
7low-density lipoprotein particle clearance (GO:0034383)7.75694443
8cellular response to zinc ion (GO:0071294)7.69026642
9triglyceride catabolic process (GO:0019433)7.18566739
10regulation of toll-like receptor 4 signaling pathway (GO:0034143)6.93656260
11response to vitamin A (GO:0033189)6.86949044
12regulation of relaxation of muscle (GO:1901077)6.65873742
13cobalamin metabolic process (GO:0009235)6.54576207
14neutral lipid catabolic process (GO:0046461)6.34772952
15acylglycerol catabolic process (GO:0046464)6.34772952
16biotin metabolic process (GO:0006768)6.30389019
17purine nucleotide salvage (GO:0032261)6.11832402
18muscle organ morphogenesis (GO:0048644)5.97614205
19diacylglycerol metabolic process (GO:0046339)5.93685781
20skeletal muscle contraction (GO:0003009)5.85175608
21lipid storage (GO:0019915)5.77989342
22long-chain fatty acid biosynthetic process (GO:0042759)5.69865742
23pH reduction (GO:0045851)5.69686187
24potassium ion export (GO:0071435)5.66552387
25regulation of skeletal muscle contraction (GO:0014819)5.64434476
26keratinocyte differentiation (GO:0030216)5.63687310
27fatty acid homeostasis (GO:0055089)5.60962428
28regulation of cardioblast proliferation (GO:0003264)5.58035562
29regulation of secondary heart field cardioblast proliferation (GO:0003266)5.58035562
30muscle filament sliding (GO:0030049)5.47106765
31actin-myosin filament sliding (GO:0033275)5.47106765
32regulation of skeletal muscle cell differentiation (GO:2001014)5.42841951
33vitamin transport (GO:0051180)5.39280119
34coronary vasculature morphogenesis (GO:0060977)5.30159511
35outer ear morphogenesis (GO:0042473)5.21200567
36innate immune response in mucosa (GO:0002227)5.15257781
37linoleic acid metabolic process (GO:0043651)5.09798607
38tooth mineralization (GO:0034505)5.08120670
39lipid particle organization (GO:0034389)5.00302763
40CDP-diacylglycerol biosynthetic process (GO:0016024)4.97134487
41regulation of triglyceride catabolic process (GO:0010896)4.96757227
42lymph vessel development (GO:0001945)4.78176892
43cellular response to epidermal growth factor stimulus (GO:0071364)4.77070367
44CDP-diacylglycerol metabolic process (GO:0046341)4.76833609
45regulation of epidermal cell differentiation (GO:0045604)4.69316253
46cellular response to cadmium ion (GO:0071276)4.67655692
47cellular response to retinoic acid (GO:0071300)4.64666108
48protein autoprocessing (GO:0016540)4.61352032
49negative regulation of toll-like receptor signaling pathway (GO:0034122)4.48227027
50actin-mediated cell contraction (GO:0070252)4.41144112
51glycerolipid catabolic process (GO:0046503)4.40618418
52white fat cell differentiation (GO:0050872)4.40370192
53mucosal-associated lymphoid tissue development (GO:0048537)4.35888899
54Peyers patch development (GO:0048541)4.35888899
55positive regulation of lipid storage (GO:0010884)4.33464936
56skeletal muscle organ development (GO:0060538)4.27217787
57triglyceride biosynthetic process (GO:0019432)4.26113798
58tongue development (GO:0043586)4.16873811
59protein heterotrimerization (GO:0070208)4.14747139
60negative regulation of thymocyte apoptotic process (GO:0070244)4.12970161
61lung secretory cell differentiation (GO:0061140)4.09328290
62acylglycerol biosynthetic process (GO:0046463)4.08461415
63neutral lipid biosynthetic process (GO:0046460)4.08461415
64muscle cell fate commitment (GO:0042693)4.07757869
65creatine metabolic process (GO:0006600)4.05890635
66regulation of penile erection (GO:0060405)4.04389853
67mucosal immune response (GO:0002385)4.01256853
68lung vasculature development (GO:0060426)4.00156644
69cellular response to glucocorticoid stimulus (GO:0071385)3.91936593
70positive regulation of glomerulus development (GO:0090193)3.91255505
71response to epidermal growth factor (GO:0070849)3.90947529
72negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.90902828
73negative regulation of calcium ion transmembrane transport (GO:1903170)3.90902828
74histamine secretion (GO:0001821)3.89892974
75embryonic viscerocranium morphogenesis (GO:0048703)3.86934221
76epidermal cell differentiation (GO:0009913)3.86229165
77fatty-acyl-CoA biosynthetic process (GO:0046949)3.86097284
78organ or tissue specific immune response (GO:0002251)3.79342496
79cellular response to corticosteroid stimulus (GO:0071384)3.77656675
80ethanol oxidation (GO:0006069)3.73325981
81lipoxygenase pathway (GO:0019372)3.71387194
82plasma membrane repair (GO:0001778)3.70933924
83positive regulation of myotube differentiation (GO:0010831)3.68837504
84negative regulation of lipid catabolic process (GO:0050995)3.67463610
85fatty-acyl-CoA metabolic process (GO:0035337)3.65412885
86membrane repolarization during action potential (GO:0086011)3.64340058
87negative regulation of execution phase of apoptosis (GO:1900118)3.62650600
88regulation of lipid storage (GO:0010883)3.61002180
89mature B cell differentiation involved in immune response (GO:0002313)3.59400255
90positive regulation of triglyceride metabolic process (GO:0090208)3.56941431
91tricarboxylic acid cycle (GO:0006099)3.54087901
92establishment of skin barrier (GO:0061436)3.52236630
93thioester biosynthetic process (GO:0035384)3.51387324
94acyl-CoA biosynthetic process (GO:0071616)3.51387324
95positive regulation of protein depolymerization (GO:1901881)3.47902080
96cranial nerve morphogenesis (GO:0021602)3.47063041
97negative regulation of lipid storage (GO:0010888)3.44257733
98positive regulation of pseudopodium assembly (GO:0031274)3.43787801
99response to vitamin E (GO:0033197)3.43016719
100ATP hydrolysis coupled proton transport (GO:0015991)3.42772452
101energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.42772452
102actin filament-based movement (GO:0030048)3.40836352
103cellular response to epinephrine stimulus (GO:0071872)3.39547986
104striated muscle contraction (GO:0006941)3.39462694
105positive regulation of lipid catabolic process (GO:0050996)3.39230793
106negative regulation of norepinephrine secretion (GO:0010700)3.38706572
107myotube differentiation (GO:0014902)3.36896295
108positive regulation of p38MAPK cascade (GO:1900745)3.36090334
109regulation of transforming growth factor beta2 production (GO:0032909)3.34963659
110negative regulation of smooth muscle cell proliferation (GO:0048662)3.33406405
