LIPN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene encodes a lipase that is highly expressed in granular keratinocytes in the epidermis, and plays a role in the differentiation of keratinocytes. Mutations in this gene are associated with lamellar ichthyosis type 4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)7.80958615
2regulation of water loss via skin (GO:0033561)6.90237888
3positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.78941356
4positive regulation of gamma-delta T cell activation (GO:0046645)5.47167020
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.26348642
6detection of other organism (GO:0098543)5.18711004
7cellular extravasation (GO:0045123)5.12718078
8negative regulation of interleukin-12 production (GO:0032695)5.07660551
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.05254416
10positive regulation by organism of defense response of other organism involved in symbiotic interact5.05254416
11modulation by symbiont of host immune response (GO:0052553)5.05254416
12positive regulation by symbiont of host defense response (GO:0052509)5.05254416
13modulation by symbiont of host defense response (GO:0052031)5.05254416
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.05254416
15regulation of dendritic cell antigen processing and presentation (GO:0002604)4.96638607
16positive regulation of antigen processing and presentation (GO:0002579)4.93271107
17detection of bacterium (GO:0016045)4.91397898
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.81355576
19negative regulation of cell killing (GO:0031342)4.81355576
20multicellular organismal water homeostasis (GO:0050891)4.79862754
21positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.71742089
22neutrophil activation involved in immune response (GO:0002283)4.53433867
23lipoxygenase pathway (GO:0019372)4.43727631
24positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.43350830
25regulation of interferon-beta biosynthetic process (GO:0045357)4.33355982
26hydrogen peroxide biosynthetic process (GO:0050665)4.32756665
27leukocyte aggregation (GO:0070486)4.28982666
28regulation of B cell receptor signaling pathway (GO:0050855)4.19746286
29production of molecular mediator involved in inflammatory response (GO:0002532)4.17855813
30regulation of T-helper 1 cell differentiation (GO:0045625)4.15680416
31positive regulation of T-helper 1 type immune response (GO:0002827)4.08993047
32regulation of gamma-delta T cell activation (GO:0046643)4.08436222
33regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.05414727
34response to host (GO:0075136)4.03423124
35response to host defenses (GO:0052200)4.03423124
36response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.03423124
37water homeostasis (GO:0030104)4.03277094
38positive regulation of interferon-alpha production (GO:0032727)4.00914445
39response to peptidoglycan (GO:0032494)3.98615307
40regulation of antigen processing and presentation (GO:0002577)3.97627973
41myeloid leukocyte mediated immunity (GO:0002444)3.96486974
42positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.95093836
43immunoglobulin mediated immune response (GO:0016064)3.94436018
44G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.87675232
45positive regulation of cellular amide metabolic process (GO:0034250)3.83973236
46reactive oxygen species biosynthetic process (GO:1903409)3.79402536
47regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.79226433
48regulation of interferon-alpha production (GO:0032647)3.75467124
49long-chain fatty acid biosynthetic process (GO:0042759)3.75335230
50wound healing, spreading of epidermal cells (GO:0035313)3.68543720
51heterotypic cell-cell adhesion (GO:0034113)3.64091249
52low-density lipoprotein particle clearance (GO:0034383)3.63585058
53superoxide anion generation (GO:0042554)3.61138024
54leukocyte migration involved in inflammatory response (GO:0002523)3.59754921
55negative regulation of interleukin-17 production (GO:0032700)3.57527072
56detection of external biotic stimulus (GO:0098581)3.57150558
57respiratory burst (GO:0045730)3.56916306
58negative regulation of lymphocyte mediated immunity (GO:0002707)3.53551918
59regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.52844554
60macrophage activation involved in immune response (GO:0002281)3.47764810
61positive regulation of Cdc42 GTPase activity (GO:0043089)3.46330638
62negative regulation of T cell mediated immunity (GO:0002710)3.44671973
63positive regulation of NF-kappaB import into nucleus (GO:0042346)3.42613336
64regulation of mast cell activation (GO:0033003)3.36412479
65negative regulation of interleukin-8 production (GO:0032717)3.34839425
66regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.34411737
67regulation of interleukin-8 biosynthetic process (GO:0045414)3.32696431
68keratinization (GO:0031424)3.30904989
69germinal center formation (GO:0002467)3.30603114
70positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.30347986
71regulation of interleukin-6 biosynthetic process (GO:0045408)3.28542897
72regulation of T-helper 1 type immune response (GO:0002825)3.27710095
73regulation of transforming growth factor beta1 production (GO:0032908)3.27548365
74regulation of mast cell activation involved in immune response (GO:0033006)3.24550161
