ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	detection of bacterium (GO:0016045)	9.93450919
2	detection of other organism (GO:0098543)	8.55582667
3	diol metabolic process (GO:0034311)	8.42394908
4	sphingosine metabolic process (GO:0006670)	7.99576667
5	response to phenylpropanoid (GO:0080184)	7.87760341
6	multicellular organismal water homeostasis (GO:0050891)	7.70513163
7	water homeostasis (GO:0030104)	6.56501801
8	regulation of natural killer cell differentiation (GO:0032823)	6.26699977
9	keratinization (GO:0031424)	6.17516858
10	regulation of ruffle assembly (GO:1900027)	5.87306212
11	regulation of transforming growth factor beta1 production (GO:0032908)	5.54439100
12	phospholipid scrambling (GO:0017121)	5.36642373
13	positive regulation of Rho protein signal transduction (GO:0035025)	5.23700135
14	detection of external biotic stimulus (GO:0098581)	5.23528460
15	chemical homeostasis within a tissue (GO:0048875)	4.98552464
16	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.95358783
17	keratinocyte differentiation (GO:0030216)	4.84734005
18	fatty acid elongation (GO:0030497)	4.83221209
19	peptide cross-linking (GO:0018149)	4.61899167
20	innate immune response in mucosa (GO:0002227)	4.59874173
21	antibacterial humoral response (GO:0019731)	4.59802001
22	skin morphogenesis (GO:0043589)	4.56872329
23	hormone catabolic process (GO:0042447)	4.48156280
24	molting cycle (GO:0042303)	4.40418442
25	hair cycle (GO:0042633)	4.40418442
26	sphingolipid biosynthetic process (GO:0030148)	4.40367663
27	antimicrobial humoral response (GO:0019730)	4.33588081
28	detection of biotic stimulus (GO:0009595)	4.32661961
29	epidermal cell differentiation (GO:0009913)	4.32538092
30	intermediate filament organization (GO:0045109)	4.32334356
31	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	4.31601251
32	surfactant homeostasis (GO:0043129)	4.23452043
33	negative regulation of T cell apoptotic process (GO:0070233)	4.10982534
34	negative regulation of cell fate specification (GO:0009996)	4.01511514
35	beta-amyloid metabolic process (GO:0050435)	4.00497227
36	epidermis development (GO:0008544)	3.99535679
37	regulation of cell proliferation involved in kidney development (GO:1901722)	3.99334859
38	phospholipid efflux (GO:0033700)	3.94066595
39	positive regulation of glomerulus development (GO:0090193)	3.83541707
40	mucosal immune response (GO:0002385)	3.81130580
41	chemosensory behavior (GO:0007635)	3.78997135
42	keratinocyte proliferation (GO:0043616)	3.76981997
43	primary alcohol catabolic process (GO:0034310)	3.71844844
44	organ or tissue specific immune response (GO:0002251)	3.60437973
45	peptide catabolic process (GO:0043171)	3.54742039
46	regulation of phospholipase A2 activity (GO:0032429)	3.50151255
47	intestinal epithelial cell development (GO:0060576)	3.46623908
48	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.41068813
49	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	3.38535517
50	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.33125213
51	copper ion transport (GO:0006825)	3.32107315
52	regulation of glomerulus development (GO:0090192)	3.30390158
53	membrane lipid biosynthetic process (GO:0046467)	3.23405899
54	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.19675075
55	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	3.14125549
56	fatty-acyl-CoA biosynthetic process (GO:0046949)	3.10205448
57	positive regulation of transforming growth factor beta production (GO:0071636)	3.09730224
58	ethanol metabolic process (GO:0006067)	3.07805699
59	negative regulation of stress fiber assembly (GO:0051497)	3.07704758
60	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	3.06328209
61	response to testosterone (GO:0033574)	2.99432651
62	sphingolipid metabolic process (GO:0006665)	2.99350733
