LIPG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibrinolysis (GO:0051918)4.96649725
2peptidyl-glutamic acid carboxylation (GO:0017187)4.96311888
3protein carboxylation (GO:0018214)4.96311888
4L-phenylalanine catabolic process (GO:0006559)4.67297536
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.67297536
6alpha-linolenic acid metabolic process (GO:0036109)4.63864132
7low-density lipoprotein particle clearance (GO:0034383)4.51552017
8kynurenine metabolic process (GO:0070189)4.47402752
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.45174595
10L-phenylalanine metabolic process (GO:0006558)4.45174595
11aromatic amino acid family catabolic process (GO:0009074)4.38445735
12disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.37769568
13killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.37769568
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.36919779
15* high-density lipoprotein particle remodeling (GO:0034375)4.31366460
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.30730243
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.30730243
18regulation of fibrinolysis (GO:0051917)4.27711985
19defense response to fungus (GO:0050832)4.25429112
20plasma lipoprotein particle clearance (GO:0034381)4.19427056
21urea metabolic process (GO:0019627)4.18857507
22urea cycle (GO:0000050)4.18857507
23regulation of protein activation cascade (GO:2000257)4.18437840
24complement activation, alternative pathway (GO:0006957)4.14654020
25sulfur amino acid catabolic process (GO:0000098)4.10842627
26indole-containing compound catabolic process (GO:0042436)4.07672258
27indolalkylamine catabolic process (GO:0046218)4.07672258
28tryptophan catabolic process (GO:0006569)4.07672258
29regulation of complement activation (GO:0030449)4.02846435
30limb bud formation (GO:0060174)3.93366860
31ethanol oxidation (GO:0006069)3.91688106
32leukocyte migration involved in inflammatory response (GO:0002523)3.90706889
33negative regulation of sterol transport (GO:0032372)3.86573372
34negative regulation of cholesterol transport (GO:0032375)3.86573372
35bile acid biosynthetic process (GO:0006699)3.83831221
36tryptophan metabolic process (GO:0006568)3.82519428
37homocysteine metabolic process (GO:0050667)3.79491818
38exogenous drug catabolic process (GO:0042738)3.79211954
39regulation of triglyceride catabolic process (GO:0010896)3.78204623
40* reverse cholesterol transport (GO:0043691)3.76347766
41killing of cells of other organism (GO:0031640)3.73190055
42disruption of cells of other organism (GO:0044364)3.73190055
43negative regulation of keratinocyte proliferation (GO:0010839)3.69521067
44nitrogen cycle metabolic process (GO:0071941)3.68885770
45neuronal stem cell maintenance (GO:0097150)3.66401413
46glyoxylate metabolic process (GO:0046487)3.65126129
47cysteine metabolic process (GO:0006534)3.62587506
48fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.61180678
49sequestering of metal ion (GO:0051238)3.61126560
50presynaptic membrane assembly (GO:0097105)3.60002392
51phospholipid efflux (GO:0033700)3.59324830
52regulation of cholesterol homeostasis (GO:2000188)3.58897813
53detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.52586589
54response to fungus (GO:0009620)3.51291977
55cholesterol efflux (GO:0033344)3.51199645
56epoxygenase P450 pathway (GO:0019373)3.50545335
57hemidesmosome assembly (GO:0031581)3.48030638
58antigen processing and presentation of endogenous antigen (GO:0019883)3.46710184
59pentose-phosphate shunt (GO:0006098)3.46289199
60* plasma lipoprotein particle remodeling (GO:0034369)3.44785415
61* protein-lipid complex remodeling (GO:0034368)3.44785415
62* macromolecular complex remodeling (GO:0034367)3.44785415
63thyroid hormone generation (GO:0006590)3.44063748
64chronic inflammatory response (GO:0002544)3.43587185
65progesterone metabolic process (GO:0042448)3.43490983
66NADPH regeneration (GO:0006740)3.43055623
67thyroid hormone metabolic process (GO:0042403)3.42990789
684-hydroxyproline metabolic process (GO:0019471)3.41047857
69plasma lipoprotein particle assembly (GO:0034377)3.40822869
70presynaptic membrane organization (GO:0097090)3.40614867
71primary alcohol catabolic process (GO:0034310)3.40461649
72benzene-containing compound metabolic process (GO:0042537)3.40041676
73negative regulation of astrocyte differentiation (GO:0048712)3.38870402
74bile acid metabolic process (GO:0008206)3.37458916
75ethanol metabolic process (GO:0006067)3.34252840
76protein-lipid complex assembly (GO:0065005)3.32259641
77amino-acid betaine metabolic process (GO:0006577)3.31956210
78imidazole-containing compound metabolic process (GO:0052803)3.22719976
79negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.22462124
80behavioral response to nicotine (GO:0035095)3.21470758
81positive regulation of lipid catabolic process (GO:0050996)3.19599277
82drug catabolic process (GO:0042737)3.18888960
83pyrimidine nucleobase catabolic process (GO:0006208)3.18445553
84fibrinolysis (GO:0042730)3.18433187
85regulation of hippo signaling (GO:0035330)3.16163324
86regulation of cholesterol esterification (GO:0010872)3.15029532
87lysine catabolic process (GO:0006554)3.12685796
88lysine metabolic process (GO:0006553)3.12685796
89cell proliferation in forebrain (GO:0021846)3.11321539
90acylglycerol homeostasis (GO:0055090)3.10528051
91triglyceride homeostasis (GO:0070328)3.10528051
92postsynaptic membrane organization (GO:0001941)3.09656377
93cellular glucuronidation (GO:0052695)3.09556127
94* phospholipid homeostasis (GO:0055091)3.09113950
95regulation of cholesterol storage (GO:0010885)3.08812646
96* cholesterol homeostasis (GO:0042632)3.08551499
97NADP metabolic process (GO:0006739)3.07357438
98lymphangiogenesis (GO:0001946)3.07241181
99* sterol homeostasis (GO:0055092)3.06364379
100lateral sprouting from an epithelium (GO:0060601)3.05407374
101artery development (GO:0060840)3.03515782
102positive regulation of blood coagulation (GO:0030194)3.01677950
103positive regulation of hemostasis (GO:1900048)3.01677950
104oxidative demethylation (GO:0070989)3.01029172
105aromatic amino acid family metabolic process (GO:0009072)3.00603376
106cellular response to cholesterol (GO:0071397)3.00395419
107negative regulation of oligodendrocyte differentiation (GO:0048715)2.99874902
108negative regulation of axon extension involved in axon guidance (GO:0048843)2.99619489
109positive regulation of triglyceride metabolic process (GO:0090208)2.99034927
110cellular response to sterol (GO:0036315)2.98994784
111serine family amino acid biosynthetic process (GO:0009070)2.98507117
