LIPH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.89831517
2intestinal epithelial cell development (GO:0060576)5.88965317
3regulation of posttranscriptional gene silencing (GO:0060147)5.27238999
4regulation of gene silencing by miRNA (GO:0060964)5.27238999
5regulation of gene silencing by RNA (GO:0060966)5.27238999
6water-soluble vitamin biosynthetic process (GO:0042364)4.45085307
7determination of adult lifespan (GO:0008340)4.41946299
8bundle of His cell to Purkinje myocyte communication (GO:0086069)4.40779552
9regulation of chemokine secretion (GO:0090196)4.29748483
10sulfation (GO:0051923)4.29375538
11trophectodermal cell differentiation (GO:0001829)4.21843492
12fucose catabolic process (GO:0019317)4.11495930
13L-fucose metabolic process (GO:0042354)4.11495930
14L-fucose catabolic process (GO:0042355)4.11495930
15desmosome organization (GO:0002934)4.06426212
16interferon-gamma secretion (GO:0072643)3.98853386
17embryonic process involved in female pregnancy (GO:0060136)3.90677519
18somatic hypermutation of immunoglobulin genes (GO:0016446)3.86484666
19somatic diversification of immune receptors via somatic mutation (GO:0002566)3.86484666
20DNA deamination (GO:0045006)3.82746796
21regulation of water loss via skin (GO:0033561)3.71156092
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.68283460
23calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.67512847
24purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.52341127
253-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.52341127
26establishment of skin barrier (GO:0061436)3.48688494
27regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.45939556
28establishment of apical/basal cell polarity (GO:0035089)3.41685390
29epithelial cilium movement (GO:0003351)3.40718663
30regulation of hippo signaling (GO:0035330)3.38284936
31intestinal absorption (GO:0050892)3.37082068
32parturition (GO:0007567)3.37080269
33purine nucleobase biosynthetic process (GO:0009113)3.36010174
34hepatocyte apoptotic process (GO:0097284)3.34973755
35axonemal dynein complex assembly (GO:0070286)3.33660320
36regulation of helicase activity (GO:0051095)3.32935955
37membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.32924095
38axoneme assembly (GO:0035082)3.32894651
39indolalkylamine metabolic process (GO:0006586)3.31292582
40maintenance of gastrointestinal epithelium (GO:0030277)3.28505792
41protein complex biogenesis (GO:0070271)3.27837787
42magnesium ion transport (GO:0015693)3.26850197
43cell differentiation involved in embryonic placenta development (GO:0060706)3.25849967
44branching involved in labyrinthine layer morphogenesis (GO:0060670)3.25275254
45cilium movement (GO:0003341)3.25130950
46positive regulation of fatty acid oxidation (GO:0046321)3.21166112
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.20072120
48mitochondrial respiratory chain complex I assembly (GO:0032981)3.20072120
49NADH dehydrogenase complex assembly (GO:0010257)3.20072120
50phosphatidylinositol acyl-chain remodeling (GO:0036149)3.19412485
51nucleobase biosynthetic process (GO:0046112)3.16681032
52UDP-N-acetylglucosamine metabolic process (GO:0006047)3.16514710
53negative regulation of T cell differentiation in thymus (GO:0033085)3.15124479
54regulation of nuclear cell cycle DNA replication (GO:0033262)3.14087673
55surfactant homeostasis (GO:0043129)3.13225233
56tryptophan catabolic process (GO:0006569)3.12541081
57indole-containing compound catabolic process (GO:0042436)3.12541081
58indolalkylamine catabolic process (GO:0046218)3.12541081
59proline biosynthetic process (GO:0006561)3.10638541
60anterior/posterior axis specification, embryo (GO:0008595)3.07584167
61phosphatidylserine acyl-chain remodeling (GO:0036150)3.06763478
62membrane repolarization during action potential (GO:0086011)3.06327359
63flavonoid metabolic process (GO:0009812)3.04196846
64kynurenine metabolic process (GO:0070189)3.01198371
65positive regulation of SMAD protein import into nucleus (GO:0060391)3.01118688
66nuclear pore organization (GO:0006999)3.00251224
67angiotensin maturation (GO:0002003)3.00199455
68positive regulation of fatty acid beta-oxidation (GO:0032000)2.98722756
69histone H4-K12 acetylation (GO:0043983)2.97032326
70keratinocyte development (GO:0003334)2.96843227
71protein neddylation (GO:0045116)2.96436399
72kidney morphogenesis (GO:0060993)2.96171474
73formation of translation preinitiation complex (GO:0001731)2.95320725
74nodal signaling pathway (GO:0038092)2.93034967
75DNA replication initiation (GO:0006270)2.92037021
76GDP-mannose metabolic process (GO:0019673)2.91598955
77establishment of monopolar cell polarity (GO:0061162)2.91329673
78establishment or maintenance of monopolar cell polarity (GO:0061339)2.91329673
79mitochondrial respiratory chain complex assembly (GO:0033108)2.90273758
80negative regulation of appetite (GO:0032099)2.86916279
81negative regulation of response to food (GO:0032096)2.86916279
82cobalamin metabolic process (GO:0009235)2.86858524
83regulation of mesoderm development (GO:2000380)2.84444042
84cellular response to ATP (GO:0071318)2.83217236
85regulation of gene silencing (GO:0060968)2.82161939
86signal transduction involved in regulation of gene expression (GO:0023019)2.80984773
87peptide catabolic process (GO:0043171)2.78842081
88replication fork processing (GO:0031297)2.78298379
89phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.78026984
90cellular anion homeostasis (GO:0030002)2.77774629
91drug catabolic process (GO:0042737)2.77565383
92thyroid hormone metabolic process (GO:0042403)2.77419239
93cyclooxygenase pathway (GO:0019371)2.76622429
94IMP biosynthetic process (GO:0006188)2.75645707
95positive regulation of fatty acid transport (GO:2000193)2.73417789
96sphingoid metabolic process (GO:0046519)2.72648790
97hemidesmosome assembly (GO:0031581)2.72558611
98multicellular organism reproduction (GO:0032504)2.72495550
99regulation of cilium movement (GO:0003352)2.71756395
100cell proliferation in forebrain (GO:0021846)2.71020665
101membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.71016785
102protein polyglutamylation (GO:0018095)2.70835555
103multicellular organismal water homeostasis (GO:0050891)2.70267632
104regulation of glomerulus development (GO:0090192)2.70134862
105nuclear pore complex assembly (GO:0051292)2.69635750
106branching involved in mammary gland duct morphogenesis (GO:0060444)2.69502300
107DNA strand elongation involved in DNA replication (GO:0006271)2.67676696
108detection of light stimulus involved in sensory perception (GO:0050962)2.66869446
109detection of light stimulus involved in visual perception (GO:0050908)2.66869446
110replicative senescence (GO:0090399)2.66696446
111negative regulation of systemic arterial blood pressure (GO:0003085)2.66254730
112negative regulation of keratinocyte proliferation (GO:0010839)2.66242498
