LIPI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic acid. Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia. This gene is also expressed at high levels in Ewing family tumor cells. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1seminiferous tubule development (GO:0072520)9.89306904
2sperm capacitation (GO:0048240)9.77968817
3adrenergic receptor signaling pathway (GO:0071875)9.67973554
4response to phenylpropanoid (GO:0080184)8.95819600
5peripheral nervous system neuron development (GO:0048935)6.61988888
6production of molecular mediator involved in inflammatory response (GO:0002532)6.53002488
7adult feeding behavior (GO:0008343)5.65068344
8facial nerve structural organization (GO:0021612)5.50765717
9proximal/distal pattern formation (GO:0009954)5.40335833
10regulation of T cell tolerance induction (GO:0002664)5.39360795
11single fertilization (GO:0007338)5.20798347
12negative regulation of heart contraction (GO:0045822)5.20546822
13kynurenine metabolic process (GO:0070189)5.12064243
14cranial nerve structural organization (GO:0021604)4.95729094
15vitamin transmembrane transport (GO:0035461)4.93244814
16regulation of phospholipase A2 activity (GO:0032429)4.89067221
17muscle organ morphogenesis (GO:0048644)4.72647247
18sleep (GO:0030431)4.67607187
19dorsal/ventral neural tube patterning (GO:0021904)4.62404363
20positive regulation of tolerance induction (GO:0002645)4.38075553
21indole-containing compound catabolic process (GO:0042436)4.35728691
22indolalkylamine catabolic process (GO:0046218)4.35728691
23tryptophan catabolic process (GO:0006569)4.35728691
24cellular response to prostaglandin stimulus (GO:0071379)4.30385571
25adenosine metabolic process (GO:0046085)4.24866951
26superoxide anion generation (GO:0042554)4.23474659
27respiratory burst (GO:0045730)4.13961755
28heterotypic cell-cell adhesion (GO:0034113)4.10913172
29negative regulation of blood circulation (GO:1903523)4.04594263
30regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.99452230
31forelimb morphogenesis (GO:0035136)3.96602409
32regulation of tolerance induction (GO:0002643)3.95032159
33hindlimb morphogenesis (GO:0035137)3.83372751
34negative regulation of JAK-STAT cascade (GO:0046426)3.79977538
35substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.76989914
36substrate-independent telencephalic tangential migration (GO:0021826)3.76989914
37kinetochore organization (GO:0051383)3.74805645
38vasoconstriction (GO:0042310)3.71694362
39cell migration in hindbrain (GO:0021535)3.68658575
40tryptophan metabolic process (GO:0006568)3.67479086
41regulation of short-term neuronal synaptic plasticity (GO:0048172)3.65571684
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.63747249
43neuronal action potential propagation (GO:0019227)3.63488442
44cellular response to estrogen stimulus (GO:0071391)3.63147309
45prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.63082123
46multicellular organism reproduction (GO:0032504)3.58834967
47calcium ion import (GO:0070509)3.56620701
48regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.51498071
49phagocytosis, recognition (GO:0006910)3.49761491
50negative regulation of multicellular organism growth (GO:0040015)3.47687108
51pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.46917193
52embryonic forelimb morphogenesis (GO:0035115)3.43590918
53negative regulation of cytosolic calcium ion concentration (GO:0051481)3.39894163
54regulation of chronic inflammatory response (GO:0002676)3.38332565
55fertilization (GO:0009566)3.37703991
56trophoblast giant cell differentiation (GO:0060707)3.36935963
57male sex determination (GO:0030238)3.36246529
58Leydig cell differentiation (GO:0033327)3.35017429
59CENP-A containing nucleosome assembly (GO:0034080)3.34239921
60chromatin remodeling at centromere (GO:0031055)3.33989596
61negative regulation of glial cell differentiation (GO:0045686)3.33326938
62mitotic sister chromatid cohesion (GO:0007064)3.32946649
63early endosome to late endosome transport (GO:0045022)3.32480576
64anatomical structure arrangement (GO:0048532)3.30076518
65neurotransmitter-gated ion channel clustering (GO:0072578)3.28787496
66regulation of DNA endoreduplication (GO:0032875)3.25363824
67kinetochore assembly (GO:0051382)3.24051465
68cellular response to pH (GO:0071467)3.21422018
69amine catabolic process (GO:0009310)3.20643815
70cellular biogenic amine catabolic process (GO:0042402)3.20643815
71L-serine metabolic process (GO:0006563)3.20331686
72response to pH (GO:0009268)3.16413003
73cranial nerve morphogenesis (GO:0021602)3.15981489
74negative regulation of astrocyte differentiation (GO:0048712)3.15711084
75short-term memory (GO:0007614)3.13471002
76thyroid gland development (GO:0030878)3.13168788
77regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.12705639
78folic acid transport (GO:0015884)3.11074837
79embryonic digit morphogenesis (GO:0042733)3.10901735
80pyrimidine nucleotide catabolic process (GO:0006244)3.10863244
81regulation of feeding behavior (GO:0060259)3.08685383
82DNA replication-dependent nucleosome organization (GO:0034723)3.08626116
83DNA replication-dependent nucleosome assembly (GO:0006335)3.08626116
84negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.08571544
85arachidonic acid secretion (GO:0050482)3.08024067
86icosanoid secretion (GO:0032309)3.08024067
87negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05439582
88positive regulation of type 2 immune response (GO:0002830)3.05051191
89neuron remodeling (GO:0016322)3.04933444
90regulation of mRNA splicing, via spliceosome (GO:0048024)3.03783448
91epithelial cell morphogenesis (GO:0003382)3.03383096
92positive regulation of response to oxidative stress (GO:1902884)3.02654739
93positive regulation of cellular response to oxidative stress (GO:1900409)3.02654739
94cerebral cortex radially oriented cell migration (GO:0021799)3.01390754
95aromatic amino acid family catabolic process (GO:0009074)3.01364133
96dorsal/ventral axis specification (GO:0009950)3.01359748
97cardiac left ventricle morphogenesis (GO:0003214)2.99938366
98membrane depolarization during action potential (GO:0086010)2.99861397
99negative regulation of interleukin-10 production (GO:0032693)2.99471264
100positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.98147457
101cellular response to ketone (GO:1901655)2.93874381
102outer ear morphogenesis (GO:0042473)2.93655846
103positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.93423326
104negative regulation of systemic arterial blood pressure (GO:0003085)2.92014576