112nephron tubule formation (GO:0072079)2.98365609
113serine family amino acid catabolic process (GO:0009071)2.97605143
114positive regulation of lipoprotein lipase activity (GO:0051006)2.96051171
115positive regulation of triglyceride lipase activity (GO:0061365)2.96051171
116regulation of fatty acid beta-oxidation (GO:0031998)2.95667466
117bile acid and bile salt transport (GO:0015721)2.95412694
118* plasma lipoprotein particle organization (GO:0071827)2.93146082
119very-low-density lipoprotein particle assembly (GO:0034379)2.92480266
120antigen processing and presentation via MHC class Ib (GO:0002475)2.92437186
121leukocyte aggregation (GO:0070486)2.92174413
122* protein-lipid complex subunit organization (GO:0071825)2.91186597
123negative regulation of protein activation cascade (GO:2000258)2.89808955
124flavonoid metabolic process (GO:0009812)2.89572596
125protein activation cascade (GO:0072376)2.88353217
126positive regulation of coagulation (GO:0050820)2.88105538
127cellular ketone body metabolic process (GO:0046950)2.87090960
128omega-hydroxylase P450 pathway (GO:0097267)2.86245033
129negative regulation of axon guidance (GO:1902668)2.78737169
130epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.77188835
131otic vesicle formation (GO:0030916)2.75347113
132nucleobase catabolic process (GO:0046113)2.73075712
133regulation of keratinocyte proliferation (GO:0010837)2.71746495
134neural crest cell development (GO:0014032)2.70698454
135auditory receptor cell differentiation (GO:0042491)2.69972735
136phasic smooth muscle contraction (GO:0014821)2.69774116
137heart valve formation (GO:0003188)2.69630806
138retinal ganglion cell axon guidance (GO:0031290)2.65561514
139nonmotile primary cilium assembly (GO:0035058)2.62026683
140arginine catabolic process (GO:0006527)2.59991239
141L-fucose catabolic process (GO:0042355)2.59077317
142fucose catabolic process (GO:0019317)2.59077317
143L-fucose metabolic process (GO:0042354)2.59077317
144detection of mechanical stimulus involved in sensory perception (GO:0050974)2.58472457
145kidney morphogenesis (GO:0060993)2.58354342
146neuron fate determination (GO:0048664)2.57808690
147negative chemotaxis (GO:0050919)2.55535338
148Notch signaling involved in heart development (GO:0061314)2.55497445
149ketone body metabolic process (GO:1902224)2.54096817
150limb development (GO:0060173)2.53984348
151appendage development (GO:0048736)2.53984348
152axon ensheathment in central nervous system (GO:0032291)2.52648618
153central nervous system myelination (GO:0022010)2.52648618
154cerebral cortex radially oriented cell migration (GO:0021799)2.50594989
155regulation of mesenchymal cell apoptotic process (GO:2001053)2.50581471
156negative regulation of lipase activity (GO:0060192)2.50427213
157mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.48511268
158calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.47224156
159indolalkylamine metabolic process (GO:0006586)2.46713286
160negative regulation of glial cell differentiation (GO:0045686)2.46290471
161tongue development (GO:0043586)2.44230677
162regulation of axon extension involved in axon guidance (GO:0048841)2.44161080
163sulfation (GO:0051923)2.42963795
164signal peptide processing (GO:0006465)2.42377512
165reflex (GO:0060004)2.40828913
166response to pheromone (GO:0019236)2.38977887
167regulation of astrocyte differentiation (GO:0048710)2.38933950
168regulation of axon guidance (GO:1902667)2.37173510
169gamma-aminobutyric acid transport (GO:0015812)2.35905145
170nephron epithelium morphogenesis (GO:0072088)2.33288226
171nephron tubule morphogenesis (GO:0072078)2.33288226
172regulation of mesoderm development (GO:2000380)2.32582968
173arginine metabolic process (GO:0006525)2.30972530
174pattern specification involved in kidney development (GO:0061004)2.30917413
175inner ear receptor stereocilium organization (GO:0060122)2.30432080
176negative regulation of chondrocyte differentiation (GO:0032331)2.30110001
177dorsal/ventral axis specification (GO:0009950)2.25376520
178cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.25130762
179water-soluble vitamin biosynthetic process (GO:0042364)2.23828280
180stem cell development (GO:0048864)2.23639331
181platelet dense granule organization (GO:0060155)2.22379871
182renal tubule morphogenesis (GO:0061333)2.20574642
183cochlea development (GO:0090102)2.20435109
184mechanoreceptor differentiation (GO:0042490)2.20298006
185retina vasculature morphogenesis in camera-type eye (GO:0061299)2.20033354
186inner ear receptor cell differentiation (GO:0060113)2.19457563

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.77916941
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.52273984
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.00839791
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.56322452
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.48557104
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.72674128
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.24908283
8EZH2_22144423_ChIP-Seq_EOC_Human3.17401595
9GBX2_23144817_ChIP-Seq_PC3_Human3.17316028
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.14455768
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.01666923
12CLOCK_20551151_ChIP-Seq_293T_Human2.74966576
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.74181122
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67219853
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.63100482
16ZNF274_21170338_ChIP-Seq_K562_Hela2.60531958
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.59962253
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.51401036
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.43658826
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.40489945
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40130292
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.37011639
23ESR1_15608294_ChIP-ChIP_MCF-7_Human2.34469010
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33478129
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.25005110
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13423204
27TAF15_26573619_Chip-Seq_HEK293_Human2.12746246
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03483742
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.01160022
30* P300_19829295_ChIP-Seq_ESCs_Human1.99492991
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.98503294
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97467749
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97011195
34* PIAS1_25552417_ChIP-Seq_VCAP_Human1.95601779