113amine catabolic process (GO:0009310)2.65891025
114cellular biogenic amine catabolic process (GO:0042402)2.65891025
115mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.65802488
116intestinal cholesterol absorption (GO:0030299)2.65633782
117pyrimidine-containing compound transmembrane transport (GO:0072531)2.65621136
118somite development (GO:0061053)2.65299225
119lung secretory cell differentiation (GO:0061140)2.64815167
120nucleotide-sugar biosynthetic process (GO:0009226)2.64390851
121protein K6-linked ubiquitination (GO:0085020)2.63003260
122diol metabolic process (GO:0034311)2.62272650
123notochord development (GO:0030903)2.61710983
124positive regulation of respiratory burst (GO:0060267)2.61277580
125maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.61083201
126platelet dense granule organization (GO:0060155)2.60555278
127indole-containing compound metabolic process (GO:0042430)2.60446248
128negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.60281411
129telomere maintenance via semi-conservative replication (GO:0032201)2.60028998
130preassembly of GPI anchor in ER membrane (GO:0016254)2.59909022
131primary amino compound metabolic process (GO:1901160)2.58434145
132columnar/cuboidal epithelial cell development (GO:0002066)2.57740425
133serotonin metabolic process (GO:0042428)2.57348843
134positive regulation of chemokine secretion (GO:0090197)2.57322284
135regulation of memory T cell differentiation (GO:0043380)2.55979074
136paraxial mesoderm development (GO:0048339)2.55603184
137cilium or flagellum-dependent cell motility (GO:0001539)2.55478822
138DNA strand elongation (GO:0022616)2.54895556
139tryptophan metabolic process (GO:0006568)2.54399126
140benzene-containing compound metabolic process (GO:0042537)2.53985607
141sphingosine metabolic process (GO:0006670)2.53567314
142chemical homeostasis within a tissue (GO:0048875)2.53027668
143ribosome assembly (GO:0042255)2.52876821
144vitamin A metabolic process (GO:0006776)2.52829324
145tight junction assembly (GO:0070830)2.52163896
146sulfate transport (GO:0008272)2.50864087
147digestion (GO:0007586)2.50561613
148regulation of SMAD protein import into nucleus (GO:0060390)2.50528293
149exogenous drug catabolic process (GO:0042738)2.50374845
150regulation of telomere maintenance via telomerase (GO:0032210)2.50269614
151adaptation of signaling pathway (GO:0023058)2.48284996
152negative regulation by host of viral transcription (GO:0043922)2.48155611
153sulfate transmembrane transport (GO:1902358)2.47866444
154negative regulation of gene silencing (GO:0060969)2.47595228
155energy coupled proton transport, down electrochemical gradient (GO:0015985)2.47488311
156ATP synthesis coupled proton transport (GO:0015986)2.47488311
157negative regulation of transcription regulatory region DNA binding (GO:2000678)2.47065596
158transepithelial transport (GO:0070633)2.46762956
159regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.46697370
160dopamine transport (GO:0015872)2.46268234
161mitotic nuclear envelope disassembly (GO:0007077)2.44350695
162positive regulation of icosanoid secretion (GO:0032305)2.44169485
163regulation of integrin activation (GO:0033623)2.44041561
164vitamin biosynthetic process (GO:0009110)2.43829668
165cellular ketone body metabolic process (GO:0046950)2.43828158
166regulation of action potential (GO:0098900)2.43610326
167regulation of translation in response to stress (GO:0043555)2.42686354
168neuronal action potential (GO:0019228)2.42416671
169bicarbonate transport (GO:0015701)2.42270850
170regulation of double-strand break repair via homologous recombination (GO:0010569)2.41428189
171pharyngeal system development (GO:0060037)2.41154998
172nucleotide transmembrane transport (GO:1901679)2.40841714
173heterochromatin organization (GO:0070828)2.40748862
174phosphatidylcholine acyl-chain remodeling (GO:0036151)2.40115727
175phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.39189934
176telomere maintenance via recombination (GO:0000722)2.38235188
177ribosome biogenesis (GO:0042254)2.37911250
178cytidine metabolic process (GO:0046087)2.37769564
179cytidine catabolic process (GO:0006216)2.37769564
180cytidine deamination (GO:0009972)2.37769564
181positive regulation of defense response to virus by host (GO:0002230)2.37529855
182regulation of translational fidelity (GO:0006450)2.37149438
183endoderm formation (GO:0001706)2.37117422
184positive regulation of prostaglandin secretion (GO:0032308)2.36870974
185telomere maintenance via telomere lengthening (GO:0010833)2.36370325
186endocrine pancreas development (GO:0031018)2.34350514
187vitamin transmembrane transport (GO:0035461)2.32463419
188positive regulation of mitotic sister chromatid separation (GO:1901970)2.31894634
189positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.31894634
190positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.31894634
191DNA strand renaturation (GO:0000733)2.31010421
192pore complex assembly (GO:0046931)2.30736388
193DNA geometric change (GO:0032392)2.29936644
194positive regulation of epidermal cell differentiation (GO:0045606)2.28872097
195embryonic placenta development (GO:0001892)2.28676685
196positive regulation of interleukin-8 secretion (GO:2000484)2.28661147
197DNA duplex unwinding (GO:0032508)2.27437154
198placenta development (GO:0001890)2.27362645

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.49358721
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.01937389
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.18464060
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.18464060
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.18464060
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.31517063
7VDR_22108803_ChIP-Seq_LS180_Human3.09004041
8POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.04470990
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.99581175
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.79974924
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.79659276
12ZNF274_21170338_ChIP-Seq_K562_Hela2.60406216
13* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.57758435
14TCF3_18692474_ChIP-Seq_MEFs_Mouse2.57588178
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.43725969
16TCF3_18692474_ChIP-Seq_MESCs_Mouse2.36188872
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.30188568
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.30151301
19* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.25298428
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.24377730
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21719228
22GBX2_23144817_ChIP-Seq_PC3_Human2.21600658
23EZH2_22144423_ChIP-Seq_EOC_Human2.16999116
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15484305
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14768634
26* STAT3_1855785_ChIP-Seq_MESCs_Mouse2.14443027
27* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.12058517