105DNA replication checkpoint (GO:0000076)2.90233018
106negative regulation of DNA-dependent DNA replication (GO:2000104)2.89662213
107base-excision repair, AP site formation (GO:0006285)2.89396259
108dosage compensation (GO:0007549)2.88978459
109paraxial mesoderm development (GO:0048339)2.88637159
110reproduction (GO:0000003)2.88466430
111negative regulation of cardiac muscle hypertrophy (GO:0010614)2.88269905
112negative regulation of oligodendrocyte differentiation (GO:0048715)2.87590370
113fucose catabolic process (GO:0019317)2.86418752
114L-fucose metabolic process (GO:0042354)2.86418752
115L-fucose catabolic process (GO:0042355)2.86418752
116mammary gland development (GO:0030879)2.85961513
117sister chromatid segregation (GO:0000819)2.85685635
118DNA replication-independent nucleosome organization (GO:0034724)2.84354538
119DNA replication-independent nucleosome assembly (GO:0006336)2.84354538
120DNA topological change (GO:0006265)2.83974612
121negative regulation of erythrocyte differentiation (GO:0045647)2.82860155
122DNA double-strand break processing (GO:0000729)2.81975008
123tolerance induction (GO:0002507)2.81799179
124regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.81207783
125anterior/posterior axis specification, embryo (GO:0008595)2.80794211
126positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.78838700
127regulation of interleukin-8 secretion (GO:2000482)2.78825310
128regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.76277263
129opioid receptor signaling pathway (GO:0038003)2.76132078
130histone exchange (GO:0043486)2.74879311
131embryonic skeletal system morphogenesis (GO:0048704)2.73960008
132indolalkylamine metabolic process (GO:0006586)2.72657136
133adaptation of signaling pathway (GO:0023058)2.72639084
134regulation of inositol phosphate biosynthetic process (GO:0010919)2.71278381
135pyrimidine-containing compound transmembrane transport (GO:0072531)2.70079066
136regulation of centriole replication (GO:0046599)2.69426363
137fatty acid elongation (GO:0030497)2.68645010
138icosanoid transport (GO:0071715)2.67692354
139fatty acid derivative transport (GO:1901571)2.67692354
140regulation of synapse assembly (GO:0051963)2.67636055
141ventricular system development (GO:0021591)2.66864395
142microtubule depolymerization (GO:0007019)2.66471505
143negative regulation of synaptic transmission, GABAergic (GO:0032229)2.65996023
144positive regulation of synapse assembly (GO:0051965)2.64196930
145positive regulation of interleukin-8 secretion (GO:2000484)2.63805422
146mitotic sister chromatid segregation (GO:0000070)2.62448808
147positive regulation of dendritic spine morphogenesis (GO:0061003)2.62367531
148mitotic G1 DNA damage checkpoint (GO:0031571)2.61512633
149metaphase plate congression (GO:0051310)2.60522870
150glucuronate metabolic process (GO:0019585)2.60367824
151uronic acid metabolic process (GO:0006063)2.60367824
152positive regulation of protein kinase C signaling (GO:0090037)2.60136383
153potassium ion export (GO:0071435)2.59770013
154negative regulation of protein autophosphorylation (GO:0031953)2.58916855
155forebrain neuron development (GO:0021884)2.57768633
156keratinocyte proliferation (GO:0043616)2.57127016
157transepithelial transport (GO:0070633)2.56664661
158protein localization to kinetochore (GO:0034501)2.55820847
159mitotic metaphase plate congression (GO:0007080)2.54872074
160T cell migration (GO:0072678)2.54625288
161replication fork processing (GO:0031297)2.54602479
162regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.53961586
163regulation of platelet aggregation (GO:0090330)2.53478984
164protein localization to chromosome, centromeric region (GO:0071459)2.53092530
165positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.52987581
166negative regulation of muscle hypertrophy (GO:0014741)2.52818780
167mitotic G2/M transition checkpoint (GO:0044818)2.52110494
168regulation of glutamate receptor signaling pathway (GO:1900449)2.52029539
169meiotic chromosome segregation (GO:0045132)2.51404101
170negative regulation of gliogenesis (GO:0014014)2.51106982
171skeletal system morphogenesis (GO:0048705)2.51099920
172ATP-dependent chromatin remodeling (GO:0043044)2.51089596
173positive regulation of fibroblast migration (GO:0010763)2.50667701
174pyrimidine dimer repair (GO:0006290)2.49482024
175positive regulation of cell-cell adhesion (GO:0022409)2.49012142
176mitotic chromosome condensation (GO:0007076)2.46475911
177dorsal/ventral pattern formation (GO:0009953)2.45566455
178negative regulation of interleukin-8 production (GO:0032717)2.45564576
179regulation of nuclear cell cycle DNA replication (GO:0033262)2.44235253
180mitotic DNA integrity checkpoint (GO:0044774)2.43809625
181positive regulation of natural killer cell differentiation (GO:0032825)2.42880741
182presynaptic membrane assembly (GO:0097105)2.42819170
183axis elongation (GO:0003401)2.42265492
184response to folic acid (GO:0051593)2.41383012
185response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.40836616
186negative regulation of lipase activity (GO:0060192)2.40454275
187sperm motility (GO:0030317)2.40090092
188regulation of male gonad development (GO:2000018)2.39280199
189chondrocyte proliferation (GO:0035988)2.38599035
190protein-DNA complex disassembly (GO:0032986)2.38055977
191nucleosome disassembly (GO:0006337)2.38055977
192positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.37550356
193positive regulation of cell cycle G2/M phase transition (GO:1902751)2.37550356
194branch elongation of an epithelium (GO:0060602)2.37102610
195G1 DNA damage checkpoint (GO:0044783)2.34230014
196protein localization to chromosome (GO:0034502)2.33717021
197bone morphogenesis (GO:0060349)2.29831256
198calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.29561522
199positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.28836539

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.06254403
2E2F7_22180533_ChIP-Seq_HELA_Human4.58695758
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.75634742
4EZH2_22144423_ChIP-Seq_EOC_Human3.47483528
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.20118883
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.94933357
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91226468
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.63232948
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45992103
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45082481
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43846074
12IKZF1_21737484_ChIP-ChIP_HCT116_Human2.42634946