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.93838210
36VDR_22108803_ChIP-Seq_LS180_Human1.92315021
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90772437
38* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.78276906
39IGF1R_20145208_ChIP-Seq_DFB_Human1.77962209
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.75359189
41SMAD4_21799915_ChIP-Seq_A2780_Human1.74795243
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.73010126
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70683484
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.69826206
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68206420
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.67666650
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.65760151
48TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.65228413
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65159400
50ER_23166858_ChIP-Seq_MCF-7_Human1.64869358
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64838500
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62761285
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60021684
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59403594
55FUS_26573619_Chip-Seq_HEK293_Human1.58063733
56AR_21572438_ChIP-Seq_LNCaP_Human1.56297280
57BCAT_22108803_ChIP-Seq_LS180_Human1.55257845
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.54684539
59* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53737699
60AR_25329375_ChIP-Seq_VCAP_Human1.53723392
61TP53_16413492_ChIP-PET_HCT116_Human1.52928519
62SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52189686
63* STAT3_23295773_ChIP-Seq_U87_Human1.51309708
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.50986563
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.50981861
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.50908064
67VDR_21846776_ChIP-Seq_THP-1_Human1.49721408
68* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49482778
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.48126295
70IRF8_27001747_Chip-Seq_BMDM_Mouse1.47398015
71EWS_26573619_Chip-Seq_HEK293_Human1.46929227
72CJUN_26792858_Chip-Seq_BT549_Human1.44996821
73* TP53_18474530_ChIP-ChIP_U2OS_Human1.44710451
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.44626804
75RACK7_27058665_Chip-Seq_MCF-7_Human1.43976115
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.43741763
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43483930
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43079145
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.42732703
80ESR1_21235772_ChIP-Seq_MCF-7_Human1.40435315
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40224869
82TRIM28_21343339_ChIP-Seq_HEK293_Human1.39686658
83LXR_22292898_ChIP-Seq_THP-1_Human1.39430558
84* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.38076740
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37929522
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.37517950
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32731031
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31847314
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31699540
90CBP_20019798_ChIP-Seq_JUKART_Human1.31699540
91GATA1_22025678_ChIP-Seq_K562_Human1.31512108
92TCF4_23295773_ChIP-Seq_U87_Human1.30105200
93RUNX2_22187159_ChIP-Seq_PCA_Human1.29378200
94TCF4_22108803_ChIP-Seq_LS180_Human1.29021186
95* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28752007
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28249455
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28120336
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27638742
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27638742
100GATA4_25053715_ChIP-Seq_YYC3_Human1.27637434
101HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26729664
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.26616450
103HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25391117
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25068771
105* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.24889690
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24422044
107FOXA2_19822575_ChIP-Seq_HepG2_Human1.24269820
108ZNF263_19887448_ChIP-Seq_K562_Human1.23865997
109IRF8_22096565_ChIP-ChIP_GC-B_Human1.23675743
110EP300_21415370_ChIP-Seq_HL-1_Mouse1.22960149
111AHR_22903824_ChIP-Seq_MCF-7_Human1.22097167
112* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.22049237
113RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21443922
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21185893
115MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20660210
116ARNT_22903824_ChIP-Seq_MCF-7_Human1.19354760
117CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19133413
118GATA6_25053715_ChIP-Seq_YYC3_Human1.18772844
119SMAD3_21741376_ChIP-Seq_HESCs_Human1.18700319
120PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18019937
121CDX2_22108803_ChIP-Seq_LS180_Human1.17391762
122SMAD4_21741376_ChIP-Seq_EPCs_Human1.16935410
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14910218
124TCF7_22412390_ChIP-Seq_EML_Mouse1.14827980
125EZH2_27294783_Chip-Seq_NPCs_Mouse1.14345786
126STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13919521
127RNF2_27304074_Chip-Seq_NSC_Mouse1.13796515
128* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13753751
129JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13622306
130VDR_24763502_ChIP-Seq_THP-1_Human1.13417622
131EZH2_27304074_Chip-Seq_ESCs_Mouse1.13215041
132MYC_22102868_ChIP-Seq_BL_Human1.12971524
133SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12545985
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12394776
135* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12142859
136SOX2_21211035_ChIP-Seq_LN229_Gbm1.12122168
137SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11415420
138CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11265188
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10972372
140MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10898276
141NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10622635
142NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10622635
143RXR_22108803_ChIP-Seq_LS180_Human1.10512483
144LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10354157
145* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10328553
146SMAD4_21741376_ChIP-Seq_HESCs_Human1.09977364
147TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09050861
148ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08850242
149NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08718190
150* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08603811
151TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08277413
152TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08083370
153* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07722956
154* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06273808
155KDM2B_26808549_Chip-Seq_REH_Human1.05918833
156KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05743676
157KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05691923
158* RNF2_27304074_Chip-Seq_ESCs_Mouse1.05675705
159* FOXO3_23340844_ChIP-Seq_DLD1_Human1.04829842
160P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04063019
161FLI1_21867929_ChIP-Seq_TH2_Mouse1.03930381
162AR_21909140_ChIP-Seq_LNCAP_Human1.02084015
163MAF_26560356_Chip-Seq_TH1_Human1.00631333
164* ATF3_27146783_Chip-Seq_COLON_Human1.00082785
165RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98974457
166CDX2_20551321_ChIP-Seq_CACO-2_Human0.98320068
167EGR1_19032775_ChIP-ChIP_M12_Human0.97772367
168GATA1_19941826_ChIP-Seq_K562_Human0.96494448
169SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96332390
170SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96332390
171* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94930592
172HNF4A_19822575_ChIP-Seq_HepG2_Human0.93530700
173BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92968976
174ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91491283
175GATA2_19941826_ChIP-Seq_K562_Human0.90883039
176* SOX2_20726797_ChIP-Seq_SW620_Human0.88764343
177GATA2_21666600_ChIP-Seq_HMVEC_Human0.88557706
178KDM2B_26808549_Chip-Seq_DND41_Human0.88246084
179UTX_26944678_Chip-Seq_JUKART_Human0.88008274
180P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87415751
181RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87004421
182STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86655714
183TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86378922
184NCOR1_26117541_ChIP-Seq_K562_Human0.85022754
185KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83133298
186CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82298323
187E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.81917073
188PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81305243
189VDR_24787735_ChIP-Seq_THP-1_Human0.80580441
190RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79646303
191RUNX1_22412390_ChIP-Seq_EML_Mouse0.79320512
192* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78626098
193PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78272111
194RUNX1_27514584_Chip-Seq_MCF-7_Human0.77974654
195STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.77374413

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.60788101
2MP0005360_urolithiasis5.30459464
3MP0005085_abnormal_gallbladder_physiolo3.96875296
4MP0005365_abnormal_bile_salt3.82034355
5MP0008875_abnormal_xenobiotic_pharmacok3.80446346
6MP0003136_yellow_coat_color3.31091124
7MP0009840_abnormal_foam_cell3.29690750
8MP0003303_peritoneal_inflammation3.17423667
9MP0000566_synostosis2.96894934
10MP0004885_abnormal_endolymph2.93414990
11MP0003705_abnormal_hypodermis_morpholog2.91329077
12* MP0010329_abnormal_lipoprotein_level2.66064385
13MP0003300_gastrointestinal_ulcer2.44174011
14MP0000579_abnormal_nail_morphology2.29202746
15MP0000537_abnormal_urethra_morphology2.27838668
16MP0003806_abnormal_nucleotide_metabolis2.26778520
17MP0003252_abnormal_bile_duct2.24788653
18MP0005083_abnormal_biliary_tract2.23786332
19MP0003724_increased_susceptibility_to2.23144621
20MP0002234_abnormal_pharynx_morphology2.14083185
21MP0006292_abnormal_olfactory_placode2.13887496
22MP0003191_abnormal_cellular_cholesterol2.11933865
23MP0000778_abnormal_nervous_system2.05832364
24MP0002876_abnormal_thyroid_physiology1.99081869
25MP0010368_abnormal_lymphatic_system1.85778645
26MP0003436_decreased_susceptibility_to1.80689276
27MP0001485_abnormal_pinna_reflex1.80093800
28MP0006054_spinal_hemorrhage1.80071612
29MP0000609_abnormal_liver_physiology1.78234274
30MP0002282_abnormal_trachea_morphology1.77238506
31MP0003566_abnormal_cell_adhesion1.74137336
32MP0001666_abnormal_nutrient_absorption1.72891029
33MP0000569_abnormal_digit_pigmentation1.69849850
34MP0003890_abnormal_embryonic-extraembry1.67702737
35MP0002928_abnormal_bile_duct1.67166429
36MP0004019_abnormal_vitamin_homeostasis1.62636881
37MP0005464_abnormal_platelet_physiology1.60668982
38MP0002638_abnormal_pupillary_reflex1.58936164
39MP0000762_abnormal_tongue_morphology1.57502721
40MP0004264_abnormal_extraembryonic_tissu1.57097953
41MP0005319_abnormal_enzyme/_coenzyme1.55935884
42MP0004272_abnormal_basement_membrane1.54776425
43MP0005332_abnormal_amino_acid1.54461202
44MP0000049_abnormal_middle_ear1.53008906
45MP0005187_abnormal_penis_morphology1.51227011
46* MP0002118_abnormal_lipid_homeostasis1.47776254
47MP0000026_abnormal_inner_ear1.45704148
48MP0005551_abnormal_eye_electrophysiolog1.44622990
49MP0004947_skin_inflammation1.42872813
50MP0005023_abnormal_wound_healing1.42786725
51MP0003195_calcinosis1.40934228
52MP0004133_heterotaxia1.40569507
53MP0003755_abnormal_palate_morphology1.39861822
54MP0002254_reproductive_system_inflammat1.39255561
55MP0002138_abnormal_hepatobiliary_system1.34967422
56MP0003183_abnormal_peptide_metabolism1.34836090
57MP0000604_amyloidosis1.32783110
58MP0005058_abnormal_lysosome_morphology1.31978372
59MP0003186_abnormal_redox_activity1.28787812
60MP0002419_abnormal_innate_immunity1.28077264
61MP0010352_gastrointestinal_tract_polyps1.27947310
62MP0002938_white_spotting1.27920690
63MP0002653_abnormal_ependyma_morphology1.27738713
64MP0003878_abnormal_ear_physiology1.27633799
65MP0005377_hearing/vestibular/ear_phenot1.27633799
66MP0000343_altered_response_to1.26069247
67MP0003937_abnormal_limbs/digits/tail_de1.25728749
68MP0009764_decreased_sensitivity_to1.24106710
69MP0001533_abnormal_skeleton_physiology1.23746022
70MP0009278_abnormal_bone_marrow1.23737648
71MP0003119_abnormal_digestive_system1.21816403
72MP0000631_abnormal_neuroendocrine_gland1.21214412
73MP0001293_anophthalmia1.21068335
74MP0000427_abnormal_hair_cycle1.20165550
75MP0009785_altered_susceptibility_to1.18976342
76MP0005164_abnormal_response_to1.18332608
77MP0005084_abnormal_gallbladder_morpholo1.17579840
78MP0000598_abnormal_liver_morphology1.15442619
79MP0000538_abnormal_urinary_bladder1.14866949
80MP0000516_abnormal_urinary_system1.14155019
81MP0005367_renal/urinary_system_phenotyp1.14155019
82MP0006072_abnormal_retinal_apoptosis1.13285814