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09887700
29* NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.09208248
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.99642572
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97621535
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96788727
33KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.96503863
34* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.92905138
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.87911890
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.86616927
37CDX2_20551321_ChIP-Seq_CACO-2_Human1.85069867
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.80780748
39SOX2_18555785_ChIP-Seq_MESCs_Mouse1.79175622
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.77547105
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76336603
42* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.74408536
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71591966
44NANOG_18692474_ChIP-Seq_MEFs_Mouse1.65091886
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.64629482
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.60962756
47ER_23166858_ChIP-Seq_MCF-7_Human1.60248339
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.60113865
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58543809
50AR_21909140_ChIP-Seq_LNCAP_Human1.57690127
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.57397687
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.56074356
53* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.55750829
54SOX2_18692474_ChIP-Seq_MEFs_Mouse1.55167332
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55140213
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54718975
57* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.54660908
58* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54176447
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52955495
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.52292335
61* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52046850
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50832605
63BCAT_22108803_ChIP-Seq_LS180_Human1.50672040
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50661377
65* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.50255229
66EWS_26573619_Chip-Seq_HEK293_Human1.50210127
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49307708
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.48461170
69P300_19829295_ChIP-Seq_ESCs_Human1.47697248
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46430777
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.46430777
72* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46137342
73* GATA6_25053715_ChIP-Seq_YYC3_Human1.43483206
74FUS_26573619_Chip-Seq_HEK293_Human1.42168049
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41821507
76* GATA4_25053715_ChIP-Seq_YYC3_Human1.41093326
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.40850405
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40573315
79* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36926261
80MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36823047
81OCT4_18692474_ChIP-Seq_MEFs_Mouse1.34991213
82GATA3_21878914_ChIP-Seq_MCF-7_Human1.33867542
83KAP1_27257070_Chip-Seq_ESCs_Mouse1.33692286
84* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.33311415
85TDRD3_21172665_ChIP-Seq_MCF-7_Human1.33272647
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31272976
87TAF15_26573619_Chip-Seq_HEK293_Human1.29166142
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28955232
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28507171
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27522700
91E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27421279
92* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.27080733
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27035957
94RNF2_27304074_Chip-Seq_NSC_Mouse1.26894536
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25535247
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25235242
97EZH2_27294783_Chip-Seq_ESCs_Mouse1.24602631
98CDX2_22108803_ChIP-Seq_LS180_Human1.24302689
99AR_25329375_ChIP-Seq_VCAP_Human1.24259080
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24201910
101AR_20517297_ChIP-Seq_VCAP_Human1.23447602
102AHR_22903824_ChIP-Seq_MCF-7_Human1.23436971
103POU5F1_16518401_ChIP-PET_MESCs_Mouse1.23134344
104CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23119956
105NCOR_22424771_ChIP-Seq_293T_Human1.22485154
106JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22288424
107SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21413929
108ARNT_22903824_ChIP-Seq_MCF-7_Human1.21018768
109* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.20928934
110TCF4_22108803_ChIP-Seq_LS180_Human1.20466534
111AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20220454
112SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19960427
113EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.19847407
114CBP_20019798_ChIP-Seq_JUKART_Human1.19544234
115IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19544234
116HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19123656
117HOXB7_26014856_ChIP-Seq_BT474_Human1.17656262
118JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17537899
119FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17267049
120FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17109537
121NANOG_19829295_ChIP-Seq_ESCs_Human1.16800991
122SOX2_19829295_ChIP-Seq_ESCs_Human1.16800991
123* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.16776715
124HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16627343
125KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13687276
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13574534
127TP53_22573176_ChIP-Seq_HFKS_Human1.13556180
128PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13337182
129* SMAD4_21799915_ChIP-Seq_A2780_Human1.13207350
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13039442
131ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12955757
132SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12922611
133E2F1_21310950_ChIP-Seq_MCF-7_Human1.12886366
134SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11730410
135SMAD4_21741376_ChIP-Seq_EPCs_Human1.11352130
136STAT3_23295773_ChIP-Seq_U87_Human1.11145882
137IGF1R_20145208_ChIP-Seq_DFB_Human1.10620332
138AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10363271
139TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10186475
140SOX2_20726797_ChIP-Seq_SW620_Human1.10046676
141PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.09100518
142STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08695746
143NFE2_27457419_Chip-Seq_LIVER_Mouse1.08497755
144CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07628990