75antigen processing and presentation of endogenous antigen (GO:0019883)3.24480875
76regulation of macrophage cytokine production (GO:0010935)3.22890781
77regulation of cholesterol storage (GO:0010885)3.22614925
78positive regulation of cholesterol efflux (GO:0010875)3.22349809
79phagosome maturation (GO:0090382)3.21240588
80T-helper 1 type immune response (GO:0042088)3.20776876
81regulation of gamma-delta T cell differentiation (GO:0045586)3.20395721
82negative regulation of interleukin-1 production (GO:0032692)3.18575095
83myeloid cell activation involved in immune response (GO:0002275)3.17934648
84regulation of T-helper 2 cell differentiation (GO:0045628)3.17530544
85antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.17007818
86defense response to protozoan (GO:0042832)3.16843167
87neutrophil chemotaxis (GO:0030593)3.16351826
88positive regulation of toll-like receptor signaling pathway (GO:0034123)3.15311294
89regulation of interleukin-12 biosynthetic process (GO:0045075)3.14665305
90lipopolysaccharide-mediated signaling pathway (GO:0031663)3.14546278
91keratinocyte differentiation (GO:0030216)3.12845876
92positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.12781882
93response to muramyl dipeptide (GO:0032495)3.12090500
94negative regulation of interleukin-1 beta production (GO:0032691)3.10392184
95positive regulation of glomerulus development (GO:0090193)3.10300099
96granulocyte activation (GO:0036230)3.10070667
97positive regulation of mast cell activation (GO:0033005)3.08413629
98neutrophil migration (GO:1990266)3.08124391
99regulation of myeloid leukocyte mediated immunity (GO:0002886)3.07832860
100negative regulation of leukocyte mediated immunity (GO:0002704)3.06314123
101detection of biotic stimulus (GO:0009595)3.05924520
102positive regulation of interleukin-1 beta secretion (GO:0050718)3.04103760
103regulation of interleukin-17 production (GO:0032660)3.03700453
104negative regulation of toll-like receptor signaling pathway (GO:0034122)3.03607248
105dendritic cell migration (GO:0036336)3.03357515
106negative regulation of interleukin-6 production (GO:0032715)3.02315350
107positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.99317730
108response to host immune response (GO:0052572)2.98842217
109response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.98842217
110regulation of natural killer cell differentiation (GO:0032823)2.98520304
111regulation of leukocyte degranulation (GO:0043300)2.97462948
112regulation of mononuclear cell migration (GO:0071675)2.95815365
113myeloid leukocyte activation (GO:0002274)2.95046463
114positive regulation of chemokine biosynthetic process (GO:0045080)2.94033472
115neutrophil activation (GO:0042119)2.92481766
116microglial cell activation (GO:0001774)2.90097708
117natural killer cell mediated cytotoxicity (GO:0042267)2.87871950
118natural killer cell mediated immunity (GO:0002228)2.87871950
119regulation of tolerance induction (GO:0002643)2.87095919
120response to protozoan (GO:0001562)2.85872731
121regulation of toll-like receptor signaling pathway (GO:0034121)2.83809295
122positive regulation of mast cell activation involved in immune response (GO:0033008)2.83714140
123positive regulation of mast cell degranulation (GO:0043306)2.83714140
124positive regulation of cholesterol transport (GO:0032376)2.83109010
125positive regulation of sterol transport (GO:0032373)2.83109010
126cytokine secretion (GO:0050663)2.82917923
127eosinophil chemotaxis (GO:0048245)2.81497922
128positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.81019006
129positive regulation of interleukin-1 secretion (GO:0050716)2.80828647
130positive regulation of interleukin-12 production (GO:0032735)2.79840588
131wound healing, spreading of cells (GO:0044319)2.78372861
132antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.77951429
133positive regulation of interleukin-1 production (GO:0032732)2.77702505
134negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.77610104
135I-kappaB phosphorylation (GO:0007252)2.77296247
136response to fungus (GO:0009620)2.74651988
137macrophage activation (GO:0042116)2.73655486
138monocyte chemotaxis (GO:0002548)2.73620437
139G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.71728113
140sphingosine metabolic process (GO:0006670)2.69337219
141positive regulation of interleukin-6 production (GO:0032755)2.68116983
142positive regulation of macrophage cytokine production (GO:0060907)2.67376619
143B cell mediated immunity (GO:0019724)2.67184083
144positive regulation of interleukin-1 beta production (GO:0032731)2.66074708
145regulation of NF-kappaB import into nucleus (GO:0042345)2.65247984
146neutrophil mediated immunity (GO:0002446)2.65223141
147dendritic cell differentiation (GO:0097028)2.65190586
148detection of molecule of bacterial origin (GO:0032490)2.64290922
149positive regulation of glycoprotein biosynthetic process (GO:0010560)2.64151961
150regulation of interleukin-1 beta secretion (GO:0050706)2.61906483
151myeloid dendritic cell differentiation (GO:0043011)2.61887237
152regulation of interleukin-8 secretion (GO:2000482)2.61655931
153regulation of mast cell degranulation (GO:0043304)2.61638452
154cellular response to zinc ion (GO:0071294)2.61511868