83MP0000467_abnormal_esophagus_morphology1.11100790
84MP0008469_abnormal_protein_level1.10301197
85MP0005076_abnormal_cell_differentiation1.10214052
86MP0009763_increased_sensitivity_to1.09492845
87MP0003221_abnormal_cardiomyocyte_apopto1.08934840
88MP0001851_eye_inflammation1.08331434
89MP0005195_abnormal_posterior_eye1.07084866
90MP0001501_abnormal_sleep_pattern1.06789136
91MP0002697_abnormal_eye_size1.06556190
92MP0000613_abnormal_salivary_gland1.06509881
93MP0003453_abnormal_keratinocyte_physiol1.05123973
94MP0002233_abnormal_nose_morphology1.03964594
95MP0010234_abnormal_vibrissa_follicle1.03734044
96MP0009053_abnormal_anal_canal1.03627368
97MP0004270_analgesia1.02669659
98MP0005451_abnormal_body_composition1.02658290
99MP0001845_abnormal_inflammatory_respons1.00651317
100MP0001984_abnormal_olfaction1.00117471
101MP0005584_abnormal_enzyme/coenzyme_acti0.99706601
102MP0009643_abnormal_urine_homeostasis0.99293791
103MP0005253_abnormal_eye_physiology0.99000245
104MP0000465_gastrointestinal_hemorrhage0.98743439
105MP0004782_abnormal_surfactant_physiolog0.98597785
106MP0004883_abnormal_blood_vessel0.98560746
107MP0002796_impaired_skin_barrier0.98277332
108MP0002098_abnormal_vibrissa_morphology0.98123626
109MP0004043_abnormal_pH_regulation0.97918359
110MP0004142_abnormal_muscle_tone0.97693933
111MP0003935_abnormal_craniofacial_develop0.97182933
112MP0009384_cardiac_valve_regurgitation0.96795847
113MP0000647_abnormal_sebaceous_gland0.96169905
114MP0003329_amyloid_beta_deposits0.95927089
115MP0002102_abnormal_ear_morphology0.95403573
116MP0008872_abnormal_physiological_respon0.94224799
117MP0001286_abnormal_eye_development0.94213510
118MP0002736_abnormal_nociception_after0.93350680
119MP0005025_abnormal_response_to0.91453489
120MP0005391_vision/eye_phenotype0.91152636
121MP0003011_delayed_dark_adaptation0.89872891
122MP0005171_absent_coat_pigmentation0.87871092
123MP0008789_abnormal_olfactory_epithelium0.87748745
124MP0001764_abnormal_homeostasis0.87521278
125MP0005595_abnormal_vascular_smooth0.87174886
126MP0003075_altered_response_to0.87151544
127MP0001963_abnormal_hearing_physiology0.86733992
128MP0003880_abnormal_central_pattern0.86015202
129MP0003283_abnormal_digestive_organ0.85593665
130MP0005670_abnormal_white_adipose0.83931648
131MP0001968_abnormal_touch/_nociception0.81749708
132MP0003718_maternal_effect0.81261634
133MP0005646_abnormal_pituitary_gland0.80537122
134MP0005167_abnormal_blood-brain_barrier0.80380895
135* MP0000249_abnormal_blood_vessel0.80372751
136MP0001486_abnormal_startle_reflex0.80355240
137MP0003315_abnormal_perineum_morphology0.80184012
138MP0000428_abnormal_craniofacial_morphol0.79852312
139MP0010155_abnormal_intestine_physiology0.79279223
140MP0003868_abnormal_feces_composition0.79200818
141MP0002092_abnormal_eye_morphology0.77705834
142MP0002572_abnormal_emotion/affect_behav0.77618338
143MP0008438_abnormal_cutaneous_collagen0.77598385
144MP0001879_abnormal_lymphatic_vessel0.77567328
145MP0002557_abnormal_social/conspecific_i0.77472476
146MP0006276_abnormal_autonomic_nervous0.77405876
147MP0001915_intracranial_hemorrhage0.73351523
148MP0003122_maternal_imprinting0.73000231
149MP0002184_abnormal_innervation0.72735137
150MP0008004_abnormal_stomach_pH0.72651139
151MP0000955_abnormal_spinal_cord0.72205234
152MP0002752_abnormal_somatic_nervous0.72003903
153MP0002060_abnormal_skin_morphology0.71401514
154MP0002751_abnormal_autonomic_nervous0.71079195
155MP0004742_abnormal_vestibular_system0.70982374
156MP0009250_abnormal_appendicular_skeleto0.70822638
157MP0000685_abnormal_immune_system0.70344741
158MP0004858_abnormal_nervous_system0.70324690
159MP0010030_abnormal_orbit_morphology0.70218739
160MP0001881_abnormal_mammary_gland0.69087837
161MP0001853_heart_inflammation0.68680601
162MP0003172_abnormal_lysosome_physiology0.68027219
163MP0009765_abnormal_xenobiotic_induced0.67028931
164MP0001216_abnormal_epidermal_layer0.66996486
165MP0002405_respiratory_system_inflammati0.66419797
166MP0009931_abnormal_skin_appearance0.66109905
167* MP0009642_abnormal_blood_homeostasis0.65807749
168MP0010678_abnormal_skin_adnexa0.65758836
169MP0006082_CNS_inflammation0.65598577
170MP0002136_abnormal_kidney_physiology0.64850903
171MP0003091_abnormal_cell_migration0.64651178
172MP0001243_abnormal_dermal_layer0.62656103
173MP0000767_abnormal_smooth_muscle0.61441520
174MP0000383_abnormal_hair_follicle0.61129351
175MP0005636_abnormal_mineral_homeostasis0.61002098
176MP0004185_abnormal_adipocyte_glucose0.60581788
177MP0001756_abnormal_urination0.60091750
178MP0004510_myositis0.58771178
179MP0000013_abnormal_adipose_tissue0.58448340
180MP0004130_abnormal_muscle_cell0.57779969

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.08895406
2Eczematoid dermatitis (HP:0000976)5.58479900
3Xanthomatosis (HP:0000991)5.03893351
4Recurrent gram-negative bacterial infections (HP:0005420)5.01562556
5Intrahepatic cholestasis (HP:0001406)4.62587225
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.56587072
7Joint hemorrhage (HP:0005261)4.49821614
8Prolonged partial thromboplastin time (HP:0003645)4.41455676
9Hypobetalipoproteinemia (HP:0003563)4.30577547
10Abnormality of aromatic amino acid family metabolism (HP:0004338)4.30113481
11True hermaphroditism (HP:0010459)3.82618468
12Hyperlipoproteinemia (HP:0010980)3.77776461
13Complement deficiency (HP:0004431)3.75648072
14Abnormality of the common coagulation pathway (HP:0010990)3.75067166
15Epidermoid cyst (HP:0200040)3.57652169
16Recurrent bacterial skin infections (HP:0005406)3.47754451
17Hypolipoproteinemia (HP:0010981)3.39719072
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.29173121
19Pancreatic cysts (HP:0001737)3.28093667
20Menorrhagia (HP:0000132)3.27020756
21Myocardial infarction (HP:0001658)3.22071856
22Hyperventilation (HP:0002883)3.17002243
23Hypoalphalipoproteinemia (HP:0003233)3.15937085
24Pancreatic fibrosis (HP:0100732)3.15366077
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.14872398
26Vascular calcification (HP:0004934)3.06682638
27Abnormality of complement system (HP:0005339)3.05266871
28Chorioretinal atrophy (HP:0000533)3.04968958
29Esophageal varix (HP:0002040)2.97876142
30Increased mean platelet volume (HP:0011877)2.92054863
31Abnormal platelet volume (HP:0011876)2.87183813
32Abnormality of the intrinsic pathway (HP:0010989)2.84548681
33Thyroid-stimulating hormone excess (HP:0002925)2.83402134
34Cardiovascular calcification (HP:0011915)2.83072413
35Abnormality of midbrain morphology (HP:0002418)2.82006423
36Molar tooth sign on MRI (HP:0002419)2.82006423
37Abnormality of sulfur amino acid metabolism (HP:0004339)2.81487719