145TAF2_19829295_ChIP-Seq_ESCs_Human1.06810803
146SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06753892
147* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06721537
148MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06531895
149TCF4_23295773_ChIP-Seq_U87_Human1.06136467
150KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05752232
151PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05571543
152REST_21632747_ChIP-Seq_MESCs_Mouse1.03534437
153ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02498703
154KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02406282
155YY1_21170310_ChIP-Seq_MESCs_Mouse1.01837140
156GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01821976
157SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01677901
158SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01677901
159ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00668684
160MYC_18940864_ChIP-ChIP_HL60_Human1.00635309
161KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00541109
162NANOG_20526341_ChIP-Seq_ESCs_Human1.00345666
163SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99745822
164PRDM14_20953172_ChIP-Seq_ESCs_Human0.99265983
165EZH2_27304074_Chip-Seq_ESCs_Mouse0.99231180
166ERA_21632823_ChIP-Seq_H3396_Human0.97805454
167BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97799834
168KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97795847
169CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97667467
170SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96469812
171ESR2_21235772_ChIP-Seq_MCF-7_Human0.95673293
172MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94916437
173NANOG_21062744_ChIP-ChIP_HESCs_Human0.94775366
174CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94500781
175* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94187231
176NANOG_16518401_ChIP-PET_MESCs_Mouse0.93115016
177JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.90793148
178MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.88629399
179IRF1_19129219_ChIP-ChIP_H3396_Human0.87903350
180P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87602934
181RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87262863
182TP63_19390658_ChIP-ChIP_HaCaT_Human0.87113232
183EST1_17652178_ChIP-ChIP_JURKAT_Human0.86721441
184* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85122278
185NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.85069196
186RUNX1_27514584_Chip-Seq_MCF-7_Human0.83856452
187ATF3_27146783_Chip-Seq_COLON_Human0.83104951
188FOXO3_23340844_ChIP-Seq_DLD1_Human0.82303413
189STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81798090
190ETS1_20019798_ChIP-Seq_JURKAT_Human0.80228464
191HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78990452
192* GATA3_24758297_ChIP-Seq_MCF-7_Human0.78946483
193* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78766208

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.40217862
2MP0004264_abnormal_extraembryonic_tissu3.63895911
3MP0002876_abnormal_thyroid_physiology3.25702025
4MP0010352_gastrointestinal_tract_polyps3.24812651
5MP0003941_abnormal_skin_development3.14612444
6MP0008004_abnormal_stomach_pH2.91279668
7MP0008875_abnormal_xenobiotic_pharmacok2.91238202
8MP0002796_impaired_skin_barrier2.78359530
9MP0001873_stomach_inflammation2.75239882
10MP0004782_abnormal_surfactant_physiolog2.69549101
11MP0005646_abnormal_pituitary_gland2.61653568
12MP0003693_abnormal_embryo_hatching2.59201256
13MP0008872_abnormal_physiological_respon2.52150439
14MP0008057_abnormal_DNA_replication2.40937345
15MP0004957_abnormal_blastocyst_morpholog2.38186020
16MP0002254_reproductive_system_inflammat2.33268260
17MP0000490_abnormal_crypts_of2.28337181
18MP0005367_renal/urinary_system_phenotyp2.20082622
19MP0000516_abnormal_urinary_system2.20082622
20MP0003195_calcinosis2.16979053
21MP0002138_abnormal_hepatobiliary_system2.16226532
22MP0009379_abnormal_foot_pigmentation2.16133799
23MP0005501_abnormal_skin_physiology2.15163706
24MP0002277_abnormal_respiratory_mucosa2.13346287
25MP0004043_abnormal_pH_regulation2.12655979
26MP0003453_abnormal_keratinocyte_physiol2.10251939
27MP0003011_delayed_dark_adaptation2.08899281
28MP0001485_abnormal_pinna_reflex2.05951168
29MP0002160_abnormal_reproductive_system2.03046724
30MP0005085_abnormal_gallbladder_physiolo2.02834844
31MP0010094_abnormal_chromosome_stability2.00791114
32MP0003111_abnormal_nucleus_morphology1.99082567
33MP0000537_abnormal_urethra_morphology1.93532341
34MP0004885_abnormal_endolymph1.91127080
35MP0005551_abnormal_eye_electrophysiolog1.89490644
36MP0002837_dystrophic_cardiac_calcinosis1.85513071
37MP0003646_muscle_fatigue1.83059332
38MP0010386_abnormal_urinary_bladder1.83028349
39MP0005083_abnormal_biliary_tract1.81331665
40MP0003566_abnormal_cell_adhesion1.74986531
41MP0005389_reproductive_system_phenotype1.74420004
42MP0001765_abnormal_ion_homeostasis1.73165199
43MP0002098_abnormal_vibrissa_morphology1.73138153
44MP0003718_maternal_effect1.69047517
45MP0005365_abnormal_bile_salt1.68275242
46MP0008058_abnormal_DNA_repair1.67144561
47MP0003077_abnormal_cell_cycle1.64915966
48MP0003283_abnormal_digestive_organ1.63908633
49MP0010678_abnormal_skin_adnexa1.60209807
50MP0000631_abnormal_neuroendocrine_gland1.59007166
51MP0008877_abnormal_DNA_methylation1.56435324
52MP0005360_urolithiasis1.55339058
53MP0000566_synostosis1.53343970
54MP0005076_abnormal_cell_differentiation1.53203893
55MP0006292_abnormal_olfactory_placode1.52746517
56MP0001666_abnormal_nutrient_absorption1.52496853
57MP0002139_abnormal_hepatobiliary_system1.52332937
58MP0002653_abnormal_ependyma_morphology1.47755801
59MP0000477_abnormal_intestine_morphology1.47621608
60MP0003890_abnormal_embryonic-extraembry1.46736322
61MP0001968_abnormal_touch/_nociception1.45988564
62MP0005670_abnormal_white_adipose1.43484545
63MP0001216_abnormal_epidermal_layer1.42473353
64MP0006072_abnormal_retinal_apoptosis1.40364002
65MP0000470_abnormal_stomach_morphology1.39327502
66MP0005310_abnormal_salivary_gland1.38350618
67MP0002736_abnormal_nociception_after1.37795140
68MP0010155_abnormal_intestine_physiology1.37569190
69MP0000350_abnormal_cell_proliferation1.34652971
70MP0000230_abnormal_systemic_arterial1.34145206
71MP0004147_increased_porphyrin_level1.33864412
72MP0005645_abnormal_hypothalamus_physiol1.28221693
73MP0002163_abnormal_gland_morphology1.28099784
74MP0002086_abnormal_extraembryonic_tissu1.28000076
75MP0009745_abnormal_behavioral_response1.27698149
76MP0000462_abnormal_digestive_system1.27568924
77MP0002009_preneoplasia1.26842507
78MP0001919_abnormal_reproductive_system1.26790844
79MP0005084_abnormal_gallbladder_morpholo1.26786092
80MP0005332_abnormal_amino_acid1.26570683
81MP0002272_abnormal_nervous_system1.25499060
82MP0003786_premature_aging1.25336527
83MP0002102_abnormal_ear_morphology1.23884110
84MP0001905_abnormal_dopamine_level1.23312992