63	long-chain fatty-acyl-CoA metabolic process (GO:0035336)	2.95205538
64	negative regulation of cell fate commitment (GO:0010454)	2.93929364
65	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.93921346
66	hemidesmosome assembly (GO:0031581)	2.93071639
67	negative regulation of interferon-gamma production (GO:0032689)	2.91641273
68	positive regulation of cholesterol efflux (GO:0010875)	2.90934999
69	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	2.89527577
70	negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)	2.83553079
71	centrosome localization (GO:0051642)	2.81955808
72	positive regulation of cholesterol transport (GO:0032376)	2.76548806
73	positive regulation of sterol transport (GO:0032373)	2.76548806
74	cell communication involved in cardiac conduction (GO:0086065)	2.76423270
75	negative regulation of fatty acid biosynthetic process (GO:0045717)	2.73893609
76	defense response to Gram-positive bacterium (GO:0050830)	2.73722250
77	cellular copper ion homeostasis (GO:0006878)	2.73421025
78	G-protein coupled purinergic receptor signaling pathway (GO:0035588)	2.72112199
79	T cell homeostasis (GO:0043029)	2.71831425
80	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.71534951
81	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.70531448
82	fatty-acyl-CoA metabolic process (GO:0035337)	2.69152167
83	regulation of neuron projection regeneration (GO:0070570)	2.68459398
84	regulation of axon regeneration (GO:0048679)	2.68459398
85	regulation of glomerular filtration (GO:0003093)	2.67362695
86	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.61127687
87	regulation of protein localization to cell surface (GO:2000008)	2.61001542
88	tight junction assembly (GO:0070830)	2.59728630
89	intermediate filament-based process (GO:0045103)	2.57577417
90	intermediate filament cytoskeleton organization (GO:0045104)	2.55576867
91	positive regulation of hair cycle (GO:0042635)	2.54454860
92	positive regulation of hair follicle development (GO:0051798)	2.54454860
93	neurofilament cytoskeleton organization (GO:0060052)	2.52997547
94	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	2.52005975
95	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	2.52005975
96	copper ion homeostasis (GO:0055070)	2.51703470
97	establishment of skin barrier (GO:0061436)	12.4134607
98	sphingoid metabolic process (GO:0046519)	12.2311834
99	regulation of water loss via skin (GO:0033561)	11.5750899
100	desmosome organization (GO:0002934)	10.8871409

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	8.05074674
2	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	7.74897609
3	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.60335939
4	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.55309741
5	SOX9_24532713_ChIP-Seq_HFSC_Mouse	2.46902936
6	P63_26484246_Chip-Seq_KERATINOCYTES_Human	2.36532901
7	TP53_18474530_ChIP-ChIP_U2OS_Human	2.25600979
8	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.20822591
9	SOX2_20726797_ChIP-Seq_SW620_Human	2.03268596
10	FOXO3_23340844_ChIP-Seq_DLD1_Human	2.01839876
11	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.00989658
12	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.88790104
13	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.83782987
14	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.71646486
15	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.71646486
16	TAF15_26573619_Chip-Seq_HEK293_Human	1.66848015
17	BCAT_22108803_ChIP-Seq_LS180_Human	1.66068473
18	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.65493228
19	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.58025278
20	TP63_23658742_ChIP-Seq_EP156T_Human	1.55935563
21	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.55007061