38Recurrent abscess formation (HP:0002722)2.81076541
39Neonatal short-limb short stature (HP:0008921)2.79700397
40Interstitial pulmonary disease (HP:0006530)2.75949133
41Gingival bleeding (HP:0000225)2.69496104
42Systemic lupus erythematosus (HP:0002725)2.67690201
43Hyperammonemia (HP:0001987)2.66450397
44Bronchomalacia (HP:0002780)2.59041836
45Nephronophthisis (HP:0000090)2.58995354
46Hypercholesterolemia (HP:0003124)2.57923952
47Hemiparesis (HP:0001269)2.57711961
48Gastrointestinal atresia (HP:0002589)2.57111810
49Nonimmune hydrops fetalis (HP:0001790)2.56716815
50Esophageal atresia (HP:0002032)2.56616751
51Osteolytic defects of the hand bones (HP:0009699)2.56384414
52Osteolytic defects of the phalanges of the hand (HP:0009771)2.56384414
53Abnormality of pyrimidine metabolism (HP:0004353)2.56191157
54Right ventricular cardiomyopathy (HP:0011663)2.55668769
55Abnormality of the renal medulla (HP:0100957)2.55360056
56Chronic hepatic failure (HP:0100626)2.55296061
57Keratoconus (HP:0000563)2.54378211
58Increased corneal curvature (HP:0100692)2.54378211
59Split foot (HP:0001839)2.47240677
60Milia (HP:0001056)2.42287973
61Peritonitis (HP:0002586)2.40779702
62Hypoglycemic coma (HP:0001325)2.40007572
63Spastic diplegia (HP:0001264)2.39509022
64Abnormality of the nasal septum (HP:0000419)2.38718469
65Type II lissencephaly (HP:0007260)2.38617068
66Fat malabsorption (HP:0002630)2.37074970
67Aplasia/Hypoplasia of the tibia (HP:0005772)2.37002729
68Sclerocornea (HP:0000647)2.35101611
69Fragile nails (HP:0001808)2.34080889
70Abnormality of nucleobase metabolism (HP:0010932)2.33337233
71Ketosis (HP:0001946)2.33192622
72Abnormality of macrophages (HP:0004311)2.31598924
73Cutaneous finger syndactyly (HP:0010554)2.31548277
74Fair hair (HP:0002286)2.29232385
75Abnormality of the renal cortex (HP:0011035)2.29181969
76Aplasia/Hypoplasia of the fibula (HP:0006492)2.23046872
77Pulmonary embolism (HP:0002204)2.22572681
78Abnormality of purine metabolism (HP:0004352)2.21910271
79Hemorrhage of the eye (HP:0011885)2.21902435
80Abnormality of methionine metabolism (HP:0010901)2.20278256
81Progressive cerebellar ataxia (HP:0002073)2.20244316
82Cystic liver disease (HP:0006706)2.19570055
83Abnormality of aspartate family amino acid metabolism (HP:0010899)2.19324781
84Preaxial foot polydactyly (HP:0001841)2.17351047
85Hypoplastic labia majora (HP:0000059)2.17078823
86Congenital sensorineural hearing impairment (HP:0008527)2.15646162
87Polycythemia (HP:0001901)2.14513833
88Recurrent skin infections (HP:0001581)2.14498050
89Urticaria (HP:0001025)2.13994610
90Amyloidosis (HP:0011034)2.13801846
91Abnormality of proline metabolism (HP:0010907)2.12987601
92Hydroxyprolinuria (HP:0003080)2.12987601
93Congenital stationary night blindness (HP:0007642)2.12302867
94Hypoplastic pelvis (HP:0008839)2.12241999
95Thrombophlebitis (HP:0004418)2.12056121
96Optic nerve hypoplasia (HP:0000609)2.11749154
97Purpura (HP:0000979)2.11623150
98Nephritis (HP:0000123)2.11070912
99Lymphangioma (HP:0100764)2.10774018
100Renal hypoplasia (HP:0000089)2.10760964
101Medial flaring of the eyebrow (HP:0010747)2.10747393
102Abnormal platelet function (HP:0011869)2.10372676
103Impaired platelet aggregation (HP:0003540)2.10372676
104Skin nodule (HP:0200036)2.10119782
105Anterior segment dysgenesis (HP:0007700)2.08123789
106Septo-optic dysplasia (HP:0100842)2.07747705
107Hepatocellular carcinoma (HP:0001402)2.06784074
108Atrophic scars (HP:0001075)2.05839568
109Oligodactyly (hands) (HP:0001180)2.05507050
110Tubular atrophy (HP:0000092)2.04499472
111Epistaxis (HP:0000421)2.03971409
112Ulnar bowing (HP:0003031)2.02211271
113Occipital encephalocele (HP:0002085)2.00351237
114Adactyly (HP:0009776)1.99805469
115Scrotal hypoplasia (HP:0000046)1.99639983
116Mitral stenosis (HP:0001718)1.98616103
117Fibular aplasia (HP:0002990)1.98408733
118Abnormality of the labia majora (HP:0012881)1.97457673
119Furrowed tongue (HP:0000221)1.95047245
120Abnormality of transition element cation homeostasis (HP:0011030)1.94840086
121Genital tract atresia (HP:0001827)1.93776829
122Short 4th metacarpal (HP:0010044)1.93205372
123Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93205372
124Drooling (HP:0002307)1.93203204
125Goiter (HP:0000853)1.93134906
126Abnormality of glycine metabolism (HP:0010895)1.92803674
127Abnormality of serine family amino acid metabolism (HP:0010894)1.92803674
128Spontaneous hematomas (HP:0007420)1.92621679
129Coronal craniosynostosis (HP:0004440)1.91933108
130Genetic anticipation (HP:0003743)1.91593746
131Onycholysis (HP:0001806)1.91366190
132Postaxial foot polydactyly (HP:0001830)1.91199071
133Bile duct proliferation (HP:0001408)1.91184135
134Abnormal biliary tract physiology (HP:0012439)1.91184135
135Short tibia (HP:0005736)1.90999034
136Glomerulonephritis (HP:0000099)1.90093592
137Aplasia/Hypoplasia of the tongue (HP:0010295)1.89432549
138Abnormality of the nasal mucosa (HP:0000433)1.89321147
139Large for gestational age (HP:0001520)1.87912297
140Morphological abnormality of the middle ear (HP:0008609)1.87766437
141Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.87620092
142Gingivitis (HP:0000230)1.87467680
143Conjugated hyperbilirubinemia (HP:0002908)1.86915307
144Back pain (HP:0003418)1.86835261
145Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86360952
146Abolished electroretinogram (ERG) (HP:0000550)1.85912729
147Exotropia (HP:0000577)1.85478896
148Reticulocytosis (HP:0001923)1.84507203
149Obstructive lung disease (HP:0006536)1.84266712
150Chronic obstructive pulmonary disease (HP:0006510)1.84266712
151Abnormality of the ischium (HP:0003174)1.84118905
152Cerebellar dysplasia (HP:0007033)1.83591569
153Plantar hyperkeratosis (HP:0007556)1.83542497
154Hyperglycinemia (HP:0002154)1.83267406
155Fibular hypoplasia (HP:0003038)1.83191232
156Postaxial hand polydactyly (HP:0001162)1.82546264
157Labial hypoplasia (HP:0000066)1.82398453
158Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.82376238
159Vertebral hypoplasia (HP:0008417)1.82376238
160Megalencephaly (HP:0001355)1.82355581
161Abnormality of iron homeostasis (HP:0011031)1.82171892
162Disproportionate tall stature (HP:0001519)1.81815677
163Abnormal cartilage morphology (HP:0002763)1.81569388
164Vaginal atresia (HP:0000148)1.81534131
165Abnormality of fatty-acid metabolism (HP:0004359)1.80705848
166Periodontitis (HP:0000704)1.80560806
167Bifid scrotum (HP:0000048)1.80144490
168Laryngomalacia (HP:0001601)1.79418468
169Long nose (HP:0003189)1.79089277
170Pustule (HP:0200039)1.78781880
171Cutaneous syndactyly (HP:0012725)1.78660568