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.84247268
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.97554905
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.52717334
4Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.33562065
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.33493019
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.97817092
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.70967156
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.69602313
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.39392390
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.99142880
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.93587392
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.60445097
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.56935898
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.47052771
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.45004095
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.43935664
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.43331230
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.40355708
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.33288984
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.24034428
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.15174369
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13745356
23P63_26484246_Chip-Seq_KERATINOCYTES_Human1.92252268
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.90892604
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.88114195
26PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.87538227
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77404640
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.76206591
29CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.75871286
30VDR_21846776_ChIP-Seq_THP-1_Human1.75208791
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.74486695
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73059222
33SOX2_20726797_ChIP-Seq_SW620_Human1.72495934
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71627580
35MYB_26560356_Chip-Seq_TH1_Human1.67092206
36CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64493406
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63033517
38GATA1_22025678_ChIP-Seq_K562_Human1.62823025
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62378915
40PU_27001747_Chip-Seq_BMDM_Mouse1.61978038
41PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59766266
42VDR_24787735_ChIP-Seq_THP-1_Human1.58176997
43TCF7_22412390_ChIP-Seq_EML_Mouse1.58141108
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.56335874
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53605996
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50741868
47TP53_18474530_ChIP-ChIP_U2OS_Human1.50606249
48UTX_26944678_Chip-Seq_JUKART_Human1.49262029
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47534478
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45495665
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45451556
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45451556
53CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.45132304
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42383841
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41896871
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40345174
57CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38133061
58SPI1_23547873_ChIP-Seq_NB4_Human1.37921536
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37805599
60NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37805599
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.36215064
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35125477
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34875581
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34777297
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.33954866
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29505478
67CJUN_26792858_Chip-Seq_BT549_Human1.29264170
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28661533
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28623490
70GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26928513
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26000171
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22675696
73VDR_24763502_ChIP-Seq_THP-1_Human1.21856259
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21740297
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19215675
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18726301
77MYC_22102868_ChIP-Seq_BL_Human1.14796187
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.14592305
79SPI1_23127762_ChIP-Seq_K562_Human1.13931788
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13529613
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.11585811
82KDM2B_26808549_Chip-Seq_DND41_Human1.11546672
83* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11350189
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07932084
85RUNX_20019798_ChIP-Seq_JUKART_Human1.06722434
86TP63_23658742_ChIP-Seq_EP156T_Human1.05588935
87PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05281779
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05122985
89FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03875524