111negative regulation of granulocyte differentiation (GO:0030853)3.32887392
112acetyl-CoA metabolic process (GO:0006084)3.30915428
113regulation of lipid catabolic process (GO:0050994)3.30843033
114extracellular matrix assembly (GO:0085029)3.28114682
115* triglyceride metabolic process (GO:0006641)3.27969111
116regulation of germinal center formation (GO:0002634)3.27842751
117L-serine transport (GO:0015825)3.25618421
118regulation of epidermis development (GO:0045682)3.25483244
119negative regulation of B cell apoptotic process (GO:0002903)3.24944158
120positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.22082028
121diaphragm development (GO:0060539)3.21831538
122regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.21026511
123response to phenylpropanoid (GO:0080184)3.18911447
124regulation of water loss via skin (GO:0033561)3.17952776
125positive regulation of skeletal muscle tissue development (GO:0048643)3.17448739
126positive regulation of T cell differentiation in thymus (GO:0033089)3.15870333
127negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.14035728
128membrane repolarization (GO:0086009)3.13258164
129* acylglycerol metabolic process (GO:0006639)3.13099343
130cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.12246457
131positive regulation of metanephros development (GO:0072216)3.10699835
132myofibril assembly (GO:0030239)3.09157573
133regulation of pH (GO:0006885)3.08287753
134* neutral lipid metabolic process (GO:0006638)3.07872150
135desmosome organization (GO:0002934)3.07667636
136positive regulation of fatty acid beta-oxidation (GO:0032000)3.07000698
137brown fat cell differentiation (GO:0050873)3.06780371
138regulation of pseudopodium assembly (GO:0031272)3.05343886
139regulation of glycogen (starch) synthase activity (GO:2000465)3.04871965
140long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.04811970
141extracellular fibril organization (GO:0043206)3.04642447
142retina vasculature morphogenesis in camera-type eye (GO:0061299)3.03962208
143bundle of His cell to Purkinje myocyte communication (GO:0086069)3.02220462
144ovulation cycle (GO:0042698)3.00996230
145phosphatidic acid metabolic process (GO:0046473)3.00570997
146phosphatidic acid biosynthetic process (GO:0006654)3.00570997
147sarcomere organization (GO:0045214)3.00510188
148keratinization (GO:0031424)20.4652880
149valine metabolic process (GO:0006573)2.99321464
150histamine transport (GO:0051608)2.98986475
151purine nucleobase biosynthetic process (GO:0009113)2.98982912
152negative regulation of smooth muscle cell migration (GO:0014912)2.98203487
153nucleotide salvage (GO:0043173)2.96902623
154response to muscle activity (GO:0014850)2.93464308
155basement membrane organization (GO:0071711)2.91865885
156cAMP biosynthetic process (GO:0006171)2.91087097
157negative regulation of protein autophosphorylation (GO:0031953)2.91031905
158vascular endothelial growth factor signaling pathway (GO:0038084)2.90106675
159skeletal muscle fiber development (GO:0048741)2.89011522
160vitamin transmembrane transport (GO:0035461)2.88146637
161serine transport (GO:0032329)2.86711699
162adenosine metabolic process (GO:0046085)2.86692610
163response to dietary excess (GO:0002021)2.84347027
164keratan sulfate catabolic process (GO:0042340)2.82536425
165fibril organization (GO:0097435)2.81490709
166carnitine shuttle (GO:0006853)2.81376569
167negative regulation of gluconeogenesis (GO:0045721)2.81291576
168positive regulation of fatty acid oxidation (GO:0046321)2.81172517
169regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.81043514
170regulation of p38MAPK cascade (GO:1900744)2.80766047
171aspartate family amino acid catabolic process (GO:0009068)2.80594614
172regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.79922801
173regulation of calcium ion transmembrane transporter activity (GO:1901019)2.79903430
174regulation of calcium ion transmembrane transport (GO:1903169)2.79903430
175skeletal muscle adaptation (GO:0043501)2.78918012
176regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.78080789
177regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.77532626
178plasma lipoprotein particle clearance (GO:0034381)2.77093267
179purine deoxyribonucleotide catabolic process (GO:0009155)2.76394119
180regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.73995036
181NADH metabolic process (GO:0006734)2.69847838
182pharyngeal system development (GO:0060037)2.69119266
183mature B cell differentiation (GO:0002335)2.64002532
184positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.62936917
185otic vesicle formation (GO:0030916)2.62886780
1862-oxoglutarate metabolic process (GO:0006103)2.62801973
187oxaloacetate metabolic process (GO:0006107)2.62592812
188muscle contraction (GO:0006936)2.60697524
189fatty acid transmembrane transport (GO:1902001)2.60160577
190negative regulation of circadian rhythm (GO:0042754)2.60036655
191regulation of acyl-CoA biosynthetic process (GO:0050812)2.59707545
192negative regulation of ion transmembrane transporter activity (GO:0032413)2.59372736
193outflow tract septum morphogenesis (GO:0003148)2.57166653
194cell wall macromolecule catabolic process (GO:0016998)14.8536800
195cell wall macromolecule metabolic process (GO:0044036)14.8536800
196negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)13.6117090

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF652_21678463_ChIP-ChIP_ZR75-1_Human8.73017328
2TP63_17297297_ChIP-ChIP_HaCaT_Human8.64966125
3IGF1R_20145208_ChIP-Seq_DFB_Human5.21169599
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.07570760
5HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse3.34102429
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.09662802
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.05772141
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.00026849
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.49722305
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.44343433
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.32570512
12CTCF_27219007_Chip-Seq_Bcells_Human2.27059721
13SRY_22984422_ChIP-ChIP_TESTIS_Rat2.27014454
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.23152169