172Hyperbilirubinemia (HP:0002904)1.78372301
173Aplasia/Hypoplasia of the ulna (HP:0006495)1.78351835
174Joint swelling (HP:0001386)1.77926017
175Intestinal atresia (HP:0011100)1.77753940
176Polygenic inheritance (HP:0010982)1.76775164
177Aplasia/Hypoplasia of the sternum (HP:0006714)1.76760296
178Synostosis involving the elbow (HP:0003938)1.76399041
179Humeroradial synostosis (HP:0003041)1.76399041
180Abnormality of the diencephalon (HP:0010662)1.76054090
181Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.75684611
182Cerebral palsy (HP:0100021)1.75669495
183Myositis (HP:0100614)1.75175666
184Hyperglycinuria (HP:0003108)1.74714094
185Elevated erythrocyte sedimentation rate (HP:0003565)1.73399307
186Hypoplastic iliac wings (HP:0002866)1.73145221
187Abnormal gallbladder physiology (HP:0012438)1.72400543
188Cholecystitis (HP:0001082)1.72400543
189Enlarged penis (HP:0000040)1.71971592
190Stenosis of the external auditory canal (HP:0000402)1.71824063
191Anophthalmia (HP:0000528)1.69264114
192Congenital hepatic fibrosis (HP:0002612)1.68971788
193Gait imbalance (HP:0002141)1.68929647
194Malnutrition (HP:0004395)1.66796255
195Lissencephaly (HP:0001339)1.66736559
196Congenital primary aphakia (HP:0007707)1.66631189

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN25.08549475
2TRIB34.89389711
3KDR3.70135922
4ERN13.61283647
5CASK3.45035284
6PNCK3.29988010
7EPHB13.13213039
8BMPR1B2.95062200
9SIK12.85111227
10PTK62.66853412
11TNIK2.24879688
12MAPK152.24281523
13WNK32.24122847
14STK102.14803021
15ACVR1B2.13682300
16LRRK22.08748568
17TAOK32.05985655
18GRK11.88038836
19BLK1.86783172
20ADRBK21.86043560
21NTRK21.86030898
22IRAK41.83724174
23TBK11.73554245
24FGFR21.72234979
25FGFR41.71623822
26NTRK11.65251962
27EEF2K1.64253107
28WNK41.60485127
29PRKG21.60376902
30PINK11.58758068
31CSK1.55994804
32NUAK11.54934123
33BCR1.53125932
34STK391.52406967
35GRK61.48306481
36MAP4K21.43786698
37MARK11.43138740
38BMX1.43133211
39WEE11.42455871
40TYK21.35240633
41TTN1.34954291
42PTK21.34622641
43ZAK1.32212337
44MAP3K111.31317550
45STK38L1.31217515
46ALK1.29177470
47MKNK21.27868844
48PAK41.22252148
49BRSK21.19121179
50BCKDK1.15306108
51EPHA31.14551764
52FRK1.13204182
53TESK11.11149991
54MAP2K31.11115080
55ERBB21.09972183
56KSR21.09540942
57ERBB31.09161035
58MST1R1.09015740
59JAK11.06997784
60SIK21.05563409
61RIPK11.04638784
62TIE11.04050282
63PRKCE1.04030391
64TSSK61.04006354
65MAP3K41.03977769
66PLK21.02918313
67MAP3K80.99805331
68PLK40.98181719
69FES0.96836601
70MAP3K30.96512336
71JAK20.95202209
72MAPK130.94221188
73RET0.93226347
74TGFBR20.91257385
75BTK0.90702223
76CSNK1G20.86082691
77PRKCG0.85430571
78FLT30.84742755
79CAMK1G0.84049853
80MST40.83291573
81MAP4K10.83108675
82EPHA20.82101216
83ADRBK10.81557005
84PDGFRA0.80970708
85TAOK10.79946408
86OXSR10.78690213
87CDK60.77936699
88AKT30.77103283
89LIMK10.76075763
90CSNK1G10.75973806
91MAP3K100.75306790
92DAPK20.75101999
93INSRR0.74115436
94DYRK20.74050177
95PDPK10.73674785
96FGR0.73594720
97PIK3CG0.72036490
98NEK90.71900814
99MAP3K10.70534074
100ROCK10.69629042
101VRK10.67896758
102PTK2B0.67300823
103PRKAA20.66433580
104LATS10.66005318
105CDK30.65855240
106TRIM280.64695537
107MAPK40.64395170
108HCK0.64015796
109EPHA40.63767904
110IKBKE0.63676748
111STK30.62841038
112IRAK10.61743477
113ROCK20.61022410
114EGFR0.60251253
115PAK20.59378080
116MAPK110.58112077
117ZAP700.57743134
118MAP3K140.57259823
119PKN10.56468099
120FER0.56226087
121MAP2K10.56032489
122RPS6KB20.54914663
123PHKG20.54564221
124PHKG10.54564221
125SIK30.54462864
126MARK30.53625155
127PDK10.53356061
128CSNK1G30.53334902
129CSNK1A1L0.52641234
130JAK30.52200746
131IGF1R0.52059816
132CAMK1D0.51319582
133FGFR10.51056421
134LMTK20.50761812
135MET0.50720013
136NEK20.50279571
137MTOR0.50206854
138CDK120.49590766
139MAP2K40.49345202
140RIPK40.49344456
141EPHB20.49245592
142GSK3A0.48978228
143MAP2K20.48281873
144TESK20.47203619
145MKNK10.46293338
146SRC0.43961597
147ERBB40.42777292
148CAMK2A0.42561176
149NTRK30.42503675
150TGFBR10.42123271
151PLK30.41990097
152PAK30.41928640
153MAP3K20.41115175
154MAP2K70.40745064
155CLK10.39396114
156YES10.38604135
157CSNK1A10.38546055
158IRAK30.37600184
159PIM10.37494802
160MAP3K60.36107497
161CDK80.35742443
162MAP3K50.35309300
163TRPM70.35194087
164TEC0.35034805
165NEK10.34020951
166PRKCZ0.33898075
167PIK3CA0.33272649
168NLK0.31848582
169INSR0.31178618
170KSR10.27784882
171CSNK1D0.26432770
172SGK2230.26024176
173SGK4940.26024176
174SGK20.25878520
175CDK90.25309743

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.48405616
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40970631
3Nitrogen metabolism_Homo sapiens_hsa009103.01024640
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.96808946
5Complement and coagulation cascades_Homo sapiens_hsa046102.95821335
6Arginine biosynthesis_Homo sapiens_hsa002202.61741365
7Staphylococcus aureus infection_Homo sapiens_hsa051502.38199162
8Tryptophan metabolism_Homo sapiens_hsa003802.30353060
9Fatty acid degradation_Homo sapiens_hsa000712.29849287
10Linoleic acid metabolism_Homo sapiens_hsa005912.28863122
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.22850635
12Caffeine metabolism_Homo sapiens_hsa002322.14131070
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.13985203
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.12033661
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.09861461
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99577306
17Histidine metabolism_Homo sapiens_hsa003401.97709443
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89623144
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.89006569
20PPAR signaling pathway_Homo sapiens_hsa033201.87394564
21Chemical carcinogenesis_Homo sapiens_hsa052041.85863721
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.84619848
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.80816631
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80226518
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76954566
26ECM-receptor interaction_Homo sapiens_hsa045121.59841077
27Phototransduction_Homo sapiens_hsa047441.57923068
28ABC transporters_Homo sapiens_hsa020101.50936614
29Starch and sucrose metabolism_Homo sapiens_hsa005001.49587011
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48634172
31Fatty acid metabolism_Homo sapiens_hsa012121.46270292
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45884925
33beta-Alanine metabolism_Homo sapiens_hsa004101.45733556
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.41480351
35Retinol metabolism_Homo sapiens_hsa008301.40154526