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41827958
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40126927
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40126927
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34307664
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.32900545
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29211974
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27305338
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23359877
21AR_21572438_ChIP-Seq_LNCaP_Human2.22706797
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.15351396
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.12157280
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.06212945
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.04527235
26JARID2_20075857_ChIP-Seq_MESCs_Mouse2.01374995
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96325774
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92650332
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.88155550
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85571588
31TAF15_26573619_Chip-Seq_HEK293_Human1.82593984
32ZNF274_21170338_ChIP-Seq_K562_Hela1.81842017
33GBX2_23144817_ChIP-Seq_PC3_Human1.81058682
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81036768
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80560445
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79142304
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.76780668
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.76046819
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.72649106
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72456306
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70794369
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68227497
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.66431722
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.63155141
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63119300
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61241937
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60951929
48FUS_26573619_Chip-Seq_HEK293_Human1.60167827
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.58879177
50ELK1_19687146_ChIP-ChIP_HELA_Human1.57360182
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57290707
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.56374660
53DROSHA_22980978_ChIP-Seq_HELA_Human1.53727747
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51548748
55SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.50310457
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.48718917
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.45963463
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45815280
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44869796
60KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44869796
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44869796
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.41028481
63FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40624089
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37927102
65IGF1R_20145208_ChIP-Seq_DFB_Human1.36608053
66EWS_26573619_Chip-Seq_HEK293_Human1.35096556
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.31585947
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30878534
69SOX9_26525672_Chip-Seq_HEART_Mouse1.30606022
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29436508
71IRF8_21731497_ChIP-ChIP_J774_Mouse1.29040392
72MYC_18555785_ChIP-Seq_MESCs_Mouse1.26132917
73* P300_19829295_ChIP-Seq_ESCs_Human1.21959901
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20292814
75HTT_18923047_ChIP-ChIP_STHdh_Human1.19881860
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19210812
77TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18206341
78TCF4_18268006_ChIP-ChIP_LS174T_Human1.17514419
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17478930
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17355582
81* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17172223
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16993268
83ESRRB_18555785_Chip-Seq_ESCs_Mouse1.16772329
84RNF2_27304074_Chip-Seq_NSC_Mouse1.16381721
85EGR1_19032775_ChIP-ChIP_M12_Human1.16342223
86SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15441876
87SOX2_16153702_ChIP-ChIP_HESCs_Human1.15390925
88SMAD1_18555785_Chip-Seq_ESCs_Mouse1.14496071
89TP53_18474530_ChIP-ChIP_U2OS_Human1.14392999
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.14118474
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13017827
92POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12605721
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12343992
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11649444
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11278823
96MYC_18940864_ChIP-ChIP_HL60_Human1.11178583
97LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10759248
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09877745
99SOX2_18555785_Chip-Seq_ESCs_Mouse1.09026759
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08598153
101GABP_17652178_ChIP-ChIP_JURKAT_Human1.08240708
102RUNX1_27457419_Chip-Seq_LIVER_Mouse1.07245830
103* SMAD3_21741376_ChIP-Seq_HESCs_Human1.05748090
104BCAT_22108803_ChIP-Seq_LS180_Human1.05634565
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04809813
106WT1_19549856_ChIP-ChIP_CCG9911_Human1.04308630
107POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03803105
108KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03033646
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02602009
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01912725
111OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01691281
112PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01440189
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01174210
114CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00101644
115CTCF_18555785_Chip-Seq_ESCs_Mouse1.00054264
116SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99936014
117CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99773142
118* REST_21632747_ChIP-Seq_MESCs_Mouse0.99694844
119TP53_16413492_ChIP-PET_HCT116_Human0.99213248
120THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98866011
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.98479728
122GATA3_21867929_ChIP-Seq_TH1_Mouse0.98358339
123SMAD4_21799915_ChIP-Seq_A2780_Human0.98023857
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97964404
125PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97459704
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96729443
127RING1B_27294783_Chip-Seq_NPCs_Mouse0.96684396
128MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96450526
129P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96275935
130* TAL1_26923725_Chip-Seq_HPCs_Mouse0.95940107
131E2F1_18555785_Chip-Seq_ESCs_Mouse0.95870582
132RING1B_27294783_Chip-Seq_ESCs_Mouse0.95430303
133PIAS1_25552417_ChIP-Seq_VCAP_Human0.95154079
134VDR_22108803_ChIP-Seq_LS180_Human0.94492545
135SMAD3_21741376_ChIP-Seq_EPCs_Human0.94130048
136TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94080264
137KLF4_18555785_Chip-Seq_ESCs_Mouse0.92906078
138VDR_24787735_ChIP-Seq_THP-1_Human0.92795844
139P300_18555785_Chip-Seq_ESCs_Mouse0.92231309
140TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92191077
141NANOG_16153702_ChIP-ChIP_HESCs_Human0.91924074
142REST_18959480_ChIP-ChIP_MESCs_Mouse0.91892544
143KDM2B_26808549_Chip-Seq_REH_Human0.91889264
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91743656
145STAT3_18555785_Chip-Seq_ESCs_Mouse0.90804196
146CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90778045
147CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90523079
148TP53_20018659_ChIP-ChIP_R1E_Mouse0.90517516
149TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90481444
150CMYC_18555785_Chip-Seq_ESCs_Mouse0.90286109
151CRX_20693478_ChIP-Seq_RETINA_Mouse0.88829860
152TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88564422
153POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88564422
154MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88448207
155MYC_19079543_ChIP-ChIP_MESCs_Mouse0.88051037
156P53_22387025_ChIP-Seq_ESCs_Mouse0.87760429
157THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87188749

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo6.50142182
2MP0003303_peritoneal_inflammation4.08588026
3MP0008260_abnormal_autophagy3.69347137
4MP0005451_abnormal_body_composition3.47278667
5MP0003941_abnormal_skin_development3.04322950
6MP0005503_abnormal_tendon_morphology3.01043472
7MP0005409_darkened_coat_color3.00416597
8MP0004142_abnormal_muscle_tone2.95970751
9MP0003136_yellow_coat_color2.78358517
10MP0004381_abnormal_hair_follicle2.57639047
11MP0009053_abnormal_anal_canal2.52574402
12MP0002254_reproductive_system_inflammat2.48615678
13MP0003890_abnormal_embryonic-extraembry2.36548787
14MP0002932_abnormal_joint_morphology2.27111984
15MP0005058_abnormal_lysosome_morphology2.24130085
16MP0005394_taste/olfaction_phenotype2.19746760
17MP0005499_abnormal_olfactory_system2.19746760
18MP0003880_abnormal_central_pattern2.19269731
19MP0009250_abnormal_appendicular_skeleto2.09533600
20MP0000049_abnormal_middle_ear2.03754613
21MP0000537_abnormal_urethra_morphology1.99436726
22MP0002735_abnormal_chemical_nociception1.96455449
23MP0003959_abnormal_lean_body1.95841696
24MP0005174_abnormal_tail_pigmentation1.95413926
25MP0005187_abnormal_penis_morphology1.91897014
26MP0001286_abnormal_eye_development1.91887589
27MP0003950_abnormal_plasma_membrane1.88586301
28MP0001486_abnormal_startle_reflex1.86847529
29MP0005377_hearing/vestibular/ear_phenot1.85321090
30MP0003878_abnormal_ear_physiology1.85321090
31MP0001905_abnormal_dopamine_level1.81013238
32MP0001968_abnormal_touch/_nociception1.80453041
33MP0010094_abnormal_chromosome_stability1.80163016
34MP0003635_abnormal_synaptic_transmissio1.79276814
35MP0004885_abnormal_endolymph1.77235832
36MP0005623_abnormal_meninges_morphology1.74540262
37MP0008872_abnormal_physiological_respon1.72670681
38MP0003111_abnormal_nucleus_morphology1.72554526
39MP0009046_muscle_twitch1.71102362
40MP0003937_abnormal_limbs/digits/tail_de1.69466803
41MP0004859_abnormal_synaptic_plasticity1.69367186
42MP0002102_abnormal_ear_morphology1.69296911
43MP0009745_abnormal_behavioral_response1.69147418
44MP0002163_abnormal_gland_morphology1.66078595
45MP0004019_abnormal_vitamin_homeostasis1.62412603
46MP0002971_abnormal_brown_adipose1.57477401
47MP0001293_anophthalmia1.56084272
48MP0003938_abnormal_ear_development1.55725759
49MP0002653_abnormal_ependyma_morphology1.55205521
50MP0002089_abnormal_postnatal_growth/wei1.55076861
51MP0003195_calcinosis1.49404436
52MP0001440_abnormal_grooming_behavior1.49333228
53MP0002233_abnormal_nose_morphology1.48678878
54MP0002796_impaired_skin_barrier1.48292679
55MP0001188_hyperpigmentation1.45436775
56MP0009379_abnormal_foot_pigmentation1.44331427
57MP0003755_abnormal_palate_morphology1.41484645
58MP0003879_abnormal_hair_cell1.41349157
59MP0001661_extended_life_span1.40797663
60MP0004742_abnormal_vestibular_system1.40292623
61MP0002111_abnormal_tail_morphology1.33854122
62MP0010386_abnormal_urinary_bladder1.33127825
63MP0002998_abnormal_bone_remodeling1.32299464
64MP0009384_cardiac_valve_regurgitation1.31850243
65MP0002116_abnormal_craniofacial_bone1.30666313
66MP0005076_abnormal_cell_differentiation1.30419179
67MP0002896_abnormal_bone_mineralization1.29788920
68MP0006292_abnormal_olfactory_placode1.29359257
69MP0003718_maternal_effect1.27757351
70MP0000566_synostosis1.27541526
71MP0004957_abnormal_blastocyst_morpholog1.26513043
72MP0000428_abnormal_craniofacial_morphol1.26334480
73MP0005360_urolithiasis1.25578452
74MP0002272_abnormal_nervous_system1.24837343
75MP0002064_seizures1.23304872
76MP0002557_abnormal_social/conspecific_i1.23187077
77MP0008932_abnormal_embryonic_tissue1.20896276
78MP0003011_delayed_dark_adaptation1.20616346
79MP0000613_abnormal_salivary_gland1.20321001
80MP0002109_abnormal_limb_morphology1.19504478
81MP0000383_abnormal_hair_follicle1.19093769
82MP0003077_abnormal_cell_cycle1.17121113
83MP0003119_abnormal_digestive_system1.15522676
84MP0003861_abnormal_nervous_system1.15228428
85MP0003690_abnormal_glial_cell1.13055931
86MP0001664_abnormal_digestion1.12797201
87MP0002067_abnormal_sensory_capabilities1.12558782
88MP0003693_abnormal_embryo_hatching1.10205194
89MP0002234_abnormal_pharynx_morphology1.09950020
90MP0005334_abnormal_fat_pad1.08474460
91MP0005551_abnormal_eye_electrophysiolog1.07559844
92MP0002751_abnormal_autonomic_nervous1.06787585
93MP0001663_abnormal_digestive_system1.06200208
94MP0000647_abnormal_sebaceous_gland1.05703711
95MP0004270_analgesia1.05565720
96MP0008438_abnormal_cutaneous_collagen1.02815717
97MP0003172_abnormal_lysosome_physiology1.02271685
98MP0002115_abnormal_skeleton_extremities1.01504724
99MP0005410_abnormal_fertilization1.01088011
100MP0001765_abnormal_ion_homeostasis1.00374892
101MP0003935_abnormal_craniofacial_develop1.00038884
102MP0000026_abnormal_inner_ear0.99823387
103MP0000163_abnormal_cartilage_morphology0.99817349
104MP0001873_stomach_inflammation0.99619619
105MP0001501_abnormal_sleep_pattern0.99438074
106MP0005379_endocrine/exocrine_gland_phen0.99377062
107MP0002419_abnormal_innate_immunity0.99152736
108MP0004197_abnormal_fetal_growth/weight/0.98127174
109MP0002277_abnormal_respiratory_mucosa0.97904569
110MP0002108_abnormal_muscle_morphology0.96471098
111MP0002084_abnormal_developmental_patter0.96002422
112MP0005381_digestive/alimentary_phenotyp0.95529186
113MP0002114_abnormal_axial_skeleton0.95189031
114MP0002085_abnormal_embryonic_tissue0.94749841
115MP0000920_abnormal_myelination0.94383521
116MP0005448_abnormal_energy_balance0.94219776
117MP0001727_abnormal_embryo_implantation0.93397104
118MP0008874_decreased_physiological_sensi0.91985292
119MP0002148_abnormal_hypersensitivity_rea0.90834608
120MP0002882_abnormal_neuron_morphology0.89571887
121MP0004510_myositis0.89341512
122MP0008058_abnormal_DNA_repair0.89135802
123MP0002160_abnormal_reproductive_system0.88814777
124MP0002006_tumorigenesis0.87857167
125MP0008877_abnormal_DNA_methylation0.87838573
126MP0000432_abnormal_head_morphology0.87474199
127MP0005395_other_phenotype0.87090988
128MP0000762_abnormal_tongue_morphology0.86707642
129MP0004185_abnormal_adipocyte_glucose0.85290033
130MP0005275_abnormal_skin_tensile0.85254865
131MP0000778_abnormal_nervous_system0.83809150
132MP0003315_abnormal_perineum_morphology0.83342311
133MP0001502_abnormal_circadian_rhythm0.83237182
134MP0002638_abnormal_pupillary_reflex0.82903324
135MP0000534_abnormal_ureter_morphology0.82371632
136MP0000955_abnormal_spinal_cord0.82252641
137MP0001963_abnormal_hearing_physiology0.82005909
138MP0005253_abnormal_eye_physiology0.81612340
139MP0001984_abnormal_olfaction0.81606173
140MP0003121_genomic_imprinting0.81551928
141MP0005508_abnormal_skeleton_morphology0.81534892
142MP0003942_abnormal_urinary_system0.80505427
143MP0009697_abnormal_copulation0.80306015
144MP0003698_abnormal_male_reproductive0.80120748
145MP0002184_abnormal_innervation0.79392588
146MP0001485_abnormal_pinna_reflex0.79333784
147MP0006082_CNS_inflammation0.79082031
148MP0005380_embryogenesis_phenotype0.77823912
149MP0001672_abnormal_embryogenesis/_devel0.77823912
150MP0003122_maternal_imprinting0.77769996
151MP0003638_abnormal_response/metabolism_0.77578674
152MP0002572_abnormal_emotion/affect_behav0.77450213
153MP0008961_abnormal_basal_metabolism0.77104743
154MP0001177_atelectasis0.76561851
155MP0005375_adipose_tissue_phenotype0.75923117
156MP0000003_abnormal_adipose_tissue0.75377045
157MP0004145_abnormal_muscle_electrophysio0.75028860
158MP0000750_abnormal_muscle_regeneration0.74364207
159MP0000350_abnormal_cell_proliferation0.74190258
160MP0001970_abnormal_pain_threshold0.73556785
161MP0008770_decreased_survivor_rate0.73058343
162MP0002752_abnormal_somatic_nervous0.72288070
163MP0003634_abnormal_glial_cell0.70959036
164MP0002063_abnormal_learning/memory/cond0.70320524
165MP0003385_abnormal_body_wall0.69591863
166MP0005387_immune_system_phenotype0.67733446
167MP0001790_abnormal_immune_system0.67733446
168MP0000427_abnormal_hair_cycle0.66948865
169MP0005595_abnormal_vascular_smooth0.66484799
170MP0005452_abnormal_adipose_tissue0.66363759
171MP0003705_abnormal_hypodermis_morpholog0.65647646

Predicted human phenotypes

RankGene SetZ-score
1Osteomalacia (HP:0002749)8.07330622
2Hypophosphatemic rickets (HP:0004912)7.77846069
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.50945195
4Upper limb muscle weakness (HP:0003484)5.50415495
5Spinal cord compression (HP:0002176)5.33158765
6Abnormality of calcium-phosphate metabolism (HP:0100530)5.09009251
7Calcaneovalgus deformity (HP:0001848)4.53091331
8Unilateral renal agenesis (HP:0000122)4.38790230
9Concave nail (HP:0001598)4.31464372
10Abnormality of secondary sexual hair (HP:0009888)4.30917199
11Abnormality of the axillary hair (HP:0100134)4.30917199
12Bilateral microphthalmos (HP:0007633)4.19689174
13Femoral bowing (HP:0002980)4.13262150
14Tibial bowing (HP:0002982)4.12718402
15Deformed tarsal bones (HP:0008119)4.00931584
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.97835990
17Midline defect of the nose (HP:0004122)3.95442898
18Hypophosphatemia (HP:0002148)3.90864459
19Abnormality of the parietal bone (HP:0002696)3.84765051
20Broad distal phalanx of finger (HP:0009836)3.83592946
21Metaphyseal irregularity (HP:0003025)3.83083582
22Aplasia cutis congenita (HP:0001057)3.79627680
23Hypoplasia of the fovea (HP:0007750)3.68714634
24Aplasia/Hypoplasia of the fovea (HP:0008060)3.68714634
25Acanthocytosis (HP:0001927)3.59841593
26Rickets (HP:0002748)3.50700708
27Premature loss of primary teeth (HP:0006323)3.37394789
28Retinal dysplasia (HP:0007973)3.30907205
29Absent/shortened dynein arms (HP:0200106)3.27447879
30Dynein arm defect of respiratory motile cilia (HP:0012255)3.27447879
31Eczematoid dermatitis (HP:0000976)3.24505200
32Bone pain (HP:0002653)3.23624336
33Cutaneous finger syndactyly (HP:0010554)3.21463210
34Short middle phalanx of the 5th finger (HP:0004220)3.19194260
35Aplasia/Hypoplasia of the uvula (HP:0010293)3.10058014
36Focal motor seizures (HP:0011153)3.08149031
37Joint hemorrhage (HP:0005261)3.01508991
38Abnormality of the pubic bones (HP:0003172)2.97608517
39Renal dysplasia (HP:0000110)2.96588066
40Cortical dysplasia (HP:0002539)2.90217794
41Short humerus (HP:0005792)2.89729341
42Cutaneous syndactyly (HP:0012725)2.87421400
43Occipital encephalocele (HP:0002085)2.86221306
44Skull defect (HP:0001362)2.85533542
45Abnormality of the fovea (HP:0000493)2.82744741
46Woolly hair (HP:0002224)2.80460502
47Recurrent gram-negative bacterial infections (HP:0005420)2.78078604
48Macroglossia (HP:0000158)2.77658281
49Abnormality of the calcaneus (HP:0008364)2.73437543
50Aplasia/hypoplasia of the humerus (HP:0006507)2.71199731
51Abnormality of the 4th metacarpal (HP:0010012)2.67276736
52Abnormality of the phalanges of the hallux (HP:0010057)2.66250961
53Symphalangism affecting the phalanges of the hand (HP:0009773)2.57091742
54Spinal canal stenosis (HP:0003416)2.54356933
55Type II lissencephaly (HP:0007260)2.50712633
56Congenital, generalized hypertrichosis (HP:0004540)2.50192161
57Obstructive sleep apnea (HP:0002870)2.49160215
58Aplasia/Hypoplasia of the macula (HP:0008059)2.45524567
59Dislocated radial head (HP:0003083)2.44967072
60Fused cervical vertebrae (HP:0002949)2.43714218
61Septo-optic dysplasia (HP:0100842)2.41597115
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.40029313
63Abnormality of the middle phalanges of the toes (HP:0010183)2.36251503
64Preaxial foot polydactyly (HP:0001841)2.35626548
65Chromsome breakage (HP:0040012)2.34521565
66Abnormality of vision evoked potentials (HP:0000649)2.33763876
67Craniofacial hyperostosis (HP:0004493)2.31237542
68Recurrent bacterial skin infections (HP:0005406)2.30630472
69Tubulointerstitial fibrosis (HP:0005576)2.30004532
70Prolonged partial thromboplastin time (HP:0003645)2.29846622
71Abnormality of the distal phalanx of the thumb (HP:0009617)2.28874253
72Abnormality of the radial head (HP:0003995)2.27580195
73Cranial hyperostosis (HP:0004437)2.26589601
74Osteoarthritis (HP:0002758)2.26577953
75Aplasia/Hypoplasia affecting the retina (HP:0008061)2.26221672
76Abnormality of primary teeth (HP:0006481)2.24702765
77Renal agenesis (HP:0000104)2.24318939
78Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.23987170
79Prolonged neonatal jaundice (HP:0006579)2.22147731
80Abnormal respiratory motile cilium physiology (HP:0012261)2.21097547
81Transposition of the great arteries (HP:0001669)2.20277287
82Abnormal connection of the cardiac segments (HP:0011545)2.20277287
83Abnormal ventriculo-arterial connection (HP:0011563)2.20277287
84Abnormal rod and cone electroretinograms (HP:0008323)2.19297453
85Orthostatic hypotension (HP:0001278)2.18784681
86Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18674364
87Preauricular pit (HP:0004467)2.17332006
88Periauricular skin pits (HP:0100277)2.17332006
89Parakeratosis (HP:0001036)2.15813104
90Ectopic kidney (HP:0000086)2.15601907
91Coronal craniosynostosis (HP:0004440)2.15275805
92Split foot (HP:0001839)2.15215244
93Osteomyelitis (HP:0002754)2.15138857
94Vacuolated lymphocytes (HP:0001922)2.13863314
95Potter facies (HP:0002009)2.13847809
96Facial shape deformation (HP:0011334)2.13847809
97Lissencephaly (HP:0001339)2.13735745
98Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.12787523
99Rhinitis (HP:0012384)2.12378427
100Partial agenesis of the corpus callosum (HP:0001338)2.11208472
101Congenital ichthyosiform erythroderma (HP:0007431)2.11002880
102Abnormality of the labia minora (HP:0012880)2.08387712
103Colon cancer (HP:0003003)2.06398352
104Orchitis (HP:0100796)2.05570860
105Abnormal umbilical cord blood vessels (HP:0011403)2.03831679
106Single umbilical artery (HP:0001195)2.03831679
107Abnormality of the fetal cardiovascular system (HP:0010948)2.03831679
108Exostoses (HP:0100777)2.02083689
109Abnormality of the humeroradial joint (HP:0100744)2.01181578
110Large hands (HP:0001176)1.99611991
111Volvulus (HP:0002580)1.99043892
112Recurrent abscess formation (HP:0002722)1.98470030
113Myocardial infarction (HP:0001658)1.97339833
114Ulnar claw (HP:0001178)1.96831933
115Ectopic anus (HP:0004397)1.95395208
116Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.94567436
117Abnormal ciliary motility (HP:0012262)1.94428278
118Short 5th finger (HP:0009237)1.93999577
119Onion bulb formation (HP:0003383)1.93842574
120Absent speech (HP:0001344)1.92871934
121Prolonged QT interval (HP:0001657)1.92765093
122Recurrent sinusitis (HP:0011108)1.91804304
123Prostate neoplasm (HP:0100787)1.91732313
124Rhabdomyosarcoma (HP:0002859)1.91613284
125Gingival bleeding (HP:0000225)1.91005270
126Meckel diverticulum (HP:0002245)1.89527539
127Gastrointestinal atresia (HP:0002589)1.89020216
128Gingivitis (HP:0000230)1.88887538
129Severe Myopia (HP:0011003)1.87482227
130Cellulitis (HP:0100658)1.87057777
131Atresia of the external auditory canal (HP:0000413)1.85683085
132Recurrent skin infections (HP:0001581)1.85647735
133Distal lower limb amyotrophy (HP:0008944)1.85645496
134Hyperventilation (HP:0002883)1.84602366
135Cone-rod dystrophy (HP:0000548)1.84441015
136Postaxial foot polydactyly (HP:0001830)1.83578121
137Abnormal finger flexion creases (HP:0006143)1.83553359
138Abnormal sex determination (HP:0012244)1.83293651
139Sex reversal (HP:0012245)1.83293651
140Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.82363350
141Generalized tonic-clonic seizures (HP:0002069)1.81155371
142Overlapping toe (HP:0001845)1.80215012
143Broad phalanx (HP:0006009)1.79931379
144Carpal synostosis (HP:0009702)1.79324176
145Abnormality of the fibula (HP:0002991)1.79320139
146Broad thumb (HP:0011304)1.77725610
147Myositis (HP:0100614)1.77723954
148Colitis (HP:0002583)1.77499828
149Supranuclear gaze palsy (HP:0000605)1.77493012
150Bell-shaped thorax (HP:0001591)1.76193484
151Broad phalanges of the hand (HP:0009768)1.76017321
152Vascular calcification (HP:0004934)1.75785921
153Megaloblastic anemia (HP:0001889)1.75763438
154Decreased skull ossification (HP:0004331)1.75447393
155Abnormality of the ileum (HP:0001549)1.74783861
156Aplasia involving bones of the upper limbs (HP:0009823)1.73866340
157Aplasia of the phalanges of the hand (HP:0009802)1.73866340
158Aplasia involving bones of the extremities (HP:0009825)1.73866340
159Abnormal urine phosphate concentration (HP:0012599)1.73162173
160Myokymia (HP:0002411)1.72708734
161Absent phalangeal crease (HP:0006109)1.72391219
162Decreased central vision (HP:0007663)1.72266604
163Gonadal dysgenesis (HP:0000133)1.72082719
164Esophageal atresia (HP:0002032)1.71822001
165Abnormality of glycolipid metabolism (HP:0010969)1.71741411
166Abnormality of liposaccharide metabolism (HP:0010968)1.71741411
167Abnormality of glycosphingolipid metabolism (HP:0004343)1.71741411
168Hepatosplenomegaly (HP:0001433)1.70341731
169Abnormality of the humerus (HP:0003063)1.69996222
170Ulnar deviation of finger (HP:0009465)1.69003082
171Abnormality of the phalanges of the 5th finger (HP:0004213)1.68919289
172Abnormality of chromosome stability (HP:0003220)1.68720663
173Shallow orbits (HP:0000586)1.68653996
174Increased nuchal translucency (HP:0010880)1.67740266
175Shawl scrotum (HP:0000049)1.66703697
176Optic nerve hypoplasia (HP:0000609)1.65895427
177Recurrent cutaneous fungal infections (HP:0011370)1.65490617
178Chronic mucocutaneous candidiasis (HP:0002728)1.65490617
179Exotropia (HP:0000577)1.65310904
180Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.65009983
181Broad long bones (HP:0005622)1.64750377
182Anencephaly (HP:0002323)1.64394787
183Hip dysplasia (HP:0001385)1.63570302
184Attenuation of retinal blood vessels (HP:0007843)1.62879161
185Right ventricular cardiomyopathy (HP:0011663)1.62852435
186Sensory axonal neuropathy (HP:0003390)1.62183212
187Abnormality of Sharpey fibers (HP:0100685)1.61983527
188Fragile skin (HP:0001030)1.60486967
189Fair hair (HP:0002286)1.60458614
190Steppage gait (HP:0003376)1.60314613
191Cardiovascular calcification (HP:0011915)1.60180121
192Hypotrichosis (HP:0001006)1.59627157
193Lower limb amyotrophy (HP:0007210)1.59115123
194Focal segmental glomerulosclerosis (HP:0000097)1.59006737
195Abnormality of macrophages (HP:0004311)1.58936338
196Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.58715873
197Degeneration of the lateral corticospinal tracts (HP:0002314)1.58715873
198Chronic otitis media (HP:0000389)1.56992510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.90419726
2SIK24.92638920
3PIK3CG3.85016787
4ZAK3.76442562
5IRAK43.74248328
6MKNK13.50765068
7MAP3K123.39485865
8MST1R3.39217689
9IRAK33.29886100
10PRKD33.24205683
11MKNK23.00031812
12FGR2.79350294
13NME12.74930350
14LATS12.72664073
15TTK2.64481700
16MAP3K102.59700135
17CDC72.48828076
18NUAK12.37078100
19DYRK1B2.24796354
20PBK2.22212585
21WEE12.14331787
22INSRR2.14252005
23IRAK12.11247331
24MATK2.11184929
25MAP2K72.08679960
26IRAK21.99250867
27DMPK1.98546263
28EPHB11.93266503
29BLK1.92522698
30EPHA31.85159960
31RPS6KA41.71526173
32CSK1.70070802
33TESK21.70068998
34PLK41.68011359
35SRPK11.66083088
36PDK41.60098306
37PDK31.60098306
38EPHB21.59341389
39MAP3K41.56869747
40BRSK21.54143044
41ATR1.53805968
42JAK11.52851733
43DYRK1A1.51391507
44MUSK1.48475390
45PLK11.42007270
46FGFR41.40940641
47CCNB11.40563343
48MAPK131.35680499
49PLK31.35082532
50SIK11.34773244
51STK38L1.34153501
52WNK31.25885753
53HIPK21.24147922
54LATS21.19951674
55MAPK151.19183927
56MET1.18885684
57FER1.16290438
58NEK11.15682878
59ERN11.15533953
60CHEK21.12882409
61SIK31.11475885
62MAP2K41.09889806
63STK391.09361087
64DAPK11.05945603
65STK241.04648707
66ADRBK21.03661873
67BCKDK1.00744132
68ERBB31.00659433
69TNK20.99994437
70TNIK0.99549752
71BRD40.95721052
72PDK20.94070906
73PNCK0.93188892
74NTRK30.89426829
75PLK20.88767753
76CDK30.88067813
77CDK190.87291066
78TEC0.86713625
79DAPK20.84917662
80EPHA40.84515689
81BMPR20.83482740
82RIPK40.83411512
83YES10.79292393
84CHEK10.77971494
85RPS6KC10.76971398
86RPS6KL10.76971398
87TYK20.76880461
88KIT0.75683901
89BUB10.75657597
90RPS6KA60.74147871
91MARK10.72153111
92ATM0.71727827
93DDR20.71467107
94CLK10.70571104
95MAP3K110.69106226
96NEK20.68415835
97CHUK0.67285251
98NTRK20.65596027
99MAP4K20.64830328
100MAPKAPK50.63242002
101FES0.63016720
102CDK150.63007819
103AURKB0.62787406
104ERBB40.62736159
105BRSK10.60825839
106TAOK30.60392478
107FGFR20.60197786
108CDK180.60145083
109PRKCG0.59670494
110CDK10.59407531
111LMTK20.58199428
112GRK10.57757755
113OXSR10.57432902
114CSNK1E0.56899445
115CDK140.56121449
116EIF2AK20.55914202
117CDK20.53615577
118MAP3K60.53571760
119VRK10.53235087
120CDK11A0.52953677
121ALK0.52280380
122CSNK1A1L0.51880503
123MAP3K10.50489458
124MAP3K130.50133263
125PTK2B0.49528679
126STK160.47543085
127CSNK1A10.46791153
128DAPK30.46022350
129HCK0.46004350
130GSK3B0.45568827
131GRK70.45222745
132DYRK30.45096259
133PRKDC0.44150762
134RPS6KA20.43139271
135PAK60.42208618
136PRKCE0.41831691
137TSSK60.41807686
138MAP3K70.41290059
139SYK0.41096768
140CAMK10.40296542
141TYRO30.39831192
142MAP3K140.38989115
143ROCK20.38751250
144NTRK10.38000489
145STK30.37945314
146NME20.37695890
147WNK40.36594809
148SGK30.36409083
149MAPK70.36291117
150PRKCH0.35921450
151MINK10.35845177
152PDGFRA0.34711247
153GSK3A0.34196510
154CSNK1G10.34111394
155WNK10.33344450
156JAK20.33316059
157UHMK10.31253682
158CDK50.30621505
159PKN10.30175736
160EPHA20.27937048
161BCR0.27688904
162DYRK20.27577398
163CSNK1G30.27566384
164INSR0.27423689
165FYN0.27061129
166ADRBK10.26156183
167MAPK120.25772767
168PAK30.25033674
169FRK0.24417983
170FGFR30.24342314
171CAMK2B0.23271653
172PRPF4B0.22059589
173GRK50.21910734
174LYN0.21214165
175ROCK10.20966033
176CSNK1G20.19496965
177RPS6KA50.19094209

Predicted pathways (KEGG)

RankGene SetZ-score
1Base excision repair_Homo sapiens_hsa034103.49971893
2DNA replication_Homo sapiens_hsa030302.91493705
3Fanconi anemia pathway_Homo sapiens_hsa034602.55119914
4Cell cycle_Homo sapiens_hsa041102.47279912
5Mismatch repair_Homo sapiens_hsa034302.41143195
6Arachidonic acid metabolism_Homo sapiens_hsa005902.27489993
7mRNA surveillance pathway_Homo sapiens_hsa030152.25657843
8Homologous recombination_Homo sapiens_hsa034402.24870300
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19984562
10Hippo signaling pathway_Homo sapiens_hsa043902.19697460
11Morphine addiction_Homo sapiens_hsa050322.13264513
12GABAergic synapse_Homo sapiens_hsa047272.05889680
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05686394
14Nicotine addiction_Homo sapiens_hsa050332.01986365
15RNA transport_Homo sapiens_hsa030132.01417887
16Vitamin digestion and absorption_Homo sapiens_hsa049771.97299244
17Tryptophan metabolism_Homo sapiens_hsa003801.96739526
18Spliceosome_Homo sapiens_hsa030401.90969048
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.87819962
20Fatty acid elongation_Homo sapiens_hsa000621.87172693
21Glutamatergic synapse_Homo sapiens_hsa047241.87083268
22Basal cell carcinoma_Homo sapiens_hsa052171.84427530
23Phenylalanine metabolism_Homo sapiens_hsa003601.81217526
24African trypanosomiasis_Homo sapiens_hsa051431.81160801
25Basal transcription factors_Homo sapiens_hsa030221.79015940
26Thyroid hormone synthesis_Homo sapiens_hsa049181.74657496
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.73499242
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.67977430
29Histidine metabolism_Homo sapiens_hsa003401.66085203
30Ether lipid metabolism_Homo sapiens_hsa005651.64944163
31Protein export_Homo sapiens_hsa030601.64086087
32One carbon pool by folate_Homo sapiens_hsa006701.62540441
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60923514
34Serotonergic synapse_Homo sapiens_hsa047261.59181480
35p53 signaling pathway_Homo sapiens_hsa041151.57211238
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56672636
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.54127340
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.52066109
39Wnt signaling pathway_Homo sapiens_hsa043101.51715215
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49769097
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.48609413
42Circadian entrainment_Homo sapiens_hsa047131.47916284
43Hedgehog signaling pathway_Homo sapiens_hsa043401.46516733
44Oocyte meiosis_Homo sapiens_hsa041141.46250481
45TGF-beta signaling pathway_Homo sapiens_hsa043501.44961484
46Selenocompound metabolism_Homo sapiens_hsa004501.42811289
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.41080587
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40673998
49Phototransduction_Homo sapiens_hsa047441.38680132
50Salivary secretion_Homo sapiens_hsa049701.32171322