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.22797426
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18698561
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.12719942
18CTCF_20526341_ChIP-Seq_ESCs_Human2.11135641
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97943130
20EGR1_19374776_ChIP-ChIP_THP-1_Human1.88822302
21ERG_20517297_ChIP-Seq_VCAP_Human1.84569384
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.71828045
23ZNF263_19887448_ChIP-Seq_K562_Human1.70573011
24VDR_22108803_ChIP-Seq_LS180_Human1.66555948
25SOX2_27498859_Chip-Seq_STOMACH_Mouse1.66510424
26RXR_22158963_ChIP-Seq_LIVER_Mouse1.57707357
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.55939660
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55646540
29CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.54047704
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.51614019
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.51614019
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.51614019
33CLOCK_20551151_ChIP-Seq_293T_Human1.49840052
34BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.48944960
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46638218
36P63_26484246_Chip-Seq_KERATINOCYTES_Human1.46257743
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46145103
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.45878280
39RACK7_27058665_Chip-Seq_MCF-7_Human1.45788707
40AHR_22903824_ChIP-Seq_MCF-7_Human1.44175940
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.42614370
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41211092
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40654305
44GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.34755914
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.32366376
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30047849
47BCOR_27268052_Chip-Seq_Bcells_Human1.27688676
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27591494
49SA1_22415368_ChIP-Seq_MEFs_Mouse1.27383878
50PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.26764775
51EGR1_19032775_ChIP-ChIP_M12_Human1.25584698
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.25474019
53GATA6_21074721_ChIP-Seq_CACO-2_Human1.24372927
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.24138011
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23868136
56SMC3_22415368_ChIP-Seq_MEFs_Mouse1.23126721
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23035711
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21837040
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21658940
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20723905
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20609145
62FOXH1_21741376_ChIP-Seq_ESCs_Human1.20076988
63NANOG_20526341_ChIP-Seq_ESCs_Human1.19417567
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19298216
65CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19052357
66SMC1_22415368_ChIP-Seq_MEFs_Mouse1.18977227
67KDM2B_26808549_Chip-Seq_K562_Human1.18605173
68KLF5_25053715_ChIP-Seq_YYC3_Human1.17828623
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.17053135
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14849084
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14552710
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14289185
73ISL1_27105846_Chip-Seq_CPCs_Mouse1.14198106
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14159452
75LXR_22292898_ChIP-Seq_THP-1_Human1.13831709
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13063786
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12152102
78PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.11856590
79RXR_22108803_ChIP-Seq_LS180_Human1.10907205
80TBX20_22328084_ChIP-Seq_HEART_Mouse1.10873132
81TBX20_22080862_ChIP-Seq_HEART_Mouse1.10873132
82SMC4_20622854_ChIP-Seq_HELA_Human1.10725297
83LXR_22158963_ChIP-Seq_LIVER_Mouse1.09906698
84KDM2B_26808549_Chip-Seq_DND41_Human1.09429682
85ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08734930
86OCT1_27270436_Chip-Seq_PROSTATE_Human1.08440135
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08340017
88P68_20966046_ChIP-Seq_HELA_Human1.08171849
89RNF2_27304074_Chip-Seq_ESCs_Mouse1.08032387
90HTT_18923047_ChIP-ChIP_STHdh_Human1.06734168
91SOX2_20726797_ChIP-Seq_SW620_Human1.06717051
92YY1_22570637_ChIP-Seq_MALME-3M_Human1.06624646
93EZH2_27304074_Chip-Seq_ESCs_Mouse1.06576230
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06528161
95ERG_21242973_ChIP-ChIP_JURKAT_Human1.06321990
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05475835
97SA1_27219007_Chip-Seq_ERYTHROID_Human1.05165467
98CDX2_20551321_ChIP-Seq_CACO-2_Human1.05133426
99CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04822313
100NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04770268
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04121172
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03689226
103CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03620589
104EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03325863
105ELK4_26923725_Chip-Seq_MESODERM_Mouse1.02288813
106BP1_19119308_ChIP-ChIP_Hs578T_Human1.02100947
107SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01162804
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98898880
109GATA3_24758297_ChIP-Seq_MCF-7_Human0.98323126
110EP300_21415370_ChIP-Seq_HL-1_Mouse0.96899499
111GATA1_22025678_ChIP-Seq_K562_Human0.96537978
112SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96250756
113SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96250756
114SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96225426
115HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95621727
116KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95146603
117SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94732795
118SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94598890
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94392437
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94171624
121CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93635453
122EZH2_22144423_ChIP-Seq_EOC_Human0.93616031
123PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93430903
124BCL6_27268052_Chip-Seq_Bcells_Human0.93319850
125ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93022621
126KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91914693
127RARB_27405468_Chip-Seq_BRAIN_Mouse0.91726962
128MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.91412213
129WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90951868
130MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90645679
131EZH2_27294783_Chip-Seq_ESCs_Mouse0.90557391
132* CJUN_26792858_Chip-Seq_BT549_Human0.90313071
133KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89974726
134RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89349796
135ELK3_25401928_ChIP-Seq_HUVEC_Human0.89294993
136ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89246933
137GATA2_21666600_ChIP-Seq_HMVEC_Human0.89104553
138PIAS1_25552417_ChIP-Seq_VCAP_Human0.88454513
139GBX2_23144817_ChIP-Seq_PC3_Human0.88224877
140PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88073970
141RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87400701
142TP63_22573176_ChIP-Seq_HFKS_Human0.86655315
143PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85003909
144RUNX1_27514584_Chip-Seq_MCF-7_Human0.84784062
145JARID2_20075857_ChIP-Seq_MESCs_Mouse0.84334944
146P53_21459846_ChIP-Seq_SAOS-2_Human0.83540752
147PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83027605
148SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.82920310
149GATA3_21878914_ChIP-Seq_MCF-7_Human0.82801516
150IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82762554
151ERA_21632823_ChIP-Seq_H3396_Human0.82335236
152EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81401346
153RAC3_21632823_ChIP-Seq_H3396_Human0.81357940
154EZH2_18974828_ChIP-Seq_MESCs_Mouse0.80435484
155RNF2_18974828_ChIP-Seq_MESCs_Mouse0.80435484
156UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.80357217
157EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.80112597
158TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78728047
159CEBPB_22108803_ChIP-Seq_LS180_Human0.78659750
160TP53_20018659_ChIP-ChIP_R1E_Mouse0.78627225
161CSB_26484114_Chip-Seq_FIBROBLAST_Human0.76977732

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002234_abnormal_pharynx_morphology5.42606843
2MP0000751_myopathy4.99132860
3MP0002796_impaired_skin_barrier4.90625520
4MP0003646_muscle_fatigue4.83147749
5MP0005275_abnormal_skin_tensile4.30555311
6MP0000749_muscle_degeneration3.93191944
7MP0000467_abnormal_esophagus_morphology3.70707555
8MP0005670_abnormal_white_adipose3.56656995
9MP0002837_dystrophic_cardiac_calcinosis3.42502620
10MP0000762_abnormal_tongue_morphology3.23087378
11MP0004145_abnormal_muscle_electrophysio2.96815063
12MP0009697_abnormal_copulation2.84442500
13MP0005083_abnormal_biliary_tract2.84074761
14MP0001664_abnormal_digestion2.83490320
15MP0000747_muscle_weakness2.78977348
16MP0005501_abnormal_skin_physiology2.69924577
17MP0000759_abnormal_skeletal_muscle2.54078339
18MP0002106_abnormal_muscle_physiology2.49456813
19MP0004130_abnormal_muscle_cell2.35242403
20MP0000678_abnormal_parathyroid_gland2.34938673
21MP0004185_abnormal_adipocyte_glucose2.26869297
22MP0002095_abnormal_skin_pigmentation2.19208465
23MP0003252_abnormal_bile_duct2.19144505
24MP0008438_abnormal_cutaneous_collagen2.17086920
25MP0001243_abnormal_dermal_layer2.15232851
26MP0004087_abnormal_muscle_fiber2.12260825
27MP0004036_abnormal_muscle_relaxation2.04802531
28MP0000750_abnormal_muscle_regeneration2.04561149
29MP0005369_muscle_phenotype2.01684285
30MP0008004_abnormal_stomach_pH17.1435208
31MP0010234_abnormal_vibrissa_follicle1.94200844
32MP0000733_abnormal_muscle_development1.92141479
33MP0000371_diluted_coat_color1.85705084
34MP0002269_muscular_atrophy1.83226250
35MP0003705_abnormal_hypodermis_morpholog1.75339868
36MP0005620_abnormal_muscle_contractility1.74823855
37MP0002332_abnormal_exercise_endurance1.65266696
38MP0005666_abnormal_adipose_tissue1.64451737
39MP0005503_abnormal_tendon_morphology1.52739434
40MP0002249_abnormal_larynx_morphology1.51354684
41MP0004270_analgesia1.51146575
42MP0001879_abnormal_lymphatic_vessel1.48944440
43MP0005330_cardiomyopathy1.47015139
44MP0006036_abnormal_mitochondrial_physio1.45141450
45MP0003806_abnormal_nucleotide_metabolis1.42073480
46MP0005535_abnormal_body_temperature1.40906949
47MP0005266_abnormal_metabolism1.33561940
48MP0002970_abnormal_white_adipose1.32579030
49MP0005334_abnormal_fat_pad1.29085075
50MP0002972_abnormal_cardiac_muscle1.26146845
51MP0002127_abnormal_cardiovascular_syste1.25637899
52MP0000470_abnormal_stomach_morphology1.22506382
53MP0004084_abnormal_cardiac_muscle1.22300868
54MP0004272_abnormal_basement_membrane1.20824129
55MP0010368_abnormal_lymphatic_system1.20022094
56MP0010771_integument_phenotype1.11310497
57MP0003724_increased_susceptibility_to1.10179297
58MP0005375_adipose_tissue_phenotype1.09940405
59MP0001216_abnormal_epidermal_layer1.07873042
60MP0009115_abnormal_fat_cell1.07289044
61MP0004947_skin_inflammation1.04588821
62MP0003283_abnormal_digestive_organ1.04284361
63MP0004233_abnormal_muscle_weight1.04005778
64MP0000579_abnormal_nail_morphology0.99042357
65MP0003959_abnormal_lean_body0.98974479
66MP0001958_emphysema0.96587643
67MP0002254_reproductive_system_inflammat0.95958345
68MP0005448_abnormal_energy_balance0.94145337
69MP0002075_abnormal_coat/hair_pigmentati0.92042051
70MP0004215_abnormal_myocardial_fiber0.90865516
71MP0004484_altered_response_of0.90724151
72MP0003950_abnormal_plasma_membrane0.89255023
73MP0002139_abnormal_hepatobiliary_system0.87304729
74MP0005595_abnormal_vascular_smooth0.86719827
75MP0002971_abnormal_brown_adipose0.85972264
76MP0000647_abnormal_sebaceous_gland0.84619780
77MP0000767_abnormal_smooth_muscle0.84161150
78MP0009780_abnormal_chondrocyte_physiolo0.82170597
79MP0003221_abnormal_cardiomyocyte_apopto0.82140988
80MP0000566_synostosis0.81288120
81MP0003656_abnormal_erythrocyte_physiolo0.80350850
82MP0002108_abnormal_muscle_morphology0.80128675
83MP0001544_abnormal_cardiovascular_syste0.80029159
84MP0005385_cardiovascular_system_phenoty0.80029159
85MP0000049_abnormal_middle_ear0.78577070
86MP0005365_abnormal_bile_salt0.78545831
87MP0003828_pulmonary_edema0.78446810
88MP0004043_abnormal_pH_regulation0.78037317
89MP0005084_abnormal_gallbladder_morpholo0.75742745