85MP0000383_abnormal_hair_follicle1.23198166
86MP0004142_abnormal_muscle_tone1.21962492
87MP0002132_abnormal_respiratory_system1.21556649
88MP0005023_abnormal_wound_healing1.21530774
89MP0009780_abnormal_chondrocyte_physiolo1.20858792
90MP0003252_abnormal_bile_duct1.20348898
91MP0003879_abnormal_hair_cell1.19545326
92MP0003806_abnormal_nucleotide_metabolis1.17642196
93MP0010307_abnormal_tumor_latency1.17636853
94MP0008775_abnormal_heart_ventricle1.15378666
95MP0003638_abnormal_response/metabolism_1.14718330
96MP0000627_abnormal_mammary_gland1.14647435
97MP0002909_abnormal_adrenal_gland1.14397352
98MP0004947_skin_inflammation1.14267927
99MP0005636_abnormal_mineral_homeostasis1.13573757
100MP0002638_abnormal_pupillary_reflex1.13084371
101MP0003119_abnormal_digestive_system1.13012595
102MP0008007_abnormal_cellular_replicative1.12630713
103MP0010329_abnormal_lipoprotein_level1.12141777
104MP0001502_abnormal_circadian_rhythm1.12107156
105MP0003315_abnormal_perineum_morphology1.10641151
106MP0001756_abnormal_urination1.10300539
107MP0001664_abnormal_digestion1.10178835
108MP0001672_abnormal_embryogenesis/_devel1.08991216
109MP0005380_embryogenesis_phenotype1.08991216
110MP0002733_abnormal_thermal_nociception1.07381031
111MP0001730_embryonic_growth_arrest1.07378393
112MP0001986_abnormal_taste_sensitivity1.06756494
113MP0002735_abnormal_chemical_nociception1.06129821
114MP0003787_abnormal_imprinting1.06119997
115MP0004133_heterotaxia1.05644623
116MP0009046_muscle_twitch1.05550857
117MP0000427_abnormal_hair_cycle1.05507378
118MP0000049_abnormal_middle_ear1.05474075
119MP0001663_abnormal_digestive_system1.04477174
120MP0001970_abnormal_pain_threshold1.04070416
121MP0004145_abnormal_muscle_electrophysio1.03969001
122MP0005253_abnormal_eye_physiology1.03640316
123MP0001501_abnormal_sleep_pattern1.02692584
124MP0003136_yellow_coat_color1.02451124
125MP0002060_abnormal_skin_morphology1.01556292
126MP0003705_abnormal_hypodermis_morpholog1.01193827
127MP0001440_abnormal_grooming_behavior1.01044264
128MP0000467_abnormal_esophagus_morphology1.00120629
129MP0006276_abnormal_autonomic_nervous0.99030558
130MP0003878_abnormal_ear_physiology0.98533507
131MP0005377_hearing/vestibular/ear_phenot0.98533507
132MP0005381_digestive/alimentary_phenotyp0.97682522
133MP0000538_abnormal_urinary_bladder0.97440907
134MP0008995_early_reproductive_senescence0.97238809
135MP0004197_abnormal_fetal_growth/weight/0.96976889
136MP0002928_abnormal_bile_duct0.95758746
137MP0000762_abnormal_tongue_morphology0.95663866
138MP0002693_abnormal_pancreas_physiology0.95149269
139MP0006054_spinal_hemorrhage0.95137700
140MP0002085_abnormal_embryonic_tissue0.94865606
141MP0006082_CNS_inflammation0.94819098
142MP0009643_abnormal_urine_homeostasis0.93619621
143MP0000026_abnormal_inner_ear0.93491588
144MP0000377_abnormal_hair_follicle0.92738129
145MP0003938_abnormal_ear_development0.91671424
146MP0001697_abnormal_embryo_size0.91393716
147MP0004130_abnormal_muscle_cell0.91355136
148MP0003984_embryonic_growth_retardation0.91180458
149MP0008932_abnormal_embryonic_tissue0.90528201
150MP0001346_abnormal_lacrimal_gland0.90165385
151MP0003866_abnormal_defecation0.88826058
152MP0002088_abnormal_embryonic_growth/wei0.88122645
153MP0010030_abnormal_orbit_morphology0.87840445
154MP0002084_abnormal_developmental_patter0.87793669
155MP0009053_abnormal_anal_canal0.87541824
156MP0003724_increased_susceptibility_to0.87238162
157MP0002136_abnormal_kidney_physiology0.86683177
158MP0001881_abnormal_mammary_gland0.86481150
159MP0002557_abnormal_social/conspecific_i0.86436749
160MP0000465_gastrointestinal_hemorrhage0.86185796
161MP0000678_abnormal_parathyroid_gland0.86094487
162MP0003123_paternal_imprinting0.85252559
163MP0010771_integument_phenotype0.84839579
164MP0002938_white_spotting0.84761709
165MP0001944_abnormal_pancreas_morphology0.84565818
166MP0003953_abnormal_hormone_level0.83844048
167MP0003183_abnormal_peptide_metabolism0.83626708
168MP0004185_abnormal_adipocyte_glucose0.83031316
169MP0005195_abnormal_posterior_eye0.82330460
170MP0004742_abnormal_vestibular_system0.81164137
171MP0004215_abnormal_myocardial_fiber0.81096933
172MP0001293_anophthalmia0.78540912
173MP0002019_abnormal_tumor_incidence0.78308432
174MP0001849_ear_inflammation0.77757707
175MP0000613_abnormal_salivary_gland0.76726477
176MP0003936_abnormal_reproductive_system0.75149774
177MP0000579_abnormal_nail_morphology0.75071597
178MP0004019_abnormal_vitamin_homeostasis0.73796284
179MP0002148_abnormal_hypersensitivity_rea0.73632107
180MP0005275_abnormal_skin_tensile0.72633999
181MP0002080_prenatal_lethality0.72227956
182MP0002396_abnormal_hematopoietic_system0.72049417
183MP0003191_abnormal_cellular_cholesterol0.71671503
184MP0002111_abnormal_tail_morphology0.71150110

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)4.79831919
2Pancreatic cysts (HP:0001737)3.77213004
3True hermaphroditism (HP:0010459)3.46531684
4Decreased circulating renin level (HP:0003351)3.40609631
5Pancreatic fibrosis (HP:0100732)3.38726593
6Congenital stationary night blindness (HP:0007642)3.38252533
7Pustule (HP:0200039)3.34532849
8Biliary tract neoplasm (HP:0100574)3.32637897
9Abnormal respiratory motile cilium morphology (HP:0005938)3.28746813
10Abnormal respiratory epithelium morphology (HP:0012253)3.28746813
11Breast hypoplasia (HP:0003187)3.28317320
12Absent/shortened dynein arms (HP:0200106)3.22443228
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.22443228
14Molar tooth sign on MRI (HP:0002419)3.22435581
15Abnormality of midbrain morphology (HP:0002418)3.22435581
16Chromsome breakage (HP:0040012)3.20876105
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.19429697
18Agnosia (HP:0010524)3.18184038
19Pili torti (HP:0003777)3.13644462
20Abnormality of the renal cortex (HP:0011035)3.12860874
21Abnormal ciliary motility (HP:0012262)3.12227657
22Lip pit (HP:0100267)3.05991293
23Nephronophthisis (HP:0000090)3.01525458
24Pendular nystagmus (HP:0012043)3.01262264
25Abolished electroretinogram (ERG) (HP:0000550)2.97787004
26Onycholysis (HP:0001806)2.95407348
27Abnormal respiratory motile cilium physiology (HP:0012261)2.95106971
28Curly hair (HP:0002212)2.93240139
29Tubular atrophy (HP:0000092)2.92271033
30Absent radius (HP:0003974)2.90981057
31Ependymoma (HP:0002888)2.88389027
32Abnormality of renin-angiotensin system (HP:0000847)2.84392526
33Congenital sensorineural hearing impairment (HP:0008527)2.82543303
34Abnormality of the renal medulla (HP:0100957)2.81311736
35Congenital ichthyosiform erythroderma (HP:0007431)2.78052466
36Prostate neoplasm (HP:0100787)2.77707694
37Shawl scrotum (HP:0000049)2.77055976
38Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.74365254
39Abnormality of the labia minora (HP:0012880)2.73309912
40Esophageal atresia (HP:0002032)2.72770576
41Aplasia involving forearm bones (HP:0009822)2.71887532
42Absent forearm bone (HP:0003953)2.71887532