90MAF_26560356_Chip-Seq_TH2_Human1.03562829
91GATA3_26560356_Chip-Seq_TH2_Human1.02744641
92MYB_26560356_Chip-Seq_TH2_Human1.02559326
93JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01472003
94RXR_22108803_ChIP-Seq_LS180_Human1.00645168
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00523712
96ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99080383
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98624102
98GATA2_19941826_ChIP-Seq_K562_Human0.97570931
99CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96065187
100GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95392701
101GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95289795
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94507886
103GATA4_25053715_ChIP-Seq_YYC3_Human0.94100024
104VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93335603
105ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.92928121
106FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91771198
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91507967
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91475391
109IGF1R_20145208_ChIP-Seq_DFB_Human0.91041748
110RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90819547
111RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89920902
112GATA2_21666600_ChIP-Seq_HMVEC_Human0.89816738
113NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89596275
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89582657
115SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88789794
116ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88300406
117GATA1_19941826_ChIP-Seq_K562_Human0.88016991
118LXR_22158963_ChIP-Seq_LIVER_Mouse0.87287979
119GATA3_27048872_Chip-Seq_THYMUS_Human0.86812626
120CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86318567
121KDM2B_26808549_Chip-Seq_JURKAT_Human0.85095212
122GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84245831
123ESR1_20079471_ChIP-ChIP_T-47D_Human0.83867585
124BCOR_27268052_Chip-Seq_Bcells_Human0.83729514
125FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83453388
126SMRT_27268052_Chip-Seq_Bcells_Human0.81414123
127GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81395881
128MAF_26560356_Chip-Seq_TH1_Human0.79443224
129SCL_19346495_ChIP-Seq_HPC-7_Human0.78675067
130TP53_16413492_ChIP-PET_HCT116_Human0.78607732
131EGR1_19032775_ChIP-ChIP_M12_Human0.78535924
132FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77375870
133FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.77260370
134* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.77190643
135PU.1_20513432_ChIP-Seq_Bcells_Mouse0.76838994
136PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76579342
137ELK3_25401928_ChIP-Seq_HUVEC_Human0.76516692
138KLF5_25053715_ChIP-Seq_YYC3_Human0.76335275
139ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.76074525
140SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.75343317
141KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.74813482
142UBF1/2_26484160_Chip-Seq_HMECs_Human0.74613568

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier4.57931531
2MP0003941_abnormal_skin_development3.89379182
3MP0004947_skin_inflammation3.72321607
4MP0005451_abnormal_body_composition3.43580592
5MP0010234_abnormal_vibrissa_follicle3.29282745
6MP0005275_abnormal_skin_tensile3.21453274
7MP0003191_abnormal_cellular_cholesterol3.09970425
8MP0006082_CNS_inflammation2.98408959
9MP0001835_abnormal_antigen_presentation2.94199652
10MP0003303_peritoneal_inflammation2.78091953
11MP0003436_decreased_susceptibility_to2.72771868
12MP0002254_reproductive_system_inflammat2.59438538
13MP0005501_abnormal_skin_physiology2.58144512
14MP0002419_abnormal_innate_immunity2.51744483
15MP0005058_abnormal_lysosome_morphology2.45887016
16MP0000685_abnormal_immune_system2.43005662
17MP0002148_abnormal_hypersensitivity_rea2.41080872
18MP0008260_abnormal_autophagy2.32113024
19MP0005025_abnormal_response_to2.31520827
20MP0005000_abnormal_immune_tolerance2.21579043
21MP0003705_abnormal_hypodermis_morpholog2.19725201
22MP0009785_altered_susceptibility_to2.19490879
23MP0003724_increased_susceptibility_to2.18946119
24MP0009278_abnormal_bone_marrow2.14908946
25MP0004510_myositis2.04818107
26MP0004782_abnormal_surfactant_physiolog1.93832804
27MP0002452_abnormal_antigen_presenting1.92466500
28MP0001216_abnormal_epidermal_layer1.88517092
29MP0000604_amyloidosis1.88310822
30MP0008004_abnormal_stomach_pH1.85470151
31MP0002132_abnormal_respiratory_system1.76246702
32MP0005464_abnormal_platelet_physiology1.71429033
33MP0002060_abnormal_skin_morphology1.71246966
34MP0005387_immune_system_phenotype1.71140405
35MP0001790_abnormal_immune_system1.71140405
36MP0003075_altered_response_to1.68488822
37MP0002723_abnormal_immune_serum1.66277438
38MP0009333_abnormal_splenocyte_physiolog1.65852507
39MP0001533_abnormal_skeleton_physiology1.65053154
40MP0001800_abnormal_humoral_immune1.64267909
41MP0003453_abnormal_keratinocyte_physiol1.61111171
42MP0001851_eye_inflammation1.57503928
43MP0003172_abnormal_lysosome_physiology1.55889771
44MP0003448_altered_tumor_morphology1.53108137
45MP0001545_abnormal_hematopoietic_system1.51400053
46MP0005397_hematopoietic_system_phenotyp1.51400053
47MP0001819_abnormal_immune_cell1.50023275
48MP0010771_integument_phenotype1.50006034
49MP0002420_abnormal_adaptive_immunity1.49266850
50MP0000465_gastrointestinal_hemorrhage1.45133701
51MP0002405_respiratory_system_inflammati1.44677439
52MP0003763_abnormal_thymus_physiology1.43492055
53MP0004185_abnormal_adipocyte_glucose1.40689212
54MP0005671_abnormal_response_to1.39843031
55MP0001845_abnormal_inflammatory_respons1.38935941
56MP0010678_abnormal_skin_adnexa1.38857362
57MP0002277_abnormal_respiratory_mucosa1.38457170
58MP0009764_decreased_sensitivity_to1.38100737
59MP0003690_abnormal_glial_cell1.36666325
60MP0004883_abnormal_blood_vessel1.36628241
61MP0005174_abnormal_tail_pigmentation1.28700184
62MP0003566_abnormal_cell_adhesion1.26790960
63MP0002166_altered_tumor_susceptibility1.26052208
64MP0005166_decreased_susceptibility_to1.25461731
65MP0002722_abnormal_immune_system1.25443928
66MP0002138_abnormal_hepatobiliary_system1.25226739
67MP0004381_abnormal_hair_follicle1.22568616
68MP0002998_abnormal_bone_remodeling1.21433835
69MP0000689_abnormal_spleen_morphology1.20013495
70MP0005167_abnormal_blood-brain_barrier1.16906520
71MP0000015_abnormal_ear_pigmentation1.11933050
72MP0000569_abnormal_digit_pigmentation1.11167186
73MP0009931_abnormal_skin_appearance1.10097110
74MP0010155_abnormal_intestine_physiology1.09731255
75MP0003221_abnormal_cardiomyocyte_apopto1.08982469
76MP0008469_abnormal_protein_level1.08565849
77MP0002332_abnormal_exercise_endurance1.08390010
78MP0005076_abnormal_cell_differentiation1.07003459
79MP0005164_abnormal_response_to1.06219411
80MP0003866_abnormal_defecation1.06206075
81MP0000343_altered_response_to1.05212756
82MP0003828_pulmonary_edema1.04025835
83MP0001853_heart_inflammation1.02149400
84MP0000858_altered_metastatic_potential1.00668983
85MP0004484_altered_response_of0.98836907
86MP0001191_abnormal_skin_condition0.98716123
87MP0005310_abnormal_salivary_gland0.98569989
88MP0003195_calcinosis0.98010924
89MP0002098_abnormal_vibrissa_morphology0.97417132
90MP0010352_gastrointestinal_tract_polyps0.96752927
91MP0000703_abnormal_thymus_morphology0.93196319
92MP0005647_abnormal_sex_gland0.93177766
93MP0000383_abnormal_hair_follicle0.92077260
94MP0002090_abnormal_vision0.91361522
95MP0000647_abnormal_sebaceous_gland0.91180485
96MP0000716_abnormal_immune_system0.90616272
97MP0003183_abnormal_peptide_metabolism0.90276918
98MP0003300_gastrointestinal_ulcer0.89664987
99MP0000377_abnormal_hair_follicle0.89311642
100MP0009763_increased_sensitivity_to0.89304676
101MP0009765_abnormal_xenobiotic_induced0.86926834
102MP0002006_tumorigenesis0.85339028
103MP0005257_abnormal_intraocular_pressure0.82568206
104MP0003045_fibrosis0.81975813
105MP0004130_abnormal_muscle_cell0.79371030
106MP0010386_abnormal_urinary_bladder0.78473614
107MP0010307_abnormal_tumor_latency0.78232648
108MP0003950_abnormal_plasma_membrane0.75694408
109MP0008438_abnormal_cutaneous_collagen0.74659597
110MP0005390_skeleton_phenotype0.74188068
111MP0005075_abnormal_melanosome_morpholog0.73648584
112MP0001346_abnormal_lacrimal_gland0.73194327
113MP0002009_preneoplasia0.72625991
114MP0001243_abnormal_dermal_layer0.72419659
115MP0000367_abnormal_coat/_hair0.72387014
116MP0000249_abnormal_blood_vessel0.72281476
117MP0002933_joint_inflammation0.72003585
118MP0001873_stomach_inflammation0.70279435
119MP0003656_abnormal_erythrocyte_physiolo0.68357799
120MP0002429_abnormal_blood_cell0.66664267
121MP0004808_abnormal_hematopoietic_stem0.66294549
122MP0000920_abnormal_myelination0.65447906
123MP0002398_abnormal_bone_marrow0.65172452
124MP0000579_abnormal_nail_morphology0.65159602
125MP0006054_spinal_hemorrhage0.65128208
126MP0000372_irregular_coat_pigmentation0.64251677
127MP0009840_abnormal_foam_cell0.64188457
128MP0003091_abnormal_cell_migration0.63213528
129MP0002396_abnormal_hematopoietic_system0.63114547
130MP0000427_abnormal_hair_cycle0.62951817
131MP0001663_abnormal_digestive_system0.62395931
132MP0000371_diluted_coat_color0.61350422
133MP0005388_respiratory_system_phenotype0.58466326
134MP0002133_abnormal_respiratory_system0.58466326

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)8.97195566
2Recurrent abscess formation (HP:0002722)6.55270816
3Recurrent gram-negative bacterial infections (HP:0005420)5.96553703
4Increased cerebral lipofuscin (HP:0011813)5.73496444
5Recurrent bacterial skin infections (HP:0005406)5.50214324
6Congenital ichthyosiform erythroderma (HP:0007431)5.06260613
7Vacuolated lymphocytes (HP:0001922)4.81991554
8Keratoconjunctivitis sicca (HP:0001097)4.76333121
9Increased neuronal autofluorescent lipopigment (HP:0002074)4.75309372
10Increased IgE level (HP:0003212)4.75289083
11Abnormality of macrophages (HP:0004311)4.58951208
12Keratoconjunctivitis (HP:0001096)4.37418001
13Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.29407706
14Pustule (HP:0200039)4.15229915
15Gastrointestinal infarctions (HP:0005244)4.14375159
16Gingivitis (HP:0000230)3.89209366
17Systemic lupus erythematosus (HP:0002725)3.86994364
18Mediastinal lymphadenopathy (HP:0100721)3.79467808
19Amyloidosis (HP:0011034)3.78578643
20* Gangrene (HP:0100758)3.58059121
21Episodic fever (HP:0001954)3.57544627
22Recurrent skin infections (HP:0001581)3.56078394
23Peritonitis (HP:0002586)3.40957694
24Urticaria (HP:0001025)3.39984620
25Erythema (HP:0010783)3.36965738