90MP0002118_abnormal_lipid_homeostasis0.75595736
91MP0000003_abnormal_adipose_tissue0.74655485
92MP0001191_abnormal_skin_condition0.74448760
93MP0003953_abnormal_hormone_level0.73856054
94MP0010630_abnormal_cardiac_muscle0.72244266
95MP0008961_abnormal_basal_metabolism0.70938022
96MP0001299_abnormal_eye_distance/0.70766975
97MP0003329_amyloid_beta_deposits0.69804288
98MP0002295_abnormal_pulmonary_circulatio0.69649583
99MP0000462_abnormal_digestive_system0.69209209
100MP0002909_abnormal_adrenal_gland0.68946747
101MP0005647_abnormal_sex_gland0.68464353
102MP0005452_abnormal_adipose_tissue0.68288178
103MP0003948_abnormal_gas_homeostasis0.67590775
104MP0009278_abnormal_bone_marrow0.67008808
105MP0001661_extended_life_span0.66362671
106MP0003566_abnormal_cell_adhesion0.65150588
107MP0003453_abnormal_keratinocyte_physiol0.64072227
108MP0005451_abnormal_body_composition0.64063138
109MP0005085_abnormal_gallbladder_physiolo0.63636501
110MP0000367_abnormal_coat/_hair0.62699915
111MP0000372_irregular_coat_pigmentation0.62393623
112MP0009931_abnormal_skin_appearance0.62231407
113MP0006138_congestive_heart_failure0.61711751
114MP0001177_atelectasis0.60062124
115MP0003303_peritoneal_inflammation0.59896137
116MP0000427_abnormal_hair_cycle0.57753943
117MP0008569_lethality_at_weaning0.57329907
118MP0002078_abnormal_glucose_homeostasis0.57095641
119MP0004858_abnormal_nervous_system0.56989633
120MP0003279_aneurysm0.56675586
121MP0003943_abnormal_hepatobiliary_system0.56419010
122MP0009672_abnormal_birth_weight0.56386254
123MP0000681_abnormal_thyroid_gland0.56195620
124MP0003868_abnormal_feces_composition0.56005092
125MP0008775_abnormal_heart_ventricle0.55285447
126MP0000534_abnormal_ureter_morphology0.55234981
127MP0005360_urolithiasis0.54991051
128MP0000013_abnormal_adipose_tissue0.54587511
129MP0010329_abnormal_lipoprotein_level0.54358382
130MP0009250_abnormal_appendicular_skeleto0.53243233
131MP0000343_altered_response_to0.52748956
132MP0005508_abnormal_skeleton_morphology0.52530404
133MP0001186_pigmentation_phenotype0.52317296
134MP0005319_abnormal_enzyme/_coenzyme0.52121150
135MP0009703_decreased_birth_body0.52075694
136MP0004859_abnormal_synaptic_plasticity0.52060085
137MP0000230_abnormal_systemic_arterial0.50440418
138MP0002060_abnormal_skin_morphology0.50231670
139MP0008875_abnormal_xenobiotic_pharmacok0.49488628
140MP0003075_altered_response_to0.49186744
141MP0003191_abnormal_cellular_cholesterol0.48547480
142MP0003137_abnormal_impulse_conducting0.48333968
143MP0000477_abnormal_intestine_morphology0.47317080
144MP0009840_abnormal_foam_cell0.45841355
145MP0003195_calcinosis0.44631187
146MP0005164_abnormal_response_to0.44133174
147MP0005076_abnormal_cell_differentiation0.44075519
148MP0005167_abnormal_blood-brain_barrier0.43970483
149MP0000249_abnormal_blood_vessel0.42016010
150MP0002896_abnormal_bone_mineralization0.41545397
151MP0002876_abnormal_thyroid_physiology0.40009520
152MP0001944_abnormal_pancreas_morphology0.39620005
153MP0005381_digestive/alimentary_phenotyp0.39110955
154MP0003942_abnormal_urinary_system0.38823956
155MP0002009_preneoplasia0.37303238
156MP0005645_abnormal_hypothalamus_physiol0.36194458
157MP0002128_abnormal_blood_circulation0.35889265
158MP0002933_joint_inflammation0.35614579
159MP0001614_abnormal_blood_vessel0.35414755
160MP0005409_darkened_coat_color0.35259207
161MP0004134_abnormal_chest_morphology0.34525238
162MP0005397_hematopoietic_system_phenotyp0.33804290
163MP0001545_abnormal_hematopoietic_system0.33804290
164MP0000609_abnormal_liver_physiology0.33465335
165MP0005165_increased_susceptibility_to0.33426919
166MP0001849_ear_inflammation0.32883106
167MP0002998_abnormal_bone_remodeling0.32880936

Predicted human phenotypes

RankGene SetZ-score
1Megaloblastic anemia (HP:0001889)7.98933860
2Abnormality of the vitamin B12 metabolism (HP:0004341)7.97378319
3Abnormality of vitamin B metabolism (HP:0004340)7.43573766
4Distal arthrogryposis (HP:0005684)6.51689017
5Exercise-induced myalgia (HP:0003738)6.38058206
6Muscle fiber inclusion bodies (HP:0100299)6.34540281
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.32723009
8Abnormality of vitamin metabolism (HP:0100508)6.03692620
9Nemaline bodies (HP:0003798)5.67502872
10Round ear (HP:0100830)5.42484555
11Ulnar deviation of the wrist (HP:0003049)5.16460532
12Exercise-induced muscle cramps (HP:0003710)5.00761580
13Muscle hypertrophy of the lower extremities (HP:0008968)4.91364604
14Increased connective tissue (HP:0009025)4.87021362
15Type 1 muscle fiber predominance (HP:0003803)4.87006132
16Difficulty running (HP:0009046)4.78994775
17Calf muscle hypertrophy (HP:0008981)4.76635425
18Aortic aneurysm (HP:0004942)4.67633506
19Absent phalangeal crease (HP:0006109)4.64726327
20Myopathic facies (HP:0002058)4.56997646
21Acanthosis nigricans (HP:0000956)4.53010061
22Hypertriglyceridemia (HP:0002155)4.51968740
23Calcaneovalgus deformity (HP:0001848)4.49529738
24Myoglobinuria (HP:0002913)4.47109652
25Autoimmune thrombocytopenia (HP:0001973)4.23889368
26Muscle fiber splitting (HP:0003555)4.20046988
27Hyporeflexia of lower limbs (HP:0002600)4.12235806
28Ventricular fibrillation (HP:0001663)4.09305042
29Unilateral renal agenesis (HP:0000122)4.05933884
30Increased IgE level (HP:0003212)4.03687712
31Aortic dissection (HP:0002647)3.99343879
32Deformed tarsal bones (HP:0008119)3.98241819
33Long foot (HP:0001833)3.97944692
34Oligomenorrhea (HP:0000876)3.97046996
35Rimmed vacuoles (HP:0003805)3.88260056
36Abnormal finger flexion creases (HP:0006143)3.85598470
37Increased variability in muscle fiber diameter (HP:0003557)3.70824745
38Mesangial abnormality (HP:0001966)3.59066780
39Lymphangioma (HP:0100764)3.55066819
40Double outlet right ventricle (HP:0001719)3.52904043
41Congenital malformation of the right heart (HP:0011723)3.52904043
42Abnormality of skeletal muscle fiber size (HP:0012084)3.51218050
43Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.42540242
44Macrocytic anemia (HP:0001972)3.40434652
45Growth hormone excess (HP:0000845)3.37678650
46Autoimmune hemolytic anemia (HP:0001890)3.33797317
47Right ventricular cardiomyopathy (HP:0011663)3.22797445
48Abnormality of the calf musculature (HP:0001430)3.21945676
49Distal lower limb muscle weakness (HP:0009053)3.19663943