43Hyperactive renin-angiotensin system (HP:0000841)2.69612061
44Abnormal biliary tract morphology (HP:0012440)2.67954535
45Metabolic alkalosis (HP:0200114)2.67329811
46Rhinitis (HP:0012384)2.63458705
47Type II lissencephaly (HP:0007260)2.58913006
48Aplasia/hypoplasia of the humerus (HP:0006507)2.57946834
49Rib fusion (HP:0000902)2.55363472
50Malnutrition (HP:0004395)2.54171780
51Short humerus (HP:0005792)2.51448721
52Plantar hyperkeratosis (HP:0007556)2.50736513
53Abnormality of the nasal septum (HP:0000419)2.47723331
54Decreased central vision (HP:0007663)2.46790598
55Abnormality of the salivary glands (HP:0010286)2.46735509
56Hypoplasia of the uterus (HP:0000013)2.46733715
57Aplasia/hypoplasia of the uterus (HP:0008684)2.44481467
58Interstitial pulmonary disease (HP:0006530)2.44188013
59Gastrointestinal atresia (HP:0002589)2.42510356
60Methylmalonic acidemia (HP:0002912)2.42036137
61Abnormal rod and cone electroretinograms (HP:0008323)2.40167416
62Cystic liver disease (HP:0006706)2.39884879
63Tongue fasciculations (HP:0001308)2.39279154
64Rectal fistula (HP:0100590)2.38811706
65Rectovaginal fistula (HP:0000143)2.38811706
66Abnormality of alanine metabolism (HP:0010916)2.35673739
67Hyperalaninemia (HP:0003348)2.35673739
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35673739
69Polydipsia (HP:0001959)2.35654227
70Abnormal drinking behavior (HP:0030082)2.35654227
71Male pseudohermaphroditism (HP:0000037)2.34780646
72* Woolly hair (HP:0002224)2.32695858
73Amelogenesis imperfecta (HP:0000705)2.31790210
74Absent rod-and cone-mediated responses on ERG (HP:0007688)2.30977660
75Aplasia/Hypoplasia of the spleen (HP:0010451)2.28613019
763-Methylglutaconic aciduria (HP:0003535)2.27908456
77Abnormality of the proximal phalanges of the hand (HP:0009834)2.26251791
78Intestinal atresia (HP:0011100)2.25534068
79Asplenia (HP:0001746)2.24846932
80Impulsivity (HP:0100710)2.24140244
81Furrowed tongue (HP:0000221)2.22764024
82Oral leukoplakia (HP:0002745)2.20735565
83Vaginal fistula (HP:0004320)2.20446643
84Methylmalonic aciduria (HP:0012120)2.20399724
85Fragile nails (HP:0001808)2.19343511
86Nail dystrophy (HP:0008404)2.19255558
87Alkalosis (HP:0001948)2.18938463
88Acute necrotizing encephalopathy (HP:0006965)2.18787173
89Abnormality of the middle phalanges of the toes (HP:0010183)2.16886707
90Milia (HP:0001056)2.16426101
91Medial flaring of the eyebrow (HP:0010747)2.16295046
92Abnormality of the preputium (HP:0100587)2.14696326
93Stenosis of the external auditory canal (HP:0000402)2.14003616
94Abnormality of the gastric mucosa (HP:0004295)2.13868133
95Palmar hyperkeratosis (HP:0010765)2.13628823
96Colon cancer (HP:0003003)2.12485959
97Chorioretinal atrophy (HP:0000533)2.11615331
98Abnormality of the anterior horn cell (HP:0006802)2.11301162
99Degeneration of anterior horn cells (HP:0002398)2.11301162
100Carpal bone hypoplasia (HP:0001498)2.11277540
101Bronchiectasis (HP:0002110)2.11066450
102Absent thumb (HP:0009777)2.10445426
103Abnormality of small intestinal villus morphology (HP:0011472)2.10366077
104Villous atrophy (HP:0011473)2.10366077
105Intestinal fistula (HP:0100819)2.10134015
106Distal lower limb muscle weakness (HP:0009053)2.09927969
107Mitochondrial inheritance (HP:0001427)2.09373266
108Birth length less than 3rd percentile (HP:0003561)2.08452754
109Sclerocornea (HP:0000647)2.08098273
110Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07507945
111Abnormality of cochlea (HP:0000375)2.06693599
112Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.06373312
113Goiter (HP:0000853)2.05979893
114Increased IgE level (HP:0003212)2.05846343
115Widely patent fontanelles and sutures (HP:0004492)2.05396536
116Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.05083336
117Vertebral hypoplasia (HP:0008417)2.05083336
118Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.05076197
119Dehydration (HP:0001944)2.04674818
120Duplicated collecting system (HP:0000081)2.03955634
121Muscle fibrillation (HP:0010546)2.03793972
122Chronic hepatic failure (HP:0100626)2.03442617
123Abnormality of renal excretion (HP:0011036)2.02828331
124Attenuation of retinal blood vessels (HP:0007843)2.02342070
125Renal cortical cysts (HP:0000803)2.02280501
126Selective tooth agenesis (HP:0001592)2.02161459
127Aplasia/Hypoplasia of the tibia (HP:0005772)2.01983977
128Hypohidrosis (HP:0000966)2.01960350
129Abdominal situs inversus (HP:0003363)2.01919931
130Abnormality of abdominal situs (HP:0011620)2.01919931
131Concave nail (HP:0001598)2.01555966
132Chronic bronchitis (HP:0004469)2.01224149
133Astrocytoma (HP:0009592)2.00988197
134Abnormality of the astrocytes (HP:0100707)2.00988197
135Long foot (HP:0001833)2.00912650
136Ileus (HP:0002595)2.00571035
137Cheilitis (HP:0100825)2.00005829
138Patellar aplasia (HP:0006443)1.99705067
139Abnormality of glutamine family amino acid metabolism (HP:0010902)1.99691965
140Alopecia of scalp (HP:0002293)1.98992924
141Large for gestational age (HP:0001520)1.98770777
142Symphalangism affecting the phalanges of the hand (HP:0009773)1.98621698
143Increased corneal curvature (HP:0100692)1.98377945
144Keratoconus (HP:0000563)1.98377945
145Gastrointestinal carcinoma (HP:0002672)1.97858311
146Malignant gastrointestinal tract tumors (HP:0006749)1.97858311
147Abnormality of vitamin B metabolism (HP:0004340)1.97342907
148Short hallux (HP:0010109)1.95992892
149Anal stenosis (HP:0002025)1.95824671
150Short femoral neck (HP:0100864)1.95313548
151Premature ovarian failure (HP:0008209)1.94596831
152Flat acetabular roof (HP:0003180)1.94483524
153Palmoplantar hyperkeratosis (HP:0000972)1.94467444
154Abnormality of chromosome stability (HP:0003220)1.94302344
155Abnormality of the ileum (HP:0001549)1.93426198
156Agitation (HP:0000713)1.92856115
157Abnormality of the vitamin B12 metabolism (HP:0004341)1.92527465
158Hypotrichosis (HP:0001006)1.91993232
159Trismus (HP:0000211)1.91785387
160Progressive macrocephaly (HP:0004481)1.91443667
161Increased CSF lactate (HP:0002490)1.90919030
162Genetic anticipation (HP:0003743)1.90904627
163Micronodular cirrhosis (HP:0001413)1.90811821
164Abnormal mitochondria in muscle tissue (HP:0008316)1.90504826
165Hyperaldosteronism (HP:0000859)1.90316851
166Polyuria (HP:0000103)1.90225653
167Abnormality of chloride homeostasis (HP:0011422)1.87032209
168Acute encephalopathy (HP:0006846)1.86558864
169Small intestinal stenosis (HP:0012848)1.86223890
170Duodenal stenosis (HP:0100867)1.86223890
171Uterine neoplasm (HP:0010784)1.85777103
172Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.85398025
173Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.85307969
174Abnormality of urine glucose concentration (HP:0011016)1.84883049
175Glycosuria (HP:0003076)1.84883049
176Fibular aplasia (HP:0002990)1.84692510
177Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.84233511
178Renal salt wasting (HP:0000127)1.84155958