51Nucleotide excision repair_Homo sapiens_hsa034201.31496552
52Bladder cancer_Homo sapiens_hsa052191.30150982
53Olfactory transduction_Homo sapiens_hsa047401.25919007
54Primary bile acid biosynthesis_Homo sapiens_hsa001201.25545376
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21807571
56Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18125223
57RNA degradation_Homo sapiens_hsa030181.17728572
58ABC transporters_Homo sapiens_hsa020101.16726701
59Dopaminergic synapse_Homo sapiens_hsa047281.16568734
60Lysosome_Homo sapiens_hsa041421.15853706
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14311301
62Long-term depression_Homo sapiens_hsa047301.14015917
63Antigen processing and presentation_Homo sapiens_hsa046121.12649588
64Synaptic vesicle cycle_Homo sapiens_hsa047211.11644443
65SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11542036
66Glutathione metabolism_Homo sapiens_hsa004801.10944791
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10441454
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10347826
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08910929
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07057550
71Linoleic acid metabolism_Homo sapiens_hsa005911.04227890
72cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03926176
73MicroRNAs in cancer_Homo sapiens_hsa052061.02495428
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02381722
75Cholinergic synapse_Homo sapiens_hsa047251.01409621
76Pyrimidine metabolism_Homo sapiens_hsa002401.01129441
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00775270
78Staphylococcus aureus infection_Homo sapiens_hsa051501.00457830
79Complement and coagulation cascades_Homo sapiens_hsa046100.98701620
80beta-Alanine metabolism_Homo sapiens_hsa004100.97602498
81Regulation of autophagy_Homo sapiens_hsa041400.97132884
82Renin secretion_Homo sapiens_hsa049240.96445091
83Gastric acid secretion_Homo sapiens_hsa049710.95154075
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.95147099
85Nitrogen metabolism_Homo sapiens_hsa009100.95021103
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93887301
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92593511
88Proteasome_Homo sapiens_hsa030500.91378227
89Taste transduction_Homo sapiens_hsa047420.90696576
90Estrogen signaling pathway_Homo sapiens_hsa049150.89480489
91Cocaine addiction_Homo sapiens_hsa050300.88398633
92Oxytocin signaling pathway_Homo sapiens_hsa049210.87076017
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85449696
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84966619
95Phagosome_Homo sapiens_hsa041450.84964922
96Tyrosine metabolism_Homo sapiens_hsa003500.82980383
97Chemokine signaling pathway_Homo sapiens_hsa040620.82852395
98RNA polymerase_Homo sapiens_hsa030200.82690580
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82457175
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81438188
101Osteoclast differentiation_Homo sapiens_hsa043800.80498364
102Lysine degradation_Homo sapiens_hsa003100.80379825
103Vitamin B6 metabolism_Homo sapiens_hsa007500.80243684
104Non-homologous end-joining_Homo sapiens_hsa034500.79768361
105cAMP signaling pathway_Homo sapiens_hsa040240.78091151
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77904119
107Axon guidance_Homo sapiens_hsa043600.76990140
108Melanogenesis_Homo sapiens_hsa049160.76589936
109Other glycan degradation_Homo sapiens_hsa005110.71040937
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69298325
111Amphetamine addiction_Homo sapiens_hsa050310.68316871
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68244431
113Tight junction_Homo sapiens_hsa045300.67541670
114Insulin secretion_Homo sapiens_hsa049110.67271908
115PPAR signaling pathway_Homo sapiens_hsa033200.67078134
116Propanoate metabolism_Homo sapiens_hsa006400.66465565
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.66216514
118Dorso-ventral axis formation_Homo sapiens_hsa043200.66117963
119Long-term potentiation_Homo sapiens_hsa047200.66107244
120Fatty acid metabolism_Homo sapiens_hsa012120.64318515
121Purine metabolism_Homo sapiens_hsa002300.63266521
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.63211931
123Chemical carcinogenesis_Homo sapiens_hsa052040.63101398
124Pancreatic secretion_Homo sapiens_hsa049720.62736634
125Butanoate metabolism_Homo sapiens_hsa006500.62436158
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62259598
127Sulfur metabolism_Homo sapiens_hsa009200.62070813
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.60687070
129Parkinsons disease_Homo sapiens_hsa050120.60491473
130Thyroid cancer_Homo sapiens_hsa052160.59397864
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.57011379
132Protein digestion and absorption_Homo sapiens_hsa049740.56772169
133Gap junction_Homo sapiens_hsa045400.55212514
134Fatty acid degradation_Homo sapiens_hsa000710.55005085
135Proteoglycans in cancer_Homo sapiens_hsa052050.53622008
136GnRH signaling pathway_Homo sapiens_hsa049120.53562239
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53434664
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52949864
139Sphingolipid metabolism_Homo sapiens_hsa006000.52904621
140Retinol metabolism_Homo sapiens_hsa008300.50110059
141Arginine biosynthesis_Homo sapiens_hsa002200.50031694
142Pertussis_Homo sapiens_hsa051330.48818884
143Tuberculosis_Homo sapiens_hsa051520.48275649
144Ovarian steroidogenesis_Homo sapiens_hsa049130.48136584
145Ras signaling pathway_Homo sapiens_hsa040140.47683000
146Alcoholism_Homo sapiens_hsa050340.46446241
147AMPK signaling pathway_Homo sapiens_hsa041520.45901248
148Leishmaniasis_Homo sapiens_hsa051400.44557671
149Calcium signaling pathway_Homo sapiens_hsa040200.43668047
150Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43560862
151Hepatitis C_Homo sapiens_hsa051600.43404042
152Starch and sucrose metabolism_Homo sapiens_hsa005000.43112786
153N-Glycan biosynthesis_Homo sapiens_hsa005100.42736204
154Drug metabolism - other enzymes_Homo sapiens_hsa009830.41542202
155Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41058888
156Huntingtons disease_Homo sapiens_hsa050160.38593259
157Oxidative phosphorylation_Homo sapiens_hsa001900.37496434
158Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37004306
159Cyanoamino acid metabolism_Homo sapiens_hsa004600.34804805
160Pathways in cancer_Homo sapiens_hsa052000.29900000
161HTLV-I infection_Homo sapiens_hsa051660.29337465
162Cardiac muscle contraction_Homo sapiens_hsa042600.28083418

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