50Abnormality of the aortic arch (HP:0012303)3.17822121
51Insulin-resistant diabetes mellitus (HP:0000831)3.15916887
52Abnormality of the parathyroid morphology (HP:0011766)3.14123264
53EMG: myopathic abnormalities (HP:0003458)3.12566585
54Cerebral aneurysm (HP:0004944)3.10268612
55Cholelithiasis (HP:0001081)3.09512236
56Muscle stiffness (HP:0003552)3.06082511
57Insulin resistance (HP:0000855)3.04544458
58Congenital ichthyosiform erythroderma (HP:0007431)3.03691098
59Myotonia (HP:0002486)3.03428578
60Neoplasm of the heart (HP:0100544)3.00900352
61Paralysis (HP:0003470)3.00306326
62Areflexia of lower limbs (HP:0002522)2.98836084
63Hyperthyroidism (HP:0000836)2.94739478
64Bone cyst (HP:0012062)2.94606660
65Protrusio acetabuli (HP:0003179)2.90799621
66Rhabdomyolysis (HP:0003201)2.90692738
67Distal lower limb amyotrophy (HP:0008944)2.90551596
68Abnormal pancreas size (HP:0012094)2.89860794
69Abnormal gallbladder morphology (HP:0012437)2.82354287
70Short 4th metacarpal (HP:0010044)2.81545004
71Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.81545004
72Cupped ribs (HP:0000887)2.77053928
73Difficulty climbing stairs (HP:0003551)2.75775666
74Abnormality of the calcaneus (HP:0008364)2.75048861
75Abnormality of B cell number (HP:0010975)2.72286332
76B lymphocytopenia (HP:0010976)2.72286332
77Neck muscle weakness (HP:0000467)2.67419458
78Facial diplegia (HP:0001349)2.60453318
79Frequent falls (HP:0002359)2.46097995
80Premature rupture of membranes (HP:0001788)2.44606550
81Patent foramen ovale (HP:0001655)2.39059222
82Axonal loss (HP:0003447)2.38363973
83Infantile muscular hypotonia (HP:0008947)2.38246518
84Hypoplastic ischia (HP:0003175)2.37408050
85Lower limb amyotrophy (HP:0007210)2.33145771
86Hypoplastic left heart (HP:0004383)2.30383953
87Tetany (HP:0001281)2.26440334
88Short palpebral fissure (HP:0012745)2.26066342
89Polyphagia (HP:0002591)2.19469000
90Increased muscle lipid content (HP:0009058)2.18727663
91Prominent supraorbital ridges (HP:0000336)2.10707647
92Aneurysm (HP:0002617)2.09608407
93Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.08960804
94Thyroiditis (HP:0100646)2.06915703
95Abnormality of the ischium (HP:0003174)2.06177689
96Shoulder girdle muscle weakness (HP:0003547)2.04741955
97Amblyopia (HP:0000646)2.04530133
98Hemorrhage of the eye (HP:0011885)2.03574206
99Pulmonary artery stenosis (HP:0004415)2.03091632
100Visceral angiomatosis (HP:0100761)2.02468595
101Scapular winging (HP:0003691)2.01203508
102Abnormal number of erythroid precursors (HP:0012131)14.9509815
103Abnormality of cells of the erythroid lineage (HP:0012130)13.5076253
104Oral leukoplakia (HP:0002745)11.5182067
105Pelvic girdle muscle weakness (HP:0003749)1.98959758
106Severe combined immunodeficiency (HP:0004430)1.97263627
107Complement deficiency (HP:0004431)1.95067649
108Paresthesia (HP:0003401)1.93921287
109Delusions (HP:0000746)1.93012685
110Aortic regurgitation (HP:0001659)1.92897540
111Easy fatigability (HP:0003388)1.92195793
112Foot dorsiflexor weakness (HP:0009027)1.91907010
113Turricephaly (HP:0000262)1.91637830
114Abnormality of the musculature of the pelvis (HP:0001469)1.91322526
115Abnormality of the hip-girdle musculature (HP:0001445)1.91322526
116Seborrheic dermatitis (HP:0001051)1.90274404
117Prolonged QT interval (HP:0001657)1.89749115
118Hyperkalemia (HP:0002153)1.88645912
119Abnormality of the 4th metacarpal (HP:0010012)1.88246456
120Hypertensive crisis (HP:0100735)1.87565759
121Dilatation of the ascending aorta (HP:0005111)1.86804939
122Nasal speech (HP:0001611)1.86736382
123Accelerated skeletal maturation (HP:0005616)1.86716967
124Muscular dystrophy (HP:0003560)1.85271514
125Ulnar deviation of finger (HP:0009465)1.85151309
126Large hands (HP:0001176)1.84327981
127Exotropia (HP:0000577)1.83628915
128Hemangiomatosis (HP:0007461)1.83006924
129Achilles tendon contracture (HP:0001771)1.82883418
130Ectropion (HP:0000656)1.82343444
131Mitral valve prolapse (HP:0001634)1.80976280
132Abnormality of the gallbladder (HP:0005264)1.80436782
133Abnormality of the Achilles tendon (HP:0005109)1.75775042
134Gout (HP:0001997)1.74585648
135Abnormality of the foot musculature (HP:0001436)1.73452474
136Abnormality of complement system (HP:0005339)1.73329942
137Aplasia involving bones of the upper limbs (HP:0009823)1.73245912
138Aplasia of the phalanges of the hand (HP:0009802)1.73245912
139Aplasia involving bones of the extremities (HP:0009825)1.73245912
140Cervical subluxation (HP:0003308)1.72933612
141Broad metatarsal (HP:0001783)1.72385883
142Abnormality of the periventricular white matter (HP:0002518)1.71416337
143Abnormal umbilical cord blood vessels (HP:0011403)1.71021917
144Single umbilical artery (HP:0001195)1.71021917
145Abnormality of the fetal cardiovascular system (HP:0010948)1.71021917
146Shallow orbits (HP:0000586)1.70625054
147Wrist flexion contracture (HP:0001239)1.70380214
148Bronchomalacia (HP:0002780)1.69500430
149Abnormality of carpal bone ossification (HP:0006257)1.68342564
150Corneal erosion (HP:0200020)1.67918378
151Metatarsus adductus (HP:0001840)1.67371117
152Palmoplantar keratoderma (HP:0000982)1.66205035
153Rectal prolapse (HP:0002035)1.66112580
154Abnormality of the shoulder girdle musculature (HP:0001435)1.65964241
155Hypoplastic heart (HP:0001961)1.65905775
156Woolly hair (HP:0002224)1.65836919
157Abnormal ossification of hand bones (HP:0005921)1.65459011
158Malnutrition (HP:0004395)1.65247290
159Proximal amyotrophy (HP:0007126)1.62954807
160Epidermoid cyst (HP:0200040)1.62865402
161Aplasia/Hypoplasia of the thymus (HP:0010515)1.62610226
162Combined immunodeficiency (HP:0005387)1.61722330
163Syncope (HP:0001279)1.61691450
164Bladder diverticulum (HP:0000015)1.60986888
165Clitoromegaly (HP:0000057)1.59229645
166Spinal rigidity (HP:0003306)1.58488300
167Abnormal hand bone ossification (HP:0010660)1.57844010
168Lipoatrophy (HP:0100578)1.57143884
169Pancreatitis (HP:0001733)1.57052402
170Malignant hyperthermia (HP:0002047)1.56778977
171Bowel incontinence (HP:0002607)1.56316922
172Persistence of primary teeth (HP:0006335)1.54629752
173Wide anterior fontanel (HP:0000260)1.54526318
174Skin nodule (HP:0200036)1.53734216
175Abnormal eating behavior (HP:0100738)1.52440447
176Increased serum pyruvate (HP:0003542)1.51130137
177Annular pancreas (HP:0001734)1.50861061
178Vascular tortuosity (HP:0004948)1.50349372
179Abnormality of molar (HP:0011077)1.50252111
180Abnormality of molar morphology (HP:0011070)1.50252111
181Hyperglycemia (HP:0003074)1.46803453
182Blue sclerae (HP:0000592)1.45473369
183Pulmonary hypertension (HP:0002092)1.44554411
184Overgrowth (HP:0001548)1.44271965
185Striae distensae (HP:0001065)1.43367631
186Joint laxity (HP:0001388)1.42046252
187Broad palm (HP:0001169)1.41094165
188Juvenile onset (HP:0003621)1.40744450
189Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.40574943
190Abnormality of alanine metabolism (HP:0010916)1.40574943
191Hyperalaninemia (HP:0003348)1.40574943
192Aplasia/Hypoplasia of the clavicles (HP:0006710)1.40494672

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CG4.89161342
2OBSCN3.81218036
3PHKG13.04159076
4PHKG23.04159076
5PDK42.89152748
6PDK32.89152748
7NEK12.88805181
8TRIB32.86372750
9MAPK152.65257176
10MYLK2.51323874
11MAP2K32.38590471
12STK392.25033817
13PINK12.11741341
14PDK22.01525344
15TTN10.9049100
16BCKDK1.71835438
17LATS11.61282034
18DMPK1.56407874
19EPHA31.53912835
20PKN21.40656944
21PDGFRB1.37805769
22TESK11.35045970
23TAOK11.34527802
24MAP2K41.34012523
25MAPKAPK31.33149426
26FGFR41.28347604
27MAP3K71.23315196
28FGFR31.20604921
29CAMK1D1.16507795
30CAMK11.16115247
31OXSR11.14094698
32NME11.13135367
33MAPK121.11746868
34MAP3K31.00896754
35NLK1.00684450
36MAP2K20.98032294
37KSR20.95309806
38ZAP700.93152756
39PRKAA10.90775301
40FER0.88658681
41CAMKK20.88359297
42KDR0.87452178
43MAP2K60.87383113
44GRK70.85888899
45ADRBK10.81789545
46RIPK10.81314305
47AKT30.79904250
48GRK10.78829281
49ERN10.75122118
50MAP3K110.74134626
51MET0.73920853
52MTOR0.72397912
53CLK10.70883402
54CDC42BPA0.69702796
55MAPK110.68002808
56RPS6KA20.67752385
57MAPK70.66832026
58MAP3K90.66329733
59PRKD10.65669379
60CAMK2A0.65454571
61RPS6KC10.64540241
62RPS6KL10.64540241
63CDK60.63169794
64EPHB10.61473354
65PAK60.61203479
66PTK60.60489038
67PIK3CA0.60430156
68MAP3K20.56845818
69ERBB30.56325991
70LRRK20.55747094
71WNK40.54349181
72STK30.53596508
73MAPK30.53576260
74RPS6KA60.52505007
75CDK30.52263921
76CAMK1G0.52153333
77CDK90.50747898
78RPS6KB20.48642067
79MAP3K60.47676151
80JAK30.46495356
81ABL20.45686140
82IGF1R0.44854874
83MAP3K10.44053659
84MAPK10.43452340
85PTK20.43288708
86LIMK10.42100393
87PRKCH0.41700276
88CAMK2G0.41425201
89PDK10.41189551
90PDPK10.40203124
91LATS20.39792335
92INSR0.39118065
93SGK10.38654136
94STK38L0.37121081
95MAP2K10.36381842
96KIT0.35908646
97WNK10.34642881
98TGFBR20.34234812
99TAOK20.33007761
100PKN10.32762230
101ERBB20.32000278
102SGK4940.31171584
103SGK2230.31171584
104PRKD30.31003678
105SMG10.30428899
106JAK10.30427044
107BMX0.29703113
108PRKAA20.29211791
109PIM20.28901605
110GRK50.28668726
111ILK0.28077431
112TRPM70.27825284
113PAK30.27580933
114TIE10.27513695
115SGK20.26714410
116RET0.26527792
117SGK30.26259062
118STK110.26100055
119RPS6KA30.25794991
120SIK10.25761495
121DYRK1B0.25392036
122CDK40.25101886
123EPHA40.24499792
124AKT20.24456012
125NTRK10.24307269
126NTRK30.24042796
127ROCK20.23864454
128AKT10.23161300
129PDGFRA0.22418808
130PRKACA0.22372080
131CDK190.22044216
132MAPK40.21578219
133DDR20.21158949
134EEF2K0.21066871
135PRKACG0.20468837
136PRKG10.20392631
137MST1R0.19176547
138MUSK0.18842686
139MARK10.18683016
140CAMKK10.17754693
141PRKACB0.17730182
142ROCK10.17654063
143CDK50.16990725
144JAK20.15405211
145FGFR10.15200257
146EPHB20.14664064
147ALK0.14112601
148PAK20.13159204
149MINK10.12094151
150MAPKAPK20.11613601
151FGR0.11126266
152PTK2B0.10770284
153ICK0.10643426
154UHMK10.10599814
155DAPK20.10222263
156TYRO30.08539844
157FYN0.08342855
158GSK3A0.08294698

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049668.37999941
2Vitamin digestion and absorption_Homo sapiens_hsa049775.36796005
3Salivary secretion_Homo sapiens_hsa049704.55027070
4Protein digestion and absorption_Homo sapiens_hsa049744.30369342
5Phenylalanine metabolism_Homo sapiens_hsa003604.10656216
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.07709788
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.83576658
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.36013731
9* Glycerolipid metabolism_Homo sapiens_hsa005612.57830518
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.40407545
11Histidine metabolism_Homo sapiens_hsa003402.25179763
12Tyrosine metabolism_Homo sapiens_hsa003502.21528549
13beta-Alanine metabolism_Homo sapiens_hsa004102.21482959
14Fatty acid degradation_Homo sapiens_hsa000712.06310054
15Propanoate metabolism_Homo sapiens_hsa006402.00001075
16Carbon metabolism_Homo sapiens_hsa012001.96872409
17Mineral absorption_Homo sapiens_hsa049781.87362163
18Arginine biosynthesis_Homo sapiens_hsa002201.79821644
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69868958
20Cardiac muscle contraction_Homo sapiens_hsa042601.69012287
21Alzheimers disease_Homo sapiens_hsa050101.58930288
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55848355
23Nitrogen metabolism_Homo sapiens_hsa009101.54319892
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.50668746
25Parkinsons disease_Homo sapiens_hsa050121.44223550
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.43380914
27Glucagon signaling pathway_Homo sapiens_hsa049221.39105864
28Fatty acid metabolism_Homo sapiens_hsa012121.38979162
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38148921
30Biosynthesis of amino acids_Homo sapiens_hsa012301.37926960
31Pyruvate metabolism_Homo sapiens_hsa006201.36723060
32Chemical carcinogenesis_Homo sapiens_hsa052041.34189096
33Oxidative phosphorylation_Homo sapiens_hsa001901.33872608
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32722101
35Starch and sucrose metabolism_Homo sapiens_hsa005001.31892733
36Dilated cardiomyopathy_Homo sapiens_hsa054141.22739218
37Olfactory transduction_Homo sapiens_hsa047401.21103251
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.18202653
39Renin secretion_Homo sapiens_hsa049241.14541661
40Butanoate metabolism_Homo sapiens_hsa006501.06612785
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03341132
42Gastric acid secretion_Homo sapiens_hsa049711.01806411
43Phototransduction_Homo sapiens_hsa047440.98721295
44GnRH signaling pathway_Homo sapiens_hsa049120.98458042
45Oxytocin signaling pathway_Homo sapiens_hsa049210.96488397
46Insulin signaling pathway_Homo sapiens_hsa049100.95941234
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91742213
48Long-term potentiation_Homo sapiens_hsa047200.91739087
49Sulfur relay system_Homo sapiens_hsa041220.90092354
50Circadian entrainment_Homo sapiens_hsa047130.87212283
51ECM-receptor interaction_Homo sapiens_hsa045120.86675814
52PPAR signaling pathway_Homo sapiens_hsa033200.83548477
53Arginine and proline metabolism_Homo sapiens_hsa003300.83534421
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81643679
55Insulin resistance_Homo sapiens_hsa049310.80919869
56Calcium signaling pathway_Homo sapiens_hsa040200.80247966
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79884649
58Fatty acid elongation_Homo sapiens_hsa000620.79773321
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76443391
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.75392597
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74672567
62Tryptophan metabolism_Homo sapiens_hsa003800.73042964
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.72277954
64Glioma_Homo sapiens_hsa052140.67203872
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67197540
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65931602
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64303901
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.64176763
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62046354
70Amphetamine addiction_Homo sapiens_hsa050310.60921340
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.60754775
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.59149655
73VEGF signaling pathway_Homo sapiens_hsa043700.57210931
74Melanogenesis_Homo sapiens_hsa049160.57017934
75Huntingtons disease_Homo sapiens_hsa050160.55944585
76Hepatitis C_Homo sapiens_hsa051600.55670275
77Arachidonic acid metabolism_Homo sapiens_hsa005900.54992384
78AMPK signaling pathway_Homo sapiens_hsa041520.53260732
79Ovarian steroidogenesis_Homo sapiens_hsa049130.53025488
80Sulfur metabolism_Homo sapiens_hsa009200.51183288
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50950304
82Pertussis_Homo sapiens_hsa051330.49352229
83Estrogen signaling pathway_Homo sapiens_hsa049150.49236502
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.49136933
85TNF signaling pathway_Homo sapiens_hsa046680.47444107
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47342979
87Long-term depression_Homo sapiens_hsa047300.47332965
88Notch signaling pathway_Homo sapiens_hsa043300.46813971
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46245076
90Fructose and mannose metabolism_Homo sapiens_hsa000510.45752088
91Bile secretion_Homo sapiens_hsa049760.45639132
92Malaria_Homo sapiens_hsa051440.44547421
93Galactose metabolism_Homo sapiens_hsa000520.42925625
94Chronic myeloid leukemia_Homo sapiens_hsa052200.40717896
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.39909671
96Thyroid hormone synthesis_Homo sapiens_hsa049180.39653439
97Dopaminergic synapse_Homo sapiens_hsa047280.39564689
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.39265597
99Acute myeloid leukemia_Homo sapiens_hsa052210.38224235
100Tight junction_Homo sapiens_hsa045300.37625192
101Pancreatic secretion_Homo sapiens_hsa049720.37149751
102Amoebiasis_Homo sapiens_hsa051460.37080901
103Fatty acid biosynthesis_Homo sapiens_hsa000610.37039366
104Pentose phosphate pathway_Homo sapiens_hsa000300.36505419
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.36099184
106Serotonergic synapse_Homo sapiens_hsa047260.33835519
107cAMP signaling pathway_Homo sapiens_hsa040240.33135736
108Prolactin signaling pathway_Homo sapiens_hsa049170.30796407
109* Fat digestion and absorption_Homo sapiens_hsa049750.29619151
110Type II diabetes mellitus_Homo sapiens_hsa049300.29155657
111Other glycan degradation_Homo sapiens_hsa005110.28598859
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28566595
113Peroxisome_Homo sapiens_hsa041460.28165320
114Cocaine addiction_Homo sapiens_hsa050300.27771946
115Retinol metabolism_Homo sapiens_hsa008300.27600253
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.26703274
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26225594
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25828701
119Lysine degradation_Homo sapiens_hsa003100.25358804
120Rap1 signaling pathway_Homo sapiens_hsa040150.25229086
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.25048491
122Adherens junction_Homo sapiens_hsa045200.24719748
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24113626
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.23955271
125Focal adhesion_Homo sapiens_hsa045100.23898972
126Complement and coagulation cascades_Homo sapiens_hsa046100.23834797
127Inositol phosphate metabolism_Homo sapiens_hsa005620.23654797
128Prion diseases_Homo sapiens_hsa050200.23318158
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23122250
130Platelet activation_Homo sapiens_hsa046110.22995240
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.22736503
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22705204
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.22088728
134Gap junction_Homo sapiens_hsa045400.22005967
135Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.21291729
136Small cell lung cancer_Homo sapiens_hsa052220.21156791
137TGF-beta signaling pathway_Homo sapiens_hsa043500.21148233
138Insulin secretion_Homo sapiens_hsa049110.20754505
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20740785
140Pathways in cancer_Homo sapiens_hsa052000.20679470
141HIF-1 signaling pathway_Homo sapiens_hsa040660.19220531
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18871993
143GABAergic synapse_Homo sapiens_hsa047270.18621095
144Hedgehog signaling pathway_Homo sapiens_hsa043400.18183034
145Proteoglycans in cancer_Homo sapiens_hsa052050.18127351
146Cholinergic synapse_Homo sapiens_hsa047250.16577531
147Renal cell carcinoma_Homo sapiens_hsa052110.14639426
148Osteoclast differentiation_Homo sapiens_hsa043800.14003950
149Thyroid cancer_Homo sapiens_hsa052160.10992464

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