36Phenylalanine metabolism_Homo sapiens_hsa003601.39790733
37Bile secretion_Homo sapiens_hsa049761.39084237
38Peroxisome_Homo sapiens_hsa041461.38869116
39Fat digestion and absorption_Homo sapiens_hsa049751.34290667
40Selenocompound metabolism_Homo sapiens_hsa004501.33010946
41Protein export_Homo sapiens_hsa030601.29927695
42Butanoate metabolism_Homo sapiens_hsa006501.28360384
43Ether lipid metabolism_Homo sapiens_hsa005651.27164560
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26378723
45Axon guidance_Homo sapiens_hsa043601.24445443
46Biosynthesis of amino acids_Homo sapiens_hsa012301.23151237
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20267406
48Sulfur metabolism_Homo sapiens_hsa009201.19035729
49Basal cell carcinoma_Homo sapiens_hsa052171.18521060
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13575480
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11694510
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11252055
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09645412
54Pentose phosphate pathway_Homo sapiens_hsa000301.09444684
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09408510
56Nicotine addiction_Homo sapiens_hsa050331.08985217
57Propanoate metabolism_Homo sapiens_hsa006401.08639904
58Carbon metabolism_Homo sapiens_hsa012001.06942027
59Arachidonic acid metabolism_Homo sapiens_hsa005901.05542696
60Hedgehog signaling pathway_Homo sapiens_hsa043401.04928312
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01711297
62Tyrosine metabolism_Homo sapiens_hsa003501.00511038
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98436087
64Thyroid hormone synthesis_Homo sapiens_hsa049180.97775846
65Pyruvate metabolism_Homo sapiens_hsa006200.97076051
66Hippo signaling pathway_Homo sapiens_hsa043900.96680582
67TGF-beta signaling pathway_Homo sapiens_hsa043500.96658835
68Leishmaniasis_Homo sapiens_hsa051400.95445930
69Dorso-ventral axis formation_Homo sapiens_hsa043200.93704790
70Lysine degradation_Homo sapiens_hsa003100.90945112
71Steroid biosynthesis_Homo sapiens_hsa001000.90163373
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.90043246
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88647464
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87275749
75Vitamin digestion and absorption_Homo sapiens_hsa049770.87036497
76Glutathione metabolism_Homo sapiens_hsa004800.86157941
77Sulfur relay system_Homo sapiens_hsa041220.84032120
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.83097172
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.81097642
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77078021
81Serotonergic synapse_Homo sapiens_hsa047260.74728218
82Protein digestion and absorption_Homo sapiens_hsa049740.74553244
83One carbon pool by folate_Homo sapiens_hsa006700.73541813
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70490415
85Arginine and proline metabolism_Homo sapiens_hsa003300.65674384
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64481635
87Osteoclast differentiation_Homo sapiens_hsa043800.64245069
88Glutamatergic synapse_Homo sapiens_hsa047240.63247495
89Insulin resistance_Homo sapiens_hsa049310.62493308
90Amoebiasis_Homo sapiens_hsa051460.62480917
91Asthma_Homo sapiens_hsa053100.61686296
92* Glycerolipid metabolism_Homo sapiens_hsa005610.59415306
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58213404
94Malaria_Homo sapiens_hsa051440.53677593
95Taste transduction_Homo sapiens_hsa047420.53025634
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51633142
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.51005068
98Fatty acid elongation_Homo sapiens_hsa000620.50732426
99Cocaine addiction_Homo sapiens_hsa050300.49724878
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.49447746
101Basal transcription factors_Homo sapiens_hsa030220.49209888
102Galactose metabolism_Homo sapiens_hsa000520.48723905
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47164168
104* Metabolic pathways_Homo sapiens_hsa011000.46945548
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46434567
106Insulin secretion_Homo sapiens_hsa049110.46321369
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.45913423
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45452271
109Ovarian steroidogenesis_Homo sapiens_hsa049130.44860995
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44610399
111Circadian entrainment_Homo sapiens_hsa047130.44551780
112Toxoplasmosis_Homo sapiens_hsa051450.44080095
113Tight junction_Homo sapiens_hsa045300.44030368
114GABAergic synapse_Homo sapiens_hsa047270.43678334
115Pertussis_Homo sapiens_hsa051330.42210874
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41278244
117Fatty acid biosynthesis_Homo sapiens_hsa000610.41248588
118Morphine addiction_Homo sapiens_hsa050320.41108698
119Folate biosynthesis_Homo sapiens_hsa007900.37716887
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37521993
121Bladder cancer_Homo sapiens_hsa052190.36107595
122TNF signaling pathway_Homo sapiens_hsa046680.35819316
123Mineral absorption_Homo sapiens_hsa049780.35428723
124Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35377077
125Legionellosis_Homo sapiens_hsa051340.34825305
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33948267
127Sphingolipid metabolism_Homo sapiens_hsa006000.33917108
128African trypanosomiasis_Homo sapiens_hsa051430.33578969
129Olfactory transduction_Homo sapiens_hsa047400.33575778
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33238873
131Vitamin B6 metabolism_Homo sapiens_hsa007500.33227539
132Small cell lung cancer_Homo sapiens_hsa052220.32825746
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32286645
134Phagosome_Homo sapiens_hsa041450.31610006
135Fructose and mannose metabolism_Homo sapiens_hsa000510.31543492
136Acute myeloid leukemia_Homo sapiens_hsa052210.30833943
137Hepatitis C_Homo sapiens_hsa051600.30486179
138VEGF signaling pathway_Homo sapiens_hsa043700.30247778
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.29524751
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28380035
141Adherens junction_Homo sapiens_hsa045200.27563989
142Proteoglycans in cancer_Homo sapiens_hsa052050.24260207
143AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23482004
144Focal adhesion_Homo sapiens_hsa045100.23074739
145Tuberculosis_Homo sapiens_hsa051520.22986627
146Prion diseases_Homo sapiens_hsa050200.22865664
147Lysosome_Homo sapiens_hsa041420.21043162
148Influenza A_Homo sapiens_hsa051640.20926778
149HIF-1 signaling pathway_Homo sapiens_hsa040660.18792680

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