26Encephalitis (HP:0002383)3.36517607
27Thick nail (HP:0001805)3.35233268
28Axonal loss (HP:0003447)3.34492071
29Periodontitis (HP:0000704)3.31042847
30Spontaneous hematomas (HP:0007420)3.28230936
31Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.22868230
32Chronic obstructive pulmonary disease (HP:0006510)3.19614091
33Obstructive lung disease (HP:0006536)3.19614091
34Hemoptysis (HP:0002105)3.18000620
35Myositis (HP:0100614)3.17768231
36Abnormality of liposaccharide metabolism (HP:0010968)3.10308388
37Abnormality of glycosphingolipid metabolism (HP:0004343)3.10308388
38Abnormality of glycolipid metabolism (HP:0010969)3.10308388
39Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.08188928
40T lymphocytopenia (HP:0005403)3.04860731
41Abnormal delayed hypersensitivity skin test (HP:0002963)3.04004557
42Stomatitis (HP:0010280)3.03679615
43Parakeratosis (HP:0001036)3.00181024
44Chest pain (HP:0100749)2.98017133
45Abnormality of T cell number (HP:0011839)2.96965185
46Premature loss of primary teeth (HP:0006323)2.94088906
47Autoimmune thrombocytopenia (HP:0001973)2.91219592
48Recurrent fungal infections (HP:0002841)2.90534593
49Myocardial infarction (HP:0001658)2.88836073
50Dysostosis multiplex (HP:0000943)2.86690655
51Disinhibition (HP:0000734)2.84466165
52Interstitial pulmonary disease (HP:0006530)2.84108015
53Prolonged bleeding time (HP:0003010)2.83172895
54Orchitis (HP:0100796)2.82657938
55Erythroderma (HP:0001019)2.81703397
56Ectropion (HP:0000656)2.76207328
57Hypergammaglobulinemia (HP:0010702)2.74081687
58Chronic mucocutaneous candidiasis (HP:0002728)2.73523272
59Recurrent cutaneous fungal infections (HP:0011370)2.73523272
60Cellulitis (HP:0100658)2.71229805
61Abnormality of nail color (HP:0100643)2.67251401
62Pulmonary embolism (HP:0002204)2.65492214
63Loss of speech (HP:0002371)2.64190689
64Mucopolysacchariduria (HP:0008155)2.59956036
65Urinary glycosaminoglycan excretion (HP:0003541)2.59956036
66Epistaxis (HP:0000421)2.58747034
67Prostate neoplasm (HP:0100787)2.53832275
68Palmoplantar hyperkeratosis (HP:0000972)2.51015143
69* Sepsis (HP:0100806)2.49055650
70Tetraparesis (HP:0002273)2.46064659
71Plantar hyperkeratosis (HP:0007556)2.43061308
72Abnormality of the pleura (HP:0002103)2.41547073
73Abnormality of the peritoneum (HP:0002585)2.40021315
74Hepatosplenomegaly (HP:0001433)2.36807803
75Glomerulonephritis (HP:0000099)2.34866364
76Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.34358357
77Palmar hyperkeratosis (HP:0010765)2.31381048
78Retrobulbar optic neuritis (HP:0100654)2.30944559
79Optic neuritis (HP:0100653)2.30944559
80Keratitis (HP:0000491)2.30502013
81Vertigo (HP:0002321)2.28671168
82Abnormality of polysaccharide metabolism (HP:0011012)2.27425720
83Abnormality of glycosaminoglycan metabolism (HP:0004371)2.27425720
84Abnormality of mucopolysaccharide metabolism (HP:0011020)2.27425720
85Abnormality of the endocardium (HP:0004306)2.26977017
86Hypohidrosis (HP:0000966)2.25171940
87Elevated erythrocyte sedimentation rate (HP:0003565)2.23143931
88Abnormality of T cells (HP:0002843)2.20073868
89* Pruritus (HP:0000989)2.17188809
90Polyneuropathy (HP:0001271)2.15698313
91Hypotrichosis (HP:0001006)2.15056604
92Corneal erosion (HP:0200020)2.14916708
93Skin ulcer (HP:0200042)2.11949878
94Osteomyelitis (HP:0002754)2.11565818
95Malignant hyperthermia (HP:0002047)2.09558632
96Granulocytopenia (HP:0001913)2.09528329
97Subacute progressive viral hepatitis (HP:0006572)2.07010013
98Glomerulopathy (HP:0100820)2.06493188
99Inflammation of the large intestine (HP:0002037)2.06369880
100Segmental peripheral demyelination/remyelination (HP:0003481)2.05653854
101Recurrent viral infections (HP:0004429)2.05174686
102Basal ganglia calcification (HP:0002135)2.04570456
103Eosinophilia (HP:0001880)2.03671348
104Vasculitis (HP:0002633)2.03626061
105Autoimmune hemolytic anemia (HP:0001890)1.98733253
106Petechiae (HP:0000967)1.96039841
107Anorexia (HP:0002039)1.93990905
108Slow saccadic eye movements (HP:0000514)1.92977476
109Amaurosis fugax (HP:0100576)1.92160202
110Acne (HP:0001061)1.90910674
111Gingival bleeding (HP:0000225)1.90866020
112Type I diabetes mellitus (HP:0100651)1.90659096
113Gastrointestinal inflammation (HP:0004386)1.90141701
114Arterial thrombosis (HP:0004420)1.88896685
115Vertebral compression fractures (HP:0002953)1.88286313
116Thrombophlebitis (HP:0004418)1.87748201
117Hypercholesterolemia (HP:0003124)1.87219221
118Increased IgM level (HP:0003496)1.85948700
119Nephritis (HP:0000123)1.85250527
120Abnormal platelet volume (HP:0011876)1.82972857
121Meningitis (HP:0001287)1.82633549
122Viral hepatitis (HP:0006562)1.82362804
123Neoplasm of the tracheobronchial system (HP:0100552)1.82297624
124Lip pit (HP:0100267)1.81995998
125Pulmonary infiltrates (HP:0002113)1.81330234
126Hyporeflexia of lower limbs (HP:0002600)1.80932812
127Acute hepatic failure (HP:0006554)1.79852579
128Diminished motivation (HP:0000745)1.79634280
129Hematochezia (HP:0002573)1.78467413
130Fatigue (HP:0012378)1.78463170
131Abnormality of the pericardium (HP:0001697)1.78340528
132J-shaped sella turcica (HP:0002680)1.78183691
133Increased CSF protein (HP:0002922)1.78075691
134Skin rash (HP:0000988)1.77984772
135Peripheral demyelination (HP:0011096)1.77712231
136Abnormality of the lumbar spine (HP:0100712)1.77544465
137Osteolytic defects of the phalanges of the hand (HP:0009771)1.76812892
138Osteolytic defects of the hand bones (HP:0009699)1.76812892
139Anhidrosis (HP:0000970)1.76352764
140Increased serum ferritin (HP:0003281)1.74995276
141Leukocytosis (HP:0001974)1.74371522
142Apathy (HP:0000741)1.73213947
143Esophageal varix (HP:0002040)1.72785135
144Abnormality of T cell physiology (HP:0011840)1.71963633
145Nausea (HP:0002018)1.71359462
146Colitis (HP:0002583)1.70952655
147Abnormality of complement system (HP:0005339)1.70445589
148Cheilitis (HP:0100825)1.69802351

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.90648237
2PBK4.44103074
3RIPK44.38489542
4BLK3.88294903
5TBK13.31179583
6IRAK43.13413016
7MAP3K142.99338969
8ERN12.69993846
9NEK92.43909740
10IRAK12.26329782
11IRAK22.20082942
12NME21.89599868
13TYK21.83792324
14IKBKE1.80809577
15IRAK31.80544393
16BMX1.80346051
17RIPK11.75864129
18PRPF4B1.74783704
19GRK61.71418659
20TAOK31.68948257
21ERBB41.61748433
22MST41.60508197
23KIT1.59580138
24IKBKB1.59064484
25FGR1.50638311
26MARK31.47876083
27TAOK11.47696680
28MET1.42204270
29SYK1.37425663
30PIK3CG1.34982546
31MAP4K11.32042607
32KSR21.28802043
33ABL21.19225405
34JAK31.18161908
35TNK21.17523786
36ERBB31.17252228
37MAP3K131.13669429
38BMPR21.12093079
39STK41.07984627
40PKN21.06012917
41PIM21.04711181
42DYRK1B1.04671912
43ZAP701.04381446
44MAP3K111.03310715
45TRPM71.02687712
46JAK11.01518834
47MAP3K91.00873073
48STK101.00512368
49FGFR11.00246108
50LRRK20.98499822
51WNK10.98310788
52MAP3K20.92723319
53SIK30.92493167
54LYN0.89180855
55TTN0.87359749
56HCK0.86274284
57MARK20.85803193
58EPHB10.85714294
59JAK20.85259001
60LCK0.84795625
61EPHA30.82896161
62CSK0.82747204
63TRIB30.82224921
64TAOK20.80914338
65PTK60.78401776
66MATK0.78353643
67TEC0.78285354
68EGFR0.77691456
69RPS6KA40.77529658
70TESK10.77445318
71BMPR1B0.77265716
72RAF10.76708443
73MAP2K40.75594556
74TGFBR20.75579101
75SGK30.74350171
76KSR10.74269133
77SGK20.73509107
78SCYL20.72345033
79PRKCH0.71014058
80PRKCD0.69502583
81STK240.68478378
82ABL10.68261509
83CHUK0.67535013
84CDK60.66492001
85MOS0.63717630
86MAPKAPK30.62539949
87PDPK10.62147384
88MAPK70.60940246
89BTK0.60512265
90ARAF0.60472950
91DAPK20.56827759
92PDGFRB0.56056330
93MAP2K30.56050850
94NLK0.54226627
95MAPK120.52697579
96PRKCQ0.51807155
97MAP2K10.51489355
98MAP3K10.50943344
99DDR20.49272200
100CDC42BPA0.48727373
101FES0.48007522
102CAMKK20.45003440
103DYRK30.44584542
104CAMKK10.44391569
105STK110.43086610
106FYN0.42787128
107GSK3A0.41068354
108CSF1R0.40429778
109PDK10.40315038
110PDGFRA0.40153974
111PTK2B0.39923344
112MAPKAPK20.39712726
113PIM10.39659971
114PRKD20.39409509
115RET0.38792387
116MAP3K70.38520646
117MAP3K50.38283536
118ITK0.38154576
119SGK2230.37900502
120SGK4940.37900502
121TXK0.37566423
122MAP2K60.37470108
123STK30.37237193
124CDK190.35714013
125MAP3K30.33784694
126FGFR30.33574754
127ACVR1B0.33553864
128GRK70.32721424
129FGFR40.32197809
130RPS6KC10.31285317
131RPS6KL10.31285317
132MAP3K60.29855905
133HIPK20.29282770
134CAMK40.29191388
135NTRK10.29154725
136SRC0.28100601
137PRKCZ0.27692793
138EPHB20.27524347
139GRK50.27020605
140YES10.26834720
141RPS6KA60.26663492
142ERBB20.24430600

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.34396898
2Staphylococcus aureus infection_Homo sapiens_hsa051503.33761567
3Lysosome_Homo sapiens_hsa041422.89109068
4Legionellosis_Homo sapiens_hsa051342.76479309
5Tuberculosis_Homo sapiens_hsa051522.70073357
6Rheumatoid arthritis_Homo sapiens_hsa053232.58884240
7Phagosome_Homo sapiens_hsa041452.53064367
8Pertussis_Homo sapiens_hsa051332.40233635
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.34391529
10Osteoclast differentiation_Homo sapiens_hsa043802.24275408
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.20234548
12Malaria_Homo sapiens_hsa051442.13684017
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.09648795
14NF-kappa B signaling pathway_Homo sapiens_hsa040642.03617534
15Sphingolipid metabolism_Homo sapiens_hsa006001.87334201
16Collecting duct acid secretion_Homo sapiens_hsa049661.85296990
17Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.78293612
18Salmonella infection_Homo sapiens_hsa051321.78104271
19Other glycan degradation_Homo sapiens_hsa005111.74019861
20Graft-versus-host disease_Homo sapiens_hsa053321.66605618
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.65270558
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56128009
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.55535505
24TNF signaling pathway_Homo sapiens_hsa046681.54947733
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45934954
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.41150423
27Complement and coagulation cascades_Homo sapiens_hsa046101.37949455
28Antigen processing and presentation_Homo sapiens_hsa046121.36224047
29B cell receptor signaling pathway_Homo sapiens_hsa046621.33013716
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32719820
31Chemokine signaling pathway_Homo sapiens_hsa040621.32344725
32Histidine metabolism_Homo sapiens_hsa003401.28108880
33Measles_Homo sapiens_hsa051621.27418041
34Autoimmune thyroid disease_Homo sapiens_hsa053201.26548572
35African trypanosomiasis_Homo sapiens_hsa051431.24910875
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24224949
37Amoebiasis_Homo sapiens_hsa051461.22512441
38Apoptosis_Homo sapiens_hsa042101.19307295
39Toxoplasmosis_Homo sapiens_hsa051451.18899429
40Influenza A_Homo sapiens_hsa051641.17217473
41Non-small cell lung cancer_Homo sapiens_hsa052231.16054459
42Hematopoietic cell lineage_Homo sapiens_hsa046401.15285377
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.14665381
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07936070
45Vibrio cholerae infection_Homo sapiens_hsa051100.99523800
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98073852
47Sphingolipid signaling pathway_Homo sapiens_hsa040710.94458007
48Asthma_Homo sapiens_hsa053100.94131439
49Steroid biosynthesis_Homo sapiens_hsa001000.89427708
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88817579
51Arachidonic acid metabolism_Homo sapiens_hsa005900.87916948
52Hepatitis C_Homo sapiens_hsa051600.87139472
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86716385
54ABC transporters_Homo sapiens_hsa020100.85968647
55Shigellosis_Homo sapiens_hsa051310.85692739
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85655960
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84415761
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80487929
59Type I diabetes mellitus_Homo sapiens_hsa049400.78819124
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78333320
61Prion diseases_Homo sapiens_hsa050200.77356800
62FoxO signaling pathway_Homo sapiens_hsa040680.76646264
63GnRH signaling pathway_Homo sapiens_hsa049120.76362762
64Linoleic acid metabolism_Homo sapiens_hsa005910.76142211
65VEGF signaling pathway_Homo sapiens_hsa043700.72265469
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72218577
67Allograft rejection_Homo sapiens_hsa053300.70989886
68Notch signaling pathway_Homo sapiens_hsa043300.70247408
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.69655860
70Endocytosis_Homo sapiens_hsa041440.67509067
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.66047366
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.63717391
73Endometrial cancer_Homo sapiens_hsa052130.63379071
74Fatty acid elongation_Homo sapiens_hsa000620.62906999
75Platelet activation_Homo sapiens_hsa046110.62860179
76Choline metabolism in cancer_Homo sapiens_hsa052310.61235341
77Synaptic vesicle cycle_Homo sapiens_hsa047210.59992237
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58528008
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57893027
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57344305
81Type II diabetes mellitus_Homo sapiens_hsa049300.57092939
82Proteoglycans in cancer_Homo sapiens_hsa052050.56906092
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56664927
84MAPK signaling pathway_Homo sapiens_hsa040100.56286136
85Herpes simplex infection_Homo sapiens_hsa051680.56189926
86Acute myeloid leukemia_Homo sapiens_hsa052210.54318427
87mTOR signaling pathway_Homo sapiens_hsa041500.53861885
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53822529
89Hepatitis B_Homo sapiens_hsa051610.52452676
90Primary immunodeficiency_Homo sapiens_hsa053400.52155716
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50974151
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50907887
93Inositol phosphate metabolism_Homo sapiens_hsa005620.49905512
94Viral carcinogenesis_Homo sapiens_hsa052030.48637823
95Arginine biosynthesis_Homo sapiens_hsa002200.48441945
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47912848
97Prostate cancer_Homo sapiens_hsa052150.47896891
98Caffeine metabolism_Homo sapiens_hsa002320.46633465
99Bladder cancer_Homo sapiens_hsa052190.45826583
100Epstein-Barr virus infection_Homo sapiens_hsa051690.43703601
101Mineral absorption_Homo sapiens_hsa049780.43350414
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42923314
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42714720
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42051001
105Glioma_Homo sapiens_hsa052140.41293915
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41105548
107T cell receptor signaling pathway_Homo sapiens_hsa046600.39312785
108Rap1 signaling pathway_Homo sapiens_hsa040150.39295857
109Colorectal cancer_Homo sapiens_hsa052100.38491196
110Insulin resistance_Homo sapiens_hsa049310.37449987
111Prolactin signaling pathway_Homo sapiens_hsa049170.36699248
112Viral myocarditis_Homo sapiens_hsa054160.36524948
113Estrogen signaling pathway_Homo sapiens_hsa049150.35937766
114Renin-angiotensin system_Homo sapiens_hsa046140.35411121
115PPAR signaling pathway_Homo sapiens_hsa033200.34245322
116HIF-1 signaling pathway_Homo sapiens_hsa040660.33681469
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.33020565
118Chronic myeloid leukemia_Homo sapiens_hsa052200.32700554
119Ether lipid metabolism_Homo sapiens_hsa005650.31608794
120Fatty acid biosynthesis_Homo sapiens_hsa000610.31375702
121Pancreatic cancer_Homo sapiens_hsa052120.29996762
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.29498654
123Renal cell carcinoma_Homo sapiens_hsa052110.29406028
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29302123
125ErbB signaling pathway_Homo sapiens_hsa040120.29228173
126Dorso-ventral axis formation_Homo sapiens_hsa043200.27663827

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