179Aplasia/Hypoplasia of the hallux (HP:0008362)1.83881311
180Short tibia (HP:0005736)1.83710951
181Urethral obstruction (HP:0000796)1.83156769
182Confusion (HP:0001289)1.82940694
183Rhabdomyosarcoma (HP:0002859)1.82922136
184Abnormality of the renal collecting system (HP:0004742)1.82569521
185Neoplasm of the pancreas (HP:0002894)1.82399071
186Glioma (HP:0009733)1.82203631
187Aplasia/Hypoplasia of the patella (HP:0006498)1.82197357
188Hypomagnesemia (HP:0002917)1.81983798
189Progressive cerebellar ataxia (HP:0002073)1.81721319
190Meckel diverticulum (HP:0002245)1.81256152
191Ectopic kidney (HP:0000086)1.80484680
192Supernumerary spleens (HP:0009799)1.80272440
193Short 1st metacarpal (HP:0010034)1.78243458
194Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.78243458
195Hypothermia (HP:0002045)1.77815679
196Thyroid-stimulating hormone excess (HP:0002925)1.76979681
197Abnormality of the 1st metacarpal (HP:0010009)1.76516376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.19580374
2MST45.10900653
3AKT34.07325546
4TLK13.23168965
5ADRBK23.20239807
6MST1R2.98834480
7STK392.78304905
8RPS6KB22.71326792
9TTK2.58487806
10WNK42.48123369
11CDK122.32717286
12BMPR1B2.29422882
13OXSR12.28197269
14TAOK32.25331308
15STK38L1.96445108
16FRK1.88562155
17STK101.83300243
18BUB11.72727535
19MET1.70062491
20TSSK61.69027926
21MAPKAPK31.67189799
22NME11.65012012
23WEE11.64138505
24ZAK1.63488520
25PAK41.58612016
26INSRR1.57939295
27PDK21.54824356
28MAPK151.53351126
29FER1.51652360
30MAP2K21.48524013
31LATS11.45359246
32MAP4K21.44246380
33MAP3K31.43987134
34CDK71.43819356
35MATK1.41494820
36TXK1.39858272
37ADRBK11.33787798
38PRKCI1.31735654
39WNK31.29419461
40CASK1.28021456
41TESK11.27741090
42STK241.23228532
43PRKG21.21632364
44PHKG11.19984820
45PHKG21.19984820
46IRAK31.19200262
47YES11.18742348
48LMTK21.16745661
49TRPM71.15711447
50PLK11.14213268
51TGFBR21.11471494
52MAP3K81.10337806
53MAP3K121.10039098
54SRPK11.08506318
55MAP3K141.06303606
56AURKB1.06055148
57DDR21.05595246
58CHEK21.05444535
59STK31.04343617
60PIK3CA1.02147989
61TNIK1.02055255
62STK161.00196071
63PLK40.98917395
64DAPK20.98527107
65ACVR1B0.97942388
66PRKCE0.93725037
67NUAK10.90163467
68MAPK130.89877433
69ERBB30.89594869
70ATR0.89357928
71GRK10.88495241
72PRKCG0.87929262
73CSK0.86860900
74PAK30.84155321
75MAP3K40.82237020
76PIM10.82160035
77PLK30.82008962
78NEK10.80831649
79CAMKK20.80426604
80MAP3K20.79050470
81EPHB20.78649412
82PNCK0.77951174
83CDK60.77715129
84EIF2AK20.74883011
85BRD40.74489652
86MUSK0.72099321
87GRK70.72073014
88PIM20.71705297
89EIF2AK30.71146039
90DYRK20.71020818
91CHUK0.70922989
92PTK2B0.69836565
93AURKA0.69360642
94PRKCQ0.69071325
95EIF2AK10.68703329
96ERBB20.68160038
97VRK10.66300142
98EPHA30.63543564
99MYLK0.62637671
100ERBB40.62523952
101GRK50.60504521
102STK40.60396561
103TEC0.59598300
104NEK20.58051116
105MAPKAPK20.57221631
106PRKCA0.56881414
107PRKACA0.56317300
108MAP2K60.55815873
109CSNK1A10.55507644
110TIE10.54880514
111TRIM280.52898087
112CSNK1G20.50474589
113CDC70.49599738
114IGF1R0.49253587
115CHEK10.49163719
116CAMK2A0.49007804
117RIPK10.48730735
118BCR0.48663812
119RPS6KA50.48028471
120ABL20.47866877
121BRSK20.47790530
122ATM0.47787726
123ICK0.47632500
124PTK60.47498075
125CDK80.45709574
126NTRK30.45319718
127CSNK1G10.44492358
128MAP2K70.44490629
129GRK60.43647969
130ALK0.42941170
131MKNK10.42591174
132SGK20.42326737
133NLK0.41069498
134BCKDK0.40350852
135CSNK1G30.40172980
136BRAF0.39266150
137PLK20.39133910
138DYRK30.39081082
139IKBKB0.39073515
140TGFBR10.38731051
141CSNK2A10.38103749
142MAP3K110.37652845
143MKNK20.37631157
144MAP2K10.37059127
145MELK0.36552840
146SGK2230.36516180
147SGK4940.36516180
148GSK3A0.36355886
149PRKCZ0.35738277
150TAOK20.35173371
151PASK0.34994428
152KIT0.34903823
153RPS6KA40.34815493
154PRKCD0.34507070
155CDK90.33703053
156MAPKAPK50.32790528
157PRKACG0.32296293
158PRKD20.32050231
159RPS6KA60.30999525
160IRAK10.30352897
161CDK20.30341122
162PTK20.29814009
163STK110.29216591
164IKBKE0.28842745
165CDK40.27755702
166PAK10.27025303
167NEK90.26732119
168PINK10.26256930
169RPS6KA10.25872964

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.17980092
2DNA replication_Homo sapiens_hsa030302.98202951
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.86581360
4Mineral absorption_Homo sapiens_hsa049782.73339646
5Nitrogen metabolism_Homo sapiens_hsa009102.67542845
6Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.65462054
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.55028090
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.32160971
9Oxidative phosphorylation_Homo sapiens_hsa001902.21448323
10Base excision repair_Homo sapiens_hsa034102.16860546
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16469658
12Fat digestion and absorption_Homo sapiens_hsa049752.13799617
13Renin-angiotensin system_Homo sapiens_hsa046142.12922869
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.11564901
15Phototransduction_Homo sapiens_hsa047442.08560807
16RNA transport_Homo sapiens_hsa030131.98570375
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97252000
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.96245300
19Retinol metabolism_Homo sapiens_hsa008301.91357019
20Homologous recombination_Homo sapiens_hsa034401.86988900
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.83659848
22Arachidonic acid metabolism_Homo sapiens_hsa005901.82416384
23Tryptophan metabolism_Homo sapiens_hsa003801.80529623
24Folate biosynthesis_Homo sapiens_hsa007901.69696602
25One carbon pool by folate_Homo sapiens_hsa006701.67019730
26Adherens junction_Homo sapiens_hsa045201.64722803
27Proteasome_Homo sapiens_hsa030501.63717539
28Nucleotide excision repair_Homo sapiens_hsa034201.63515117
29Fanconi anemia pathway_Homo sapiens_hsa034601.63307540
30RNA polymerase_Homo sapiens_hsa030201.63020179
31Galactose metabolism_Homo sapiens_hsa000521.62363871
32Fructose and mannose metabolism_Homo sapiens_hsa000511.58553220
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57374017
34p53 signaling pathway_Homo sapiens_hsa041151.56803314
35Cell cycle_Homo sapiens_hsa041101.55011384
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54573273
37Spliceosome_Homo sapiens_hsa030401.53548578
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.50706985
39Parkinsons disease_Homo sapiens_hsa050121.48185392
40Tight junction_Homo sapiens_hsa045301.47701526
41Linoleic acid metabolism_Homo sapiens_hsa005911.47075757
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44760258
43Vitamin digestion and absorption_Homo sapiens_hsa049771.42750093
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38286012
45Glutathione metabolism_Homo sapiens_hsa004801.34827247
46Hippo signaling pathway_Homo sapiens_hsa043901.28957932
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27473761
48Nicotine addiction_Homo sapiens_hsa050331.25548444
49Ribosome_Homo sapiens_hsa030101.25061161