22	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.54925170
23	AR_21572438_ChIP-Seq_LNCaP_Human	1.53941116
24	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.52871729
25	AHR_22903824_ChIP-Seq_MCF-7_Human	1.52638959
26	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.46696295
27	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.45820905
28	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.44521909
29	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.42625488
30	IGF1R_20145208_ChIP-Seq_DFB_Human	1.41969353
31	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.41949317
32	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.40747308
33	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.39044021
34	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.39044021
35	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.38677277
36	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.38611266
37	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.36072541
38	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.35812521
39	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.35812521
40	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.34781490
41	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.34130870
42	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.34025002
43	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.33530551
44	ZNF263_19887448_ChIP-Seq_K562_Human	1.32025803
45	TCF4_22108803_ChIP-Seq_LS180_Human	1.29763753
46	* PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.28924941
47	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.25540985
48	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.25501995
49	GATA4_25053715_ChIP-Seq_YYC3_Human	1.23905972
50	TP53_16413492_ChIP-PET_HCT116_Human	1.23252697
51	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.21149731
52	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.20765509
53	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.19210884
54	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.18516319
55	ZNF274_21170338_ChIP-Seq_K562_Hela	1.17961633
56	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.17762247
57	RXR_22108803_ChIP-Seq_LS180_Human	1.17355771
58	* CJUN_26792858_Chip-Seq_BT549_Human	1.16672428
59	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.16274163
60	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.15985189
61	LXR_22292898_ChIP-Seq_THP-1_Human	1.13548282
62	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.11905550
63	KLF5_25053715_ChIP-Seq_YYC3_Human	1.10457265
64	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.09984901
65	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.09900814
66	ATF3_27146783_Chip-Seq_COLON_Human	1.09226151
67	GATA1_22025678_ChIP-Seq_K562_Human	1.07946087
68	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.06614937
69	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.05791296
70	RACK7_27058665_Chip-Seq_MCF-7_Human	1.02665260
71	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.99578194
72	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.99570106
73	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.98677849
74	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.98568408
75	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.96798611
76	* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.96535230
77	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.96317663
78	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.95916271
79	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.95891972
80	TP63_22573176_ChIP-Seq_HFKS_Human	0.95261633
81	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.95070548
82	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.94977541
83	P53_21459846_ChIP-Seq_SAOS-2_Human	0.92515006
84	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.92147557
85	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.90911760
86	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.90699178
87	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.87646346
88	HTT_18923047_ChIP-ChIP_STHdh_Human	0.87336243
89	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.85548039
90	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.85439841
91	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.84605830
92	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.83571313
93	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.80701551
94	SMAD4_21799915_ChIP-Seq_A2780_Human	0.79592894
95	EGR1_19032775_ChIP-ChIP_M12_Human	0.78950549
96	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.76458683
97	GATA6_25053715_ChIP-Seq_YYC3_Human	0.74790359
98	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.74737764
99	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.73898946
100	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.72799711

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002796_impaired_skin_barrier	7.08161767
2	MP0003941_abnormal_skin_development	5.76155749
3	MP0005451_abnormal_body_composition	5.15351777
4	MP0010234_abnormal_vibrissa_follicle	5.03314832
5	MP0010386_abnormal_urinary_bladder	4.45366532
6	MP0005501_abnormal_skin_physiology	4.28807499
7	MP0002009_preneoplasia	4.14881166
8	MP0005275_abnormal_skin_tensile	3.97684704
9	MP0003011_delayed_dark_adaptation	3.84234731
10	MP0004381_abnormal_hair_follicle	3.73113992
11	MP0002060_abnormal_skin_morphology	3.51723425
12	MP0010771_integument_phenotype	2.84386723
13	MP0003453_abnormal_keratinocyte_physiol	2.70859425
14	MP0004947_skin_inflammation	2.68584876
15	MP0002254_reproductive_system_inflammat	2.62657116
16	MP0002822_catalepsy	2.61865985
17	MP0000647_abnormal_sebaceous_gland	2.56455481
18	MP0001216_abnormal_epidermal_layer	2.54404772
19	MP0003191_abnormal_cellular_cholesterol	2.35139098
20	MP0000537_abnormal_urethra_morphology	2.23918660
21	MP0000377_abnormal_hair_follicle	2.19020133
22	MP0004147_increased_porphyrin_level	2.06770700
23	MP0002098_abnormal_vibrissa_morphology	2.00319716
24	MP0000579_abnormal_nail_morphology	1.98746085
25	MP0010678_abnormal_skin_adnexa	1.90433219
26	MP0003195_calcinosis	1.87043993
27	MP0003705_abnormal_hypodermis_morpholog	1.72425677
28	MP0003329_amyloid_beta_deposits	1.66715755
29	MP0001243_abnormal_dermal_layer	1.63277179
30	MP0000427_abnormal_hair_cycle	1.62761314
31	MP0004264_abnormal_extraembryonic_tissu	1.43625814
32	MP0004145_abnormal_muscle_electrophysio	1.35391165
33	MP0009379_abnormal_foot_pigmentation	1.34750363
34	MP0001191_abnormal_skin_condition	1.34741990
35	MP0001851_eye_inflammation	1.34136707
36	MP0003315_abnormal_perineum_morphology	1.32262437
37	MP0009931_abnormal_skin_appearance	1.31771606
38	MP0000467_abnormal_esophagus_morphology	1.27852835
39	MP0004185_abnormal_adipocyte_glucose	1.27070528
40	MP0004782_abnormal_surfactant_physiolog	1.18932173
41	MP0002166_altered_tumor_susceptibility	1.18631879
42	MP0000538_abnormal_urinary_bladder	1.15093246
43	MP0002234_abnormal_pharynx_morphology	1.09089638
44	MP0000383_abnormal_hair_follicle	1.08379311
45	MP0006054_spinal_hemorrhage	1.03013277
46	MP0000762_abnormal_tongue_morphology	1.02024574
47	MP0009384_cardiac_valve_regurgitation	0.99008329
48	MP0003566_abnormal_cell_adhesion	0.98457027
49	MP0000367_abnormal_coat/_hair	0.98405497
50	MP0003950_abnormal_plasma_membrane	0.87102617
51	MP0002006_tumorigenesis	0.86267490
52	MP0000604_amyloidosis	0.81208933
53	MP0001346_abnormal_lacrimal_gland	0.80875228
54	MP0001177_atelectasis	0.74873018
55	MP0001984_abnormal_olfaction	0.70545693
56	MP0000013_abnormal_adipose_tissue	0.69099162
57	MP0000003_abnormal_adipose_tissue	0.69035865
58	MP0003880_abnormal_central_pattern	0.68701617
59	MP0001340_abnormal_eyelid_morphology	0.62118378
60	MP0004019_abnormal_vitamin_homeostasis	0.60133670
61	MP0002295_abnormal_pulmonary_circulatio	0.52350860
62	MP0002249_abnormal_larynx_morphology	0.52332445
63	MP0000516_abnormal_urinary_system	0.51728125
64	MP0005367_renal/urinary_system_phenotyp	0.51728125
65	MP0005085_abnormal_gallbladder_physiolo	0.50441815
66	MP0005409_darkened_coat_color	0.48183192
67	MP0005375_adipose_tissue_phenotype	0.47023178
68	MP0002177_abnormal_outer_ear	0.46077540
69	MP0002277_abnormal_respiratory_mucosa	0.42497039
70	MP0001835_abnormal_antigen_presentation	0.41051182
71	MP0008438_abnormal_cutaneous_collagen	0.40736824
72	MP0001919_abnormal_reproductive_system	0.39897902
73	MP0006035_abnormal_mitochondrial_morpho	0.37053936
74	MP0003632_abnormal_nervous_system	0.35674053
75	MP0009046_muscle_twitch	0.35014256
76	MP0004858_abnormal_nervous_system	0.34340242
77	MP0004272_abnormal_basement_membrane	0.34048843
78	MP0000465_gastrointestinal_hemorrhage	0.33297432
79	MP0005636_abnormal_mineral_homeostasis	0.33067035
80	MP0001784_abnormal_fluid_regulation	0.31616197
81	MP0003633_abnormal_nervous_system	0.31466669
82	MP0002896_abnormal_bone_mineralization	0.30289200
83	MP0004270_analgesia	0.30043127
84	MP0003631_nervous_system_phenotype	0.29451679
85	MP0000613_abnormal_salivary_gland	0.27623186
86	MP0005023_abnormal_wound_healing	0.27464452
87	MP0005253_abnormal_eye_physiology	0.27346008
88	MP0008961_abnormal_basal_metabolism	0.26925221
89	MP0006072_abnormal_retinal_apoptosis	0.26746251
90	MP0004036_abnormal_muscle_relaxation	0.26705222
91	MP0005508_abnormal_skeleton_morphology	0.25320034
92	MP0000627_abnormal_mammary_gland	0.25025778
93	MP0005666_abnormal_adipose_tissue	0.23571703
94	MP0002282_abnormal_trachea_morphology	0.23224379
95	MP0000566_synostosis	0.22575174
96	MP0009053_abnormal_anal_canal	0.20695739
97	MP0005623_abnormal_meninges_morphology	0.20141542
98	MP0010329_abnormal_lipoprotein_level	0.19436230
99	MP0001765_abnormal_ion_homeostasis	0.19429082
100	MP0001542_abnormal_bone_strength	0.19398681

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Parakeratosis (HP:0001036)	8.55199417
2	Abnormality of nail color (HP:0100643)	6.52380143
3	Congenital ichthyosiform erythroderma (HP:0007431)	6.46474592
4	Hypotrichosis (HP:0001006)	6.02070008
5	Abnormality of secondary sexual hair (HP:0009888)	5.68232427
6	Abnormality of the axillary hair (HP:0100134)	5.68232427
7	Right ventricular cardiomyopathy (HP:0011663)	5.51410123
8	Prostate neoplasm (HP:0100787)	5.23179401
9	Testicular atrophy (HP:0000029)	5.21330514
10	Increased IgE level (HP:0003212)	5.06868540
11	Woolly hair (HP:0002224)	4.87000204
12	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	4.80336552
13	Erythema (HP:0010783)	4.55836774
14	Calf muscle hypertrophy (HP:0008981)	4.38935303
15	Palmoplantar hyperkeratosis (HP:0000972)	4.30974250
16	Natal tooth (HP:0000695)	4.24766332
17	Lip pit (HP:0100267)	4.21950664
18	Plantar hyperkeratosis (HP:0007556)	4.00276414
19	Palmar hyperkeratosis (HP:0010765)	3.96280498
20	Muscle hypertrophy of the lower extremities (HP:0008968)	3.90595495
21	Oligodontia (HP:0000677)	3.86981854
22	Hyporeflexia of lower limbs (HP:0002600)	3.64237718
23	Gonadotropin excess (HP:0000837)	3.59104478
24	Gangrene (HP:0100758)	3.54502795
25	Sparse eyelashes (HP:0000653)	3.40870381
26	Ectropion (HP:0000656)	3.38543062
27	Fragile nails (HP:0001808)	3.36544056
28	Acanthosis nigricans (HP:0000956)	3.29692371
29	Erythroderma (HP:0001019)	3.29066344
30	Advanced eruption of teeth (HP:0006288)	3.05160358
31	Eczematoid dermatitis (HP:0000976)	3.04897130
32	Pruritus (HP:0000989)	2.98379109
33	Ventricular fibrillation (HP:0001663)	2.97513275
34	Abnormal blistering of the skin (HP:0008066)	2.92957094
35	Neurofibrillary tangles (HP:0002185)	2.88373361
36	Onycholysis (HP:0001806)	2.86620201
37	Palmoplantar keratoderma (HP:0000982)	2.85733949
38	Bifid scrotum (HP:0000048)	2.85305457
39	Popliteal pterygium (HP:0009756)	2.84357693
40	Sparse scalp hair (HP:0002209)	2.74932449
41	Pustule (HP:0200039)	2.70910179
42	Dry skin (HP:0000958)	2.66524607
43	Malignant hyperthermia (HP:0002047)	2.66315603
44	Corneal erosion (HP:0200020)	2.63670356
45	Hypohidrosis (HP:0000966)	2.63250876
46	Absence seizures (HP:0002121)	2.62377866
47	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.61746494
48	Absent hair (HP:0002298)	2.59990631
49	Dry hair (HP:0011359)	2.57593096
50	Ventricular tachycardia (HP:0004756)	2.56717036
51	Nail dystrophy (HP:0008404)	2.56133541
52	Lack of skin elasticity (HP:0100679)	2.44993480
53	Dehydration (HP:0001944)	2.43030604
54	Epidermoid cyst (HP:0200040)	2.42677223
55	Anhidrosis (HP:0000970)	2.36829716
56	Hypoplastic labia majora (HP:0000059)	2.36207446
57	Cerebral inclusion bodies (HP:0100314)	2.34925292
58	Abnormal hemoglobin (HP:0011902)	2.34370206
59	Testicular neoplasm (HP:0010788)	2.32191940
60	Vascular calcification (HP:0004934)	2.29923741
61	Distal lower limb muscle weakness (HP:0009053)	2.26185033
62	Azoospermia (HP:0000027)	2.23922977
63	Curly hair (HP:0002212)	2.23799233
64	Akinesia (HP:0002304)	2.23696631
65	Abnormality of the labia majora (HP:0012881)	2.16369409
66	Abnormality of the calf musculature (HP:0001430)	2.15037833
67	Cardiovascular calcification (HP:0011915)	2.13557785
68	Abnormality of the prostate (HP:0008775)	2.11127323
69	Milia (HP:0001056)	2.07803312
70	Dialeptic seizures (HP:0011146)	2.07512856
71	Abnormality of the gastric mucosa (HP:0004295)	2.01867508
72	Ulnar claw (HP:0001178)	2.00297193
73	Hypoplasia of dental enamel (HP:0006297)	1.94411023
74	Trismus (HP:0000211)	1.93552542
75	Abnormal pancreas size (HP:0012094)	1.92964196
76	Severe Myopia (HP:0011003)	1.92457922
77	Hypoplasia of the iris (HP:0007676)	1.91315191
78	Pili torti (HP:0003777)	1.88355035
79	Alopecia of scalp (HP:0002293)	1.85445696
80	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.82874032
81	Apathy (HP:0000741)	1.82306778
82	Pterygium (HP:0001059)	1.82231419
83	Areflexia of lower limbs (HP:0002522)	1.82049962
84	Neonatal death (HP:0003811)	1.80499249
85	Hypergammaglobulinemia (HP:0010702)	1.78505353
86	Fasciculations (HP:0002380)	1.77816977
87	Sepsis (HP:0100806)	1.76051730
88	Skin pits (HP:0100276)	1.73194419
89	Labial hypoplasia (HP:0000066)	1.69410904
90	Xerostomia (HP:0000217)	1.68978115
91	Increased cerebral lipofuscin (HP:0011813)	1.65526060
92	Tapered finger (HP:0001182)	1.64071248
93	Corneal dystrophy (HP:0001131)	1.63088431
94	Diminished motivation (HP:0000745)	1.63051000
95	Stenosis of the external auditory canal (HP:0000402)	1.62905711
96	Disinhibition (HP:0000734)	1.61011512
97	Abnormality of glycolipid metabolism (HP:0010969)	1.60656325
98	Abnormality of liposaccharide metabolism (HP:0010968)	1.60656325
99	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.60656325
100	Hoarse voice (HP:0001609)	1.59965082

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNK2	5.74733616
2	FER	4.85236440
3	MAP3K2	3.56408941
4	LATS1	3.34412393
5	BCR	3.12828537
6	RIPK4	2.99784269
7	EIF2AK3	2.90900649
8	MST4	2.84593541
9	MST1R	2.48118885
10	MAPKAPK3	2.26385455
11	MAP3K3	2.21951520
12	LATS2	2.20896342
13	EPHB2	2.12133185
14	CASK	2.11883644
15	PKN2	2.06660574
16	TRPM7	1.77044442
17	RPS6KB2	1.61703173
18	TESK1	1.60820413
19	EPHA4	1.54788235
20	GRK1	1.51638458
21	LIMK1	1.32350931
22	AURKA	1.29460800
23	ITK	1.23887992
24	PAK3	1.20090150
25	ERN1	1.19193320
26	LRRK2	1.18858030
27	DYRK1B	1.17638779
28	TEC	1.16514852
29	PIM2	1.15643800
30	EPHA2	1.14556381
31	ERBB3	1.12730828
32	FLT3	1.12723060
33	FGFR1	1.12041085
34	NTRK1	1.09399750
35	PTK6	1.08677998
36	ERBB4	1.04342314
37	MAPKAPK5	0.97318362
38	CDK19	0.95351845
39	CDK5	0.93126913
40	PKN1	0.92291571
41	TBK1	0.90899406
42	ERBB2	0.89153051
43	PRKCE	0.84910901
44	BRD4	0.84550584
45	PIK3CG	0.83361603
46	TNIK	0.77211758
47	PIK3CA	0.76365504
48	GRK5	0.74112308
49	PDK2	0.73754339
50	OXSR1	0.72934738
51	DYRK3	0.71688318
52	DYRK1A	0.64376518
53	STK39	0.62948084
54	STK38L	0.62662154
55	PDGFRB	0.61016747
56	CSNK1D	0.59463493
57	TTN	0.58303693
58	MAP3K7	0.55707257
59	BTK	0.53767273
60	BMX	0.53436100
61	MET	0.52943794
62	HIPK2	0.50862615
63	EPHA3	0.50841848
64	PDGFRA	0.49092221
65	LMTK2	0.47876348
66	MAP3K1	0.47570245
67	CDK7	0.46060853
68	BMPR2	0.46028902
69	UHMK1	0.43013646
70	STK10	0.42854479
71	ADRBK1	0.42612465
72	MATK	0.42214536
73	PRKCG	0.41571885
74	MAPK4	0.41145029
75	RPS6KA1	0.37858881
76	ABL1	0.37748376
77	SRC	0.35845728
78	MINK1	0.35239871
79	PRKCZ	0.34788606
80	YES1	0.34087392
81	EPHB1	0.32525470
82	MAPKAPK2	0.31986835
83	GSK3A	0.31402856
84	MAP2K4	0.30959307
85	NEK6	0.30880369
86	MAP2K1	0.30791510
87	ARAF	0.29196139
88	STK11	0.29148544
89	CSNK1E	0.28430946
90	MAPK10	0.26973330
91	PRKD1	0.26818541
92	CAMK2G	0.26724766
93	EGFR	0.26532899
94	PRKCA	0.25899724
95	STK38	0.25726737
96	MAP3K14	0.25056092
97	MAPK15	0.25013607
98	MAPK9	0.24713635
99	WNK1	0.24295139
100	MARK1	0.23804628

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sphingolipid metabolism_Homo sapiens_hsa00600	5.13181721
2	Linoleic acid metabolism_Homo sapiens_hsa00591	3.48202943
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.41122762
4	Phenylalanine metabolism_Homo sapiens_hsa00360	2.76747335
5	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.66998310
6	Collecting duct acid secretion_Homo sapiens_hsa04966	2.60011741
7	Histidine metabolism_Homo sapiens_hsa00340	2.55505421
8	Fatty acid elongation_Homo sapiens_hsa00062	2.41894542
9	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.29012007
10	Ether lipid metabolism_Homo sapiens_hsa00565	2.28543781
11	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.25878115
12	Fat digestion and absorption_Homo sapiens_hsa04975	1.90786723
13	Sphingolipid signaling pathway_Homo sapiens_hsa04071	1.64322427
14	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.61749949
15	Tyrosine metabolism_Homo sapiens_hsa00350	1.61733910
16	ABC transporters_Homo sapiens_hsa02010	1.61178208
17	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.60387402
18	Tight junction_Homo sapiens_hsa04530	1.55855381
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.53631562
20	Mineral absorption_Homo sapiens_hsa04978	1.50396038
21	Vibrio cholerae infection_Homo sapiens_hsa05110	1.43975997
22	Chemical carcinogenesis_Homo sapiens_hsa05204	1.43447015
23	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.43445020
24	Lysosome_Homo sapiens_hsa04142	1.24689825
25	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.17831173
26	Retinol metabolism_Homo sapiens_hsa00830	1.14844450
27	beta-Alanine metabolism_Homo sapiens_hsa00410	1.14174454
28	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.10510401
29	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.05786607
30	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.05771249
31	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.05680342
32	ErbB signaling pathway_Homo sapiens_hsa04012	1.01488044
33	Melanogenesis_Homo sapiens_hsa04916	1.01130372
34	Axon guidance_Homo sapiens_hsa04360	1.01079323
35	Glutathione metabolism_Homo sapiens_hsa00480	1.00406020
36	Fatty acid degradation_Homo sapiens_hsa00071	0.97591548
37	Adherens junction_Homo sapiens_hsa04520	0.92298266
38	Thyroid cancer_Homo sapiens_hsa05216	0.91715295
39	Cocaine addiction_Homo sapiens_hsa05030	0.89504236
40	Pancreatic secretion_Homo sapiens_hsa04972	0.89077200
41	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.86455216
42	Rheumatoid arthritis_Homo sapiens_hsa05323	0.82381330
43	Fatty acid metabolism_Homo sapiens_hsa01212	0.81151788
44	Steroid biosynthesis_Homo sapiens_hsa00100	0.76524714
45	PPAR signaling pathway_Homo sapiens_hsa03320	0.75222933
46	Amphetamine addiction_Homo sapiens_hsa05031	0.74559237
47	Long-term potentiation_Homo sapiens_hsa04720	0.72289999
48	Ribosome_Homo sapiens_hsa03010	0.71493079
49	Pertussis_Homo sapiens_hsa05133	0.70984060
50	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.68465992
51	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.65628311
52	Gastric acid secretion_Homo sapiens_hsa04971	0.64760350
53	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.64503336
54	Hepatitis C_Homo sapiens_hsa05160	0.63387719
55	Phagosome_Homo sapiens_hsa04145	0.62700273
56	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.61527030
57	Renin secretion_Homo sapiens_hsa04924	0.60247590
58	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.59876661
59	Rap1 signaling pathway_Homo sapiens_hsa04015	0.59576850
60	Basal cell carcinoma_Homo sapiens_hsa05217	0.58114642
61	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.57353904
62	Alzheimers disease_Homo sapiens_hsa05010	0.56633104
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.56622487
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.55953107
65	Hippo signaling pathway_Homo sapiens_hsa04390	0.55566806
66	Dopaminergic synapse_Homo sapiens_hsa04728	0.48566230
67	Arginine biosynthesis_Homo sapiens_hsa00220	0.47918483
68	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47245270
69	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.44606600
70	Estrogen signaling pathway_Homo sapiens_hsa04915	0.43237441
71	ECM-receptor interaction_Homo sapiens_hsa04512	0.42864383
72	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.41880781
73	Nitrogen metabolism_Homo sapiens_hsa00910	0.41528340
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40091406
75	GnRH signaling pathway_Homo sapiens_hsa04912	0.39380698
76	Ras signaling pathway_Homo sapiens_hsa04014	0.39212392
77	Bile secretion_Homo sapiens_hsa04976	0.39118158
78	Gap junction_Homo sapiens_hsa04540	0.39049246
79	Proteoglycans in cancer_Homo sapiens_hsa05205	0.38414227
80	Oxidative phosphorylation_Homo sapiens_hsa00190	0.38211215
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.37985797
82	Propanoate metabolism_Homo sapiens_hsa00640	0.37515679
83	Cholinergic synapse_Homo sapiens_hsa04725	0.37225830
84	Glutamatergic synapse_Homo sapiens_hsa04724	0.37083299
85	Complement and coagulation cascades_Homo sapiens_hsa04610	0.36682208
86	Insulin secretion_Homo sapiens_hsa04911	0.35907545
87	Wnt signaling pathway_Homo sapiens_hsa04310	0.35178884
88	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.35089658
89	Peroxisome_Homo sapiens_hsa04146	0.34433219
90	Prostate cancer_Homo sapiens_hsa05215	0.31687164
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.31225533
92	African trypanosomiasis_Homo sapiens_hsa05143	0.30986580
93	Bladder cancer_Homo sapiens_hsa05219	0.30606125
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.30588616
95	Salivary secretion_Homo sapiens_hsa04970	0.30479414
96	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.28968638
97	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.28272928
98	Amoebiasis_Homo sapiens_hsa05146	0.27848201
99	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.27705049
100	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.27662295

LIPK

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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