50Glycerolipid metabolism_Homo sapiens_hsa005611.23573098
51Legionellosis_Homo sapiens_hsa051341.22904746
52Thyroid cancer_Homo sapiens_hsa052161.22795103
53Other glycan degradation_Homo sapiens_hsa005111.21220898
54Protein export_Homo sapiens_hsa030601.20593476
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17107729
56Basal transcription factors_Homo sapiens_hsa030221.16736656
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15671824
58Fatty acid biosynthesis_Homo sapiens_hsa000611.14991886
59Butanoate metabolism_Homo sapiens_hsa006501.13950676
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13839154
61Pyrimidine metabolism_Homo sapiens_hsa002401.12869693
62Alzheimers disease_Homo sapiens_hsa050101.11654875
63Non-homologous end-joining_Homo sapiens_hsa034501.10811700
64Huntingtons disease_Homo sapiens_hsa050161.10343858
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07369721
66Sphingolipid metabolism_Homo sapiens_hsa006001.04981103
67Cyanoamino acid metabolism_Homo sapiens_hsa004601.03889861
68Sulfur metabolism_Homo sapiens_hsa009201.02179409
69Cardiac muscle contraction_Homo sapiens_hsa042601.01287421
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99760385
71Pancreatic secretion_Homo sapiens_hsa049720.99174678
72TGF-beta signaling pathway_Homo sapiens_hsa043500.98719488
73Bladder cancer_Homo sapiens_hsa052190.96885604
74Asthma_Homo sapiens_hsa053100.95803390
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.95302749
76Collecting duct acid secretion_Homo sapiens_hsa049660.93034388
77Peroxisome_Homo sapiens_hsa041460.92154415
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90448119
79Taste transduction_Homo sapiens_hsa047420.87693698
80Antigen processing and presentation_Homo sapiens_hsa046120.87366297
81Starch and sucrose metabolism_Homo sapiens_hsa005000.86994583
82Insulin secretion_Homo sapiens_hsa049110.82930060
83Herpes simplex infection_Homo sapiens_hsa051680.81484485
84Ether lipid metabolism_Homo sapiens_hsa005650.81038009
85Type I diabetes mellitus_Homo sapiens_hsa049400.79644241
86Serotonergic synapse_Homo sapiens_hsa047260.79165022
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78765707
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76885643
89Influenza A_Homo sapiens_hsa051640.76377707
90mRNA surveillance pathway_Homo sapiens_hsa030150.76359700
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.76268272
92Protein digestion and absorption_Homo sapiens_hsa049740.76142255
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.75796382
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75287105
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75111254
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74959646
97beta-Alanine metabolism_Homo sapiens_hsa004100.73441423
98Olfactory transduction_Homo sapiens_hsa047400.72035085
99Histidine metabolism_Homo sapiens_hsa003400.71904804
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71604913
101ABC transporters_Homo sapiens_hsa020100.71224295
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70945260
103Selenocompound metabolism_Homo sapiens_hsa004500.70920452
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70100424
105Notch signaling pathway_Homo sapiens_hsa043300.68402840
106Small cell lung cancer_Homo sapiens_hsa052220.67801853
107Bile secretion_Homo sapiens_hsa049760.67731839
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67112100
109Ovarian steroidogenesis_Homo sapiens_hsa049130.66365476
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66118359
111Graft-versus-host disease_Homo sapiens_hsa053320.65855350
112Caffeine metabolism_Homo sapiens_hsa002320.65626548
113Epstein-Barr virus infection_Homo sapiens_hsa051690.65405816
114Apoptosis_Homo sapiens_hsa042100.65352734
115Fatty acid degradation_Homo sapiens_hsa000710.65271838
116Viral carcinogenesis_Homo sapiens_hsa052030.64665462
117Hepatitis C_Homo sapiens_hsa051600.63821724
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63601956
119Morphine addiction_Homo sapiens_hsa050320.63178621
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63104852
121Autoimmune thyroid disease_Homo sapiens_hsa053200.62759864
122Purine metabolism_Homo sapiens_hsa002300.60978186
123Allograft rejection_Homo sapiens_hsa053300.60815479
124RNA degradation_Homo sapiens_hsa030180.59047211
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58860343
126Metabolic pathways_Homo sapiens_hsa011000.56764660
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55318293
128Arginine and proline metabolism_Homo sapiens_hsa003300.54522587
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.54090979
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53997027
131MicroRNAs in cancer_Homo sapiens_hsa052060.53207275
132Tyrosine metabolism_Homo sapiens_hsa003500.52997198
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.52641437
134Basal cell carcinoma_Homo sapiens_hsa052170.51634860
135Sulfur relay system_Homo sapiens_hsa041220.50197393
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49318796
137Shigellosis_Homo sapiens_hsa051310.48562768
138Salivary secretion_Homo sapiens_hsa049700.48262859
139NF-kappa B signaling pathway_Homo sapiens_hsa040640.47662658
140Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44344678
141Regulation of autophagy_Homo sapiens_hsa041400.43715661
142PPAR signaling pathway_Homo sapiens_hsa033200.39753471
143Steroid biosynthesis_Homo sapiens_hsa001000.39474861
144Pathways in cancer_Homo sapiens_hsa052000.38625119
145Endometrial cancer_Homo sapiens_hsa052130.38588086
146Lysosome_Homo sapiens_hsa041420.36266004
147Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36237812
148Prostate cancer_Homo sapiens_hsa052150.35707754
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35306897
150Toxoplasmosis_Homo sapiens_hsa051450.34989417
151Rheumatoid arthritis_Homo sapiens_hsa053230.34265429
152Propanoate metabolism_Homo sapiens_hsa006400.34066379
153Primary immunodeficiency_Homo sapiens_hsa053400.34017989
154SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34000894
155Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33431139
156Circadian entrainment_Homo sapiens_hsa047130.33191807
157Dorso-ventral axis formation_Homo sapiens_hsa043200.32945051
158Hematopoietic cell lineage_Homo sapiens_hsa046400.32511072
159Salmonella infection_Homo sapiens_hsa051320.31334180
160Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31074108
161Colorectal cancer_Homo sapiens_hsa052100.30403160
162Glutamatergic synapse_Homo sapiens_hsa047240.30175993
163HTLV-I infection_Homo sapiens_hsa051660.29398571
164Pertussis_Homo sapiens_hsa051330.29366161
165Glycosaminoglycan degradation_Homo sapiens_hsa005310.28069231
166Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27268670
167Chemical carcinogenesis_Homo sapiens_hsa052040.25202776

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »